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Aliases for CHPF2 Gene

Aliases for CHPF2 Gene

  • Chondroitin Polymerizing Factor 2 2 3 4
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase 3 4
  • CSGLCA-T 3 4
  • CSGlcAT 3 4
  • ChPF-2 3 4
  • ChSy-3 3 4
  • Chondroitin Glucuronyltransferase 4
  • Chondroitin Synthase-3 3
  • Chondroitin Synthase 3 4
  • EC 2.4.1.226 4
  • KIAA1402 4
  • CHSY3 4

External Ids for CHPF2 Gene

Previous GeneCards Identifiers for CHPF2 Gene

  • GC07P150562
  • GC07P150929
  • GC07P144741

Summaries for CHPF2 Gene

GeneCards Summary for CHPF2 Gene

CHPF2 (Chondroitin Polymerizing Factor 2) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity. An important paralog of this gene is B4GALNT4.

UniProtKB/Swiss-Prot for CHPF2 Gene

  • Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHPF2 Gene

Genomics for CHPF2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHPF2 Gene

Chromosome:
7
Start:
151,232,489 bp from pter
End:
151,238,827 bp from pter
Size:
6,339 bases
Orientation:
Plus strand

Genomic View for CHPF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHPF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHPF2 Gene

No data available for Regulatory Elements for CHPF2 Gene

Proteins for CHPF2 Gene

  • Protein details for CHPF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2E5-CHPF2_HUMAN
    Recommended name:
    Chondroitin sulfate glucuronyltransferase
    Protein Accession:
    Q9P2E5
    Secondary Accessions:
    • B2DBD8
    • Q6P2I4
    • Q6UXD2

    Protein attributes for CHPF2 Gene

    Size:
    772 amino acids
    Molecular mass:
    85948 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92640.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHPF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHPF2 Gene

Proteomics data for CHPF2 Gene at MOPED

Post-translational modifications for CHPF2 Gene

  • Glycosylation at Asn 121 and Asn 342
  • Modification sites at PhosphoSitePlus

Other Protein References for CHPF2 Gene

No data available for DME Specific Peptides for CHPF2 Gene

Domains & Families for CHPF2 Gene

Gene Families for CHPF2 Gene

Protein Domains for CHPF2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHPF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9P2E5

UniProtKB/Swiss-Prot:

CHPF2_HUMAN :
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CHPF2: view

Function for CHPF2 Gene

Molecular function for CHPF2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
UniProtKB/Swiss-Prot Function:
Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity.

Enzyme Numbers (IUBMB) for CHPF2 Gene

Gene Ontology (GO) - Molecular Function for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008376 acetylgalactosaminyltransferase activity IEA --
GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA --
genes like me logo Genes that share ontologies with CHPF2: view

Phenotypes for CHPF2 Gene

genes like me logo Genes that share phenotypes with CHPF2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHPF2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CHPF2 Gene

Localization for CHPF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHPF2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHPF2 Gene COMPARTMENTS Subcellular localization image for CHPF2 gene
Compartment Confidence
golgi apparatus 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with CHPF2: view

Pathways & Interactions for CHPF2 Gene

genes like me logo Genes that share pathways with CHPF2: view

Interacting Proteins for CHPF2 Gene

Gene Ontology (GO) - Biological Process for CHPF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0008152 metabolic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHPF2: view

No data available for SIGNOR curated interactions for CHPF2 Gene

Drugs & Compounds for CHPF2 Gene

(1) Drugs for CHPF2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine 5'-diphosphate Experimental Pharma 0

(1) Additional Compounds for CHPF2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Uridine diphosphate glucuronic acid
  • a-D-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • a-D-Glucopyranuronic acid ester with uridine 5'-pyrophosphate
  • alpha-D-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
  • alpha-delta-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • alpha-delta-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
2616-64-0
genes like me logo Genes that share compounds with CHPF2: view

Transcripts for CHPF2 Gene

Unigene Clusters for CHPF2 Gene

Chondroitin polymerizing factor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHPF2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHPF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1:
SP2:
SP3: -

Relevant External Links for CHPF2 Gene

GeneLoc Exon Structure for
CHPF2
ECgene alternative splicing isoforms for
CHPF2

Expression for CHPF2 Gene

mRNA expression in normal human tissues for CHPF2 Gene

Protein differential expression in normal tissues from HIPED for CHPF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.9), Platelet (15.9), and Breast (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHPF2 Gene



SOURCE GeneReport for Unigene cluster for CHPF2 Gene Hs.647084

mRNA Expression by UniProt/SwissProt for CHPF2 Gene

Q9P2E5-CHPF2_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in placenta, small intestine and pancreas.
genes like me logo Genes that share expression patterns with CHPF2: view

Protein tissue co-expression partners for CHPF2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHPF2 Gene

Orthologs for CHPF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHPF2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHPF2 35
  • 89.28 (n)
  • 95.81 (a)
bta-mir-671 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHPF2 35
  • 91.03 (n)
  • 96.64 (a)
cfa-mir-671 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chpf2 35
  • 88.42 (n)
  • 93.68 (a)
Chpf2 16
Chpf2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHPF2 35
  • 99.69 (n)
  • 99.74 (a)
ptr-mir-671 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chpf2 35
  • 87.58 (n)
  • 92.78 (a)
oppossum
(Monodelphis domestica)
Mammalia CHPF2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHPF2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHPF2 35
  • 65.55 (n)
  • 67.91 (a)
CHPF2 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 55 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii chpf2 35
  • 61.74 (n)
  • 59.39 (a)
chpf2 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43313 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-22 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5086 36
  • 38 (a)
OneToMany
Species with no ortholog for CHPF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHPF2 Gene

ENSEMBL:
Gene Tree for CHPF2 (if available)
TreeFam:
Gene Tree for CHPF2 (if available)

Paralogs for CHPF2 Gene

Paralogs for CHPF2 Gene

(1) SIMAP similar genes for CHPF2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHPF2: view

Variants for CHPF2 Gene

Sequence variations from dbSNP and Humsavar for CHPF2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs921987 -- 151,236,197(+) TAGCC(A/C/G)AGAGT intron-variant
rs2125155 -- 151,234,408(-) AAGAA(A/C)CCATG intron-variant
rs2252694 -- 151,233,879(+) GGCCT(A/C/T)GCTCT intron-variant, utr-variant-5-prime
rs2487155 -- 151,236,172(-) CTTAC(A/G)GGCTA intron-variant
rs2608292 -- 151,234,649(-) CTGGG(C/T)GTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHPF2 Gene

Variant ID Type Subtype PubMed ID
nsv889476 CNV Loss 21882294
nsv889487 CNV Loss 21882294
nsv435860 CNV Deletion 17901297
nsv889488 CNV Loss 21882294

Variation tolerance for CHPF2 Gene

Residual Variation Intolerance Score: 91.45% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHPF2 Gene

HapMap Linkage Disequilibrium report
CHPF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHPF2 Gene

Disorders for CHPF2 Gene

Relevant External Links for CHPF2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHPF2
genes like me logo Genes that share disorders with CHPF2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHPF2 Gene

Publications for CHPF2 Gene

  1. Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family members. (PMID: 18316376) Izumikawa T. … Kitagawa H. (J. Biol. Chem. 2008) 2 23 67
  2. Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities. (PMID: 12761225) Yada T. … Kimata K. (J. Biol. Chem. 2003) 23 67
  3. Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N- acetylgalactosamine. (PMID: 12145278) Gotoh M. … Narimatsu H. (J. Biol. Chem. 2002) 2 67
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for CHPF2 Gene

Sources for CHPF2 Gene

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