Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CHMP4A Gene

protein-coding   GIFtS: 53
GCID: GC14M024678

Charged Multivesicular Body Protein 4A

(Previous names: chromosome 14 open reading frame 123, chromatin modifying...)
(Previous symbol: C14orf123)
  Search for CHMP4A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Charged Multivesicular Body Protein 4A1 2     CHMP4B2
C14orf1231 2 3     HSPC1342
Chromatin Modifying Protein 4A1 2     VPS32-12
Vacuolar Protein Sorting-Associated Protein 32-12 3     VPS32A2
SHAX22 3     Snf7 Homologue Associated With Alix 22
SNF7-12 3     CHMP4a3
SNF7 Homolog Associated With Alix-22 3     Vps32-13
SNF72 5     Chromatin-Modifying Protein 4a3
Chromosome 14 Open Reading Frame 1231     hSnf-13
CHMP42     hVps32-13

External Ids:    HGNC: 202741   Entrez Gene: 290822   Ensembl: ENSG000002545057   OMIM: 6100515   UniProtKB: Q9BY433   

Export aliases for CHMP4A gene to outside databases

Previous GC identifers: GC14M023749 GC14M004793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CHMP4A Gene:
CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These
proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved
in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs
have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required
for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).(supplied
by OMIM, Mar 2008)

GeneCards Summary for CHMP4A Gene:
CHMP4A (charged multivesicular body protein 4A) is a protein-coding gene. GO annotations related to this gene include lipid binding. An important paralog of this gene is CHMP4B.

UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs
contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane
of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as
stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the
sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the
invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent
membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1
and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or
membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed,
membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward
budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release

Gene Wiki entry for CHMP4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHMP4A gene promoter:
         RFX1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   Nkx5-1   POU3F2   GATA-1   CREB   deltaCREB   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHMP4A promoter sequence
   Search Chromatin IP Primers for CHMP4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHMP4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

CHMP4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP4A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024678:  view genomic region     (about GC identifiers)

Start:
24,678,787 bp from pter      End:
24,683,075 bp from pter
Size:
4,289 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43 (See protein sequence)
Recommended Name: Charged multivesicular body protein 4a  
Size: 222 amino acids; 25098 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III).
ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome.
Several assembly forms of ESCRT-III may exist that interact and act sequentally. Self-associates; overexpression
leads to the assembly of filaments that curve and associate to create circular rings. Interacts with CHMP2A.
Interacts with CHMP3; the interaction requires the release of CHMP4A autoinhibition. Interacts with CHMP4B.
Interacts with CHMP4C. Interacts with CHMP6. Interacts with VPS4A. Interacts with PDCD6IP; the interaction is
direct
Sequence caution: Sequence=AAH10893.2; Type=Erroneous initiation; Sequence=AAI07700.1; Type=Erroneous initiation;
Sequence=CAD61949.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CHMP4A:
3C3O (3D)    
Secondary accessions: Q32Q79 Q86SZ8 Q96QJ9 Q9P026

Explore the universe of human proteins at neXtProt for CHMP4A: NX_Q9BY43

Explore proteomics data for CHMP4A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CHMP4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054888.2  
    ENSEMBL proteins: 
     ENSP00000324205   ENSP00000449757   ENSP00000436224   ENSP00000476412   ENSP00000432575  
     ENSP00000448869  
    Reactome Protein details: Q9BY43

    CHMP4A Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CHMP4A
    Browse OriGene Protein Over-expression Lysates
    OriGene MassSpec for CHMP4A
    OriGene Custom Protein Services for CHMP4A
    GenScript Custom Purified and Recombinant Proteins Services for CHMP4A
    Novus Biologicals CHMP4A Proteins
    Novus Biologicals CHMP4A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CHMP4A
    Cloud-Clone Corp. Proteins for CHMP4A

     
    Search eBioscience for Proteins for CHMP4A 

    CHMP4A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHMP4A
    Novus Biologicals CHMP4A Antibodies
    Abcam antibodies for CHMP4A
    Cloud-Clone Corp. Antibodies for CHMP4A
    Search ThermoFisher Antibodies for CHMP4A
    LSBio Antibodies in human, mouse, rat for CHMP4A

    CHMP4A Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHMP4A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHMP4A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHMP4A
    Cloud-Clone Corp. CLIAs for CHMP4A
    Search eBioscience for ELISAs for CHMP4A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CHMP: Charged multivesicular body proteins

    1 InterPro protein domain:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry Q9BY43

    ProtoNet protein and cluster: Q9BY43

    1 Blocks protein domain: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43
    Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and
    inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation,
    which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding
    partners, probably including other ESCRT components (By similarity)
    Similarity: Belongs to the SNF7 family


    Find genes that share domains with CHMP4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHM4A_HUMAN, Q9BY43
    Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
    involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs
    contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane
    of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as
    stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the
    sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the
    invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent
    membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1
    and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or
    membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed,
    membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward
    budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--
         
    Find genes that share ontologies with CHMP4A           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CHMP4A:
     Increased cell number in G2M,  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHMP4A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHMP4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHMP4A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHMP4A

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CHMP4A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CHMP4A:
    hsa-miR-4328 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidCHMP4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHMP4A
    Predesigned siRNA for gene silencing in human, mouse, rat CHMP4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHMP4A

    Clone
    Products:
         
    OriGene clones in human, mouse for CHMP4A (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHMP4A (NM_014169)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP4A

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHMP4A
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHMP4A 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP4A

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12046) for CHMP4A 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CHM4A_HUMAN, Q9BY43: Cytoplasmic vesicle membrane. Late endosome membrane; Peripheral membrane protein
    (Probable). Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of
    dividing cells. Localized in two distinct rings on either side of the Fleming body
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    cytosol4
    nucleus2
    lysosome1
    mitochondrion1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0030496midbody IDA--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031902late endosome membrane IEA--

    Find genes that share ontologies with CHMP4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CHMP4A About    
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Endocytosis
    Endocytosis
    5Disease
    Disease


    Find genes that share SuperPaths with CHMP4A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for CHMP4A
        Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for CHMP4A):
        Endocytosis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHMP4A
    Interactions:

        GeneGlobe Interaction Network for CHMP4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHMP4A (Q9BY432, 3 ENSP000003242054) via UniProtKB, MINT, STRING, and/or I2D (see all 100)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP54Q70EL12, 3, ENSP000003452164MINT-6947321 I2D: score=1 STRING: ENSP00000345216
    CHMP2AO436333, ENSP000003104404I2D: score=4 STRING: ENSP00000310440
    ATP6V1E1P365433, ENSP000002534134I2D: score=1 STRING: ENSP00000253413
    CC2D1AQ6P1N03, ENSP000003136014I2D: score=1 STRING: ENSP00000313601
    KIAA0368Q5VYK33, ENSP000002593354I2D: score=1 STRING: ENSP00000259335
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016032viral process TAS--
    GO:0016197endosomal transport TAS--
    GO:0019058viral life cycle TAS--
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with CHMP4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHMP4A (CHM4A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CHMP4A gene: 
    NM_014169.3  

    Unigene Cluster for CHMP4A:

    Charged multivesicular body protein 4A
    Hs.279761  [show with all ESTs]
    Unigene Representative Sequence: AK094345
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347519 ENST00000530996 ENST00000533523 ENST00000542700 ENST00000609024
    ENST00000533011 ENST00000524955 ENST00000552620 ENST00000534106 ENST00000527154
    ENST00000531158
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHMP4A using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CHMP4A:
    hsa-miR-4328 hsa-miR-1271 hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidCHMP4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHMP4A
    Predesigned siRNA for gene silencing in human, mouse, rat CHMP4A
    Clone
    Products:
         
    OriGene clones in human, mouse for CHMP4A (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHMP4A (NM_014169)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP4A
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHMP4A
    OriGene qSTAR qPCR primer pairs in human, mouse for CHMP4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CHMP4A
      QuantiTect SYBR Green Assays in human, mouse, rat CHMP4A
      QuantiFast Probe-based Assays in human, mouse, rat CHMP4A
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12046) for CHMP4A 

    Additional mRNA sequence: 

    AB100262.2 AF161483.1 AF212243.1 AK094345.1 AY329084.1 BC010893.1 BC107699.1 BC113533.1 
    BC113535.1 BC143834.1 

    14 DOTS entries:

    DT.100696524  DT.411394  DT.95228148  DT.91741494  DT.100782668  DT.100042051  DT.100811330  DT.100811331 
    DT.120731609  DT.100811332  DT.120731519  DT.120731524  DT.120731555  DT.92420959 

    Selected AceView cDNA sequences (see all 554):

    BM565531 BQ652841 BM710198 BM553019 CF130271 F36177 AI478360 BM920212 
    AI354437 BX161512 AK092821 CD519487 BG327102 AI700544 CB306090 BC064899 
    BE395591 CA867065 BC051382 BM507263 CF130176 AI032042 BC046912 BP432799 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CHMP4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGGGTGG
    CHMP4A Expression
    About this image


    CHMP4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Kidney (Urinary System)
    CHMP4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHMP4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279761

    UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43
    Tissue specificity: Widely expressed. Expressed at higher level in heart, kidney, liver and skeletal muscle. Also
    expressed in brain, placenta, lung and pancreas

        Custom PCR Arrays for CHMP4A
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHMP4A
    OriGene qSTAR qPCR primer pairs in human, mouse for CHMP4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CHMP4A
    QuantiTect SYBR Green Assays in human, mouse, rat CHMP4A
    QuantiFast Probe-based Assays in human, mouse, rat CHMP4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHMP4A gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CHMP4A1 charged multivesicular body protein 4A 85.42(n)
    83.27(a)
      480263  XM_005623268.1  XP_005623325.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHMP4A6
    charged multivesicular body protein 4A
    72(a)
    1 ↔ 1
    AAWZ02037795(3613-9894)
    fruit fly
    (Drosophila melanogaster)
    Insecta shrb6
    shrub
    51(a)
    1 → many
    2R(5029651-5031415)
    worm
    (Caenorhabditis elegans)
    Secernentea vps-32.16
    vps-32.26
    Protein VPS-32.2 (vps-32.2) mRNA, complete cds
    54(a)
    51(a)
    many ↔ many
    many ↔ many
    II(6589290-6591086) WBGene00016961
    V(7849984-7851029) WBGene00016497
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNF76
    One of four subunits of the endosomal sorting comp...
    37(a)
    1 → many
    XII(194452-195174) YLR025W


    ENSEMBL Gene Tree for CHMP4A (if available)
    TreeFam Gene Tree for CHMP4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CHMP4A gene
    CHMP4B2  CHMP4C2  
    5 SIMAP similar genes for CHMP4A using alignment to 6 protein entries:     CHM4A_HUMAN (see all proteins):
    TM9SF1    CHMP4B    CHMP4C    CHMP4BP1    CHMP6

    Find genes that share paralogs with CHMP4A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CHMP4A
    PGOHUM00000258128


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CHMP4A (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80072721,2
    C,A--24678288(+) ATTCCG/AAGTAG 1 -- int12Minor allele frequency- A:0.25WA NA 4
    rs1136570631,2
    C--24678319(+) ATTCCG/AAGTAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs12420151,2
    C,A--24678350(-) CTACTC/TGGAAT 1 -- int10--------
    rs12420141,2
    C,F--24678381(-) CTACTT/CGGAAT 1 -- int13Minor allele frequency- C:0.33NA 6
    rs80068161,2
    C,A--24678411(+) CATTCC/AAAGTA 1 -- int12Minor allele frequency- A:0.00NA 4
    rs1133471011,2
    C--24678412(+) ATTCCG/AAGTAG 1 -- int11Minor allele frequency- A:0.00NA 2
    rs590336231,2
    C--24678443(+) ATTCCG/AAGTAG 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1123906171,2
    C,F--24678485(+) CCTCCT/CTGTCC 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs1468049111,2
    C--24678647(+) CAAACC/TGGCTT 1 -- int10--------
    rs1489531841,2
    --24678657(+) TGAAAA/GATGAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for CHMP4A (24678787 - 24683075 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CHMP4A: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CHMP4A
    DNA2.0 Custom Variant and Variant Library Synthesis for CHMP4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610051    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CHMP4A:
    Mumps

    Find genes that share disorders with CHMP4A           About GenesLikeMe


    Export disorders for CHMP4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CHMP4A gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with CHMP4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. (PubMed id 12860994)1, 2, 9 Katoh K.... Maki M. (J. Biol. Chem. 2003)
    2. CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. (PubMed id 14678797)1, 2, 9 Katoh K.... Maki M. (Arch. Biochem. Biophys. 2004)
    3. Structure and function of human Vps20 and Snf7 proteins. (PubMed id 14583093)1, 2, 9 Peck J.W.... Burbelo P.D. (Biochem. J. 2004)
    4. Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. (PubMed id 18209100)1, 2 Hanson P.I.... Heuser J.E. (J. Cell Biol. 2008)
    5. ALIX-CHMP4 interactions in the human ESCRT pathway. (PubMed id 18511562)1, 2 McCullough J.... Hill C.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain. (PubMed id 17547705)1, 2 Shim S.... Hanson P.I. (Traffic 2007)
    7. Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. (PubMed id 15632132)1, 2 Lin Y.... Hanson P.I. (J. Biol. Chem. 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (Cell 2003)
    10. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. (PubMed id 14505569)1, 2 Strack B.... Goettlinger H.G. (Cell 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29082 HGNC: 20274 AceView: NEDD8 Ensembl:ENSG00000254505 euGenes: HUgn29082
    ECgene: CHMP4A Kegg: 29082 H-InvDB: CHMP4A

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CHMP4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CHMP4A gene:
    Search GeneIP for patents involving CHMP4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHMP4A  
     OriGene qPCR primer pairs and template standards for CHMP4A   Browse OriGene Protein Over-expression Lysates  
     OriGene MassSpec something-or-other for CHMP4A   OriGene clones in human, mouse for CHMP4A  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHMP4A   OriGene Purified Protein for CHMP4A  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHMP4A   OriGene Custom Protein Services for CHMP4A  

     
     
     Block miRNA regulation of human, mouse, rat CHMP4A using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CHMP4A
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHMP4A Predesigned siRNA for gene silencing in human, mouse, rat CHMP4A
     QuantiFast Probe-based Assays in human, mouse, rat CHMP4A QuantiTect SYBR Green Assays in human, mouse, rat CHMP4A
     Custom PCR Arrays for CHMP4A Search Chromatin IP Primers for CHMP4A
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CHMP4A  GeneGlobe Interaction Network for CHMP4A
     Regulatory tfbs in CHMP4A promoter
     GenScript Custom Purified and Recombinant Proteins Services for CHMP4A GenScript cDNA clones with any tag delivered in your preferred vector for CHMP4A
     GenScript Custom Assay Services for CHMP4A GenScript Custom overexpressing Cell Line Services for CHMP4A
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CHMP4A (CHM4A)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CHMP4A antibodies
     CHMP4A proteins
     CHMP4A lysates
     Antibodies for CHMP4A
     See all of Abcam's Antibodies, Kits and Proteins for CHMP4A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for CHMP4A
     Proteins for CHMP4A
     Antibodies for CHMP4A
     ELISAs for CHMP4A
     CLIAs for CHMP4A



     Browse ESI BIO Cell Lines and PureStem Progenitors for CHMP4A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP4A
     SwitchGear 3'UTR luciferase reporter plasmids for CHMP4A
     SwitchGear Promoter luciferase reporter plasmids for CHMP4A
     Search ThermoFisher Antibodies for CHMP4A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP4A
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHMP4A
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHMP4A
     LSBio Antibodies in human, mouse, rat for CHMP4A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CHMP4A
      Search eBioscience for proteins for CHMP4A
      Search eBioscience for elisas for CHMP4A
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHMP4A gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4