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Aliases for CHMP7 Gene

Aliases for CHMP7 Gene

  • Charged Multivesicular Body Protein 7 2 3 5
  • Chromatin-Modifying Protein 7 4
  • CHMP Family, Member 7 2

External Ids for CHMP7 Gene

Previous GeneCards Identifiers for CHMP7 Gene

  • GC08P023027
  • GC08P023157
  • GC08P021647
  • GC08P023101

Summaries for CHMP7 Gene

GeneCards Summary for CHMP7 Gene

CHMP7 (Charged Multivesicular Body Protein 7) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and HIV Life Cycle. GO annotations related to this gene include protein transporter activity.

UniProtKB/Swiss-Prot for CHMP7 Gene

  • ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP7 Gene

Genomics for CHMP7 Gene

Regulatory Elements for CHMP7 Gene

Enhancers for CHMP7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F023217 1.4 FANTOM5 ENCODE 29.4 -24.1 -24144 4.7 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 CHMP7 ENSG00000253200 TNFRSF10A C8orf58 SORBS3 LOC107986927 TNFRSF10C R3HCC1 ENTPD4 LOC389641
GH08F023071 1.4 Ensembl ENCODE 22.7 -169.5 -169537 4.6 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ENSG00000253200 C8orf58 ENSG00000253616 LOC107986927 CHMP7 SORBS3 ENTPD4 POLR3D TNFRSF10C TNFRSF10B
GH08F023242 1.2 ENCODE 26.3 +1.5 1536 5.5 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 CHMP7 LOC107986927 TNFRSF10A SORBS3 C8orf58 LOC100507071 LOC105379326
GH08F023301 1.4 Ensembl ENCODE 17.5 +61.2 61216 5.7 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 R3HCC1 CHMP7 ENSG00000253200 BIN3 LOC100507156 TNFRSF10A LOC389641 ENTPD4 LOC107986927 C8orf58
GH08F023174 1.5 FANTOM5 Ensembl ENCODE 12.3 -64.8 -64834 8.6 ATF1 ARID4B YY1 GTF3C2 GLIS2 FOS NFYC PPARG KAT8 RCOR2 ENSG00000253200 LOC389641 TNFRSF10A C8orf58 CHMP7 LOC107986927 ENSG00000250714 POLR3D R3HCC1 TNFRSF10C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHMP7 on UCSC Golden Path with GeneCards custom track

Promoters for CHMP7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001387789 1963 4001 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CHMP7 Gene

Chromosome:
8
Start:
23,243,637 bp from pter
End:
23,262,000 bp from pter
Size:
18,364 bases
Orientation:
Plus strand

Genomic View for CHMP7 Gene

Genes around CHMP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHMP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP7 Gene

Proteins for CHMP7 Gene

  • Protein details for CHMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUX9-CHMP7_HUMAN
    Recommended name:
    Charged multivesicular body protein 7
    Protein Accession:
    Q8WUX9
    Secondary Accessions:
    • B2RDT3
    • B4DKJ6
    • D3DSS1
    • Q8NDM1
    • Q9BT50

    Protein attributes for CHMP7 Gene

    Size:
    453 amino acids
    Molecular mass:
    50911 Da
    Quaternary structure:
    • Interacts with CHMP4B, but not with VPS25.

    Alternative splice isoforms for CHMP7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHMP7 Gene

Post-translational modifications for CHMP7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CHMP7 Gene

Domains & Families for CHMP7 Gene

Protein Domains for CHMP7 Gene

Suggested Antigen Peptide Sequences for CHMP7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUX9

UniProtKB/Swiss-Prot:

CHMP7_HUMAN :
  • Belongs to the SNF7 family.
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP7: view

Function for CHMP7 Gene

Molecular function for CHMP7 Gene

UniProtKB/Swiss-Prot Function:
ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway (PubMed:16856878).

Gene Ontology (GO) - Molecular Function for CHMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16856878
GO:0008565 protein transporter activity IMP 16856878
genes like me logo Genes that share ontologies with CHMP7: view
genes like me logo Genes that share phenotypes with CHMP7: view

Animal Model Products

miRNA for CHMP7 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHMP7 Gene

Localization for CHMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP7 Gene

Cytoplasm. Nucleus envelope. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area (PubMed:16856878). Localizes to the nucleus envelope during late anaphase (PubMed:26040712). {ECO:0000269 PubMed:16856878, ECO:0000269 PubMed:26040712}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHMP7 gene
Compartment Confidence
nucleus 5
cytosol 5
endosome 5

Gene Ontology (GO) - Cellular Components for CHMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000815 ESCRT III complex IDA 16856878
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA,IDA 26040712
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHMP7: view

Pathways & Interactions for CHMP7 Gene

genes like me logo Genes that share pathways with CHMP7: view

Pathways by source for CHMP7 Gene

Gene Ontology (GO) - Biological Process for CHMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006810 transport IEA --
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
GO:0007080 mitotic metaphase plate congression IMP 20616062
genes like me logo Genes that share ontologies with CHMP7: view

No data available for SIGNOR curated interactions for CHMP7 Gene

Transcripts for CHMP7 Gene

Unigene Clusters for CHMP7 Gene

Charged multivesicular body protein 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: - - -
SP8:
SP9: -

Relevant External Links for CHMP7 Gene

GeneLoc Exon Structure for
CHMP7
ECgene alternative splicing isoforms for
CHMP7

Expression for CHMP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHMP7 Gene

Protein differential expression in normal tissues from HIPED for CHMP7 Gene

This gene is overexpressed in Lymph node (17.9), Peripheral blood mononuclear cells (17.4), and Blymphocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHMP7 Gene



Protein tissue co-expression partners for CHMP7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHMP7 Gene:

CHMP7

SOURCE GeneReport for Unigene cluster for CHMP7 Gene:

Hs.5019
genes like me logo Genes that share expression patterns with CHMP7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHMP7 Gene

Orthologs for CHMP7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHMP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHMP7 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia CHMP7 34 35
  • 92.44 (n)
oppossum
(Monodelphis domestica)
Mammalia CHMP7 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHMP7 34 35
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Chmp7 34 16 35
  • 90.15 (n)
rat
(Rattus norvegicus)
Mammalia Chmp7 34
  • 90.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHMP7 35
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHMP7 34 35
  • 74.81 (n)
lizard
(Anolis carolinensis)
Reptilia CHMP7 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp7 34
  • 56.5 (n)
zebrafish
(Danio rerio)
Actinopterygii chmp7 34 35
  • 58.7 (n)
zgc73300 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012459 34
  • 41.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5498 34 35
  • 39.76 (n)
worm
(Caenorhabditis elegans)
Secernentea T24B8.2 34 35
  • 41.96 (n)
Species where no ortholog for CHMP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHMP7 Gene

ENSEMBL:
Gene Tree for CHMP7 (if available)
TreeFam:
Gene Tree for CHMP7 (if available)

Paralogs for CHMP7 Gene

(1) SIMAP similar genes for CHMP7 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CHMP7: view

No data available for Paralogs for CHMP7 Gene

Variants for CHMP7 Gene

Sequence variations from dbSNP and Humsavar for CHMP7 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10086496 -- 23,243,425(+) CCTAA(A/T)TGCCC upstream-variant-2KB
rs10092563 -- 23,259,314(+) caggc(A/G)cctgc intron-variant
rs10092938 -- 23,259,604(+) CCGCC(C/G)GCCTC intron-variant
rs111259946 -- 23,258,914(+) ACGAA(-/A)CCTGA intron-variant
rs11135710 -- 23,244,572(+) tgggt(A/T)gtatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHMP7 Gene

Variant ID Type Subtype PubMed ID
esv2736756 CNV deletion 23290073
esv2759604 CNV loss 17122850
nsv1017570 CNV gain 25217958
nsv1027718 CNV gain 25217958

Variation tolerance for CHMP7 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHMP7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHMP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP7 Gene

Disorders for CHMP7 Gene

Relevant External Links for CHMP7

Genetic Association Database (GAD)
CHMP7
Human Genome Epidemiology (HuGE) Navigator
CHMP7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHMP7

No disorders were found for CHMP7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHMP7 Gene

Publications for CHMP7 Gene

  1. CHMP7, a novel ESCRT-III-related protein, associates with CHMP4b and functions in the endosomal sorting pathway. (PMID: 16856878) Horii M. … Maki M. (Biochem. J. 2006) 2 3 4 64
  2. Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing. (PMID: 26040712) Vietri M. … Stenmark H. (Nature 2015) 3 4 64
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for CHMP7 Gene

Sources for CHMP7 Gene

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