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Aliases for CHPT1 Gene

Aliases for CHPT1 Gene

  • Choline Phosphotransferase 1 2 3
  • Diacylglycerol Cholinephosphotransferase 1 3 4
  • Phosphatidylcholine Synthesizing Enzyme 2 3
  • AAPT1-Like Protein 3 4
  • EC 2.7.8.2 4 63
  • HCPT1 3 4
  • CPT1 3 4
  • Cholinephosphotransferase 1 Alpha 3
  • Cholinephosphotransferase 1 3
  • EC 2.7.8 63
  • CPT 3

External Ids for CHPT1 Gene

Previous GeneCards Identifiers for CHPT1 Gene

  • GC12P101225
  • GC12P102074
  • GC12P100593
  • GC12P099151
  • GC12P102090

Summaries for CHPT1 Gene

GeneCards Summary for CHPT1 Gene

CHPT1 (Choline Phosphotransferase 1) is a Protein Coding gene. Diseases associated with CHPT1 include newborn respiratory distress syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include diacylglycerol binding and diacylglycerol cholinephosphotransferase activity. An important paralog of this gene is CEPT1.

UniProtKB/Swiss-Prot for CHPT1 Gene

  • Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHPT1 Gene

Genomics for CHPT1 Gene

Regulatory Elements for CHPT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHPT1 Gene

Start:
101,696,947 bp from pter
End:
101,744,140 bp from pter
Size:
47,194 bases
Orientation:
Plus strand

Genomic View for CHPT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHPT1 Gene

Proteins for CHPT1 Gene

  • Protein details for CHPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUD6-CHPT1_HUMAN
    Recommended name:
    Cholinephosphotransferase 1
    Protein Accession:
    Q8WUD6
    Secondary Accessions:
    • B3KQM2
    • Q7Z7H0
    • Q7Z7H1
    • Q7Z7H2
    • Q8IWQ4
    • Q8IWQ5
    • Q8WYI4
    • Q9NRQ6
    • Q9NRQ7
    • Q9Y6M6

    Protein attributes for CHPT1 Gene

    Size:
    406 amino acids
    Molecular mass:
    45097 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD44019.1; Type=Frameshift; Positions=310; Evidence={ECO:0000305}; Sequence=AAL39005.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHPT1 Gene

Proteomics data for CHPT1 Gene at MOPED

Post-translational modifications for CHPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHPT1 Gene

Domains for CHPT1 Gene

Suggested Antigen Peptide Sequences for CHPT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUD6

UniProtKB/Swiss-Prot:

CHPT1_HUMAN :
  • Q8WUD6
Family:
  • Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
genes like me logo Genes that share domains with CHPT1: view

No data available for Gene Families for CHPT1 Gene

Function for CHPT1 Gene

Molecular function for CHPT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: CDP-choline + 1,2-diacyl-sn-glycerol = CMP + a phosphatidylcholine.
UniProtKB/Swiss-Prot Function: Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes

Enzyme Numbers (IUBMB) for CHPT1 Gene

Gene Ontology (GO) - Molecular Function for CHPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004142 diacylglycerol cholinephosphotransferase activity TAS --
GO:0016780 phosphotransferase activity, for other substituted phosphate groups --
GO:0019992 diacylglycerol binding NAS 10893425
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CHPT1: view

Phenotypes for CHPT1 Gene

GenomeRNAi human phenotypes for CHPT1:
genes like me logo Genes that share phenotypes with CHPT1: view

Animal Model Products

CRISPR Products

miRNA for CHPT1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHPT1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for CHPT1 Gene

Localization for CHPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHPT1 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHPT1 Gene COMPARTMENTS Subcellular localization image for CHPT1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CHPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus --
GO:0016020 membrane NAS 10893425
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle NAS 10893425
genes like me logo Genes that share ontologies with CHPT1: view

Pathways for CHPT1 Gene

genes like me logo Genes that share pathways with CHPT1: view

UniProtKB/Swiss-Prot Q8WUD6-CHPT1_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2

Interacting Proteins for CHPT1 Gene

Gene Ontology (GO) - Biological Process for CHPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth NAS 10893425
GO:0006629 lipid metabolic process TAS 10893425
GO:0006644 phospholipid metabolic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway NAS 10893425
genes like me logo Genes that share ontologies with CHPT1: view

Compounds for CHPT1 Gene

(1983) HMDB Compounds for CHPT1 Gene

Compound Synonyms Cas Number PubMed IDs
Argininosuccinic acid
  • Argininosuccinate
2387-71-5
Citicoline
  • Audes
987-78-0
Cytidine monophosphate
  • 5'-CMP
63-37-6
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(19) Novoseek inferred chemical compound relationships for CHPT1 Gene

Compound -log(P) Hits PubMed IDs
cdp choline 91.3 9
cdp ethanolamine 91.1 3
diradylglycerol 85.8 1
phosphatidylcholine 81.3 23
plasmenylcholine 80.6 4
genes like me logo Genes that share compounds with CHPT1: view

Transcripts for CHPT1 Gene

Unigene Clusters for CHPT1 Gene

Choline phosphotransferase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHPT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHPT1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12
SP1: - - -
SP2: - -
SP3: -
SP4: - -

Relevant External Links for CHPT1 Gene

GeneLoc Exon Structure for
CHPT1
ECgene alternative splicing isoforms for
CHPT1

Expression for CHPT1 Gene

mRNA expression in normal human tissues for CHPT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHPT1 Gene

SOURCE GeneReport for Unigene cluster for CHPT1 Gene Hs.293077

mRNA Expression by UniProt/SwissProt for CHPT1 Gene

Q8WUD6-CHPT1_HUMAN
Tissue specificity: Highly expressed in testis, colon, small intestine, heart, prostate and spleen. Also detected in kidney, skeletal muscle, pancreas, leukocytes, ovary and thymus. Weakly expressed in the brain, placenta and lung. Overexpressed in cancerous breast epithelial cell lines.
genes like me logo Genes that share expressions with CHPT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CHPT1 Gene

Orthologs for CHPT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHPT1 35
  • 99.34 (n)
  • 98.77 (a)
CHPT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHPT1 35
  • 92.98 (n)
  • 91.88 (a)
CHPT1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHPT1 35
  • 92.94 (n)
  • 90.64 (a)
CHPT1 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chpt1 35
  • 89.39 (n)
  • 89.65 (a)
Chpt1 16
Chpt1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHPT1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHPT1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chpt1 35
  • 89.06 (n)
  • 88.54 (a)
chicken
(Gallus gallus)
Aves CHPT1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHPT1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chpt1 35
  • 66.58 (n)
  • 64.55 (a)
zebrafish
(Danio rerio)
Actinopterygii chpt1 35
  • 66.21 (n)
  • 65.12 (a)
chpt1 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bbc 36
  • 48 (a)
OneToMany
CG6016 37
  • 53 (a)
worm
(Caenorhabditis elegans)
Secernentea cept-1 36
  • 44 (a)
ManyToMany
cept-2 36
  • 38 (a)
ManyToMany
Y49A3A.1 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPT1 36
  • 23 (a)
ManyToMany
EPT1 36
  • 21 (a)
ManyToMany
Species with no ortholog for CHPT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHPT1 Gene

ENSEMBL:
Gene Tree for CHPT1 (if available)
TreeFam:
Gene Tree for CHPT1 (if available)

Paralogs for CHPT1 Gene

Paralogs for CHPT1 Gene

Selected SIMAP similar genes for CHPT1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHPT1: view

Variants for CHPT1 Gene

Sequence variations from dbSNP and Humsavar for CHPT1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11082 -- 101,723,811(-) ATAAA(A/G)TTATT reference, synonymous-codon, nc-transcript-variant
rs222505 -- 101,722,591(+) ctctc(C/G/T)cctgt intron-variant
rs222506 -- 101,722,698(+) AAAAC(A/C)CAAAA intron-variant
rs222507 -- 101,725,095(+) TTAGA(G/T)TTGGA intron-variant
rs222508 -- 101,726,586(+) CCCCC(A/G)TTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHPT1 Gene

Variant ID Type Subtype PubMed ID
nsv832497 CNV Gain 17160897
nsv859 CNV Loss 18451855
esv2566252 CNV Deletion 19546169
nsv435634 CNV Deletion 17901297
esv2746280 CNV Deletion 23290073
esv9053 CNV Loss 19470904
esv2664879 CNV Deletion 23128226
nsv498804 CNV Loss 21111241
nsv826502 CNV Loss 20364138
dgv308n67 CNV Loss 20364138
esv21962 CNV Loss 19812545
nsv514642 CNV Loss 21397061
nsv860 CNV Loss 18451855

Relevant External Links for CHPT1 Gene

HapMap Linkage Disequilibrium report
CHPT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHPT1 Gene

Disorders for CHPT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CHPT1 Gene including...

Search for CHPT1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CHPT1 Gene

(2) Novoseek inferred disease relationships for CHPT1 Gene

Disease -log(P) Hits PubMed IDs
tumors 5.63 1
cancer 0 1

Relevant External Links for CHPT1

Genetic Association Database (GAD)
CHPT1
genes like me logo Genes that share disorders with CHPT1: view

No data available for UniProtKB/Swiss-Prot for CHPT1 Gene

Publications for CHPT1 Gene

  1. Cloning, genomic organization, and characterization of a human cholinephosphotransferase. (PMID: 10893425) Henneberry A.L. … McMaster C.R. (J. Biol. Chem. 2000) 2 3 4 23
  2. Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells. (PMID: 12359261) Ghosh A. … Das S.K. (Biochem. Biophys. Res. Commun. 2002) 3 4 23
  3. Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist. (PMID: 15936720) Akech J. … Das S.K. (Biochem. Biophys. Res. Commun. 2005) 3 23
  4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  5. The major sites of cellular phospholipid synthesis and molecular determinants of fatty acid and lipid head group specificity. (PMID: 12221122) Henneberry A.L. … McMaster C.R. (Mol. Biol. Cell 2002) 4 23

Products for CHPT1 Gene

Sources for CHPT1 Gene

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