Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHODL Gene

Aliases for CHODL Gene

  • Chondrolectin 2 3 3 5
  • Transmembrane Protein MT75 3 4
  • C21orf68 3 4
  • Chromosome 21 Open Reading Frame 68 2
  • PRED12 3
  • MT75 3

External Ids for CHODL Gene

Previous HGNC Symbols for CHODL Gene

  • C21orf68

Previous GeneCards Identifiers for CHODL Gene

  • GC21P016281
  • GC21P018538
  • GC21P018539
  • GC21P018195
  • GC21P019166
  • GC21P005005
  • GC21P019273
  • GC21P017901

Summaries for CHODL Gene

Entrez Gene Summary for CHODL Gene

  • This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for CHODL Gene

CHODL (Chondrolectin) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is LAYN.

Gene Wiki entry for CHODL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHODL Gene

Genomics for CHODL Gene

Regulatory Elements for CHODL Gene

Enhancers for CHODL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21F017958 0.8 FANTOM5 14.2 +139.5 139462 0.3 CHODL GC21M017929 GC21P018025
GH21F017847 1.2 FANTOM5 ENCODE 12 +29.0 28965 1.6 PKNOX1 MXI1 USF1 TBL1XR1 JUN SIN3A CBX5 EED ETV6 FOS CHODL CHODL-AS1 RPL37P3 C21orf91-OT1 LOC105372743
GH21F017672 0.6 ENCODE 11.7 -146.2 -146220 1.3 RFX1 TEAD4 CHODL CHODL-AS1 RPL37P3 ENSG00000226956 GC21M017663
GH21F017817 1.1 ENCODE 7.4 -0.3 -288 4.2 ATF1 ARNT WRNIP1 SIN3A DMAP1 ZNF48 YY1 GLIS2 ELK1 ZNF143 C21orf91-OT1 CHODL C21orf91 LOC105372743
GH21F017798 0.7 FANTOM5 ENCODE 6.6 -20.3 -20274 1.7 C21orf91-OT1 CHODL C21orf91 LOC105372743
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CHODL on UCSC Golden Path with GeneCards custom track

Promoters for CHODL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000611773 -594 3200 ATF1 ARNT WRNIP1 SIN3A DMAP1 ZNF48 YY1 GLIS2 ELK1 ZNF143

Genomic Location for CHODL Gene

17,819,595 bp from pter
18,267,373 bp from pter
447,779 bases
Plus strand

Genomic View for CHODL Gene

Genes around CHODL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHODL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHODL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHODL Gene

Proteins for CHODL Gene

  • Protein details for CHODL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R9C0
    • B4DJB8
    • Q7Z798
    • Q7Z799
    • Q7Z7A0
    • Q9HCY3

    Protein attributes for CHODL Gene

    273 amino acids
    Molecular mass:
    30431 Da
    Quaternary structure:
    No Data Available
    • A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.

    Alternative splice isoforms for CHODL Gene


neXtProt entry for CHODL Gene

Post-translational modifications for CHODL Gene

Antibody Products

  • R&D Systems Antibodies for CHODL (Chondrolectin)
  • Cloud-Clone Corp. Antibodies for CHODL

No data available for DME Specific Peptides for CHODL Gene

Domains & Families for CHODL Gene

Gene Families for CHODL Gene

Protein Domains for CHODL Gene

Suggested Antigen Peptide Sequences for CHODL Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 C-type lectin domain.
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CHODL: view

Function for CHODL Gene

Gene Ontology (GO) - Molecular Function for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005540 NOT hyaluronic acid binding IDA 12079284
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CHODL: view
genes like me logo Genes that share phenotypes with CHODL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHODL

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHODL Gene

Localization for CHODL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHODL Gene

Cytoplasm. Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for CHODL Gene COMPARTMENTS Subcellular localization image for CHODL gene
Compartment Confidence
plasma membrane 2

Gene Ontology (GO) - Cellular Components for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 22042635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12079284
genes like me logo Genes that share ontologies with CHODL: view

Pathways & Interactions for CHODL Gene

SuperPathways for CHODL Gene

No Data Available

Interacting Proteins for CHODL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000299295 Q9H9P2-CHODL_HUMAN for CHODL Gene via STRING IID

Gene Ontology (GO) - Biological Process for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development NAS 12079284
GO:0010975 regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with CHODL: view

No data available for Pathways by source and SIGNOR curated interactions for CHODL Gene

Transcripts for CHODL Gene

Unigene Clusters for CHODL Gene

Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHODL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP2: -

Relevant External Links for CHODL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHODL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHODL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHODL Gene

This gene is overexpressed in Testis (x13.1), Kidney - Cortex (x4.9), and Brain - Hypothalamus (x4.8).

Protein differential expression in normal tissues from HIPED for CHODL Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHODL Gene

Protein tissue co-expression partners for CHODL Gene

NURSA nuclear receptor signaling pathways regulating expression of CHODL Gene:


SOURCE GeneReport for Unigene cluster for CHODL Gene:


mRNA Expression by UniProt/SwissProt for CHODL Gene:

Tissue specificity: Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen.
genes like me logo Genes that share expression patterns with CHODL: view

Primer Products

Orthologs for CHODL Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHODL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHODL 34 35
  • 99.76 (n)
(Canis familiaris)
Mammalia CHODL 34 35
  • 92.8 (n)
(Bos Taurus)
Mammalia CHODL 34 35
  • 91.21 (n)
(Mus musculus)
Mammalia Chodl 34 16 35
  • 87.67 (n)
(Rattus norvegicus)
Mammalia Chodl 34
  • 87.62 (n)
(Monodelphis domestica)
Mammalia CHODL 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CHODL 35
  • 72 (a)
(Gallus gallus)
Aves CHODL 34 35
  • 77.52 (n)
(Anolis carolinensis)
Reptilia CHODL 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chodl 34
  • 71.98 (n)
(Danio rerio)
Actinopterygii chodl 34 35
  • 64.52 (n)
Species where no ortholog for CHODL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHODL Gene

Gene Tree for CHODL (if available)
Gene Tree for CHODL (if available)

Paralogs for CHODL Gene

Paralogs for CHODL Gene

(1) SIMAP similar genes for CHODL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHODL: view

Variants for CHODL Gene

Sequence variations from dbSNP and Humsavar for CHODL Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1002244 -- 18,183,699(+) TTTAT(A/G)CACAC intron-variant
rs10048875 -- 18,127,673(+) CATTG(G/T)ttttt intron-variant
rs1006688 -- 18,183,445(+) CAAAG(C/T)AGAGG intron-variant
rs1006689 -- 18,183,632(+) GGAAG(C/T)AAGGC intron-variant
rs1008443 -- 17,929,880(+) ATCAC(G/T)GCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHODL Gene

Variant ID Type Subtype PubMed ID
dgv100e180 CNV loss 20482838
dgv7769n54 CNV loss 21841781
dgv7770n54 CNV gain+loss 21841781
dgv7771n54 CNV gain+loss 21841781
dgv7772n54 CNV gain+loss 21841781
dgv7773n54 CNV loss 21841781
dgv7774n54 CNV gain+loss 21841781
dgv7775n54 CNV loss 21841781
dgv7776n54 CNV loss 21841781
dgv7777n54 CNV loss 21841781
dgv7778n54 CNV loss 21841781
esv1001519 CNV insertion 20482838
esv1006254 CNV insertion 20482838
esv1372324 CNV deletion 17803354
esv1422720 CNV insertion 17803354
esv1632755 CNV insertion 17803354
esv2421551 CNV deletion 20811451
esv2471706 CNV deletion 19546169
esv2662708 CNV deletion 23128226
esv26906 CNV loss 19812545
esv2723210 CNV deletion 23290073
esv2723211 CNV deletion 23290073
esv2751925 CNV loss 17911159
esv2763238 CNV gain 21179565
esv2763239 CNV loss 21179565
esv28281 CNV loss 19812545
esv2960457 CNV deletion 24192839
esv3054902 CNV deletion 24192839
esv3378916 CNV insertion 20981092
esv3557483 CNV deletion 23714750
esv3557485 CNV deletion 23714750
esv3568116 CNV loss 25503493
esv3646489 CNV loss 21293372
esv3646490 CNV gain 21293372
esv3646494 CNV loss 21293372
esv996017 CNV deletion 20482838
nsv1072167 CNV deletion 25765185
nsv1073117 CNV deletion 25765185
nsv1073118 CNV deletion 25765185
nsv1114268 CNV deletion 24896259
nsv1139008 CNV deletion 24896259
nsv1139009 CNV deletion 24896259
nsv3469 CNV insertion 18451855
nsv459104 CNV loss 19166990
nsv459105 CNV loss 19166990
nsv509791 CNV insertion 20534489
nsv510495 OTHER sequence alteration 20534489
nsv517400 CNV loss 19592680
nsv587086 CNV loss 21841781
nsv587088 CNV gain 21841781
nsv587101 CNV gain+loss 21841781
nsv587105 CNV loss 21841781
nsv587110 CNV gain 21841781
nsv587119 CNV loss 21841781
nsv587135 CNV loss 21841781
nsv587136 CNV loss 21841781
nsv587137 CNV loss 21841781
nsv819544 CNV gain 19587683
nsv828828 CNV loss 20364138

Variation tolerance for CHODL Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHODL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHODL Gene

Disorders for CHODL Gene

Relevant External Links for CHODL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CHODL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHODL Gene

Publications for CHODL Gene

  1. A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. (PMID: 12621022) Weng L. … Merregaert J. (J. Biol. Chem. 2003) 3 4 22 64
  2. Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. (PMID: 12079284) Weng L. … Merregaert J. (Genomics 2002) 2 3 4 64
  3. Antibody-based protein profiling of the human chromosome 21. (PMID: 22042635) Uhlen M. … Sivertsson A. (Mol. Cell. Proteomics 2012) 3 4 64
  4. Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin. (PMID: 17606388) Claessens A. … Merregaert J. (Cell Biol. Int. 2007) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for CHODL Gene

Sources for CHODL Gene

Loading form....