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Aliases for CHPF Gene

Aliases for CHPF Gene

  • Chondroitin Polymerizing Factor 2 3 5
  • Glucuronosyl-N-Acetylgalactosaminyl-Proteoglycan 4-Beta-N-Acetylgalactosaminyltransferase II 3 4
  • N-Acetylgalactosaminyl-Proteoglycan 3-Beta-Glucuronosyltransferase II 3 4
  • Chondroitin Glucuronyltransferase 2 3 4
  • N-Acetylgalactosaminyltransferase 2 3 4
  • Chondroitin-Polymerizing Factor 3 4
  • CSS2 3 4
  • Chondroitin Sulfate Synthase 2 2
  • EC 2.4.1.175 4
  • EC 2.4.1.226 4
  • CHSY2 3
  • ChPF 4

External Ids for CHPF Gene

Previous GeneCards Identifiers for CHPF Gene

  • GC02M220367
  • GC02M220606
  • GC02M220229
  • GC02M220111
  • GC02M212256

Summaries for CHPF Gene

GeneCards Summary for CHPF Gene

CHPF (Chondroitin Polymerizing Factor) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include transferase activity, transferring glycosyl groups and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. An important paralog of this gene is B4GALNT4.

UniProtKB/Swiss-Prot for CHPF Gene

  • Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress.

Gene Wiki entry for CHPF Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHPF Gene

Genomics for CHPF Gene

Regulatory Elements for CHPF Gene

Promoters for CHPF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHPF on UCSC Golden Path with GeneCards custom track

Genomic Location for CHPF Gene

Chromosome:
2
Start:
219,538,947 bp from pter
End:
219,543,787 bp from pter
Size:
4,841 bases
Orientation:
Minus strand

Genomic View for CHPF Gene

Genes around CHPF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHPF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHPF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHPF Gene

Proteins for CHPF Gene

  • Protein details for CHPF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ52-CHSS2_HUMAN
    Recommended name:
    Chondroitin sulfate synthase 2
    Protein Accession:
    Q8IZ52
    Secondary Accessions:
    • B4DXU0
    • Q6UXD6
    • Q7L4G1
    • Q9H0F8
    • Q9H618

    Protein attributes for CHPF Gene

    Size:
    775 amino acids
    Molecular mass:
    85467 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Name=Co(2+); Xref=ChEBI:CHEBI:48828;
    Quaternary structure:
    • Binds CHSY1. Isoform 1, isoform 2 and isoform 3 interact with PARK2.

    Alternative splice isoforms for CHPF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHPF Gene

Proteomics data for CHPF Gene at MOPED

Post-translational modifications for CHPF Gene

  • Glycosylation at Asn 138 and Asn 361
  • Modification sites at PhosphoSitePlus

Other Protein References for CHPF Gene

Antibody Products

No data available for DME Specific Peptides for CHPF Gene

Domains & Families for CHPF Gene

Protein Domains for CHPF Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHPF Gene

Graphical View of Domain Structure for InterPro Entry

Q8IZ52

UniProtKB/Swiss-Prot:

CHSS2_HUMAN :
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
Family:
  • Belongs to the chondroitin N-acetylgalactosaminyltransferase family.
genes like me logo Genes that share domains with CHPF: view

Function for CHPF Gene

Molecular function for CHPF Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan.
UniProtKB/Swiss-Prot CatalyticActivity:
UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.
UniProtKB/Swiss-Prot Function:
Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PARK2 transport into the mitochondria. In collaboration with PARK2, isoform 2 may enhance cell viability and protect cells from oxidative stress.

Enzyme Numbers (IUBMB) for CHPF Gene

Gene Ontology (GO) - Molecular Function for CHPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22082830
GO:0008376 acetylgalactosaminyltransferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IEA,TAS --
genes like me logo Genes that share ontologies with CHPF: view
genes like me logo Genes that share phenotypes with CHPF: view

Animal Models for CHPF Gene

MGI Knock Outs for CHPF:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHPF

miRNA for CHPF Gene

miRTarBase miRNAs that target CHPF

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHPF Gene

Localization for CHPF Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHPF Gene

Isoform 1: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cytoplasm, cytosol.
Isoform 3: Cytoplasm, cytosol. Mitochondrion.
Isoform 2: Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHPF Gene COMPARTMENTS Subcellular localization image for CHPF gene
Compartment Confidence
golgi apparatus 5
cytosol 4
mitochondrion 4
cytoskeleton 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CHPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with CHPF: view

Pathways & Interactions for CHPF Gene

genes like me logo Genes that share pathways with CHPF: view

Gene Ontology (GO) - Biological Process for CHPF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0030206 chondroitin sulfate biosynthetic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CHPF: view

No data available for SIGNOR curated interactions for CHPF Gene

Drugs & Compounds for CHPF Gene

(4) Drugs for CHPF Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine-5'-Diphosphate Experimental Pharma 0
Cobalt Pharma 155
Manganese Pharma 32

(5) Additional Compounds for CHPF Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Lactosamine
  • 2-Amino-2-deoxy-4-O-beta-D-galactopyranosyl-D-glucose
  • 2-Amino-2-deoxy-4-O-beta-delta-galactopyranosyl-delta-glucose
  • beta-D-Galactopyranosyl-(1->4)-2-amino-2-deoxy-D-glucose
  • beta-D-Galactopyranosyl-(1->4)-D-glucosamine
  • beta-delta-Galactopyranosyl-(1->4)-2-amino-2-deoxy-delta-glucose
13000-25-4
UDP-N-acetyl-alpha-D-galactosamine
Uridine diphosphate glucuronic acid
  • a-D-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • a-D-Glucopyranuronic acid ester with uridine 5'-pyrophosphate
  • alpha-D-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
  • alpha-delta-Glucopyranuronic acid 1->5'-ester with uridine 5'-(trihydrogen pyrophosphate)
  • alpha-delta-Glucopyranuronic acid 1-P'-ester with uridine 5'-(trihydrogen diphosphate)
2616-64-0
Uridine diphosphate-N-acetylgalactosamine
  • UDP-N-Acetyl-D-galactosamine
  • UDP-N-Acetyl-delta-galactosamine
  • UDP-N-Acetylgalactosamine
  • Uridine 5'-diphospho-N-acetylgalactosamine
  • Uridine diphosphate-N-acetyl-D-galactosamine
7277-98-7
genes like me logo Genes that share compounds with CHPF: view

Transcripts for CHPF Gene

Unigene Clusters for CHPF Gene

Chondroitin polymerizing factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHPF Gene

No ASD Table

Relevant External Links for CHPF Gene

GeneLoc Exon Structure for
CHPF
ECgene alternative splicing isoforms for
CHPF

Expression for CHPF Gene

mRNA expression in normal human tissues for CHPF Gene

Protein differential expression in normal tissues from HIPED for CHPF Gene

This gene is overexpressed in Breast (50.0) and Testis (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHPF Gene



SOURCE GeneReport for Unigene cluster for CHPF Gene Hs.516711

mRNA Expression by UniProt/SwissProt for CHPF Gene

Q8IZ52-CHSS2_HUMAN
Tissue specificity: Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells.
genes like me logo Genes that share expression patterns with CHPF: view

Protein tissue co-expression partners for CHPF Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHPF Gene

Orthologs for CHPF Gene

This gene was present in the common ancestor of animals.

Orthologs for CHPF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHPF 36
  • 99 (a)
OneToOne
CHPF 35
  • 99.1 (n)
  • 99.1 (a)
cow
(Bos Taurus)
Mammalia CHPF 35
  • 90.19 (n)
  • 95.87 (a)
CHPF 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHPF 35
  • 89.39 (n)
  • 95.86 (a)
mouse
(Mus musculus)
Mammalia Chpf 36
  • 94 (a)
OneToOne
Chpf 16
Chpf 35
  • 87.04 (n)
  • 94.44 (a)
oppossum
(Monodelphis domestica)
Mammalia CHPF 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 14 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Chpf 35
  • 86.88 (n)
  • 94.03 (a)
chicken
(Gallus gallus)
Aves CHPF 35
  • 70.76 (n)
  • 63.57 (a)
-- 36
  • 62 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6761 35
tropical clawed frog
(Silurana tropicalis)
Amphibia chpf 35
  • 65.85 (n)
  • 61.07 (a)
zebrafish
(Danio rerio)
Actinopterygii chpf2 36
  • 51 (a)
OneToMany
chpfa 35
  • 58.65 (n)
  • 54.51 (a)
Dr.13607 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001050 35
  • 40.79 (n)
  • 30.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43313 35
  • 46.17 (n)
  • 32.01 (a)
CG43313 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mig-22 35
  • 40.43 (n)
  • 31.13 (a)
mig-22 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5086 36
  • 36 (a)
OneToMany
Species with no ortholog for CHPF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHPF Gene

ENSEMBL:
Gene Tree for CHPF (if available)
TreeFam:
Gene Tree for CHPF (if available)

Paralogs for CHPF Gene

(1) SIMAP similar genes for CHPF Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHPF: view

Variants for CHPF Gene

Sequence variations from dbSNP and Humsavar for CHPF Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs6436155 - 219,540,599(+) CTGCC(C/T)GGTCC reference, missense
rs1976616 -- 219,539,659(+) GCCAC(A/G)TAGTC reference, synonymous-codon
rs3180308 -- 219,541,460(-) CCTGG(A/G)CTTCA intron-variant
rs6722853 -- 219,539,997(+) CAGCT(A/C/T)TGCCA reference, missense, stop-gained
rs11556309 -- 219,539,330(+) TTGGG(A/G)TGAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CHPF Gene

Variant ID Type Subtype PubMed ID
nsv520958 CNV Loss 19592680
dgv4438n71 CNV Loss 21882294
nsv875875 CNV Loss 21882294
nsv875876 CNV Loss 21882294
nsv834545 CNV Loss 17160897
nsv508887 CNV Insertion 20534489
nsv482056 CNV Gain 20164927

Variation tolerance for CHPF Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHPF Gene

HapMap Linkage Disequilibrium report
CHPF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHPF Gene

Disorders for CHPF Gene

Relevant External Links for CHPF

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHPF

No disorders were found for CHPF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHPF Gene

Publications for CHPF Gene

  1. Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization. (PMID: 12716890) Kitagawa H. … Sugahara K. (J. Biol. Chem. 2003) 2 3 4 23 67
  2. Chondroitin sulfate synthase-2. Molecular cloning and characterization of a novel human glycosyltransferase homologous to chondroitin sulfate glucuronyltransferase, which has dual enzymatic activities. (PMID: 12761225) Yada T. … Kimata K. (J. Biol. Chem. 2003) 3 23
  3. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3

Products for CHPF Gene

Sources for CHPF Gene

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