Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHMP4A Gene

Aliases for CHMP4A Gene

  • Charged Multivesicular Body Protein 4A 2 3
  • Vacuolar Protein Sorting-Associated Protein 32-1 3 4
  • SNF7 Homolog Associated With Alix-2 3 4
  • Chromatin Modifying Protein 4A 2 3
  • C14orf123 3 4
  • VPS32-1 3 4
  • SNF7-1 3 4
  • SHAX2 3 4
  • SNF7 3 6
  • Snf7 Homologue Associated With Alix 2 3
  • Chromosome 14 Open Reading Frame 123 2
  • Chromatin-Modifying Protein 4a 4
  • HVps32-1 4
  • HSPC134 3
  • CHMP4B 3
  • VPS32A 3
  • CHMP4a 4
  • HSnf-1 4
  • CHMP4 3

External Ids for CHMP4A Gene

Previous Symbols for CHMP4A Gene

  • C14orf123

Summaries for CHMP4A Gene

Entrez Gene Summary for CHMP4A Gene

  • CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHMP4A Gene

CHMP4A (Charged Multivesicular Body Protein 4A) is a Protein Coding gene. Diseases associated with CHMP4A include hiv-1. Among its related pathways are Disease and Endocytosis. GO annotations related to this gene include lipid binding. An important paralog of this gene is CHMP4B.

UniProtKB/Swiss-Prot for CHMP4A Gene

  • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.

Gene Wiki entry for CHMP4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHMP4A Gene

Genomics for CHMP4A Gene

Genomic Location for CHMP4A Gene

Start:
24,209,581 bp from pter
End:
24,213,869 bp from pter
Size:
4,289 bases
Orientation:
Minus strand

Genomic View for CHMP4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHMP4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHMP4A Gene

Regulatory Elements for CHMP4A Gene

Proteins for CHMP4A Gene

  • Protein details for CHMP4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY43-CHM4A_HUMAN
    Recommended name:
    Charged multivesicular body protein 4a
    Protein Accession:
    Q9BY43
    Secondary Accessions:
    • Q14D22
    • Q32Q79
    • Q86SZ8
    • Q96QJ9
    • Q9P026

    Protein attributes for CHMP4A Gene

    Size:
    222 amino acids
    Molecular mass:
    25098 Da
    Quaternary structure:
    • Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Self-associates; overexpression leads to the assembly of filaments that curve and associate to create circular rings. Interacts with CHMP2A. Interacts with CHMP3; the interaction requires the release of CHMP4A autoinhibition. Interacts with CHMP4B. Interacts with CHMP4C. Interacts with CHMP6. Interacts with VPS4A. Interacts with PDCD6IP; the interaction is direct.
    SequenceCaution:
    • Sequence=AAH10893.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07700.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD61949.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHMP4A Gene

    Alternative splice isoforms for CHMP4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHMP4A Gene

Proteomics data for CHMP4A Gene at MOPED

Post-translational modifications for CHMP4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHMP4A Gene

No data available for DME Specific Peptides for CHMP4A Gene

Domains for CHMP4A Gene

Gene Families for CHMP4A Gene

HGNC:
  • CHMP :Charged multivesicular body proteins

Protein Domains for CHMP4A Gene

UniProtKB/Swiss-Prot:

CHM4A_HUMAN
Domain:
  • The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners, probably including other ESCRT components (By similarity).:
    • Q9BY43
Family:
  • Belongs to the SNF7 family.:
    • Q9BY43
genes like me logo Genes that share domains with CHMP4A: view

Function for CHMP4A Gene

Molecular function for CHMP4A Gene

UniProtKB/Swiss-Prot Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.

Gene Ontology (GO) - Molecular Function for CHMP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14505570
GO:0008289 lipid binding IEA --
GO:0042802 identical protein binding IMP 18209100
GO:0042803 protein homodimerization activity IPI 14519844
GO:0051117 ATPase binding IPI 18209100
genes like me logo Genes that share ontologies with CHMP4A: view

Phenotypes for CHMP4A Gene

GenomeRNAi human phenotypes for CHMP4A:
genes like me logo Genes that share phenotypes with CHMP4A: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHMP4A Gene

Localization for CHMP4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHMP4A Gene

Cytoplasmic vesicle membrane. Late endosome membrane; Peripheral membrane protein. Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHMP4A Gene COMPARTMENTS Subcellular localization image for CHMP4A gene
Compartment Confidence
endosome 5
cytosol 4
nucleus 2
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CHMP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000815 ESCRT III complex IDA 21975012
GO:0005634 nucleus IDA 21975012
GO:0005737 cytoplasm IDA 21975012
GO:0005768 colocalizes_with endosome IDA 24878737
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHMP4A: view

Pathways for CHMP4A Gene

genes like me logo Genes that share pathways with CHMP4A: view

Pathways by source for CHMP4A Gene

1 KEGG pathway for CHMP4A Gene

Gene Ontology (GO) - Biological Process for CHMP4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000920 cell separation after cytokinesis IMP 20616062
GO:0006620 posttranslational protein targeting to membrane IMP 21975012
GO:0006900 membrane budding IMP 18209100
GO:0006997 nucleus organization IMP 20616062
GO:0007034 vacuolar transport IEA --
genes like me logo Genes that share ontologies with CHMP4A: view

Transcripts for CHMP4A Gene

mRNA/cDNA for CHMP4A Gene

Unigene Clusters for CHMP4A Gene

Charged multivesicular body protein 4A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHMP4A Gene

No ASD Table

Relevant External Links for CHMP4A Gene

GeneLoc Exon Structure for
CHMP4A
ECgene alternative splicing isoforms for
CHMP4A

Expression for CHMP4A Gene

mRNA expression in normal human tissues for CHMP4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHMP4A Gene

SOURCE GeneReport for Unigene cluster for CHMP4A Gene Hs.279761

mRNA Expression by UniProt/SwissProt for CHMP4A Gene

Q9BY43-CHM4A_HUMAN
Tissue specificity: Widely expressed. Expressed at higher level in heart, kidney, liver and skeletal muscle. Also expressed in brain, placenta, lung and pancreas.
genes like me logo Genes that share expressions with CHMP4A: view

Orthologs for CHMP4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHMP4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHMP4A 36
  • 99.87 (n)
  • 99.62 (a)
cow
(Bos Taurus)
Mammalia CHMP4A 36
  • 91.44 (n)
  • 91.44 (a)
CHMP4A 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHMP4A 36
  • 85.42 (n)
  • 83.27 (a)
oppossum
(Monodelphis domestica)
Mammalia CHMP4A 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHMP4A 37
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta shrb 37
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea vps-32.1 37
  • 54 (a)
ManyToMany
vps-32.2 37
  • 51 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF7 37
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6410 37
  • 51 (a)
OneToMany
Species with no ortholog for CHMP4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CHMP4A Gene

ENSEMBL:
Gene Tree for CHMP4A (if available)
TreeFam:
Gene Tree for CHMP4A (if available)

Paralogs for CHMP4A Gene

Paralogs for CHMP4A Gene

Selected SIMAP similar genes for CHMP4A Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for CHMP4A Gene

genes like me logo Genes that share paralogs with CHMP4A: view

Variants for CHMP4A Gene

Sequence variations from dbSNP and Humsavar for CHMP4A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1063799 -- 24,209,739(-) AGGGT(C/T)TCTTA utr-variant-3-prime
rs1242014 -- 24,209,175(-) CTACT(C/T)GGAAT downstream-variant-500B
rs1242015 -- 24,209,144(-) CTACT(C/T)GGAAT downstream-variant-500B
rs2295321 -- 24,210,799(-) GTTGC(A/G)TGATT intron-variant
rs2295322 - 24,210,671(-) GCTTT(A/G)GAGAT missense, reference

Relevant External Links for CHMP4A Gene

HapMap Linkage Disequilibrium report
CHMP4A

No data available for Structural Variations from Database of Genomic Variants (DGV) for CHMP4A Gene

Disorders for CHMP4A Gene

(1) MalaCards Diseases for CHMP4A Gene

Search for CHMP4A Gene in MalaCards »

(1) University of Copenhagen DISEASES for CHMP4A Gene

genes like me logo Genes that share disorders with CHMP4A: view

No data available for UniProtKB/Swiss-Prot for CHMP4A Gene

Publications for CHMP4A Gene

  1. The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. (PMID: 12860994) Katoh K. … Maki M. (J. Biol. Chem. 2003) 3 4 23
  2. Structure and function of human Vps20 and Snf7 proteins. (PMID: 14583093) Peck J.W. … Burbelo P.D. (Biochem. J. 2004) 3 4 23
  3. CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. (PMID: 14678797) Katoh K. … Maki M. (Arch. Biochem. Biophys. 2004) 3 4 23
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain. (PMID: 17547705) Shim S. … Hanson P.I. (Traffic 2007) 3 4

Products for CHMP4A Gene

Sources for CHMP4A Gene

Back to Top

Content