CHMP4B Gene
protein-coding GIFtS: 57
GCID: GC20P032399
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|
charged multivesicular body protein 4B(Previous names: chromosome 20 open reading frame 178, chromatin modifying...)
(Previous symbol: C20orf178)
| |
Aliases
for CHMP4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Charged Multivesicular Body Protein 4B1 2 | | HVps32-21 | | C20orf1781 2 3 | | SNF7 Homolog Associated With Alix 12 3 | | SNF7-21 2 3 | | CTPP32 5 | | Shax11 2 | | SNF72 5 | | VPS32B1 2 | | Chromosome 20 Open Reading Frame 1781 | | Chromatin Modifying Protein 4B1 2 | | CHMP4A2 | | DJ553F4.41 | | Snf7 Homologue Associated With Alix 12 | | Chromatin-Modifying Protein 4b2 3 | | Vacuolar Protein-Sorting-Associated Protein 32-22 | | Vacuolar Protein Sorting-Associated Protein 32-22 3 | | CHMP4b3 | | Vps32-22 3 | | SHAX13 | | HSnf7-21 | | |
Export aliases for CHMP4B gene to outside databasesPrevious GC identifers: GC20P031863 GC20P029183 |
Summaries
for CHMP4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHMP4B:
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) proteinfamily. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III),which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRTmachinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such asHIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP,also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed tohelp generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominantposterior polar cataracts.(provided by RefSeq, Oct 2009)
UniProtKB/Swiss-Prot: CHM4B_HUMAN, Q9H444Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which isinvolved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs containintraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of theendosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growthfactor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV isreleased. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminalstages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins arebelieved to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction withthe AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote orstabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- andp9-dependent virus release
Gene Wiki entry for CHMP4B
|
Genomic Views
for CHMP4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011362.10
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHMP4B gene promoter:
Bach1 NRSF form 1 HNF-4alpha2 NRSF form 2 HNF-4alpha1 YY1 MZF-1 PPAR-gamma1 c-Myb PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHMP4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q11.22 Ensembl cytogenetic band: 20q11.22 HGNC cytogenetic band: 20q11.22CHMP4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P032399: view genomic region
(about GC identifiers)
Start:
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32,399,110 bp from pter |
End:
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32,442,173 bp from pter |
Size:
|
43,064 bases |
Orientation:
|
plus strand |
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Proteins
for CHMP4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHM4B_HUMAN, Q9H444 (See
protein sequence)Recommended Name: Charged multivesicular body protein 4b Size: 224 amino acids; 24950 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-IIIcomponents are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Severalassembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with CHMP6 and CHMP4C. Interactswith PDCD6IP; the interaction is direct. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; theinteraction is direct. Interacts with CHMP7. Interacts with CFTR; the interaction requires misfolded CFTR
Subcellular location: Cytoplasm, cytosol. Late endosome membrane; Peripheral membrane protein (Probable)
Miscellaneous: Its overexpression strongly inhibits HIV-1 release
3 PDB 3D structures from  and Proteopedia  for CHMP4B:3C3Q (3D)
3UM3 (3D)
4ABM (3D)
Secondary accessions: E1P5N4 Q53ZD6Explore the universe of human proteins at neXtProt for CHMP4B: NX_Q9H444
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H444
CHMP4B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_789782.1
ENSEMBL proteins: ENSP00000217402 Reactome Protein details: Q9H444
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- | | GO:0031902 | late endosome membrane |
IEA | -- |
CHMP4B for ontologies About GeneDecksing
CHMP4B Antibody Products:
Assay Products for CHMP4B: |
Protein
Domains /
Families
for CHMP4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHMP4B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H444ProtoNet protein and cluster: Q9H444 1 Blocks protein family: IPB005024 Eukaryotic protein of unknown function DUF279
UniProtKB/Swiss-Prot: CHM4B_HUMAN, Q9H444Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble andinactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, whichenables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners,probably including other ESCRT componentsSimilarity: Belongs to the SNF7 family |
Function
for CHMP4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CHM4B_HUMAN, Q9H444Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which isinvolved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs containintraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of theendosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growthfactor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV isreleased. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminalstages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins arebelieved to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction withthe AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote orstabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- andp9-dependent virus release
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP4B (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP4B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
CHMP4B for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CHMP4B:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Chmp4b):
CHMP4B for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHMP4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Membrane Trafficking | | | 2 | Endocytosis | | | 3 | Normal wtCFTR traffic / Sorting endosome formation | | | 4 | Clathrin-dependent protein traffic | | | 5 | Signal Transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2  GeneGo (Thomson Reuters) Pathways for CHMP4B
2 
Reactome Pathways for CHMP4B
1 
Kegg Pathway (Kegg details for CHMP4B):
CHMP4B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHMP4B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/51 Interacting proteins for CHMP4B (Q9H4442, 3 ENSP000002174024) via UniProtKB, MINT, STRING, and/or I2D (see all 51)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015031 | protein transport |
IEA | -- | | GO:0016044 | cellular membrane organization |
TAS | -- | | GO:0016197 | endosomal transport |
TAS | -- |
CHMP4B for ontologies About GeneDecksing
|
Drugs & Compounds
for CHMP4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CHMP4B
Search CenterWatch for drugs/clinical trials and news about CHMP4B / CHM4B
|
Transcripts
for CHMP4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHMP4B gene: NM_176812.4 Unigene Cluster for CHMP4B: Charged multivesicular body protein 4B Hs.472471 [show with all ESTs]Unigene Representative Sequence: BU1503151 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000217402(uc002xaa.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP4B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP4B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHMP4B (NM_176812) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHMP4B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP4B |
Additional cDNA sequence: AB100261.1 AY329085.1 AY726594.1 BC033859.1 8 DOTS entries: DT.92338471 DT.75102292 DT.100041697 DT.100646924 DT.100830338 DT.86840033 DT.97855636 DT.97856222 24/308 AceView cDNA sequences (see all 308): BU678563 BM683804 R70779 AW000887 BF476328 CR623996 CR616273 BM662707 CK299196 CR601594 BC033859 BU730441 CR592058 AI679899 BM764311 BE829860 BM761739 AJ705441 AA907442 CR607577 BQ227872 AB100261 BM850170 CR610271
GeneLoc Exon Structure
|
Expression
for CHMP4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHMP4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTGCACCT
About this image
See CHMP4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHMP4B
SOURCE GeneReport for Unigene cluster: Hs.472471
UniProtKB/Swiss-Prot: CHM4B_HUMAN, Q9H444Tissue specificity: Widely expressed. Expressed at higher level in heart and skeletal muscle. Also expressed in brain,colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood lymphocytes
SABiosciences Custom PCR Arrays for CHMP4B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHMP4B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP4B |
Orthologs
for CHMP4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CHMP4B gene from 9/35 species (see all 35) About this table
ENSEMBL Gene Tree for CHMP4B (if available)
TreeFam Gene Tree for CHMP4B (if available) |
Paralogs
for CHMP4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHMP4B gene
- CHMP4C2 CHMP4A2
3 SIMAP similar genes for CHMP4B using alignment to 1 protein entry: CHM4B_HUMAN:TM9SF1 CHMP4C CHMP4A
CHMP4B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CHMP4B
PGOHUM00000248177
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Genomic Variants
for CHMP4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHMP4B (32399110 - 32442173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHMP4B: --
Human Gene Mutation Database (HGMD): CHMP4B
Locus Specific Mutation Databases (LSDB): CHMP4B
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHMP4B |
|
Disorders
/ Diseases
for CHMP4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHMP4B for disorders About GeneDecksing
OMIM gene information: 610897
OMIM disorders: 605387
UniProtKB/Swiss-Prot: CHM4B_HUMAN, Q9H444
Defects in CHMP4B are the cause of cataract posterior polar type 3 (CTPP3) [MIM:605387]. A subcapsularopacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity
8  diseases for CHMP4B: About MalaCardscataract, posterior polar, 3 cataract posterior polar cataract congenital cataracts
mumps conjunctivitis immunodeficiency malaria
1 disease from the University of Copenhagen DISEASES database for CHMP4B:Mumps Export disorders for CHMP4B gene to outside databases
|
Publications
for CHMP4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHMP4B gene, integrated from 9 sources (see all 45):
(articles sorted by number of sources associating them with CHMP4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. (PubMed id 14678797)1, 2, 3, 9 Katoh K....Maki M. (2004)
- Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. (PubMed id 18209100)1, 2, 9 Hanson P.I....Heuser J.E. (2008)
- CHMP4B, a novel gene for autosomal dominant cataracts linked to chromosome 20q. (PubMed id 17701905)1, 2, 9 Shiels A.... Hanson P.I. (2007)
- Structure and function of human Vps20 and Snf7 proteins. (PubMed id 14583093)1, 2, 9 Peck J.W.... Burbelo P.D. (2004)
- ALIX-CHMP4 interactions in the human ESCRT pathway. (PubMed id 18511562)1, 2 McCullough J....Hill C.P. (2008)
- Brox, a novel farnesylated Bro1 domain-containing protein that associates with charged multivesicular body protein 4 (CHMP4). (PubMed id 18190528)1, 2 Ichioka F.... Maki M. (2008)
- Potent rescue of human immunodeficiency virus type 1 late domain mutants by ALIX/AIP1 depends on its CHMP4 binding site. (PubMed id 17428861)1, 2 Usami Y....Gottlinger H.G. (2007)
- Human CHMP6, a myristoylated ESCRT-III protein, interacts directly with an ESCRT-II component EAP20 and regulates endosomal cargo sorting. (PubMed id 15511219)1, 2 Yorikawa C....Maki M. (2005)
- Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes. (PubMed id 15007060)1, 2 Sharma M.... Lukacs G.L. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for CHMP4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHMP4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHMP4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHMP4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHMP4B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CHMP4B gene:
Search GeneIP for patents involving CHMP4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHMP4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHMP4B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHMP4B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHMP4B | | | OriGene Protein Over-expression Lysate for CHMP4B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHMP4B | | OriGene 3'-UTR Clone for CHMP4B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP4B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP4B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CHMP4B | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHMP4B | | OriGene Custom Protein Services for CHMP4B | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHMP4B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHMP4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHMP4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHMP4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHMP4B |
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| | | | Search Tocris compounds for CHMP4B |
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 | | | CHMP4B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP4B |
|  |  |  | | | | ThermoFisher Antibody for CHMP4B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP4B |
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