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Aliases for CHRDL2 Gene

Aliases for CHRDL2 Gene

  • Chordin Like 2 2 3 5
  • Breast Tumor Novel Factor 1 3 4
  • Chordin-Related Protein 2 3 4
  • BNF1 3 4
  • CHL2 3 4
  • Chordin-Like Protein 2 3
  • BNF-1 4

External Ids for CHRDL2 Gene

Previous GeneCards Identifiers for CHRDL2 Gene

  • GC11M074133
  • GC11M074085
  • GC11M074407
  • GC11M070703

Summaries for CHRDL2 Gene

Entrez Gene Summary for CHRDL2 Gene

  • This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

GeneCards Summary for CHRDL2 Gene

CHRDL2 (Chordin Like 2) is a Protein Coding gene. An important paralog of this gene is CHRDL1.

UniProtKB/Swiss-Prot for CHRDL2 Gene

  • May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRDL2 Gene

Genomics for CHRDL2 Gene

Regulatory Elements for CHRDL2 Gene

Enhancers for CHRDL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G074671 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +58.2 58232 3.4 HDGF FOXA2 ATF1 ARNT SIN3A GATA2 ZNF143 FOS MBD2 MAFF CHRDL2 RPS12P22 KCNE3 RN7SKP297 GC11P074653
GH11G074685 1.1 dbSUPER 17 +43.9 43933 3.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 CHRDL2 KCNE3 RANP3 POLD3 ENSG00000254928 RN7SKP297 GC11M074700
GH11G074753 1.5 FANTOM5 Ensembl ENCODE 11.2 -23.5 -23544 2.8 TBP HDAC1 HDGF FOXA2 EGR1 ZNF143 FOS IKZF2 CREM ZNF263 CHRDL2 XRRA1 RNF169 POLD3 ENSG00000278879
GH11G074611 0.9 Ensembl ENCODE 15.9 +119.6 119585 0.8 CTCF MAFG BACH1 REST RAD21 ZNF592 ZNF316 SMC3 NFE2 EMSY CHRDL2 KCNE3 ENSG00000254928 POLD3 LOC105369386 GC11M074646
GH11G074682 1 Ensembl ENCODE dbSUPER 11.4 +47.8 47756 1.3 CTCF KDM1A HNF4A RAD21 ZBTB17 RANP3 CHRDL2 KCNE3 ENSG00000255440 RN7SKP297 GC11P074653
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHRDL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHRDL2 Gene

74,696,428 bp from pter
74,731,385 bp from pter
34,958 bases
Minus strand

Genomic View for CHRDL2 Gene

Genes around CHRDL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRDL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRDL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRDL2 Gene

Proteins for CHRDL2 Gene

  • Protein details for CHRDL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chordin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A5PKU9
    • Q6WN30
    • Q6WN31
    • Q6WN32
    • Q7Z5J3

    Protein attributes for CHRDL2 Gene

    429 amino acids
    Molecular mass:
    47495 Da
    Quaternary structure:
    • Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.

    Alternative splice isoforms for CHRDL2 Gene


neXtProt entry for CHRDL2 Gene

Post-translational modifications for CHRDL2 Gene

  • Phosphorylated by FAM20C in the extracellular medium.
  • Glycosylation at Thr100, posLast=114114, and posLast=343343
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CHRDL2 Gene

Domains & Families for CHRDL2 Gene

Protein Domains for CHRDL2 Gene


Suggested Antigen Peptide Sequences for CHRDL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHRDL2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CHRDL2 Gene

Function for CHRDL2 Gene

Molecular function for CHRDL2 Gene

UniProtKB/Swiss-Prot Function:
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in breast tumors but also in lung and colon tumors.
genes like me logo Genes that share phenotypes with CHRDL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHRDL2

CRISPR Products

miRNA for CHRDL2 Gene

miRTarBase miRNAs that target CHRDL2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHRDL2 Gene

Localization for CHRDL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRDL2 Gene

Isoform 1: Secreted.
Isoform 2: Secreted.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRDL2 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytoskeleton 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CHRDL2: view

Pathways & Interactions for CHRDL2 Gene

SuperPathways for CHRDL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0051216 cartilage development IEA --
genes like me logo Genes that share ontologies with CHRDL2: view

No data available for Pathways by source and SIGNOR curated interactions for CHRDL2 Gene

Drugs & Compounds for CHRDL2 Gene

No Compound Related Data Available

Transcripts for CHRDL2 Gene

Unigene Clusters for CHRDL2 Gene

Chordin-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRDL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for CHRDL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHRDL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHRDL2 Gene

mRNA differential expression in normal tissues according to GTEx for CHRDL2 Gene

This gene is overexpressed in Uterus (x10.0), Colon - Sigmoid (x6.4), Cervix - Ectocervix (x5.9), and Stomach (x4.9).

Protein differential expression in normal tissues from HIPED for CHRDL2 Gene

This gene is overexpressed in Milk (62.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHRDL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHRDL2 Gene:


SOURCE GeneReport for Unigene cluster for CHRDL2 Gene:


mRNA Expression by UniProt/SwissProt for CHRDL2 Gene:

Tissue specificity: Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.
genes like me logo Genes that share expression patterns with CHRDL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRDL2 Gene

Orthologs for CHRDL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRDL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHRDL2 34 35
  • 93.93 (n)
(Bos Taurus)
Mammalia CHRDL2 34 35
  • 88.5 (n)
(Canis familiaris)
Mammalia CHRDL2 34 35
  • 83.54 (n)
(Mus musculus)
Mammalia Chrdl2 34 16 35
  • 80 (n)
(Rattus norvegicus)
Mammalia Chrdl2 34
  • 79.67 (n)
(Monodelphis domestica)
Mammalia CHRDL2 35
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia CHRDL2 35
  • 54 (a)
(Gallus gallus)
Aves CHRDL2 34 35
  • 68.5 (n)
(Anolis carolinensis)
Reptilia CHRDL2 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733103 34
  • 72.99 (n)
(Danio rerio)
Actinopterygii chrdl2 34 35
  • 55.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta sog 35
  • 4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 2 (a)
Species where no ortholog for CHRDL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHRDL2 Gene

Gene Tree for CHRDL2 (if available)
Gene Tree for CHRDL2 (if available)

Paralogs for CHRDL2 Gene

Paralogs for CHRDL2 Gene

(4) SIMAP similar genes for CHRDL2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHRDL2: view

Variants for CHRDL2 Gene

Sequence variations from dbSNP and Humsavar for CHRDL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000055375 -- 74,724,805(+) AGCTT(G/T)GCTTC intron-variant
rs1000086981 -- 74,706,070(+) AGGGG(A/G)GTACA intron-variant
rs1000120771 -- 74,725,177(+) TAGTA(C/G)AGATG intron-variant
rs1000193620 -- 74,715,520(+) ATTGC(C/T)TGAAC intron-variant
rs1000338215 -- 74,712,131(+) TTTTT(A/T)AAAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHRDL2 Gene

Variant ID Type Subtype PubMed ID
dgv209e214 CNV gain 21293372
esv2744778 CNV deletion 23290073
esv2759837 CNV gain 17122850
esv34979 CNV gain 17911159
esv3626846 CNV gain 21293372
nsv509431 CNV insertion 20534489
nsv825994 CNV gain 20364138

Variation tolerance for CHRDL2 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.96; 49.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRDL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRDL2 Gene

Disorders for CHRDL2 Gene

Relevant External Links for CHRDL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CHRDL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRDL2 Gene

Publications for CHRDL2 Gene

  1. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. (PMID: 14660436) Nakayama N. … Zhang K. (Development 2004) 3 4 22 64
  2. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. (PMID: 15094188) Oren A. … Rotman G. (Gene 2004) 3 4 22 64
  3. BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues. (PMID: 12853144) Wu I. … Moses M.A. (Gene 2003) 2 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 46 64

Products for CHRDL2 Gene

Sources for CHRDL2 Gene

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