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Aliases for CHMP7 Gene

Aliases for CHMP7 Gene

  • Charged Multivesicular Body Protein 7 2 3 5
  • Chromatin-Modifying Protein 7 4
  • CHMP Family, Member 7 2

External Ids for CHMP7 Gene

Previous GeneCards Identifiers for CHMP7 Gene

  • GC08P023027
  • GC08P023157
  • GC08P021647
  • GC08P023101

Summaries for CHMP7 Gene

GeneCards Summary for CHMP7 Gene

CHMP7 (Charged Multivesicular Body Protein 7) is a Protein Coding gene. Among its related pathways are Infectious disease and HIV Life Cycle. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for CHMP7 Gene

  • Plays a role in the endosomal sorting pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP7 Gene

Genomics for CHMP7 Gene

Regulatory Elements for CHMP7 Gene

Enhancers for CHMP7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHMP7 on UCSC Golden Path with GeneCards custom track

Promoters for CHMP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHMP7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHMP7 Gene

23,243,637 bp from pter
23,262,000 bp from pter
18,364 bases
Plus strand

Genomic View for CHMP7 Gene

Genes around CHMP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHMP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP7 Gene

Proteins for CHMP7 Gene

  • Protein details for CHMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Charged multivesicular body protein 7
    Protein Accession:
    Secondary Accessions:
    • B2RDT3
    • B4DKJ6
    • D3DSS1
    • Q8NDM1
    • Q9BT50

    Protein attributes for CHMP7 Gene

    453 amino acids
    Molecular mass:
    50911 Da
    Quaternary structure:
    • Interacts with CHMP4B, but not with VPS25.

    Alternative splice isoforms for CHMP7 Gene


neXtProt entry for CHMP7 Gene

Proteomics data for CHMP7 Gene at MOPED

Post-translational modifications for CHMP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHMP7 Gene

No data available for DME Specific Peptides for CHMP7 Gene

Domains & Families for CHMP7 Gene

Protein Domains for CHMP7 Gene

Suggested Antigen Peptide Sequences for CHMP7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SNF7 family.
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP7: view

Function for CHMP7 Gene

Molecular function for CHMP7 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the endosomal sorting pathway.
genes like me logo Genes that share phenotypes with CHMP7: view

Animal Model Products

miRNA for CHMP7 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHMP7 Gene

Localization for CHMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP7 Gene

Cytoplasm. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area.

Subcellular locations from

Jensen Localization Image for CHMP7 Gene COMPARTMENTS Subcellular localization image for CHMP7 gene
Compartment Confidence
cytosol 5
endosome 5
nucleus 3

Gene Ontology (GO) - Cellular Components for CHMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000815 ESCRT III complex IDA 16856878
genes like me logo Genes that share ontologies with CHMP7: view

Pathways & Interactions for CHMP7 Gene

genes like me logo Genes that share pathways with CHMP7: view

Pathways by source for CHMP7 Gene

Gene Ontology (GO) - Biological Process for CHMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
GO:0007080 mitotic metaphase plate congression IMP 20616062
GO:0010458 exit from mitosis IMP 26040712
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with CHMP7: view

No data available for SIGNOR curated interactions for CHMP7 Gene

Drugs & Compounds for CHMP7 Gene

No Compound Related Data Available

Transcripts for CHMP7 Gene

Unigene Clusters for CHMP7 Gene

Charged multivesicular body protein 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - -
SP9: -

Relevant External Links for CHMP7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHMP7 Gene

mRNA expression in normal human tissues for CHMP7 Gene

Protein differential expression in normal tissues from HIPED for CHMP7 Gene

This gene is overexpressed in Lymph node (17.9), Peripheral blood mononuclear cells (17.4), and Blymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHMP7 Gene

SOURCE GeneReport for Unigene cluster for CHMP7 Gene Hs.5019

genes like me logo Genes that share expression patterns with CHMP7: view

Protein tissue co-expression partners for CHMP7 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHMP7 Gene

Orthologs for CHMP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHMP7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHMP7 35
  • 91.85 (n)
  • 96.89 (a)
CHMP7 36
  • 97 (a)
(Canis familiaris)
Mammalia CHMP7 35
  • 92.44 (n)
  • 94.22 (a)
CHMP7 36
  • 95 (a)
(Mus musculus)
Mammalia Chmp7 35
  • 90.15 (n)
  • 95.78 (a)
Chmp7 16
Chmp7 36
  • 96 (a)
(Pan troglodytes)
Mammalia CHMP7 35
  • 99.63 (n)
  • 99.56 (a)
CHMP7 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Chmp7 35
  • 90.07 (n)
  • 96.67 (a)
(Monodelphis domestica)
Mammalia CHMP7 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia CHMP7 36
  • 90 (a)
(Gallus gallus)
Aves CHMP7 35
  • 74.81 (n)
  • 78.31 (a)
CHMP7 36
  • 77 (a)
(Anolis carolinensis)
Reptilia CHMP7 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp7 35
  • 56.5 (n)
  • 51.99 (a)
(Danio rerio)
Actinopterygii chmp7 35
  • 58.7 (n)
  • 55.5 (a)
zgc73300 35
chmp7 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012459 35
  • 41.62 (n)
  • 30.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5498 35
  • 39.76 (n)
  • 25.61 (a)
CG5498 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea T24B8.2 35
  • 41.96 (n)
  • 28.53 (a)
T24B8.2 36
  • 25 (a)
Species with no ortholog for CHMP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHMP7 Gene

Gene Tree for CHMP7 (if available)
Gene Tree for CHMP7 (if available)

Paralogs for CHMP7 Gene

(1) SIMAP similar genes for CHMP7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHMP7: view

No data available for Paralogs for CHMP7 Gene

Variants for CHMP7 Gene

Sequence variations from dbSNP and Humsavar for CHMP7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2280934 -- 23,249,152(-) TCCAG(C/T)CTCTA intron-variant
rs2294123 -- 23,246,682(-) CAGCC(A/C)CGGCA utr-variant-5-prime
rs2294124 -- 23,260,649(-) ACACA(C/G/T)CCAGC utr-variant-3-prime
rs2294125 -- 23,260,130(-) AAAAG(A/G)CAACA intron-variant
rs10086496 -- 23,243,425(+) CCTAA(A/T)TGCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHMP7 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
esv2736756 CNV Deletion 23290073

Variation tolerance for CHMP7 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CHMP7 Gene

Disorders for CHMP7 Gene

Relevant External Links for CHMP7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CHMP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHMP7 Gene

Publications for CHMP7 Gene

  1. CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway. (PMID: 16856878) Horii M. … Maki M. (Biochem. J. 2006) 2 3 4 67
  2. Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. (PMID: 26040712) Vietri M. … Stenmark H. (Nature 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3

Products for CHMP7 Gene

Sources for CHMP7 Gene