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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHRDL1 Gene

protein-coding   GIFtS: 59
GCID: GC0XM109917

chordin-like 1
 Explore 14 diseases affiliated with
CHRDL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CHRDL1    

Aliases
for CHRDL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chordin-Like 11 2     Neuralin-13
NRLN11 2 3     Neurogenesin-13
CHL1 2     Ventroptin3
VOPT2 5     Neuralin-13
Chordin-Like Protein 12     Neurogenesin-13
DA141H5.11     Ventroptin3
Neuralin 12     

External Ids:    HGNC: 298611   Entrez Gene: 918512   Ensembl: ENSG000001019387   OMIM: 3003505   UniProtKB: Q9BU403   

Export aliases for CHRDL1 gene to outside databases

Previous GC identifers: GC0XM108682 GC0XM109724 GC0XM099536


Summaries
for CHRDL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CHRDL1:
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic
retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced
transcript variants encoding different isoforms have been described. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
Function: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the
fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of
neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral
axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in
regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior
segment eye development




Genomic Views
for CHRDL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHRDL1 gene promoter:
         AP-1   ATF-2   Sox9   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHRDL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHRDL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRDL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

CHRDL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRDL1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM109917:  view genomic region     (about GC identifiers)

Start:
 109,917,084 bp from pter      End:
 110,039,286 bp from pter
Size:
 122,203 bases      Orientation:
 minus strand

Proteins
for CHRDL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40 (See protein sequence)
Recommended Name: Chordin-like protein 1 precursor  
Size: 450 amino acids; 51168 Da
Subcellular location: Secreted (Potential)
Sequence caution: Sequence=AAH02909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAU25841.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAF85795.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B1AKD0 B4DMP3 D3DUY6 Q539E4 Q9Y3H7
Alternative splicing: 4 isoforms:  Q9BU40-1   Q9BU40-2   Q9BU40-3   Q9BU40-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHRDL1: NX_Q9BU40

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BU40

    • CHRDL1 Protein expression data from MOPED and PaxDb: --
    REFSEQ proteins (4 alternative transcripts): 
    NP_001137453.1  NP_001137454.1  NP_001137455.2  NP_660277.2  

    ENSEMBL proteins: 
     ENSP00000361115   ENSP00000378276   ENSP00000361112   ENSP00000418443   ENSP00000399739  
     ENSP00000389627   ENSP00000218054  
    Reactome Protein details: Q9BU40
    Human Recombinant Protein Products: 
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    Novus Biologicals CHRDL1 Lysates
    Sino Biological Recombinant Protein for CHRDL1
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    Uscn Proteins for CHRDL1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--


    CHRDL1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CHRDL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CHRDL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry Q9BU40

    ProtoNet protein and cluster: Q9BU40

    1 Blocks protein family: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
    Similarity: Contains 3 VWFC domains


    Function
    for CHRDL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
    Function: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the
    fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of
    neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral
    axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in
    regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior
    segment eye development
    Induction: By hypoxia in retinal pericytes

    miRNA
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    hsa-miR-596 hsa-miR-429 hsa-miR-330-5p hsa-miR-765 hsa-miR-624* hsa-miR-578 hsa-miR-650 hsa-miR-4267
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    2 GenomeRNAi human phenotypes for CHRDL1:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for CHRDL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by BMP
    		Signaling by BMP1.00
    		BMP receptor signaling0.31
    2Signaling by GPCR
    		Signal Transduction0.56

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for CHRDL1 
        BMP receptor signaling

    2        Reactome Pathways for CHRDL1
        Signal Transduction
    Signaling by BMP



    CHRDL1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHRDL1

    2 Interacting proteins for CHRDL1 (Q9BU402, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3MINT-8201851 I2D: score=1 
    BMP4P126443I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001654eye development IMP--
    GO:0001709cell fate determination ----
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--


    CHRDL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CHRDL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHRDL1
    Search CenterWatch for drugs/clinical trials and news about CHRDL1 / CRDL1 

    Transcripts
    for CHRDL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CHRDL1 gene (4 alternative transcripts): 
    NM_001143981.1  NM_001143982.1  NM_001143983.2  NM_145234.3  

    Unigene Cluster for CHRDL1:

    Chordin-like 1
    Hs.496587  [show with all ESTs]
    Unigene Representative Sequence: NM_001143981
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372045(uc004eov.3) ENST00000394797 ENST00000372042 ENST00000482160
    ENST00000444321 ENST00000434224(uc011mss.2) ENST00000218054(uc004eow.3 uc010nps.3 uc004eou.4)


    miRNA
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    8/50 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRDL1 (see all 50):
    hsa-miR-596 hsa-miR-429 hsa-miR-330-5p hsa-miR-765 hsa-miR-624* hsa-miR-578 hsa-miR-650 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmid: CHRDL1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209548.1 AK092245.1 AK293106.1 AK297563.1 AK312270.1 AY608914.1 BC002909.2 

    5 DOTS entries:

    DT.455245  DT.95216680  DT.91900469  DT.100719272  DT.91716810 

    24/116 AceView cDNA sequences (see all 116):

    AA724504 BQ898504 BC002909 AI123481 AA844567 AA724151 CF529723 BM991264 
    AI246227 CR623913 AI984312 AA149964 BI868201 AW468753 NM_145234 AA327755 
    AW271266 AW294402 AI337909 AI633535 AW027983 AI804767 CR604833 AW051660 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CHRDL1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                          -                                                                                 
    SP2:                          -                                                                                 
    SP3:                                                                          -                                 
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for CHRDL1

    Expression
    for CHRDL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHRDL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CHRDL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Neural EctodermNeural PlateSpinal Neural Plate CellsNeural Ectoderm
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    PlacentaChorioallantoic PlacentaExtraembryonic AngioblastsEndothelium
    AdiposeVisceral White AdiposeAdipose
    BoneMandibular ProcessBone
    BoneZeugopod Growth PlateBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    Genevestigator expression for CHRDL1

    SOURCE GeneReport for Unigene cluster: Hs.496587

    UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
    Tissue specificity: Expressed in the developing cornea and in the eye anterior segment in addition to the retina.
    Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in
    retinal pericytes

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    In Situ
    Assay Products:     
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    Orthologs
    for CHRDL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for CHRDL1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CHRDL11 chordin-like 1 76.47(n)
    81.19(a)    		   373985  NM_204171.1  NP_989502.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CHRDL16
    		 --
    		 73(a)
    		 1 ↔ 1
    		 GL343376.1(125072-147939)
    zebrafish
    (Danio rerio)    		 Actinopterygii chrdl26
    		 chordin-like 2
    		 35(a)
    		 1 → many
    		 21(20723685-20733029)


    ENSEMBL Gene Tree for CHRDL1 (if available)
    TreeFam Gene Tree for CHRDL1 (if available) 

    Paralogs
    for CHRDL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHRDL1 gene
    CHRD2  VWCE2  CRIM12  CHRDL22  
    3 SIMAP similar genes for CHRDL1 using alignment to 3 protein entries:     CRDL1_HUMAN (see all proteins):
    DKFZp586N2124    CHRDL2    FKSG37

    CHRDL1 for paralogs           About GeneDecksing



    Genomic Variants
    for CHRDL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1500 NCBI SNPs in CHRDL1 are shown (see all 1500)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1495119931,2
    		--109916598(+) AAAAAA/GTAATG 4 -- ds50010--------
    rs1855568271,2
    		--109916715(+) AGCCAC/TTTTCA 4 -- ds50010--------
    rs1895287961,2
    		--109916753(+) GTCATA/GAATGA 4 -- ds50010--------
    rs1439860271,2
    		--109916866(+) TTCCAC/TTTTAT 4 -- ds50010--------
    rs1808692311,2
    		--109916893(+) AAATAC/TGGCTG 4 -- ds50010--------
    rs1862491231,2
    		--109916970(+) TGCTAC/TAGTAT 4 -- ds50010--------
    rs1920558791,2
    		--109917036(+) TCCAAA/GGTCAG 4 -- ds50010--------
    rs115541711,2
    		C--109917333(+) TTCTCT/CACTAA 4 -- ut31 ese32Minor allele frequency- C:0.00NA 4
    rs1836023841,2
    		--109917630(+) ATGGAA/GTCACT 4 -- ut310--------
    rs169860761,2
    		C,F,--109917649(+) TGGGAC/TGGAGG 4 -- ut31 ese33Minor allele frequency- T:0.01NA 142

    HapMap Linkage Disequilibrium report for CHRDL1 (109917084 - 110039286 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for CHRDL1
         5 CNVs: 1864 38762 68015 96892 83678
    Human Gene Mutation Database (HGMD): CHRDL1

    Locus Specific Mutation Databases (LSDB): CHRDL1

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    Disorders / Diseases
    for CHRDL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CHRDL1 for disorders           About GeneDecksing

    OMIM gene information: 300350    OMIM disorders: --

    UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
  • Defects in CHRDL1 are the cause of megalocornea type 1, X-linked (MGC1) [MIM:309300]. MGC1 is an eye disorder
    • in which the corneal diameter is bilaterally enlarged (greater than 13 mm) without an increase in intraocular
    pressure. It may also be referred to as anterior megalophthalmos, since the entire anterior segment is larger than
    normal. Features of megalocornea in addition to a deep anterior chamber include astigmatic refractive errors, atrophy
    of the iris stroma, miosis secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness,
    subluxation, or dislocation of the lens. Whereas most affected individuals exhibit normal ocular function,
    complications include cataract development and glaucoma following lenticular dislocation or subluxation

    14 diseases for CHRDL1:    About MalaCards
    diffuse large b-cell lymphoma    age related macular degeneration    hypoxia    b-cell lymphomas
    retinitis    non-hodgkin lymphoma    macular degeneration    corneal degeneration
    hodgkin's lymphoma    amblyopia    nephrotic syndrome    mediastinitis
    neuronitis    megalocornea

    1 disease from the University of Copenhagen DISEASES database for CHRDL1:
    Corneal degeneration

    6 Novoseek disease relationships for CHRDL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 85.7 18 17539776 (1), 15732141 (1), 19075188 (1), 12939740 (1) (see all 16)
    lymphoma b-cell 61.4 1 17938252 (1)
    lymphoma 47.7 7 16007868 (3), 12670918 (1), 18704935 (1), 16614247 (1)
    sclerosis 42.8 3 20093237 (1), 12933571 (1), 17876757 (1)
    tumors 11.5 1 19666866 (1)
    chromosomal aberrations 8.09 5 16787866 (2), 12939740 (1)


    Export disorders for CHRDL1 gene to outside databases

    Publications
    for CHRDL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHRDL1 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with CHRDL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate. (PubMed id 11118896)1, 3, 9 Coffinier C....De Robertis E.M. (2001)
    2. Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina. (PubMed id 11441185)1, 3, 9 Sakuta H....Noda M. (2001)
    3. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. (PubMed id 18587495)1, 2, 9 Kane R.... O'Brien C. (2008)
    4. X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development. (PubMed id 22284829)1, 2 Webb T.R.... Hardcastle A.J. (2012)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Effect of chordin-like 1 on MC3T3-E1 and human mesenc hymal stem cells. (PubMed id 20130390)1, 9 Fernandes H....de Boer J. (2010)
    9. Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury. (PubMed id 19357253)1, 9 Larman B.W....Oxburgh L. (2009)
    10. Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. (PubMed id 17881565)1, 9 Kosinski C....Chen X. (2007)

    External Searches for CHRDL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CHRDL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91851 HGNC: 29861 AceView: CHRDL1 Ensembl:ENSG00000101938 euGenes: HUgn91851
    ECgene: CHRDL1 H-InvDB: CHRDL1

    Other Databases showing CHRDL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CHRDL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHRDL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CHRDL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CHRDL1 gene:
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