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CHMP3 Gene

protein-coding   GIFtS: 50
GCID: GC02M086730

Charged Multivesicular Body Protein 3

(Previous names: vacuolar protein sorting 24 (yeast), vacuolar protein sorting...)
(Previous symbol: VPS24)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Charged Multivesicular Body Protein 31 2     Vacuolar Protein Sorting 24 Homolog (S. Cerevisiae)1
VPS241 2 3 5     25.1 Protein2
NEDF2 3 5     CHMP Family, Member 32
Chromatin-Modifying Protein 32 3     Vacuolar Protein Sorting 24 Homolog2
Neuroendocrine Differentiation Factor2 3     CGI1493
Vacuolar Protein Sorting-Associated Protein 242 3     hVps243
Vacuolar Protein Sorting 24 (Yeast)1     

External Ids:    HGNC: 298651   Entrez Gene: 516522   Ensembl: ENSG000001155617   OMIM: 6100525   UniProtKB: Q9Y3E73   

Export aliases for CHMP3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHMP3 Gene:
This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body
(MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the
ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein
sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein
superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists
between this gene and the upstream ring finger protein 103 (RNF103) gene. (provided by RefSeq, Nov 2010)

GeneCards Summary for CHMP3 Gene:
CHMP3 (charged multivesicular body protein 3) is a protein-coding gene. Diseases associated with CHMP3 include conjunctivitis, and herpes simplex. An important paralog of this gene is RNF103-CHMP3.

UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs
contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane
of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as
stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the
sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the
invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent
membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1
and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or
membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to
phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides
tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor.
Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast
cells

Gene Wiki entry for CHMP3 (VPS24) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_022184.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CHMP3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHMP3 promoter sequence
   Search Chromatin IP Primers for CHMP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHMP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p11.2   Ensembl cytogenetic band:  2p11.2   HGNC cytogenetic band: 2p11.2

CHMP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M086730:  view genomic region     (about GC identifiers)

Start:
86,730,553 bp from pter      End:
86,948,245 bp from pter
Size:
217,693 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7 (See protein sequence)
Recommended Name: Charged multivesicular body protein 3  
Size: 222 amino acids; 25073 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III).
ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome.
Several assembly forms of ESCRT-III may exist that interact and act sequentally. Forms a metastable monomer in
solution; its core structure (without part of the putative autoinhibitory C-terminal acidic region) oligomerizes
into a flat lattice via two different dimerization interfaces. In vitro, heteromerizes with CHMP2A (but not
CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can
associate on the inside of the tubule. May interact with IGFBP7; the relevance of such interaction however
remains unclear. Interacts with CHMP2A. Interacts with CHMP4A; the interaction requires the release of CHMP4A
autoinhibition. Interacts with VPS4A. Interacts with STAMBP; the interaction appears to relieve the
autoinhibition of CHMP3. Interacts with VTA1
Miscellaneous: Its overexpression strongly inhibits HIV-1 release
4 PDB 3D structures from and Proteopedia for CHMP3:
2GD5 (3D)        2XZE (3D)        3FRT (3D)        3FRV (3D)    
Secondary accessions: A8K3W0 B4DG34 B8ZZM0 B8ZZX5 Q3ZTS9 Q53S71 Q53SU5 Q9NZ51
Alternative splicing: 4 isoforms:  Q9Y3E7-1   Q9Y3E7-2   Q9Y3E7-3   Q9Y3E7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHMP3: NX_Q9Y3E7

Explore proteomics data for CHMP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys179
  • Modification sites at PhosphoSitePlus

  • See CHMP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001005753.1  NP_001180446.1  NP_057163.1  

    ENSEMBL proteins: 
     ENSP00000263856   ENSP00000387045   ENSP00000386590   ENSP00000405575  
    Reactome Protein details: Q9Y3E7

    CHMP3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHMP: Charged multivesicular body proteins

    1 InterPro protein domain:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry Q9Y3E7

    ProtoNet protein and cluster: Q9Y3E7

    1 Blocks protein domain: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7
    Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and
    inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation,
    which enables membrane binding and oligomerization, is achieved by interaction with other cellular binding
    partners, probably including other ESCRT components
    Similarity: Belongs to the SNF7 family


    CHMP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHMP3_HUMAN, Q9Y3E7
    Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
    involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs
    contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane
    of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as
    stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the
    sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the
    invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent
    membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1
    and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or
    membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to
    phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides
    tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor.
    Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species when expressed in yeast
    cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17711858
         
    CHMP3 for ontologies           About GeneDecksing


    Animal Models:
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    Block miRNA regulation of human, mouse, rat CHMP3 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHMP3_HUMAN, Q9Y3E7: Cytoplasm, cytosol. Membrane; Lipid-anchor. Endosome. Late endosome membrane (Probable).
    Note=Localizes to the midbody of dividing cells

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0031902late endosome membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    CHMP3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHMP3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    2Budding and maturation of HIV virion
    Budding and maturation of HIV virion0.64
    Endosomal Sorting Complex Required For Transport (ESCRT)0.64
    3Clathrin derived vesicle budding
    Membrane Trafficking0.32
    4Internalization of ErbB1
    Internalization of ErbB1
    5Endocytosis
    Endocytosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CHMP3
        Internalization of ErbB1

    2 Reactome Pathways for CHMP3
        Budding and maturation of HIV virion
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1 Kegg Pathway  (Kegg details for CHMP3):
        Endocytosis


    CHMP3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHMP3
    Interactions:

        Search GeneGlobe Interaction Network for CHMP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHMP3 (Q9Y3E71, 2, 3 ENSP000002638564) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD5Q997172, 3MINT-61837 I2D: score=3 
    STAMBPO956301, 3, ENSP000003447424EBI-2118119,EBI-396676 I2D: score=8 STRING: ENSP00000344742
    USP54Q70EL12, 3, ENSP000003452164MINT-6947307 I2D: score=1 STRING: ENSP00000345216
    USP8P408182, 3, ENSP000003022394MINT-6946860 I2D: score=1 STRING: ENSP00000302239
    SMAD1Q157972, 3, ENSP000003057694MINT-62005 I2D: score=3 STRING: ENSP00000305769
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007049cell cycle IEA--
    GO:0015031protein transport IEA--
    GO:0016032viral process TAS--
    GO:0016197endosomal transport TAS--

    CHMP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for CHMP3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHMP3 gene (3 alternative transcripts): 
    NM_001005753.2  NM_001193517.1  NM_016079.3  

    Unigene Cluster for CHMP3:

    Charged multivesicular body protein 3
    Hs.591582  [show with all ESTs]
    Unigene Representative Sequence: NM_001198954
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263856(uc002srj.3 uc002srk.3 uc021vkf.1 uc002srl.3 uc010ytl.2)
    ENST00000409727 ENST00000409225 ENST00000393773 ENST00000409810 ENST00000494623
    ENST00000486404 ENST00000466032 ENST00000485465 ENST00000439940
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    Additional mRNA sequence: 

    AF151907.1 AF219226.1 AK025046.1 AK025260.1 AK095433.1 AK129502.1 AK290725.1 AK312353.1 
    AK315835.1 AY364249.1 BC004419.1 NR_036454.1 

    20 DOTS entries:

    DT.95166344  DT.454052  DT.120975343  DT.91984256  DT.100819407  DT.86839673  DT.95166342  DT.100819409 
    DT.100833045  DT.92446248  DT.99936247  DT.97860951  DT.100044197  DT.100819412  DT.120975296  DT.120975310 
    DT.120975321  DT.95166338  DT.114628  DT.97805997 

    Selected AceView cDNA sequences (see all 686):

    BM988996 AL554722 H88341 AA658165 H87949 BM463814 AI681045 BI335898 
    AI302234 AA195697 AI279015 BI438736 AI765285 BF432290 AA749016 AA861550 
    CA395653 CA749056 BP345021 AI521519 BQ948966 AA935264 AA425020 AI276244 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHMP3 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b · 11c · 11d
    SP1:                    -     -     -     -                 -     -     -                       -                                   -                           
    SP2:                    -     -     -     -                 -     -     -                 -     -     -                             -                           
    SP3:                                                        -     -     -                       -                                                               
    SP4:                    -     -     -     -     -     -     -     -     -                       -                                   -                           
    SP5:                                                              -     -                       -                                                               


    ECgene alternative splicing isoforms for CHMP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHMP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTTAATTC
    CHMP3 Expression
    About this image

    CHMP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHMP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591582

    UniProtKB/Swiss-Prot: CHMP3_HUMAN, Q9Y3E7
    Tissue specificity: Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney
    and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHMP3 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chmp31 , 5 charged multivesicular body protein 31, 5 89.19(n)1
    95.95(a)1
      6 (32.17 cM)5
    667001  NM_025783.31  NP_080059.21 
     715437975 
    chicken
    (Gallus gallus)
    Aves CHMP31 charged multivesicular body protein 3 81.65(n)
    91.28(a)
      422918  XM_420858.4  XP_420858.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    6(60553158-60564677)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia chmp31 charged multivesicular body protein 3 76.82(n)
    83.64(a)
      548983  NM_001016229.2  NP_001016229.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb47g012 Transcribed sequence with moderate similarity to protein more 76.89(n)    CD285244.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vps241 Charged multivesicular body protein 3 59.72(n)
    60.65(a)
      40542  NM_141194.3  NP_649451.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T27F7.11 T27F7.1 61.8(n)
    63.48(a)
      173863  NM_062518.5  NP_494919.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS24(YKL041W)4
    VPS241
    One of four subunits of the endosomal sorting complex more4
    VPS241
    44.53(n)1
    32.82(a)1
      11(360143-360817)4
    8538251, 4  NP_012883.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS24.11 VPS24.1 54.1(n)
    44.57(a)
      832359  NM_122201.1  NP_197686.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01084001 Os03g0108400 53.18(n)
    50.38(a)
      4331337  NM_001055235.2  NP_001048700.2 


    ENSEMBL Gene Tree for CHMP3 (if available)
    TreeFam Gene Tree for CHMP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for CHMP3 gene
    RNF103-CHMP32  
    2 SIMAP similar genes for CHMP3 using alignment to 1 protein entry:     CHMP3_HUMAN:
    CHMP2B    CHMP2A

    CHMP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CHMP3
    PGOHUM00000239515


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHMP3
    DNA2.0 Custom Variant and Variant Library Synthesis for CHMP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610052    OMIM disorders: --

    12 diseases for CHMP3:    
    About MalaCards
    conjunctivitis    herpes simplex    hiv-1    tonsillitis
    pancreatic cancer    pancreatitis    prostatitis    prostate cancer
    thyroiditis    malaria    cerebritis    endotheliitis


    CHMP3 for disorders           About GeneDecksing


    Export disorders for CHMP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CHMP3 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with CHMP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of IGF-binding protein-related protein 1 with a novel protein, neuroendocrine differentiation factor, results in neuroendocrine differentiation of prostate cancer cells. (PubMed id 11549700)1, 2, 3 Wilson E.M.... Rosenfeld R.G. (J. Clin. Endocrinol. Metab. 2001)
    2. Structural basis for ESCRT-III protein autoinhibition. (PubMed id 19525971)1, 2, 9 Bajorek M.... Sundquist W.I. (Nat. Struct. Mol. Biol. 2009)
    3. Helical structures of ESCRT-III are disassembled by VPS4. (PubMed id 18687924)1, 2, 9 Lata S....Weissenhorn W. (Science 2008)
    4. Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. (PubMed id 15632132)1, 2, 9 Lin Y.... Hanson P.I. (J. Biol. Chem. 2005)
    5. Structural basis for Escrt-III Chmp3 recruitment of Amsh. (PubMed id 21827950)1, 2 Solomons J.... Weissenhorn W. (Structure 2011)
    6. Mechanism of inhibition of retrovirus release from cells by interferon-induced gene ISG15. (PubMed id 21543490)1, 2 Kuang Z....Leis J. (J. Virol. 2011)
    7. Structural basis for autoinhibition of ESCRT-III CHMP3. (PubMed id 18395747)1, 2 Lata S.... Weissenhorn W. (J. Mol. Biol. 2008)
    8. Characterization of a novel alternatively spliced human transcript encoding an N-terminally truncated Vps24 protein that suppresses the effects of Bax in an ESCRT independent manner in yeast. (PubMed id 17331679)1, 2 Khoury C.M.... Greenwood M.T. (Gene 2007)
    9. Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation. (PubMed id 17261583)1, 2 Ma Y.M.... Kirchhausen T. (J. Biol. Chem. 2007)
    10. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1, 2 Tsang H.T.H....Sanderson C.M. (Genomics 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51652 HGNC: 29865 AceView: RNF103andVPS24 Ensembl:ENSG00000115561 euGenes: HUgn51652
    ECgene: CHMP3 Kegg: 51652 H-InvDB: CHMP3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CHMP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CHMP3 gene:
    Search GeneIP for patents involving CHMP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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