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Aliases for CHRAC1 Gene

Aliases for CHRAC1 Gene

  • Chromatin Accessibility Complex 1 2 3 5
  • Chromatin Accessibility Complex 15 KDa Protein 3 4
  • DNA Polymerase Epsilon Subunit P15 3 4
  • Histone-Fold Protein CHRAC15 2 3
  • CHRAC-15 3 4
  • CHRAC-1 3 4
  • CHRAC15 3 4
  • HuCHRAC15 4
  • CHARC15 3
  • CHARC1 3
  • YCL1 3

External Ids for CHRAC1 Gene

Previous GeneCards Identifiers for CHRAC1 Gene

  • GC08P141708
  • GC08P141205
  • GC08P141492
  • GC08P141590
  • GC08P141521
  • GC08P136832

Summaries for CHRAC1 Gene

Entrez Gene Summary for CHRAC1 Gene

  • CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

GeneCards Summary for CHRAC1 Gene

CHRAC1 (Chromatin Accessibility Complex 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for CHRAC1 Gene

  • Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRAC1 Gene

Genomics for CHRAC1 Gene

Regulatory Elements for CHRAC1 Gene

Promoters for CHRAC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHRAC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHRAC1 Gene

Chromosome:
8
Start:
140,511,298 bp from pter
End:
140,517,153 bp from pter
Size:
5,856 bases
Orientation:
Plus strand

Genomic View for CHRAC1 Gene

Genes around CHRAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRAC1 Gene

Proteins for CHRAC1 Gene

  • Protein details for CHRAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRG0-CHRC1_HUMAN
    Recommended name:
    Chromatin accessibility complex protein 1
    Protein Accession:
    Q9NRG0

    Protein attributes for CHRAC1 Gene

    Size:
    131 amino acids
    Molecular mass:
    14711 Da
    Quaternary structure:
    • Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

neXtProt entry for CHRAC1 Gene

Proteomics data for CHRAC1 Gene at MOPED

Post-translational modifications for CHRAC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHRAC1 Gene

Antibody Products

No data available for DME Specific Peptides for CHRAC1 Gene

Domains & Families for CHRAC1 Gene

Protein Domains for CHRAC1 Gene

Suggested Antigen Peptide Sequences for CHRAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHRAC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CHRAC1 Gene

Function for CHRAC1 Gene

Molecular function for CHRAC1 Gene

UniProtKB/Swiss-Prot Function:
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

Gene Ontology (GO) - Molecular Function for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003887 DNA-directed DNA polymerase activity NAS 10880450
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with CHRAC1: view
genes like me logo Genes that share phenotypes with CHRAC1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHRAC1 Gene

Localization for CHRAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRAC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHRAC1 Gene COMPARTMENTS Subcellular localization image for CHRAC1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for CHRAC1 Gene

Pathways & Interactions for CHRAC1 Gene

SuperPathways for CHRAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHRAC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CHRAC1 Gene

Drugs & Compounds for CHRAC1 Gene

No Compound Related Data Available

Transcripts for CHRAC1 Gene

Unigene Clusters for CHRAC1 Gene

Chromatin accessibility complex 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRAC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for CHRAC1 Gene

GeneLoc Exon Structure for
CHRAC1
ECgene alternative splicing isoforms for
CHRAC1

Expression for CHRAC1 Gene

mRNA expression in normal human tissues for CHRAC1 Gene

Protein differential expression in normal tissues from HIPED for CHRAC1 Gene

This gene is overexpressed in Pancreas (25.7) and Lung (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHRAC1 Gene



SOURCE GeneReport for Unigene cluster for CHRAC1 Gene Hs.279704

mRNA Expression by UniProt/SwissProt for CHRAC1 Gene

Q9NRG0-CHRC1_HUMAN
Tissue specificity: Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with CHRAC1: view

Protein tissue co-expression partners for CHRAC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHRAC1 Gene

Orthologs for CHRAC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRAC1 35
  • 92.56 (n)
  • 89.15 (a)
CHRAC1 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHRAC1 36
  • 87 (a)
OneToOne
CHRAC1 35
  • 88.59 (n)
  • 90.99 (a)
dog
(Canis familiaris)
Mammalia CHRAC1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chrac1 16
Chrac1 36
  • 79 (a)
OneToOne
Chrac1 35
  • 87.23 (n)
  • 86.92 (a)
oppossum
(Monodelphis domestica)
Mammalia CHRAC1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRAC1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chrac1 35
  • 87.23 (n)
  • 88.79 (a)
chicken
(Gallus gallus)
Aves CHRAC1 35
  • 79.04 (n)
  • 84.37 (a)
CHRAC1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHRAC1 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrac1 35
  • 75.44 (n)
  • 78.95 (a)
Str.1765 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4122 35
zebrafish
(Danio rerio)
Actinopterygii chrac1 36
  • 61 (a)
OneToOne
chrac1 35
  • 60.94 (n)
  • 64.65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007481 35
  • 54.68 (n)
  • 44.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta Chrac-16 36
  • 29 (a)
OneToOne
Species with no ortholog for CHRAC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHRAC1 Gene

ENSEMBL:
Gene Tree for CHRAC1 (if available)
TreeFam:
Gene Tree for CHRAC1 (if available)

Paralogs for CHRAC1 Gene

(2) SIMAP similar genes for CHRAC1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CHRAC1 Gene

genes like me logo Genes that share paralogs with CHRAC1: view

No data available for Paralogs for CHRAC1 Gene

Variants for CHRAC1 Gene

Sequence variations from dbSNP and Humsavar for CHRAC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2231522 - 140,514,385(+) TCAAT(A/G)CCTAG intron-variant, nc-transcript-variant, reference, missense
rs2231524 - 140,515,228(+) TGACC(A/G)TGATG nc-transcript-variant, reference, missense
rs2231512 -- 140,510,807(+) CTCGG(A/C)GCAGT upstream-variant-2KB
rs2231513 -- 140,510,815(+) AGTCC(C/G)GAAGA upstream-variant-2KB
rs2231514 -- 140,510,929(+) CCCGC(A/C)GCATC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHRAC1 Gene

Variant ID Type Subtype PubMed ID
esv2737756 CNV Deletion 23290073
nsv509283 CNV Insertion 20534489
nsv465951 CNV Loss 19166990
nsv891531 CNV Loss 21882294

Variation tolerance for CHRAC1 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRAC1 Gene

HapMap Linkage Disequilibrium report
CHRAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRAC1 Gene

Disorders for CHRAC1 Gene

Relevant External Links for CHRAC1

Genetic Association Database (GAD)
CHRAC1
Human Genome Epidemiology (HuGE) Navigator
CHRAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRAC1

No disorders were found for CHRAC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRAC1 Gene

Publications for CHRAC1 Gene

  1. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. (PMID: 10880450) Poot R.A. … Varga-Weisz P.D. (EMBO J. 2000) 2 3 4 67
  2. Cloning and characterization of the histone-fold proteins YBL1 and YCL1. (PMID: 11000277) Bolognese F. … Mantovani R. (Nucleic Acids Res. 2000) 2 3 23
  3. The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. (PMID: 14759371) Kukimoto I. … Varga-Weisz P.D. (Mol. Cell 2004) 3 23
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation. (PMID: 24148822) Mahmood S.F. … Bernard-Pierrot I. (Carcinogenesis 2014) 3

Products for CHRAC1 Gene

Sources for CHRAC1 Gene

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