Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CHMP6 Gene

protein-coding   GIFtS: 59
GCID: GC17P078965

Charged Multivesicular Body Protein 6

(Previous name: chromatin modifying protein 6)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Charged Multivesicular Body Protein 61 2     VPS202 3
Chromatin Modifying Protein 61 2     hVps202 3
Chromatin-Modifying Protein 62 3     Vps203
Vacuolar Protein Sorting-Associated Protein 202 3     

External Ids:    HGNC: 256751   Entrez Gene: 796432   Ensembl: ENSG000001761087   OMIM: 6109015   UniProtKB: Q96FZ73   

Export aliases for CHMP6 gene to outside databases

Previous GC identifers: GC17P076581 GC17P074403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CHMP6 Gene:
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins
in this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades
surface receptors, and in biosynthesis of endosomes. (provided by RefSeq, Mar 2012)

GeneCards Summary for CHMP6 Gene:
CHMP6 (charged multivesicular body protein 6) is a protein-coding gene. Diseases associated with CHMP6 include conjunctivitis, and hiv-1. GO annotations related to this gene include protein N-terminus binding.

UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs
contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane
of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as
stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the
sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the
invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent
membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1
and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or
membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it
probably serves as an acceptor for the ESCRT-II complex on endosomal membranes

Gene Wiki entry for CHMP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHMP6 gene promoter:
         AP-2rep   p53   Lmo2   MyoD   MIF-1   AP-4   Gfi-1   YY1   GATA-2   HEN1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHMP6 promoter sequence
   Search Chromatin IP Primers for CHMP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHMP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

CHMP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P078965:  view genomic region     (about GC identifiers)

Start:
78,965,398 bp from pter      End:
78,983,317 bp from pter
Size:
17,920 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7 (See protein sequence)
Recommended Name: Charged multivesicular body protein 6  
Size: 201 amino acids; 23485 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III).
ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome.
Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VPS4A; the
interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C.
Interacts with SNF8, VPS25 and VPS36
2 PDB 3D structures from and Proteopedia for CHMP6:
2K3W (3D)        3HTU (3D)    
Secondary accessions: A8K7U0 Q53FU4 Q9HAE8

Explore the universe of human proteins at neXtProt for CHMP6: NX_Q96FZ7

Explore proteomics data for CHMP6 at MOPED

Post-translational modifications: 

  • ISGylated in a CHMP5-dependent manner. Isgylation weakens its interaction with VPS4A1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CHMP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078867.2  
    ENSEMBL proteins: 
     ENSP00000460389   ENSP00000317468   ENSP00000461098   ENSP00000461238  
    Reactome Protein details: Q96FZ7

    CHMP6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CHMP6
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CHMP6
    GenScript Custom Purified and Recombinant Proteins Services for CHMP6
    Novus Biologicals CHMP6 Proteins
    Novus Biologicals CHMP6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CHMP6
    Cloud-Clone Corp. Proteins for CHMP6

    CHMP6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHMP6
    Novus Biologicals CHMP6 Antibodies
    Abcam antibodies for CHMP6
    Cloud-Clone Corp. Antibodies for CHMP6
    ThermoFisher Antibodies for CHMP6
    LSBio Antibodies in human, mouse, rat for CHMP6

    CHMP6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHMP6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHMP6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHMP6
    Cloud-Clone Corp. CLIAs for CHMP6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CHMP: Charged multivesicular body proteins

    1 InterPro protein domain:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry Q96FZ7

    ProtoNet protein and cluster: Q96FZ7

    1 Blocks protein domain: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7
    Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and
    inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation,
    which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding
    partners, probably including other ESCRT components
    Similarity: Belongs to the SNF7 family


    CHMP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHMP6_HUMAN, Q96FZ7
    Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
    involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs
    contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane
    of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as
    stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the
    sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the
    invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent
    membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1
    and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or
    membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it
    probably serves as an acceptor for the ESCRT-II complex on endosomal membranes

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0047485protein N-terminus binding IPI18606141
         
    CHMP6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHMP6:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHMP6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHMP6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHMP6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHMP6

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHMP6:
    hsa-mir-26b-5p (MIRT028818)

    Block miRNA regulation of human, mouse, rat CHMP6 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CHMP6:
    hsa-miR-214 hsa-miR-1226 hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-761 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCHMP6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHMP6
    Predesigned siRNA for gene silencing in human, mouse, rat CHMP6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHMP6

    Clone
    Products:
         
    OriGene clones in human, mouse for CHMP6 (see all 6)
    OriGene ORF clones in mouse, rat for CHMP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHMP6 (NM_024591)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHMP6
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHMP6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CHMP6_HUMAN, Q96FZ7: Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane (Probable).
    Note=Localizes to endosomal membranes
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol4
    nucleus2
    mitochondrion1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0012505endomembrane system ----
    GO:0031902late endosome membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    CHMP6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CHMP6 About    
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for CHMP6
        Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for CHMP6):
        Endocytosis


    CHMP6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHMP6
    Interactions:

        GeneGlobe Interaction Network for CHMP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHMP6 (Q96FZ72, 3 ENSP000003174684) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP54Q70EL12, 3, ENSP000003452164MINT-6947377 I2D: score=1 STRING: ENSP00000345216
    USP8P408182, 3, ENSP000003022394MINT-6946916 I2D: score=1 STRING: ENSP00000302239
    CHMP4BQ9H4443, ENSP000002174024I2D: score=6 STRING: ENSP00000217402
    VPS25Q9BRG13, ENSP000002537944I2D: score=5 STRING: ENSP00000253794
    CHMP4AQ9BY433, ENSP000003242054I2D: score=2 STRING: ENSP00000324205
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016032viral process TAS--
    GO:0016197endosomal transport TAS--
    GO:0019058viral life cycle TAS--
    GO:0061024membrane organization TAS--

    CHMP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHMP6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CHMP6 gene: 
    NM_024591.4  

    Unigene Cluster for CHMP6:

    Charged multivesicular body protein 6
    Hs.514560  [show with all ESTs]
    Unigene Representative Sequence: NM_024591
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572525 ENST00000325167(uc002jyw.4) ENST00000572778 ENST00000571457

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHMP6 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate CHMP6:
    hsa-miR-214 hsa-miR-1226 hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-761 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCHMP6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHMP6
    Predesigned siRNA for gene silencing in human, mouse, rat CHMP6
    Clone
    Products:
         
    OriGene clones in human, mouse for CHMP6 (see all 6)
    OriGene ORF clones in mouse, rat for CHMP6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHMP6 (NM_024591)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHMP6
    OriGene qSTAR qPCR primer pairs in human, mouse for CHMP6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHMP6
      QuantiTect SYBR Green Assays in human, mouse, rat CHMP6
      QuantiFast Probe-based Assays in human, mouse, rat CHMP6

    Additional mRNA sequence: 

    AK021811.1 AK223187.1 AK292105.1 AY329087.1 BC010108.2 CR457284.1 

    8 DOTS entries:

    DT.412290  DT.100670179  DT.100794028  DT.438071  DT.92429255  DT.95338794  DT.95338814  DT.97776361 

    Selected AceView cDNA sequences (see all 195):

    BM720019 BM983062 AI686019 BM786576 BM807877 BU167285 CB131166 BM711696 
    BU554096 BG030574 BM976788 BI489967 BM913051 BQ017176 CD674909 CA393241 
    BI963039 BU175054 BU730295 CK903631 BE389556 BM727392 BM354096 BQ681004 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CHMP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTGACTTC
    CHMP6 Expression
    About this image


    CHMP6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CHMP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHMP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514560

    UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7
    Tissue specificity: Ubiquitously expressed

        Custom PCR Arrays for CHMP6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHMP6
    OriGene qSTAR qPCR primer pairs in human, mouse for CHMP6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHMP6
    QuantiTect SYBR Green Assays in human, mouse, rat CHMP6
    QuantiFast Probe-based Assays in human, mouse, rat CHMP6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHMP6 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chmp61 , 5 charged multivesicular body protein 61, 5 88(n)1
    93(a)1
      11 (83.96 cM)5
    2080921  NM_001085498.21  NP_001078967.11 
     1199134415 
    chicken
    (Gallus gallus)
    Aves CHMP61 charged multivesicular body protein 6 78(n)
    82(a)
      428673  NM_001031529.1  NP_001026700.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHMP66
    charged multivesicular body protein 6
    85(a)
    1 ↔ 1
    2(99702892-99712077)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239292 Xenopus laevis transcribed sequence with moderate similarity more 74.47(n)    BJ626402.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chmp6b1 chromatin modifying protein 6b 68.23(n)
    70.31(a)
      445397  NM_001003874.1  NP_001003874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps201 Vacuolar protein sorting 20 62.96(n)
    53.54(a)
      37581  NM_166536.2  NP_726213.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-201 vps-20 53.2(n)
    47.47(a)
      171654  NM_058361.6  NP_490762.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS20(YMR077C)4 Myristoylated subunit of ESCRTIII, the endosomal sorting more   --   13(422149-421484) 855101  NP_013794.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS20.21 VPS20.2 45.74(n)
    40.96(a)
      830785  NM_120962.2  NP_196488.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05965001 Os02g0596500 50.09(n)
    35.91(a)
      4329866  NM_001053857.1  NP_001047322.1 


    ENSEMBL Gene Tree for CHMP6 (if available)
    TreeFam Gene Tree for CHMP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CHMP6 gene
    2 SIMAP similar genes for CHMP6 using alignment to 4 protein entries:     CHMP6_HUMAN (see all proteins):
    TM9SF1    CHMP4A

    CHMP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CHMP6 (see all 317)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163201031,2
    C,F--78963711(+) AGCCAC/TGGGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1418589201,2
    --78963738(+) CCTGTA/GCCTGT 1 -- us2k10--------
    rs1501978801,2
    --78963785(+) CTCAAC/GCGTCT 1 -- us2k10--------
    rs1883858671,2
    --78963850(+) TTTCTC/TTTTTT 1 -- us2k10--------
    rs1387804421,2
    --78963913(+) AGCTCA/CCTGCA 1 -- us2k10--------
    rs780573211,2
    C,F--78963975(+) CTGCGG/ATTACA 1 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1928356291,2
    --78964032(+) ACGGTC/GCACTA 1 -- us2k10--------
    rs1473942611,2
    --78964077(+) AGGTGA/TTCCAC 1 -- us2k10--------
    rs80715141,2
    C,F,A--78964083(+) tccacC/Acacct 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1437286281,2
    C--78964089(+) CACCTC/TAGCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHMP6 (78965398 - 78983317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CHMP6 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1442457CNV Deletion17803354
    esv1004379CNV Deletion20482838
    nsv909010CNV Loss21882294
    dgv3309n71CNV Loss21882294
    dgv3308n71CNV Loss21882294
    dgv3306n71CNV Loss21882294
    dgv3304n71CNV Loss21882294
    nsv909000CNV Loss21882294
    nsv909005CNV Loss21882294
    nsv828128CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHMP6
    DNA2.0 Custom Variant and Variant Library Synthesis for CHMP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610901    OMIM disorders: --

    4 diseases for CHMP6:    
    About MalaCards
    conjunctivitis    hiv-1    sarcoma    malaria


    CHMP6 for disorders           About GeneDecksing


    Export disorders for CHMP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CHMP6 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with CHMP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. (PubMed id 15511219)1, 2, 3, 9 Yorikawa C.... Maki M. (Biochem. J. 2005)
    2. Structure and function of human Vps20 and Snf7 proteins. (PubMed id 14583093)1, 2, 9 Peck J.W.... Burbelo P.D. (Biochem. J. 2004)
    3. Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. (PubMed id 18606141)1, 2 Kieffer C.... Sundquist W.I. (Dev. Cell 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (Cell 2003)
    7. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. (PubMed id 14519844)1, 2 Martin-Serrano J.... Bieniasz P.D. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PubMed id 11559748)1, 3 Howard T.L.... Hollenberg S.M. (J. Cell Sci. 2001)
    9. Overexpression of CHMP6 induces cellular oncosis and apoptosis in HeLa cells. (PubMed id 19270365)1, 9 Fu D....Wang Y. (Biosci. Biotechnol. Biochem. 2009)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79643 HGNC: 25675 AceView: FLJ11749 Ensembl:ENSG00000176108 euGenes: HUgn79643
    ECgene: CHMP6 Kegg: 79643 H-InvDB: CHMP6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CHMP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CHMP6 gene:
    Search GeneIP for patents involving CHMP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHMP6  
     OriGene qPCR primer pairs and template standards for CHMP6   OriGene Protein Over-expression Lysate for CHMP6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CHMP6  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHMP6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CHMP6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHMP6   OriGene Custom Protein Services for CHMP6  

     
     
     Block miRNA regulation of human, mouse, rat CHMP6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CHMP6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHMP6 Predesigned siRNA for gene silencing in human, mouse, rat CHMP6
     QuantiFast Probe-based Assays in human, mouse, rat CHMP6 QuantiTect SYBR Green Assays in human, mouse, rat CHMP6
     Custom PCR Arrays for CHMP6 Search Chromatin IP Primers for CHMP6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHMP6  GeneGlobe Interaction Network for CHMP6
     Regulatory tfbs in CHMP6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CHMP6 GenScript cDNA clones with any tag delivered in your preferred vector for CHMP6
     GenScript Custom Assay Services for CHMP6 GenScript Custom overexpressing Cell Line Services for CHMP6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CHMP6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CHMP6 antibodies
     CHMP6 proteins
     CHMP6 lysates
     Antibodies for CHMP6
     See all of Abcam's Antibodies, Kits and Proteins for CHMP6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CHMP6
     Proteins for CHMP6
     Antibodies for CHMP6
     ELISAs for CHMP6
     CLIAs for CHMP6



     Browse ESI BIO Cell Lines and PureStem Progenitors for CHMP6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP6
     SwitchGear 3'UTR luciferase reporter plasmids for CHMP6
     SwitchGear Promoter luciferase reporter plasmids for CHMP6
     ThermoFisher Antibodies for CHMP6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHMP6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHMP6
     LSBio Antibodies in human, mouse, rat for CHMP6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHMP6 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4