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CHODL Gene

protein-coding   GIFtS: 49
GCID: GC21P019273

Chondrolectin

(Previous name: chromosome 21 open reading frame 68)
(Previous symbol: C21orf68)
  Search for CHODL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
chondrolectin1 2
C21orf681 2 3
Transmembrane Protein MT752 3
Chromosome 21 Open Reading Frame 681
MT752

External Ids:    HGNC: 178071   Entrez Gene: 1405782   Ensembl: ENSG000001546457   OMIM: 6072475   UniProtKB: Q9H9P23   

Export aliases for CHODL gene to outside databases

Previous GC identifers: GC21P016281 GC21P018538 GC21P018539 GC21P018195 GC21P019166 GC21P005005


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHODL Gene:
This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type
lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins
and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several
transcript variants encoding a few different isoforms have been found for this gene. (provided by RefSeq, Feb
2011)

GeneCards Summary for CHODL Gene:
CHODL (chondrolectin) is a protein-coding gene. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is LAYN.

Gene Wiki entry for CHODL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000021.9  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHODL gene promoter:
         LHX3b/Lhx3b   RP58   Pax-2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Pax-2a   Nkx2-5   E47   Sox9   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHODL promoter sequence
   Search Chromatin IP Primers for CHODL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHODL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q11.2   Ensembl cytogenetic band:  21q21.1   HGNC cytogenetic band: 21q11.2

CHODL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHODL gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P019273:  view genomic region     (about GC identifiers)

Start:
19,273,580 bp from pter      End:
19,639,690 bp from pter
Size:
366,111 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHODL_HUMAN, Q9H9P2 (See protein sequence)
Recommended Name: Chondrolectin precursor  
Size: 273 amino acids; 30431 Da
Miscellaneous: A protein of the expected size has been detected by antibody binding and Western blot in at least
one of the analyzed tissues or cells (PubMed:22042635)
Secondary accessions: B2R9C0 B4DJB8 Q7Z798 Q7Z799 Q7Z7A0 Q9HCY3
Alternative splicing: 4 isoforms:  Q9H9P2-1   Q9H9P2-2   Q9H9P2-3   Q9H9P2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHODL: NX_Q9H9P2

Explore proteomics data for CHODL at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn86

  • See CHODL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001191103.1  NP_001191104.1  NP_001191105.1  NP_001191106.1  NP_001191107.1  NP_079220.2  

    ENSEMBL proteins: 
     ENSP00000382993   ENSP00000382996   ENSP00000383001   ENSP00000382992   ENSP00000299295  
     ENSP00000443566   ENSP00000339975  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR016187 C-type_lectin_fold
     IPR016186 C-type_lectin-like
     IPR001304 C-type_lectin

    Graphical View of Domain Structure for InterPro Entry Q9H9P2

    ProtoNet protein and cluster: Q9H9P2

    UniProtKB/Swiss-Prot: CHODL_HUMAN, Q9H9P2
    Similarity: Contains 1 C-type lectin domain


    Find genes that share domains with CHODL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005540NOT hyaluronic acid binding IDA12079284
    GO:0030246carbohydrate binding IEA--
         
    Find genes that share ontologies with CHODL           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Chodl (no phenotypes)

    Find genes that share phenotypes with CHODL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chodltm1Lex for CHODL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHODL
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    Selected qRT-PCR Assays for microRNAs that regulate CHODL (see all 20):
    hsa-miR-3910 hsa-miR-323-3p hsa-miR-431 hsa-miR-507 hsa-miR-374a* hsa-miR-548m hsa-miR-124 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidCHODL 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHODL_HUMAN, Q9H9P2: Cytoplasm. Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0016021integral component of membrane IEA--
    GO:0048471perinuclear region of cytoplasm IDA12079284

    Find genes that share ontologies with CHODL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHODL
    Interactions:

        Search GeneGlobe Interaction Network for CHODL

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CHODL (ENSP000002992954) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT5ENSP000003685524STRING: ENSP00000368552
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development NAS12079284

    Find genes that share ontologies with CHODL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHODL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHODL gene (6 alternative transcripts): 
    NM_001204174.1  NM_001204175.1  NM_001204176.1  NM_001204177.1  NM_001204178.1  NM_024944.2  

    Unigene Cluster for CHODL:

    Chondrolectin
    Hs.283725  [show with all ESTs]
    Unigene Representative Sequence: NM_024944
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000400128(uc002ykr.3 uc002yks.3 uc021whr.1 uc002ykt.3 uc002yku.3)
    ENST00000400131 ENST00000400135 ENST00000400127(uc021whs.1) ENST00000299295(uc002ykv.3)
    ENST00000543733 ENST00000338326
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CHODL (see all 20):
    hsa-miR-3910 hsa-miR-323-3p hsa-miR-431 hsa-miR-507 hsa-miR-374a* hsa-miR-548m hsa-miR-124 hsa-miR-641
    SwitchGear 3'UTR luciferase reporter plasmidCHODL 3' UTR sequence
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    Additional mRNA sequence: 

    AF257472.1 AF523313.1 AF523314.1 AF523315.1 AK022689.1 AK296009.1 AK313725.1 AY358608.1 
    BC009418.1 

    4 DOTS entries:

    DT.91679032  DT.100748590  DT.100748591  DT.100694217 

    Selected AceView cDNA sequences (see all 54):

    NM_024944 AK022689 AA235925 BC009418 AF257472 AW452240 CA446379 AU125569 
    AI332692 AI089920 AI378795 AF523315 AI147017 BI828968 AA976845 AI093869 
    BE313146 BF979864 AL700069 AY358608 W07506 AW449247 AA236983 BM552834 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CHODL    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
    SP1:                                          
    SP2:                          -               


    ECgene alternative splicing isoforms for CHODL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHODL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATTTTGC
    CHODL Expression
    About this image


    CHODL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Gonad
             XY Germ Cells Testis Cord
    CHODL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHODL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283725

    UniProtKB/Swiss-Prot: CHODL_HUMAN, Q9H9P2
    Tissue specificity: Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of
    testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp
    of spleen

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CHODL gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chodl1 , 5 chondrolectin1, 5 87.67(n)1
    92.67(a)1
      16 (45.39 cM)5
    2460481  NM_139134.31  NP_624360.21 
     789309485 
    chicken
    (Gallus gallus)
    Aves CHODL1 chondrolectin 77.52(n)
    78.82(a)
      418474  XM_416682.4  XP_416682.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHODL6
    chondrolectin
    58(a)
    1 ↔ 1
    3(153443894-153476023)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia chodl1 chondrolectin 71.98(n)
    73.15(a)
      100145416  NM_001126877.1  NP_001120349.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chodl1 chondrolectin 64.52(n)
    67.74(a)
      550240  NM_001017578.2  NP_001017578.1 


    ENSEMBL Gene Tree for CHODL (if available)
    TreeFam Gene Tree for CHODL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHODL gene
    LAYN2  
    1 SIMAP similar gene for CHODL using alignment to 1 protein entry:     CHODL_HUMAN:
    LAYN

    Find genes that share paralogs with CHODL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHODL (see all 8183)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs560794361,2
    C,F--9842200(+) CTTATG/ATATTA 4 -- us2k12Minor allele frequency- A:0.09WA 120
    rs1487748861,2
    C--9842203(+) ATGTAG/TTATTA 4 -- us2k10--------
    rs72804901,2
    C,F,A,H--9842280(+) TTTACG/ATGGTA 4 -- us2k111Minor allele frequency- A:0.42NA WA CSA EA 374
    rs99842381,2
    C,F,A,H--9842283(+) ACGTGG/ATAAAT 4 -- us2k19Minor allele frequency- A:0.38NA WA EA 370
    rs1130339381,2
    C,F--9842292(+) ATATGG/CTACTT 4 -- us2k12Minor allele frequency- C:0.09WA 120
    rs1922932821,2
    --9842434(+) GAAAAC/TATATA 4 -- us2k10--------
    rs1420935971,2
    --9842437(+) AACATA/GTATGT 4 -- us2k10--------
    rs1463639561,2
    C--9842506(+) GCCAGA/GGCTGA 4 -- us2k10--------
    rs1832555871,2
    --9842541(+) CCAGGA/CAGAGA 4 -- us2k10--------
    rs758043301,2
    C--9842614(+) ATAACA/CCTGGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHODL (19273580 - 19523580 bp, first 250kb of CHODL)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CHODL (see all 26):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1372324CNV Deletion17803354
    esv2662708CNV Deletion23128226
    esv2723210CNV Deletion23290073
    esv2471706CNV Deletion19546169
    esv996017CNV Deletion20482838
    esv2723211CNV Deletion23290073
    esv2421551CNV Deletion20811451
    esv1006254CNV Insertion20482838
    esv1422720CNV Insertion17803354
    esv273037CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607247    OMIM disorders: --


    Find genes that share disorders with CHODL           About GenesLikeMe

    Genetic Association Database (GAD): CHODL

    Export disorders for CHODL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHODL gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CHODL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. (PubMed id 12079284)1, 2, 3 Weng L.... Merregaert J. (Genomics 2002)
    2. A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. (PubMed id 12621022)1, 2, 9 Weng L.... Merregaert J. (J. Biol. Chem. 2003)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PubMed id 11707072)1, 2 Reymond A....Antonarakis S.E. (Genomics 2001)
    7. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    8. Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin. (PubMed id 17606388)1, 9 Claessens A....Merregaert J. (Cell Biol. Int. 2007)
    9. Genetic variants associated with disordered eating. (PubMed id 23568457)1 Wade T.D....Martin N.G. (Int J Eat Disord 2013)
    10. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PubMed id 23648065)1 Low S.K....Nakamura Y. (Cancer Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140578 HGNC: 17807 AceView: CHODL Ensembl:ENSG00000154645 euGenes: HUgn140578
    ECgene: CHODL H-InvDB: CHODL

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHODL Pharmacogenomics, SNPs, Pathways
    Functional Glycomics Gateway - Glycan Bindinghttp://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_185

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHODL gene:
    Search GeneIP for patents involving CHODL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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