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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHRD Gene

protein-coding   GIFtS: 60
GCID: GC03P184097

Chordin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
chordin1 2

External Ids:    HGNC: 19491   Entrez Gene: 86462   Ensembl: ENSG000000905397   OMIM: 6034755   UniProtKB: Q9H2X03   

Export aliases for CHRD gene to outside databases

Previous GC identifers: GC03P180570 GC03P185091 GC03P185499 GC03P185419 GC03P185421 GC03P185580 GC03P181483


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHRD Gene:
This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing
TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also
have roles in organogenesis and during adulthood. Multiple transcript variants encoding distinct isoforms have
been identified for this gene. Other alternative splice variants have been described but their full length
sequence has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for CHRD Gene: 
CHRD (chordin) is a protein-coding gene. Diseases associated with CHRD include hepatoerythropoietic porphyria, and cornelia de lange syndrome, and among its related super-pathways are Signaling by BMP. GO annotations related to this gene include heparin binding and syndecan binding. An important paralog of this gene is CHRDL1.

UniProtKB/Swiss-Prot: CHRD_HUMAN, Q9H2X0
Function: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by
binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent
complexes (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHRD gene promoter:
         AP-1   STAT3   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CHRD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHRD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27

CHRD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHRD gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P184097:  view genomic region     (about GC identifiers)

Start:
184,097,861 bp from pter      End:
184,108,524 bp from pter
Size:
10,664 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHRD_HUMAN, Q9H2X0 (See protein sequence)
Recommended Name: Chordin precursor  
Size: 955 amino acids; 102032 Da
Subunit: Interacts with TWSG1 and/or BMP4 (By similarity)
Subcellular location: Secreted (By similarity)
Secondary accessions: O95254 Q2M1I8 Q6UW83 Q9H2D3 Q9H2W8 Q9H2W9 Q9P0Z2 Q9P0Z3 Q9P0Z4 Q9P0Z5
Alternative splicing: 5 isoforms:  Q9H2X0-1   Q9H2X0-2   Q9H2X0-3   Q9H2X0-4   Q9H2X0-5   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CHRD: NX_Q9H2X0

Explore proteomics data for CHRD at MOPED 

Post-translational modifications:

  • UniProtKB: Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development (By
    similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2X0

  • CHRD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHRD Protein Expression
    REFSEQ proteins: NP_003732.2  
    ENSEMBL proteins: 
     ENSP00000348930   ENSP00000204604   ENSP00000408624   ENSP00000392794   ENSP00000408972  
     ENSP00000334036   ENSP00000308559   ENSP00000442948  

    Human Recombinant Protein Products for CHRD: 
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    OriGene Protein Over-expression Lysate for CHRD
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    Novus Biologicals CHRD Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHRD 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space NAS16449796

    CHRD for ontologies           About GeneDecksing



    CHRD Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CHRD 

    Assay Products for CHRD: 
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    Cloud-Clone Corp. ELISAs for CHRD 
    Cloud-Clone Corp. CLIAs for CHRD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR016353 Chordin
     IPR010895 CHRD
     IPR001007 VWF_C

    Graphical View of Domain Structure for InterPro Entry Q9H2X0

    ProtoNet protein and cluster: Q9H2X0

    2 Blocks protein domains:
    IPB001007 von Willebrand factor
    IPB010895 CHRD


    UniProtKB/Swiss-Prot: CHRD_HUMAN, Q9H2X0
    Similarity: Belongs to the chordin family
    Similarity: Contains 4 CHRD domains
    Similarity: Contains 4 VWFC domains


    CHRD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHRD_HUMAN, Q9H2X0
    Function: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by
    binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent
    complexes (By similarity)

         Genatlas biochemistry entry for CHRD:
    chordin,developmental protein,highly conserved,inhibiting the ventralizing activity of bone morphogenetic
    proteins,active during gastrulation,expressed in fetal and adult liver and cerebellum

         Summary:
    During embryonic development, CHRD as signaling molecule is secreted from the following cells: Early-Gastrula Organizer in Epiblast, Prechordal Plate Cells in Prechordal Plate (see all 3).

    It affects the following cells: Intraembryonic Ectoderm Cells in Ectoderm, Intraembryonic Neural Ectoderm Cells in Neural Plate (see all 3).

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008201heparin binding IEA--
    GO:0019955cytokine binding NAS16449796
    GO:0045545syndecan binding IEA--
         
    CHRD for ontologies           About GeneDecksing


    Phenotypes:
         15/21 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chrd) (see all 21):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle  nervous system 

    CHRD for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHRD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHRD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHRD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHRD 

    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRD (see all 26):
    hsa-let-7d hsa-miR-575 hsa-let-7a-2* hsa-miR-486-3p hsa-let-7c hsa-miR-515-5p hsa-let-7g hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCHRD 3' UTR sequence
    Inhib. RNA
    Products:
        
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHRD About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by BMP
    BMP receptor signaling0.31
    2TGF-beta signaling pathway
    TGF-beta signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CHRD
        BMP receptor signaling


    1         Kegg Pathway  (Kegg details for CHRD):
        TGF-beta signaling pathway


    CHRD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHRD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for CHRD (Q9H2X01, 2, 3 ENSP000002046044) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMP1P134972, 3, ENSP000003057144MINT-7386098 I2D: score=4 STRING: ENSP00000305714
    ATN1P542592, 3, ENSP000003490764MINT-2865426 MINT-2865407 I2D: score=3 STRING: ENSP00000349076
    TLL1O438973, ENSP000000612404I2D: score=4 STRING: ENSP00000061240
    TWSG1Q9GZX93, ENSP000002621204I2D: score=3 STRING: ENSP00000262120
    ABL1P005193, ENSP000003614234I2D: score=1 STRING: ENSP00000361423
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001501skeletal system development TAS9782094
    GO:0001649osteoblast differentiation IEA--
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0001707mesoderm formation IEA--
    GO:0002053positive regulation of mesenchymal cell proliferation IMP18533030

    CHRD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHRD for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHRD

    7 Novoseek inferred chemical compound relationships for CHRD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    admp 87.4 3 16933975 (1), 10640703 (1), 19733655 (1)
    astacin 66.5 1 19723501 (1)
    procollagen 59.3 14 15381708 (4), 18542833 (3), 15817489 (2), 10952893 (1) (see all 5)
    oligonucleotide 0 1 12629212 (1)
    zinc 0 1 9435279 (1)
    retinoic acid 0 2 12975341 (1), 8850563 (1)
    cysteine 0 1 15082551 (1)

    Search CenterWatch for drugs/clinical trials and news about CHRD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHRD gene (3 alternative transcripts): 
    NM_003741.2  NM_177978.1  NM_177979.1  

    Unigene Cluster for CHRD:

    Chordin
    Hs.166186  [show with all ESTs]
    Unigene Representative Sequence: AF209930
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000356534 ENST00000204604(uc003fov.3 uc003fox.3) ENST00000448472(uc003fow.3)
    ENST00000420973(uc003foy.3) ENST00000460627(uc011brr.2) ENST00000450923
    ENST00000348986(uc010hyc.3) ENST00000470150 ENST00000496527 ENST00000459711
    ENST00000485883 ENST00000482805 ENST00000486066 ENST00000461684 ENST00000482014
    ENST00000461120 ENST00000464833 ENST00000310236
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHRD
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate CHRD (see all 26):
    hsa-let-7d hsa-miR-575 hsa-let-7a-2* hsa-miR-486-3p hsa-let-7c hsa-miR-515-5p hsa-let-7g hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCHRD 3' UTR sequence
    Inhib. RNA
    Products:
         
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    GenScript: all cDNA clones in your preferred vector: CHRD (NM_003741)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHRD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHRD
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                         Customized lentivirus expression plasmids for stable overexpression of CHRD 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHRD

    Additional mRNA sequence: 

    AF038198.1 AF076612.1 AF209928.1 AF209930.1 AF283325.1 AK293456.1 AK295632.1 AK296316.1 
    AK300213.1 AK300476.1 AY358926.1 BC029879.1 BC112345.1 BC114923.1 

    6 DOTS entries:

    DT.95371416  DT.40214912  DT.120884963  DT.100765134  DT.100765131  DT.120884951 

    24/51 AceView cDNA sequences (see all 51):

    NM_177979 AI370796 NM_003741 AF209928 BC029879 CK904519 AF209930 BQ778474 
    BM023317 BQ776386 AV647036 NM_177978 BQ006677 Z41391 AF283325 AF209929 
    BE872081 CB216920 CF552280 BM547128 AY358926 AF038198 BI820465 BM023627 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CHRD (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^
    SP1:                                -           -                 -                       -           -     -                       -     -                     
    SP2:                                -     -     -                 -                       -           -     -                       -                           
    SP3:                                -     -     -                 -                       -           -     -                       -                           
    SP4:                                -     -     -                 -                       -           -     -                       -     -                     
    SP5:                                -     -     -                 -                       -           -     -                                                   

    ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b
    SP1:                                            -                                       
    SP2:                                            -                                       
    SP3:                                            -                                       
    SP4:                                            -                                       
    SP5:                                            -     -                                 


    ECgene alternative splicing isoforms for CHRD

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHRD expression in normal human tissues (normalized intensities)      CHRD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGGCTGATG
    CHRD Expression
    About this image


    CHRD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 11 entries
             Articular Cartilage Cells Zeugopod Articular Cartilage
     
     Limb (Muscoskeletal System)    fully expand to see all 8 entries
             Central Intermediate Lamina Cells Zeugopod Synovial Joint
             limb/hindlimb   
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             cerebellum   
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 6 entries
             Prechordal Plate Cells Prechordal Plate
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon

    See CHRD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHRD

    SOURCE GeneReport for Unigene cluster: Hs.166186

    UniProtKB/Swiss-Prot: CHRD_HUMAN, Q9H2X0
    Tissue specificity: Expressed at the highest level in liver

        SABiosciences Expression via Pathway-Focused PCR Arrays including CHRD: 
              Osteogenesis in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHRD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHRD gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chrd1 , 5 chordin1, 5 85.89(n)1
    87.3(a)1
      16 (12.51 cM)5
    126671  NM_009893.21  NP_034023.11 
     207331275 
    chicken
    (Gallus gallus)
    Aves CHRD1 chordin 64.69(n)
    58.39(a)
      395828  NM_204980.1  NP_990311.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHRD6
    chordin
    52(a)
    1 ↔ 1
    GL343504.1(367719-435343)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980452 chordin 73.03(n)    L35764.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chd2 chordin 74.44(n)   30161  AF034606.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta sog1 , 3 terminal region determination growth
    factor3
    short gastrulation1
    29(a)3
    45.09(n)1
    32.3(a)1
      1 13E13
    324981  NM_057388.21  NP_476736.11 


    ENSEMBL Gene Tree for CHRD (if available)
    TreeFam Gene Tree for CHRD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHRD gene
    CHRDL12  CHRDL22  
    1 SIMAP similar gene for CHRD using alignment to 3 protein entries:     CHRD_HUMAN (see all proteins):
    FLJ00220

    CHRD for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/354 SNPs in CHRD are shown (see all 354)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1405599641,2
    F--184098526(+) TGGCAC/TCCGGA 2 H syn11Minor allele frequency- T:0.00NA 3844
    rs98801981,2
    C--184098559(+) ATGCGC/TTGCGT 2 R syn12Minor allele frequency- T:0.00NA 4
    rs1905222801,2
    --184098562(+) CGCTGC/TGTGCT 2 C syn10--------
    rs8856501,2
    C,A--184098647(-) ACTCCG/AACGCC 1 -- int14Minor allele frequency- A:0.14CSA WA NA EA 360
    rs1120918241,2
    C,F--184098711(+) CTGGTG/AGAGGA 1 -- int12Minor allele frequency- A:0.04WA 120
    rs1508927721,2
    --184098714(+) GTGGAA/GGAAGG 1 -- int10--------
    rs1114891701,2
    C--184098796(+) GTTTCA/G/TTTCCC 1 -- int11CSA 2
    rs8856581,2
    C--184098954(-) GGCAAG/AGATGT 1 -- int12Minor allele frequency- A:0.00NA 4
    rs1116211081,2
    C,F--184098956(+) ATCCTG/TGCCTG 1 -- int11Minor allele frequency- T:0.00CSA 1
    rs791039461,2
    C--184098994(+) ACTCAC/GTTGGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CHRD (184097861 - 184108524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CHRD:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422400CNV Duplication17116639
    nsv878060CNV Loss21882294
    nsv518580CNV Loss19592680
    esv25970CNV Loss19812545
    nsv829813CNV Loss17160897
    nsv511206CNV Gain21212237

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603475    OMIM disorders: --

    7 diseases for CHRD:    About MalaCards
    hepatoerythropoietic porphyria    cornelia de lange syndrome    porphyria    holoprosencephaly
    hypoxia    neuroblastoma    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for CHRD:
    Holoprosencephaly

    CHRD for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CHRD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 1.29 4 16449796 (2)
    cancer 0.921 6 16449796 (3)

    Genetic Association Database (GAD): CHRD
    Human Genome Epidemiology (HuGE) Navigator: CHRD (6 documents)

    Export disorders for CHRD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHRD gene, integrated from 9 sources (see all 175):
    (articles sorted by number of sources associating them with CHRD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coding sequence and expression patterns of mouse chordin and mapping of the cognate mouse chrd and human CHRD genes. (PubMed id 9782094)1, 2, 3, 9 Pappano W.N....Greenspan D.S. (1998)
    2. The human chordin gene encodes several differentially expressed spliced variants with distinct BMP opposing activities. (PubMed id 11472837)1, 2, 3, 9 Millet C....Francois V. (2001)
    3. BMP-binding modules in chordin: a model for signalling regulation in the extracellular space. (PubMed id 10648240)1, 2, 9 Larrain J....De Robertis E.M. (2000)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    6. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Chordin is underexpressed in ovarian tumors and reduces tumor cell motility. (PubMed id 16449796)1, 9 Moll F....Francois V. (2006)
    10. Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells. (PubMed id 18533030)1, 9 Kwong F.N....Evans C.H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8646 HGNC: 1949 AceView: CHRD Ensembl:ENSG00000090539 euGenes: HUgn8646
    ECgene: CHRD Kegg: 8646 H-InvDB: CHRD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHRD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHRD gene:
    Search GeneIP for patents involving CHRD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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