Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CHPF Gene

protein-coding   GIFtS: 56
GCID: GC02M220367

Chondroitin Polymerizing Factor

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chondroitin Polymerizing Factor1 2     N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase II2 3
CSS22 3 5     N-Acetylgalactosaminyltransferase 22 3
Chondroitin Sulfate Synthase 21 2     CHSY22
Chondroitin Glucuronyltransferase 22 3     ChPF3
Chondroitin-Polymerizing Factor2 3     EC 2.4.1.1753
Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan
4-Beta-N-Acetylgalactosaminyltransferase II2 3
     EC 2.4.1.2263

External Ids:    HGNC: 242911   Entrez Gene: 795862   Ensembl: ENSG000001239897   OMIM: 6104055   UniProtKB: Q8IZ523   

Export aliases for CHPF gene to outside databases

Previous GC identifers: GC02M220606 GC02M220229 GC02M220111 GC02M212256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CHPF Gene:
CHPF (chondroitin polymerizing factor) is a protein-coding gene. GO annotations related to this gene include glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity and N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity. An important paralog of this gene is CSGALNACT1.

UniProtKB/Swiss-Prot: CHSS2_HUMAN, Q8IZ52
Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers
glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end
of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In
collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress

Gene Wiki entry for CHPF Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHPF gene promoter:
         GR   Spz1   RFX1   Pax-5   GR-beta   GATA-1   HSF2   PPAR-gamma2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHPF promoter sequence
   Search Chromatin IP Primers for CHPF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHPF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

CHPF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHPF gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M220367:  view genomic region     (about GC identifiers)

Start:
220,403,669 bp from pter      End:
220,408,509 bp from pter
Size:
4,841 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CHSS2_HUMAN, Q8IZ52 (See protein sequence)
Recommended Name: Chondroitin sulfate synthase 2  
Size: 775 amino acids; 85467 Da
Cofactor: Mn(2+). Highest activities are measured with manganese. Can also utilize cobalt
Subunit: Binds CHSY1. Isoform 1, isoform 2 and isoform 3 interact with PARK2
Secondary accessions: B4DXU0 Q6UXD6 Q7L4G1 Q9H0F8 Q9H618
Alternative splicing: 3 isoforms:  Q8IZ52-1   Q8IZ52-2   Q8IZ52-4   

Explore the universe of human proteins at neXtProt for CHPF: NX_Q8IZ52

Explore proteomics data for CHPF at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn138, Asn361
  • Modification sites at PhosphoSitePlus

  • See CHPF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001182660.1  NP_078812.2  

    ENSEMBL proteins: 
     ENSP00000243776   ENSP00000362998   ENSP00000445571  
    Reactome Protein details: Q8IZ52

    CHPF Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CHPF
    OriGene Protein Over-expression Lysate for CHPF
    OriGene MassSpec for CHPF
    OriGene Custom Protein Services for CHPF
    GenScript Custom Purified and Recombinant Proteins Services for CHPF
    Novus Biologicals CHPF Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHPF

     
    Search eBioscience for Proteins for CHPF 

    CHPF Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CHPF
    OriGene Custom Antibody Services for CHPF
    Novus Biologicals CHPF Antibody
    Abcam antibodies for CHPF
    Cloud-Clone Corp. Antibodies for CHPF
    ThermoFisher Antibody for CHPF
    LSBio Antibodies in human, mouse, rat for CHPF

    CHPF Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHPF
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHPF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHPF
    Cloud-Clone Corp. CLIAs for CHPF
    Search eBioscience for ELISAs for CHPF 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    B3GT: Beta 3-glycosyltransferases
    B4GT: Beta 4-glycosyltransferases

    1 InterPro protein domain:
     IPR008428 Chond_GalNAc

    Graphical View of Domain Structure for InterPro Entry Q8IZ52

    ProtoNet protein and cluster: Q8IZ52

    UniProtKB/Swiss-Prot: CHSS2_HUMAN, Q8IZ52
    Similarity: Belongs to the chondroitin N-acetylgalactosaminyltransferase family


    Find genes that share domains with CHPF           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHSS2_HUMAN, Q8IZ52
    Function: Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers
    glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end
    of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In
    collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress
    Catalytic activity: UDP-N-acetyl-alpha-D-galactosamine +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP +
    N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan
    Catalytic activity: UDP-alpha-D-glucuronate +
    N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP +
    beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan

         Enzyme Numbers (IUBMB): EC 2.4.1.2261 EC 2.4.1.1751

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0046872metal ion binding IEA--
    GO:0047238glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA--
    GO:0050510N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IEA--
         
    Find genes that share ontologies with CHPF           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Chpf):
     limbs/digits/tail  normal  skeleton 

    Find genes that share phenotypes with CHPF           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CHPF: Chpftm1.2Hwat Chpftm1Lex

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHPF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHPF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHPF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHPF

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHPF:
    hsa-mir-15b-5p (MIRT046494), hsa-mir-26b-5p (MIRT029890), hsa-mir-375 (MIRT019908)

    Block miRNA regulation of human, mouse, rat CHPF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHPF (see all 9):
    hsa-miR-217 hsa-miR-4291 hsa-miR-485-5p hsa-miR-3194-5p hsa-miR-922 hsa-miR-503 hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCHPF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHPF
    Predesigned siRNA for gene silencing in human, mouse, rat CHPF

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHPF

    Clone
    Products:
         
    OriGene clones in human, mouse for CHPF (see all 11)
    OriGene ORF clones in mouse, rat for CHPF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHPF (NM_019015)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHPF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHPF

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHPF
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHPF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHPF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CHSS2_HUMAN, Q8IZ52: Isoform 1: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein
    (Probable). Cytoplasm, cytosol
    CHSS2_HUMAN, Q8IZ52: Isoform 3: Cytoplasm, cytosol. Mitochondrion
    CHSS2_HUMAN, Q8IZ52: Isoform 2: Mitochondrion matrix (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum2
    cytoskeleton1
    cytosol1
    extracellular1
    lysosome1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005759mitochondrial matrix IEA--
    GO:0005829cytosol IEA--
    GO:0016021integral component of membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with CHPF           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CHPF About    
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIID - Sanfilippo syndrome D0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS I - Hurler syndrome0.45
    MPS IV - Morquio syndrome A0.45
    MPS IV - Morquio syndrome B0.45
    MPS IIIA - Sanfilippo syndrome A0.45
    MPS VII - Sly syndrome0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate0.00
    Chondroitin sulfate biosynthesis0.41
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4dermatan sulfate biosynthesis
    dermatan sulfate biosynthesis
    chondroitin and dermatan biosynthesis0.00
    5Disease
    Disease


    Find genes that share SuperPaths with CHPF           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for CHPF
        chondroitin and dermatan biosynthesis
    chondroitin sulfate biosynthesis (late stages)
    chondroitin sulfate biosynthesis
    dermatan sulfate biosynthesis

    1 Reactome Pathway for CHPF
        Chondroitin sulfate biosynthesis


    2 Kegg Pathways  (Kegg details for CHPF):
        Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
    Metabolic pathways

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHPF
    Interactions:

        GeneGlobe Interaction Network for CHPF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHPF (Q8IZ521, 2, 3 ENSP000002437764) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKILP127572, 3MINT-61685 I2D: score=3 
    SMAD9O151982, 3MINT-62112 I2D: score=3 
    PIN1Q135262, 3, ENSP000002479704MINT-64894 I2D: score=4 STRING: ENSP00000247970
    EXOSC6Q5RKV63, ENSP000003985974I2D: score=2 STRING: ENSP00000398597
    EXOSC10Q017803, ENSP000003661354I2D: score=3 STRING: ENSP00000366135
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0030204chondroitin sulfate metabolic process TAS--
    GO:0030206chondroitin sulfate biosynthetic process TAS--
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with CHPF           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHPF (CHSS2)

    6 HMDB Compounds for CHPF    About this table
    CompoundSynonyms CAS #PubMed Ids
    CobaltCo (see all 6)7440-48-4--
    Lactosaminebeta-D-galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose (see all 8)13000-25-4--
    Manganesemanganese 7439-96-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucuronic acidUDP glucuronate (see all 41)2616-64-0--
    Uridine diphosphate-N-acetylgalactosamineUDP-N-acetyl-D-galactosamine (see all 17)7277-98-7--

    2 Novoseek inferred chemical compound relationships for CHPF gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondroitin 88.2 19 18316376 (3), 17253960 (2), 12716890 (2), 15485872 (1)
    chondroitin sulfate 76.9 4 18316376 (2)



    Find genes that share compounds with CHPF           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CHPF gene (2 alternative transcripts): 
    NM_001195731.1  NM_024536.5  

    Unigene Cluster for CHPF:

    Chondroitin polymerizing factor
    Hs.516711  [show with all ESTs]
    Unigene Representative Sequence: AB095813
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000243776(uc010zlh.2 uc002vmc.4) ENST00000373891 ENST00000535926

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHPF using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHPF (see all 9):
    hsa-miR-217 hsa-miR-4291 hsa-miR-485-5p hsa-miR-3194-5p hsa-miR-922 hsa-miR-503 hsa-miR-214 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidCHPF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHPF
    Predesigned siRNA for gene silencing in human, mouse, rat CHPF
    Clone
    Products:
         
    OriGene clones in human, mouse for CHPF (see all 11)
    OriGene ORF clones in mouse, rat for CHPF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHPF (NM_019015)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHPF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHPF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHPF
    OriGene qSTAR qPCR primer pairs in human, mouse for CHPF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHPF
      QuantiTect SYBR Green Assays in human, mouse, rat CHPF
      QuantiFast Probe-based Assays in human, mouse, rat CHPF

    Additional mRNA sequence: 

    AB086063.1 AB095813.1 AK026331.1 AK302124.1 AL136814.1 AY358403.1 BC008878.2 BC021223.2 
    BC023531.2 

    13 DOTS entries:

    DT.80100285  DT.95237072  DT.95254271  DT.92443445  DT.100816215  DT.92443448  DT.95082282  DT.120936758 
    DT.75129966  DT.75143762  DT.87016912  DT.95095605  DT.95254184 

    Selected AceView cDNA sequences (see all 368):

    CN481326 CA391816 BM798906 BU172149 BF348020 CA412127 AI951360 CA441371 
    AA429049 BU173535 AI570655 BU167828 AI766929 BI824221 BQ574153 BG154180 
    CR607445 Z39907 BF436041 AI183874 BX114215 BU184549 BU145447 CB215231 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CHPF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCACACCCC
    CHPF Expression
    About this image

    CHPF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHPF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516711

    UniProtKB/Swiss-Prot: CHSS2_HUMAN, Q8IZ52
    Tissue specificity: Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney,
    liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen,
    ovary, testis, lung and peripheral mononuclear cells

        Custom PCR Arrays for CHPF
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHPF
    OriGene qSTAR qPCR primer pairs in human, mouse for CHPF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHPF
    QuantiTect SYBR Green Assays in human, mouse, rat CHPF
    QuantiFast Probe-based Assays in human, mouse, rat CHPF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHPF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CHPF gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chpf1 , 5 chondroitin polymerizing factor1, 5 87.04(n)1
    94.44(a)1
      1 (39.14 cM)5
    742411  NM_001001566.31  NP_001001566.11 
     754745695 
    chicken
    (Gallus gallus)
    Aves CHPF1 chondroitin polymerizing factor 70.76(n)
    63.57(a)
      769112  XM_001232316.2  XP_001232317.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.67612 Xenopus laevis transcribed sequence with weak similarity more 73.78(n)    BJ627398.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.136072 Transcribed sequence with weak similarity to protein more 77.62(n)    BI868106.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG433131 CG43313 46.17(n)
    32.01(a)
      32259  NM_132625.2  NP_572853.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mig-221 mig-22 40.43(n)
    31.13(a)
      176231  NM_066533.4  NP_498934.1 


    ENSEMBL Gene Tree for CHPF (if available)
    TreeFam Gene Tree for CHPF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CHPF gene
    CSGALNACT12  CHSY32  B4GALNT32  CSGALNACT22  CHSY12  CHPF22  B4GALNT42  
    1 SIMAP similar gene for CHPF using alignment to 2 protein entries:     CHSS2_HUMAN (see all proteins):
    CHPF2

    Find genes that share paralogs with CHPF           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CHPF (see all 162)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813993511,2
    --212256202(+) AGGGAA/CAGCCA 2 -- ds50010--------
    rs1843924821,2
    --212256219(+) CAGCCC/TCAATG 2 -- ds50010--------
    rs1884426061,2
    --212256364(+) CTGCAC/TCAGCC 2 -- ds50010--------
    rs1440234651,2
    --212256405(+) GGCAGA/GAGACC 2 -- ds50010--------
    rs1812932861,2
    --212256495(+) GCTGAC/TGAGAT 2 -- ds50010--------
    rs1860312101,2
    --212256563(+) GGGGCC/TGGGGT 2 -- ds50010--------
    rs1393343891,2
    --212256604(+) GGTGAA/GAGGAA 2 -- ds50010--------
    rs9071441,2
    C,F,A,H--212256681(+) CTACCC/TTTTCA 2 -- ds500126Minor allele frequency- T:0.07NS EA NA WA CSA 2039
    rs1133164661,2
    C--212256704(+) CACAAC/G/TTCCAC 4 -- ut311CSA 1
    rs1500736511,2
    --212256742(+) GCTTCA/GGCAGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CHPF (220403669 - 220408509 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CHPF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508887CNV Insertion20534489
    dgv4438n71CNV Loss21882294
    nsv875876CNV Loss21882294
    nsv520958CNV Loss19592680
    nsv834545CNV Loss17160897
    nsv875875CNV Loss21882294
    nsv482056CNV Gain20164927

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHPF
    DNA2.0 Custom Variant and Variant Library Synthesis for CHPF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610405    OMIM disorders: --


    Find genes that share disorders with CHPF           About GenesLikeMe


    Export disorders for CHPF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CHPF gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CHPF)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. (PubMed id 12716890)1, 2, 3, 9 Kitagawa H.... Sugahara K. (J. Biol. Chem. 2003)
    2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    3. Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities. (PubMed id 12761225)1, 2, 9 Yada T.... Kimata K. (J. Biol. Chem. 2003)
    4. Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential. (PubMed id 22082830)1, 2 Kuroda Y....Mitsui T. (Hum. Mol. Genet. 2012)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    8. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)
    9. FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. (PubMed id 22461910)1 Teh M.T....Hutchison I.L. (PLoS ONE 2012)
    10. Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer. (PubMed id 21468578)1 Kalathas D....Vynios D.H. (Mol Med Rep 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79586 HGNC: 24291 AceView: CHPF Ensembl:ENSG00000123989 euGenes: HUgn79586
    ECgene: CHPF Kegg: 79586 H-InvDB: CHPF

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CHPF Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=CHPF

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CHPF gene:
    Search GeneIP for patents involving CHPF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CHPF   OriGene RNAi products in human, mouse, rat for CHPF  
     OriGene qPCR primer pairs and template standards for CHPF   OriGene Protein Over-expression Lysate for CHPF  
     OriGene MassSpec something-or-other for CHPF   OriGene clones in human, mouse for CHPF  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHPF   OriGene Purified Protein for CHPF  
     OriGene ORF clones in mouse, rat for CHPF   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHPF   OriGene Custom Protein Services for CHPF  

     
     
     Block miRNA regulation of human, mouse, rat CHPF using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CHPF
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHPF Predesigned siRNA for gene silencing in human, mouse, rat CHPF
     QuantiFast Probe-based Assays in human, mouse, rat CHPF QuantiTect SYBR Green Assays in human, mouse, rat CHPF
     Custom PCR Arrays for CHPF Search Chromatin IP Primers for CHPF
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHPF  GeneGlobe Interaction Network for CHPF
     Regulatory tfbs in CHPF promoter
     GenScript Custom Purified and Recombinant Proteins Services for CHPF GenScript cDNA clones with any tag delivered in your preferred vector for CHPF
     GenScript Custom Assay Services for CHPF GenScript Custom overexpressing Cell Line Services for CHPF
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CHPF (CHSS2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CHPF antibodies
     CHPF lysates
     Antibodies for CHPF
     See all of Abcam's Antibodies, Kits and Proteins for CHPF
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CHPF
     Antibodies for CHPF
     ELISAs for CHPF
     CLIAs for CHPF



     Browse ESI BIO Cell Lines and PureStem Progenitors for CHPF
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHPF
     SwitchGear 3'UTR luciferase reporter plasmids for CHPF
     SwitchGear Promoter luciferase reporter plasmids for CHPF
     ThermoFisher Antibody for CHPF
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHPF
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHPF
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHPF
     LSBio Antibodies in human, mouse, rat for CHPF
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CHPF
      Search eBioscience for proteins for CHPF
      Search eBioscience for elisas for CHPF
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHPF gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4