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CHP1 Gene

protein-coding   GIFtS: 49
GCID: GC15P041524

Calcineurin-Like EF-Hand Protein 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Calcineurin-Like EF-Hand Protein 11 2     Sid470p2
CHP2 3 5     Calcineurin B Homolog2
Calcineurin Homologous Protein1 2     Calcineurin B Homologous Protein 12
Calcineurin B-Like Protein2 3     Calcineurin-Like EF Hand Protein 12
Calcium-Binding Protein CHP2 3     Calcium Binding Protein P222
Calcium-Binding Protein P222 3     p222
EF-Hand Calcium-Binding Domain-Containing Protein P222 3     p242
SLC9A1BP2     SLC9A1 Binding Protein2

External Ids:    HGNC: 174331   Entrez Gene: 112612   Ensembl: ENSG000001874467   OMIM: 6069885   UniProtKB: Q996533   

Export aliases for CHP1 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHP1 Gene:
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential
cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic
regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an
endogenous inhibitor of calcineurin activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for CHP1 Gene:
CHP1 (calcineurin-like EF-hand protein 1) is a protein-coding gene. Diseases associated with CHP1 include lateral sclerosis, and amyotrophic lateral sclerosis. GO annotations related to this gene include microtubule binding and calcium ion binding. An important paralog of this gene is CIB1.

UniProtKB/Swiss-Prot: CHP1_HUMAN, Q99653
Function: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking,
plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane
traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum
and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the
plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type
Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic
pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and
GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing
the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to
the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT
signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the
calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the
apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent
manner

Gene Wiki entry for CHP1 (CHP) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CHP1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHP1 promoter sequence
   Search Chromatin IP Primers for CHP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q13.3   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q13.3

CHP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHP1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P041524:  view genomic region     (about GC identifiers)

Start:
41,523,037 bp from pter      End:
41,574,085 bp from pter
Size:
51,049 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CHP1_HUMAN, Q99653 (See protein sequence)
Recommended Name: Calcineurin B homologous protein 1  
Size: 195 amino acids; 22456 Da
Subunit: Monomer. Interacts with STK17B; the interaction occurs in a calcium-independent manner and induces the
translocation of CHP1 from the Golgi to the nucleus. Interacts with GAPDH; the interaction is direct, occurs in a
N-myristoylation-dependent manner and facilitates the ability of CHP1 to bind microtubules. Interacts with KIF1B
(via C-terminus end of the kinesin-motor domain); the interaction occurs in a calcium-dependent manner.
Associates (via C-terminal domain) with microtubules; the association occurs with polymerized microtubules during
the cell cycle in a myristoylation- and calcium-independent manner and is enhanced by GAPDH (By similarity).
Interacts with PPP3CA. Interacts with SLC9A1/NHE1 (via the juxtamembrane region of the cytoplasmic C-terminus
domain); the interaction occurs at the plasma membrane in a calcium-dependent manner and at a domain that is
critical for growth factor stimulation of the exchanger
1 PDB 3D structure from and Proteopedia for CHP1:
2E30 (3D)    
Secondary accessions: B2R6H9 Q6FHZ9

Explore the universe of human proteins at neXtProt for CHP1: NX_Q99653

Explore proteomics data for CHP1 at MOPED

Post-translational modifications: 

  • Phosphorylated; decreased phosphorylation is associated with an increase in SLC9A1/NHE1 Na(+)/H(+) exchange
    activity. Phosphorylation occurs in serum-dependent manner. The phosphorylation state may regulate the binding to
    SLC9A1/NHE11
  • Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic
    traffic (By similarity). N-myristoylation is required for its association with microtubules and interaction with
    GAPDH, but not for the constitutive association to membranes1
  • Ubiquitination2 at Lys40, Lys182
  • Modification sites at PhosphoSitePlus

  • See CHP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009167.1  
    ENSEMBL proteins: 
     ENSP00000453375   ENSP00000335632   ENSP00000452772   ENSP00000440490   ENSP00000454007  
     ENSP00000453392  
    Reactome Protein details: Q99653

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    2 InterPro protein domains:
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom

    Graphical View of Domain Structure for InterPro Entry Q99653

    ProtoNet protein and cluster: Q99653

    UniProtKB/Swiss-Prot: CHP1_HUMAN, Q99653
    Similarity: Belongs to the calcineurin regulatory subunit family. CHP subfamily
    Similarity: Contains 4 EF-hand domains


    CHP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHP1_HUMAN, Q99653
    Function: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking,
    plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane
    traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum
    and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the
    plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type
    Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic
    pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and
    GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing
    the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to
    the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT
    signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the
    calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the
    apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent
    manner

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004860protein kinase inhibitor activity IEA--
    GO:0005215transporter activity ISS--
    GO:0005509calcium ion binding IDA15035633
    GO:0005515protein binding IPI10593895
    GO:0008017microtubule binding ISS--
         
    CHP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chp1):
     behavior/neurological  nervous system 

    CHP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHP1
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    hsa-mir-16-5p (MIRT031773)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHP1_HUMAN, Q99653: Nucleus (By similarity). Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity).
    Membrane (By similarity). Endoplasmic reticulum-Golgi intermediate compartment (By similarity). Endoplasmic
    reticulum (By similarity). Cell membrane. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes
    in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal
    (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the
    microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with
    membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner.
    Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with
    SLC9A1/NHE1 at the reticulum endoplasmic. Colocalizes with STK17B at the plasma membrane (By similarity).
    Colocalizes with SLC9A1/NHE1 at the cell membrane

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ISS--
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum ISS--
    GO:0005793endoplasmic reticulum-Golgi intermediate compartment IEA--

    CHP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHP1 About    
    See pathways by source

    SuperPathContained pathways About
    1Alzheimer's disease
    Alzheimers Disease0.44
    2Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    Calcium signaling in the CD4+ TCR pathway0.38
    3Role of Calcineurin-dependent NFAT signaling in lymphocytes
    Role of Calcineurin-dependent NFAT signaling in lymphocytes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for CHP1
        Alzheimers Disease
    Calcium signaling in the CD4+ TCR pathway
    Role of Calcineurin-dependent NFAT signaling in lymphocytes


    1 Reactome Pathway for CHP1
        Hyaluronan uptake and degradation



    CHP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHP1
    Interactions:

        Search GeneGlobe Interaction Network for CHP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHP1 (Q996532, 3 ENSP000003356324) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRSS23O950842, 3MINT-63258 I2D: score=5 
    SLC9A1P196343, ENSP000002639804I2D: score=3 STRING: ENSP00000263980
    GAPDHP044063, ENSP000002292394I2D: score=2 STRING: ENSP00000229239
    SLC9A2Q9UBY03, ENSP000002339694I2D: score=2 STRING: ENSP00000233969
    SLC9A3P487643, ENSP000002649384I2D: score=2 STRING: ENSP00000264938
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 26):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001578microtubule bundle formation ISS--
    GO:0001933negative regulation of protein phosphorylation ISS--
    GO:0006469negative regulation of protein kinase activity ISS--
    GO:0006611protein export from nucleus ISS--
    GO:0006813potassium ion transport TAS8901634

    CHP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHP1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHP1 gene: 
    NM_007236.4  

    Unigene Cluster for CHP1:

    Calcineurin-like EF-hand protein 1
    Hs.406234  [show with all ESTs]
    Unigene Representative Sequence: NM_007236
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000558351 ENST00000560411 ENST00000334660(uc001znl.3 uc021sjk.1 uc021sjl.1)
    ENST00000560784 ENST00000561280 ENST00000392151 ENST00000560397 ENST00000560633
    ENST00000560965

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    Additional mRNA sequence: 

    AK299660.1 AK307060.1 AK312582.1 BC008373.1 BC031293.1 BC062538.1 BC073809.1 BC080653.1 
    CR536539.1 CR542085.1 

    13 DOTS entries:

    DT.209631  DT.100754463  DT.100031981  DT.92037426  DT.100038209  DT.100788202  DT.121076996  DT.92027014 
    DT.92473085  DT.92473097  DT.40234227  DT.91843858  DT.99999094 

    10 AceView cDNA sequences:

    BQ945956 NM_007236 CR613629 CR542085 BC031293 CR536539 AK094363 BC008373 
    BC051815 U61538 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHP1 Expression
    About this image


    CHP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Bone marrow-derived hematopoietic stem cells (family)
     
     Limb (Muscoskeletal System)
             Limb Bud
    CHP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406234

    UniProtKB/Swiss-Prot: CHP1_HUMAN, Q99653
    Tissue specificity: Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney,
    thymus and spleen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chp11 , 5 RIKEN cDNA 1500003O03 gene5
    calcineurin-like EF hand protein 11
    92.31(n)1
    98.97(a)1
      2 (59.97 cM)5
    563981  NM_019769.31  NP_062743.11 
     1195476975 
    chicken
    (Gallus gallus)
    Aves CHP11 calcineurin-like EF hand protein 1 84.1(n)
    96.92(a)
      423211  NM_001007930.1  NP_001007931.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHP16
    calcineurin-like EF-hand protein 1
    97(a)
    1 ↔ 1
    1(41764837-41786093)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.62722 Xenopus laevis transcribed sequence with strong similarity more 80.4(n)    BJ030520.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc69b042 wufc69b04 78.16(n)   325361  BC054566.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta elm1 ethanol sensitive with low memory 61.88(n)
    63.3(a)
      40695  NM_001275366.1  NP_001262295.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK856.81 ZK856.8 57.62(n)
    59.04(a)
      179415  NM_073222.3  NP_505623.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CNB16
    Calcineurin B; the regulatory subunit of calcineur...
    39(a)
    1 → many
    XI(82947-83550) YKL190W


    ENSEMBL Gene Tree for CHP1 (if available)
    TreeFam Gene Tree for CHP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHP1 gene
    CIB12  CIB32  PPP3R22  CIB42  PPP3R12  WDR922  ENSG000002733982  CHP22  
    CIB22  
    5 SIMAP similar genes for CHP1 using alignment to 6 protein entries:     CHP1_HUMAN (see all proteins):
    CHP2    HZGJ    PPP3R1    TESC    PPP3R2

    CHP1 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for CHP1
    PGOHUM00000235272 PGOHUM00000243840 PGOHUM00000241203


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHP1 (see all 929)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1156567611,2
    C,F--41524932(+) GCTCTG/CTCTCT 1 -- int11Minor allele frequency- C:0.02WA 118
    rs1837664001,2
    --41524977(+) TAACTC/TACTCC 1 -- int10--------
    rs1506507461,2
    --41525029(+) ACAGAA/GTTTTT 1 -- int10--------
    rs1387676341,2
    C--41525102(+) TGGAA-/GGGATG 1 -- int10--------
    rs1419880791,2
    --41525172(+) GCCCTC/TAAGCC 1 -- int10--------
    rs1161867851,2
    F--41525211(+) CCTCTC/TCACCT 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1874087981,2
    --41525267(+) CTCTTC/TATAAT 1 -- int10--------
    rs1463810641,2
    --41525324(+) AGACGC/GAAGCA 1 -- int10--------
    rs1397587301,2
    C--41525341(+) ATTCAA/GCAAGC 1 -- int10--------
    rs414421441,2
    C,F,H--41525357(-) CAAAAC/TGTAAT 1 -- int122Minor allele frequency- T:0.35NS EA NA WA CSA 2125

    HapMap Linkage Disequilibrium report for CHP1 (41523037 - 41574085 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CHP1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHP1
    DNA2.0 Custom Variant and Variant Library Synthesis for CHP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606988    OMIM disorders: --

    8 diseases for CHP1:    
    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis    parkinson's disease    inflammatory bowel disease
    schizophrenia    tuberculosis    alzheimer's disease    malaria


    CHP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for CHP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHP1 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with CHP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis. (PubMed id 20720019)1, 2, 3 Jimenez-Vidal M.... Barber D.L. (J. Biol. Chem. 2010)
    2. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. (PubMed id 8901634)1, 2, 9 Lin X. and Barber D.L. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1. (PubMed id 17050540)1, 2 Mishima M.... Kojima C. (J. Biol. Chem. 2007)
    4. Structural characterization of calcineurin B homologous protein 1. (PubMed id 15987692)1, 3 Naoe Y....Shimizu T. (J. Biol. Chem. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements. (PubMed id 15035633)1, 2 Pang T.... Wakabayashi S. (Biochemistry 2004)
    8. Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. (PubMed id 11350981)1, 2 Pang T.... Shigekawa M. (J. Biol. Chem. 2001)
    9. Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein. (PubMed id 10593895)1, 2 Lin X.... Barber D.L. (J. Biol. Chem. 1999)
    10. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. (PubMed id 11481038)1, 9 Matsumoto M....Kanazawa H. (J. Biochem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11261 HGNC: 17433 AceView: CHP Ensembl:ENSG00000187446 euGenes: HUgn11261
    ECgene: CHP1 H-InvDB: CHP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CHP1 gene:
    Search GeneIP for patents involving CHP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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