CHMP3 Gene
protein-coding GIFtS: 52
GCID: GC02M086730
|
|
charged multivesicular body protein 3(Previous names: vacuolar protein sorting 24 (yeast), vacuolar protein sorting...)
(Previous symbol: VPS24)
| |
Aliases
for CHMP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Charged Multivesicular Body Protein 31 2 | | Vacuolar Protein Sorting 24 (Yeast)1 | | NEDF1 2 3 5 | | Vacuolar Protein Sorting 24 Homolog (S. Cerevisiae)1 | | VPS241 2 3 5 | | 25.1 Protein2 | | Chromatin-Modifying Protein 32 3 | | CHMP Family, Member 32 | | Neuroendocrine Differentiation Factor2 3 | | Vacuolar Protein Sorting 24 Homolog2 | | Vacuolar Protein Sorting-Associated Protein 242 3 | | CGI1493 | | CGI-1491 | | HVps241 |
Export aliases for CHMP3 gene to outside databases |
Summaries
for CHMP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHMP3:
This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB)pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III proteincomplex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. Thisprotein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicingresults in multiple transcript variants. Read-through transcription also exists between this gene and the upstreamring finger protein 103 (RNF103) gene. (provided by RefSeq, Nov 2010)
UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which isinvolved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs containintraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of theendosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growthfactor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV isreleased. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminalstages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins arebelieved to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction withthe AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 inpreference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomalsorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygenspecies when expressed in yeast cells
Gene Wiki entry for CHMP3 (VPS24)
|
Genomic Views
for CHMP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CHMP3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHMP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p11.2 Ensembl cytogenetic band: 2p11.2 HGNC cytogenetic band: 2p11.2CHMP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M086730: view genomic region
(about GC identifiers)
Start:
|
86,730,553 bp from pter |
End:
|
86,948,245 bp from pter |
Size:
|
217,693 bases |
Orientation:
|
minus strand |
|
Proteins
for CHMP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7 (See
protein sequence)Recommended Name: Charged multivesicular body protein 3 Size: 222 amino acids; 25073 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-IIIcomponents are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Severalassembly forms of ESCRT-III may exist that interact and act sequentally. Forms a metastable monomer in solution; itscore structure (without part of the putative autoinhibitory C-terminal acidic region) oligomerizes into a flat latticevia two different dimerization interfaces. In vitro, heteromerizes with CHMP2A (but not CHMP4) to form helical tubularstructures that expose membrane-interacting sites on the outside whereas VPS4B can associate on the inside of thetubule. May interact with IGFBP7; the relevance of such interaction however remains unclear. Interacts with CHMP2A.Interacts with CHMP4A; the interaction requires the release of CHMP4A autoinhibition. Interacts with VPS4A. Interactswith STAMBP; the interaction appears to relieve the autoinhibition of CHMP3
Subcellular location: Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane (Probable).Note=Localizes to the midbody of dividing cells
Miscellaneous: Its overexpression strongly inhibits HIV-1 release
4 PDB 3D structures from  and Proteopedia  for CHMP3:2GD5 (3D)
2XZE (3D)
3FRT (3D)
3FRV (3D)
Secondary accessions: A8K3W0 B4DG34 B8ZZM0 B8ZZX5 Q3ZTS9 Q53S71 Q53SU5 Q9NZ51Alternative splicing: 4 isoforms: Q9Y3E7-1 Q9Y3E7-2 Q9Y3E7-3 Q9Y3E7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CHMP3: NX_Q9Y3E7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3E7
CHMP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001005753.1 NP_001180446.1 NP_057163.1
ENSEMBL proteins: ENSP00000263856 ENSP00000387045 ENSP00000386590 ENSP00000405575 Reactome Protein details: Q9Y3E7
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CHMP3 for ontologies About GeneDecksing
CHMP3 Antibody Products:
Assay Products for CHMP3: |
Protein
Domains /
Families
for CHMP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHMP3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y3E7ProtoNet protein and cluster: Q9Y3E7 1 Blocks protein family: IPB005024 Eukaryotic protein of unknown function DUF279
UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble andinactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, whichenables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners,probably including other ESCRT componentsSimilarity: Belongs to the SNF7 family |
Function
for CHMP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which isinvolved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs containintraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of theendosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growthfactor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV isreleased. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminalstages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins arebelieved to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction withthe AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 inpreference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomalsorting/trafficking of EGF receptor. Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygenspecies when expressed in yeast cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for CHMP3 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHMP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CHMP3 for ontologies About GeneDecksing
|
Pathways & Interactions
for CHMP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Membrane Trafficking | | | 2 | Internalization of ErbB1 | | | 3 | Endocytosis | | | 4 | Signal Transduction | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for CHMP3
2 
Reactome Pathways for CHMP3
1 
Kegg Pathway (Kegg details for CHMP3):
CHMP3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHMP3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/49 Interacting proteins for CHMP3 (Q9Y3E71, 2, 3 ENSP000002638564) via UniProtKB, MINT, STRING, and/or I2D (see all 49)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SMAD5 | Q997172, 3 | MINT-61837 I2D:
score=3 | | STAMBP | O956301, 3, ENSP000003447424 | EBI-2563192,EBI-396676 I2D:
score=8 STRING: ENSP00000344742 | | USP54 | Q70EL12, 3, ENSP000003452164 | MINT-6947307 I2D:
score=1 STRING: ENSP00000345216 | | USP8 | P408182, 3, ENSP000003022394 | MINT-6946860 I2D:
score=1 STRING: ENSP00000302239 | | SMAD1 | Q157972, 3, ENSP000003057694 | MINT-62005 I2D:
score=3 STRING: ENSP00000305769 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
CHMP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHMP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CHMP3
Search CenterWatch for drugs/clinical trials and news about CHMP3
|
Transcripts
for CHMP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHMP3 gene (3 alternative transcripts): NM_001005753.2 NM_001193517.1 NM_016079.3 Unigene Cluster for CHMP3: Charged multivesicular body protein 3 Hs.591582 [show with all ESTs]Unigene Representative Sequence: NM_00119895410 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263856(uc002srj.3 uc002srk.3 uc021vkf.1 uc002srl.3 uc010ytl.2)
ENST00000409727 ENST00000409225 ENST00000393773 ENST00000409810 ENST00000494623
ENST00000486404 ENST00000466032 ENST00000485465 ENST00000439940
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP3 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for CHMP3 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHMP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP3 |
Additional cDNA sequence: AF151907.1 AF219226.1 AK025046.1 AK025260.1 AK095433.1 AK129502.1 AK290725.1 AK312353.1 AK315835.1 AY364249.1 BC004419.1 NR_036454.1 20 DOTS entries: DT.95166344 DT.454052 DT.120975343 DT.91984256 DT.100819407 DT.86839673 DT.95166342 DT.100819409 DT.100833045 DT.92446248 DT.99936247 DT.97860951 DT.100044197 DT.100819412 DT.120975296 DT.120975310 DT.120975321 DT.95166338 DT.114628 DT.97805997 24/686 AceView cDNA sequences (see all 686): CA426800 NM_005667 AL554722 AI681045 BG286374 AI380302 AI436107 AA356689 AI302234 BQ948966 AA425020 CD678639 AI754094 CD106343 AI393752 BQ427968 BP373470 AI497768 AV650564 BG391326 AA658165 AA961668 CA749056 BM710188
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for CHMP3 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | | | | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CHMP3
|
Expression
for CHMP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHMP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTTAATTC
About this image
See CHMP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHMP3
SOURCE GeneReport for Unigene cluster: Hs.591582
UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney andpancreas
SABiosciences Custom PCR Arrays for CHMP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHMP3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CHMP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHMP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHMP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP3 |
Orthologs
for CHMP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CHMP3 gene from 7/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
VPS241 |
vacuolar protein sorting 24 homolog (S. cerevisiae) |
81.8(n)
92.2(a) |
|
422918 XM_420858.3 XP_420858.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb47g012 |
Transcribed sequence with moderate similarity to protein more |
76.89(n) |
|
CD285244.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
vps241 |
Charged multivesicular body protein 3 |
61.6(n)
62.21(a) |
|
40542 NM_141194.2 NP_649451.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
T27F7.11 |
Protein T27F7.1 |
59.26(n)
59.42(a) |
|
173863 NM_062518.4 NP_494919.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
VPS24(YKL041W)4
VPS241 |
One of four subunits of the endosomal sorting complex more4
Vps24p1 |
43.6(n)1
29.38(a)1 |
|
11(360143-360817)4
8538251, 4 NP_012883.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
VPS24.21 |
charged multivesicular body protein 3 |
50.71(n)
42.02(a) |
|
823635 NM_114369.1 NP_190086.1 |
rice
(Oryza sativa) |
Liliopsida |
Os03g01084001 |
hypothetical protein |
52.31(n)
49.23(a) |
|
4331337 NM_001055235.2 NP_001048700.2 |
ENSEMBL Gene Tree for CHMP3 (if available)
TreeFam Gene Tree for CHMP3 (if available) |
Paralogs
for CHMP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHMP3 gene
2 SIMAP similar genes for CHMP3 using alignment to 1 protein entry: CHMP3_HUMAN:CHMP2B CHMP2A
CHMP3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CHMP3
PGOHUM00000239515
|
Genomic Variants
for CHMP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHMP3 (86730553 - 86948245 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHMP3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHMP3 |
|
Disorders
/ Diseases
for CHMP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHMP3 for disorders About GeneDecksing
OMIM gene information: 610052
OMIM disorders: --
11  diseases for CHMP3: About MalaCardsnon-small cell lung carcinoma herpes simplex lung carcinoma conjunctivitis
prostate cancer carcinoma prostatitis immunodeficiency
malaria pancreatic cancer pancreatitis
Export disorders for CHMP3 gene to outside databases
|
Publications
for CHMP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHMP3 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with CHMP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. (PubMed id 11549700)1, 2, 3 Wilson E.M.... Rosenfeld R.G. (2001)
- Structural basis for ESCRT-III protein autoinhibition . (PubMed id 19525971)1, 2, 9 Bajorek M....Sundquist W.I. (2009)
- Helical structures of ESCRT-III are disassembled by VPS4. (PubMed id 18687924)1, 2, 9 Lata S....Weissenhorn W. (2008)
- Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. (PubMed id 15632132)1, 2, 9 Lin Y.... Hanson P.I. (2005)
- Structural basis for Escrt-III Chmp3 recruitment of Amsh. (PubMed id 21827950)1, 2 Solomons J.... Weissenhorn W. (2011)
- Structural basis for autoinhibition of ESCRT-III CHMP3. (PubMed id 18395747)1, 2 Lata S.... Weissenhorn W. (2008)
- Characterization of a novel alternatively spliced human transcript encoding an N-terminally truncated Vps24 protein that suppresses the effects of Bax in an ESCRT independent manner in yeast. (PubMed id 17331679)1, 2 Khoury C.M....Greenwood M.T. (2007)
- Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. (PubMed id 17261583)1, 2 Ma Y.M.... Kirchhausen T. (2007)
- A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1, 2 Tsang H.T.H....Sanderson C.M. (2006)
- Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding. (PubMed id 17146056)1, 2 Zamborlini A....Gottlinger H. (2006)
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External Searches for CHMP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CHMP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CHMP3 gene
(According to HUGE)
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Specialized Databases showing CHMP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CHMP3 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CHMP3 gene:
Search GeneIP for patents involving CHMP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CHMP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHMP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHMP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHMP3 | | | OriGene Protein Over-expression Lysate for CHMP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHMP3 | | OriGene 3'-UTR Clone for CHMP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CHMP3 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHMP3 | | OriGene Custom Protein Services for CHMP3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHMP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHMP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHMP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHMP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHMP3 |
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| | | | Search Tocris compounds for CHMP3 |
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 | | | CHMP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP3 |
|  |  |  | | | | Search ThermoFisher Antibodies for CHMP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP3 |
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