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CHRDL1 Gene

protein-coding   GIFtS: 60
GCID: GC0XM109917

Chordin-Like 1

(Previous name: megalocornea 1 (X-linked))
(Previous symbol: MGC1)
  See CHRDL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chordin-Like 11 2     dA141H5.12
MGC11 2 5     Neuralin 12
Megalocornea 1 (X-Linked)1 2     neuralin-12
NRLN12 3     neurogenesin-12
VOPT2 5     ventroptin2
CHL2     Neuralin-13
MGCN2     Neurogenesin-13
Chordin-Like Protein 12     Ventroptin3

External Ids:    HGNC: 298611   Entrez Gene: 918512   Ensembl: ENSG000001019387   OMIM: 3003505   UniProtKB: Q9BU403   

Export aliases for CHRDL1 gene to outside databases

Previous GC identifers: GC0XM108682 GC0XM109724 GC0XM099536


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHRDL1 Gene:
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in
topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia.
Alternatively spliced transcript variants encoding different isoforms have been described. (provided by RefSeq,
Jan 2009)

GeneCards Summary for CHRDL1 Gene:
CHRDL1 (chordin-like 1) is a protein-coding gene. Diseases associated with CHRDL1 include megalocornea 1, x-linked, and corneal degeneration. An important paralog of this gene is CHRD.

UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
Function: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters
the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal
differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial
role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play
an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells.
Plays a role during anterior segment eye development




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHRDL1 gene promoter:
         AP-1   ATF-2   Sox9   STAT3   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHRDL1 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHRDL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq23   Ensembl cytogenetic band:  Xq23   HGNC cytogenetic band: Xq23

CHRDL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRDL1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM109917:  view genomic region     (about GC identifiers)

Start:
109,917,084 bp from pter      End:
110,039,286 bp from pter
Size:
122,203 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40 (See protein sequence)
Recommended Name: Chordin-like protein 1 precursor  
Size: 450 amino acids; 51168 Da
Sequence caution: Sequence=AAH02909.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAU25841.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAF85795.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B1AKD0 B4DMP3 D3DUY6 E9PGS5 Q539E4 Q9Y3H7
Alternative splicing: 6 isoforms:  Q9BU40-1   Q9BU40-2   Q9BU40-3   Q9BU40-4   Q9BU40-5   Q9BU40-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHRDL1: NX_Q9BU40

Explore proteomics data for CHRDL1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn112, Asn285

  • See CHRDL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001137453.1  NP_001137454.1  NP_001137455.2  NP_660277.2  

    ENSEMBL proteins: 
     ENSP00000361115   ENSP00000378276   ENSP00000361112   ENSP00000418443   ENSP00000399739  
     ENSP00000389627   ENSP00000218054  
    Reactome Protein details: Q9BU40

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry Q9BU40

    ProtoNet protein and cluster: Q9BU40

    1 Blocks protein domain: IPB001007 von Willebrand factor

    UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
    Similarity: Contains 3 VWFC domains


    Find genes that share domains with CHRDL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CRDL1_HUMAN, Q9BU40
    Function: Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters
    the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal
    differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial
    role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play
    an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells.
    Plays a role during anterior segment eye development
    Induction: By hypoxia in retinal pericytes

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CHRDL1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CHRDL1:
     Decreased POU5F1-GFP protein e  Increased gamma-H2AX phosphory 

    Animal Models:
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    hsa-mir-124-3p (MIRT022205)

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    hsa-miR-596 hsa-miR-429 hsa-miR-330-5p hsa-miR-765 hsa-miR-624* hsa-miR-578 hsa-miR-650 hsa-miR-4267
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CRDL1_HUMAN, Q9BU40: Secreted (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton1
    cytosol1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with CHRDL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHRDL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    Signaling by BMP0.35
    BMP receptor signaling0.31
    2Signaling by GPCR
    Signal Transduction0.58
    3TGF-beta Signaling Pathway (sino)
    TGF-beta Signaling Pathway


    Find genes that share SuperPaths with CHRDL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CHRDL1
        BMP receptor signaling

    1 Sino Biological Pathway for CHRDL1
        TGF-beta Signaling Pathway

    1 Reactome Pathway for CHRDL1
        Signaling by BMP


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHRDL1
    Interactions:

        Search GeneGlobe Interaction Network for CHRDL1

    2 Interacting proteins for CHRDL1 (Q9BU402, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARP2Q9UGN52, 3MINT-8201851 I2D: score=1 
    BMP4P126443I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001654eye development IMP--
    GO:0007399nervous system development IEA--
    GO:0030154cell differentiation IEA--
    GO:0030509BMP signaling pathway TAS--

    Find genes that share ontologies with CHRDL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CHRDL1 (CRDL1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHRDL1 gene (4 alternative transcripts): 
    NM_001143981.1  NM_001143982.1  NM_001143983.2  NM_145234.3  

    Unigene Cluster for CHRDL1:

    Chordin-like 1
    Hs.496587  [show with all ESTs]
    Unigene Representative Sequence: NM_001143981
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372045(uc004eov.3) ENST00000394797 ENST00000372042 ENST00000482160
    ENST00000444321 ENST00000434224(uc011mss.2) ENST00000218054(uc004eow.3 uc010nps.3 uc004eou.4)

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    hsa-miR-596 hsa-miR-429 hsa-miR-330-5p hsa-miR-765 hsa-miR-624* hsa-miR-578 hsa-miR-650 hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidCHRDL1 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat CHRDL1
      QuantiFast Probe-based Assays in human, mouse, rat CHRDL1

    Additional mRNA sequence: 

    AB209548.1 AK092245.1 AK293106.1 AK297563.1 AK312270.1 AY608914.1 BC002909.2 

    5 DOTS entries:

    DT.455245  DT.95216680  DT.91900469  DT.100719272  DT.91716810 

    Selected AceView cDNA sequences (see all 116):

    AI337909 AI984312 CR623913 Z42301 AW468753 AI810225 CA393800 AA844567 
    CR604833 AI633535 BM991264 AW051660 AA724151 BQ898504 AA854359 AW271266 
    BI868201 AA724504 AW027983 AI004265 BC002909 BP377491 AW294402 CF529723 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CHRDL1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b
    SP1:                          -                                                                                 
    SP2:                          -                                                                                 
    SP3:                                                                          -                                 
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for CHRDL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHRDL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHRDL1 Expression
    About this image


    CHRDL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Visceral White Adipocytes Visceral White Adipose
             Visceral White Adipose
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
     
     Neural Ectoderm (Nervous System)
             Spinal Neural Plate Cells Neural Plate
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CHRDL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHRDL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496587

    UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
    Tissue specificity: Expressed in the developing cornea and in the eye anterior segment in addition to the retina.
    Differentially expressed in the fetal brain. There is high expression in cerebellum and neocortex. Expressed in
    retinal pericytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHRDL1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrdl11 , 5 chordin-like 11, 5 89.76(n)1
    90.81(a)1
      X (64.24 cM)5
    834531  NM_001114385.11  NP_001107857.11 
     1432856745 
    chicken
    (Gallus gallus)
    Aves CHRDL11 chordin-like 1 76.4(n)
    80.97(a)
      373985  NM_204171.1  NP_989502.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHRDL16
    chordin-like 1
    73(a)
    1 ↔ 1
    GL343376.1(121578-152711)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia chrdl11 chordin-like 1 66.4(n)
    68.32(a)
      100144642  NM_001123417.2  NP_001116889.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sog6
    short gastrulation
    4(a)
    1 → many
    X(15497396-15527467)


    ENSEMBL Gene Tree for CHRDL1 (if available)
    TreeFam Gene Tree for CHRDL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHRDL1 gene
    CHRD2  CHRDL22  
    3 SIMAP similar genes for CHRDL1 using alignment to 2 protein entries:     CRDL1_HUMAN (see all proteins):
    DKFZp586N2124    CHRDL2    FKSG37

    Find genes that share paralogs with CHRDL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHRDL1 (see all 1741)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0681754
    Megalocornea 1, X-linked (MGC1)4--see VAR_0681752 C F mis40--------
    rs1495119931,2
    --109896696(+) AAAAAA/GTAATG 4 -- ds50010--------
    rs1855568271,2
    --109896813(+) AGCCAC/TTTTCA 4 -- ds50010--------
    rs1895287961,2
    --109896851(+) GTCATA/GAATGA 4 -- ds50010--------
    rs1439860271,2
    --109896964(+) TTCCAC/TTTTAT 4 -- ds50010--------
    rs1808692311,2
    --109896991(+) AAATAC/TGGCTG 4 -- ds50010--------
    rs1862491231,2
    --109897068(+) TGCTAC/TAGTAT 4 -- ds50010--------
    rs1920558791,2
    --109897134(+) TCCAAA/GGTCAG 4 -- ds50010--------
    rs115541711,2
    C--109897431(+) TTCTCT/CACTAA 4 -- ut31 ese32Minor allele frequency- C:0.00NA 4
    rs1836023841,2
    C--109897728(+) ATGGAA/GTCACT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for CHRDL1 (109917084 - 110039286 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CHRDL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666835CNV Deletion23128226
    esv2667764CNV Deletion23128226
    nsv507988CNV Insertion20534489
    esv1358058CNV Insertion17803354
    nsv515161CNV Loss21397061
    esv21564CNV Loss19812545
    nsv7037CNV Loss18451855
    nsv438151CNV Loss16468122
    nsv442813CNV CNV18776908

    Human Gene Mutation Database (HGMD): CHRDL1
    Locus Specific Mutation Databases (LSDB): CHRDL1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300350   
    OMIM disorders: 309300  
    UniProtKB/Swiss-Prot: CRDL1_HUMAN, Q9BU40
  • Megalocornea 1, X-linked (MGC1) [MIM:309300]: An eye disorder in which the corneal diameter is
    bilaterally enlarged (greater than 13 mm) without an increase in intraocular pressure. It may also be referred to
    as anterior megalophthalmos, since the entire anterior segment is larger than normal. Features of megalocornea in
    addition to a deep anterior chamber include astigmatic refractive errors, atrophy of the iris stroma, miosis
    secondary to decreased function of the dilator muscle, iridodonesis, and tremulousness, subluxation, or
    dislocation of the lens. Whereas most affected individuals exhibit normal ocular function, complications include
    cataract development and glaucoma following lenticular dislocation or subluxation. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 5 diseases for CHRDL1:    
    About MalaCards
    megalocornea 1, x-linked    corneal degeneration    lymphocyte-rich classical hodgkin lymphoma    hodgkin's lymphoma
    hypoxia

    1 disease from the University of Copenhagen DISEASES database for CHRDL1:
    Corneal degeneration

    Find genes that share disorders with CHRDL1           About GenesLikeMe

    6 Novoseek inferred disease relationships for CHRDL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hodgkin disease 85.7 18 17539776 (1), 15732141 (1), 19075188 (1), 12939740 (1) (see all 16)
    lymphoma b-cell 61.4 1 17938252 (1)
    lymphoma 47.7 7 16007868 (3), 12670918 (1), 18704935 (1), 16614247 (1)
    sclerosis 42.8 3 20093237 (1), 12933571 (1), 17876757 (1)
    tumors 11.5 1 19666866 (1)
    chromosomal aberrations 8.09 5 16787866 (2), 12939740 (1)

    Genetic Association Database (GAD): CHRDL1

    Export disorders for CHRDL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CHRDL1 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with CHRDL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. X-linked megalocornea caused by mutations in CHRDL1 identifies an essential role for ventroptin in anterior segment development. (PubMed id 22284829)1, 2, 3 Webb T.R.... Hardcastle A.J. (Am. J. Hum. Genet. 2012)
    2. Neuralin-1 is a novel Chordin-related molecule expressed in the mouse neural plate. (PubMed id 11118896)1, 3, 9 Coffinier C....De Robertis E.M. (Mech. Dev. 2001)
    3. Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina. (PubMed id 11441185)1, 3, 9 Sakuta H....Noda M. (Science 2001)
    4. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis. (PubMed id 18587495)1, 2, 9 Kane R.... O'Brien C. (Mol. Vis. 2008)
    5. A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease. (PubMed id 21378988)1, 4 (Nat. Genet. 2011)
    6. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Effect of chordin-like 1 on MC3T3-E1 and human mesenchymal stem cells. (PubMed id 20130390)1, 9 Fernandes H....de Boer J. (Cells Tissues Organs (Print) 2010)
    10. Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury. (PubMed id 19357253)1, 9 Larman B.W....Oxburgh L. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 91851 HGNC: 29861 AceView: CHRDL1 Ensembl:ENSG00000101938 euGenes: HUgn91851
    ECgene: CHRDL1 H-InvDB: CHRDL1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHRDL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CHRDL1 gene:
    Search GeneIP for patents involving CHRDL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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