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Aliases for CHPF2 Gene

Aliases for CHPF2 Gene

  • Chondroitin Polymerizing Factor 2 2 3 4 5
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 3 4
  • CSGLCA-T 3 4
  • CSGlcAT 3 4
  • ChPF-2 3 4
  • ChSy-3 3 4
  • Chondroitin Sulfate Glucuronyltransferase 3
  • Chondroitin Glucuronyltransferase 4
  • Chondroitin Synthase-3 3
  • Chondroitin Synthase 3 4
  • EC 2.4.1.226 4
  • KIAA1402 4
  • CHSY3 4

External Ids for CHPF2 Gene

Previous GeneCards Identifiers for CHPF2 Gene

  • GC07P150562
  • GC07P150929
  • GC07P144741

Summaries for CHPF2 Gene

GeneCards Summary for CHPF2 Gene

CHPF2 (Chondroitin Polymerizing Factor 2) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring glycosyl groups and N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity. An important paralog of this gene is CHPF.

UniProtKB/Swiss-Prot for CHPF2 Gene

  • Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

Additional gene information for CHPF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHPF2 Gene

Genomics for CHPF2 Gene

GeneHancer (GH) Regulatory Elements for CHPF2 Gene

Promoters and enhancers for CHPF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I151231 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 521 2.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 GC07M151231 CHPF2 ABCF2 NUB1 ENSG00000244151 SMARCD3
GH07I151874 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 18.4 +644.2 644219 4.2 PKNOX1 FOXA2 CLOCK ARNT SIN3A ZNF2 YY1 ZNF213 SP3 REST PRKAG2-AS1 GC07P151876 PRKAG2 NUB1 ENSG00000244151 CHPF2 KMT2C ABCB8
GH07I150364 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 -864.0 -864016 7 MLX ZFP64 DMAP1 YY1 ZNF213 E2F8 ZNF143 NFYC ZC3H11A MEF2D REPIN1 ENSG00000284041 ZNF767P ENSG00000244151 NUB1 ZNF777 ATP6V0E2-AS1 ZNF862 ENSG00000273419 ASIC3
GH07I151517 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.7 +286.8 286838 3.8 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 RHEB NUB1 ENSG00000244151 CHPF2 KMT2C ETF1P2
GH07I151084 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.3 -144.7 -144701 5.9 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 AGAP3 GC07M151084 SLC4A2 FASTK CDK5 ASIC3 SMARCD3 GBX1 ASB10 ENSG00000243433
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CHPF2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CHPF2 Gene

Genomic Locations for CHPF2 Gene
chr7:151,232,489-151,238,827
(GRCh38/hg38)
Size:
6,339 bases
Orientation:
Plus strand
chr7:150,929,575-150,935,908
(GRCh37/hg19)

Genomic View for CHPF2 Gene

Genes around CHPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHPF2 Gene

Proteins for CHPF2 Gene

  • Protein details for CHPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E5-CHPF2_HUMAN
    Recommended name:
    Chondroitin sulfate glucuronyltransferase
    Protein Accession:
    Q9P2E5
    Secondary Accessions:
    • B2DBD8
    • Q6P2I4
    • Q6UXD2

    Protein attributes for CHPF2 Gene

    Size:
    772 amino acids
    Molecular mass:
    85948 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92640.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHPF2 Gene

Post-translational modifications for CHPF2 Gene

  • Glycosylation at posLast=121121 and posLast=342342

Other Protein References for CHPF2 Gene

No data available for DME Specific Peptides for CHPF2 Gene

Domains & Families for CHPF2 Gene

Gene Families for CHPF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for CHPF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHPF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2E5

UniProtKB/Swiss-Prot:

CHPF2_HUMAN :
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CHPF2: view

Function for CHPF2 Gene

Molecular function for CHPF2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.
UniProtKB/Swiss-Prot Function:
Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

Enzyme Numbers (IUBMB) for CHPF2 Gene

Phenotypes From GWAS Catalog for CHPF2 Gene

Gene Ontology (GO) - Molecular Function for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity TAS --
genes like me logo Genes that share ontologies with CHPF2: view
genes like me logo Genes that share phenotypes with CHPF2: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHPF2 Gene

Localization for CHPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHPF2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHPF2 gene
Compartment Confidence
golgi apparatus 5
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with CHPF2: view

Pathways & Interactions for CHPF2 Gene

genes like me logo Genes that share pathways with CHPF2: view

Gene Ontology (GO) - Biological Process for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHPF2: view

No data available for SIGNOR curated interactions for CHPF2 Gene

Drugs & Compounds for CHPF2 Gene

(2) Drugs for CHPF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UDP-alpha-D-glucuronic acid Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CHPF2: view

Transcripts for CHPF2 Gene

Unigene Clusters for CHPF2 Gene

Chondroitin polymerizing factor 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHPF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3: -

Relevant External Links for CHPF2 Gene

GeneLoc Exon Structure for
CHPF2
ECgene alternative splicing isoforms for
CHPF2

Expression for CHPF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHPF2 Gene

Protein differential expression in normal tissues from HIPED for CHPF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.9), Platelet (15.9), and Breast (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHPF2 Gene



Protein tissue co-expression partners for CHPF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHPF2 Gene:

CHPF2

SOURCE GeneReport for Unigene cluster for CHPF2 Gene:

Hs.647084

mRNA Expression by UniProt/SwissProt for CHPF2 Gene:

Q9P2E5-CHPF2_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in placenta, small intestine and pancreas.

Evidence on tissue expression from TISSUES for CHPF2 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CHPF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHPF2 Gene

Orthologs for CHPF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHPF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-671 34
  • 100 (a)
OneToOne
CHPF2 33
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia bta-mir-671 34
  • 96 (a)
OneToOne
CHPF2 33
  • 89.28 (n)
dog
(Canis familiaris)
Mammalia cfa-mir-671 34
  • 96 (a)
OneToOne
CHPF2 33
  • 91.03 (n)
oppossum
(Monodelphis domestica)
Mammalia CHPF2 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHPF2 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chpf2 33 16 34
  • 88.42 (n)
rat
(Rattus norvegicus)
Mammalia Chpf2 33
  • 87.58 (n)
chicken
(Gallus gallus)
Aves CHPF2 33 34
  • 65.55 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii chpf2 33 34
  • 61.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG43313 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-22 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5086 34
  • 38 (a)
OneToMany
Species where no ortholog for CHPF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHPF2 Gene

ENSEMBL:
Gene Tree for CHPF2 (if available)
TreeFam:
Gene Tree for CHPF2 (if available)

Paralogs for CHPF2 Gene

Paralogs for CHPF2 Gene

(1) SIMAP similar genes for CHPF2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHPF2: view

Variants for CHPF2 Gene

Sequence variations from dbSNP and Humsavar for CHPF2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000065234 -- 151,235,909(+) G/A intron_variant
rs1000870549 -- 151,236,756(+) A/G intron_variant
rs1001138882 -- 151,234,454(+) A/T intron_variant
rs1001575878 -- 151,238,408(+) C/T coding_sequence_variant, synonymous_variant
rs1001618165 -- 151,233,226(+) G/A 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CHPF2 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv435860 CNV deletion 17901297
nsv609035 CNV loss 21841781

Variation tolerance for CHPF2 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CHPF2 Gene

Human Gene Mutation Database (HGMD)
CHPF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHPF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHPF2 Gene

Disorders for CHPF2 Gene

Additional Disease Information for CHPF2

No disorders were found for CHPF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHPF2 Gene

Publications for CHPF2 Gene

  1. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. (PMID: 18316376) Izumikawa T … Kitagawa H (The Journal of biological chemistry 2008) 2 3 4 22 58
  2. Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine. (PMID: 12145278) Gotoh M … Narimatsu H (The Journal of biological chemistry 2002) 2 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for CHPF2 Gene

Sources for CHPF2 Gene

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