Free for academic non-profit institutions. Other users need a Commercial license

CHPF2 Gene(Protein Coding)

Chondroitin Polymerizing Factor 2

GCID:
GC07P151232
GIFtS:
48
Genes Participants
UDN Logo

Aliases for CHPF2 Gene

Aliases for CHPF2 Gene

  • Chondroitin Polymerizing Factor 2 2 3 4 5
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 3 4
  • CSGLCA-T 3 4
  • CSGlcAT 3 4
  • ChPF-2 3 4
  • ChSy-3 3 4
  • Chondroitin Sulfate Glucuronyltransferase 3
  • Chondroitin Glucuronyltransferase 4
  • Chondroitin Synthase-3 3
  • Chondroitin Synthase 3 4
  • EC 2.4.1.226 4
  • KIAA1402 4
  • CHSY3 4

External Ids for CHPF2 Gene

Previous GeneCards Identifiers for CHPF2 Gene

  • GC07P150562
  • GC07P150929
  • GC07P144741

Summaries for CHPF2 Gene

GeneCards Summary for CHPF2 Gene

CHPF2 (Chondroitin Polymerizing Factor 2) is a Protein Coding gene. Among its related pathways are Chondroitin sulfate/dermatan sulfate metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity. An important paralog of this gene is CHPF.

UniProtKB/Swiss-Prot for CHPF2 Gene

  • Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHPF2 Gene

Genomics for CHPF2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CHPF2 Gene

Enhancers for CHPF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G151084 1.4 FANTOM5 ENCODE 10.3 -144.7 -144702 5.9 MLX CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 GLIS1 NBN ABCB8 SLC4A2 AGAP3 FASTK CDK5 ASIC3 SMARCD3 GBX1 ASB10 ENSG00000243433
GH07G151303 1.2 Ensembl ENCODE 11 +71.2 71214 0.7 HDGF PKNOX1 ATF1 RB1 FUS AGO1 SIN3A ZNF2 RAD21 TCF12 SMARCD3 ENSG00000243018 GBX1 ASB10 CHPF2 ABCF2 NUB1
GH07G151091 1.1 Ensembl ENCODE 10.3 -141.0 -140989 0.6 HDAC1 TBL1XR1 SIN3A INSM2 ZBTB40 RAD21 ZNF766 ZNF143 CREM HCFC1 AGAP3 SLC4A2 CDK5 ASIC3 GBX1 ASB10 ABCB8 ENSG00000243433 ATG9B ABCF2
GH07G151448 1.1 Ensembl ENCODE 10.2 +216.2 216214 1.4 CTCF RB1 CREB3L1 FUS MAX RBBP5 RAD21 ZNF121 CTBP1 POLR2A ENSG00000241456 RHEB SMARCD3 ENSG00000243018 CHPF2 ABCF2 CRYGN GC07M151465
GH07G151206 0.9 ENCODE 12.1 -25.2 -25236 2.1 HDAC1 PKNOX1 CBX3 TBL1XR1 ARNT TCF12 GATA2 SIRT6 FOS CREM ABCF2 GBX1 CHPF2 SMARCD3 ENSG00000243018 IQCA1L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHPF2 on UCSC Golden Path with GeneCards custom track

Promoters for CHPF2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219807 411 1401 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for CHPF2 Gene

Chromosome:
7
Start:
151,232,489 bp from pter
End:
151,238,827 bp from pter
Size:
6,339 bases
Orientation:
Plus strand

Genomic View for CHPF2 Gene

Genes around CHPF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHPF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHPF2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHPF2 Gene

Proteins for CHPF2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E5-CHPF2_HUMAN
    Recommended name:
    Chondroitin sulfate glucuronyltransferase
    Protein Accession:
    Q9P2E5
    Secondary Accessions:
    • B2DBD8
    • Q6P2I4
    • Q6UXD2

    Protein attributes for CHPF2 Gene

    Size:
    772 amino acids
    Molecular mass:
    85948 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92640.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHPF2 Gene

Protein Expression for CHPF2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CHPF2 Gene

  • Glycosylation at Asn121 and Asn342
  • Modification sites at PhosphoSitePlus

Other Protein References for CHPF2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHPF2 Gene

Domains & Families for CHPF2 Gene

Gene Families for CHPF2 Gene

HGNC:

Protein Domains for CHPF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHPF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2E5

UniProtKB/Swiss-Prot:

CHPF2_HUMAN :
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CHPF2: view

Function for CHPF2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CHPF2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.
UniProtKB/Swiss-Prot Function:
Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

Enzyme Numbers (IUBMB) for CHPF2 Gene

Gene Ontology (GO) - Molecular Function for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity TAS --
genes like me logo Genes that share ontologies with CHPF2: view
genes like me logo Genes that share phenotypes with CHPF2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHPF2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHPF2 Gene

Localization for CHPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHPF2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHPF2 gene
Compartment Confidence
golgi apparatus 5
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with CHPF2: view

Pathways & Interactions for CHPF2 Gene

genes like me logo Genes that share pathways with CHPF2: view

Gene Ontology (GO) - Biological Process for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHPF2: view

No data available for SIGNOR curated interactions for CHPF2 Gene

Drugs & Compounds for CHPF2 Gene

Products:

  1. Drug

(2) Drugs for CHPF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
UDP-alpha-D-glucuronic acid Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with CHPF2: view

Transcripts for CHPF2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CHPF2 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(198) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHPF2 Gene

Chondroitin polymerizing factor 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHPF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3: -

Relevant External Links for CHPF2 Gene

GeneLoc Exon Structure for
CHPF2
ECgene alternative splicing isoforms for
CHPF2

Expression for CHPF2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHPF2 Gene

mRNA expression in normal human tissues for CHPF2 Gene
mRNA expression by BioGPS for CHPF2 GenemRNA expression by GTEx for CHPF2 Gene

Protein differential expression in normal tissues from HIPED for CHPF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.9), Platelet (15.9), and Breast (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHPF2 Gene



Protein tissue co-expression partners for CHPF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHPF2 Gene:

CHPF2

SOURCE GeneReport for Unigene cluster for CHPF2 Gene:

Hs.647084

mRNA Expression by UniProt/SwissProt for CHPF2 Gene:

Q9P2E5-CHPF2_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in placenta, small intestine and pancreas.

Evidence on tissue expression from TISSUES for CHPF2 Gene

  • Nervous system(4.5)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with CHPF2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHPF2 Gene

Orthologs for CHPF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHPF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-671 35
  • 100 (a)
 OneToOne
CHPF2 34
  • 99.69 (n)
cow
(Bos Taurus)
 Mammalia bta-mir-671 35
  • 96 (a)
 OneToOne
CHPF2 34
  • 89.28 (n)
dog
(Canis familiaris)
 Mammalia cfa-mir-671 35
  • 96 (a)
 OneToOne
CHPF2 34
  • 91.03 (n)
oppossum
(Monodelphis domestica)
 Mammalia CHPF2 35
  • 92 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CHPF2 35
  • 91 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Chpf2 34 16 35
  • 88.42 (n)
rat
(Rattus norvegicus)
 Mammalia Chpf2 34
  • 87.58 (n)
chicken
(Gallus gallus)
 Aves CHPF2 34 35
  • 65.55 (n)
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 55 (a)
 OneToMany
zebrafish
(Danio rerio)
 Actinopterygii chpf2 34 35
  • 61.74 (n)
fruit fly
(Drosophila melanogaster)
 Insecta CG43313 35
  • 27 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea mig-22 35
  • 24 (a)
 OneToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.5086 35
  • 38 (a)
 OneToMany
Species where no ortholog for CHPF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHPF2 Gene

ENSEMBL:
Gene Tree for CHPF2 (if available)
TreeFam:
Gene Tree for CHPF2 (if available)

Paralogs for CHPF2 Gene

Paralogs for CHPF2 Gene

(1) SIMAP similar genes for CHPF2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHPF2: view

Variants for CHPF2 Gene

Sequence variations from dbSNP and Humsavar for CHPF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000065234 -- 151,235,909(+) TGTGG(A/G)CATGT intron-variant
rs1000870549 -- 151,236,756(+) CAACT(A/G)CAGGG intron-variant, upstream-variant-2KB
rs1001138882 -- 151,234,454(+) CTCAC(A/T)TTCAT intron-variant
rs1001575878 -- 151,238,408(+) GCGGC(C/T)CGAGC upstream-variant-2KB, reference, synonymous-codon
rs1001618165 -- 151,233,226(+) GTTCC(A/G)AGGAG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CHPF2 Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv435860 CNV deletion 17901297
nsv609035 CNV loss 21841781

Variation tolerance for CHPF2 Gene

Residual Variation Intolerance Score: 91.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHPF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHPF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHPF2 Gene

Disorders for CHPF2 Gene

Relevant External Links for CHPF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHPF2

No disorders were found for CHPF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHPF2 Gene

Publications for CHPF2 Gene

  1. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. (PMID: 18316376) Izumikawa T. … Kitagawa H. (J. Biol. Chem. 2008) 2 3 4 22 64
  2. Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N- acetylgalactosamine. (PMID: 12145278) Gotoh M. … Narimatsu H. (J. Biol. Chem. 2002) 2 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for CHPF2 Gene

Sources for CHPF2 Gene

Content
Loading form....