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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHMP4A Gene

protein-coding   GIFtS: 52
GCID: GC14M024678

charged multivesicular body protein 4A

(Previous names: chromosome 14 open reading frame 123, chromatin modifying...)
(Previous symbol: C14orf123)
 Explore 5 diseases affiliated with
CHMP4A via our new
 Human Malady Compendium 
Biological research products
for CHMP4A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Charged Multivesicular Body Protein 4A1 2     Chromosome 14 Open Reading Frame 1231
C14orf1231 2 3     CHMP42
HSPC1341 2     CHMP4B2
VPS32A1 2     VPS32-12
Chromatin Modifying Protein 4A1 2     Snf7 Homologue Associated With Alix 22
Vacuolar Protein Sorting-Associated Protein 32-12 3     CHMP4a3
SHAX22 3     Vps32-13
SNF7-12 3     Chromatin-Modifying Protein 4a3
SNF7 Homolog Associated With Alix-22 3     HSnf-11
SNF72 5     HVps32-11

External Ids:    HGNC: 202741   Entrez Gene: 290822   Ensembl: ENSG000002545057   OMIM: 6100515   UniProtKB: Q9BY433   

Export aliases for CHMP4A gene to outside databases

Previous GC identifers: GC14M023749 GC14M004793


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHMP4A:
CHMP4A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are
components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of
surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and
cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and
regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the
endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth
factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,
-I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is
released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal
stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are
believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with
the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or
stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and
p9-dependent virus release

Gene Wiki entry for CHMP4A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHMP4A gene promoter:
         RFX1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   Nkx5-1   POU3F2   GATA-1   CREB   deltaCREB   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHMP4A promoter sequence
   Search SABiosciences Chromatin IP Primers for CHMP4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q12

CHMP4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP4A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024678:  view genomic region     (about GC identifiers)

Start:
24,678,787 bp from pter      End:
24,683,185 bp from pter
Size:
4,399 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43 (See protein sequence)
Recommended Name: Charged multivesicular body protein 4a  
Size: 222 amino acids; 25098 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III
components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several
assembly forms of ESCRT-III may exist that interact and act sequentally. Self-associates; overexpression leads to the
assembly of filaments that curve and associate to create circular rings. Interacts with CHMP2A. Interacts with CHMP3;
the interaction requires the release of CHMP4A autoinhibition. Interacts with CHMP4B. Interacts with CHMP4C. Interacts
with CHMP6. Interacts with VPS4A. Interacts with PDCD6IP; the interaction is direct
Subcellular location: Cytoplasmic vesicle membrane. Late endosome membrane; Peripheral membrane protein (Probable).
Note=Membrane-associated. Localizes to large vesicle-like structures. Localizes to the midbody of dividing cells.
Localized in two distinct rings on either side of the Fleming body
Sequence caution: Sequence=AAH10893.2; Type=Erroneous initiation; Sequence=AAI07700.1; Type=Erroneous initiation;
Sequence=CAD61949.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for CHMP4A:
3C3O (3D)    
Secondary accessions: Q32Q79 Q86SZ8 Q96QJ9 Q9P026

Explore the universe of human proteins at neXtProt for CHMP4A: NX_Q9BY43

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BY43

  • CHMP4A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_054888.2  
    ENSEMBL proteins: 
     ENSP00000324205   ENSP00000448488   ENSP00000449757   ENSP00000436224   ENSP00000432575  
     ENSP00000448869  
    Reactome Protein details: Q9BY43
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for CHMP4A
    Uscn Proteins for CHMP4A

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0030659cytoplasmic vesicle membrane IEA--
    GO:0031902late endosome membrane IEA--


    CHMP4A for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CHMP4A


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CHMP4A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry Q9BY43

    ProtoNet protein and cluster: Q9BY43

    1 Blocks protein family: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43
    Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and
    inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which
    enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners,
    probably including other ESCRT components (By similarity)
    Similarity: Belongs to the SNF7 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43
    Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
    involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the
    endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth
    factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,
    -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is
    released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal
    stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are
    believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with
    the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or
    stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and
    p9-dependent virus release

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008289lipid binding IEA--


    CHMP4A for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CHMP4A:
     Increased cell number in G2M,  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Membrane Trafficking
    Membrane Trafficking1.00
    2Endocytosis
    Endocytosis1.00
    3Signal Transduction
    Endosomal Sorting Complex Required For Transport (ESCRT)0.14

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for CHMP4A
        Membrane Trafficking
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1         Kegg Pathway  (Kegg details for CHMP4A):
        Endocytosis


    CHMP4A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHMP4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for CHMP4A (Q9BY432, 3 ENSP000003242054) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP54Q70EL12, 3, ENSP000003452164MINT-6947321 I2D: score=1 STRING: ENSP00000345216
    CHMP2AO436333, ENSP000003104404I2D: score=4 STRING: ENSP00000310440
    CC2D1AQ6P1N03, ENSP000003136014I2D: score=1 STRING: ENSP00000313601
    PDCD6IPQ8WUM43, ENSP000003073874I2D: score=10 STRING: ENSP00000307387
    TTC19Q6DKK23, ENSP000002616474I2D: score=1 STRING: ENSP00000261647
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016044cellular membrane organization TAS--
    GO:0016197endosomal transport TAS--


    CHMP4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHMP4A
    Search CenterWatch for drugs/clinical trials and news about CHMP4A / CHM4A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHMP4A gene: 
    NM_014169.3  

    Unigene Cluster for CHMP4A:

    Charged multivesicular body protein 4A
    Hs.279761  [show with all ESTs]
    Unigene Representative Sequence: AK094345
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000347519 ENST00000548308 ENST00000530996 ENST00000533523 ENST00000542700
    ENST00000533011 ENST00000524955 ENST00000552620 ENST00000534106 ENST00000527154
    ENST00000531158

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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CHMP4A:
    hsa-miR-4328 hsa-miR-1271 hsa-miR-96
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    Additional cDNA sequence: 

    AB100262.2 AF161483.1 AF212243.1 AK094345.1 AY329084.1 BC010893.1 BC107699.1 BC113533.1 
    BC113535.1 BC143834.1 

    14 DOTS entries:

    DT.100696524  DT.411394  DT.95228148  DT.91741494  DT.100782668  DT.100042051  DT.100811330  DT.100811331 
    DT.120731609  DT.100811332  DT.120731519  DT.120731524  DT.120731555  DT.92420959 

    24/554 AceView cDNA sequences (see all 554):

    Z41108 AK125214 CD518977 AI148707 BQ061101 BM768317 BQ669080 BU856948 
    BQ652841 BG747497 AI703334 BE501663 BM841891 BQ549184 BM671619 BM825413 
    NM_138476 BU185091 BU157001 BM760325 CR624796 BQ962960 AI264682 CA867065 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHMP4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGAGGGTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CHMP4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHMP4A

    SOURCE GeneReport for Unigene cluster: Hs.279761

    UniProtKB/Swiss-Prot: CHM4A_HUMAN, Q9BY43
    Tissue specificity: Widely expressed. Expressed at higher level in heart, kidney, liver and skeletal muscle. Also
    expressed in brain, placenta, lung and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHMP4A gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia CHMP4A6
    --
    70(a)
    1 ↔ 1
    AAWZ02037795(5568-9894)
    fruit fly
    (Drosophila melanogaster)
    Insecta shrb6
    shrub
    52(a)
    1 → many
    2R(5029651-5031415)
    worm
    (Caenorhabditis elegans)
    Secernentea vps-32.16
    vps-32.26
    (see all 3)
    related to yeast Vacuolar Protein Sorting factor f...
    related to yeast Vacuolar Protein Sorting factor f...
    (see all 3)
    55(a)
    53(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    II(6589258-6591054)
    V(7849965-7851010)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SNF7.11 vacuolar protein sorting-associated protein 32-2 48.47(n)
    40.58(a)
      829037  NM_001084999.1  NP_001078468.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g02676001 hypothetical protein 49.2(n)
    42.31(a)
      4346566  NM_001069258.1  NP_001062723.1 


    ENSEMBL Gene Tree for CHMP4A (if available)
    TreeFam Gene Tree for CHMP4A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHMP4A gene
    CHMP4B2  CHMP4C2  
    4 SIMAP similar genes for CHMP4A using alignment to 7 protein entries:     CHM4A_HUMAN (see all proteins):
    TM9SF1    CHMP4B    CHMP4C    CHMP6

    CHMP4A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CHMP4A
    PGOHUM00000258128


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/122 NCBI SNPs in CHMP4A are shown (see all 122    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80072721,2
    C,A,--24678288(+) ATTCCG/AAGTAG 1 -- int12Minor allele frequency- A:0.25WA NA 4
    rs1136570631,2
    C,--24678319(+) ATTCCG/AAGTAG 1 -- int11Minor allele frequency- A:0.50NA 2
    rs12420151,2
    C,A--24678350(-) CTACTC/TGGAAT 1 -- int10--------
    rs12420141,2
    C,F--24678381(-) CTACTT/CGGAAT 1 -- int13Minor allele frequency- C:0.33NA 6
    rs80068161,2
    C,A--24678411(+) CATTCC/AAAGTA 1 -- int12Minor allele frequency- A:0.00NA 4
    rs590336231,2
    C,--24678443(+) ATTCCG/AAGTAG 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1123906171,2
    --24678485(+) CCTCCT/CTGTCC 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs1468049111,2
    --24678647(+) CAAACC/TGGCTT 1 -- int10--------
    rs1489531841,2
    --24678657(+) TGAAAA/GATGAA 1 -- int10--------
    rs125891571,2
    C,F,H,--24678784(+) GGAACA/CGCTTC 1 -- int121Minor allele frequency- N:0.01EA NA NS WA 2458

    HapMap Linkage Disequilibrium report for CHMP4A (24678787 - 24683185 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CHMP4A: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CHMP4A for disorders           About GeneDecksing

    OMIM gene information: 610051    OMIM disorders: --

    5 diseases for CHMP4A:    About MalaCards
    mumps    conjunctivitis    cataract    hypoxia
    malaria

    1 disease from the University of Copenhagen DISEASES database for CHMP4A:
    Mumps

    Export disorders for CHMP4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHMP4A gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with CHMP4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. (PubMed id 12860994)1, 2, 9 Katoh K.... Maki M. (2003)
    2. CHMP4b is a major binding partner of the ALG-2-interacting protein Alix among the three CHMP4 isoforms. (PubMed id 14678797)1, 2, 9 Katoh K....Maki M. (2004)
    3. Structure and function of human Vps20 and Snf7 proteins. (PubMed id 14583093)1, 2, 9 Peck J.W.... Burbelo P.D. (2004)
    4. Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. (PubMed id 18209100)1, 2 Hanson P.I....Heuser J.E. (2008)
    5. ALIX-CHMP4 interactions in the human ESCRT pathway. (PubMed id 18511562)1, 2 McCullough J....Hill C.P. (2008)
    6. Structure/function analysis of four core ESCRT-III proteins reveals common regulatory role for extreme C-terminal domain. (PubMed id 17547705)1, 2 Shim S....Hanson P.I. (2007)
    7. Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. (PubMed id 15632132)1, 2 Lin Y.... Hanson P.I. (2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)
    10. AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. (PubMed id 14505569)1, 2 Strack B.... Goettlinger H.G. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29082 HGNC: 20274 AceView: NEDD8 Ensembl:ENSG00000254505 euGenes: HUgn29082
    ECgene: CHMP4A Kegg: 29082 H-InvDB: CHMP4A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHMP4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHMP4A gene:
    Search GeneIP for patents involving CHMP4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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