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CHP1 Gene(Protein Coding)

Calcineurin Like EF-Hand Protein 1

GCID:
GC15P041230
GIFtS:
46
Genes Participants
UDN Logo

Aliases for CHP1 Gene

Aliases for CHP1 Gene

  • Calcineurin Like EF-Hand Protein 1 2 3 5
  • EF-Hand Calcium-Binding Domain-Containing Protein P22 3 4
  • Calcineurin Homologous Protein 2 3
  • Calcium-Binding Protein CHP 3 4
  • Calcium-Binding Protein P22 3 4
  • Calcineurin B-Like Protein 3 4
  • CHP 3 4
  • Calcineurin B Homologous Protein 1 3
  • Calcium Binding Protein P22 3
  • SLC9A1 Binding Protein 3
  • Calcineurin B Homolog 3
  • SLC9A1BP 3
  • Sid470p 3
  • P24 3
  • P22 3

External Ids for CHP1 Gene

Previous GeneCards Identifiers for CHP1 Gene

  • GC15P041524

Summaries for CHP1 Gene

Entrez Gene Summary for CHP1 Gene

  • This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHP1 Gene

CHP1 (Calcineurin Like EF-Hand Protein 1) is a Protein Coding gene. Among its related pathways are Role of Calcineurin-dependent NFAT signaling in lymphocytes and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include calcium ion binding and microtubule binding. An important paralog of this gene is CHP2.

UniProtKB/Swiss-Prot for CHP1 Gene

  • Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

Gene Wiki entry for CHP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHP1 Gene

Genomics for CHP1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CHP1 Gene

Enhancers for CHP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G040905 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -323.9 -323919 3.7 HDGF ATF1 AGO1 ARID4B SIN3A ZNF2 YY1 ZNF121 GLIS2 ZNF143 CHAC1 RHOV CHP1 EXD1 DLL4 ENSG00000251161
GH15G041259 1.2 Ensembl ENCODE 12.1 +28.6 28564 2.0 PKNOX1 FOXA2 MLX ARID4B DMAP1 BRCA1 ZNF48 YY1 SP5 MXD4 EXD1 CHP1 ENSG00000251161 VPS18 OIP5 NUSAP1 RTF1 GC15M041261 GC15M041262 GC15M041263
GH15G040909 1.3 Ensembl ENCODE dbSUPER 10.3 -320.1 -320106 2.4 ELF3 ZNF48 RARA YY1 THAP11 CEBPB ZNF398 NR2F2 CEBPA ETV4 CHAC1 SPINT1 CHP1 EXD1 ZFYVE19 ENSG00000251161 DLL4
GH15G041282 1.1 ENCODE 11.3 +54.0 53958 3.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 NDUFAF1 RPAP1 GANC NUSAP1 OIP5 BAHD1 CHP1 EXD1 RTF1 ZFYVE19
GH15G041290 1 Ensembl ENCODE 11.3 +60.8 60814 1.9 PKNOX1 TFAP4 SAP130 CEBPG ZNF121 NR2F6 RELB IKZF2 BHLHE40 NR2F1 NDUFAF1 NUSAP1 OIP5 EXD1 CHP1 RNU6-1169P RTF1 ZFYVE19 OIP5-AS1 PIR39466
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHP1 on UCSC Golden Path with GeneCards custom track

Promoters for CHP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000075621 561 2001 CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1

Genomic Location for CHP1 Gene

Chromosome:
15
Start:
41,230,839 bp from pter
End:
41,281,890 bp from pter
Size:
51,052 bases
Orientation:
Plus strand

Genomic View for CHP1 Gene

Genes around CHP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHP1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CHP1 Gene

Proteins for CHP1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CHP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99653-CHP1_HUMAN
    Recommended name:
    Calcineurin B homologous protein 1
    Protein Accession:
    Q99653
    Secondary Accessions:
    • B2R6H9
    • Q6FHZ9

    Protein attributes for CHP1 Gene

    Size:
    195 amino acids
    Molecular mass:
    22456 Da
    Quaternary structure:
    • Monomer. Interacts with STK17B; the interaction occurs in a calcium-independent manner and induces the translocation of CHP1 from the Golgi to the nucleus. Interacts with GAPDH; the interaction is direct, occurs in a N-myristoylation-dependent manner and facilitates the ability of CHP1 to bind microtubules. Interacts with KIF1B (via the C-terminal end of the kinesin-motor domain); the interaction occurs in a calcium-dependent manner. Associates (via C-terminal domain) with microtubules; the association occurs with polymerized microtubules during the cell cycle in a myristoylation- and calcium-independent manner and is enhanced by GAPDH (By similarity). Interacts with PPP3CA. Interacts with SLC9A1/NHE1 (via the juxtamembrane region of the cytoplasmic C-terminal domain); the interaction occurs at the plasma membrane in a calcium-dependent manner and at a domain that is critical for growth factor stimulation of the exchanger.

    Three dimensional structures from OCA and Proteopedia for CHP1 Gene

neXtProt entry for CHP1 Gene

Protein Expression for CHP1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for CHP1 Gene

  • Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic (By similarity). N-myristoylation is required for its association with microtubules and interaction with GAPDH, but not for the constitutive association to membranes.
  • Phosphorylated; decreased phosphorylation is associated with an increase in SLC9A1/NHE1 Na(+)/H(+) exchange activity. Phosphorylation occurs in serum-dependent manner. The phosphorylation state may regulate the binding to SLC9A1/NHE1.
  • Ubiquitination at posLast=4040 and Lys182
  • Modification sites at PhosphoSitePlus

Other Protein References for CHP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHP1 Gene

Domains & Families for CHP1 Gene

Gene Families for CHP1 Gene

HGNC:

Protein Domains for CHP1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99653

UniProtKB/Swiss-Prot:

CHP1_HUMAN :
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
Family:
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.
genes like me logo Genes that share domains with CHP1: view

No data available for Suggested Antigen Peptide Sequences for CHP1 Gene

Function for CHP1 Gene

Products:

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  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
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  7. Flow Cytometry

Molecular function for CHP1 Gene

UniProtKB/Swiss-Prot Function:
Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

Gene Ontology (GO) - Molecular Function for CHP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IEA --
GO:0005215 transporter activity ISS --
GO:0005509 calcium ion binding IEA,IDA 15035633
GO:0005515 protein binding IPI 8901634
GO:0008017 microtubule binding ISS --
genes like me logo Genes that share ontologies with CHP1: view

Phenotypes for CHP1 Gene

MGI mutant phenotypes for CHP1:
inferred from 1 alleles
GenomeRNAi human phenotypes for CHP1:
genes like me logo Genes that share phenotypes with CHP1: view

Animal Model Products

miRNA for CHP1 Gene

miRTarBase miRNAs that target CHP1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHP1 Gene

Localization for CHP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHP1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Endomembrane system. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell membrane. Membrane; Lipid-anchor. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1 at the reticulum endoplasmic and plasma membrane. Colocalizes with STK17B at the plasma membrane. {ECO:0000250 UniProtKB:P61023}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHP1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
nucleus 5
cytoskeleton 4
endoplasmic reticulum 4
cytosol 4
golgi apparatus 4

Gene Ontology (GO) - Cellular Components for CHP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
genes like me logo Genes that share ontologies with CHP1: view

Pathways & Interactions for CHP1 Gene

genes like me logo Genes that share pathways with CHP1: view

Gene Ontology (GO) - Biological Process for CHP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation ISS --
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0006611 protein export from nucleus ISS --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with CHP1: view

No data available for SIGNOR curated interactions for CHP1 Gene

Drugs & Compounds for CHP1 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for CHP1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CHP1 Gene

(2) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHP1 Gene

No ASD Table

Relevant External Links for CHP1 Gene

GeneLoc Exon Structure for
CHP1
ECgene alternative splicing isoforms for
CHP1

Expression for CHP1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHP1 Gene

mRNA expression in normal human tissues for CHP1 Gene
mRNA expression by BioGPS for CHP1 GenemRNA expression by GTEx for CHP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CHP1 Gene

This gene is overexpressed in Bone (48.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHP1 Gene



Protein tissue co-expression partners for CHP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CHP1 Gene:

CHP1

SOURCE GeneReport for Unigene cluster for CHP1 Gene:

Hs.406234

mRNA Expression by UniProt/SwissProt for CHP1 Gene:

Q99653-CHP1_HUMAN
Tissue specificity: Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.

Evidence on tissue expression from TISSUES for CHP1 Gene

  • Liver(4.4)
  • Nervous system(4.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CHP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHP1 Gene

Orthologs for CHP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CHP1 34 35
  • 100 (n)
oppossum
(Monodelphis domestica)
 Mammalia CHP1 35
  • 99 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia CHP1 35
  • 99 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia CHP1 34 35
  • 95.56 (n)
dog
(Canis familiaris)
 Mammalia CHP1 34 35
  • 94.87 (n)
rat
(Rattus norvegicus)
 Mammalia Chp1 34
  • 93.68 (n)
mouse
(Mus musculus)
 Mammalia Chp1 34 16 35
  • 92.31 (n)
chicken
(Gallus gallus)
 Aves CHP1 34 35
  • 84.1 (n)
lizard
(Anolis carolinensis)
 Reptilia CHP1 35
  • 97 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia chp1 34
  • 79.27 (n)
Str.11512 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.6272 34
zebrafish
(Danio rerio)
 Actinopterygii chp1 34 35
  • 77.32 (n)
wufc69b04 34
fruit fly
(Drosophila melanogaster)
 Insecta elm 34 35
  • 61.88 (n)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP001760 34
  • 60.64 (n)
worm
(Caenorhabditis elegans)
 Secernentea ZK856.8 34 35
  • 57.62 (n)
F59D6.7 35
  • 53 (a)
 ManyToMany
pbo-1 35
  • 49 (a)
 ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes CNB1 35
  • 39 (a)
 OneToMany
Species where no ortholog for CHP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHP1 Gene

ENSEMBL:
Gene Tree for CHP1 (if available)
TreeFam:
Gene Tree for CHP1 (if available)

Paralogs for CHP1 Gene

Paralogs for CHP1 Gene

(5) SIMAP similar genes for CHP1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CHP1 Gene

genes like me logo Genes that share paralogs with CHP1: view

Variants for CHP1 Gene

Sequence variations from dbSNP and Humsavar for CHP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000027802 -- 41,255,420(+) GTAAT(C/G)CCAGG intron-variant
rs1000085566 -- 41,249,909(+) GAGAG(G/T)CTACA intron-variant
rs1000184479 -- 41,273,085(+) AATTA(C/T)AGCCC intron-variant
rs1000204348 -- 41,282,084(+) GGCCA(C/T)TTCCC downstream-variant-500B, upstream-variant-2KB
rs1000219978 -- 41,257,983(+) TTGAA(C/G)AGCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHP1 Gene

Variant ID Type Subtype PubMed ID
dgv2580n100 CNV gain 25217958
esv3636239 CNV loss 21293372
nsv1045455 CNV gain 25217958
nsv507778 OTHER sequence alteration 20534489
nsv569231 CNV loss 21841781

Variation tolerance for CHP1 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHP1 Gene

Disorders for CHP1 Gene

Relevant External Links for CHP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHP1

No disorders were found for CHP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHP1 Gene

Publications for CHP1 Gene

  1. Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis. (PMID: 20720019) Jimenez-Vidal M. … Barber D.L. (J. Biol. Chem. 2010) 2 3 4 64
  2. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. (PMID: 8901634) Lin X. … Barber D.L. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 22 64
  3. Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1. (PMID: 17050540) Mishima M. … Kojima C. (J. Biol. Chem. 2007) 3 4 64
  4. Structural characterization of calcineurin B homologous protein 1. (PMID: 15987692) Naoe Y. … Shimizu T. (J. Biol. Chem. 2005) 2 3 64
  5. Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1. (PMID: 16511206) Ben Ammar Y. … Wakabayashi S. (Acta Crystallogr. F 2005) 3 22 64

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