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CHRFAM7A Gene

protein-coding   GIFtS: 55
GCID: GC15M030653

CHRNA7 (Cholinergic Receptor, Nicotinic, Alpha 7, Exons...

  See CHRFAM7A-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CHRNA7 (Cholinergic Receptor, Nicotinic, Alpha 7, Exons 5-10) And FAM7A
(Family With Sequence Similarity 7A, Exons A-E) Fusion1 2
     Alpha 7 Neuronal Nicotinic Acetylcholine Receptor-FAM7A Hybrid2
CHRNA7-DR12 3     Alpha-7 Nicotinic Cholinergic Receptor Subunit2
D-102 3     CHRNA7 (Cholinergic Receptor, Nicotinic, Alpha Polypeptide 7, Exons 5-10)
And FAM7A (Family With Sequence Similarity 7A, Exons A-E) Fusion2
CHRNA72     CHRNA7-FAM7A Fusion Protein2

External Ids:    HGNC: 157811   Entrez Gene: 898322   Ensembl: ENSG000001666647   OMIM: 6097565   UniProtKB: Q494W83   

Export aliases for CHRFAM7A gene to outside databases

Previous GC identifers: GC15M025924 GC15M023461 GC15M028233 GC15M028369 GC15M028440


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHRFAM7A Gene:
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that
mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a
region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a
novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two
variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading
frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain
but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription
of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading
frames has not been confirmed. (provided by RefSeq, Jul 2008)

GeneCards Summary for CHRFAM7A Gene:
CHRFAM7A (CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion) is a protein-coding gene. Diseases associated with CHRFAM7A include autosomal dominant nocturnal frontal lobe epilepsy, and frontal lobe epilepsy. GO annotations related to this gene include extracellular ligand-gated ion channel activity. An important paralog of this gene is HTR3E.

summary for CHRFAM7A Gene:
Alpha7 is a subunit of the neuronal nicotinic receptor that can combine to form homomeric receptors. In
avian tissue alpha7alpha8 heteromers also occur and an association between alpha7 and beta2 subunits has
been suggested in the mammalian brain. The alpha7 nAChR is particularly prominent in the hippocampus, where
it is found on GABAergic interneurons of stratum oriens and stratum radiatum, and on pyramidal neurones.
Presynaptic alpha7 nAChRs are present on glutamate terminals and facilitate transmitter release in various
brain regions, including the hippocampus, cortex and ventral tegmental area. Nicotine acting at alpha7
nAChRs can enhance hippocampal LTP, and alpha7 nAChRs are associated with attentional processes and working
memory. As a consequence, alpha7 nAChRs are a therapeutic target for treating cognitive impairment, notably
in Alzheimer's disease and schizophrenia, and this has prompted the generation of alpha7 nAChR-selective
ligands. The human gene encoding the nicotinic alpha7 receptor subunit has been localized to chromosome 15
(15q13.3).

Gene Wiki entry for CHRFAM7A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NT_187660.1  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRFAM7A gene promoter:
         E2F-4   E2F-3a   E2F-5   Pbx1a   p53   E2F-2   E2F   E2F-1   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRFAM7A promoter sequence
   Search Chromatin IP Primers for CHRFAM7A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRFAM7A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.1   Ensembl cytogenetic band:  15q13.2   HGNC cytogenetic band: 15q13.2

CHRFAM7A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRFAM7A gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M030653:  view genomic region     (about GC identifiers)

Start:
30,653,443 bp from pter      End:
30,686,052 bp from pter
Size:
32,610 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRFM7_HUMAN, Q494W8 (See protein sequence)
Recommended Name: CHRNA7-FAM7A fusion protein  
Size: 412 amino acids; 46218 Da
Caution: This protein is encoded by a hybrid gene consisting of a duplication of exons 5 through 10 of the CHRNA7
gene fused 3-prime to a copy of the FAM7A gene (exons A through E). The CHRFAM7A gene is in the opposite
orientation to the CHRNA7 gene. It seems not to be represented on every human chromosome 15 and it is not clear
whether the transcript is actually translated
Secondary accessions: A8KAB9

Explore the universe of human proteins at neXtProt for CHRFAM7A: NX_Q494W8

Explore proteomics data for CHRFAM7A at MOPED


See CHRFAM7A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_647536.1  NP_683709.1  

ENSEMBL proteins: 
 ENSP00000299847   ENSP00000385389   ENSP00000455401   ENSP00000380927  

CHRFAM7A Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:
 IPR027361 Acetylcholine_rcpt_TM
 IPR018000 Neurotransmitter_ion_chnl_CS
 IPR006201 Neur_channel
 IPR006202 Neur_chan_lig-bd
 IPR006029 Neurotrans-gated_channel_TM

Graphical View of Domain Structure for InterPro Entry Q494W8

ProtoNet protein and cluster: Q494W8

UniProtKB/Swiss-Prot: CRFM7_HUMAN, Q494W8
Similarity: Belongs to the ligand-gated ion channel (TC 1.A.9) family


Find genes that share domains with CHRFAM7A           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005230extracellular ligand-gated ion channel activity IEA--
     
Find genes that share ontologies with CHRFAM7A           About GenesLikeMe


Animal Models:
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miRNA
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miRTarBase miRNAs that target CHRFAM7A:
hsa-mir-181a-5p (MIRT025040), hsa-mir-335-5p (MIRT017997)

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2 qRT-PCR Assays for microRNAs that regulate CHRFAM7A:
hsa-miR-2355-3p hsa-miR-3174
SwitchGear 3'UTR luciferase reporter plasmidCHRFAM7A 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat CHRFAM7A

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CRFM7_HUMAN, Q494W8: Membrane; Multi-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
extracellular1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with CHRFAM7A           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CHRFAM7A About    
See pathways by source

SuperPathContained pathways About
1Activation of Nicotinic Acetylcholine Receptors
Activation of Nicotinic Acetylcholine Receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors0.00
Acetylcholine Binding And Downstream Events0.00
Postsynaptic nicotinic acetylcholine receptors0.00
2Transmission across Chemical Synapses
Transmission across Chemical Synapses0.72
Neuronal System0.68
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell0.72
3SIDS Susceptibility Pathways
SIDS Susceptibility Pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CHRFAM7A
    eNOS Signaling
Intracellular Calcium Signaling

1 BioSystems Pathway for CHRFAM7A
    SIDS Susceptibility Pathways



    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHRFAM7A
Interactions:

    Search GeneGlobe Interaction Network for CHRFAM7A

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CHRFAM7A (ENSP000002998474) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
LYPD1ENSP000003806054STRING: ENSP00000380605
NCAM1ENSP000003184724STRING: ENSP00000318472
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport ----
GO:0006811ion transport ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for CHRFAM7A available from Tocris Bioscience    About this table
CompoundAction CAS #
NS 1738Positive allosteric modulator of alpha7 nAChR; active in vivo[501684-93-1]
alpha-Bungarotoxinalpha7 subtype-selective nAChR antagonist[11032-79-4]
Methyllycaconitine citratealpha7 neuronal nicotinic receptor antagonist[21019-30-7]
PNU 282987Selective alpha7 nAChR agonist[123464-89-1]
PNU 120596Positive allosteric modulator of alpha7 nAChR; active in vivo[501925-31-1]

4 DrugBank Compounds for CHRFAM7A    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
(2E)-1-[(6-chloropyridin-3-yl)methyl]-N-nitroimidazolidin-2-imine-- --target--10592235
(3-EXO)-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8,8-DIMETHYL-8-AZONIABICYCLO[3.2.1]OCTANE-- --target--10592235
EPIBATIDINE-- --target--10592235
{(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide-- --target--10592235



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CHRFAM7A gene (2 alternative transcripts): 
NM_139320.1  NM_148911.1  

Unigene Cluster for CHRFAM7A:

CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
Hs.510853  [show with all ESTs]
Unigene Representative Sequence: NM_139320
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000299847 ENST00000401522 ENST00000562729 ENST00000567722 ENST00000569278
ENST00000570098 ENST00000397827(uc001zdt.1 uc001zdu.1 uc010azn.2)

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2 qRT-PCR Assays for microRNAs that regulate CHRFAM7A:
hsa-miR-2355-3p hsa-miR-3174
SwitchGear 3'UTR luciferase reporter plasmidCHRFAM7A 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CHRFAM7A
Predesigned siRNA for gene silencing in human, mouse, rat CHRFAM7A
Clone
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OriGene clones in human, mouse for CHRFAM7A (see all 10)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 2): CHRFAM7A (NM_148911)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRFAM7A
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRFAM7A
Primer
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OriGene qPCR primer pairs and template standards for CHRFAM7A
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Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CHRFAM7A
  QuantiTect SYBR Green Assays in human, mouse, rat CHRFAM7A
  QuantiFast Probe-based Assays in human, mouse, rat CHRFAM7A

Additional mRNA sequence: 

AF029838.1 AF029839.1 AF036903.1 AF037646.1 AK292984.1 BC101345.1 BC101346.2 BC101347.2 
BC101348.2 

12 DOTS entries:

DT.100025592  DT.100778391  DT.100778392  DT.121031753  DT.121033464  DT.102842464  DT.91679005  DT.92059623 
DT.100778393  DT.121031746  DT.121033553  DT.97837952 

Selected AceView cDNA sequences (see all 71):

BC037571 BX090309 BX282644 BF507825 BM451308 BU149265 AA639641 CR605947 
CR594008 CR620753 CR608436 BI963064 NM_000746 BX422848 AI791902 AI208142 
AA301331 BU680930 AA897701 AV727668 AU253237 AI742004 AU253238 BG925223 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CHRFAM7A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CACTGGAGTT
CHRFAM7A Expression
About this image

CHRFAM7A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CHRFAM7A Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.510853

UniProtKB/Swiss-Prot: CRFM7_HUMAN, Q494W8
Tissue specificity: Expressed in hippocampus

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CHRFAM7A gene from Selected species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
oppossum
(Monodelphis domestica)
Mammalia --
Uncharacterized protein
71(a)
1 → many
1(160970524-161179209)
chicken
(Gallus gallus)
Aves CHRNA76
Gallus gallus cholinergic receptor, nicotinic, alp...
72(a)
1 → many
10(6156717-6199170)
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
74(a)
1 → many
GL343486.1(221428-260641)
zebrafish
(Danio rerio)
Actinopterygii CABZ01069081.16
CABZ01088685.16
(see all 3)
Uncharacterized protein
(see all 3)
74(a)
68(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
25(595487-603447) ENSDARG00000086187
25(1110732-1116181) ENSDARG00000090271
fruit fly
(Drosophila melanogaster)
Insecta nAcRalpha-30D6
gfA6
(see all 3)
giant fibre A
(see all 3)
35(a)
34(a)
(see all 3)
many ↔ many
many ↔ many
(see all 3)
2L(9793424-9886250)
X(19222594-19242477)
worm
(Caenorhabditis elegans)
Secernentea acr-166
acr-196
(see all 10)
Protein ACR-16, isoform a
Protein ACR-19, isoform b (acr-19) mRNA, complete ...
(see all 10)
34(a)
31(a)
(see all 10)
many ↔ many
many ↔ many
(see all 10)
V(8561216-8564320) WBGene00000055
I(9031274-9036695) WBGene00000058


ENSEMBL Gene Tree for CHRFAM7A (if available)
TreeFam Gene Tree for CHRFAM7A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CHRFAM7A gene
HTR3E2  HTR3A2  CHRNA102  CHRNA92  HTR3B2  ZACN2  CHRNA72  HTR3C2  
HTR3D2  
13 SIMAP similar genes for CHRFAM7A using alignment to 3 protein entries:     CRFM7_HUMAN (see all proteins):
CHRNA7    CHRNA7-2    CHRNA6    CHRNA9    CHRNA2    CHRNB4
CHRNA4    CHRNA3    CHRNB2    CHRNA1    CHRNB1    CHRNA10
HTR3A

Find genes that share paralogs with CHRFAM7A           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CHRFAM7A (see all 78)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs3712112621,2
C--30668079(+) TGTGT-/GAGTGTT 2 -- int10--------
rs1996557221,2
C--30668090(+) GAGTC-/GTGTGGG 2 -- int10--------
rs1470593901,2
C--30668127(+) TGTGT-/GAGTGTT 2 -- int10--------
rs1927423311,2
C--30668138(+) GAGTCA/GTGTGG 2 -- int10--------
rs1462862931,2
C--30668185(+) GAGTC-/ATGTGGG 2 -- int10--------
rs719057201,2
C--30668186(+) AGTCG-/ATTGGGT 2 -- int10--------
rs1174490551,2
C--30668186(+) GAGTCA/GTGGGT 2 -- int10--------
rs1503284731,2
C--30668188(+) GTCGT-/GGGGTG 2 -- int10--------
rs784991251,2
C--30668328(+) GTGTG-/GT/TG 
        
AGGTG
2 -- int10--------
rs775711011,2
C--30668401(+) CTGTG-/TG    
   
/TGTG
AGTGG
2 -- int10--------

HapMap Linkage Disequilibrium report for CHRFAM7A (30653443 - 30686052 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CHRFAM7A (see all 32):    About this table    
Variant IDTypeSubtypePubMed ID
esv2749523CNV Deletion23290073
esv2421738CNV Duplication20811451
nsv903791CNV Loss21882294
nsv428300CNV Loss18775914
dgv2293n71CNV Loss21882294
esv2751526CNV Loss17911159
nsv903799CNV Loss21882294
nsv469586CNV Loss16826518
dgv2296n71CNV Loss21882294
dgv2297n71CNV Loss21882294

Human Gene Mutation Database (HGMD): CHRFAM7A
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609756    OMIM disorders: --

3 diseases for CHRFAM7A:    
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autosomal dominant nocturnal frontal lobe epilepsy    frontal lobe epilepsy    schizophrenia

1 disease from the University of Copenhagen DISEASES database for CHRFAM7A:
Schizophrenia

Find genes that share disorders with CHRFAM7A           About GenesLikeMe

Genetic Association Database (GAD): CHRFAM7A
Human Genome Epidemiology (HuGE) Navigator: CHRFAM7A (8 documents)

Export disorders for CHRFAM7A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CHRFAM7A gene, integrated from 10 sources (see all 26):
(articles sorted by number of sources associating them with CHRFAM7A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia. (PubMed id 19631623)1, 4, 9 Sinkus M.L....Leonard S. (Brain Res. 2009)
  2. CHRFAM7A copy number and 2-bp deletion polymorphisms and antisaccade performance. (PubMed id 19149910)1, 4, 9 Petrovsky N....Ettinger U. (Int. J. Neuropsychopharmacol. 2009)
  3. Association study of CHRFAM7A copy number and 2 bp deletion polymorphisms with schizophrenia and bipolar affective disorder. (PubMed id 16823804)1, 4, 9 Flomen R.H....Makoff A.J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2006)
  4. Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores. (PubMed id 19462340)1, 4, 9 Manchia M....Kennedy J.L. (World J. Biol. Psychiatry 2010)
  5. Association between a genetic variant of the alpha-7 nicotinic acetylcholine receptor subunit and four types of dementia. (PubMed id 19641318)1, 4 FehAcr A....Janka Z. (Dement Geriatr Cogn Disord 2009)
  6. Episodic memory performance predicted by the 2bp deletion in exon 6 of the &quot;alpha 7-like&quot; nicotinic receptor subunit gene. (PubMed id 17012698)1, 4 Dempster E.L....Collier D.A. (Am J Psychiatry 2006)
  7. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (Nature 2006)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  9. A 3-Mb map of a large segmental duplication overlapping the alpha7- nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14. (PubMed id 11829490)1, 3 Riley B.... Makoff A. (Genomics 2002)
  10. Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). (PubMed id 9782083)1, 2 Gault J.... Leonard S. (Genomics 1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 89832 HGNC: 15781 AceView: CHRNA7 Ensembl:ENSG00000166664 euGenes: HUgn89832
ECgene: CHRFAM7A H-InvDB: CHRFAM7A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CHRFAM7A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CHRFAM7A gene:
Search GeneIP for patents involving CHRFAM7A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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