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Aliases for CHPF Gene

Aliases for CHPF Gene

  • Chondroitin Polymerizing Factor 2 3
  • CSS2 3 4 6
  • Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase II 3 4
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase II 3 4
  • Chondroitin Glucuronyltransferase 2 3 4
  • N-Acetylgalactosaminyltransferase 2 3 4
  • Chondroitin-Polymerizing Factor 3 4
  • Chondroitin Sulfate Synthase 2 2 3
  • EC 4
  • EC 4
  • CHSY2 3
  • ChPF 4

External Ids for CHPF Gene

Previous GeneCards Identifiers for CHPF Gene

  • GC02M220367
  • GC02M220606
  • GC02M220229
  • GC02M220111
  • GC02M212256

Summaries for CHPF Gene

GeneCards Summary for CHPF Gene

CHPF (Chondroitin Polymerizing Factor) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity and N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity. An important paralog of this gene is B4GALNT4.

UniProtKB/Swiss-Prot for CHPF Gene

  • Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress.

Gene Wiki entry for CHPF Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHPF Gene

Genomics for CHPF Gene

Regulatory Elements for CHPF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHPF Gene

219,538,947 bp from pter
219,543,787 bp from pter
4,841 bases
Minus strand

Genomic View for CHPF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHPF Gene

Proteins for CHPF Gene

  • Protein details for CHPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chondroitin sulfate synthase 2
    Protein Accession:
    Secondary Accessions:
    • B4DXU0
    • Q6UXD6
    • Q7L4G1
    • Q9H0F8
    • Q9H618

    Protein attributes for CHPF Gene

    775 amino acids
    Molecular mass:
    85467 Da
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Highest activities are measured with Mn(2+). Can also utilize Co(2+).;
    Quaternary structure:
    • Binds CHSY1. Isoform 1, isoform 2 and isoform 3 interact with PARK2

    Alternative splice isoforms for CHPF Gene


neXtProt entry for CHPF Gene

Proteomics data for CHPF Gene at MOPED

Post-translational modifications for CHPF Gene

  • Glycosylation at Asn138 and Asn361
  • Modification sites at PhosphoSitePlus

Other Protein References for CHPF Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHPF Gene

Domains for CHPF Gene

Gene Families for CHPF Gene

  • B3GT :Beta 3-glycosyltransferases
  • B4GT :Beta 4-glycosyltransferases

Protein Domains for CHPF Gene


Suggested Antigen Peptide Sequences for CHPF Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8IZ52
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CHPF: view

Function for CHPF Gene

Molecular function for CHPF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan
UniProtKB/Swiss-Prot Function:
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress.

Enzyme Numbers (IUBMB) for CHPF Gene

Gene Ontology (GO) - Molecular Function for CHPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22082830
GO:0008376 acetylgalactosaminyltransferase activity --
GO:0016757 transferase activity, transferring glycosyl groups --
GO:0046872 metal ion binding IEA --
GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA --
genes like me logo Genes that share ontologies with CHPF: view

Phenotypes for CHPF Gene

genes like me logo Genes that share phenotypes with CHPF: view

Animal Models for CHPF Gene

MGI Knock Outs for CHPF:

Animal Model Products

miRNA for CHPF Gene

miRTarBase miRNAs that target CHPF

No data available for Transcription Factor Targeting and HOMER Transcription for CHPF Gene

Localization for CHPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHPF Gene

Isoform 1: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cytoplasm, cytosol.
Isoform 3: Cytoplasm, cytosol. Mitochondrion.
Isoform 2: Mitochondrion matrix.

Subcellular locations from

Jensen Localization Image for CHPF Gene COMPARTMENTS Subcellular localization image for CHPF gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IEA --
GO:0005829 cytosol IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CHPF: view

Pathways for CHPF Gene

genes like me logo Genes that share pathways with CHPF: view

Gene Ontology (GO) - Biological Process for CHPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0008152 metabolic process --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030204 chondroitin sulfate metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
genes like me logo Genes that share ontologies with CHPF: view

Compounds for CHPF Gene

(6) HMDB Compounds for CHPF Gene

Compound Synonyms Cas Number PubMed IDs
  • Co
  • beta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • manganese
Uridine 5'-diphosphate
  • 5'-UDP
Uridine diphosphate glucuronic acid
  • UDP glucuronate

(2) Novoseek inferred chemical compound relationships for CHPF Gene

Compound -log(P) Hits PubMed IDs
chondroitin 88.2 8
chondroitin sulfate 76.9 2
genes like me logo Genes that share compounds with CHPF: view

Transcripts for CHPF Gene

Unigene Clusters for CHPF Gene

Chondroitin polymerizing factor:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHPF

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHPF Gene

No ASD Table

Relevant External Links for CHPF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHPF Gene

mRNA expression in normal human tissues for CHPF Gene

Protein differential expression in normal tissues for CHPF Gene

This gene is overexpressed in Breast (50.0) and Testis (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHPF Gene

SOURCE GeneReport for Unigene cluster for CHPF Gene Hs.516711

mRNA Expression by UniProt/SwissProt for CHPF Gene

Tissue specificity: Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells.
genes like me logo Genes that share expressions with CHPF: view

Expression partners for CHPF Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHPF Gene

Orthologs for CHPF Gene

This gene was present in the common ancestor of animals.

Orthologs for CHPF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHPF 35
  • 90.19 (n)
  • 95.87 (a)
  • 96 (a)
(Canis familiaris)
Mammalia CHPF 35
  • 89.39 (n)
  • 95.86 (a)
(Mus musculus)
Mammalia Chpf 35
  • 87.04 (n)
  • 94.44 (a)
Chpf 16
Chpf 36
  • 94 (a)
(Pan troglodytes)
Mammalia CHPF 35
  • 99.1 (n)
  • 99.1 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Chpf 35
  • 86.88 (n)
  • 94.03 (a)
(Monodelphis domestica)
Mammalia CHPF 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 14 (a)
(Gallus gallus)
Aves CHPF 35
  • 70.76 (n)
  • 63.57 (a)
-- 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chpf 35
  • 65.85 (n)
  • 61.07 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6761 35
(Danio rerio)
Actinopterygii chpfa 35
  • 58.65 (n)
  • 54.51 (a)
Dr.13607 35
chpf2 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001050 35
  • 40.79 (n)
  • 30.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43313 35
  • 46.17 (n)
  • 32.01 (a)
CG43313 36
  • 27 (a)
(Caenorhabditis elegans)
Secernentea mig-22 35
  • 40.43 (n)
  • 31.13 (a)
mig-22 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5086 36
  • 36 (a)
Species with no ortholog for CHPF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHPF Gene

Gene Tree for CHPF (if available)
Gene Tree for CHPF (if available)

Paralogs for CHPF Gene

Selected SIMAP similar genes for CHPF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHPF: view

Variants for CHPF Gene

Sequence variations from dbSNP and Humsavar for CHPF Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1043832 -- 219,540,004(-) GCCCA(C/G/T)GTGGC reference, missense, synonymous-codon
rs1043833 -- 219,539,926(-) CCACT(A/G)CGCCT synonymous-codon, reference
rs3180308 -- 219,541,460(-) CCTGG(A/G)CTTCA intron-variant
rs6436154 -- 219,540,508(+) AAAGC(A/G)TGCTG reference, synonymous-codon
rs6722853 -- 219,539,997(+) CAGCT(A/C)TGCCA reference, stop-gained

Structural Variations from Database of Genomic Variants (DGV) for CHPF Gene

Variant ID Type Subtype PubMed ID
nsv520958 CNV Loss 19592680
dgv4438n71 CNV Loss 21882294
nsv875875 CNV Loss 21882294
nsv875876 CNV Loss 21882294
nsv834545 CNV Loss 17160897
nsv508887 CNV Insertion 20534489
nsv482056 CNV Gain 20164927

Relevant External Links for CHPF Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHPF Gene

Disorders for CHPF Gene

No disorders were found for CHPF Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CHPF Gene

Publications for CHPF Gene

  1. Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. (PMID: 12716890) Kitagawa H. … Sugahara K. (J. Biol. Chem. 2003) 2 3 4 23
  2. Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities. (PMID: 12761225) Yada T. … Kimata K. (J. Biol. Chem. 2003) 3 4 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  4. Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential. (PMID: 22082830) Kuroda Y. … Mitsui T. (Hum. Mol. Genet. 2012) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for CHPF Gene

Sources for CHPF Gene

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