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Aliases for CHRDL2 Gene

Aliases for CHRDL2 Gene

  • Chordin-Like 2 2 3 5
  • Breast Tumor Novel Factor 1 3 4
  • Chordin-Related Protein 2 3 4
  • BNF1 3 4
  • CHL2 3 4
  • BNF-1 4

External Ids for CHRDL2 Gene

Previous GeneCards Identifiers for CHRDL2 Gene

  • GC11M074133
  • GC11M074085
  • GC11M074407
  • GC11M070703

Summaries for CHRDL2 Gene

Entrez Gene Summary for CHRDL2 Gene

  • This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

GeneCards Summary for CHRDL2 Gene

CHRDL2 (Chordin-Like 2) is a Protein Coding gene. An important paralog of this gene is CHRD.

UniProtKB/Swiss-Prot for CHRDL2 Gene

  • May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRDL2 Gene

Genomics for CHRDL2 Gene

Regulatory Elements for CHRDL2 Gene

Enhancers for CHRDL2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHRDL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHRDL2 Gene

74,696,428 bp from pter
74,731,385 bp from pter
34,958 bases
Minus strand

Genomic View for CHRDL2 Gene

Genes around CHRDL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRDL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRDL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRDL2 Gene

Proteins for CHRDL2 Gene

  • Protein details for CHRDL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chordin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A5PKU9
    • Q6WN30
    • Q6WN31
    • Q6WN32
    • Q7Z5J3

    Protein attributes for CHRDL2 Gene

    429 amino acids
    Molecular mass:
    47495 Da
    Quaternary structure:
    • Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.

    Alternative splice isoforms for CHRDL2 Gene


neXtProt entry for CHRDL2 Gene

Proteomics data for CHRDL2 Gene at MOPED

Post-translational modifications for CHRDL2 Gene

  • Phosphorylated by FAM20C in the extracellular medium.
  • Glycosylation at Thr 100, Asn 114, and Ser 343
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CHRDL2 (Chordin-like 2/CHRDL2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CHRDL2

No data available for DME Specific Peptides for CHRDL2 Gene

Domains & Families for CHRDL2 Gene

Protein Domains for CHRDL2 Gene


Suggested Antigen Peptide Sequences for CHRDL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 VWFC domains.
  • Contains 3 VWFC domains.
genes like me logo Genes that share domains with CHRDL2: view

No data available for Gene Families for CHRDL2 Gene

Function for CHRDL2 Gene

Molecular function for CHRDL2 Gene

UniProtKB/Swiss-Prot Function:
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in breast tumors but also in lung and colon tumors.

Phenotypes for CHRDL2 Gene

genes like me logo Genes that share phenotypes with CHRDL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRDL2

miRNA for CHRDL2 Gene

miRTarBase miRNAs that target CHRDL2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHRDL2 Gene

Localization for CHRDL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRDL2 Gene

Isoform 1: Secreted.
Isoform 2: Secreted.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.

Subcellular locations from

Jensen Localization Image for CHRDL2 Gene COMPARTMENTS Subcellular localization image for CHRDL2 gene
Compartment Confidence
extracellular 5
mitochondrion 2
lysosome 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CHRDL2 Gene

Pathways & Interactions for CHRDL2 Gene

SuperPathways for CHRDL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
genes like me logo Genes that share ontologies with CHRDL2: view

No data available for Pathways by source and SIGNOR curated interactions for CHRDL2 Gene

Drugs & Compounds for CHRDL2 Gene

No Compound Related Data Available

Transcripts for CHRDL2 Gene

Unigene Clusters for CHRDL2 Gene

Chordin-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHRDL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for CHRDL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRDL2 Gene

mRNA expression in normal human tissues for CHRDL2 Gene

mRNA differential expression in normal tissues according to GTEx for CHRDL2 Gene

This gene is overexpressed in Uterus (x10.0), Colon - Sigmoid (x6.4), Cervix - Ectocervix (x5.9), and Stomach (x4.9).

Protein differential expression in normal tissues from HIPED for CHRDL2 Gene

This gene is overexpressed in Milk (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRDL2 Gene

SOURCE GeneReport for Unigene cluster for CHRDL2 Gene Hs.432379

mRNA Expression by UniProt/SwissProt for CHRDL2 Gene

Tissue specificity: Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.
genes like me logo Genes that share expression patterns with CHRDL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CHRDL2 Gene

Orthologs for CHRDL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRDL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHRDL2 35
  • 88.5 (n)
  • 89.04 (a)
  • 80 (a)
(Canis familiaris)
Mammalia CHRDL2 35
  • 83.54 (n)
  • 84.26 (a)
  • 81 (a)
(Mus musculus)
Mammalia Chrdl2 35
  • 80 (n)
  • 72.94 (a)
Chrdl2 16
Chrdl2 36
  • 62 (a)
(Pan troglodytes)
Mammalia CHRDL2 35
  • 93.93 (n)
  • 92.96 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Chrdl2 35
  • 79.67 (n)
  • 72.9 (a)
(Monodelphis domestica)
Mammalia CHRDL2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia CHRDL2 36
  • 54 (a)
(Gallus gallus)
Aves CHRDL2 35
  • 68.5 (n)
  • 65 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia CHRDL2 36
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733103 35
  • 72.99 (n)
  • 72.41 (a)
(Danio rerio)
Actinopterygii chrdl2 35
  • 55.35 (n)
  • 46.84 (a)
chrdl2 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta sog 36
  • 4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 2 (a)
Species with no ortholog for CHRDL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHRDL2 Gene

Gene Tree for CHRDL2 (if available)
Gene Tree for CHRDL2 (if available)

Paralogs for CHRDL2 Gene

Paralogs for CHRDL2 Gene

(4) SIMAP similar genes for CHRDL2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHRDL2: view

Variants for CHRDL2 Gene

Sequence variations from dbSNP and Humsavar for CHRDL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35903991 - 74,702,910(+) GGCCC(A/C/G/T)GTGCC reference, missense
rs948517 -- 74,705,841(+) AGGCT(C/T)CTGGG intron-variant
rs968305 -- 74,717,535(+) GTGTC(C/T)CCATT intron-variant
rs1281880 -- 74,711,717(+) cgcct(A/G)taatc intron-variant, upstream-variant-2KB
rs1433769 -- 74,712,468(+) GAGTC(A/G)GCATC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHRDL2 Gene

Variant ID Type Subtype PubMed ID
dgv397e1 CNV Complex 17122850
esv34979 CNV Gain 17911159
nsv825994 CNV Gain 20364138
nsv509431 CNV Insertion 20534489
esv2744778 CNV Deletion 23290073

Variation tolerance for CHRDL2 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CHRDL2 Gene

Disorders for CHRDL2 Gene

Relevant External Links for CHRDL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CHRDL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRDL2 Gene

Publications for CHRDL2 Gene

  1. BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues. (PMID: 12853144) Wu I. … Moses M.A. (Gene 2003) 2 3 4 67
  2. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. (PMID: 14660436) Nakayama N. … Zhang K. (Development 2004) 3 23
  3. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. (PMID: 15094188) Oren A. … Rotman G. (Gene 2004) 3 23
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3
  5. Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments. (PMID: 25575966) Chou C.H. … Wu C.C. (Osteoarthr. Cartil. 2015) 3

Products for CHRDL2 Gene

Sources for CHRDL2 Gene