Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHN2 Gene

Aliases for CHN2 Gene

  • Chimerin 2 2 3
  • ARHGAP3 3 4 6
  • Chimerin (Chimaerin) 2 2 3
  • Beta-Chimerin 3 4
  • RHOGAP3 3 6
  • BCH 3 4
  • Rho-GTPase-Activating Protein 3 3
  • Rho GTPase-Activating Protein 3 4
  • Chimerin, Testis-Specific 3
  • Chimerin, Beta-2 3
  • Beta3-Chimaerin 3
  • Beta-Chimaerin 3
  • Beta Chimerin 2
  • Chimaerin 2 2
  • CHN2-3 3

External Ids for CHN2 Gene

Previous GeneCards Identifiers for CHN2 Gene

  • GC07P028876
  • GC07P028976
  • GC07P029007
  • GC07P029200
  • GC07P029115

Summaries for CHN2 Gene

Entrez Gene Summary for CHN2 Gene

  • This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that contains a phorbol-ester/diacylglycerol (DAG)-type zinc finger, a Rho-GAP domain, and an SH2 domain. The encoded protein translocates from the cytosol to the Golgi apparatus membrane upon binding by diacylglycerol (DAG). Activity of this protein is important in cell proliferation and migration, and expression changes in this gene have been detected in cancers. A mutation in this gene has also been associated with schizophrenia in men. Alternative transcript splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for CHN2 Gene

CHN2 (Chimerin 2) is a Protein Coding gene. Diseases associated with CHN2 include schizophrenia. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and SH3/SH2 adaptor activity. An important paralog of this gene is CHN1.

UniProtKB/Swiss-Prot for CHN2 Gene

  • GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors

Gene Wiki entry for CHN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHN2 Gene

Genomics for CHN2 Gene

Regulatory Elements for CHN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHN2 Gene

Start:
29,122,274 bp from pter
End:
29,514,328 bp from pter
Size:
392,055 bases
Orientation:
Plus strand

Genomic View for CHN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHN2 Gene

Proteins for CHN2 Gene

  • Protein details for CHN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52757-CHIO_HUMAN
    Recommended name:
    Beta-chimaerin
    Protein Accession:
    P52757
    Secondary Accessions:
    • A4D1A2
    • B3VCF1
    • B3VCF2
    • B3VCF3
    • B3VCF7
    • B3VCG1
    • C9J7B0
    • E9PGE0
    • F8QPL9
    • Q2M203
    • Q75MM2

    Protein attributes for CHN2 Gene

    Size:
    468 amino acids
    Molecular mass:
    53924 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CHN2 Gene

    Alternative splice isoforms for CHN2 Gene

neXtProt entry for CHN2 Gene

Proteomics data for CHN2 Gene at MOPED

Post-translational modifications for CHN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CHN2 Gene

Domains for CHN2 Gene

Gene Families for CHN2 Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins
  • SH2D :SH2 domain containing

Graphical View of Domain Structure for InterPro Entry

P52757

UniProtKB/Swiss-Prot:

CHIO_HUMAN :
  • P52757
Domain:
  • Contains 1 Rho-GAP domain.
  • Contains 1 SH2 domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with CHN2: view

Function for CHN2 Gene

Molecular function for CHN2 Gene

GENATLAS Biochemistry: chimerin beta-2,GTPase activating protein for the ras-related p21rac,DAG (diacylglycerol) receptor,expressed in cerebellum,homolog to CHN1
UniProtKB/Swiss-Prot EnzymeRegulation: In the inactive state, the N terminus protrudes into the active site of the Rho-GAP domain, sterically blocking Rac binding. Phospholipid binding to the Phorbol-ester/DAG-type zinc-finger/C1 domain triggers the cooperative dissociation of these interactions, allowing the N-terminus to move out of the active site and thereby activating the enzyme.
UniProtKB/Swiss-Prot Function: GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors

Gene Ontology (GO) - Molecular Function for CHN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005070 SH3/SH2 adaptor activity TAS 8175705
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 16628218
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CHN2: view

Phenotypes for CHN2 Gene

genes like me logo Genes that share phenotypes with CHN2: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHN2 Gene

Localization for CHN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHN2 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHN2 Gene COMPARTMENTS Subcellular localization image for CHN2 gene
Compartment Confidence
cytosol 4
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CHN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with CHN2: view

Pathways for CHN2 Gene

genes like me logo Genes that share pathways with CHN2: view

Pathways by source for CHN2 Gene

2 Cell Signaling Technology pathways for CHN2 Gene
2 BioSystems pathways for CHN2 Gene

Gene Ontology (GO) - Biological Process for CHN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0009967 positive regulation of signal transduction TAS 8175705
GO:0035556 intracellular signal transduction --
GO:0043547 positive regulation of GTPase activity TAS 7614486
genes like me logo Genes that share ontologies with CHN2: view

Compounds for CHN2 Gene

(843) HMDB Compounds for CHN2 Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with CHN2: view

Transcripts for CHN2 Gene

Unigene Clusters for CHN2 Gene

Chimerin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHN2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHN2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - -
SP2:
SP3:
SP4:
SP5: - -
SP6: -

Relevant External Links for CHN2 Gene

GeneLoc Exon Structure for
CHN2
ECgene alternative splicing isoforms for
CHN2

Expression for CHN2 Gene

mRNA expression in normal human tissues for CHN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHN2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (13.6) and Brain - Cerebellum (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHN2 Gene

SOURCE GeneReport for Unigene cluster for CHN2 Gene Hs.654611

mRNA Expression by UniProt/SwissProt for CHN2 Gene

P52757-CHIO_HUMAN
Tissue specificity: Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas
genes like me logo Genes that share expressions with CHN2: view

In Situ Assay Products

Orthologs for CHN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHN2 35
  • 99.22 (n)
  • 100 (a)
CHN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHN2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHN2 35
  • 92.09 (n)
  • 97.44 (a)
CHN2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chn2 35
  • 90.38 (n)
  • 97.65 (a)
Chn2 16
Chn2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHN2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHN2 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHN2 35
  • 83.4 (n)
  • 93.59 (a)
CHN2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHN2 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chn2 35
  • 77.3 (n)
  • 83.94 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11065 35
zebrafish
(Danio rerio)
Actinopterygii chn2 35
  • 71.9 (n)
  • 81.08 (a)
chn2 36
  • 81 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGAP5A 36
  • 37 (a)
OneToMany
RhoGAP5A 37
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea chin-1 35
  • 51.65 (n)
  • 43.43 (a)
chin-1 36
  • 39 (a)
OneToMany
BE0003N10.2 37
  • 43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for CHN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHN2 Gene

ENSEMBL:
Gene Tree for CHN2 (if available)
TreeFam:
Gene Tree for CHN2 (if available)

Paralogs for CHN2 Gene

genes like me logo Genes that share paralogs with CHN2: view

Variants for CHN2 Gene

Sequence variations from dbSNP and Humsavar for CHN2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs446 -- 29,312,779(+) CCCAA(A/G)TAATG intron-variant
rs12611 -- 29,513,161(+) TGTAT(C/T)TTTAT utr-variant-3-prime, nc-transcript-variant
rs28467 -- 29,236,820(+) gctca(C/T)ggccc intron-variant
rs39047 -- 29,188,934(+) GATAT(A/G)GTTTT intron-variant
rs39048 -- 29,192,408(+) AAACA(G/T)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHN2 Gene

Variant ID Type Subtype PubMed ID
nsv5680 CNV Insertion 18451855
esv2675235 CNV Deletion 23128226
esv2734182 CNV Deletion 23290073
nsv887895 CNV Gain 21882294
esv2194510 CNV Deletion 18987734
nsv5681 CNV Loss 18451855
nsv830934 CNV Gain 17160897
esv2734183 CNV Deletion 23290073
esv270445 CNV Insertion 20981092
esv2659047 CNV Deletion 23128226
esv273752 CNV Insertion 20981092
esv2526582 CNV Deletion 19546169
esv2028870 CNV Deletion 18987734
esv4539 CNV Deletion 18987735
esv2734185 CNV Deletion 23290073
esv270920 CNV Insertion 20981092
esv33032 CNV Gain 17666407
nsv366043 CNV Loss 16902084

Relevant External Links for CHN2 Gene

HapMap Linkage Disequilibrium report
CHN2
Human Gene Mutation Database (HGMD)
CHN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHN2 Gene

Disorders for CHN2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CHN2 Gene including...

Search for CHN2 Gene in MalaCards »

Relevant External Links for CHN2

Genetic Association Database (GAD)
CHN2
Human Genome Epidemiology (HuGE) Navigator
CHN2
genes like me logo Genes that share disorders with CHN2: view

No data available for UniProtKB/Swiss-Prot for CHN2 Gene

Publications for CHN2 Gene

  1. Cerebellar beta 2-chimaerin, a GTPase-activating protein for p21 ras- related rac is specifically expressed in granule cells and has a unique N-terminal SH2 domain. (PMID: 8175705) Leung T. … Lim L. (J. Biol. Chem. 1994) 2 3 4 23
  2. Severe insulin resistance and intrauterine growth deficiency associated with haploinsufficiency for INSR and CHN2: new insights into synergistic pathways involved in growth and metabolism. (PMID: 19720790) Suliman S.G. … Gloyn A.L. (Diabetes 2009) 3 23
  3. Identification and characterization of human beta 2-chimaerin: association with malignant transformation in astrocytoma. (PMID: 7614486) Yuan S. … Williams B.R.G. (Cancer Res. 1995) 3 4
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4

Products for CHN2 Gene

Sources for CHN2 Gene

Back to Top

Content