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CHRDL2 Gene

protein-coding   GIFtS: 54
GCID: GC11M074407

Chordin-Like 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chordin-Like 21 2     Chordin-Related Protein 22 3
BNF12 3 5     BNF-12 3
CHL22 3 5     FKSG372
Breast Tumor Novel Factor 12 3     Chordin-Like Protein 22

External Ids:    HGNC: 241681   Entrez Gene: 258842   Ensembl: ENSG000000549387   OMIM: 6131275   UniProtKB: Q6WN343   

Export aliases for CHRDL2 gene to outside databases

Previous GC identifers: GC11M074133 GC11M074085 GC11M070703


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CHRDL2 Gene:
CHRDL2 (chordin-like 2) is a protein-coding gene. An important paralog of this gene is CHRDL1.

UniProtKB/Swiss-Prot: CRDL2_HUMAN, Q6WN34
Function: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator
effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the
rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast
and osteoblast differentiation, and maturation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRDL2 gene promoter:
         Egr-3   AhR   Pax-2   FOXO3   Pax-2a   Egr-4   Roaz   FOXO3b   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRDL2 promoter sequence
   Search Chromatin IP Primers for CHRDL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRDL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.4

CHRDL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRDL2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M074407:  view genomic region     (about GC identifiers)

Start:
74,407,474 bp from pter      End:
74,442,430 bp from pter
Size:
34,957 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CRDL2_HUMAN, Q6WN34 (See protein sequence)
Recommended Name: Chordin-like protein 2 precursor  
Size: 429 amino acids; 47495 Da
Subunit: Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA
Caution: According to PubMed:14660436, interacts with BMP2, BMP4, BMP5, BMP6, BMP7 but not INHBA. According to
PubMed:15094188, interacts with INHBA but not BMP2, BMP4 and BMP6
Secondary accessions: A5PKU9 Q6WN30 Q6WN31 Q6WN32 Q7Z5J3
Alternative splicing: 5 isoforms:  Q6WN34-1   Q6WN34-2   Q6WN34-3   Q6WN34-4   Q6WN34-5   

Explore the universe of human proteins at neXtProt for CHRDL2: NX_Q6WN34

Explore proteomics data for CHRDL2 at MOPED

Post-translational modifications: 

  • Phosphorylation sites are present in the extracellular medium. Isoform 2 is phosphorylated on Ser-4021
  • Glycosylation2 at Thr100, Asn114, Thr342, Ser343, Ser345, Ser347
  • Modification sites at PhosphoSitePlus

  • See CHRDL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265402.1  NP_056239.3  

    ENSEMBL proteins: 
     ENSP00000432345   ENSP00000434257   ENSP00000365502   ENSP00000263671   ENSP00000365510  
     ENSP00000432055   ENSP00000434589   ENSP00000431380  

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    antibodies-online proteins for CHRDL2 (2 products) 

     
    antibodies-online peptides for CHRDL2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry Q6WN34

    ProtoNet protein and cluster: Q6WN34

    1 Blocks protein domain: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: CRDL2_HUMAN, Q6WN34
    Similarity: Contains 3 VWFC domains


    Find genes that share domains with CHRDL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRDL2_HUMAN, Q6WN34
    Function: May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator
    effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the
    rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast
    and osteoblast differentiation, and maturation
    Induction: Up-regulated in breast tumors but also in lung and colon tumors

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CHRDL2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Chrdl2 (no phenotypes)

    Find genes that share phenotypes with CHRDL2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chrdl2tm1Lex for CHRDL2

       genOway: Develop your customized and physiologically relevant rodent model for CHRDL2

    miRNA
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    miRTarBase miRNAs that target CHRDL2:
    hsa-mir-335-5p (MIRT017465)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRDL2_HUMAN, Q6WN34: Isoform 1: Secreted (Potential)
    CRDL2_HUMAN, Q6WN34: Isoform 2: Secreted (Potential)
    CRDL2_HUMAN, Q6WN34: Isoform 3: Cytoplasm (Potential)
    CRDL2_HUMAN, Q6WN34: Isoform 4: Cytoplasm (Potential)
    CRDL2_HUMAN, Q6WN34: Isoform 5: Cytoplasm (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    extracellular3
    lysosome1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0005739mitochondrion ----

    Find genes that share ontologies with CHRDL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHRDL2
    Interactions:

        Search GeneGlobe Interaction Network for CHRDL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CHRDL2 (Q6WN343 ENSP000002636714) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP4P126443, ENSP000002454514I2D: score=3 STRING: ENSP00000245451
    GDF5P430263, ENSP000003634894I2D: score=3 STRING: ENSP00000363489
    INHBAP084763, ENSP000002422084I2D: score=2 STRING: ENSP00000242208
    BMP2P126433, ENSP000003681044I2D: score=3 STRING: ENSP00000368104
    BMP5P220033, ENSP000003598664I2D: score=2 STRING: ENSP00000359866
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0030154cell differentiation IEA--
    GO:0051216cartilage development IEA--

    Find genes that share ontologies with CHRDL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHRDL2 (CRDL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHRDL2 gene (2 alternative transcripts): 
    NM_001278473.1  NM_015424.4  

    Unigene Cluster for CHRDL2:

    Chordin-like 2
    Hs.432379  [show with all ESTs]
    Unigene Representative Sequence: AK304519
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000529912 ENST00000525413 ENST00000376324(uc001ovg.3) ENST00000263671(uc001ovh.3)
    ENST00000376332(uc001ovi.3) ENST00000534159 ENST00000534276 ENST00000528471(uc001ovj.1)
    ENST00000528789(uc001ovk.1)
    miRNA
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    hsa-miR-891b hsa-miR-889 hsa-miR-374b hsa-miR-374a hsa-miR-410
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    Additional mRNA sequence: 

    AF332891.1 AK304519.1 AL110168.1 AY163868.1 AY279090.1 AY279091.1 AY279092.1 AY279093.1 
    AY279094.1 AY358522.1 BC142623.1 JN579714.1 

    5 DOTS entries:

    DT.308150  DT.87046367  DT.102822817  DT.95188584  DT.75180512 

    Selected AceView cDNA sequences (see all 29):

    BX091758 AI205645 AY279094 AL047873 AY279093 NM_015424 AY279091 AY279090 
    AI343625 BF437637 AL110168 BX480331 AY358522 AY279092 AY163868 AW083466 
    BF437134 CB047807 AF332891 AI739159 AA042913 CB047808 AA037778 AV661482 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHRDL2 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:        -                                                                           
    SP2:        -                                                     -                     
    SP3:                    -                                         -                     
    SP4:        -                                         -                                 
    SP5:                                -                                                   


    ECgene alternative splicing isoforms for CHRDL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRDL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGGAAGAC
    CHRDL2 Expression
    About this image


    CHRDL2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     NULL (Uncategorized)
             Cartilage-like cells
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CHRDL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRDL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.432379

    UniProtKB/Swiss-Prot: CRDL2_HUMAN, Q6WN34
    Tissue specificity: Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary.
    Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory
    epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as
    the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal
    cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone.
    In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of
    chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is
    detected in fetal spleen. Isoform 2 present in plasma

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHRDL2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrdl21 , 5 chordin-like 21, 5 80(n)1
    72.94(a)1
      7 (54.29 cM)5
    691211  NM_133709.31  NP_598470.31 
     1000064045 
    chicken
    (Gallus gallus)
    Aves CHRDL21 chordin-like 2 68.5(n)
    65(a)
      419054  XM_417245.4  XP_417245.4 
    lizard
    (Anolis carolinensis)
    Reptilia CHRDL26
    chordin-like 2
    48(a)
    1 ↔ 1
    GL343489.1(546476-564315)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017331031 chordin-like protein 2-like 72.99(n)
    72.41(a)
      101733103  XM_004920933.1  XP_004920990.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chrdl21 chordin-like 2 55.35(n)
    46.84(a)
      563085  NM_001130959.1  NP_001124431.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sog6
    short gastrulation
    4(a)
    1 → many
    X(15497396-15527467)


    ENSEMBL Gene Tree for CHRDL2 (if available)
    TreeFam Gene Tree for CHRDL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHRDL2 gene
    CHRDL12  CHRD2  
    4 SIMAP similar genes for CHRDL2 using alignment to 5 protein entries:     CRDL2_HUMAN (see all proteins):
    bnf1    FKSG37    DKFZp586N2124    CHRDL1

    Find genes that share paralogs with CHRDL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHRDL2 (see all 779)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1167743191,2
    C--70740582(+) CCACCA/GTCTCA 1 -- us2k10--------
    rs1877795301,2
    --74407184(+) ATTAAC/TGCCCT 1 -- int10--------
    rs45393521,2
    C,F,A,H--74407269(+) AAGCAG/AGAGGT 1 -- int121Minor allele frequency- A:0.35NS EA NA CSA WA 2342
    rs1409677111,2
    --74407301(+) GAGGAA/GGCTGG 1 -- int10--------
    rs1156920871,2
    C,F--74407584(+) CTGGCC/TGTGAC 2 S G mis12Minor allele frequency- T:0.00WA NA 4670
    rs1408313101,2
    F--74407585(+) TGGCCG/ATGACC 2 /H syn11Minor allele frequency- A:0.00NA 4552
    rs1919851581,2
    C--74407586(+) GGCCGC/TGACCT 2 H R mis10--------
    rs1843932911,2
    C--74407663(+) GAGGCA/GTATGT 1 -- int10--------
    rs38192421,2
    C,F,A,H--74407676(+) CTGCAC/TGTGCA 1 -- int127Minor allele frequency- T:0.50NS EA NA WA CSA 2710
    rs1874890051,2
    --74407689(+) ACAGAA/GGCAGC 1 -- int10--------

    HapMap Linkage Disequilibrium report for CHRDL2 (74407474 - 74442430 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CHRDL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744778CNV Deletion23290073
    nsv509431CNV Insertion20534489
    esv34979CNV Gain17911159
    nsv825994CNV Gain20364138
    dgv397e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613127    OMIM disorders: --


    Find genes that share disorders with CHRDL2           About GenesLikeMe

    Genetic Association Database (GAD): CHRDL2
    Human Genome Epidemiology (HuGE) Navigator: CHRDL2 (2 documents)

    Export disorders for CHRDL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHRDL2 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CHRDL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. BNF-1, a novel gene encoding a putative extracellular matrix protein, is overexpressed in tumor tissues. (PubMed id 12853144)1, 2, 3 Wu I. and Moses M.A. (Gene 2003)
    3. A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage. (PubMed id 14660436)1, 2, 9 Nakayama N.... Zhang K. (Development 2004)
    4. hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. (PubMed id 15094188)1, 2, 9 Oren A.... Rotman G. (Gene 2004)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    6. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    7. Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. (PubMed id 18780401)2 Picariello G.... Addeo F. (Proteomics 2008)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25884 HGNC: 24168 AceView: CHRDL2 Ensembl:ENSG00000054938 euGenes: HUgn25884
    ECgene: CHRDL2 H-InvDB: CHRDL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHRDL2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHRDL2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHRDL2 gene:
    Search GeneIP for patents involving CHRDL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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