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CHP2 Gene

protein-coding   GIFtS: 48
GCID: GC16P023765

Calcineurin-Like EF-Hand Protein 2

  See CHP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcineurin-Like EF-Hand Protein 21 2
Hepatocellular Carcinoma-Associated Antigen 5202 3
Calcineurin B Homologous Protein 22
Calcineurin-Like EF Hand Protein 22
Hepatocellular Carcinoma Antigen Gene 5202
HCA5203

External Ids:    HGNC: 249271   Entrez Gene: 639282   Ensembl: ENSG000001668697   UniProtKB: O437453   

Export aliases for CHP2 gene to outside databases

Previous GC identifers: GC16P023674 GC16P021855


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHP2 Gene:
This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type
Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and
stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear
factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous
protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype
associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated
antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. (provided by RefSeq,
Jul 2013)

GeneCards Summary for CHP2 Gene:
CHP2 (calcineurin-like EF-hand protein 2) is a protein-coding gene. Diseases associated with CHP2 include hepatocellular carcinoma. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CIB1.

UniProtKB/Swiss-Prot: CHP2_HUMAN, O43745
Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+)
exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and
protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation
and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the
calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3
to the nucleus




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHP2 gene promoter:
         AhR   Spz1   GATA-3   POU3F2   Evi-1   AREB6   PPAR-alpha   SRY   c-Myb   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHP2 promoter sequence
   Search Chromatin IP Primers for CHP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p12.2   Ensembl cytogenetic band:  16p12.2   HGNC cytogenetic band: 16p12.2

CHP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHP2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P023765:  view genomic region     (about GC identifiers)

Start:
23,765,948 bp from pter      End:
23,770,272 bp from pter
Size:
4,325 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHP2_HUMAN, O43745 (See protein sequence)
Recommended Name: Calcineurin B homologous protein 2  
Size: 196 amino acids; 22452 Da
Subunit: Interacts with PPP3CA. Interacts with SLC9A1/NHE1; the interaction occurs in a calcium-dependent manner
1 PDB 3D structure from and Proteopedia for CHP2:
2BEC (3D)    
Secondary accessions: A8K2I8

Explore the universe of human proteins at neXtProt for CHP2: NX_O43745

Explore proteomics data for CHP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CHP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071380.1  
    ENSEMBL proteins: 
     ENSP00000300113  

    CHP2 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for CHP2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    3 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry O43745

    ProtoNet protein and cluster: O43745

    UniProtKB/Swiss-Prot: CHP2_HUMAN, O43745
    Similarity: Belongs to the calcineurin regulatory subunit family. CHP subfamily
    Similarity: Contains 4 EF-hand domains


    Find genes that share domains with CHP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHP2_HUMAN, O43745
    Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+)
    exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and
    protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation
    and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the
    calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3
    to the nucleus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IDA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with CHP2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Chp2 (no phenotypes)

    Find genes that share phenotypes with CHP2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHP2
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    miRNA
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    Block miRNA regulation of human, mouse, rat CHP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHP2 (see all 14):
    hsa-miR-4254 hsa-miR-224 hsa-miR-328 hsa-miR-19b-2* hsa-miR-4251 hsa-miR-1236 hsa-miR-216b hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCHP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CHP2

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    GenScript: all cDNA clones in your preferred vector: CHP2 (NM_022097)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHP2_HUMAN, O43745: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region.
    Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the
    nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol3
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with CHP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Alzheimer's disease
    Alzheimers Disease0.44


    1 BioSystems Pathway for CHP2
        Alzheimers Disease


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHP2
    Interactions:

        GeneGlobe Interaction Network for CHP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHP2 (O437452, 3 ENSP000003001134) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A1P196342, 3, ENSP000002639804MINT-2729935 I2D: score=3 STRING: ENSP00000263980
    SLC9A3P487643, ENSP000002649384I2D: score=2 STRING: ENSP00000264938
    SLC9A2Q9UBY03, ENSP000002339694I2D: score=1 STRING: ENSP00000233969
    SLC9A5Q149403, ENSP000002997984I2D: score=1 STRING: ENSP00000299798
    SLC9A4Q6AI143, ENSP000002952694I2D: score=1 STRING: ENSP00000295269
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IDA18815128
    GO:0010922positive regulation of phosphatase activity IDA18815128
    GO:0015031protein transport IEA--
    GO:0042307positive regulation of protein import into nucleus IDA18815128
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA18815128

    Find genes that share ontologies with CHP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHP2 gene: 
    NM_022097.3  

    Unigene Cluster for CHP2:

    Calcineurin-like EF-hand protein 2
    Hs.178589  [show with all ESTs]
    Unigene Representative Sequence: AF146019
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000300113(uc002dmb.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CHP2 (see all 14):
    hsa-miR-4254 hsa-miR-224 hsa-miR-328 hsa-miR-19b-2* hsa-miR-4251 hsa-miR-1236 hsa-miR-216b hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidCHP2 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: CHP2 (NM_022097)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHP2
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      QuantiTect SYBR Green Assays in human, mouse, rat CHP2
      QuantiFast Probe-based Assays in human, mouse, rat CHP2

    Additional mRNA sequence: 

    AF146019.1 AK096977.1 AK290253.1 AK313062.1 

    2 DOTS entries:

    DT.208555  DT.99930779 

    Selected AceView cDNA sequences (see all 37):

    BX351351 BF056925 AI675204 BX483271 AW051613 BF223890 AW004627 AA298640 
    BX334879 AI826786 BV191042 AA435717 AW958201 AI880669 AI273289 AA514619 
    BE464370 AI659333 BG152541 AA527435 NM_022097 BI754025 AA397980 BX371534 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAGGATGAT
    CHP2 Expression
    About this image


    CHP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord
    CHP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.178589

    UniProtKB/Swiss-Prot: CHP2_HUMAN, O43745
    Tissue specificity: Expressed in malignantly transformed cells but not detected in normal tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chp21 , 5 RIKEN cDNA 2010110P09 gene5
    calcineurin-like EF hand protein 21
    83.84(n)1
    81.63(a)1
      7 (65.62 cM)5
    702611  NM_027363.11  NP_081639.11 
     1222194965 
    lizard
    (Anolis carolinensis)
    Reptilia CHP26
    calcineurin-like EF-hand protein 2
    64(a)
    1 ↔ 1
    GL343635.1(219076-229772)
    zebrafish
    (Danio rerio)
    Actinopterygii chp21 calcineurin-like EF hand protein 2 64.95(n)
    58.76(a)
      327599  NM_199836.2  NP_956130.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta elm6
    ethanol sensitive with low memory
    49(a)
    1 → many
    3R(1478555-1480613)
    worm
    (Caenorhabditis elegans)
    Secernentea pbo-11 pbo-1 53.62(n)
    48.37(a)
      175385  NM_065200.3  NP_497601.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNB16
    Calcineurin B; the regulatory subunit of calcineur...
    38(a)
    1 → many
    XI(82947-83550) YKL190W


    ENSEMBL Gene Tree for CHP2 (if available)
    TreeFam Gene Tree for CHP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHP2 gene
    CIB12  CIB32  PPP3R12  PPP3R22  ENSG000002733982  WDR922  CIB42  CIB22  
    CHP12  
    5 SIMAP similar genes for CHP2 using alignment to 1 protein entry:     CHP2_HUMAN:
    CHP1    HZGJ    TESC    PPP3R1    PPP3R2

    Find genes that share paralogs with CHP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHP2 (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1830419491,2
    --23763971(+) GCGGTA/GCTTAT 1 -- us2k10--------
    rs1408844571,2
    --23763985(+) AGCTTC/TTTAGG 1 -- us2k10--------
    rs1501824291,2
    --23763987(+) CTTCTC/TAGGGC 1 -- us2k10--------
    rs1876782681,2
    --23764102(+) TTTCCC/TGCATG 1 -- us2k10--------
    rs792903231,2
    C,F--23764268(+) TTCTTC/TAGCTT 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1178210451,2
    C,F--23764333(+) TTTTCC/TCCCCT 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs99317981,2
    H--23764444(+) TCTCGA/TCCTGT 1 -- us2k14Minor allele frequency- T:0.00NS EA 414
    rs1118250741,2
    C--23764448(+) ACCTGT/-TTTTT 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs118634331,2
    C,F,H--23764458(+) TTTTTC/TATTAT 1 -- us2k1 trp36Minor allele frequency- T:0.03NS EA NA WA 528
    rs118634651,2
    C,F,H--23764496(+) CCCCAC/GCCTCA 1 -- us2k12Minor allele frequency- G:0.14NA WA 120

    HapMap Linkage Disequilibrium report for CHP2 (23765948 - 23770272 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CHP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510681CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHP2
    DNA2.0 Custom Variant and Variant Library Synthesis for CHP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for CHP2:    
    About MalaCards
    hepatocellular carcinoma


    Find genes that share disorders with CHP2           About GenesLikeMe

    Genetic Association Database (GAD): CHP2

    Export disorders for CHP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHP2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CHP2)
        Utopia: connect your pdf to the dynamic
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    1. Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. (PubMed id 12226101)1, 2, 3, 9 Pang T.... Shigekawa M. (J. Biol. Chem. 2002)
    2. Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women. (PubMed id 21507922)1, 4 Ramsuran V....Ndung'u T. (Clin. Infect. Dis. 2011)
    3. Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells. (PubMed id 21392185)1, 2 Li Q.H....Pang T.X. (Genes Cells 2011)
    4. CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. (PubMed id 18815128)1, 2 Li G.D.... Zhang Y. (J. Biol. Chem. 2008)
    5. Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation. (PubMed id 16710297)1, 2 Ammar Y.B.... Wakabayashi S. (EMBO J. 2006)
    6. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2 Wang Y....Chen W.-F. (J. Immunol. 2002)
    7. Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer. (PubMed id 17708351)1, 9 Jin Q....Yang Q. (In Vivo 2007)
    8. Calcineurin homologous protein: a multifunctional Ca2+-binding protein family. (PubMed id 22189947)1 Di Sole F....Babich V. (Am. J. Physiol. Renal Physiol. 2012)
    9. [Expression of a tumor related gene chp2 in leukemia cells]. (PubMed id 18718049)1 Li B....Pang T.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2008)
    10. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63928 HGNC: 24927 AceView: LOC63928 Ensembl:ENSG00000166869 euGenes: HUgn63928
    ECgene: CHP2 H-InvDB: CHP2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHP2 gene:
    Search GeneIP for patents involving CHP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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