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Aliases for CHP2 Gene

Aliases for CHP2 Gene

  • Calcineurin-Like EF-Hand Protein 2 2 3
  • Hepatocellular Carcinoma-Associated Antigen 520 4
  • HCA520 4

External Ids for CHP2 Gene

Previous GeneCards Identifiers for CHP2 Gene

  • GC16P023674
  • GC16P021855

Summaries for CHP2 Gene

Entrez Gene Summary for CHP2 Gene

  • This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]

GeneCards Summary for CHP2 Gene

CHP2 (Calcineurin-Like EF-Hand Protein 2) is a Protein Coding gene. Diseases associated with CHP2 include hepatocellular carcinoma. Among its related pathways are Alzheimers disease. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

UniProtKB/Swiss-Prot for CHP2 Gene

  • Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHP2 Gene

Genomics for CHP2 Gene

Regulatory Elements for CHP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHP2 Gene

Start:
23,754,627 bp from pter
End:
23,758,951 bp from pter
Size:
4,325 bases
Orientation:
Plus strand

Genomic View for CHP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHP2 Gene

Proteins for CHP2 Gene

  • Protein details for CHP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43745-CHP2_HUMAN
    Recommended name:
    Calcineurin B homologous protein 2
    Protein Accession:
    O43745
    Secondary Accessions:
    • A8K2I8

    Protein attributes for CHP2 Gene

    Size:
    196 amino acids
    Molecular mass:
    22452 Da
    Quaternary structure:
    • Interacts with PPP3CA. Interacts with SLC9A1/NHE1; the interaction occurs in a calcium-dependent manner.

    Three dimensional structures from OCA and Proteopedia for CHP2 Gene

neXtProt entry for CHP2 Gene

Proteomics data for CHP2 Gene at MOPED

Post-translational modifications for CHP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHP2 Gene

Domains for CHP2 Gene

Gene Families for CHP2 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CHP2 Gene

Suggested Antigen Peptide Sequences for CHP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43745

UniProtKB/Swiss-Prot:

CHP2_HUMAN :
  • O43745
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
genes like me logo Genes that share domains with CHP2: view

Function for CHP2 Gene

Molecular function for CHP2 Gene

UniProtKB/Swiss-Prot Function: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.

Gene Ontology (GO) - Molecular Function for CHP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 21392185
GO:0005515 protein binding IPI 21392185
genes like me logo Genes that share ontologies with CHP2: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHP2 Gene

Localization for CHP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHP2 Gene

Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane (By similarity). Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHP2 Gene COMPARTMENTS Subcellular localization image for CHP2 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for CHP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21392185
GO:0005737 cytoplasm IDA 21392185
GO:0005886 plasma membrane IDA 21392185
genes like me logo Genes that share ontologies with CHP2: view

Pathways for CHP2 Gene

SuperPathways for CHP2 Gene

Superpath Contained pathways
1 Alzheimers disease
genes like me logo Genes that share pathways with CHP2: view

Pathways by source for CHP2 Gene

1 BioSystems pathway for CHP2 Gene

Gene Ontology (GO) - Biological Process for CHP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 18815128
GO:0010922 positive regulation of phosphatase activity IDA 18815128
GO:0015031 protein transport IEA --
GO:0042307 positive regulation of protein import into nucleus IDA 18815128
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 18815128
genes like me logo Genes that share ontologies with CHP2: view

Transcripts for CHP2 Gene

mRNA/cDNA for CHP2 Gene

(37) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHP2 Gene

Calcineurin-like EF-hand protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHP2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CHP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHP2 Gene

No ASD Table

Relevant External Links for CHP2 Gene

GeneLoc Exon Structure for
CHP2
ECgene alternative splicing isoforms for
CHP2

Expression for CHP2 Gene

mRNA expression in normal human tissues for CHP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHP2 Gene

This gene is overexpressed in Colon - Transverse (15.2), Skin - Not Sun Exposed (Suprapubic) (11.3), Skin - Sun Exposed (Lower leg) (10.1), and Small Intestine - Terminal Ileum (9.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHP2 Gene

SOURCE GeneReport for Unigene cluster for CHP2 Gene Hs.178589

mRNA Expression by UniProt/SwissProt for CHP2 Gene

O43745-CHP2_HUMAN
Tissue specificity: Expressed in malignantly transformed cells but not detected in normal tissues.
genes like me logo Genes that share expressions with CHP2: view

In Situ Assay Products

Orthologs for CHP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHP2 35
  • 99.83 (n)
  • 100 (a)
CHP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHP2 35
  • 85.03 (n)
  • 85.2 (a)
CHP2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHP2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chp2 35
  • 83.84 (n)
  • 81.63 (a)
Chp2 16
Chp2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHP2 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chp2 35
  • 83.84 (n)
  • 81.63 (a)
lizard
(Anolis carolinensis)
Reptilia CHP2 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7594 35
zebrafish
(Danio rerio)
Actinopterygii chp2 35
  • 64.95 (n)
  • 58.76 (a)
chp2 36
  • 58 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta elm 36
  • 49 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F59D6.7 36
  • 45 (a)
ManyToMany
pbo-1 35
  • 53.62 (n)
  • 48.37 (a)
pbo-1 36
  • 44 (a)
ManyToMany
ZK856.8 36
  • 46 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 36
  • 38 (a)
OneToMany
Species with no ortholog for CHP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHP2 Gene

ENSEMBL:
Gene Tree for CHP2 (if available)
TreeFam:
Gene Tree for CHP2 (if available)

Paralogs for CHP2 Gene

Paralogs for CHP2 Gene

Selected SIMAP similar genes for CHP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHP2: view

Variants for CHP2 Gene

Sequence variations from dbSNP and Humsavar for CHP2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs80950 -- 23,757,481(+) GAGCA(G/T)GGAGA intron-variant
rs109592 -- 23,757,389(+) GGAAA(C/T)GTTCA intron-variant
rs152041 -- 23,754,034(+) TGAAC(C/G)GATGC upstream-variant-2KB
rs152042 -- 23,754,252(+) TGGCC(A/G)GAAGA upstream-variant-2KB
rs194820 -- 23,755,280(+) GGTTA(A/G)GGGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHP2 Gene

Variant ID Type Subtype PubMed ID
nsv510681 CNV Loss 20534489

Relevant External Links for CHP2 Gene

HapMap Linkage Disequilibrium report
CHP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHP2 Gene

Disorders for CHP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CHP2 Gene including...

Search for CHP2 Gene in MalaCards »

Relevant External Links for CHP2

Genetic Association Database (GAD)
CHP2
genes like me logo Genes that share disorders with CHP2: view

No data available for UniProtKB/Swiss-Prot for CHP2 Gene

Publications for CHP2 Gene

  1. Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger. (PMID: 12226101) Pang T. … Shigekawa M. (J. Biol. Chem. 2002) 2 3 4 23
  2. Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer. (PMID: 17708351) Jin Q. … Yang Q. (In Vivo 2007) 3 23
  3. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 3 4
  4. Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation. (PMID: 16710297) Ammar Y.B. … Wakabayashi S. (EMBO J. 2006) 3 4
  5. CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. (PMID: 18815128) Li G.D. … Zhang Y. (J. Biol. Chem. 2008) 3 4

Products for CHP2 Gene

Sources for CHP2 Gene

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