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Aliases for CHMP5 Gene

Aliases for CHMP5 Gene

  • Charged Multivesicular Body Protein 5 2 3 5
  • Vacuolar Protein Sorting-Associated Protein 60 3 4
  • SNF7 Domain-Containing Protein 2 3 4
  • Chromatin-Modifying Protein 5 3 4
  • C9orf83 3 4
  • SNF7DC2 3 4
  • HVps60 3 4
  • Vps60 3 4
  • Chromosome 9 Open Reading Frame 83 2
  • Apoptosis-Related Protein PNAS-2 3
  • Chromatin Modifying Protein 5 2
  • SNF7 Domain Containing 2 3
  • HSPC177 3
  • CGI-34 3
  • PNAS-2 3

External Ids for CHMP5 Gene

Previous HGNC Symbols for CHMP5 Gene

  • C9orf83
  • SNF7DC2

Summaries for CHMP5 Gene

Entrez Gene Summary for CHMP5 Gene

  • CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHMP5 Gene

CHMP5 (Charged Multivesicular Body Protein 5) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and HIV Life Cycle.

UniProtKB/Swiss-Prot for CHMP5 Gene

  • Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Wiki entry for CHMP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP5 Gene

Genomics for CHMP5 Gene

Regulatory Elements for CHMP5 Gene

Enhancers for CHMP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F033286 1.4 Ensembl ENCODE 12 +28.2 28248 13.0 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 NFX1 TCEA1P4 BAG1 SMU1 ANXA2P2 CHMP5 AQP3 B4GALT1 SPINK4 PIR32325
GH09F033239 1.3 Ensembl ENCODE 12.6 -24.7 -24707 1.3 ATF1 PKNOX1 ARNT ARID4B ZNF766 ELK1 GATA2 ZNF263 NCOA1 REST SMU1 CHMP5 BAG1 SPINK4 B4GALT1 B4GALT1-AS1 RNU4ATAC15P NFX1 TOPORS GC09P033251
GH09F033225 1.3 Ensembl ENCODE 12.5 -33.5 -33541 12.3 HDGF PKNOX1 ARID4B SIN3A BRCA1 ZNF2 ZNF121 GLIS2 FOS DEK SMU1 NFX1 BAG1 CHMP5 B4GALT1 B4GALT1-AS1 RNU4ATAC15P APTX DNAJA1 AQP3
GH09F033023 1.1 ENCODE 11.4 -239.4 -239400 4.2 PKNOX1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 APTX SMU1 DDX58 B4GALT1 DFFBP1 CHMP5 TOPORS LAGE3P1 ASS1P12 DNAJA1
GH09F033327 1.1 Ensembl ENCODE 11.3 +64.5 64453 3.4 TBP PKNOX1 SIN3A BRCA1 RAD21 RFX5 YY1 POLR3A FOS DEK NFX1 BAG1 CHMP5 LOC105376020 AQP7 PIR45697 GC09P033345 GC09M033166
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHMP5 on UCSC Golden Path with GeneCards custom track

Promoters for CHMP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001302332 -579 3001 HDGF ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ETS1 YY1

Genomic Location for CHMP5 Gene

Chromosome:
9
Start:
33,264,879 bp from pter
End:
33,282,069 bp from pter
Size:
17,191 bases
Orientation:
Plus strand

Genomic View for CHMP5 Gene

Genes around CHMP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHMP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP5 Gene

Proteins for CHMP5 Gene

  • Protein details for CHMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZZ3-CHMP5_HUMAN
    Recommended name:
    Charged multivesicular body protein 5
    Protein Accession:
    Q9NZZ3
    Secondary Accessions:
    • B2RD95
    • B4DIR6
    • Q5VXW2
    • Q96AV2
    • Q9HB68
    • Q9NYS4
    • Q9Y323

    Protein attributes for CHMP5 Gene

    Size:
    219 amino acids
    Molecular mass:
    24571 Da
    Quaternary structure:
    • Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VTA1. Interacts with CHMP2A. Interacts with VTA1; the interaction involves soluble CHMP5.
    SequenceCaution:
    • Sequence=AAG23821.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHMP5 Gene

    Alternative splice isoforms for CHMP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHMP5 Gene

Post-translational modifications for CHMP5 Gene

Other Protein References for CHMP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHMP5 Gene

Domains & Families for CHMP5 Gene

Protein Domains for CHMP5 Gene

Suggested Antigen Peptide Sequences for CHMP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZZ3

UniProtKB/Swiss-Prot:

CHMP5_HUMAN :
  • Belongs to the SNF7 family.
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP5: view

Function for CHMP5 Gene

Molecular function for CHMP5 Gene

UniProtKB/Swiss-Prot Function:
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Ontology (GO) - Molecular Function for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15644320
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with CHMP5: view
genes like me logo Genes that share phenotypes with CHMP5: view

Animal Models for CHMP5 Gene

MGI Knock Outs for CHMP5:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHMP5 Gene

Localization for CHMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP5 Gene

Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHMP5 gene
Compartment Confidence
extracellular 5
cytosol 5
nucleus 4
endosome 4
cytoskeleton 2
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IEA --
GO:0005829 cytosol TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with CHMP5: view

Pathways & Interactions for CHMP5 Gene

genes like me logo Genes that share pathways with CHMP5: view

Pathways by source for CHMP5 Gene

Gene Ontology (GO) - Biological Process for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0001919 regulation of receptor recycling IEA --
GO:0006810 transport IEA --
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
genes like me logo Genes that share ontologies with CHMP5: view

No data available for SIGNOR curated interactions for CHMP5 Gene

Transcripts for CHMP5 Gene

Unigene Clusters for CHMP5 Gene

Charged multivesicular body protein 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for CHMP5 Gene

GeneLoc Exon Structure for
CHMP5
ECgene alternative splicing isoforms for
CHMP5

Expression for CHMP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHMP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CHMP5 Gene

This gene is overexpressed in Urine (35.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHMP5 Gene



Protein tissue co-expression partners for CHMP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHMP5 Gene:

CHMP5

SOURCE GeneReport for Unigene cluster for CHMP5 Gene:

Hs.635313
genes like me logo Genes that share expression patterns with CHMP5: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHMP5 Gene

Orthologs for CHMP5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHMP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHMP5 34 35
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia CHMP5 34 35
  • 93.91 (n)
cow
(Bos Taurus)
Mammalia CHMP5 34 35
  • 93.61 (n)
oppossum
(Monodelphis domestica)
Mammalia CHMP5 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHMP5 35
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chmp5 34
  • 88.28 (n)
mouse
(Mus musculus)
Mammalia Chmp5 34 16 35
  • 87.82 (n)
chicken
(Gallus gallus)
Aves CHMP5 34 35
  • 81.74 (n)
lizard
(Anolis carolinensis)
Reptilia CHMP5 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp5 34
  • 79.3 (n)
African clawed frog
(Xenopus laevis)
Amphibia hspc177-prov 34
zebrafish
(Danio rerio)
Actinopterygii chmp5b 34 35
  • 73.97 (n)
chmp5a 35
  • 67 (a)
OneToMany
zgc64125 34
fruit fly
(Drosophila melanogaster)
Insecta CG6259 34 35
  • 62.25 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005100 34
  • 61.8 (n)
worm
(Caenorhabditis elegans)
Secernentea F41E6.9 34
  • 61.11 (n)
vps-60 35
  • 57 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03608g 34
  • 50.29 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS60 34 35 37
  • 49.76 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR116C 34
  • 47.25 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS60.2 34
  • 53.99 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9203 34
rice
(Oryza sativa)
Liliopsida Os05g0102900 34
  • 52.71 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 57 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU04541 34
  • 54.76 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC162.06c 34
  • 50.82 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5195 34
Species where no ortholog for CHMP5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHMP5 Gene

ENSEMBL:
Gene Tree for CHMP5 (if available)
TreeFam:
Gene Tree for CHMP5 (if available)

Paralogs for CHMP5 Gene

Pseudogenes.org Pseudogenes for CHMP5 Gene

genes like me logo Genes that share paralogs with CHMP5: view

No data available for Paralogs for CHMP5 Gene

Variants for CHMP5 Gene

Sequence variations from dbSNP and Humsavar for CHMP5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1056339 -- 33,282,014(+) TGCTA(A/T)GTGCA utr-variant-3-prime
rs10710870 -- 33,272,394(+) AAAGC(-/A)AAAAA intron-variant
rs1071545 -- 33,264,542(-) CCTCT(C/G)GGCGT upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs10758200 -- 33,275,782(+) AGGTG(A/G)GCAGA intron-variant
rs10971456 -- 33,276,224(+) AACCT(C/G)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHMP5 Gene

Variant ID Type Subtype PubMed ID
nsv614146 CNV gain 21841781
nsv519369 CNV gain 19592680
dgv7516n100 CNV gain 25217958

Variation tolerance for CHMP5 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHMP5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHMP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP5 Gene

Disorders for CHMP5 Gene

Relevant External Links for CHMP5

Genetic Association Database (GAD)
CHMP5
Human Genome Epidemiology (HuGE) Navigator
CHMP5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHMP5

No disorders were found for CHMP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHMP5 Gene

Publications for CHMP5 Gene

  1. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. (PMID: 15644320) Ward D.M. … Kaplan J. (J. Biol. Chem. 2005) 2 3 4 64
  2. Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. (PMID: 21543490) Kuang Z. … Leis J. (J. Virol. 2011) 3 4 64
  3. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3 46 64
  4. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. (PMID: 17261583) Ma Y.M. … Kirchhausen T. (J. Biol. Chem. 2007) 3 4 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for CHMP5 Gene

Sources for CHMP5 Gene

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