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CHMP7 Gene

protein-coding   GIFtS: 55
GCID: GC08P023101

Charged Multivesicular Body Protein 7

(Previous names: CHMP family, member 7)
  Search for CHMP7
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Charged Multivesicular Body Protein 71 2
CHMP Family, Member 71 2
Chromatin-Modifying Protein 72 3

External Ids:    HGNC: 284391   Entrez Gene: 917822   Ensembl: ENSG000001474577   OMIM: 6111305   UniProtKB: Q8WUX93   

Export aliases for CHMP7 gene to outside databases

Previous GC identifers: GC08P023027 GC08P023157 GC08P021647


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CHMP7 Gene:
CHMP7 (charged multivesicular body protein 7) is a protein-coding gene. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot: CHMP7_HUMAN, Q8WUX9
Function: Plays a role in the endosomal sorting pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHMP7 gene promoter:
         STAT1   Sp1   POU2F1a   ATF-2   STAT1beta   c-Jun   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHMP7 promoter sequence
   Search Chromatin IP Primers for CHMP7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHMP7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p21.3   Ensembl cytogenetic band:  8p21.3   HGNC cytogenetic band: 8p21.2

CHMP7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP7 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P023101:  view genomic region     (about GC identifiers)

Start:
23,101,150 bp from pter      End:
23,119,512 bp from pter
Size:
18,363 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHMP7_HUMAN, Q8WUX9 (See protein sequence)
Recommended Name: Charged multivesicular body protein 7  
Size: 453 amino acids; 50911 Da
Subunit: Interacts with CHMP4B, but not with VPS25
Secondary accessions: B2RDT3 D3DSS1 Q8NDM1 Q9BT50

Explore the universe of human proteins at neXtProt for CHMP7: NX_Q8WUX9

Explore proteomics data for CHMP7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CHMP7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689485.1  
    ENSEMBL proteins: 
     ENSP00000380794   ENSP00000428233   ENSP00000430321   ENSP00000430661   ENSP00000427948  
     ENSP00000324491  
    Reactome Protein details: Q8WUX9

    CHMP7 Human Recombinant Protein Products:

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    OriGene Custom Protein Services for CHMP7
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    Novus Biologicals CHMP7 Protein
    Novus Biologicals CHMP7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHMP7

     
    Search eBioscience for Proteins for CHMP7 

    CHMP7 Antibody Products:

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    CHMP7 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHMP7
    Cloud-Clone Corp. CLIAs for CHMP7
    Search eBioscience for ELISAs for CHMP7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHMP: Charged multivesicular body proteins

    1 InterPro protein domain:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry Q8WUX9

    ProtoNet protein and cluster: Q8WUX9

    1 Blocks protein domain: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHMP7_HUMAN, Q8WUX9
    Similarity: Belongs to the SNF7 family


    Find genes that share domains with CHMP7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHMP7_HUMAN, Q8WUX9
    Function: Plays a role in the endosomal sorting pathway

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008565protein transporter activity IMP16856878
         
    Find genes that share ontologies with CHMP7           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CHMP7:
     Decreased viability with pacli  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHMP7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHMP7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHMP7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHMP7

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHMP7:
    hsa-mir-26b-5p (MIRT030249), hsa-mir-15b-5p (MIRT046411), hsa-mir-505-5p (MIRT037936), hsa-mir-484 (MIRT042391)

    Block miRNA regulation of human, mouse, rat CHMP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHMP7 (see all 41):
    hsa-miR-1245 hsa-miR-25 hsa-miR-219-5p hsa-miR-449a hsa-miR-508-3p hsa-miR-877* hsa-miR-149 hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHMP7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHMP7
    Predesigned siRNA for gene silencing in human, mouse, rat CHMP7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHMP7

    Clone
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    OriGene clones in human, mouse for CHMP7 (see all 7)
    OriGene ORF clones in mouse, rat for CHMP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHMP7 (NM_152272)
    Sino Biological Human cDNA Clone for CHMP7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CHMP7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP7

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11970) for CHMP7 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHMP7_HUMAN, Q8WUX9: Cytoplasm. Note=Diffused localization, with some punctate distribution, especially in the
    perinuclear area
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol4
    nucleus4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000815ESCRT III complex IDA16856878
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with CHMP7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHMP7 About    
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease


    Find genes that share SuperPaths with CHMP7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for CHMP7
        Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for CHMP7):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHMP7
    Interactions:

        Search GeneGlobe Interaction Network for CHMP7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHMP7 (Q8WUX92, 3 ENSP000003244914) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAFAH1B3Q151022, 3, ENSP000002628904MINT-67473 I2D: score=5 STRING: ENSP00000262890
    USP8P408183, ENSP000003022394I2D: score=1 STRING: ENSP00000302239
    CHMP2AENSP000003104404STRING: ENSP00000310440
    CHMP2BENSP000002637804STRING: ENSP00000263780
    CHMP3ENSP000002638564STRING: ENSP00000263856
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport ----
    GO:0016032viral process TAS--
    GO:0016197endosomal transport TAS--
    GO:0019058viral life cycle TAS--
    GO:0045324late endosome to vacuole transport IMP16856878

    Find genes that share ontologies with CHMP7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHMP7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHMP7 gene: 
    NM_152272.3  

    Unigene Cluster for CHMP7:

    Charged multivesicular body protein 7
    Hs.5019  [show with all ESTs]
    Unigene Representative Sequence: NM_152272
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397677(uc011kzs.1 uc003xdc.2) ENST00000519414 ENST00000517325
    ENST00000519984 ENST00000519529 ENST00000519503 ENST00000523091(uc003xde.2)
    ENST00000520102 ENST00000521656 ENST00000313219(uc003xdd.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHMP7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHMP7 (see all 41):
    hsa-miR-1245 hsa-miR-25 hsa-miR-219-5p hsa-miR-449a hsa-miR-508-3p hsa-miR-877* hsa-miR-149 hsa-miR-654-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHMP7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHMP7
    Predesigned siRNA for gene silencing in human, mouse, rat CHMP7
    Clone
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    OriGene clones in human, mouse for CHMP7 (see all 7)
    OriGene ORF clones in mouse, rat for CHMP7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHMP7 (NM_152272)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHMP7
    OriGene qSTAR qPCR primer pairs in human, mouse for CHMP7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHMP7
      QuantiTect SYBR Green Assays in human, mouse, rat CHMP7
      QuantiFast Probe-based Assays in human, mouse, rat CHMP7
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11970) for CHMP7 

    Additional mRNA sequence: 

    AK021776.1 AK092500.1 AK097202.1 AK296592.1 AK315664.1 AL832313.1 AL833843.1 BC004344.1 
    BC019110.1 BC042050.1 

    10 DOTS entries:

    DT.118639  DT.100035959  DT.102824867  DT.100780519  DT.100788013  DT.120628553  DT.120628554  DT.40106668 
    DT.92013970  DT.95240489 

    Selected AceView cDNA sequences (see all 312):

    AI889945 AW192273 BX483733 BQ773943 CB321664 AW474430 BU678160 AI566509 
    CD367272 AW070822 AI651818 CB157960 BM707351 BQ049217 CN480076 AI356861 
    AV709347 CK725109 AI206493 AI269831 AA631025 BE396731 AI869748 AX747573 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHMP7 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                                    -           -     -                                                         
    SP2:                                                              -     -           -     -                                                         
    SP3:                                                                                                                                -               
    SP4:                                                                    -                 -                                                         
    SP5:                                                                    -     -     -     -                                                         


    ECgene alternative splicing isoforms for CHMP7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHMP7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTAACTTA
    CHMP7 Expression
    About this image

    CHMP7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHMP7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5019
        Custom PCR Arrays for CHMP7
    Primer
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    OriGene qPCR primer pairs and template standards for CHMP7
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    QuantiTect SYBR Green Assays in human, mouse, rat CHMP7
    QuantiFast Probe-based Assays in human, mouse, rat CHMP7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHMP7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chmp71 , 5 charged multivesicular body protein 71, 5 90.15(n)1
    95.78(a)1
      14 (36.09 cM)5
    1055131  NM_134078.41  NP_598839.21 
     697169795 
    chicken
    (Gallus gallus)
    Aves CHMP71 charged multivesicular body protein 7 74.81(n)
    78.31(a)
      419535  NM_001006306.2  NP_001006306.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHMP76
    charged multivesicular body protein 7
    77(a)
    1 ↔ 1
    GL343679.1(57814-65600)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC055997.12   -- 73.82(n)    BC055997.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc733002 hypothetical protein MGC73300 74.43(n)   393754  BC059625.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54981 CG5498 39.76(n)
    25.61(a)
      40250  NM_168850.3  NP_730525.2 
    worm
    (Caenorhabditis elegans)
    Secernentea T24B8.21 T24B8.2 41.96(n)
    28.53(a)
      174442  NM_063532.5  NP_495933.1 


    ENSEMBL Gene Tree for CHMP7 (if available)
    TreeFam Gene Tree for CHMP7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHMP7 gene
    1 SIMAP similar gene for CHMP7 using alignment to 5 protein entries:     CHMP7_HUMAN (see all proteins):
    ETFA

    Find genes that share paralogs with CHMP7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHMP7 (see all 576)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1808651771,2
    --23099165(+) GCCACC/TGCGCC 1 -- us2k10--------
    rs1859573551,2
    --23099169(+) CCGCGA/CCGGAC 1 -- us2k10--------
    rs712086011,2
    C--23099240(+) TTTTTT/-GAGAC 1 -- us2k12Minor allele frequency- -:0.25NA CSA 4
    rs1896813331,2
    --23099394(+) ACACTC/TGGCTA 1 -- us2k10--------
    rs132630751,2
    C,F,A--23099475(+) gatccT/Gcccgc 1 -- us2k14Minor allele frequency- G:0.38NA CSA 8
    rs132654081,2
    C,F,A--23099511(+) acaggT/Catgag 1 -- us2k14Minor allele frequency- C:0.38NA 8
    rs1812235661,2
    C--23099512(+) CAGGCA/GTGAGC 1 -- us2k10--------
    rs1869253801,2
    --23099530(+) CCCAGC/TCCAAG 1 -- us2k10--------
    rs1906045301,2
    --23099532(+) CAGCCC/TAAGAT 1 -- us2k10--------
    rs1378817471,2
    --23099576(+) TCAACC/TTAATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHMP7 (23101150 - 23119512 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHMP7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736756CNV Deletion23290073
    essv19243CNV CNV17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611130    OMIM disorders: --


    Find genes that share disorders with CHMP7           About GenesLikeMe

    Genetic Association Database (GAD): CHMP7
    Human Genome Epidemiology (HuGE) Navigator: CHMP7 (1 document)

    Export disorders for CHMP7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHMP7 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with CHMP7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway. (PubMed id 16856878)1, 2, 3 Horii M....Maki M. (Biochem. J. 2006)
    2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 91782 HGNC: 28439 AceView: MGC29816 Ensembl:ENSG00000147457 euGenes: HUgn91782
    ECgene: CHMP7 Kegg: 91782 H-InvDB: CHMP7

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHMP7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHMP7 gene:
    Search GeneIP for patents involving CHMP7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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