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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHPT1 Gene

protein-coding   GIFtS: 57
GCID: GC12P102090

choline phosphotransferase 1

 Explore 6 diseases affiliated with
CHPT1 via our new
 Human Malady Compendium 
Biological research products
for CHPT1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Choline Phosphotransferase 11 2     CPT2
CPT11 2 3     Cholinephosphotransferase 12
Diacylglycerol Cholinephosphotransferase 12 3     Cholinephosphotransferase 1 Alpha2
AAPT1-Like Protein2 3     Phosphatidylcholine Synthesizing Enzyme2
HCPT11     EC 2.7.88
EC 2.7.8.23 8     

External Ids:    HGNC: 178521   Entrez Gene: 569942   Ensembl: ENSG000001116667   UniProtKB: Q8WUD63   

Export aliases for CHPT1 gene to outside databases

Previous GC identifers: GC12P101225 GC12P102074 GC12P100593 GC12P099151


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CHPT1_HUMAN, Q8WUD6
Function: Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation
and maintenance of vesicular membranes




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHPT1 gene promoter:
         AML1a   SREBP-1c   Cdc5   SREBP-1b   MEF-2A   S8   SREBP-1a   ARP-1   Msx-1   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHPT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHPT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHPT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q

CHPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHPT1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P102090:  view genomic region     (about GC identifiers)

Start:
102,090,725 bp from pter      End:
102,137,918 bp from pter
Size:
47,194 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHPT1_HUMAN, Q8WUD6 (See protein sequence)
Recommended Name: Cholinephosphotransferase 1  
Size: 406 amino acids; 45097 Da
Cofactor: Magnesium or manganese
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAD44019.1; Type=Frameshift; Positions=310; Sequence=AAL39005.1; Type=Erroneous initiation;
Secondary accessions: B3KQM2 Q7Z7H0 Q7Z7H1 Q7Z7H2 Q8IWQ4 Q8IWQ5 Q8WYI4 Q9NRQ6 Q9NRQ7 Q9Y6M6
Alternative splicing: 2 isoforms:  Q8WUD6-1   Q8WUD6-2   

Explore the universe of human proteins at neXtProt for CHPT1: NX_Q8WUD6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8WUD6

  • 4/9 DME Specific Peptides for CHPT1 (Q8WUD6) (see all 9)
     AHMTKSE  PLWMAPN  WTYLLCA  GGVGKNGST 

    CHPT1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064629.2  
    ENSEMBL proteins: 
     ENSP00000229266   ENSP00000448766   ENSP00000446994   ENSP00000447887   ENSP00000448831  
     ENSP00000447920   ENSP00000448369  
    Reactome Protein details: Q8WUD6
    Human Recombinant Protein Products: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CHPT1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005792microsome ----
    GO:0005794Golgi apparatus ----
    GO:0016020membrane NAS10893425
    GO:0016021integral to membrane IEA--


    CHPT1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CHPT1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR014472 CHOPT
     IPR000462 CDP-OH_P_trans

    Graphical View of Domain Structure for InterPro Entry Q8WUD6

    ProtoNet protein and cluster: Q8WUD6

    2 Blocks protein families:
    IPB000462 CDP-alcohol phosphatidyltransferase
    IPB003016 2-oxo acid dehydrogenase


    UniProtKB/Swiss-Prot: CHPT1_HUMAN, Q8WUD6
    Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CHPT1_HUMAN, Q8WUD6
    Function: Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation
    and maintenance of vesicular membranes
    Catalytic activity: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine

    Enzyme Numbers (IUBMB): EC 2.7.8.21 2 EC 2.7.82

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004142diacylglycerol cholinephosphotransferase activity TAS--
    GO:0016780phosphotransferase activity, for other substituted phosphate groups ----
    GO:0019992diacylglycerol binding NAS10893425
    GO:0046872metal ion binding IEA--


    CHPT1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CHPT1:
     Synthetic lethal with c-Myc af 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycerophospholipid biosynthesis
    Glycerophospholipid biosynthesis1.00
    Glycerophospholipid metabolism0.54
    Phospholipid metabolism0.64
    2Metabolism
    Metabolism1.00
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.38
    3choline biosynthesis III
    choline biosynthesis III1.00
    phosphatidylcholine biosynthesis I0.36
    4Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics1.00
    5alpha-Linolenic acid metabolism
    Ether lipid metabolism0.44

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for CHPT1 
        choline biosynthesis III
    phosphatidylcholine biosynthesis I

    5        Reactome Pathways for CHPT1
        Glycerophospholipid biosynthesis
    Metabolism
    Phospholipid metabolism
    Synthesis of PC
    Metabolism of lipids and lipoproteins

    1 PharmGKB Pathway for CHPT1
        Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics

    3         Kegg Pathways  (Kegg details for CHPT1):
        Glycerophospholipid metabolism
    Ether lipid metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: CHPT1_HUMAN, Q8WUD6
    Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2


    CHPT1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHPT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for CHPT1 (Q8WUD63 ENSP000002292664) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    REC8O950723I2D: score=1 
    SMC1BQ8NDV33I2D: score=1 
    SMC3Q9UQE73I2D: score=1 
    DGKHENSP000003375724STRING: ENSP00000337572
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth NAS10893425
    GO:0006629lipid metabolic process TAS10893425
    GO:0006644phospholipid metabolic process TAS--
    GO:0006656phosphatidylcholine biosynthetic process TAS--
    GO:0006657CDP-choline pathway NAS10893425


    CHPT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHPT1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHPT1

    10/1983 HMDB Compounds for CHPT1 (see all 1983)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Argininosuccinic acidArgininosuccinate (see all 27)2387-71-58382048
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    PC(O-16:0/18:2(9Z,12Z))1-hexadecyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine (see all 5)88542-95-412486725
    CiticolineAudes (see all 43)987-78-0--
    Cytidine monophosphate5'-CMP (see all 14)63-37-6--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    10/19 Novoseek chemical compound relationships for CHPT1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cdp choline 91.3 9 12221122 (2), 10191259 (1), 17213183 (1), 1333282 (1) (see all 8)
    cdp ethanolamine 91.1 3 1333282 (2), 12221122 (1)
    diradylglycerol 85.8 1 12216837 (1)
    phosphatidylcholine 81.3 39 8240288 (2), 8037660 (2), 12221122 (2), 15936720 (2) (see all 17)
    plasmenylcholine 80.6 6 8037660 (2), 8382961 (2)
    phosphorylcholine 75.2 4 10191259 (1), 17920136 (1), 1951666 (1), 10893425 (1)
    choline 69.2 8 12216837 (1), 2171666 (1), 10191259 (1), 8044894 (1) (see all 6)
    phosphatidylethanolamine 62.7 3 12221122 (2), 1333282 (1)
    1,2-diacylglycerol 61.9 1 10907782 (1)
    ethanolamine 57.3 3 12216837 (1), 10191259 (1)

    Search CenterWatch for drugs/clinical trials and news about CHPT1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHPT1 gene: 
    NM_020244.2  

    Unigene Cluster for CHPT1:

    Choline phosphotransferase 1
    Hs.293077  [show with all ESTs]
    Unigene Representative Sequence: AK226127
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000550385 ENST00000229266(uc001tin.3 uc001tio.3) ENST00000549872
    ENST00000549128 ENST00000552351 ENST00000546490 ENST00000552215(uc001tip.1)
    ENST00000552329 ENST00000546873 ENST00000552213

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    Additional cDNA sequence: 

    AF047431.1 AF111803.1 AF195623.1 AK025141.1 AK075211.1 AK093067.1 AK226127.1 AY166717.1 
    AY166718.1 AY280609.1 AY280610.1 AY294627.1 BC020819.1 BC050429.1 

    15 DOTS entries:

    DT.440957  DT.100818423  DT.456021  DT.100818421  DT.427414  DT.121178791  DT.40250754  DT.100818425 
    DT.121178820  DT.121178844  DT.40205143  DT.40212542  DT.95184125  DT.95184095  DT.95258155 

    24/220 AceView cDNA sequences (see all 220):

    CD244130 CR621563 CK430226 BX487426 NM_020244 AY280609 CR590259 H20058 
    CR608650 BC050429 AI049761 CR596586 BF223084 CD107653 BQ010936 AI493671 
    AI423579 CR592188 BC020819 BE326894 BF724709 AF111803 BF724252 AI478541 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CHPT1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
    SP1:                                      -           -                                   -         
    SP2:                                      -           -                                             
    SP3:                                      -                                                         
    SP4:        -     -                                                                                 


    ECgene alternative splicing isoforms for CHPT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHPT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAGGAGATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CHPT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHPT1

    SOURCE GeneReport for Unigene cluster: Hs.293077

    UniProtKB/Swiss-Prot: CHPT1_HUMAN, Q8WUD6
    Tissue specificity: Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in
    kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung.
    Overexpressed in cancerous breast epithelial cell lines

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHPT1 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chpt11 , 5 choline phosphotransferase 11, 5 89.33(n)1
    89.41(a)1
      10 (43.93 cM)5
    2128621  NM_001146690.11  NP_001140162.11 
     884527455 
    chicken
    (Gallus gallus)
    Aves CHPT1_CHICK6
    Cholinephosphotransferase 1
    67(a)
    1 ↔ 1
    1(57623148-57640119)
    lizard
    (Anolis carolinensis)
    Reptilia CHPT16
    --
    70(a)
    1 ↔ 1
    5(17345868-17372041)
    zebrafish
    (Danio rerio)
    Actinopterygii chpt11 choline phosphotransferase 1 66.48(n)
    65.66(a)
      322605  NM_212624.1  NP_997789.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG60163 ethanolaminephosphotransferase 53(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea Y49A3A.13   -- 43(a)   V(14351464-14353490)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATAAPT26
    AAPT16
    ethanolaminephosphotransferase
    24(a)
    24(a)
    possible ortholog
    possible ortholog
    3(9295309-9298746)
    1(4638514-4642104)
    rice
    (Oryza sativa)
    Liliopsida --
    --
    CDP-alcohol phosphatidyltransferase, putative, exp...
    CDP-alcohol phosphatidyltransferase, putative, exp...
    24(a)
    20(a)
    possible ortholog
    possible ortholog
    2(1040528-1046183)
    6(5275591-5284927)


    ENSEMBL Gene Tree for CHPT1 (if available)
    TreeFam Gene Tree for CHPT1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHPT1 gene
    CEPT12  EPT12  
    3 SIMAP similar genes for CHPT1 using alignment to 5 protein entries:     CHPT1_HUMAN (see all proteins):
    CEPT1    EPT1    SELI

    CHPT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/532 NCBI SNPs in CHPT1 are shown (see all 532    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs26952821,2
    C,F,A,H,--102089502(-) CTCTGC/TTCCAA 1 -- us2k127Minor allele frequency- T:0.43NS EA NA WA CSA 2776
    rs25598561,2
    C,F,A,H,--102089561(-) GGCACT/CCCAAG 1 -- us2k110Minor allele frequency- C:0.43NA WA CSA EA 378
    rs769938931,2
    F,--102089631(+) CTGTGG/CTATTT 1 -- us2k11Minor allele frequency- C:0.05EA 120
    rs1807342171,2
    --102089658(+) GCTGAC/GTAATA 1 -- us2k10--------
    rs1860778461,2
    --102089882(+) GTTTAC/TGGCTT 1 -- us2k10--------
    rs1998143891,2
    C--102089888(+) GGCTTG/TTNNNN 1 -- us2k10--------
    rs769544871,2
    F,--102089910(+) ATGACG/ATCTTT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs26952811,2
    C,F,O,A,H,--102089999(-) TTTACC/TGATGC 1 -- us2k1101Minor allele frequency- N:0.00NS EA NA PA EU CA WA CSA 5334
    rs1913261291,2
    --102090045(+) AACCAA/GCATTG 1 -- us2k10--------
    rs1832060491,2
    --102090046(+) ACCAGA/CATTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHPT1 (102090725 - 102137918 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for CHPT1
         8 CNVs: 23043 101605 86544 39113 66315 61271 35032 76138

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHPT1
    DNA2.0 Custom Variant and Variant Library Synthesis for CHPT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CHPT1 for disorders           About GeneDecksing

    6 diseases for CHPT1:    About MalaCards
    renal cell carcinoma    breast cancer    carcinoma    prostatitis
    neuronitis    alcoholism

    1 disease from the University of Copenhagen DISEASES database for CHPT1:
    Newborn respiratory distress syndrome

    2 Novoseek disease relationships for CHPT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 5.63 1 12359261 (1)
    cancer 0 2 14651986 (1)


    Export disorders for CHPT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHPT1 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with CHPT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, genomic organization, and characterization of a human cholinephosphotransferase. (PubMed id 10893425)1, 2, 3, 9 Henneberry A.L.... McMaster C.R. (2000)
    2. Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells. (PubMed id 12359261)1, 2, 9 Ghosh A.... Das S.K. (2002)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist. (PubMed id 15936720)1, 9 Akech J....Das S.K. (2005)
    5. The major sites of cellular phospholipid synthesis and molecular determinants of fatty acid and lipid head group specificity. (PubMed id 12221122)2, 9 Henneberry A.L.... McMaster C.R. (2002)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. Inhibition of cholinephosphotransferase activity in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. (PubMed id 16292752)2 Sinha Roy S....Das S.K. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56994 HGNC: 17852 AceView: CHPT1 Ensembl:ENSG00000111666 euGenes: HUgn56994
    ECgene: CHPT1 Kegg: 56994 H-InvDB: CHPT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHPT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHPT1 gene:
    Search GeneIP for patents involving CHPT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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