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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHMP5 Gene

protein-coding   GIFtS: 59
GCID: GC09P033257

Charged Multivesicular Body Protein 5

(Previous names: chromosome 9 open reading frame 83, chromatin modifying...)
(Previous symbols: C9orf83, SNF7DC2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Charged Multivesicular Body Protein 51 2     hVps602 3
C9orf831 2 3     SNF7 Domain-Containing Protein 22 3
SNF7DC21 2 3     Chromosome 9 Open Reading Frame 831
Chromatin Modifying Protein 51 2     HSPC1772
Chromatin-Modifying Protein 52 3     PNAS-22
Vacuolar Protein Sorting-Associated Protein 602 3     Apoptosis-Related Protein PNAS-22
Vps602 3     SNF7 Domain Containing 22

External Ids:    HGNC: 269421   Entrez Gene: 515102   Ensembl: ENSG000000860657   OMIM: 6109005   UniProtKB: Q9NZZ33   

Export aliases for CHMP5 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHMP5 Gene:
CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins
are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in
degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have
both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for
both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).(supplied by
OMIM, Mar 2008)

GeneCards Summary for CHMP5 Gene: 
CHMP5 (charged multivesicular body protein 5) is a protein-coding gene. Diseases associated with CHMP5 include conjunctivitis, and prostate cancer, and among its related super-pathways are HIV Life Cycle and Budding and maturation of HIV virion. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: CHMP5_HUMAN, Q9NZZ3
Function: Probable peripherally associated component of the endosomal sorting required for transport complex III
(ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins
into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the
limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane
proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to
require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from
the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically
equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped
viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle
extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1
p6- and p9-dependent virus release

Gene Wiki entry for CHMP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHMP5 gene promoter:
         ER-alpha   GR   LHX3b/Lhx3b   RFX1   Evi-1   POU2F1   POU2F1a   LHX3a/Lhx3a   GR-alpha   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHMP5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHMP5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p13.3

CHMP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP5 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033257:  view genomic region     (about GC identifiers)

Start:
33,264,877 bp from pter      End:
33,282,067 bp from pter
Size:
17,191 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHMP5_HUMAN, Q9NZZ3 (See protein sequence)
Recommended Name: Charged multivesicular body protein 5  
Size: 219 amino acids; 24571 Da
Subunit: Probable peripherally associated component of the endosomal sorting required for transport complex III
(ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of
the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with
VTA1. Interacts with CHMP2A. Interacts with VTA1; the interaction involves soluble CHMP5
Subcellular location: Cytoplasm, cytosol. Endosome membrane; Peripheral membrane protein (Probable).
Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming
body
Sequence caution: Sequence=AAG23821.1; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for CHMP5:
2LXM (3D)        3ULY (3D)        3UM0 (3D)        3UM1 (3D)        3UM2 (3D)    
Secondary accessions: B2RD95 B4DIR6 Q5VXW2 Q96AV2 Q9HB68 Q9NYS4 Q9Y323
Alternative splicing: 2 isoforms:  Q9NZZ3-1   Q9NZZ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHMP5: NX_Q9NZZ3

Explore proteomics data for CHMP5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NZZ3

  • CHMP5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHMP5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001182465.1  NP_057494.3  

    ENSEMBL proteins: 
     ENSP00000223500   ENSP00000442725  
    Reactome Protein details: Q9NZZ3
    Human Recombinant Protein Products for CHMP5: 
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    OriGene Protein Over-expression Lysate for CHMP5
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    Novus Biologicals CHMP5 Proteins
    Novus Biologicals CHMP5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CHMP5
    Cloud-Clone Corp. Proteins for CHMP5 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0010008endosome membrane IEA--

    CHMP5 for ontologies           About GeneDecksing



    CHMP5 Antibody Products: 
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    ThermoFisher Antibody for CHMP5
    LSBio Antibodies in human, mouse, rat for CHMP5 

    Assay Products for CHMP5: 
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    Cloud-Clone Corp. ELISAs for CHMP5 
    Cloud-Clone Corp. CLIAs for CHMP5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHMP: Charged multivesicular body proteins

    1 InterPro protein domain:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry Q9NZZ3

    ProtoNet protein and cluster: Q9NZZ3

    1 Blocks protein domain: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHMP5_HUMAN, Q9NZZ3
    Similarity: Belongs to the SNF7 family


    CHMP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHMP5_HUMAN, Q9NZZ3
    Function: Probable peripherally associated component of the endosomal sorting required for transport complex III
    (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins
    into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the
    limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane
    proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to
    require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from
    the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically
    equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped
    viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle
    extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in HIV-1
    p6- and p9-dependent virus release

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17711858
         
    CHMP5 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chmp5):
     cardiovascular system  cellular  embryogenesis  growth/size  mortality/aging 
     nervous system 

    CHMP5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chmp5tm1Gho for CHMP5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHMP5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHMP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHMP5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHMP5 

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CHMP5 (see all 22):
    hsa-miR-323-3p hsa-miR-676 hsa-miR-607 hsa-miR-429 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-496 hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHMP5 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CHMP5 (NM_016410)
    Sino Biological Human cDNA Clone for CHMP5
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                         Customized lentivirus expression plasmids for stable overexpression of CHMP5 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHMP5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    2Endosomal Sorting Complex Required For Transport (ESCRT)
    Endosomal Sorting Complex Required For Transport (ESCRT)0.71
    Budding and maturation of HIV virion0.71
    3Membrane Trafficking
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/7        Reactome Pathways for CHMP5 (see all 7)
        HIV Life Cycle
    HIV Infection
    Late Phase of HIV Life Cycle
    Membrane Trafficking
    Budding and maturation of HIV virion


    1         Kegg Pathway  (Kegg details for CHMP5):
        Endocytosis


    CHMP5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHMP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/64 Interacting proteins for CHMP5 (Q9NZZ31, 2, 3 ENSP000002235004) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APPBP2Q926242, 3, ENSP000000831824MINT-68074 I2D: score=5 STRING: ENSP00000083182
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001919regulation of receptor recycling IEA--
    GO:0007040lysosome organization IEA--
    GO:0008333endosome to lysosome transport IEA--
    GO:0015031protein transport IEA--
    GO:0016032viral process TAS--

    CHMP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHMP5

    Search CenterWatch for drugs/clinical trials and news about CHMP5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHMP5 gene (2 alternative transcripts): 
    NM_001195536.1  NM_016410.5  

    Unigene Cluster for CHMP5:

    Charged multivesicular body protein 5
    Hs.635313  [show with all ESTs]
    Unigene Representative Sequence: NM_016410
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000223500 ENST00000487080 ENST00000419016(uc003zsm.4 uc011lnv.2)

    miRNA
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    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate CHMP5 (see all 22):
    hsa-miR-323-3p hsa-miR-676 hsa-miR-607 hsa-miR-429 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-496 hsa-miR-3129-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHMP5 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP5
    Sirion Biotech Customized lentivirus for stable overexpression of CHMP5 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHMP5

    Additional mRNA sequence: 

    AF132968.1 AF161525.1 AF229832.1 AF275810.1 AK024753.1 AK295744.1 AK315455.1 BC006974.1 
    BC007457.1 BC016698.1 BC018603.1 BC020796.1 BC021168.1 

    24 DOTS entries:

    DT.97859589  DT.70100200  DT.100701211  DT.100878174  DT.40111737  DT.121303570  DT.100878172  DT.121156509 
    DT.92331589  DT.70104660  DT.100878175  DT.92016989  DT.92439425  DT.100878176  DT.121156531  DT.91767476 
    DT.91970777  DT.95357916  DT.95372646  DT.95372647  DT.100691501  DT.100837530  DT.40132613  DT.97839334 

    24/574 AceView cDNA sequences (see all 574):

    CR596621 BU624753 BP371154 BU616980 BU165918 CA868234 BU947635 AI358628 
    BC007457 AI612776 AF275810 BP333968 BM479659 BM090980 BX449941 AI344531 
    AW020616 CA842880 CD365582 CB243772 CB160764 BM090764 CB134059 AA421623 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CHMP5 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16
    SP1:                    -                                                                                                               
    SP2:                                                                                                                                    
    SP3:                                                                                                                                    
    SP4:                                                                                                                                    
    SP5:                                                  -                                                                                 


    ECgene alternative splicing isoforms for CHMP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHMP5 expression in normal human tissues (normalized intensities)      CHMP5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTGGGTATT
    CHMP5 Expression
    About this image


    CHMP5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             urinary bladder ; urothelial cells   
             bladder   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   

    See CHMP5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHMP5

    SOURCE GeneReport for Unigene cluster: Hs.635313
        SABiosciences Custom PCR Arrays for CHMP5
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHMP5 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chmp51 , 5 charged multivesicular body protein 51, 5 87.82(n)1
    98.63(a)1
      4 (20.69 cM)5
    769591  NM_029814.11  NP_084090.11 
     409484075 
    chicken
    (Gallus gallus)
    Aves CHMP51 chromatin modifying protein 5 81.74(n)
    93.61(a)
      420968  XM_419052.3  XP_419052.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHMP56
    charged multivesicular body protein 5
    93(a)
    1 ↔ 1
    6(56621672-56639145)
    African clawed frog
    (Xenopus laevis)
    Amphibia hspc177-prov2 hypothetical protein MGC52936 78.16(n)    BC041499.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc641252 hypothetical protein MGC64125 77.02(n)   393351  BC053265.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG62591 CG6259 62.25(n)
    63.93(a)
      39964  NM_140740.3  NP_648997.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F41E6.91 Protein F41E6.9 61.11(n)
    61.11(a)
      179242  NM_072818.3  NP_505219.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS60(YDR486C)4
    VPS601
    Cytoplasmic and vacuolar membrane protein involved more4
    Vps60p1
    49.44(n)1
    33.33(a)1
      4(1428120-1427431)4
    8520971, 4  NP_010774.41  NP_010774.24 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS60.11 charged multivesicular body protein 5 53.86(n)
    49.07(a)
      820233  NM_111900.4  NP_187675.2 
    rice
    (Oryza sativa)
    Liliopsida Os05g01029001 hypothetical protein 53.02(n)
    46.51(a)
      4337536  NM_001060924.1  NP_001054389.1 


    ENSEMBL Gene Tree for CHMP5 (if available)
    TreeFam Gene Tree for CHMP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHMP5 gene

    CHMP5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CHMP5
    PGOHUM00000244396 PGOHUM00000241268


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/270 SNPs in CHMP5 are shown (see all 270)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0520294
    ----see VAR_0520292 S P mis40--------
    rs1926286401,2
    --33266962(+) CAGATC/GCATAA 2 -- int10--------
    rs1484468371,2
    --33267455(+) TGGGCC/TATTGT 2 -- int10--------
    rs1833386871,2
    --33267527(+) GCTGTA/GCAAGT 2 -- int10--------
    rs1144979601,2
    F--33267657(+) ACAGAT/CAGGAG 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1995429351,2
    C--33267706(+) TGGGA-/GGGGAA 2 -- int10--------
    rs1427143861,2
    --33267735(+) ATTATA/GCCTAC 2 -- int10--------
    rs1510049271,2
    --33267743(+) TACTAC/TTTTGA 2 -- int10--------
    rs1398318251,2
    C--33267823(+) CCTTAA/G/TTTTTA 2 -- int10--------
    rs1876747321,2
    C--33267839(+) TCTGTT/GTTTCT 2 -- int11Minor allele frequency- G:0.00EU 1187

    HapMap Linkage Disequilibrium report for CHMP5 (33264877 - 33282067 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CHMP5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519369CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHMP5
    DNA2.0 Custom Variant and Variant Library Synthesis for CHMP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610900    OMIM disorders: --

    4 diseases for CHMP5:    About MalaCards
    conjunctivitis    prostate cancer    prostatitis    leukemia


    CHMP5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHMP5
    Human Genome Epidemiology (HuGE) Navigator: CHMP5 (1 document)

    Export disorders for CHMP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHMP5 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CHMP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells. (PubMed id 15644320)1, 2, 3 Ward D.M.... Kaplan J. (2005)
    2. Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (2010)
    3. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. (PubMed id 17261583)1, 2 Ma Y.M.... Kirchhausen T. (2007)
    4. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. (PubMed id 14519844)1, 2 Martin-Serrano J.... Bieniasz P.D. (2003)
    7. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PubMed id 11559748)1, 3 Howard T.L....Hollenberg S.M. (2001)
    8. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    9. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51510 HGNC: 26942 AceView: SNF7DC2 Ensembl:ENSG00000086065 euGenes: HUgn51510
    ECgene: CHMP5 Kegg: 51510 H-InvDB: CHMP5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHMP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHMP5 gene:
    Search GeneIP for patents involving CHMP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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