Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHODL Gene

Aliases for CHODL Gene

  • Chondrolectin 2 3 3 5
  • Transmembrane Protein MT75 3 4
  • C21orf68 3 4
  • Chromosome 21 Open Reading Frame 68 2
  • PRED12 3
  • MT75 3

External Ids for CHODL Gene

Previous HGNC Symbols for CHODL Gene

  • C21orf68

Previous GeneCards Identifiers for CHODL Gene

  • GC21P016281
  • GC21P018538
  • GC21P018539
  • GC21P018195
  • GC21P019166
  • GC21P005005
  • GC21P019273
  • GC21P017901

Summaries for CHODL Gene

Entrez Gene Summary for CHODL Gene

  • This gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for CHODL Gene

CHODL (Chondrolectin) is a Protein Coding gene. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is LAYN.

UniProtKB/Swiss-Prot for CHODL Gene

  • May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance.

Gene Wiki entry for CHODL Gene

Additional gene information for CHODL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHODL Gene

Genomics for CHODL Gene

Regulatory Elements for CHODL Gene

Enhancers for CHODL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H017847 1.1 FANTOM5 ENCODE 12 +29.0 28965 1 PKNOX1 TBL1XR1 JUN MAX BATF FOSL1 EED FOS ATF7 ETV6 CHODL CHODL-AS1 RPL37P3 C21orf91-OT1 ENSG00000244676
GH21H017817 1.3 ENCODE dbSUPER 7.4 -0.3 -288 4 FOXA2 ARNT SIN3A DMAP1 YY1 ZNF143 ZNF207 SP3 MXD4 REST C21orf91-OT1 CHODL C21orf91 ENSG00000244676
GH21H017788 1 ENCODE dbSUPER 6.5 -29.8 -29765 2 TBL1XR1 RELA ATF7 ETV6 RUNX3 IKZF2 CREM ZBED1 CBFB TRIM22 C21orf91-OT1 CHODL LOC105372741
GH21H017798 0.8 FANTOM5 ENCODE dbSUPER 6.6 -20.3 -20274 1 C21orf91-OT1 CHODL C21orf91 ENSG00000244676
GH21H017958 0.3 FANTOM5 14.2 +139.5 139462 0 CHODL GC21M017929 GC21P018025
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHODL on UCSC Golden Path with GeneCards custom track

Genomic Location for CHODL Gene

Chromosome:
21
Start:
17,819,595 bp from pter
End:
18,267,373 bp from pter
Size:
447,779 bases
Orientation:
Plus strand

Genomic View for CHODL Gene

Genes around CHODL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHODL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHODL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHODL Gene

Proteins for CHODL Gene

  • Protein details for CHODL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9P2-CHODL_HUMAN
    Recommended name:
    Chondrolectin
    Protein Accession:
    Q9H9P2
    Secondary Accessions:
    • B2R9C0
    • B4DJB8
    • Q7Z798
    • Q7Z799
    • Q7Z7A0
    • Q9HCY3

    Protein attributes for CHODL Gene

    Size:
    273 amino acids
    Molecular mass:
    30431 Da
    Quaternary structure:
    • Interacts with RABGGTB.
    Miscellaneous:
    • A protein of the expected size has been detected by antibody binding and Western blot in at least one of the analyzed tissues or cells.

    Alternative splice isoforms for CHODL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHODL Gene

Post-translational modifications for CHODL Gene

No data available for DME Specific Peptides for CHODL Gene

Domains & Families for CHODL Gene

Gene Families for CHODL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CHODL Gene

Suggested Antigen Peptide Sequences for CHODL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CHODL: view

No data available for UniProtKB/Swiss-Prot for CHODL Gene

Function for CHODL Gene

Molecular function for CHODL Gene

UniProtKB/Swiss-Prot Function:
May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance.

Phenotypes From GWAS Catalog for CHODL Gene

Gene Ontology (GO) - Molecular Function for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005540 NOT hyaluronic acid binding IDA 12079284
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CHODL: view
genes like me logo Genes that share phenotypes with CHODL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHODL

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHODL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHODL Gene

Localization for CHODL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHODL Gene

Cytoplasm. Membrane; Single-pass type I membrane protein.
Isoform 2: Endoplasmic reticulum. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Isoform 3: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHODL gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 22042635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CHODL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CHODL Gene

Pathways & Interactions for CHODL Gene

SuperPathways for CHODL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHODL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007399 nervous system development IEA --
GO:0007517 muscle organ development NAS 12079284
GO:0010975 regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with CHODL: view

No data available for Pathways by source and SIGNOR curated interactions for CHODL Gene

Drugs & Compounds for CHODL Gene

No Compound Related Data Available

Transcripts for CHODL Gene

Unigene Clusters for CHODL Gene

Chondrolectin:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHODL
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CHODL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for CHODL Gene

GeneLoc Exon Structure for
CHODL
ECgene alternative splicing isoforms for
CHODL

Expression for CHODL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHODL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHODL Gene

This gene is overexpressed in Testis (x13.1), Kidney - Cortex (x4.9), and Brain - Hypothalamus (x4.8).

Protein differential expression in normal tissues from HIPED for CHODL Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHODL Gene



Protein tissue co-expression partners for CHODL Gene

NURSA nuclear receptor signaling pathways regulating expression of CHODL Gene:

CHODL

SOURCE GeneReport for Unigene cluster for CHODL Gene:

Hs.283725

mRNA Expression by UniProt/SwissProt for CHODL Gene:

Q9H9P2-CHODL_HUMAN
Tissue specificity: Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen. B lymphocytes express isoform 2 only; peripheral blood T lymphocytes express isoform 3 only; granulocytes and monocytes express neither isoform 2 nor isoform 3. During development of T lymphocytes, bone marrow progenitor cells express isoform 2 only; thymocytes at different stages of maturation express predominantly isoform 2 and weakly isoform 3, and mature thymocytes express only isoform 2.

Evidence on tissue expression from TISSUES for CHODL Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with CHODL: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHODL Gene

Orthologs for CHODL Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHODL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHODL 33 34
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia CHODL 33 34
  • 92.8 (n)
cow
(Bos Taurus)
Mammalia CHODL 33 34
  • 91.21 (n)
mouse
(Mus musculus)
Mammalia Chodl 33 16 34
  • 87.67 (n)
rat
(Rattus norvegicus)
Mammalia Chodl 33
  • 87.62 (n)
oppossum
(Monodelphis domestica)
Mammalia CHODL 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHODL 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHODL 33 34
  • 77.52 (n)
lizard
(Anolis carolinensis)
Reptilia CHODL 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chodl 33
  • 71.98 (n)
zebrafish
(Danio rerio)
Actinopterygii chodl 33 34
  • 64.52 (n)
Species where no ortholog for CHODL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHODL Gene

ENSEMBL:
Gene Tree for CHODL (if available)
TreeFam:
Gene Tree for CHODL (if available)

Paralogs for CHODL Gene

Paralogs for CHODL Gene

(1) SIMAP similar genes for CHODL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHODL: view

Variants for CHODL Gene

Sequence variations from dbSNP and Humsavar for CHODL Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000009022 -- 18,137,442(+) CAGGT(A/G)TTTCC intron-variant
rs1000011487 -- 17,958,880(+) GTATT(C/T)TTTCT intron-variant
rs1000015472 -- 18,232,240(+) CGATG(C/T)GCTAA intron-variant
rs1000019997 -- 18,119,849(+) AGTAT(G/T)CAGGT intron-variant
rs1000025080 -- 18,008,383(+) TAAAG(C/T)GCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHODL Gene

Variant ID Type Subtype PubMed ID
dgv100e180 CNV loss 20482838
dgv7769n54 CNV loss 21841781
dgv7770n54 CNV gain+loss 21841781
dgv7771n54 CNV gain+loss 21841781
dgv7772n54 CNV gain+loss 21841781
dgv7773n54 CNV loss 21841781
dgv7774n54 CNV gain+loss 21841781
dgv7775n54 CNV loss 21841781
dgv7776n54 CNV loss 21841781
dgv7777n54 CNV loss 21841781
dgv7778n54 CNV loss 21841781
esv1001519 CNV insertion 20482838
esv1006254 CNV insertion 20482838
esv1372324 CNV deletion 17803354
esv1422720 CNV insertion 17803354
esv1632755 CNV insertion 17803354
esv2421551 CNV deletion 20811451
esv2471706 CNV deletion 19546169
esv2662708 CNV deletion 23128226
esv26906 CNV loss 19812545
esv2723210 CNV deletion 23290073
esv2723211 CNV deletion 23290073
esv2751925 CNV loss 17911159
esv2763238 CNV gain 21179565
esv2763239 CNV loss 21179565
esv28281 CNV loss 19812545
esv2960457 CNV deletion 24192839
esv3054902 CNV deletion 24192839
esv3378916 CNV insertion 20981092
esv3557483 CNV deletion 23714750
esv3557485 CNV deletion 23714750
esv3568116 CNV loss 25503493
esv3646489 CNV loss 21293372
esv3646490 CNV gain 21293372
esv3646494 CNV loss 21293372
esv996017 CNV deletion 20482838
nsv1072167 CNV deletion 25765185
nsv1073117 CNV deletion 25765185
nsv1073118 CNV deletion 25765185
nsv1114268 CNV deletion 24896259
nsv1139008 CNV deletion 24896259
nsv1139009 CNV deletion 24896259
nsv3469 CNV insertion 18451855
nsv459104 CNV loss 19166990
nsv459105 CNV loss 19166990
nsv509791 CNV insertion 20534489
nsv510495 OTHER sequence alteration 20534489
nsv517400 CNV loss 19592680
nsv587086 CNV loss 21841781
nsv587088 CNV gain 21841781
nsv587101 CNV gain+loss 21841781
nsv587105 CNV loss 21841781
nsv587110 CNV gain 21841781
nsv587119 CNV loss 21841781
nsv587135 CNV loss 21841781
nsv587136 CNV loss 21841781
nsv587137 CNV loss 21841781
nsv819544 CNV gain 19587683
nsv828828 CNV loss 20364138

Variation tolerance for CHODL Gene

Residual Variation Intolerance Score: 32.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHODL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHODL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHODL Gene

Disorders for CHODL Gene

Relevant External Links for CHODL

Genetic Association Database (GAD)
CHODL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHODL

No disorders were found for CHODL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHODL Gene

Publications for CHODL Gene

  1. A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. (PMID: 12621022) Weng L … Merregaert J (The Journal of biological chemistry 2003) 3 4 22 60
  2. Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. (PMID: 12079284) Weng L … Merregaert J (Genomics 2002) 2 3 4 60
  3. Antibody-based protein profiling of the human chromosome 21. (PMID: 22042635) Uhlén M … Sivertsson Å (Molecular & cellular proteomics : MCP 2012) 3 4 60
  4. Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin. (PMID: 17606388) Claessens A … Merregaert J (Cell biology international 2007) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for CHODL Gene

Sources for CHODL Gene

Content
Loading form....