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Aliases for CHODL Gene

Aliases for CHODL Gene

  • Chondrolectin 2 3
  • Transmembrane Protein MT75 3 4
  • C21orf68 3 4
  • Chromosome 21 Open Reading Frame 68 2
  • PRED12 3
  • MT75 3

External Ids for CHODL Gene

Previous HGNC Symbols for CHODL Gene

  • C21orf68

Previous GeneCards Identifiers for CHODL Gene

  • GC21P016281
  • GC21P018538
  • GC21P018539
  • GC21P018195
  • GC21P019166
  • GC21P005005
  • GC21P019273
  • GC21P017901

Summaries for CHODL Gene

Entrez Gene Summary for CHODL Gene

  • This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for CHODL Gene

CHODL (Chondrolectin) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is LAYN.

Gene Wiki entry for CHODL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHODL Gene

Genomics for CHODL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHODL Gene

17,819,595 bp from pter
18,267,373 bp from pter
447,779 bases
Plus strand

Genomic View for CHODL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHODL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHODL Gene

Proteins for CHODL Gene

  • Protein details for CHODL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R9C0
    • B4DJB8
    • Q7Z798
    • Q7Z799
    • Q7Z7A0
    • Q9HCY3

    Protein attributes for CHODL Gene

    273 amino acids
    Molecular mass:
    30431 Da
    Quaternary structure:
    No Data Available
    • A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.

    Alternative splice isoforms for CHODL Gene


neXtProt entry for CHODL Gene

Proteomics data for CHODL Gene at MOPED

Post-translational modifications for CHODL Gene

Antibody Products

  • R&D Systems Antibodies for CHODL (Chondrolectin)

No data available for DME Specific Peptides for CHODL Gene

Domains & Families for CHODL Gene

Protein Domains for CHODL Gene

Suggested Antigen Peptide Sequences for CHODL Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CHODL: view

No data available for Gene Families for CHODL Gene

Function for CHODL Gene

Gene Ontology (GO) - Molecular Function for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005540 NOT hyaluronic acid binding IDA 12079284
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CHODL: view
genes like me logo Genes that share phenotypes with CHODL: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHODL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHODL Gene

Localization for CHODL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHODL Gene

Cytoplasm. Membrane; Single-pass type I membrane protein.

Gene Ontology (GO) - Cellular Components for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22042635
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12079284
genes like me logo Genes that share ontologies with CHODL: view

No data available for Subcellular locations from COMPARTMENTS for CHODL Gene

Pathways & Interactions for CHODL Gene

SuperPathways for CHODL Gene

No Data Available

Interacting Proteins for CHODL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000299295 for CHODL Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development NAS 12079284
GO:0010975 regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with CHODL: view

No data available for Pathways by source and SIGNOR curated interactions for CHODL Gene

Drugs & Compounds for CHODL Gene

No Compound Related Data Available

Transcripts for CHODL Gene

Unigene Clusters for CHODL Gene

Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHODL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHODL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP2: -

Relevant External Links for CHODL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHODL Gene

mRNA expression in normal human tissues for CHODL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHODL Gene

This gene is overexpressed in Testis (x13.1), Kidney - Cortex (x4.9), and Brain - Hypothalamus (x4.8).

Protein differential expression in normal tissues from HIPED for CHODL Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHODL Gene

SOURCE GeneReport for Unigene cluster for CHODL Gene Hs.283725

mRNA Expression by UniProt/SwissProt for CHODL Gene

Tissue specificity: Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen.
genes like me logo Genes that share expression patterns with CHODL: view

Protein tissue co-expression partners for CHODL Gene

Primer Products

In Situ Assay Products

Orthologs for CHODL Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHODL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHODL 35
  • 91.21 (n)
  • 97.07 (a)
  • 97 (a)
(Canis familiaris)
Mammalia CHODL 35
  • 92.8 (n)
  • 94.51 (a)
  • 95 (a)
(Mus musculus)
Mammalia Chodl 35
  • 87.67 (n)
  • 92.67 (a)
Chodl 16
Chodl 36
  • 93 (a)
(Pan troglodytes)
Mammalia CHODL 35
  • 99.76 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Chodl 35
  • 87.62 (n)
  • 94.12 (a)
(Monodelphis domestica)
Mammalia CHODL 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CHODL 36
  • 72 (a)
(Gallus gallus)
Aves CHODL 35
  • 77.52 (n)
  • 78.82 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia CHODL 36
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chodl 35
  • 71.98 (n)
  • 73.15 (a)
(Danio rerio)
Actinopterygii chodl 35
  • 64.52 (n)
  • 67.74 (a)
chodl 36
  • 53 (a)
Species with no ortholog for CHODL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHODL Gene

Gene Tree for CHODL (if available)
Gene Tree for CHODL (if available)

Paralogs for CHODL Gene

Paralogs for CHODL Gene

(1) SIMAP similar genes for CHODL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHODL: view

Variants for CHODL Gene

Structural Variations from Database of Genomic Variants (DGV) for CHODL Gene

Variant ID Type Subtype PubMed ID
esv26906 CNV Loss 19812545
esv996017 CNV Deletion 20482838
esv2662708 CNV Deletion 23128226
esv2723210 CNV Deletion 23290073
esv1372324 CNV Deletion 17803354
dgv100e180 CNV Loss 20482838
nsv828828 CNV Loss 20364138
esv2421551 CNV Deletion 20811451
nsv517400 CNV Loss 19592680
nsv459104 CNV Loss 19166990
esv2723211 CNV Deletion 23290073
esv2751925 CNV Loss 17911159
esv2471706 CNV Deletion 19546169
nsv3469 CNV Insertion 18451855
esv28281 CNV Loss 19812545
nsv913432 CNV Loss 21882294
nsv509791 CNV Insertion 20534489
esv1001519 CNV Insertion 20482838
esv267430 CNV Insertion 20981092
esv273037 CNV Insertion 20981092
nsv510495 CNV Loss 20534489
esv1006254 CNV Insertion 20482838
esv1422720 CNV Insertion 17803354
nsv459105 CNV Loss 19166990
esv1632755 CNV Insertion 17803354
nsv819544 CNV Gain 19587683

Variation tolerance for CHODL Gene

Residual Variation Intolerance Score: 32.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHODL Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CHODL Gene

Disorders for CHODL Gene

Relevant External Links for CHODL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CHODL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHODL Gene

Publications for CHODL Gene

  1. Identification of novel spinal cholinergic genetic subtypes disclose Chodl and Pitx2 as markers for fast motor neurons and partition cells. (PMID: 20437528) Enjin A. … Kullander K. (J. Comp. Neurol. 2010) 23 67
  2. The cytoplasmic domain of chondrolectin interacts with the beta-subunit of Rab geranylgeranyl transferase. (PMID: 18161010) Claessens A. … Merregaert J. (Cell. Mol. Biol. Lett. 2008) 23 67
  3. Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin. (PMID: 17606388) Claessens A. … Merregaert J. (Cell Biol. Int. 2007) 23 67
  4. A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. (PMID: 12621022) Weng L. … Merregaert J. (J. Biol. Chem. 2003) 23 67
  5. Isolation and characterization of chondrolectin (Chodl), a novel C-type lectin predominantly expressed in muscle cells. (PMID: 12711387) Weng L. … Merregaert J. (Gene 2003) 23 67

Products for CHODL Gene

Sources for CHODL Gene

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