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Aliases for CHRAC1 Gene

Aliases for CHRAC1 Gene

  • Chromatin Accessibility Complex 1 2 3 5
  • Chromatin Accessibility Complex 15 KDa Protein 3 4
  • DNA Polymerase Epsilon Subunit P15 3 4
  • Histone-Fold Protein CHRAC15 2 3
  • CHRAC-15 3 4
  • CHRAC-1 3 4
  • CHRAC15 3 4
  • Chromatin Accessibility Complex Protein 1 3
  • HuCHRAC15 4
  • CHARC15 3
  • CHARC1 3
  • YCL1 3

External Ids for CHRAC1 Gene

Previous GeneCards Identifiers for CHRAC1 Gene

  • GC08P141708
  • GC08P141205
  • GC08P141492
  • GC08P141590
  • GC08P141521
  • GC08P136832

Summaries for CHRAC1 Gene

Entrez Gene Summary for CHRAC1 Gene

  • CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004]

GeneCards Summary for CHRAC1 Gene

CHRAC1 (Chromatin Accessibility Complex 1) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding and DNA-directed DNA polymerase activity.

UniProtKB/Swiss-Prot for CHRAC1 Gene

  • Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHRAC1 Gene

Genomics for CHRAC1 Gene

Regulatory Elements for CHRAC1 Gene

Enhancers for CHRAC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G140506 1.5 Ensembl ENCODE dbSUPER 38.3 -3.2 -3247 2.8 PKNOX1 ATF1 SIN3A ZNF121 ZNF766 ZNF143 DEK ZNF263 JUNB MIER2 CHRAC1 ENSG00000259891 GC08M140501
GH08G140509 1.4 ENCODE dbSUPER 27.2 +0.7 657 4.4 HDGF CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B CHRAC1 GC08P140525
GH08G140596 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +87.0 86992 4.5 HDGF ATF1 WRNIP1 SIN3A FEZF1 FOS JUNB TBX21 SMARCA4 MYNN AGO2 CHRAC1 TRAPPC9 GC08P140597 ERICD
GH08G140456 1.4 ENCODE dbSUPER 16.6 -52.5 -52519 4.8 FEZF1 YBX1 ZNF143 ZNF263 SP3 NFYC TBX21 MEF2D GLIS1 NBN CHRAC1 AGO2 TRAPPC9 ENSG00000259891 PIR60466
GH08G140516 0.4 dbSUPER 52.6 +3.8 3797 1.8 FOS MLLT1 CHRAC1 GC08P140525
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHRAC1 on UCSC Golden Path with GeneCards custom track

Promoters for CHRAC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000231719 102 2401 HDGF CREB3L1 ARNT AGO1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B

Genomic Location for CHRAC1 Gene

Chromosome:
8
Start:
140,511,298 bp from pter
End:
140,517,153 bp from pter
Size:
5,856 bases
Orientation:
Plus strand

Genomic View for CHRAC1 Gene

Genes around CHRAC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHRAC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHRAC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHRAC1 Gene

Proteins for CHRAC1 Gene

  • Protein details for CHRAC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRG0-CHRC1_HUMAN
    Recommended name:
    Chromatin accessibility complex protein 1
    Protein Accession:
    Q9NRG0

    Protein attributes for CHRAC1 Gene

    Size:
    131 amino acids
    Molecular mass:
    14711 Da
    Quaternary structure:
    • Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.

neXtProt entry for CHRAC1 Gene

Post-translational modifications for CHRAC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHRAC1 Gene

No data available for DME Specific Peptides for CHRAC1 Gene

Domains & Families for CHRAC1 Gene

Protein Domains for CHRAC1 Gene

Suggested Antigen Peptide Sequences for CHRAC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHRAC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CHRAC1 Gene

Function for CHRAC1 Gene

Molecular function for CHRAC1 Gene

UniProtKB/Swiss-Prot Function:
Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.

Gene Ontology (GO) - Molecular Function for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 10880450
GO:0003887 DNA-directed DNA polymerase activity NAS 10880450
GO:0005515 protein binding IPI 21516116
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with CHRAC1: view
genes like me logo Genes that share phenotypes with CHRAC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHRAC1 Gene

Localization for CHRAC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHRAC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHRAC1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0008622 epsilon DNA polymerase complex NAS 10880450
GO:0008623 CHRAC NAS 10880450
genes like me logo Genes that share ontologies with CHRAC1: view

Pathways & Interactions for CHRAC1 Gene

SuperPathways for CHRAC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHRAC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling NAS 10880450
GO:0071897 DNA biosynthetic process IEA --
genes like me logo Genes that share ontologies with CHRAC1: view

No data available for Pathways by source and SIGNOR curated interactions for CHRAC1 Gene

Transcripts for CHRAC1 Gene

Unigene Clusters for CHRAC1 Gene

Chromatin accessibility complex 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHRAC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for CHRAC1 Gene

GeneLoc Exon Structure for
CHRAC1
ECgene alternative splicing isoforms for
CHRAC1

Expression for CHRAC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHRAC1 Gene

Protein differential expression in normal tissues from HIPED for CHRAC1 Gene

This gene is overexpressed in Pancreas (25.7) and Lung (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHRAC1 Gene



Protein tissue co-expression partners for CHRAC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHRAC1 Gene:

CHRAC1

SOURCE GeneReport for Unigene cluster for CHRAC1 Gene:

Hs.279704

mRNA Expression by UniProt/SwissProt for CHRAC1 Gene:

Q9NRG0-CHRC1_HUMAN
Tissue specificity: Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with CHRAC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHRAC1 Gene

Orthologs for CHRAC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHRAC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHRAC1 34 35
  • 92.56 (n)
cow
(Bos Taurus)
Mammalia CHRAC1 34 35
  • 88.59 (n)
mouse
(Mus musculus)
Mammalia Chrac1 34 16 35
  • 87.23 (n)
rat
(Rattus norvegicus)
Mammalia Chrac1 34
  • 87.23 (n)
dog
(Canis familiaris)
Mammalia CHRAC1 35
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHRAC1 35
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHRAC1 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHRAC1 34 35
  • 79.04 (n)
lizard
(Anolis carolinensis)
Reptilia CHRAC1 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chrac1 34
  • 75.44 (n)
Str.1765 34
zebrafish
(Danio rerio)
Actinopterygii chrac1 34 35
  • 60.94 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4122 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007481 34
  • 54.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta Chrac-16 35
  • 29 (a)
OneToOne
Species where no ortholog for CHRAC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHRAC1 Gene

ENSEMBL:
Gene Tree for CHRAC1 (if available)
TreeFam:
Gene Tree for CHRAC1 (if available)

Paralogs for CHRAC1 Gene

(2) SIMAP similar genes for CHRAC1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CHRAC1 Gene

genes like me logo Genes that share paralogs with CHRAC1: view

No data available for Paralogs for CHRAC1 Gene

Variants for CHRAC1 Gene

Sequence variations from dbSNP and Humsavar for CHRAC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000079419 -- 140,512,063(+) TCCCT(C/G/T)CCACC intron-variant
rs1000404144 -- 140,510,526(+) CTCTC(C/T)TCCCA upstream-variant-2KB
rs1000414246 -- 140,510,264(+) TGGGT(A/G)GCGCG upstream-variant-2KB
rs1000536307 -- 140,511,879(+) TTCTC(C/T)AGTTT intron-variant, upstream-variant-2KB
rs1001281777 -- 140,515,946(+) CAAAA(A/G)TAAGT nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CHRAC1 Gene

Variant ID Type Subtype PubMed ID
dgv12367n54 CNV gain 21841781
esv2737756 CNV deletion 23290073
esv3619033 CNV gain 21293372
nsv1016282 CNV gain 25217958
nsv1126125 CNV deletion 24896259
nsv465951 CNV loss 19166990
nsv509283 CNV insertion 20534489
nsv612566 CNV loss 21841781

Variation tolerance for CHRAC1 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.45; 43.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHRAC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHRAC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHRAC1 Gene

Disorders for CHRAC1 Gene

Relevant External Links for CHRAC1

Genetic Association Database (GAD)
CHRAC1
Human Genome Epidemiology (HuGE) Navigator
CHRAC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHRAC1

No disorders were found for CHRAC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHRAC1 Gene

Publications for CHRAC1 Gene

  1. Cloning and characterization of the histone-fold proteins YBL1 and YCL1. (PMID: 11000277) Bolognese F. … Mantovani R. (Nucleic Acids Res. 2000) 2 3 22 64
  2. HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. (PMID: 10880450) Poot R.A. … Varga-Weisz P.D. (EMBO J. 2000) 2 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. (PMID: 14759371) Kukimoto I. … Varga-Weisz P.D. (Mol. Cell 2004) 3 22 64

Products for CHRAC1 Gene

Sources for CHRAC1 Gene

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