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CHORDC1 Gene

protein-coding   GIFtS: 55
GCID: GC11M089933

Cysteine And Histidine-Rich Domain (CHORD) Containing 1

(Previous names: cysteine and histidine-rich domain (CHORD)-containing, zinc-binding...)
  See CHORDC1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine And Histidine-Rich Domain (CHORD) Containing 11 2     CHP-12 3
Cysteine And Histidine-Rich Domain (CHORD)-Containing 11 2     CHP12 3
Cysteine And Histidine-Rich Domain (CHORD)-Containing, Zinc-Binding
Protein 11 2
     CHORD-Containing Protein 12 3
CHORD Domain-Containing Protein 12 3     Cysteine And Histidine-Rich Domain-Containing Protein 12
Protein Morgana2 3     

External Ids:    HGNC: 145251   Entrez Gene: 269732   Ensembl: ENSG000001101727   OMIM: 6043535   UniProtKB: Q9UHD13   

Export aliases for CHORDC1 gene to outside databases

Previous GC identifers: GC11M092263 GC11M091440 GC11M090118 GC11M089622 GC11M089574 GC11M086018


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CHORDC1 Gene:
CHORDC1 (cysteine and histidine-rich domain (CHORD) containing 1) is a protein-coding gene. Diseases associated with CHORDC1 include inclusion conjunctivitis. GO annotations related to this gene include Hsp90 protein binding. An important paralog of this gene is ITGB1BP2.

UniProtKB/Swiss-Prot: CHRD1_HUMAN, Q9UHD1
Function: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act
as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has
intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1.
Involved in stress response. Prevents tumorigenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHORDC1 gene promoter:
         AREB6   TBP   LHX3b/Lhx3b   Brachyury   Zic1   LHX3a/Lhx3a   IRF-1   c-Ets-1   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHORDC1 promoter sequence
   Search Chromatin IP Primers for CHORDC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHORDC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q14.3

CHORDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHORDC1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M089933:  view genomic region     (about GC identifiers)

Start:
89,933,597 bp from pter      End:
89,956,532 bp from pter
Size:
22,936 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CHRD1_HUMAN, Q9UHD1 (See protein sequence)
Recommended Name: Cysteine and histidine-rich domain-containing protein 1  
Size: 332 amino acids; 37490 Da
Subunit: Interacts with HSP90AA1, ROCK1 and ROCK2. Interacts with HSP90AB1 and PPP5C (By similarity)
Sequence caution: Sequence=AAH17789.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for CHORDC1:
2YRT (3D)    
Secondary accessions: B2R6P8 Q6IN49 Q8WVL9 Q9H3D6
Alternative splicing: 2 isoforms:  Q9UHD1-1   Q9UHD1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHORDC1: NX_Q9UHD1

Explore proteomics data for CHORDC1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys91, Lys289
  • Modification sites at PhosphoSitePlus

  • See CHORDC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001137545.1  NP_036256.2  

    ENSEMBL proteins: 
     ENSP00000319255   ENSP00000433719   ENSP00000401080   ENSP00000436632   ENSP00000436945  
     ENSP00000434040   ENSP00000431929   ENSP00000433440   ENSP00000432019  

    CHORDC1 Human Recombinant Protein Products:

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    Novus Biologicals CHORDC1 Proteins
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    Cloud-Clone Corp. Proteins for CHORDC1

     
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    antibodies-online proteins for CHORDC1 (9 products) 

     
    antibodies-online peptides for CHORDC1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR007051 CHORD
     IPR008978 HSP20-like_chaperone
     IPR007052 CS_dom

    Graphical View of Domain Structure for InterPro Entry Q9UHD1

    ProtoNet protein and cluster: Q9UHD1

    2 Blocks protein domains:
    IPB007052 CS domain
    IPB011070 Globular protein


    UniProtKB/Swiss-Prot: CHRD1_HUMAN, Q9UHD1
    Similarity: Contains 2 CHORD domains
    Similarity: Contains 1 CS domain


    Find genes that share domains with CHORDC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHRD1_HUMAN, Q9UHD1
    Function: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act
    as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has
    intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1.
    Involved in stress response. Prevents tumorigenesis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19875381
    GO:0008270zinc ion binding IEA--
    GO:0051879Hsp90 protein binding IPI19875381
         
    Find genes that share ontologies with CHORDC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CHORDC1:
     Increased number of cells in m 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chordc1):
     cellular  embryogenesis  homeostasis/metabolism  mortality/aging  tumorigenesis 

    Find genes that share phenotypes with CHORDC1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CHORDC1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHORDC1:
    hsa-mir-26b-5p (MIRT029651), hsa-mir-16-5p (MIRT001472)

    Block miRNA regulation of human, mouse, rat CHORDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHORDC1 (see all 31):
    hsa-miR-21* hsa-miR-30c hsa-miR-498 hsa-miR-137 hsa-miR-539 hsa-miR-15a hsa-miR-30d hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidCHORDC1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CHORDC1

    Gene Editing
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    Find genes that share ontologies with CHORDC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHORDC1
    Interactions:

        GeneGlobe Interaction Network for CHORDC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CHORDC1 (Q9UHD11, 3 ENSP000003192554) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSP90AA1P079001, 3, ENSP000003351534EBI-2550959,EBI-296047 I2D: score=2 STRING: ENSP00000335153
    HSP90AB1P082383, ENSP000003258754I2D: score=2 STRING: ENSP00000325875
    PPP5CP530413, ENSP000000124434I2D: score=2 STRING: ENSP00000012443
    RALAP112333I2D: score=3 
    NUDT21O438093I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress IEA--
    GO:0010824regulation of centrosome duplication IEA--
    GO:0061077chaperone-mediated protein folding ISS--
    GO:0080134regulation of response to stress ----
    GO:1900034regulation of cellular response to heat ISS--

    Find genes that share ontologies with CHORDC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHORDC1 (CHRD1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHORDC1 gene (2 alternative transcripts): 
    NM_001144073.1  NM_012124.2  

    Unigene Cluster for CHORDC1:

    Cysteine and histidine-rich domain (CHORD) containing 1
    Hs.22857  [show with all ESTs]
    Unigene Representative Sequence: BX537692
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320585(uc001pdg.2 uc009yvz.2) ENST00000529987 ENST00000533724
    ENST00000457199 ENST00000529726 ENST00000525317 ENST00000533772 ENST00000530765
    ENST00000533062 ENST00000529402 ENST00000533739
    miRNA
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    Block miRNA regulation of human, mouse, rat CHORDC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHORDC1 (see all 31):
    hsa-miR-21* hsa-miR-30c hsa-miR-498 hsa-miR-137 hsa-miR-539 hsa-miR-15a hsa-miR-30d hsa-miR-944
    SwitchGear 3'UTR luciferase reporter plasmidCHORDC1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CHORDC1 (NM_012124)
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    Primer
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    OriGene qPCR primer pairs and template standards for CHORDC1
    OriGene qSTAR qPCR primer pairs in human, mouse for CHORDC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHORDC1
      QuantiTect SYBR Green Assays in human, mouse, rat CHORDC1
      QuantiFast Probe-based Assays in human, mouse, rat CHORDC1

    Additional mRNA sequence: 

    AF123249.1 AF192466.1 AK225365.1 AK225565.1 AK290231.1 AK312663.1 BC002339.2 BC017789.1 
    BC072461.1 BX537692.1 

    14 DOTS entries:

    DT.212364  DT.75100375  DT.91909487  DT.99968682  DT.95173639  DT.406672  DT.95135466  DT.120736359 
    DT.65286738  DT.95339679  DT.99985816  DT.120736365  DT.120943080  DT.95173636 

    Selected AceView cDNA sequences (see all 205):

    BM505514 BC002339 AW169472 BX421616 CD691649 BI963949 AL600010 BE906737 
    BM457418 BI829279 BQ959658 AF123249 AI571118 AA774592 CD676544 BG110863 
    AI633070 BM834924 BQ214961 AA738116 BX443493 CA423239 BC017789 CR623645 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHORDC1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                          -                             -     -                       -                           
    SP2:                          -                             -     -                                                   
    SP3:                          -                             -     -                                                   
    SP4:                          -                             -                                                         
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for CHORDC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHORDC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHORDC1 Expression
    About this image

    CHORDC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHORDC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.22857

    UniProtKB/Swiss-Prot: CHRD1_HUMAN, Q9UHD1
    Tissue specificity: Underexpressed in many breast and lung cancers

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHORDC1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chordc11 , 5 cysteine and histidine-rich domain (CHORD)-containing, more1, 5 91.26(n)1
    96.34(a)1
      9 (7.01 cM)5
    669171  NM_025844.21  NP_080120.11 
     182922675 
    chicken
    (Gallus gallus)
    Aves CHORDC11 cysteine and histidine-rich domain (CHORD) containing more 80.28(n)
    85.37(a)
      419009  NM_001030832.1  NP_001026003.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHORDC16
    cysteine and histidine-rich domain (CHORD) contain...
    79(a)
    1 ↔ 1
    3(198696596-198717349)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.136872 Xenopus laevis transcribed sequence with moderate similarity more 75.72(n)    BJ060533.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc638942 hypothetical protein MGC63894 73.89(n)   393310  BC053137.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CHORD1 , 3 zinc ion binding3
    CHORD1
    43(a)3
    53.16(n)1
    46.18(a)1
      95E83
    428741  NM_142969.41  NP_651226.11 
    worm
    (Caenorhabditis elegans)
    Secernentea chp-11 , 3 chp-11 35(a)3
    53.4(n)1
    38.46(a)1
      I(5103811-5104915)3
    1721381  NM_059118.41  NP_491519.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PBS21 PBS2 47.52(n)
    36.92(a)
      835244  NM_124549.7  NP_568762.6 


    ENSEMBL Gene Tree for CHORDC1 (if available)
    TreeFam Gene Tree for CHORDC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHORDC1 gene
    ITGB1BP22  
    1 SIMAP similar gene for CHORDC1 using alignment to 7 protein entries:     CHRD1_HUMAN (see all proteins):
    ITGB1BP2

    Find genes that share paralogs with CHORDC1           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for CHORDC1
    PGOHUM00000247882 PGOHUM00000234841 PGOHUM00000244753 PGOHUM00000240026 PGOHUM00000246129


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHORDC1 (see all 551)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs361770121,2
    C,F--89933319(+) AAATGT/CTCTAT 2 -- int16Minor allele frequency- C:0.16NA EA 248
    rs1861650941,2
    --89933331(+) ATAACC/GTAAGA 2 -- int10--------
    rs353331401,2
    C--89933374(+) ACTGT-/TTGTA 
            
    TGTAT
    2 -- int10--------
    rs110189071,2
    C,F,A--89933609(+) AGAAAT/CAAATC 2 -- ut319Minor allele frequency- C:0.49NA CSA WA EA 369
    rs1155622691,2
    F--89933618(+) TCAATA/CAGCAC 2 -- ut311Minor allele frequency- C:0.04WA 118
    rs110189081,2
    C,F,A--89933663(+) ACATAT/CGCTAC 2 -- ut3113Minor allele frequency- C:0.48NA CSA WA EA 512
    rs1429826061,2
    C--89933718(+) TTTTT-/TATCTG 2 -- ut310--------
    rs340957341,2
    C--89933814(+) ATGTA-/TGTGTGT 2 -- ut310--------
    rs714722931,2
    C--89933815(+) TGTGT-/GT/TG 
            
    ATAAA
    4 -- ut311NA 2
    rs1910223361,2
    --89933822(+) TGTGTA/GTGTGT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for CHORDC1 (89933597 - 89956532 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHORDC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv468787CNV Loss19166990
    nsv898142CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHORDC1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604353    OMIM disorders: --

    1 disease for CHORDC1:    
    About MalaCards
    inclusion conjunctivitis

    1 disease from the University of Copenhagen DISEASES database for CHORDC1:
    Inclusion conjunctivitis

    Find genes that share disorders with CHORDC1           About GenesLikeMe

    Genetic Association Database (GAD): CHORDC1
    Human Genome Epidemiology (HuGE) Navigator: CHORDC1 (1 document)

    Export disorders for CHORDC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHORDC1 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with CHORDC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans. (PubMed id 10571178)1, 2, 3 Shirasu K....Schulze-Lefert P. (Cell 1999)
    2. A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. (PubMed id 19875381)1, 2 Gano J.J. and Simon J.A. (Mol. Cell. Proteomics 2010)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1. (PubMed id 23184943)1 Hong T.J....Hahn J.S. (J. Biol. Chem. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    10. Sequence and structural analyses of nuclear export signals in the NESdb database. (PubMed id 22833565)1 Xu D....Chook Y.M. (Mol. Biol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26973 HGNC: 14525 AceView: CHORDC1 Ensembl:ENSG00000110172 euGenes: HUgn26973
    ECgene: CHORDC1 H-InvDB: CHORDC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHORDC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHORDC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CHORDC1 gene:
    Search GeneIP for patents involving CHORDC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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