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Aliases for CHMP6 Gene

Aliases for CHMP6 Gene

  • Charged Multivesicular Body Protein 6 2 3
  • Vacuolar Protein Sorting-Associated Protein 20 3 4
  • Chromatin Modifying Protein 6 2 3
  • Chromatin-Modifying Protein 6 3 4
  • HVps20 3 4
  • VPS20 3 4

External Ids for CHMP6 Gene

Previous GeneCards Identifiers for CHMP6 Gene

  • GC17P076581
  • GC17P078965
  • GC17P074403

Summaries for CHMP6 Gene

Entrez Gene Summary for CHMP6 Gene

  • This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface receptors, and in biosynthesis of endosomes. [provided by RefSeq, Mar 2012]

GeneCards Summary for CHMP6 Gene

CHMP6 (Charged Multivesicular Body Protein 6) is a Protein Coding gene. Among its related pathways are Disease and Endocytosis. GO annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot for CHMP6 Gene

  • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes

Gene Wiki entry for CHMP6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP6 Gene

Genomics for CHMP6 Gene

Regulatory Elements for CHMP6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHMP6 Gene

Start:
80,991,598 bp from pter
End:
81,009,517 bp from pter
Size:
17,920 bases
Orientation:
Plus strand

Genomic View for CHMP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHMP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP6 Gene

Proteins for CHMP6 Gene

  • Protein details for CHMP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96FZ7-CHMP6_HUMAN
    Recommended name:
    Charged multivesicular body protein 6
    Protein Accession:
    Q96FZ7
    Secondary Accessions:
    • A8K7U0
    • Q53FU4
    • Q9HAE8

    Protein attributes for CHMP6 Gene

    Size:
    201 amino acids
    Molecular mass:
    23485 Da
    Quaternary structure:
    • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with SNF8, VPS25 and VPS36.

    Three dimensional structures from OCA and Proteopedia for CHMP6 Gene

neXtProt entry for CHMP6 Gene

Proteomics data for CHMP6 Gene at MOPED

Post-translational modifications for CHMP6 Gene

  • ISGylated in a CHMP5-dependent manner. Isgylation weakens its interaction with VPS4A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHMP6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHMP6 Gene

Domains for CHMP6 Gene

Gene Families for CHMP6 Gene

HGNC:
  • CHMP :Charged multivesicular body proteins

Protein Domains for CHMP6 Gene

Suggested Antigen Peptide Sequences for CHMP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96FZ7

UniProtKB/Swiss-Prot:

CHMP6_HUMAN :
  • Q96FZ7
Domain:
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP6: view

Function for CHMP6 Gene

Molecular function for CHMP6 Gene

UniProtKB/Swiss-Prot Function:
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes

Gene Ontology (GO) - Molecular Function for CHMP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14505570
GO:0047485 protein N-terminus binding IPI 18606141
genes like me logo Genes that share ontologies with CHMP6: view

Phenotypes for CHMP6 Gene

GenomeRNAi human phenotypes for CHMP6:
genes like me logo Genes that share phenotypes with CHMP6: view

Animal Model Products

miRNA for CHMP6 Gene

miRTarBase miRNAs that target CHMP6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHMP6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHMP6 Gene

Localization for CHMP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP6 Gene

Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane. Note=Localizes to endosomal membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHMP6 Gene COMPARTMENTS Subcellular localization image for CHMP6 gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CHMP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000815 ESCRT III complex IDA 24878737
GO:0005768 endosome --
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane IDA 16973552
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CHMP6: view

Pathways for CHMP6 Gene

genes like me logo Genes that share pathways with CHMP6: view

Pathways by source for CHMP6 Gene

1 KEGG pathway for CHMP6 Gene

Gene Ontology (GO) - Biological Process for CHMP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
GO:0007080 mitotic metaphase plate congression IMP 20616062
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with CHMP6: view

Transcripts for CHMP6 Gene

Unigene Clusters for CHMP6 Gene

Charged multivesicular body protein 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHMP6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP6 Gene

No ASD Table

Relevant External Links for CHMP6 Gene

GeneLoc Exon Structure for
CHMP6
ECgene alternative splicing isoforms for
CHMP6

Expression for CHMP6 Gene

mRNA expression in normal human tissues for CHMP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for CHMP6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8), Cervix (7.0), and Bone (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHMP6 Gene

SOURCE GeneReport for Unigene cluster for CHMP6 Gene Hs.514560

mRNA Expression by UniProt/SwissProt for CHMP6 Gene

Q96FZ7-CHMP6_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with CHMP6: view

Expression partners for CHMP6 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CHMP6 Gene

Orthologs for CHMP6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHMP6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHMP6 35
  • 91.71 (n)
  • 92.54 (a)
CHMP6 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHMP6 35
  • 86.96 (n)
  • 88.7 (a)
CHMP6 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chmp6 35
  • 88 (n)
  • 93 (a)
Chmp6 16
Chmp6 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHMP6 35
  • 98.91 (n)
  • 97.83 (a)
CHMP6 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chmp6 35
  • 87.83 (n)
  • 94 (a)
oppossum
(Monodelphis domestica)
Mammalia CHMP6 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHMP6 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHMP6 35
  • 78 (n)
  • 82 (a)
CHMP6 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHMP6 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp6 35
  • 72.33 (n)
  • 74.5 (a)
Str.17227 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.23929 35
zebrafish
(Danio rerio)
Actinopterygii chmp6b 35
  • 68.23 (n)
  • 70.31 (a)
CHMP6 (2 of 2) 36
  • 66 (a)
OneToMany
chmp6b 36
  • 71 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006229 35
  • 61.42 (n)
  • 58.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Vps20 35
  • 62.96 (n)
  • 53.54 (a)
Vps20 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea vps-20 35
  • 53.2 (n)
  • 47.47 (a)
vps-20 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS20 36
  • 28 (a)
OneToOne
VPS20 38
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS20.2 35
  • 45.74 (n)
  • 40.96 (a)
rice
(Oryza sativa)
Liliopsida Os02g0596500 35
  • 50.09 (n)
  • 35.91 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for CHMP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHMP6 Gene

ENSEMBL:
Gene Tree for CHMP6 (if available)
TreeFam:
Gene Tree for CHMP6 (if available)

Paralogs for CHMP6 Gene

Selected SIMAP similar genes for CHMP6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHMP6: view

No data available for Paralogs for CHMP6 Gene

Variants for CHMP6 Gene

Sequence variations from dbSNP and Humsavar for CHMP6 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs13507 -- 80,999,968(-) CCTCC(A/G)GTCCT utr-variant-3-prime
rs1128687 -- 80,999,674(+) CTCTC(A/C/T)GTGCC utr-variant-3-prime
rs1128703 -- 81,000,082(+) CGGCC(A/C)CCTCG utr-variant-3-prime
rs1128705 -- 81,000,101(+) ACAGG(C/G)CGGCC utr-variant-3-prime
rs4969331 -- 80,993,115(+) CTCAG(C/T)TCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHMP6 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
dgv3304n71 CNV Loss 21882294
nsv909000 CNV Loss 21882294
nsv909003 CNV Gain 21882294
nsv909005 CNV Loss 21882294
nsv909009 CNV Gain 21882294
nsv909010 CNV Loss 21882294
nsv470618 CNV Gain 18288195
dgv3306n71 CNV Loss 21882294
dgv3307n71 CNV Loss 21882294
dgv3308n71 CNV Loss 21882294
dgv3309n71 CNV Loss 21882294
nsv909018 CNV Loss 21882294
esv1004379 CNV Deletion 20482838
esv1442457 CNV Deletion 17803354

Relevant External Links for CHMP6 Gene

HapMap Linkage Disequilibrium report
CHMP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP6 Gene

Disorders for CHMP6 Gene

No disorders were found for CHMP6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CHMP6 Gene

Publications for CHMP6 Gene

  1. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. (PMID: 15511219) Yorikawa C. … Maki M. (Biochem. J. 2005) 2 3 4 23
  2. Structure and function of human Vps20 and Snf7 proteins. (PMID: 14583093) Peck J.W. … Burbelo P.D. (Biochem. J. 2004) 3 4 23
  3. Overexpression of CHMP6 induces cellular oncosis and apoptosis in HeLa cells. (PMID: 19270365) Fu D. … Wang Y. (Biosci. Biotechnol. Biochem. 2009) 3 23
  4. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PMID: 11559748) Howard T.L. … Hollenberg S.M. (J. Cell Sci. 2001) 2 3
  5. The protein network of HIV budding. (PMID: 14505570) von Schwedler U.K. … Sundquist W.I. (Cell 2003) 3 4

Products for CHMP6 Gene

Sources for CHMP6 Gene

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