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Aliases for CHPF2 Gene

Aliases for CHPF2 Gene

  • Chondroitin Polymerizing Factor 2 2 3 4
  • CSGlcAT 3 4 6
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 3 4
  • CSGLCA-T 3 4
  • KIAA1402 4 6
  • ChPF-2 3 4
  • ChSy-3 3 4
  • Chondroitin Sulfate Glucuronyltransferase 3
  • Chondroitin Glucuronyltransferase 4
  • Chondroitin Synthase-3 3
  • Chondroitin Synthase 3 4
  • EC 4
  • CHSY3 4

External Ids for CHPF2 Gene

Previous GeneCards Identifiers for CHPF2 Gene

  • GC07P150562
  • GC07P150929
  • GC07P144741

Summaries for CHPF2 Gene

GeneCards Summary for CHPF2 Gene

CHPF2 (Chondroitin Polymerizing Factor 2) is a Protein Coding gene. Diseases associated with CHPF2 include mucopolysaccharidoses. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity. An important paralog of this gene is B4GALNT4.

UniProtKB/Swiss-Prot for CHPF2 Gene

  • Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHPF2 Gene

Genomics for CHPF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHPF2 Gene

151,232,489 bp from pter
151,238,827 bp from pter
6,339 bases
Plus strand

Genomic View for CHPF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHPF2 Gene

No data available for Regulatory Elements for CHPF2 Gene

Proteins for CHPF2 Gene

  • Protein details for CHPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chondroitin sulfate glucuronyltransferase
    Protein Accession:
    Secondary Accessions:
    • B2DBD8
    • Q6P2I4
    • Q6UXD2

    Protein attributes for CHPF2 Gene

    772 amino acids
    Molecular mass:
    85948 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA92640.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHPF2 Gene


neXtProt entry for CHPF2 Gene

Proteomics data for CHPF2 Gene at MOPED

Post-translational modifications for CHPF2 Gene

  • Glycosylation at Asn121 and Asn342
  • Modification sites at PhosphoSitePlus

Other Protein References for CHPF2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHPF2 Gene

Domains for CHPF2 Gene

Gene Families for CHPF2 Gene

  • B3GT :Beta 3-glycosyltransferases
  • B4GT :Beta 4-glycosyltransferases

Protein Domains for CHPF2 Gene


Suggested Antigen Peptide Sequences for CHPF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9P2E5
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CHPF2: view

Function for CHPF2 Gene

Molecular function for CHPF2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
UniProtKB/Swiss-Prot Function:
Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

Enzyme Numbers (IUBMB) for CHPF2 Gene

Gene Ontology (GO) - Molecular Function for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA --
genes like me logo Genes that share ontologies with CHPF2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHPF2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHPF2 Gene

Localization for CHPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHPF2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for CHPF2 Gene COMPARTMENTS Subcellular localization image for CHPF2 gene
Compartment Confidence
golgi apparatus 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with CHPF2: view

Pathways for CHPF2 Gene

genes like me logo Genes that share pathways with CHPF2: view

Interacting Proteins for CHPF2 Gene

Gene Ontology (GO) - Biological Process for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0008152 metabolic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHPF2: view

Compounds for CHPF2 Gene

(2) HMDB Compounds for CHPF2 Gene

Compound Synonyms Cas Number PubMed IDs
Uridine 5'-diphosphate
  • 5'-UDP
Uridine diphosphate glucuronic acid
  • UDP glucuronate
genes like me logo Genes that share compounds with CHPF2: view

Transcripts for CHPF2 Gene

Unigene Clusters for CHPF2 Gene

Chondroitin polymerizing factor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHPF2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHPF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP3: -

Relevant External Links for CHPF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHPF2 Gene

mRNA expression in normal human tissues for CHPF2 Gene

Protein differential expression in normal tissues for CHPF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.9), Platelet (15.9), and Breast (8.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHPF2 Gene

SOURCE GeneReport for Unigene cluster for CHPF2 Gene Hs.647084

mRNA Expression by UniProt/SwissProt for CHPF2 Gene

Tissue specificity: Ubiquitous. Highly expressed in placenta, small intestine and pancreas.
genes like me logo Genes that share expressions with CHPF2: view

Expression partners for CHPF2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHPF2 Gene

Orthologs for CHPF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHPF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHPF2 35
  • 89.28 (n)
  • 95.81 (a)
bta-mir-671 36
  • 96 (a)
(Canis familiaris)
Mammalia CHPF2 35
  • 91.03 (n)
  • 96.64 (a)
cfa-mir-671 36
  • 96 (a)
(Mus musculus)
Mammalia Chpf2 35
  • 88.42 (n)
  • 93.68 (a)
Chpf2 16
Chpf2 36
  • 96 (a)
(Pan troglodytes)
Mammalia CHPF2 35
  • 99.69 (n)
  • 99.74 (a)
ptr-mir-671 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Chpf2 35
  • 87.58 (n)
  • 92.78 (a)
(Monodelphis domestica)
Mammalia CHPF2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CHPF2 36
  • 91 (a)
(Gallus gallus)
Aves CHPF2 35
  • 65.55 (n)
  • 67.91 (a)
CHPF2 36
  • 68 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
(Danio rerio)
Actinopterygii chpf2 35
  • 61.74 (n)
  • 59.39 (a)
chpf2 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43313 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea mig-22 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5086 36
  • 38 (a)
Species with no ortholog for CHPF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHPF2 Gene

Gene Tree for CHPF2 (if available)
Gene Tree for CHPF2 (if available)

Paralogs for CHPF2 Gene

Paralogs for CHPF2 Gene

Selected SIMAP similar genes for CHPF2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHPF2: view

Variants for CHPF2 Gene

Sequence variations from dbSNP and Humsavar for CHPF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs921987 -- 151,236,197(+) TAGCC(A/C/G)AGAGT intron-variant
rs2125155 -- 151,234,408(-) AAGAA(A/C)CCATG intron-variant
rs2252694 -- 151,233,879(+) GGCCT(A/C/T)GCTCT intron-variant, utr-variant-5-prime
rs2487155 -- 151,236,172(-) CTTAC(A/G)GGCTA intron-variant
rs2608292 -- 151,234,649(-) CTGGG(C/T)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHPF2 Gene

Variant ID Type Subtype PubMed ID
nsv889476 CNV Loss 21882294
nsv889487 CNV Loss 21882294
nsv435860 CNV Deletion 17901297
nsv889488 CNV Loss 21882294

Relevant External Links for CHPF2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHPF2 Gene

Disorders for CHPF2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CHPF2 Gene in MalaCards »

(1) Diseases for CHPF2 Gene including...

genes like me logo Genes that share disorders with CHPF2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CHPF2 Gene

Publications for CHPF2 Gene

  1. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. (PMID: 18316376) Izumikawa T. … Kitagawa H. (J. Biol. Chem. 2008) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  3. Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N- acetylgalactosamine. (PMID: 12145278) Gotoh M. … Narimatsu H. (J. Biol. Chem. 2002) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for CHPF2 Gene

Sources for CHPF2 Gene

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