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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHMP6 Gene

protein-coding   GIFtS: 55
GCID: GC17P078965

charged multivesicular body protein 6

(Previous name: chromatin modifying protein 6 )
 Explore 2 diseases affiliated with
CHMP6 via our new
 Human Malady Compendium 
Biological research products
for CHMP6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Charged Multivesicular Body Protein 61 2     Vacuolar Protein Sorting-Associated Protein 202 3
VPS201 2 3     HVps201
Chromatin Modifying Protein 61 2     FLJ117491
Chromatin-Modifying Protein 62 3     Vps203

External Ids:    HGNC: 256751   Entrez Gene: 796432   Ensembl: ENSG000001761087   OMIM: 6109015   UniProtKB: Q96FZ73   

Export aliases for CHMP6 gene to outside databases

Previous GC identifers: GC17P076581 GC17P074403


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHMP6:
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein family. Proteins in
this family are part of the ESCRT-III (endosomal sorting complex required for transport III) which degrades surface
receptors, and in biosynthesis of endosomes. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the
endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth
factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,
-I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is
released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal
stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are
believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with
the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal
membranes

Gene Wiki entry for CHMP6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHMP6 gene promoter:
         AP-2rep   p53   Lmo2   MyoD   MIF-1   AP-4   Gfi-1   YY1   GATA-2   HEN1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHMP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHMP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

CHMP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP6 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P078965:  view genomic region     (about GC identifiers)

Start:
78,965,398 bp from pter      End:
78,983,317 bp from pter
Size:
17,920 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7 (See protein sequence)
Recommended Name: Charged multivesicular body protein 6  
Size: 201 amino acids; 23485 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III
components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several
assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VPS4A; the interaction is
direct. Interacts with VPS4B; the interaction is direct. Interacts with CHMP4A, CHMP4B and CHMP4C. Interacts with
SNF8, VPS25 and VPS36
Subcellular location: Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane (Probable).
Note=Localizes to endosomal membranes
2 PDB 3D structures from and Proteopedia for CHMP6:
2K3W (3D)        3HTU (3D)    
Secondary accessions: A8K7U0 Q53FU4 Q9HAE8

Explore the universe of human proteins at neXtProt for CHMP6: NX_Q96FZ7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96FZ7

  • CHMP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_078867.2  
    ENSEMBL proteins: 
     ENSP00000460389   ENSP00000317468   ENSP00000461098   ENSP00000461238  
    Reactome Protein details: Q96FZ7
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    ProSpec Recombinant Protein for CHMP6
    Uscn Proteins for CHMP6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0012505endomembrane system IEA--
    GO:0031902late endosome membrane IEA--


    CHMP6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CHMP6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry Q96FZ7

    ProtoNet protein and cluster: Q96FZ7

    1 Blocks protein family: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7
    Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and
    inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which
    enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners,
    probably including other ESCRT components
    Similarity: Belongs to the SNF7 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7
    Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
    involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the
    endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth
    factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,
    -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is
    released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal
    stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are
    believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with
    the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal
    membranes

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    hsa-miR-214 hsa-miR-1226 hsa-miR-3065-3p hsa-miR-29c hsa-miR-29a hsa-miR-761 hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidCHMP6 3' UTR sequence
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0047485protein N-terminus binding IPI18606141


    CHMP6 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CHMP6:
     Decreased nuclei size in G2M 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Membrane Trafficking
    Membrane Trafficking1.00
    2Endocytosis
    Endocytosis1.00
    3Signal Transduction
    Endosomal Sorting Complex Required For Transport (ESCRT)0.14

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for CHMP6
        Membrane Trafficking
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1         Kegg Pathway  (Kegg details for CHMP6):
        Endocytosis


    CHMP6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHMP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/41 Interacting proteins for CHMP6 (Q96FZ72, 3 ENSP000003174684) via UniProtKB, MINT, STRING, and/or I2D (see all 41)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP54Q70EL12, 3, ENSP000003452164MINT-6947377 I2D: score=1 STRING: ENSP00000345216
    USP8P408182, 3, ENSP000003022394MINT-6946916 I2D: score=1 STRING: ENSP00000302239
    CHMP4BQ9H4443, ENSP000002174024I2D: score=6 STRING: ENSP00000217402
    VPS25Q9BRG13, ENSP000002537944I2D: score=5 STRING: ENSP00000253794
    CHMP4AQ9BY433, ENSP000003242054I2D: score=2 STRING: ENSP00000324205
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016044cellular membrane organization TAS--
    GO:0016197endosomal transport TAS--


    CHMP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHMP6
    Search CenterWatch for drugs/clinical trials and news about CHMP6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHMP6 gene: 
    NM_024591.4  

    Unigene Cluster for CHMP6:

    Charged multivesicular body protein 6
    Hs.514560  [show with all ESTs]
    Unigene Representative Sequence: NM_024591
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000572525 ENST00000325167(uc002jyw.4) ENST00000572778 ENST00000571457


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    Additional cDNA sequence: 

    AK021811.1 AK223187.1 AK292105.1 AY329087.1 BC010108.2 CR457284.1 

    8 DOTS entries:

    DT.412290  DT.100670179  DT.100794028  DT.438071  DT.92429255  DT.95338794  DT.95338814  DT.97776361 

    24/195 AceView cDNA sequences (see all 195):

    CD674909 BU730295 BM921813 CA393241 AI686019 CB131166 CA454559 BU554096 
    BE783904 BG030574 BU167285 CD512753 BM786576 BQ673540 BM976788 AY329087 
    BM807877 BM908143 CD516369 CK903631 BM354096 BP376553 BU175054 BI963039 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHMP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCGTGACTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CHMP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHMP6

    SOURCE GeneReport for Unigene cluster: Hs.514560

    UniProtKB/Swiss-Prot: CHMP6_HUMAN, Q96FZ7
    Tissue specificity: Ubiquitously expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHMP6 gene from 9/31 species (see all 31)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves CHMP61 chromatin modifying protein 6 78(n)
    82(a)
      428673  NM_001031529.1  NP_001026700.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHMP66
    --
    84(a)
    1 ↔ 1
    2(99702892-99711590)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.239292 Xenopus laevis transcribed sequence with moderate similarity more 74.47(n)    BJ626402.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chmp6b1 chromatin modifying protein 6b 67.71(n)
    70.31(a)
      445397  NM_001003874.1  NP_001003874.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Vps201 Vacuolar protein sorting 20 62.96(n)
    53.54(a)
      37581  NM_137842.3  NP_611686.2 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-201 Protein VPS-20 53.3(n)
    47.72(a)
      171654  NM_058361.5  NP_490762.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS20(YMR077C)4
    VPS201
    Myristoylated subunit of ESCRTIII, the endosomal sorting more4
    Vps20p1
    45.81(n)1
    31.02(a)1
      13(422149-421484)4
    8551011, 4  NP_013794.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS20.11 vacuolar protein sorting-associated protein 20-1 46.31(n)
    38.38(a)
      836508  NM_001203681.1  NP_001190610.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g05965001 hypothetical protein 49.91(n)
    35.91(a)
      4329866  NM_001053857.1  NP_001047322.1 


    ENSEMBL Gene Tree for CHMP6 (if available)
    TreeFam Gene Tree for CHMP6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHMP6 gene
    CHMP72  
    2 SIMAP similar genes for CHMP6 using alignment to 4 protein entries:     CHMP6_HUMAN (see all proteins):
    TM9SF1    CHMP4A

    CHMP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 NCBI SNPs in CHMP6 are shown (see all 245    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163201031,2
    C,F,--78963711(+) AGCCAC/TGGGAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1418589201,2
    --78963738(+) CCTGTA/GCCTGT 1 -- us2k10--------
    rs1501978801,2
    --78963785(+) CTCAAC/GCGTCT 1 -- us2k10--------
    rs1883858671,2
    --78963850(+) TTTCTC/TTTTTT 1 -- us2k10--------
    rs1387804421,2
    --78963913(+) AGCTCA/CCTGCA 1 -- us2k10--------
    rs780573211,2
    C,F,--78963975(+) CTGCGG/ATTACA 1 -- us2k12Minor allele frequency- A:0.50WA CSA 4
    rs1928356291,2
    --78964032(+) ACGGTC/GCACTA 1 -- us2k10--------
    rs1473942611,2
    --78964077(+) AGGTGA/TTCCAC 1 -- us2k10--------
    rs80715141,2
    C,F,A,--78964083(+) TCCACC/ACACCT 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs1437286281,2
    --78964089(+) CACCTC/TAGCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHMP6 (78965398 - 78983317 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CHMP6
         1 CNV: 73071

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CHMP6 for disorders           About GeneDecksing

    OMIM gene information: 610901    OMIM disorders: --

    2 diseases for CHMP6:    About MalaCards
    conjunctivitis    immunodeficiency


    Export disorders for CHMP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHMP6 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CHMP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. (PubMed id 15511219)1, 2, 3, 9 Yorikawa C....Maki M. (2005)
    2. Structure and function of human Vps20 and Snf7 proteins. (PubMed id 14583093)1, 2, 9 Peck J.W.... Burbelo P.D. (2004)
    3. Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. (PubMed id 18606141)1, 2 Kieffer C....Sundquist W.I. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)
    7. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. (PubMed id 14519844)1, 2 Martin-Serrano J.... Bieniasz P.D. (2003)
    8. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PubMed id 11559748)1, 3 Howard T.L....Hollenberg S.M. (2001)
    9. Overexpression of CHMP6 induces cellular oncosis and apoptosis in HeLa cells. (PubMed id 19270365)1, 9 Fu D....Wang Y. (2009)
    10. CHMP6 and VPS4A mediate the recycling of Ras to the pl asma membrane to promote growth factor signaling. (PubMed id 22231449)1 Zheng Z.Y....Chang E.C. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79643 HGNC: 25675 AceView: FLJ11749 Ensembl:ENSG00000176108 euGenes: HUgn79643
    ECgene: CHMP6 Kegg: 79643 H-InvDB: CHMP6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHMP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHMP6 gene:
    Search GeneIP for patents involving CHMP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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