Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHMP7 Gene

Aliases for CHMP7 Gene

  • Charged Multivesicular Body Protein 7 2 3
  • Chromatin-Modifying Protein 7 4
  • CHMP Family, Member 7 2

External Ids for CHMP7 Gene

Previous GeneCards Identifiers for CHMP7 Gene

  • GC08P023027
  • GC08P023157
  • GC08P021647
  • GC08P023101

Summaries for CHMP7 Gene

GeneCards Summary for CHMP7 Gene

CHMP7 (Charged Multivesicular Body Protein 7) is a Protein Coding gene. Among its related pathways are Disease and Endocytosis. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for CHMP7 Gene

  • Plays a role in the endosomal sorting pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP7 Gene

Genomics for CHMP7 Gene

Regulatory Elements for CHMP7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHMP7 Gene

Start:
23,243,637 bp from pter
End:
23,262,000 bp from pter
Size:
18,364 bases
Orientation:
Plus strand

Genomic View for CHMP7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP7 Gene

Proteins for CHMP7 Gene

  • Protein details for CHMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUX9-CHMP7_HUMAN
    Recommended name:
    Charged multivesicular body protein 7
    Protein Accession:
    Q8WUX9
    Secondary Accessions:
    • B2RDT3
    • B4DKJ6
    • D3DSS1
    • Q8NDM1
    • Q9BT50

    Protein attributes for CHMP7 Gene

    Size:
    453 amino acids
    Molecular mass:
    50911 Da
    Quaternary structure:
    • Interacts with CHMP4B, but not with VPS25.

    Alternative splice isoforms for CHMP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHMP7 Gene

Proteomics data for CHMP7 Gene at MOPED

Post-translational modifications for CHMP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHMP7 Gene

Antibody Products

No data available for DME Specific Peptides for CHMP7 Gene

Domains for CHMP7 Gene

Gene Families for CHMP7 Gene

HGNC:
  • CHMP :Charged multivesicular body proteins

Protein Domains for CHMP7 Gene

Suggested Antigen Peptide Sequences for CHMP7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUX9

UniProtKB/Swiss-Prot:

CHMP7_HUMAN :
  • Q8WUX9
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP7: view

Function for CHMP7 Gene

Molecular function for CHMP7 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the endosomal sorting pathway.

Gene Ontology (GO) - Molecular Function for CHMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IMP 16856878
genes like me logo Genes that share ontologies with CHMP7: view

Phenotypes for CHMP7 Gene

genes like me logo Genes that share phenotypes with CHMP7: view

Animal Model Products

miRNA for CHMP7 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHMP7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHMP7 Gene

Localization for CHMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP7 Gene

Cytoplasm. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHMP7 Gene COMPARTMENTS Subcellular localization image for CHMP7 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 4

Gene Ontology (GO) - Cellular Components for CHMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000815 ESCRT III complex IDA 16856878
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHMP7: view

Pathways for CHMP7 Gene

genes like me logo Genes that share pathways with CHMP7: view

Pathways by source for CHMP7 Gene

1 KEGG pathway for CHMP7 Gene

Gene Ontology (GO) - Biological Process for CHMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport --
GO:0007080 mitotic metaphase plate congression IMP 20616062
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with CHMP7: view

Transcripts for CHMP7 Gene

Unigene Clusters for CHMP7 Gene

Charged multivesicular body protein 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHMP7

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - -
SP8:
SP9: -

Relevant External Links for CHMP7 Gene

GeneLoc Exon Structure for
CHMP7
ECgene alternative splicing isoforms for
CHMP7

Expression for CHMP7 Gene

mRNA expression in normal human tissues for CHMP7 Gene

Protein differential expression in normal tissues for CHMP7 Gene

This gene is overexpressed in Lymph node (17.9), Peripheral blood mononuclear cells (17.4), and Blymphocyte (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHMP7 Gene

SOURCE GeneReport for Unigene cluster for CHMP7 Gene Hs.5019

genes like me logo Genes that share expressions with CHMP7: view

Expression partners for CHMP7 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHMP7 Gene

Orthologs for CHMP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHMP7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHMP7 35
  • 91.85 (n)
  • 96.89 (a)
CHMP7 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHMP7 35
  • 92.44 (n)
  • 94.22 (a)
CHMP7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chmp7 35
  • 90.15 (n)
  • 95.78 (a)
Chmp7 16
Chmp7 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHMP7 35
  • 99.63 (n)
  • 99.56 (a)
CHMP7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chmp7 35
  • 90.07 (n)
  • 96.67 (a)
oppossum
(Monodelphis domestica)
Mammalia CHMP7 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHMP7 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHMP7 35
  • 74.81 (n)
  • 78.31 (a)
CHMP7 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHMP7 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp7 35
  • 56.5 (n)
  • 51.99 (a)
zebrafish
(Danio rerio)
Actinopterygii chmp7 35
  • 58.7 (n)
  • 55.5 (a)
zgc73300 35
chmp7 36
  • 51 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012459 35
  • 41.62 (n)
  • 30.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5498 35
  • 39.76 (n)
  • 25.61 (a)
CG5498 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T24B8.2 35
  • 41.96 (n)
  • 28.53 (a)
T24B8.2 36
  • 25 (a)
OneToOne
Species with no ortholog for CHMP7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHMP7 Gene

ENSEMBL:
Gene Tree for CHMP7 (if available)
TreeFam:
Gene Tree for CHMP7 (if available)

Paralogs for CHMP7 Gene

Selected SIMAP similar genes for CHMP7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHMP7: view

No data available for Paralogs for CHMP7 Gene

Variants for CHMP7 Gene

Sequence variations from dbSNP and Humsavar for CHMP7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs7361 -- 23,261,692(+) GGACT(C/T)GGGGT utr-variant-3-prime
rs9828 -- 23,260,642(-) CAGCA(A/G)GCCTG utr-variant-3-prime
rs12194 -- 23,260,990(-) AAACC(A/G)CAGGG utr-variant-3-prime
rs2280934 -- 23,249,152(-) TCCAG(C/T)CTCTA intron-variant
rs2294123 -- 23,246,682(-) CAGCC(A/C)CGGCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CHMP7 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
esv2736756 CNV Deletion 23290073

Relevant External Links for CHMP7 Gene

HapMap Linkage Disequilibrium report
CHMP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP7 Gene

Disorders for CHMP7 Gene

Relevant External Links for CHMP7

Genetic Association Database (GAD)
CHMP7
Human Genome Epidemiology (HuGE) Navigator
CHMP7

No disorders were found for CHMP7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CHMP7 Gene

Publications for CHMP7 Gene

  1. CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway. (PMID: 16856878) Horii M. … Maki M. (Biochem. J. 2006) 2 3 4
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48

Products for CHMP7 Gene

Sources for CHMP7 Gene

Back to Top

Content