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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHMP2A Gene

protein-coding   GIFtS: 59
GCID: GC19M059062

charged multivesicular body protein 2A

(Previous name: chromatin modifying protein 2A )
 Explore 3 diseases affiliated with
CHMP2A via our new
 Human Malady Compendium 
Biological research products
for CHMP2A
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Charged Multivesicular Body Protein 2A1 2     Putative Breast Adenocarcinoma Marker BC-22 3
CHMP21 2 3     Vacuolar Protein Sorting-Associated Protein 2-12 3
VPS21 2 5     HVps2-11
VPS2A1 2 5     Putative Breast Adenocarcinoma Marker (32kD)2
BC22 3 5     VPS2 Homolog A2
BC-21 2     Vps2-13
Chromatin Modifying Protein 2A1 2     CHMP2a3
Chromatin-Modifying Protein 2a2 3     Vps2-13

External Ids:    HGNC: 302161   Entrez Gene: 272432   Ensembl: ENSG000001307247   OMIM: 6108935   UniProtKB: O436333   

Export aliases for CHMP2A gene to outside databases

Previous GC identifers: GC19M063755 GC19M055373


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHMP2A:
CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are
components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of
surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and
cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and
regulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: CHM2A_HUMAN, O43633
Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the
endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth
factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,
-I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is
released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal
stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are
believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with
the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release

Gene Wiki entry for CHMP2A


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHMP2A gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHMP2A promoter sequence
   Search SABiosciences Chromatin IP Primers for CHMP2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

CHMP2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHMP2A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M059062:  view genomic region     (about GC identifiers)

Start:
59,062,933 bp from pter      End:
59,066,486 bp from pter
Size:
3,554 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHM2A_HUMAN, O43633 (See protein sequence)
Recommended Name: Charged multivesicular body protein 2a  
Size: 222 amino acids; 25104 Da
Subunit: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III
components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several
assembly forms of ESCRT-III may exist that interact and act sequentally. In vitro, heteromerizes with CHMP3 (but not
CHMP4) to form helical tubular structures that expose membrane-interacting sites on the outside whereas VPS4B can
associate on the inside of the tubule. Interacts with CHMP1B, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C and CHMP5.
Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with
MITD1. Interacts with VTA1; the interaction probably involves the open conformation of CHMP2A
Subcellular location: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the
midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body
Miscellaneous: Its overexpression strongly inhibits HIV-1 release
Secondary accessions: B2R4W6 Q3ZTT0

Explore the universe of human proteins at neXtProt for CHMP2A: NX_O43633

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O43633

  • CHMP2A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_055268.1  NP_940818.1  

    ENSEMBL proteins: 
     ENSP00000310440  
    Reactome Protein details: O43633
    Human Recombinant Protein Products: 
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    Uscn Proteins for CHMP2A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0031902late endosome membrane IEA--


    CHMP2A for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CHMP2A for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005024 Snf7

    Graphical View of Domain Structure for InterPro Entry O43633

    ProtoNet protein and cluster: O43633

    1 Blocks protein family: IPB005024 Eukaryotic protein of unknown function DUF279

    UniProtKB/Swiss-Prot: CHM2A_HUMAN, O43633
    Domain: The acidic C-terminus and the basic N-termminus are thought to render the protein in a closed, soluble and
    inactive conformation through an autoinhibitory intramolecular interaction. The open and active conformation, which
    enables membrane binding and oligomerization, is achieved by interaction with other cellular binding partners,
    probably including other ESCRT components
    Similarity: Belongs to the SNF7 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CHM2A_HUMAN, O43633
    Function: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is
    involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain
    intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the
    endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth
    factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,
    -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is
    released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal
    stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are
    believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with
    the AAA ATPase VPS4. Involved in HIV-1 p6- and p9-dependent virus release

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CHMP2A:
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19525971
    GO:0019904protein domain specific binding IPI17928862


    CHMP2A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for CHMP2A:
     Decreased Hepatitis C virus re  Decreased viability with cispl  Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Membrane Trafficking
    Membrane Trafficking1.00
    2Endocytosis
    Endocytosis1.00
    3Signal Transduction
    Endosomal Sorting Complex Required For Transport (ESCRT)0.14

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for CHMP2A
        Membrane Trafficking
    Endosomal Sorting Complex Required For Transport (ESCRT)


    1         Kegg Pathway  (Kegg details for CHMP2A):
        Endocytosis


    CHMP2A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHMP2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/61 Interacting proteins for CHMP2A (O436332, 3 ENSP000003104404) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP54Q70EL12, 3, ENSP000003452164MINT-6947279 I2D: score=1 STRING: ENSP00000345216
    USP8P408182, 3, ENSP000003022394MINT-6946830 I2D: score=1 STRING: ENSP00000302239
    CHMP4AQ9BY433, ENSP000003242054I2D: score=4 STRING: ENSP00000324205
    EIF2B5Q131443, ENSP000002737834I2D: score=1 STRING: ENSP00000273783
    MITD1Q8WV923, ENSP000002893594I2D: score=1 STRING: ENSP00000289359
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0016044cellular membrane organization TAS--
    GO:0016197endosomal transport TAS--


    CHMP2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHMP2A
    Search CenterWatch for drugs/clinical trials and news about CHMP2A / CHM2A 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHMP2A gene (2 alternative transcripts): 
    NM_014453.2  NM_198426.1  

    Unigene Cluster for CHMP2A:

    Charged multivesicular body protein 2A
    Hs.12107  [show with all ESTs]
    Unigene Representative Sequence: BM542499
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312547(uc002qti.3 uc002qtj.3 uc002qtk.3)

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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CHMP2A:
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHMP2A
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    Additional cDNA sequence: 

    AF042384.1 AK311974.1 AY364248.1 BC002502.2 BT007298.1 CR457002.1 

    15 DOTS entries:

    DT.115965  DT.121473517  DT.97845612  DT.121473599  DT.92442623  DT.121473534  DT.447840  DT.99997736 
    DT.121473615  DT.102840979  DT.86852138  DT.99953083  DT.100794836  DT.121473590  DT.121473538 

    24/286 AceView cDNA sequences (see all 286):

    NM_014453 BM705125 BC047005 CA389250 BU789464 BG170705 BQ712094 BF448087 
    AI868949 BM968237 BC002502 AI753410 AA287678 AW028829 BU789156 BU147101 
    BM853923 AI400758 CA420431 BU675029 BQ224738 BQ421018 BU844484 BU629792 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CHMP2A (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c
    SP1:                    -     -     -     -           -                             -                     
    SP2:                          -     -     -           -                             -                     
    SP3:                    -     -     -     -           -                                                   
    SP4:                                                  -                             -                     
    SP5:                          -     -     -           -                                                   


    ECgene alternative splicing isoforms for CHMP2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHMP2A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGTGATGAGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CHMP2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHMP2A

    SOURCE GeneReport for Unigene cluster: Hs.12107
        SABiosciences Custom PCR Arrays for CHMP2A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP2A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHMP2A gene from 10/37 species (see all 37)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chmp2a1 , 5 charged multivesicular body protein 2A1, 5 90.69(n)1
    99.55(a)1
      7 (7.73 cM)5
    689531  NM_026885.31  NP_081161.11 
     130320065 
    chicken
    (Gallus gallus)
    Aves CHMP2A6
    --
    87(a)
    1 ↔ 1
    Un(2559030-2560512)
    lizard
    (Anolis carolinensis)
    Reptilia CHMP2A6
    --
    94(a)
    1 ↔ 1
    GL343253.1(141846-146201)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA788317.12   -- 78.72(n)    CA788317.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.23612 Danio rerio mRNA similar to RIKEN cDNA 1500016L11 gene more 77.55(n)    BC045320.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vps21 CG14542-PA 71.77(n)
    75.23(a)
      43164  NM_143198.1  NP_651455.1 
    worm
    (Caenorhabditis elegans)
    Secernentea vps-21 Protein VPS-2 65.02(n)
    69.37(a)
      174908  NM_064316.3  NP_496717.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DID4(YKL002W)4
    DID41
    Class E Vps protein of the ESCRT-III complex, required more4
    Did4p1
    52.29(n)1
    47.25(a)1
      11(437778-438544)4
    8538681, 4  NP_012924.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons VPS2.11 vacuolar protein sorting-associated protein 2-1 60.43(n)
    58.45(a)
      815211  NM_126650.3  NP_565336.1 
    rice
    (Oryza sativa)
    Liliopsida AK071087.12   -- 74.6(n)    AK071087.1 


    ENSEMBL Gene Tree for CHMP2A (if available)
    TreeFam Gene Tree for CHMP2A (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHMP2A gene
    CHMP2B2  
    3 SIMAP similar genes for CHMP2A using alignment to 4 protein entries:     CHM2A_HUMAN (see all proteins):
    CHMP2B    CHMP1B    CHMP3

    CHMP2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/72 NCBI SNPs in CHMP2A are shown (see all 72    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826930761,2
    --59062591(+) CCTTGC/TCTCTA 2 -- int10--------
    rs1878172211,2
    --59062744(+) TGATGA/GAGAAG 2 -- int10--------
    rs118812701,2
    C,F,H,--59062859(+) CTTGCC/GTTAGT 2 -- int16Minor allele frequency- G:0.01NS EA NA WA 538
    rs1913479761,2
    C,--59063008(+) GTGGCA/GGGGGC 2 -- ut310--------
    rs769480001,2
    C,--59063099(+) TTTTTC/TCCCAC 4 K E mis10--------
    rs1832663431,2
    C,--59063101(+) TTTTCC/TCACCA 4 E G mis10--------
    rs2009940471,2
    --59063121(+) CTAAGC/TGAGCC 4 S syn10--------
    rs756729651,2
    C,F,--59063157(+) AAAGTG/AGGGGT 2 -- int12Minor allele frequency- A:0.02NA EU 1385
    rs1466807031,2
    C,--59063160(+) GTGGGA/GGTTTG 2 -- int10--------
    rs1131824241,2
    C--59063272(+) ACTCAC/G/TTCGAC 2 -- spd11CSA 1

    HapMap Linkage Disequilibrium report for CHMP2A (59062933 - 59066486 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for CHMP2A
         3 CNVs: 50240 50238 50239
         1 Indel: 58896

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CHMP2A for disorders           About GeneDecksing

    OMIM gene information: 610893    OMIM disorders: --

    3 diseases for CHMP2A:    About MalaCards
    breast adenocarcinoma    adenocarcinoma    conjunctivitis


    Export disorders for CHMP2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHMP2A gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with CHMP2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. (PubMed id 11559748)1, 2, 3 Howard T.L....Hollenberg S.M. (2001)
    2. Helical structures of ESCRT-III are disassembled by VPS4. (PubMed id 18687924)1, 2, 9 Lata S....Weissenhorn W. (2008)
    3. A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1, 2 Tsang H.T.H....Sanderson C.M. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Mammalian class E Vps proteins, SBP1 and mVps2/CHMP2A, interact with and regulate the function of an AAA-ATPase SKD1/Vps4B. (PubMed id 15173323)1, 3 Fujita H....Himeno M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. (PubMed id 14519844)1, 2 Martin-Serrano J.... Bieniasz P.D. (2003)
    10. Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. (PubMed id 18385515)2, 9 Shim S.... Hanson P.I. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27243 HGNC: 30216 AceView: BC-2 Ensembl:ENSG00000130724 euGenes: HUgn27243
    ECgene: CHMP2A Kegg: 27243 H-InvDB: CHMP2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHMP2A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHMP2A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHMP2A gene:
    Search GeneIP for patents involving CHMP2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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