Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHMP3 Gene

protein-coding   GIFtS: 51
GCID: GC02M086730

Charged Multivesicular Body Protein 3

(Previous names: vacuolar protein sorting 24 (yeast), vacuolar protein sorting...)
(Previous symbol: VPS24)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Charged Multivesicular Body Protein 31 2     Vacuolar Protein Sorting 24 Homolog (S. Cerevisiae)1
VPS241 2 3 5     25.1 Protein2
NEDF2 3 5     CHMP Family, Member 32
Chromatin-Modifying Protein 32 3     Vacuolar Protein Sorting 24 Homolog2
Neuroendocrine Differentiation Factor2 3     CGI1493
Vacuolar Protein Sorting-Associated Protein 242 3     hVps243
Vacuolar Protein Sorting 24 (Yeast)1     

External Ids:    HGNC: 298651   Entrez Gene: 516522   Ensembl: ENSG000001155617   OMIM: 6100525   UniProtKB: Q9Y3E73   

Export aliases for CHMP3 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHMP3 Gene:
This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body
(MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the
ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein
sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein
superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists
between this gene and the upstream ring finger protein 103 (RNF103) gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for CHMP3 Gene: 
CHMP3 (charged multivesicular body protein 3) is a protein-coding gene. Diseases associated with CHMP3 include non-small cell lung carcinoma, and conjunctivitis, and among its related super-pathways are HIV Life Cycle and Budding and maturation of HIV virion. GO annotations related to this gene include protein binding. An important paralog of this gene is RNF103-CHMP3.

UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs
contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane
of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as
stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the
sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the
invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent
membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1
and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or
membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to
phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides
tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor.
Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast
cells

Gene Wiki entry for CHMP3 (VPS24) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022184.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CHMP3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHMP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHMP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

CHMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M086730:  view genomic region     (about GC identifiers)

Start:
86,730,553 bp from pter      End:
86,948,245 bp from pter
Size:
217,693 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7 (See protein sequence)
Recommended Name: Charged multivesicular body protein 3  
Size: 222 amino acids; 25073 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III).
ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome.
Several assembly forms of ESCRT-III may exist that interact and act sequentally. Forms a metastable monomer in
solution; its core structure (without part of the putative autoinhibitory C-terminal acidic region) oligomerizes
into a flat lattice via two different dimerization interfaces. In vitro, heteromerizes with CHMP2A (but not
CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can
associate on the inside of the tubule. May interact with IGFBP7; the relevance of such interaction however
remains unclear. Interacts with CHMP2A. Interacts with CHMP4A; the interaction requires the release of CHMP4A
autoinhibition. Interacts with VPS4A. Interacts with STAMBP; the interaction appears to relieve the
autoinhibition of CHMP3
Subcellular location: Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane (Probable).
Note=Localizes to the midbody of dividing cells
Miscellaneous: Its overexpression strongly inhibits HIV-1 release
4 PDB 3D structures from and Proteopedia for CHMP3:
2GD5 (3D)        2XZE (3D)        3FRT (3D)        3FRV (3D)    
Secondary accessions: A8K3W0 B4DG34 B8ZZM0 B8ZZX5 Q3ZTS9 Q53S71 Q53SU5 Q9NZ51
Alternative splicing: 4 isoforms:  Q9Y3E7-1   Q9Y3E7-2   Q9Y3E7-3   Q9Y3E7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHMP3: NX_Q9Y3E7

Explore proteomics data for CHMP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y3E7

  • CHMP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHMP3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001005753.1  NP_001180446.1  NP_057163.1  

    ENSEMBL proteins: 
     ENSP00000263856   ENSP00000387045   ENSP00000386590   ENSP00000405575  
    Reactome Protein details: Q9Y3E7
    Human Recombinant Protein Products for CHMP3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CHMP3
    OriGene Protein Over-expression Lysate for CHMP3
    OriGene MassSpec for CHMP3 
    OriGene Custom Protein Services for CHMP3
    GenScript Custom Purified and Recombinant Proteins Services for CHMP3
    Novus Biologicals CHMP3 Proteins
    Novus Biologicals CHMP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome ----
    GO:0005829cytosol TAS--
    GO:0030496midbody ----
    GO:0031902late endosome membrane IEA--

    CHMP3 for ontologies           About GeneDecksing



    CHMP3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHMP3
    GenScript Custom Superior Antibodies Services for CHMP3
    Novus Biologicals CHMP3 Antibodies
    Abcam antibodies for CHMP3
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for CHMP3
    LSBio Antibodies in human, mouse, rat for CHMP3 

    Assay Products for CHMP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHMP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHMP3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHMP: Charged multivesicular body proteins

    1 InterPro protein domain:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry Q9Y3E7

    ProtoNet protein and cluster: Q9Y3E7

    1 Blocks protein domain: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7
    Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and
    inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation,
    which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding
    partners, probably including other ESCRT components
    Similarity: Belongs to the SNF7 family


    CHMP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHMP3_HUMAN, Q9Y3E7
    Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
    involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs
    contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane
    of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as
    stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the
    sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the
    invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent
    membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1
    and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or
    membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to
    phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides
    tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor.
    Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast
    cells

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17711858
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ----
         
    CHMP3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHMP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHMP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHMP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHMP3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHMP3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CHMP3
    SwitchGear 3'UTR luciferase reporter plasmidCHMP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHMP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHMP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHMP3
    Sirion Biotech Customized adenovirus for overexpression of CHMP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CHMP3 (see all 15)
    OriGene ORF clones in mouse, rat for CHMP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CHMP3
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP3
    Sirion Biotech Customized lentivirus for stable overexpression of CHMP3 
                         Customized lentivirus expression plasmids for stable overexpression of CHMP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHMP3
    Search LifeMap BioReagents cell lines for CHMP3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHMP3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    2Endosomal Sorting Complex Required For Transport (ESCRT)
    Endosomal Sorting Complex Required For Transport (ESCRT)0.71
    Budding and maturation of HIV virion0.71
    3Membrane Trafficking
    Membrane Trafficking0.32
    4Internalization of ErbB1
    Internalization of ErbB1
    5Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CHMP3
        Internalization of ErbB1

    5/7        Reactome Pathways for CHMP3 (see all 7)
        HIV Life Cycle
    HIV Infection
    Late Phase of HIV Life Cycle
    Membrane Trafficking
    Budding and maturation of HIV virion


    1         Kegg Pathway  (Kegg details for CHMP3):
        Endocytosis


    CHMP3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHMP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for CHMP3 (Q9Y3E71, 2, 3 ENSP000002638564) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD5Q997172, 3MINT-61837 I2D: score=3 
    STAMBPO956301, 3, ENSP000003447424EBI-2118119,EBI-396676 I2D: score=8 STRING: ENSP00000344742
    USP54Q70EL12, 3, ENSP000003452164MINT-6947307 I2D: score=1 STRING: ENSP00000345216
    USP8P408182, 3, ENSP000003022394MINT-6946860 I2D: score=1 STRING: ENSP00000302239
    SMAD1Q157972, 3, ENSP000003057694MINT-62005 I2D: score=3 STRING: ENSP00000305769
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis ----
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0008333endosome to lysosome transport ----
    GO:0015031protein transport IEA--

    CHMP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHMP3

    Search CenterWatch for drugs/clinical trials and news about CHMP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHMP3 gene (3 alternative transcripts): 
    NM_001005753.2  NM_001193517.1  NM_016079.3  

    Unigene Cluster for CHMP3:

    Charged multivesicular body protein 3
    Hs.591582  [show with all ESTs]
    Unigene Representative Sequence: NM_001198954
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263856(uc002srj.3 uc002srk.3 uc021vkf.1 uc002srl.3 uc010ytl.2)
    ENST00000409727 ENST00000409225 ENST00000393773 ENST00000409810 ENST00000494623
    ENST00000486404 ENST00000466032 ENST00000485465 ENST00000439940
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHMP3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CHMP3
    SwitchGear 3'UTR luciferase reporter plasmidCHMP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHMP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHMP3
    Clone
    Products:
         
    OriGene clones in human, mouse for CHMP3 (see all 15)
    OriGene ORF clones in mouse, rat for CHMP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for CHMP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHMP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP3
    Sirion Biotech Customized lentivirus for stable overexpression of CHMP3 
                         Customized lentivirus expression plasmids for stable overexpression of CHMP3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHMP3
    OriGene qSTAR qPCR primer pairs in human, mouse for CHMP3
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat CHMP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHMP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHMP3

    Additional mRNA sequence: 

    AF151907.1 AF219226.1 AK025046.1 AK025260.1 AK095433.1 AK129502.1 AK290725.1 AK312353.1 
    AK315835.1 AY364249.1 BC004419.1 NR_036454.1 

    20 DOTS entries:

    DT.95166344  DT.454052  DT.120975343  DT.91984256  DT.100819407  DT.86839673  DT.95166342  DT.100819409 
    DT.100833045  DT.92446248  DT.99936247  DT.97860951  DT.100044197  DT.100819412  DT.120975296  DT.120975310 
    DT.120975321  DT.95166338  DT.114628  DT.97805997 

    24/686 AceView cDNA sequences (see all 686):

    BQ072163 BQ876326 BM764875 AI653587 AI344456 AA425020 AI302234 AI914828 
    AA583169 BE465391 BQ425616 BU179858 AI744106 AA976409 BM463814 CA749056 
    BF589899 AI978665 AI827266 BM671610 AI401606 BM698527 CR606230 BG820376 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CHMP3 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b · 11c · 11d
    SP1:                    -     -     -     -                 -     -     -                       -                                   -                           
    SP2:                    -     -     -     -                 -     -     -                 -     -     -                             -                           
    SP3:                                                        -     -     -                       -                                                               
    SP4:                    -     -     -     -     -     -     -     -     -                       -                                   -                           
    SP5:                                                              -     -                       -                                                               


    ECgene alternative splicing isoforms for CHMP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHMP3 expression in normal human tissues (normalized intensities)      CHMP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTAATTC
    CHMP3 Expression
    About this image


    CHMP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 6 entries
             vagina ; squamous epithelial cells   
             breast epithelium   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Breast
             breast ; glandular cells   
             breast epithelium   

    See CHMP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHMP3

    SOURCE GeneReport for Unigene cluster: Hs.591582

    UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7
    Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney
    and pancreas

        SABiosciences Custom PCR Arrays for CHMP3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHMP3
    OriGene qSTAR qPCR primer pairs in human, mouse for CHMP3
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat CHMP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHMP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHMP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHMP3 gene from 9/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chmp31 , 5 charged multivesicular body protein 31, 5 89.79(n)1
    96.85(a)1
      6 (32.17 cM)5
    667001  NM_025783.31  NP_080059.21 
     715437975 
    chicken
    (Gallus gallus)
    Aves VPS241 vacuolar protein sorting 24 homolog (S. cerevisiae) 81.8(n)
    92.2(a)
      422918  XM_420858.3  XP_420858.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    68(a)
    1 → many
    6(60553158-60564677)
    zebrafish
    (Danio rerio)
    Actinopterygii wufb47g012 Transcribed sequence with moderate similarity to protein more 76.89(n)    CD285244.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vps241 Charged multivesicular body protein 3 61.6(n)
    62.21(a)
      40542  NM_141194.2  NP_649451.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T27F7.11 Protein T27F7.1 59.26(n)
    59.42(a)
      173863  NM_062518.4  NP_494919.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS24(YKL041W)4
    VPS241
    One of four subunits of the endosomal sorting complex more4
    Vps24p1
    43.6(n)1
    29.38(a)1
      11(360143-360817)4
    8538251, 4  NP_012883.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS24.21 charged multivesicular body protein 3 50.71(n)
    42.02(a)
      823635  NM_114369.1  NP_190086.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01084001 hypothetical protein 52.31(n)
    49.23(a)
      4331337  NM_001055235.2  NP_001048700.2 


    ENSEMBL Gene Tree for CHMP3 (if available)
    TreeFam Gene Tree for CHMP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHMP3 gene
    RNF103-CHMP32  
    2 SIMAP similar genes for CHMP3 using alignment to 1 protein entry:     CHMP3_HUMAN:
    CHMP2B    CHMP2A

    CHMP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CHMP3
    PGOHUM00000239515


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for CHMP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610052    OMIM disorders: --

    7 diseases for CHMP3:    About MalaCards
    non-small cell lung carcinoma    conjunctivitis    herpes simplex    pancreatic cancer
    pancreatitis    prostate cancer    prostatitis


    CHMP3 for disorders           About GeneDecksing


    Export disorders for CHMP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHMP3 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with CHMP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. (PubMed id 11549700)1, 2, 3 Wilson E.M.... Rosenfeld R.G. (2001)
    2. Structural basis for ESCRT-III protein autoinhibition . (PubMed id 19525971)1, 2, 9 Bajorek M....Sundquist W.I. (2009)
    3. Helical structures of ESCRT-III are disassembled by VPS4. (PubMed id 18687924)1, 2, 9 Lata S....Weissenhorn W. (2008)
    4. Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. (PubMed id 15632132)1, 2, 9 Lin Y.... Hanson P.I. (2005)
    5. Structural basis for Escrt-III Chmp3 recruitment of Amsh. (PubMed id 21827950)1, 2 Solomons J.... Weissenhorn W. (2011)
    6. Structural basis for autoinhibition of ESCRT-III CHMP3. (PubMed id 18395747)1, 2 Lata S.... Weissenhorn W. (2008)
    7. Characterization of a novel alternatively spliced human transcript encoding an N-terminally truncated Vps24 protein that suppresses the effects of Bax in an ESCRT independent manner in yeast. (PubMed id 17331679)1, 2 Khoury C.M....Greenwood M.T. (2007)
    8. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. (PubMed id 17261583)1, 2 Ma Y.M.... Kirchhausen T. (2007)
    9. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1, 2 Tsang H.T.H....Sanderson C.M. (2006)
    10. Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding. (PubMed id 17146056)1, 2 Zamborlini A....Gottlinger H. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51652 HGNC: 29865 AceView: RNF103andVPS24 Ensembl:ENSG00000115561 euGenes: HUgn51652
    ECgene: CHMP3 Kegg: 51652 H-InvDB: CHMP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHMP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHMP3 gene:
    Search GeneIP for patents involving CHMP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHMP3  
     OriGene qPCR primer pairs and template standards for CHMP3   OriGene Protein Over-expression Lysate for CHMP3  
     OriGene MassSpec something-or-other for CHMP3   OriGene clones in human, mouse for CHMP3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHMP3   OriGene Purified Protein for CHMP3  
     OriGene ORF clones in mouse, rat for CHMP3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHMP3   OriGene Custom Protein Services for CHMP3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHMP3
     QIAGEN SeqTarget long-range PCR primers for resequencing CHMP3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHMP3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHMP3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHMP3
     GenScript Custom Purified and Recombinant Proteins Services for CHMP3 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for CHMP3
     GenScript Custom Assay Services for CHMP3 GenScript Custom Superior Antibodies Services for CHMP3
     GenScript Custom overexpressing Cell Line Services for CHMP3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for CHMP3
     Search Chromatin IP Primers for CHMP3
     Search RT2 qPCR Primer Assays in human, mouse, rat CHMP3
     Search GNC Networks for CHMP3
     SABiosciences Custom PCR Arrays for CHMP3
     Search Tocris compounds for CHMP3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CHMP3 antibodies
     CHMP3 proteins
     CHMP3 lysates
     Antibodies for CHMP3
     See all of Abcam's Antibodies, Kits and Proteins for CHMP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for CHMP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP3
     SwitchGear 3'UTR luciferase reporter plasmids for CHMP3
     SwitchGear Promoter luciferase reporter plasmids for CHMP3
     Search ThermoFisher Antibodies for CHMP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CHMP3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHMP3
    Customized:
     lentivirus for stable overexpression of CHMP3
     lentivirus expression plasmids for stable overexpression of CHMP3
     adenovirus for overexpression of CHMP3
     LSBio Antibodies in human, mouse, rat for CHMP3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHMP3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4