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Aliases for CHRDL2 Gene

Aliases for CHRDL2 Gene

  • Chordin-Like 2 2 3
  • BNF1 3 4 6
  • CHL2 3 4 6
  • Breast Tumor Novel Factor 1 3 4
  • Chordin-Related Protein 2 3 4
  • Chordin-Like Protein 2 3
  • BNF-1 4

External Ids for CHRDL2 Gene

Previous GeneCards Identifiers for CHRDL2 Gene

  • GC11M074133
  • GC11M074085
  • GC11M074407
  • GC11M070703

Summaries for CHRDL2 Gene

Entrez Gene Summary for CHRDL2 Gene

  • This gene encodes a member of the chordin family of proteins. Chordin family members are secreted proteins that share a cysteine-rich pro-collagen repeat domain and associate with members of the transforming growth factor beta superfamily. In vitro assays demonstrate a direct interaction between the encoded protein and human activin A. This gene is expressed in many tissues including osteoblasts, where it is differentially expressed during differentiation. In addition, its expression is upregulated in human osteoarthritic joint cartilage, suggesting a role in adult cartilage regeneration. [provided by RefSeq, Jan 2015]

GeneCards Summary for CHRDL2 Gene

CHRDL2 (Chordin-Like 2) is a Protein Coding gene. An important paralog of this gene is CHRD.

UniProtKB/Swiss-Prot for CHRDL2 Gene

  • May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRDL2 Gene

Genomics for CHRDL2 Gene

Regulatory Elements for CHRDL2 Gene

Genomic Location for CHRDL2 Gene

Start:
74,696,429 bp from pter
End:
74,731,385 bp from pter
Size:
34,957 bases
Orientation:
Minus strand

Genomic View for CHRDL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHRDL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRDL2 Gene

Proteins for CHRDL2 Gene

  • Protein details for CHRDL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WN34-CRDL2_HUMAN
    Recommended name:
    Chordin-like protein 2
    Protein Accession:
    Q6WN34
    Secondary Accessions:
    • A5PKU9
    • Q6WN30
    • Q6WN31
    • Q6WN32
    • Q7Z5J3

    Protein attributes for CHRDL2 Gene

    Size:
    429 amino acids
    Molecular mass:
    47495 Da
    Quaternary structure:
    • Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.

    Alternative splice isoforms for CHRDL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHRDL2 Gene

Proteomics data for CHRDL2 Gene at MOPED

Post-translational modifications for CHRDL2 Gene

  • Phosphorylation sites are present in the extracellular medium. Isoform 2 is phosphorylated on Ser-402
  • Glycosylation at Thr100, Asn114, Thr342, Ser343, Ser345, and Ser347
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CHRDL2 Gene

Domains for CHRDL2 Gene

Protein Domains for CHRDL2 Gene

Suggested Antigen Peptide Sequences for CHRDL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6WN34

UniProtKB/Swiss-Prot:

CRDL2_HUMAN :
  • Q6WN34
Domain:
  • Contains 3 VWFC domains.
genes like me logo Genes that share domains with CHRDL2: view

No data available for Gene Families for CHRDL2 Gene

Function for CHRDL2 Gene

Molecular function for CHRDL2 Gene

UniProtKB/Swiss-Prot Function: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.
UniProtKB/Swiss-Prot Induction: Up-regulated in breast tumors but also in lung and colon tumors.

Gene Ontology (GO) - Molecular Function for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CHRDL2: view

Animal Model Products

CRISPR Products

miRNA for CHRDL2 Gene

miRTarBase miRNAs that target CHRDL2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHRDL2 Gene

Localization for CHRDL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRDL2 Gene

Isoform 1: Secreted.
Isoform 2: Secreted.
Isoform 3: Cytoplasm.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRDL2 Gene COMPARTMENTS Subcellular localization image for CHRDL2 gene
Compartment Confidence
mitochondrion 4
extracellular 3
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CHRDL2: view

Pathways for CHRDL2 Gene

SuperPathways for CHRDL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHRDL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0030154 cell differentiation IEA --
GO:0030514 negative regulation of BMP signaling pathway IEA --
GO:0051216 cartilage development IEA --
genes like me logo Genes that share ontologies with CHRDL2: view

No data available for Pathways by source for CHRDL2 Gene

Transcripts for CHRDL2 Gene

Unigene Clusters for CHRDL2 Gene

Chordin-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHRDL2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CHRDL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRDL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for CHRDL2 Gene

GeneLoc Exon Structure for
CHRDL2
ECgene alternative splicing isoforms for
CHRDL2

Expression for CHRDL2 Gene

mRNA expression in normal human tissues for CHRDL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHRDL2 Gene

This gene is overexpressed in Uterus (10.0), Colon - Sigmoid (6.4), Cervix - Ectocervix (5.9), and Stomach (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHRDL2 Gene

SOURCE GeneReport for Unigene cluster for CHRDL2 Gene Hs.432379

mRNA Expression by UniProt/SwissProt for CHRDL2 Gene

Q6WN34-CRDL2_HUMAN
Tissue specificity: Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.
genes like me logo Genes that share expressions with CHRDL2: view

In Situ Assay Products

Orthologs for CHRDL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRDL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRDL2 35
  • 93.93 (n)
  • 92.96 (a)
CHRDL2 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHRDL2 35
  • 88.5 (n)
  • 89.04 (a)
CHRDL2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHRDL2 35
  • 83.54 (n)
  • 84.26 (a)
CHRDL2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrdl2 35
  • 80 (n)
  • 72.94 (a)
Chrdl2 16
Chrdl2 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHRDL2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRDL2 36
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrdl2 35
  • 79.67 (n)
  • 72.9 (a)
chicken
(Gallus gallus)
Aves CHRDL2 35
  • 68.5 (n)
  • 65 (a)
CHRDL2 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRDL2 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733103 35
  • 72.99 (n)
  • 72.41 (a)
zebrafish
(Danio rerio)
Actinopterygii chrdl2 35
  • 55.35 (n)
  • 46.84 (a)
chrdl2 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sog 36
  • 4 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 2 (a)
OneToMany
Species with no ortholog for CHRDL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHRDL2 Gene

ENSEMBL:
Gene Tree for CHRDL2 (if available)
TreeFam:
Gene Tree for CHRDL2 (if available)

Paralogs for CHRDL2 Gene

Paralogs for CHRDL2 Gene

Selected SIMAP similar genes for CHRDL2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHRDL2: view

Variants for CHRDL2 Gene

Sequence variations from dbSNP and Humsavar for CHRDL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs474563 -- 74,717,113(+) acaaa(A/C)aaaaa intron-variant
rs948517 -- 74,705,841(+) AGGCT(C/T)CTGGG intron-variant
rs968305 -- 74,717,535(+) GTGTC(C/T)CCATT intron-variant
rs1145670 -- 74,700,130(-) caaag(G/T)cacac intron-variant
rs1281880 -- 74,711,717(+) cgcct(A/G)taatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHRDL2 Gene

Variant ID Type Subtype PubMed ID
dgv397e1 CNV Complex 17122850
esv34979 CNV Gain 17911159
nsv825994 CNV Gain 20364138
nsv509431 CNV Insertion 20534489
esv2744778 CNV Deletion 23290073

Relevant External Links for CHRDL2 Gene

HapMap Linkage Disequilibrium report
CHRDL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRDL2 Gene

Disorders for CHRDL2 Gene

Relevant External Links for CHRDL2

Genetic Association Database (GAD)
CHRDL2
Human Genome Epidemiology (HuGE) Navigator
CHRDL2
genes like me logo Genes that share disorders with CHRDL2: view

No data available for UniProtKB/Swiss-Prot for CHRDL2 Gene

Publications for CHRDL2 Gene

  1. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. (PMID: 14660436) Nakayama N. … Zhang K. (Development 2004) 3 4 23
  2. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. (PMID: 15094188) Oren A. … Rotman G. (Gene 2004) 3 4 23
  3. BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues. (PMID: 12853144) Wu I. … Moses M.A. (Gene 2003) 2 3 4
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for CHRDL2 Gene

Sources for CHRDL2 Gene

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