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Aliases for CHODL Gene

Aliases for CHODL Gene

  • Chondrolectin 2 3
  • Transmembrane Protein MT75 3 4
  • C21orf68 3 4
  • Chromosome 21 Open Reading Frame 68 2
  • PRED12 3
  • MT75 3

External Ids for CHODL Gene

Previous HGNC Symbols for CHODL Gene

  • C21orf68

Previous GeneCards Identifiers for CHODL Gene

  • GC21P016281
  • GC21P018538
  • GC21P018539
  • GC21P018195
  • GC21P019166
  • GC21P005005
  • GC21P019273

Summaries for CHODL Gene

Entrez Gene Summary for CHODL Gene

  • This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for CHODL Gene

CHODL (Chondrolectin) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is LAYN.

Gene Wiki entry for CHODL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHODL Gene

Genomics for CHODL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHODL Gene

Start:
17,901,263 bp from pter
End:
18,267,373 bp from pter
Size:
366,111 bases
Orientation:
Plus strand

Genomic View for CHODL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHODL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHODL Gene

Proteins for CHODL Gene

  • Protein details for CHODL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9P2-CHODL_HUMAN
    Recommended name:
    Chondrolectin
    Protein Accession:
    Q9H9P2
    Secondary Accessions:
    • B2R9C0
    • B4DJB8
    • Q7Z798
    • Q7Z799
    • Q7Z7A0
    • Q9HCY3

    Protein attributes for CHODL Gene

    Size:
    273 amino acids
    Molecular mass:
    30431 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.

    Alternative splice isoforms for CHODL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHODL Gene

Proteomics data for CHODL Gene at MOPED

Post-translational modifications for CHODL Gene

Antibody Products

  • R&D Systems Antibodies for CHODL (Chondrolectin)

No data available for DME Specific Peptides for CHODL Gene

Domains for CHODL Gene

Protein Domains for CHODL Gene

Suggested Antigen Peptide Sequences for CHODL Gene

Graphical View of Domain Structure for InterPro Entry

Q9H9P2

UniProtKB/Swiss-Prot:

CHODL_HUMAN :
  • Q9H9P2
Domain:
  • Contains 1 C-type lectin domain.
genes like me logo Genes that share domains with CHODL: view

No data available for Gene Families for CHODL Gene

Function for CHODL Gene

Gene Ontology (GO) - Molecular Function for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005540 NOT hyaluronic acid binding IDA 12079284
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CHODL: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHODL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHODL Gene

Localization for CHODL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHODL Gene

Cytoplasm. Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHODL Gene COMPARTMENTS Subcellular localization image for CHODL gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22042635
GO:0016021 integral component of membrane IEA --
GO:0048471 perinuclear region of cytoplasm IDA 12079284
genes like me logo Genes that share ontologies with CHODL: view

Pathways for CHODL Gene

SuperPathways for CHODL Gene

No Data Available

Interacting Proteins for CHODL Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299295%0d%0a9606.ENSP00000368552%0d%0a
Selected Interacting proteins: ENSP00000299295 for CHODL Gene via STRING

Symbol External ID(s) Details
SIRT5

Gene Ontology (GO) - Biological Process for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development NAS 12079284
genes like me logo Genes that share ontologies with CHODL: view

No data available for Pathways by source for CHODL Gene

Transcripts for CHODL Gene

Unigene Clusters for CHODL Gene

Chondrolectin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHODL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHODL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for CHODL Gene

GeneLoc Exon Structure for
CHODL
ECgene alternative splicing isoforms for
CHODL

Expression for CHODL Gene

mRNA expression in normal human tissues for CHODL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHODL Gene

This gene is overexpressed in Testis (13.1), Kidney - Cortex (4.9), and Brain - Hypothalamus (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHODL Gene

SOURCE GeneReport for Unigene cluster for CHODL Gene Hs.283725

mRNA Expression by UniProt/SwissProt for CHODL Gene

Q9H9P2-CHODL_HUMAN
Tissue specificity: Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen.
genes like me logo Genes that share expressions with CHODL: view

In Situ Assay Products

Orthologs for CHODL Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHODL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHODL 35
  • 99.76 (n)
  • 100 (a)
CHODL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHODL 35
  • 91.21 (n)
  • 97.07 (a)
CHODL 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHODL 35
  • 92.8 (n)
  • 94.51 (a)
CHODL 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chodl 35
  • 87.67 (n)
  • 92.67 (a)
Chodl 16
Chodl 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHODL 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHODL 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chodl 35
  • 87.62 (n)
  • 94.12 (a)
chicken
(Gallus gallus)
Aves CHODL 35
  • 77.52 (n)
  • 78.82 (a)
CHODL 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHODL 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chodl 35
  • 71.98 (n)
  • 73.15 (a)
zebrafish
(Danio rerio)
Actinopterygii chodl 35
  • 64.52 (n)
  • 67.74 (a)
chodl 36
  • 53 (a)
OneToOne
Species with no ortholog for CHODL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHODL Gene

ENSEMBL:
Gene Tree for CHODL (if available)
TreeFam:
Gene Tree for CHODL (if available)

Paralogs for CHODL Gene

Paralogs for CHODL Gene

Selected SIMAP similar genes for CHODL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHODL: view

Variants for CHODL Gene

Sequence variations from dbSNP and Humsavar for CHODL Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs16741 -- 18,267,228(-) CATTT(-/TCTA)TCTAT utr-variant-3-prime
rs28500 -- 17,957,906(+) AATAC(C/G)CCTCA intron-variant
rs117216 -- 17,975,952(-) ATTAT(C/T)CAAAA intron-variant
rs125679 -- 17,981,147(+) TATGA(A/G)TAGAA intron-variant
rs149335 -- 18,045,394(-) aaaga(C/G)agttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHODL Gene

Variant ID Type Subtype PubMed ID
esv26906 CNV Loss 19812545
esv996017 CNV Deletion 20482838
esv2662708 CNV Deletion 23128226
esv2723210 CNV Deletion 23290073
esv1372324 CNV Deletion 17803354
dgv100e180 CNV Loss 20482838
nsv828828 CNV Loss 20364138
esv2421551 CNV Deletion 20811451
nsv517400 CNV Loss 19592680
nsv459104 CNV Loss 19166990
esv2723211 CNV Deletion 23290073
esv2751925 CNV Loss 17911159
esv2471706 CNV Deletion 19546169
nsv3469 CNV Insertion 18451855
esv28281 CNV Loss 19812545
nsv913432 CNV Loss 21882294
nsv509791 CNV Insertion 20534489
esv1001519 CNV Insertion 20482838
esv267430 CNV Insertion 20981092
esv273037 CNV Insertion 20981092
nsv510495 CNV Loss 20534489
esv1006254 CNV Insertion 20482838
esv1422720 CNV Insertion 17803354
nsv459105 CNV Loss 19166990
esv1632755 CNV Insertion 17803354
nsv819544 CNV Gain 19587683

Relevant External Links for CHODL Gene

HapMap Linkage Disequilibrium report
CHODL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHODL Gene

Disorders for CHODL Gene

Relevant External Links for CHODL

Genetic Association Database (GAD)
CHODL
genes like me logo Genes that share disorders with CHODL: view

No data available for UniProtKB/Swiss-Prot for CHODL Gene

Publications for CHODL Gene

  1. A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. (PMID: 12621022) Weng L. … Merregaert J. (J. Biol. Chem. 2003) 3 4 23
  2. Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. (PMID: 12079284) Weng L. … Merregaert J. (Genomics 2002) 2 3 4
  3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  4. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. (PMID: 11707072) Reymond A. … Antonarakis S.E. (Genomics 2001) 3 4
  5. Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin. (PMID: 17606388) Claessens A. … Merregaert J. (Cell Biol. Int. 2007) 3 23

Products for CHODL Gene

Sources for CHODL Gene

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