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Aliases for CHORDC1 Gene

Aliases for CHORDC1 Gene

  • Cysteine And Histidine Rich Domain Containing 1 2 3 5
  • Cysteine And Histidine-Rich Domain (CHORD)-Containing, Zinc-Binding Protein 1 2 3
  • CHORD-Containing Protein 1 3 4
  • Protein Morgana 3 4
  • Morgana 2 3
  • CHP-1 3 4
  • CHP1 3 4
  • Cysteine And Histidine-Rich Domain (CHORD) Containing 1 3
  • Cysteine And Histidine-Rich Domain-Containing Protein 1 3
  • Chord Domain-Containing Protein 1 3
  • CHORD Domain-Containing Protein 1 4

External Ids for CHORDC1 Gene

Previous GeneCards Identifiers for CHORDC1 Gene

  • GC11M092263
  • GC11M091440
  • GC11M090118
  • GC11M089622
  • GC11M089574
  • GC11M089933
  • GC11M086018

Summaries for CHORDC1 Gene

GeneCards Summary for CHORDC1 Gene

CHORDC1 (Cysteine And Histidine Rich Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include Hsp90 protein binding. An important paralog of this gene is ITGB1BP2.

UniProtKB/Swiss-Prot for CHORDC1 Gene

  • Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.

Additional gene information for CHORDC1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHORDC1 Gene

Genomics for CHORDC1 Gene

Regulatory Elements for CHORDC1 Gene

Enhancers for CHORDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H090251 0.7 ENCODE 11.2 -27.8 -27784 0 ELF3 TBP DRAP1 SAP130 ARID4B DMAP1 MNT KAT8 POLR2A GATAD1 CHORDC1 TRIM49C DISC1FP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHORDC1 on UCSC Golden Path with GeneCards custom track

Promoters for CHORDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000043257 664 2601 ATF1 FOXA2 ARID4B SIN3A DMAP1 YY1 GLIS2 ELK1 RUNX3 MXD4

Genomic Location for CHORDC1 Gene

Chromosome:
11
Start:
90,193,947 bp from pter
End:
90,223,364 bp from pter
Size:
29,418 bases
Orientation:
Minus strand

Genomic View for CHORDC1 Gene

Genes around CHORDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHORDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHORDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHORDC1 Gene

Proteins for CHORDC1 Gene

  • Protein details for CHORDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHD1-CHRD1_HUMAN
    Recommended name:
    Cysteine and histidine-rich domain-containing protein 1
    Protein Accession:
    Q9UHD1
    Secondary Accessions:
    • B2R6P8
    • Q6IN49
    • Q8WVL9
    • Q9H3D6

    Protein attributes for CHORDC1 Gene

    Size:
    332 amino acids
    Molecular mass:
    37490 Da
    Quaternary structure:
    • Interacts with HSP90AA1, ROCK1 and ROCK2. Interacts with HSP90AB1 and PPP5C (By similarity).
    SequenceCaution:
    • Sequence=AAH17789.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHORDC1 Gene

    Alternative splice isoforms for CHORDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHORDC1 Gene

Post-translational modifications for CHORDC1 Gene

  • Ubiquitination at posLast=9191 and posLast=289289
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CHORDC1 Gene

Domains & Families for CHORDC1 Gene

Gene Families for CHORDC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CHORDC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHORDC1: view

No data available for UniProtKB/Swiss-Prot for CHORDC1 Gene

Function for CHORDC1 Gene

Molecular function for CHORDC1 Gene

UniProtKB/Swiss-Prot Function:
Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.

Phenotypes From GWAS Catalog for CHORDC1 Gene

Gene Ontology (GO) - Molecular Function for CHORDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19875381
GO:0005524 ATP binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0043531 ADP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CHORDC1: view
genes like me logo Genes that share phenotypes with CHORDC1: view

Animal Models for CHORDC1 Gene

MGI Knock Outs for CHORDC1:

Animal Model Products

CRISPR Products

miRNA for CHORDC1 Gene

miRTarBase miRNAs that target CHORDC1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHORDC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHORDC1 Gene

Localization for CHORDC1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHORDC1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHORDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CHORDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CHORDC1 Gene

Pathways & Interactions for CHORDC1 Gene

SuperPathways for CHORDC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHORDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010824 regulation of centrosome duplication IEA --
GO:0061077 chaperone-mediated protein folding ISS --
GO:1900034 regulation of cellular response to heat ISS --
GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with CHORDC1: view

No data available for Pathways by source and SIGNOR curated interactions for CHORDC1 Gene

Drugs & Compounds for CHORDC1 Gene

No Compound Related Data Available

Transcripts for CHORDC1 Gene

Unigene Clusters for CHORDC1 Gene

Cysteine and histidine-rich domain (CHORD) containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHORDC1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CHORDC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:
SP6: -

Relevant External Links for CHORDC1 Gene

GeneLoc Exon Structure for
CHORDC1
ECgene alternative splicing isoforms for
CHORDC1

Expression for CHORDC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHORDC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CHORDC1 Gene

This gene is overexpressed in Heart (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHORDC1 Gene



Protein tissue co-expression partners for CHORDC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHORDC1 Gene:

CHORDC1

SOURCE GeneReport for Unigene cluster for CHORDC1 Gene:

Hs.22857

mRNA Expression by UniProt/SwissProt for CHORDC1 Gene:

Q9UHD1-CHRD1_HUMAN
Tissue specificity: Underexpressed in many breast and lung cancers.

Evidence on tissue expression from TISSUES for CHORDC1 Gene

  • Nervous system(4.9)
  • Heart(4.2)
  • Liver(2.1)
  • Lung(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CHORDC1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHORDC1 Gene

Orthologs for CHORDC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHORDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHORDC1 33 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia CHORDC1 33 34
  • 93.85 (n)
dog
(Canis familiaris)
Mammalia CHORDC1 33 34
  • 93.46 (n)
mouse
(Mus musculus)
Mammalia Chordc1 33 16 34
  • 91.26 (n)
rat
(Rattus norvegicus)
Mammalia Chordc1 33
  • 91.26 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 86 (a)
OneToMany
-- 34
  • 85 (a)
OneToMany
-- 34
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CHORDC1 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHORDC1 33 34
  • 80.28 (n)
lizard
(Anolis carolinensis)
Reptilia CHORDC1 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chordc1 33
  • 74.11 (n)
Str.20211 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13687 33
zebrafish
(Danio rerio)
Actinopterygii chordc1b 33 34
  • 68.99 (n)
chordc1a 34
  • 65 (a)
OneToMany
zgc63894 33
fruit fly
(Drosophila melanogaster)
Insecta CHORD 35 33 34
  • 53.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003064 33
  • 51.42 (n)
worm
(Caenorhabditis elegans)
Secernentea chp-1 35 33 34
  • 53.4 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBS2 33
  • 47.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4939 34
  • 45 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03087 33
  • 44.27 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4117 33
Species where no ortholog for CHORDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHORDC1 Gene

ENSEMBL:
Gene Tree for CHORDC1 (if available)
TreeFam:
Gene Tree for CHORDC1 (if available)

Paralogs for CHORDC1 Gene

Paralogs for CHORDC1 Gene

(1) SIMAP similar genes for CHORDC1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CHORDC1: view

Variants for CHORDC1 Gene

Sequence variations from dbSNP and Humsavar for CHORDC1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000180018 -- 90,215,389(+) TAAAA(C/T)GAATA intron-variant
rs1000457412 -- 90,204,931(+) AAGTA(C/G)GAAAT intron-variant
rs1000583966 -- 90,216,900(+) AAGGT(C/T)ACCTT intron-variant
rs1000623950 -- 90,222,153(+) CTAAT(A/T)GTCAT intron-variant
rs1000663717 -- 90,222,499(+) CTACT(C/T)CGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHORDC1 Gene

Variant ID Type Subtype PubMed ID
dgv2083n54 CNV gain 21841781
esv3579841 CNV loss 25503493
esv3579993 CNV gain 25503493
nsv1035213 CNV gain 25217958
nsv1048042 CNV loss 25217958
nsv1048624 CNV loss 25217958
nsv468787 CNV loss 19166990
nsv480345 CNV novel sequence insertion 20440878
nsv555830 CNV loss 21841781
nsv555832 CNV gain 21841781
nsv555833 CNV loss 21841781
nsv975965 CNV duplication 23825009

Variation tolerance for CHORDC1 Gene

Residual Variation Intolerance Score: 48.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.45; 9.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHORDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHORDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHORDC1 Gene

Disorders for CHORDC1 Gene

Relevant External Links for CHORDC1

Genetic Association Database (GAD)
CHORDC1
Human Genome Epidemiology (HuGE) Navigator
CHORDC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHORDC1

No disorders were found for CHORDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHORDC1 Gene

Publications for CHORDC1 Gene

  1. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans. (PMID: 10571178) Shirasu K … Schulze-Lefert P (Cell 1999) 2 3 4 60
  2. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PMID: 19875381) Gano JJ … Simon JA (Molecular & cellular proteomics : MCP 2010) 3 4 60
  3. Morgana/chp-1, a ROCK inhibitor involved in centrosome duplication and tumorigenesis. (PMID: 20230755) Ferretti R … Brancaccio M (Developmental cell 2010) 3 4 60
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 45 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for CHORDC1 Gene

Sources for CHORDC1 Gene

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