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Aliases for CHP1 Gene

Aliases for CHP1 Gene

  • Calcineurin-Like EF-Hand Protein 1 2 3
  • CHP 3 4 6
  • EF-Hand Calcium-Binding Domain-Containing Protein P22 3 4
  • Calcineurin Homologous Protein 2 3
  • Calcium-Binding Protein CHP 3 4
  • Calcium-Binding Protein P22 3 4
  • Calcineurin B-Like Protein 3 4
  • Calcineurin B Homologous Protein 1 3
  • Calcineurin-Like EF Hand Protein 1 3
  • Calcium Binding Protein P22 3
  • SLC9A1 Binding Protein 3
  • Calcineurin B Homolog 3
  • SLC9A1BP 3
  • Sid470p 3
  • P24 3
  • P22 3

External Ids for CHP1 Gene

Summaries for CHP1 Gene

Entrez Gene Summary for CHP1 Gene

  • This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHP1 Gene

CHP1 (Calcineurin-Like EF-Hand Protein 1) is a Protein Coding gene. Among its related pathways are Alzheimers disease and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include calcium ion binding and microtubule binding. An important paralog of this gene is PPP3R2.

UniProtKB/Swiss-Prot for CHP1 Gene

  • Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

Gene Wiki entry for CHP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHP1 Gene

Genomics for CHP1 Gene

Genomic Location for CHP1 Gene

Start:
41,230,839 bp from pter
End:
41,281,890 bp from pter
Size:
51,052 bases
Orientation:
Plus strand

Genomic View for CHP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHP1 Gene

No data available for Regulatory Elements for CHP1 Gene

Proteins for CHP1 Gene

  • Protein details for CHP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99653-CHP1_HUMAN
    Recommended name:
    Calcineurin B homologous protein 1
    Protein Accession:
    Q99653
    Secondary Accessions:
    • B2R6H9
    • Q6FHZ9

    Protein attributes for CHP1 Gene

    Size:
    195 amino acids
    Molecular mass:
    22456 Da
    Quaternary structure:
    • Monomer. Interacts with STK17B; the interaction occurs in a calcium-independent manner and induces the translocation of CHP1 from the Golgi to the nucleus. Interacts with GAPDH; the interaction is direct, occurs in a N-myristoylation-dependent manner and facilitates the ability of CHP1 to bind microtubules. Interacts with KIF1B (via the C-terminal end of the kinesin-motor domain); the interaction occurs in a calcium-dependent manner. Associates (via C-terminal domain) with microtubules; the association occurs with polymerized microtubules during the cell cycle in a myristoylation- and calcium-independent manner and is enhanced by GAPDH (By similarity). Interacts with PPP3CA. Interacts with SLC9A1/NHE1 (via the juxtamembrane region of the cytoplasmic C-terminal domain); the interaction occurs at the plasma membrane in a calcium-dependent manner and at a domain that is critical for growth factor stimulation of the exchanger.

    Three dimensional structures from OCA and Proteopedia for CHP1 Gene

neXtProt entry for CHP1 Gene

Proteomics data for CHP1 Gene at MOPED

Post-translational modifications for CHP1 Gene

  • Both N-myristoylation and calcium-mediated conformational changes are essential for its function in exocytic traffic (By similarity). N-myristoylation is required for its association with microtubules and interaction with GAPDH, but not for the constitutive association to membranes.
  • Phosphorylated; decreased phosphorylation is associated with an increase in SLC9A1/NHE1 Na(+)/H(+) exchange activity. Phosphorylation occurs in serum-dependent manner. The phosphorylation state may regulate the binding to SLC9A1/NHE1.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys40 and Lys182

Other Protein References for CHP1 Gene

No data available for DME Specific Peptides for CHP1 Gene

Domains for CHP1 Gene

Gene Families for CHP1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CHP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CHP1_HUMAN
Domain:
  • Contains 4 EF-hand domains.:
    • Q99653
Family:
  • Belongs to the calcineurin regulatory subunit family. CHP subfamily.:
    • Q99653
genes like me logo Genes that share domains with CHP1: view

Function for CHP1 Gene

Molecular function for CHP1 Gene

UniProtKB/Swiss-Prot Function: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

Gene Ontology (GO) - Molecular Function for CHP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IEA --
GO:0005215 transporter activity ISS --
GO:0005509 calcium ion binding IDA 15035633
GO:0005515 protein binding IPI 10593895
GO:0008017 microtubule binding ISS --
genes like me logo Genes that share ontologies with CHP1: view

Phenotypes for CHP1 Gene

genes like me logo Genes that share phenotypes with CHP1: view

miRNA for CHP1 Gene

miRTarBase miRNAs that target CHP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHP1 Gene

Localization for CHP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHP1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Membrane. Endoplasmic reticulum-Golgi intermediate compartment. Endoplasmic reticulum. Cell membrane. Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1/NHE1 at the reticulum endoplasmic. Colocalizes with STK17B at the plasma membrane (By similarity). Colocalizes with SLC9A1/NHE1 at the cell membrane. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for CHP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane ISS --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
GO:0005783 endoplasmic reticulum ISS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
genes like me logo Genes that share ontologies with CHP1: view

Pathways for CHP1 Gene

genes like me logo Genes that share pathways with CHP1: view

Gene Ontology (GO) - Biological Process for CHP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation ISS --
GO:0001933 negative regulation of protein phosphorylation ISS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006469 negative regulation of protein kinase activity ISS --
GO:0006611 protein export from nucleus ISS --
genes like me logo Genes that share ontologies with CHP1: view

Transcripts for CHP1 Gene

mRNA/cDNA for CHP1 Gene

(2) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CHP1 Gene

No ASD Table

Relevant External Links for CHP1 Gene

GeneLoc Exon Structure for
CHP1
ECgene alternative splicing isoforms for
CHP1

Expression for CHP1 Gene

mRNA expression in normal human tissues for CHP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHP1 Gene

SOURCE GeneReport for Unigene cluster for CHP1 Gene Hs.406234

mRNA Expression by UniProt/SwissProt for CHP1 Gene

Q99653-CHP1_HUMAN
Tissue specificity: Ubiquitously expressed. Has been found in fetal eye, lung, liver, muscle, heart, kidney, thymus and spleen.
genes like me logo Genes that share expressions with CHP1: view

Orthologs for CHP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHP1 36
  • 100 (n)
  • 100 (a)
CHP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHP1 36
  • 95.56 (n)
  • 99.49 (a)
CHP1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHP1 36
  • 94.87 (n)
  • 99.49 (a)
CHP1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chp1 36
  • 92.31 (n)
  • 98.97 (a)
Chp1 16
Chp1 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHP1 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHP1 37
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chp1 36
  • 93.68 (n)
  • 98.97 (a)
chicken
(Gallus gallus)
Aves CHP1 36
  • 84.1 (n)
  • 96.92 (a)
CHP1 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHP1 37
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6272 36
tropical clawed frog
(Silurana tropicalis)
Amphibia chp1 36
  • 79.27 (n)
  • 95.34 (a)
Str.11512 36
zebrafish
(Danio rerio)
Actinopterygii chp1 36
  • 77.32 (n)
  • 89.69 (a)
chp1 37
  • 90 (a)
OneToOne
wufc69b04 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001760 36
  • 60.64 (n)
  • 63.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta elm 36
  • 61.88 (n)
  • 63.3 (a)
elm 37
  • 62 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F59D6.7 37
  • 53 (a)
ManyToMany
pbo-1 37
  • 49 (a)
ManyToMany
ZK856.8 36
  • 57.62 (n)
  • 59.04 (a)
ZK856.8 37
  • 56 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CNB1 37
  • 39 (a)
OneToMany
Species with no ortholog for CHP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHP1 Gene

ENSEMBL:
Gene Tree for CHP1 (if available)
TreeFam:
Gene Tree for CHP1 (if available)

Paralogs for CHP1 Gene

Paralogs for CHP1 Gene

Selected SIMAP similar genes for CHP1 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CHP1 Gene

genes like me logo Genes that share paralogs with CHP1: view

Variants for CHP1 Gene

Sequence variations from dbSNP and Humsavar for CHP1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs9568 -- 41,281,414(+) GACTT(A/C)AGTGA utr-variant-3-prime
rs1138527 -- 41,281,816(+) AATCC(A/C)CGGTT utr-variant-3-prime
rs1866399 -- 41,278,941(-) gccac(C/T)gcgcc intron-variant
rs1965139 -- 41,244,154(-) GTGGC(A/G)TGATC intron-variant
rs1965140 -- 41,244,067(-) GCGCC(C/T)ACCAC intron-variant

Relevant External Links for CHP1 Gene

HapMap Linkage Disequilibrium report
CHP1

No data available for Structural Variations from Database of Genomic Variants (DGV) for CHP1 Gene

Disorders for CHP1 Gene

No disorders were found for CHP1 Gene.

No data available for UniProtKB/Swiss-Prot for CHP1 Gene

Publications for CHP1 Gene

  1. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. (PMID: 8901634) Lin X. … Barber D.L. (Proc. Natl. Acad. Sci. U.S.A. 1996) 3 4 23
  2. Nuclear-localized calcineurin homologous protein CHP1 interacts with upstream binding factor and inhibits ribosomal RNA synthesis. (PMID: 20720019) Jimenez-Vidal M. … Barber D.L. (J. Biol. Chem. 2010) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements. (PMID: 15035633) Pang T. … Wakabayashi S. (Biochemistry 2004) 3 4
  5. A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger. (PMID: 11481038) Matsumoto M. … Kanazawa H. (J. Biochem. 2001) 3 23

Products for CHP1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CHP1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CHP1
    • Block miRNA regulation of CHP1 using miScript Target Protectors

    Sources for CHP1 Gene

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