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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CHN2 Gene

protein-coding GIFtS: 62
GCID: GC07P029186

chimerin 2

(Previous name: chimerin (chimaerin) 2 )

Explore 11 diseases affiliated with
CHN2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chimerin 2¹ ²		Beta-Chimaerin¹
ARHGAP3¹ ² ³ ⁵		Beta-Chimerin¹
Chimerin (Chimaerin) 2¹ ²		Beta3-Chimaerin¹
BCH² ³		Chimaerin 2²
RHOGAP3² ⁵		Rho-GTPase-Activating Protein 3²
RhoGAP3¹		Beta-Chimerin¹
CHN2-3²		Rho GTPase-Activating Protein 3³

External Ids:	HGNC: 1944¹	Entrez Gene: 1124²	Ensembl: ENSG00000106069⁷	OMIM: 602857⁵	UniProtKB: P52757³

Export aliases for CHN2 gene to outside databases

Previous GC identifers: GC07P028876 GC07P028976 GC07P029007 GC07P029200 GC07P029115

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHN2:

This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP

domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid

binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi

apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased

expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene

is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate

transcriptional splice variants, encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CHIO_HUMAN, P52757

Function: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to

higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors

Gene Wiki entry for CHN2 (Chimerin 2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CHN2 gene promoter:
HFH-3 GR GR-beta RelA FOXI1 AREB6 GR-alpha Meis-1a TGIF Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CHN2 promoter sequence

Search SABiosciences Chromatin IP Primers for CHN2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHN2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15.3 Ensembl cytogenetic band: 7p14.3 HGNC cytogenetic band: 7p15.3

CHN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHN2 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P029186: view genomic region (about GC identifiers)

Start:	29,161,956 bp from pter	End:	29,553,944 bp from pter
Size:	391,989 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 29,284,296-29,604,159

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHIO_HUMAN, P52757 (See protein sequence)

Recommended Name: Beta-chimaerin

Size: 468 amino acids; 53924 Da

Subcellular location: Membrane; Peripheral membrane protein (Potential)

1 PDB 3D structure from and Proteopedia for CHN2:

1XA6 (3D)

Secondary accessions: E9PGE0 Q2M203 Q75MM2

Alternative splicing: 3 isoforms: P52757-1 P52757-2 P52757-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHN2: NX_P52757

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P52757

CHN2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001035025.1 NP_004058.1

ENSEMBL proteins:

ENSP00000462650 ENSP00000409843 ENSP00000441183 ENSP00000222792 ENSP00000386968

ENSP00000396867 ENSP00000398326 ENSP00000444063 ENSP00000400282 ENSP00000438587

ENSP00000440526 ENSP00000442812 ENSP00000386849 ENSP00000406337 ENSP00000387425

ENSP00000394284

Reactome Protein details: P52757
Human Recombinant Protein Products for CHN2:

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	Uscn Proteins for CHN2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005829	cytosol	TAS	--
GO:0016020	membrane	IEA	--

CHN2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHN2 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR020454 DAG/PE-bd

IPR008936 Rho_GTPase_activation_prot

IPR002219 Prot_Kinase_C-like_PE/DAG-bd

IPR000980 SH2

IPR017356 N-chimaerin

Graphical View of Domain Structure for InterPro Entry P52757

ProtoNet protein and cluster: P52757

3 Blocks protein families:

IPB000198 RhoGAP domain

IPB000980 SH2 domain signature

IPB002219 Protein kinase C

UniProtKB/Swiss-Prot: CHIO_HUMAN, P52757

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 Rho-GAP domain

Similarity: Contains 1 SH2 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CHIO_HUMAN, P52757

Function: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to

higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors

Enzyme regulation: In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain,

sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the

cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby

activating the enzyme

Genatlas biochemistry entry for CHN2:

chimerin beta-2,GTPase activating protein for the ras-related p21rac,DAG (diacylglycerol) receptor,expressed in

cerebellum,homolog to CHN1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005070	SH3/SH2 adaptor activity	TAS	8175705
GO:0005096	GTPase activator activity	IEA	--
GO:0030675	Rac GTPase activator activity	--	--
GO:0046872	metal ion binding	IEA	--

CHN2 for ontologies About GeneDecksing

Phenotypes:
2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Chn2):

cellular

nervous system

CHN2 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CHN2

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		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate CHN2 (see all 29):
		hsa-miR-217 hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-miR-429 hsa-miR-202 hsa-miR-302e hsa-miR-374c

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHN2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

G-protein signaling Regulation of RAC1 activity

	G-protein signaling Regulation of RAC1 activity	1.00			G-protein signaling Regulation of CDC42 activity	0.25
	G-protein signaling_Regulation of RAC1 activity	0.88			G-protein signaling_Regulation of CDC42 activity	0.25

Cell death signalling via NRAGE, NRIF and NADE

Rho GTPase cycle

0.25

Signaling by Rho GTPases

0.25

Neuroscience

Neuroscience

1.00

Cytoskeletal Signaling

Cytoskeletal Signaling

1.00

G12-G13 in Cellular Signaling

G12-G13 in Cellular Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CHN2

	G-protein signaling Regulation of CDC42 activity
	G-protein signaling Regulation of RAC1 activity

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CHN2

	RhoA Pathway
	G12-G13 in Cellular Signaling
	RhoGDI Pathway

2 Cell Signaling Technology (CST) Pathways for CHN2

	Neuroscience
	Cytoskeletal Signaling

2 GeneGo (Thomson Reuters) Pathways for CHN2

	G-protein signaling Regulation of RAC1 activity
	G-protein signaling Regulation of CDC42 activity

2 BioSystems Pathways for CHN2

	Regulation of RAC1 activity
	ErbB1 downstream signaling

3 Reactome Pathways for CHN2

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

CHN2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CHN2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/92 Interacting proteins for CHN2 (P52757^{2, 3} ENSP00000222792⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 92)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BAG6	P46379²^,³	MINT-63864 I2D: score=5
NCK1	P16333²^,³	MINT-19584 I2D: score=2
RAC1	P63000²^,³, ENSP00000348461⁴	MINT-2490402 MINT-2490642 MINT-2490281 MINT-2489914 I2D: score=2 STRING: ENSP00000348461
ERBB3	P21860²^,³, ENSP00000267101⁴	MINT-74490 I2D: score=2 STRING: ENSP00000267101
EIF3C	Q99613³	I2D: score=1

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001675	acrosome assembly	--	--
GO:0007165	signal transduction	--	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0032855	positive regulation of Rac GTPase activity	--	--
GO:0035556	intracellular signal transduction	--	--

CHN2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHN2

10/843 HMDB Compounds for CHN2 (see all 843) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--
DG(14:0/18:2(9Z,12Z)/0:0)	DAG(14:0/18:2n6) (see all 15)	--	--
DG(14:0/18:3(6Z,9Z,12Z)/0:0)	Diacylglycerol(14:0/18:3n6) (see all 16)	--	--

Search CenterWatch for drugs/clinical trials and news about CHN2 / CHIO

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHN2 gene (2 alternative transcripts):

NM_001039936.1 NM_004067.2

Unigene Clusters for CHN2:

Chimerin 2

Hs.654611 [show with all ESTs], Hs.654753 [show with all ESTs], Hs.663145 [show with all ESTs]

Unigene Representative Sequences: AK126784, AK123927, CB155970

18/33 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 33):

ENST00000582692 ENST00000578605 ENST00000443025 ENST00000588769 ENST00000423511

ENST00000439384 ENST00000461824 ENST00000474070 ENST00000470261 ENST00000222792(uc011jzs.2 uc003szz.3 uc010kva.3 uc010kvb.3 uc010kvc.3 uc011jzt.2 uc010kvd.3 uc011jzu.2)

ENST00000409350 ENST00000409964 ENST00000409922 ENST00000412536 ENST00000478128

ENST00000482820 ENST00000483081 ENST00000491856

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		hsa-miR-217 hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-miR-429 hsa-miR-202 hsa-miR-302e hsa-miR-374c

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Additional cDNA sequence: AF147327.1

13 DOTS entries:

DT.99933073 DT.75181758 DT.92466313 DT.85104379 DT.91937639 DT.95154187 DT.92056165 DT.100822444

DT.40290942 DT.99951317 DT.100701861 DT.121109341 DT.100738101

24/128 AceView cDNA sequences (see all 128):

N64335 AI017379 F01480 AI301462 BF431785 BU743151 N64330 AI241398

AW955719 F05503 AI824491 F01481 F11279 F01769 BI830814 AA743572

BQ446523 AA910911 AW055148 AI453797 AA741256 AA910909 AW026309 AA680076

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CHN2 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b	·	15c
SP1:															-		-
SP2:
SP3:
SP4:
SP5:			-		-

ECgene alternative splicing isoforms for CHN2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHN2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAATGCCAA

About this image

CHN2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

Mature Horizontal Cells

Horizontal, Retina

Eye

Inner Nuclear Layer

nGnG Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Midbrain dopaminergic-like neurons (Generation of midbra...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See CHN2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHN2

SOURCE GeneReport for Unigene clusters: Hs.654611 Hs.654753 Hs.663145

UniProtKB/Swiss-Prot: CHIO_HUMAN, P52757

Tissue specificity: Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the

kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade

astrocytomas

SABiosciences Custom PCR Arrays for CHN2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHN2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHN2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CHN2 gene from 5/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CHN2¹	chimerin (chimaerin) 2	83.4(n) 93.59(a)		428437 XM_425997.3 XP_425997.2
lizard (Anolis carolinensis)	Reptilia	CHN2⁶	--	90(a)	1 ↔ 1	GL343275.1(3939-107921)
zebrafish (Danio rerio)	Actinopterygii	chn2¹	chimerin (chimaerin) 2	71.32(n) 80.32(a)		570999 XM_694550.5 XP_699642.5
fruit fly (Drosophila melanogaster)	Insecta	RhoGAP5A³	diacylglycerol binding	39(a)		5A8 --
worm (Caenorhabditis elegans)	Secernentea	BE0003N10.2³ chin-1¹	Protein CHIN-1¹	43(a)³ 51.52(n)¹ 43.55(a)¹		III(1108090-1109028)³ 175268¹ NM_064922.4¹ NP_497323.3¹

ENSEMBL Gene Tree for CHN2 (if available)
TreeFam Gene Tree for CHN2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CHN2 gene

HMHA1² ARHGAP21² ARHGAP27² ARHGAP10² ARHGAP23² ARHGAP9² ARHGAP29² ARHGAP26²

CHN1² ARHGAP15² ARHGAP12² OPHN1² GMIP² ARHGAP42²

18/28 SIMAP similar genes for CHN2 using alignment to 30 protein entries: CHIO_HUMAN (see all proteins) (see all similar genes):

LOC401318 CHN2-3 CHN1 ARHGAP44 OPHN1 PRKD1

ARHGAP10 ARHGAP26 ARHGAP12 SH3BP1 ARHGAP42 ARHGAP5

ARHGAP24 ARHGAP31 ARHGAP27 ARHGAP1 SRGAP2 MYO9A

CHN2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs180944382^1,2		--	29232290(+)	`ATAGCA/GTCTTA`	1	--	us2k¹		0	--	--	--	--
rs150552675^1,2		--	29232744(+)	`CCATAC/TAGTTG`	1	--	us2k¹		0	--	--	--	--
rs144828023^1,2		--	29232824(+)	`TTTTT-/AAAAAA`	1	--	us2k¹		0	--	--	--	--
rs139586306^1,2		--	29232928(+)	`ACTGTG/TATTAT`	1	--	us2k¹		0	--	--	--	--
rs39049^1,2	C,A,H	--	29232964(+)	`TAGGTG/CCTTGG`	1	--	us2k¹ tfbs³		11		MN NA WA CSA EA	438
rs245923^1,2	C,F,H	--	29232999(+)	`CTGCTG/ATTCTG`	1	--	us2k¹		16		MN NS EA WA NA	2520
rs191993230^1,2		--	29233111(+)	`AGAGTA/GCTTTC`	1	--	us2k¹		0	--	--	--	--
rs183470399^1,2		--	29233173(+)	`TCACAG/TTTTTC`	1	--	us2k¹		0	--	--	--	--
rs186270119^1,2		--	29233316(+)	`CTCGAA/GTCTCT`	1	--	us2k¹		0	--	--	--	--
rs3807599^1,2	C,F,H	--	29233367(+)	`CAGTCG/AGACCT`	1	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for CHN2 (29161956 - 29411956 bp, first 250kb of CHN2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CHN2
2 CNVs: 99905 6540
4 Indels: 11297 40965 41978 47335

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CHN2 for disorders           About GeneDecksing

OMIM gene information: 602857    OMIM disorders: --

11 diseases for CHN2:    About MalaCards

diffuse large b-cell lymphoma schizophrenia b-cell lymphomas sleeping sickness

insulin resistance diabetic retinopathy malignant glioma nephropathy

spasticity astrocytoma breast cancer

Human Genome Epidemiology (HuGE) Navigator: CHN2 (7 documents)

Export disorders for CHN2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CHN2 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with CHN2)

Utopia: connect your pdf to the dynamic
world of online information

Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras- related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain. (PubMed id 8175705)^{1, 2, 3, 9} Leung T.... Lim L. (1994)
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin. (PubMed id 15507211)^{1, 2} Canagarajah B....Hurley J.H. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma. (PubMed id 7614486)^{1, 2} Yuan S.... Williams B.R.G. (1995)
Severe insulin resistance and intrauterine growth def iciency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism. (PubMed id 19720790)^{1, 9} Suliman S.G....Gloyn A.L. (2009)
CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients. (PubMed id 21911749)¹ Hu C....Jia W. (2011)
Generalist genes analysis of DNA markers associated w ith mathematical ability and disability reveals shared influence across ages an d abilities. (PubMed id 20602751)¹ Docherty S.J....Plomin R. (2010)
A Bayesian approach to genetic association studies wi th family-based designs. (PubMed id 20818722)¹ Naylor M.G....Lange C. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1124	HGNC: 1944	AceView: CHN2	Ensembl:ENSG00000106069	euGenes: HUgn1124
ECgene: CHN2	H-InvDB: CHN2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CHN2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CHN2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CHN2 gene:
Search GeneIP for patents involving CHN2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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