Aliases for CHRDL1 Gene
External Ids for CHRDL1 Gene
Previous HGNC Symbols for CHRDL1 Gene
Previous GeneCards Identifiers for CHRDL1 Gene
This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
GeneCards Summary for CHRDL1 Gene
CHRDL1 (Chordin-Like 1) is a Protein Coding gene. Diseases associated with CHRDL1 include isolated congenital megalocornea and megalocornea 1, x-linked. Among its related pathways are Signaling by GPCR and TGF-beta Signaling Pathway (sino). An important paralog of this gene is CHRD.
UniProtKB/Swiss-Prot for CHRDL1 Gene
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development.