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Aliases for CHMP5 Gene

Aliases for CHMP5 Gene

  • Charged Multivesicular Body Protein 5 2 3
  • Vacuolar Protein Sorting-Associated Protein 60 3 4
  • SNF7 Domain-Containing Protein 2 3 4
  • Chromatin Modifying Protein 5 2 3
  • Chromatin-Modifying Protein 5 3 4
  • C9orf83 3 4
  • SNF7DC2 3 4
  • HVps60 3 4
  • Vps60 3 4
  • Chromosome 9 Open Reading Frame 83 2
  • Apoptosis-Related Protein PNAS-2 3
  • SNF7 Domain Containing 2 3
  • HSPC177 3
  • CGI-34 3
  • PNAS-2 3

External Ids for CHMP5 Gene

Previous HGNC Symbols for CHMP5 Gene

  • C9orf83
  • SNF7DC2

Summaries for CHMP5 Gene

Entrez Gene Summary for CHMP5 Gene

  • CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHMP5 Gene

CHMP5 (Charged Multivesicular Body Protein 5) is a Protein Coding gene. Among its related pathways are Disease and Endocytosis.

UniProtKB/Swiss-Prot for CHMP5 Gene

  • Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Wiki entry for CHMP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP5 Gene

Genomics for CHMP5 Gene

Regulatory Elements for CHMP5 Gene

Genomic Location for CHMP5 Gene

Start:
33,264,879 bp from pter
End:
33,282,069 bp from pter
Size:
17,191 bases
Orientation:
Plus strand

Genomic View for CHMP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHMP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP5 Gene

Proteins for CHMP5 Gene

  • Protein details for CHMP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZZ3-CHMP5_HUMAN
    Recommended name:
    Charged multivesicular body protein 5
    Protein Accession:
    Q9NZZ3
    Secondary Accessions:
    • B2RD95
    • B4DIR6
    • Q5VXW2
    • Q96AV2
    • Q9HB68
    • Q9NYS4
    • Q9Y323

    Protein attributes for CHMP5 Gene

    Size:
    219 amino acids
    Molecular mass:
    24571 Da
    Quaternary structure:
    • Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with VTA1. Interacts with CHMP2A. Interacts with VTA1; the interaction involves soluble CHMP5.
    SequenceCaution:
    • Sequence=AAG23821.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHMP5 Gene

    Alternative splice isoforms for CHMP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHMP5 Gene

Proteomics data for CHMP5 Gene at MOPED

Post-translational modifications for CHMP5 Gene

  • ISGylated. Isgylation inhibits its interaction with VTA1.
  • Ubiquitination at Lys44 and Lys100
  • Modification sites at PhosphoSitePlus

Other Protein References for CHMP5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHMP5 Gene

Domains for CHMP5 Gene

Gene Families for CHMP5 Gene

HGNC:
  • CHMP :Charged multivesicular body proteins

Protein Domains for CHMP5 Gene

Suggested Antigen Peptide Sequences for CHMP5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZZ3

UniProtKB/Swiss-Prot:

CHMP5_HUMAN :
  • Q9NZZ3
Family:
  • Belongs to the SNF7 family.
genes like me logo Genes that share domains with CHMP5: view

Function for CHMP5 Gene

Molecular function for CHMP5 Gene

UniProtKB/Swiss-Prot Function: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release.

Gene Ontology (GO) - Molecular Function for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15644320
genes like me logo Genes that share ontologies with CHMP5: view
genes like me logo Genes that share phenotypes with CHMP5: view

Animal Models for CHMP5 Gene

MGI Knock Outs for CHMP5:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CHMP5 Gene

Localization for CHMP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP5 Gene

Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHMP5 Gene COMPARTMENTS Subcellular localization image for CHMP5 gene
Compartment Confidence
cytosol 5
endosome 5
mitochondrion 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005768 endosome --
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with CHMP5: view

Pathways for CHMP5 Gene

genes like me logo Genes that share pathways with CHMP5: view

Pathways by source for CHMP5 Gene

1 KEGG pathway for CHMP5 Gene

Gene Ontology (GO) - Biological Process for CHMP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0001919 regulation of receptor recycling IEA --
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport --
GO:0007040 lysosome organization IEA --
genes like me logo Genes that share ontologies with CHMP5: view

Transcripts for CHMP5 Gene

Unigene Clusters for CHMP5 Gene

Charged multivesicular body protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHMP5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for CHMP5 Gene

GeneLoc Exon Structure for
CHMP5
ECgene alternative splicing isoforms for
CHMP5

Expression for CHMP5 Gene

mRNA expression in normal human tissues for CHMP5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHMP5 Gene

SOURCE GeneReport for Unigene cluster for CHMP5 Gene Hs.635313

genes like me logo Genes that share expressions with CHMP5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHMP5 Gene

Orthologs for CHMP5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHMP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHMP5 35
  • 99.54 (n)
  • 100 (a)
CHMP5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHMP5 35
  • 93.61 (n)
  • 98.63 (a)
CHMP5 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHMP5 35
  • 93.91 (n)
  • 99.54 (a)
CHMP5 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chmp5 35
  • 87.82 (n)
  • 98.63 (a)
Chmp5 16
Chmp5 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHMP5 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHMP5 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chmp5 35
  • 88.28 (n)
  • 98.63 (a)
chicken
(Gallus gallus)
Aves CHMP5 35
  • 81.74 (n)
  • 93.61 (a)
CHMP5 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHMP5 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hspc177-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia chmp5 35
  • 79.3 (n)
  • 89.95 (a)
zebrafish
(Danio rerio)
Actinopterygii chmp5a 36
  • 67 (a)
OneToMany
chmp5b 35
  • 73.97 (n)
  • 84.93 (a)
chmp5b 36
  • 79 (a)
OneToMany
zgc64125 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005100 35
  • 61.8 (n)
  • 63.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6259 35
  • 62.25 (n)
  • 63.93 (a)
CG6259 36
  • 59 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F41E6.9 35
  • 61.11 (n)
  • 61.11 (a)
vps-60 36
  • 57 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR116C 35
  • 47.25 (n)
  • 34.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS60 35
  • 49.76 (n)
  • 34.3 (a)
VPS60 36
  • 28 (a)
OneToOne
VPS60 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C03608g 35
  • 50.29 (n)
  • 33.53 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9203 35
thale cress
(Arabidopsis thaliana)
eudicotyledons VPS60.2 35
  • 53.99 (n)
  • 50.23 (a)
rice
(Oryza sativa)
Liliopsida Os05g0102900 35
  • 52.71 (n)
  • 46.98 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04541 35
  • 54.76 (n)
  • 50 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC162.06c 35
  • 50.82 (n)
  • 44.26 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5195 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 57 (a)
OneToOne
Species with no ortholog for CHMP5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHMP5 Gene

ENSEMBL:
Gene Tree for CHMP5 (if available)
TreeFam:
Gene Tree for CHMP5 (if available)

Paralogs for CHMP5 Gene

Pseudogenes.org Pseudogenes for CHMP5 Gene

genes like me logo Genes that share paralogs with CHMP5: view

No data available for Paralogs for CHMP5 Gene

Variants for CHMP5 Gene

Sequence variations from dbSNP and Humsavar for CHMP5 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs831269 -- 33,272,674(-) ggcac(A/C)cacca intron-variant
rs831270 -- 33,272,426(-) CAGGC(C/T)GTACT intron-variant
rs831271 -- 33,270,750(-) AAATA(A/C)ATGAA intron-variant
rs831272 -- 33,269,803(-) agaga(C/T)gggtt intron-variant
rs831273 -- 33,269,673(-) ATAAG(G/T)Cttta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHMP5 Gene

Variant ID Type Subtype PubMed ID
nsv519369 CNV Gain 19592680

Relevant External Links for CHMP5 Gene

HapMap Linkage Disequilibrium report
CHMP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHMP5 Gene

Disorders for CHMP5 Gene

Relevant External Links for CHMP5

Genetic Association Database (GAD)
CHMP5
Human Genome Epidemiology (HuGE) Navigator
CHMP5
genes like me logo Genes that share disorders with CHMP5: view

No data available for UniProtKB/Swiss-Prot for CHMP5 Gene

Publications for CHMP5 Gene

  1. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. (PMID: 15644320) Ward D.M. … Kaplan J. (J. Biol. Chem. 2005) 2 3 4
  2. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3 48
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PMID: 11559748) Howard T.L. … Hollenberg S.M. (J. Cell Sci. 2001) 2 3
  5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4

Products for CHMP5 Gene

Sources for CHMP5 Gene

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