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Aliases for CHORDC1 Gene

Aliases for CHORDC1 Gene

  • Cysteine And Histidine-Rich Domain (CHORD) Containing 1 2 3
  • Cysteine And Histidine-Rich Domain (CHORD)-Containing, Zinc-Binding Protein 1 2 3
  • Cysteine And Histidine-Rich Domain (CHORD)-Containing 1 2 3
  • CHORD-Containing Protein 1 3 4
  • Protein Morgana 3 4
  • CHP-1 3 4
  • CHP1 3 4
  • Cysteine And Histidine-Rich Domain-Containing Protein 1 3
  • Chord Domain-Containing Protein 1 3
  • CHORD Domain-Containing Protein 1 4

External Ids for CHORDC1 Gene

Summaries for CHORDC1 Gene

GeneCards Summary for CHORDC1 Gene

CHORDC1 (Cysteine And Histidine-Rich Domain (CHORD) Containing 1) is a Protein Coding gene. Diseases associated with CHORDC1 include inclusion conjunctivitis. Among its related pathways are Alzheimers disease and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. GO annotations related to this gene include Hsp90 protein binding. An important paralog of this gene is ITGB1BP2.

UniProtKB/Swiss-Prot for CHORDC1 Gene

  • Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHORDC1 Gene

Genomics for CHORDC1 Gene

Genomic Location for CHORDC1 Gene

Start:
90,200,429 bp from pter
End:
90,223,364 bp from pter
Size:
22,936 bases
Orientation:
Minus strand

Genomic View for CHORDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHORDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHORDC1 Gene

Regulatory Elements for CHORDC1 Gene

Proteins for CHORDC1 Gene

  • Protein details for CHORDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHD1-CHRD1_HUMAN
    Recommended name:
    Cysteine and histidine-rich domain-containing protein 1
    Protein Accession:
    Q9UHD1
    Secondary Accessions:
    • B2R6P8
    • Q6IN49
    • Q8WVL9
    • Q9H3D6

    Protein attributes for CHORDC1 Gene

    Size:
    332 amino acids
    Molecular mass:
    37490 Da
    Quaternary structure:
    • Interacts with HSP90AA1, ROCK1 and ROCK2. Interacts with HSP90AB1 and PPP5C (By similarity).
    SequenceCaution:
    • Sequence=AAH17789.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHORDC1 Gene

    Alternative splice isoforms for CHORDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHORDC1 Gene

Proteomics data for CHORDC1 Gene at MOPED

Post-translational modifications for CHORDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys91 and Lys289

No data available for DME Specific Peptides for CHORDC1 Gene

Domains for CHORDC1 Gene

Protein Domains for CHORDC1 Gene

UniProtKB/Swiss-Prot:

CHRD1_HUMAN
Domain:
  • Contains 2 CHORD domains.:
    • Q9UHD1
  • Contains 1 CS domain.:
    • Q9UHD1
genes like me logo Genes that share domains with CHORDC1: view

No data available for Gene Families for CHORDC1 Gene

Function for CHORDC1 Gene

Molecular function for CHORDC1 Gene

UniProtKB/Swiss-Prot Function: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis.

Gene Ontology (GO) - Molecular Function for CHORDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19875381
GO:0008270 zinc ion binding IEA --
GO:0051879 Hsp90 protein binding IPI 19875381
genes like me logo Genes that share ontologies with CHORDC1: view
genes like me logo Genes that share phenotypes with CHORDC1: view

miRNA for CHORDC1 Gene

miRTarBase miRNAs that target CHORDC1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHORDC1 Gene

Localization for CHORDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHORDC1 Gene COMPARTMENTS Subcellular localization image for CHORDC1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHORDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CHORDC1: view

Pathways for CHORDC1 Gene

genes like me logo Genes that share pathways with CHORDC1: view

Pathways by source for CHORDC1 Gene

Gene Ontology (GO) - Biological Process for CHORDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress --
GO:0010824 regulation of centrosome duplication IEA --
GO:0061077 chaperone-mediated protein folding ISS --
GO:1900034 regulation of cellular response to heat ISS --
GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with CHORDC1: view

Transcripts for CHORDC1 Gene

Unigene Clusters for CHORDC1 Gene

Cysteine and histidine-rich domain (CHORD) containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHORDC1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5:
SP6: -

Relevant External Links for CHORDC1 Gene

GeneLoc Exon Structure for
CHORDC1
ECgene alternative splicing isoforms for
CHORDC1

Expression for CHORDC1 Gene

mRNA expression in normal human tissues for CHORDC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHORDC1 Gene

SOURCE GeneReport for Unigene cluster for CHORDC1 Gene Hs.22857

mRNA Expression by UniProt/SwissProt for CHORDC1 Gene

Q9UHD1-CHRD1_HUMAN
Tissue specificity: Underexpressed in many breast and lung cancers.
genes like me logo Genes that share expressions with CHORDC1: view

Orthologs for CHORDC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHORDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHORDC1 36
  • 99.6 (n)
  • 99.4 (a)
CHORDC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHORDC1 36
  • 93.85 (n)
  • 97.5 (a)
CHORDC1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHORDC1 36
  • 93.46 (n)
  • 96.01 (a)
CHORDC1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chordc1 36
  • 91.26 (n)
  • 96.34 (a)
Chordc1 16
Chordc1 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHORDC1 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 80 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Chordc1 36
  • 91.26 (n)
  • 96.34 (a)
chicken
(Gallus gallus)
Aves CHORDC1 36
  • 80.28 (n)
  • 85.37 (a)
CHORDC1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHORDC1 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13687 36
tropical clawed frog
(Silurana tropicalis)
Amphibia chordc1 36
  • 74.11 (n)
  • 83.04 (a)
Str.20211 36
zebrafish
(Danio rerio)
Actinopterygii chordc1a 37
  • 65 (a)
OneToMany
chordc1b 36
  • 68.99 (n)
  • 72.73 (a)
chordc1b 37
  • 71 (a)
OneToMany
zgc63894 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003064 36
  • 51.42 (n)
  • 46.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CHORD 36
  • 53.16 (n)
  • 46.18 (a)
CHORD 37
  • 39 (a)
OneToMany
CHORD 38
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea chp-1 36
  • 53.4 (n)
  • 38.46 (a)
chp-1 37
  • 33 (a)
OneToMany
chp-1 38
  • 35 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PBS2 36
  • 47.52 (n)
  • 36.92 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03087 36
  • 44.27 (n)
  • 37.45 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4117 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4939 37
  • 45 (a)
OneToMany
Species with no ortholog for CHORDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHORDC1 Gene

ENSEMBL:
Gene Tree for CHORDC1 (if available)
TreeFam:
Gene Tree for CHORDC1 (if available)

Paralogs for CHORDC1 Gene

Paralogs for CHORDC1 Gene

Selected SIMAP similar genes for CHORDC1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CHORDC1: view

Variants for CHORDC1 Gene

Sequence variations from dbSNP and Humsavar for CHORDC1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs492848 -- 90,205,829(-) CCATA(C/T)TTTTC intron-variant
rs523216 -- 90,219,023(-) ctccc(A/C)aagtg intron-variant
rs562057 -- 90,218,159(-) GGTGT(C/T)CCGGT synonymous-codon, reference, nc-transcript-variant
rs562165 -- 90,218,123(-) ACTAT(A/T)TTTTC intron-variant
rs723715 -- 90,206,401(+) ATTCA(C/T)AAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHORDC1 Gene

Variant ID Type Subtype PubMed ID
nsv898142 CNV Gain 21882294
nsv468787 CNV Loss 19166990

Relevant External Links for CHORDC1 Gene

HapMap Linkage Disequilibrium report
CHORDC1

Disorders for CHORDC1 Gene

(1) MalaCards Diseases for CHORDC1 Gene

Search for CHORDC1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CHORDC1 Gene

Relevant External Links for CHORDC1

Genetic Association Database (GAD)
CHORDC1
Human Genome Epidemiology (HuGE) Navigator
CHORDC1
genes like me logo Genes that share disorders with CHORDC1: view

No data available for UniProtKB/Swiss-Prot for CHORDC1 Gene

Publications for CHORDC1 Gene

  1. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans. (PMID: 10571178) Shirasu K. … Schulze-Lefert P. (Cell 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PMID: 19875381) Gano J.J. … Simon J.A. (Mol. Cell. Proteomics 2010) 3 4
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for CHORDC1 Gene

Sources for CHORDC1 Gene

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