CHMP1B Gene
protein-coding GIFtS: 51
GCID: GC18P011851
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charged multivesicular body protein 1B(Previous name: chromatin modifying protein 1B )
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Aliases
for CHMP1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Charged Multivesicular Body Protein 1B1 2 | | Vps46-22 3 | | C18orf21 2 3 | | HVps46-21 | | CHMP1.51 2 3 | | C10orf22 5 | | Vps46B1 2 | | C18-ORF22 | | Chromatin Modifying Protein 1B1 2 | | Vacuolar Protein Sorting 46-22 | | Chromatin-Modifying Protein 1b2 3 | | CHMP1b3 | | Vacuolar Protein Sorting-Associated Protein 46-22 3 | | |
Export aliases for CHMP1B gene to outside databasesPrevious GC identifer: GC18P011842 |
Summaries
for CHMP1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHMP1B:
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins arecomponents of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation ofsurface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear andcytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation andregulation of cell cycle progression (Tsang et al., 2006 (PubMed 16730941)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: CHM1B_HUMAN, Q7LBR1Function: Probable peripherally associated component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins intoMVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limitingmembrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such asstimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequentialfunction of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membranebefore the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events,such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4Band SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release
Gene Wiki entry for CHMP1B
|
Genomic Views
for CHMP1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHMP1B gene promoter:
SRF NF-1 NF-1/L Pax-5 AML1a ATF-2 SRF (504 AA) c-Ets-1 NRF-2 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHMP1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHMP1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.21 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.21CHMP1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P011851: view genomic region
(about GC identifiers)
Start:
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11,851,389 bp from pter |
End:
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11,854,448 bp from pter |
Size:
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3,060 bases |
Orientation:
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plus strand |
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Proteins
for CHMP1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHM1B_HUMAN, Q7LBR1 (See
protein sequence)Recommended Name: Charged multivesicular body protein 1b Size: 199 amino acids; 22109 Da
Subunit: Probable peripherally associated component of the endosomal sorting required for transport complex III(ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of theendosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Interacts with CHMP1A.Interacts with VTA1; the interaction probably involves the open conformation of CHMP1B. Interacts with CHMP2A.Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with SPAST(via MIT domain); the interaction is direct. Interacts with IST1. Interacts with MITD1. Interacts with STAMBP
Subcellular location: Cytoplasm, cytosol. Endosome. Late endosome membrane; Peripheral membrane protein (Probable).Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of theFleming body
Sequence caution: Sequence=AAG01449.1; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for CHMP1B:3EAB (3D)
Secondary accessions: Q96E89 Q9HD41Explore the universe of human proteins at neXtProt for CHMP1B: NX_Q7LBR1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7LBR1
CHMP1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065145.2
ENSEMBL proteins: ENSP00000432279
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
IEA | -- | | GO:0031902 | late endosome membrane |
IEA | -- |
CHMP1B for ontologies About GeneDecksing
CHMP1B Antibody Products:
Assay Products for CHMP1B: |
Protein
Domains /
Families
for CHMP1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHMP1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7LBR1ProtoNet protein and cluster: Q7LBR1 1 Blocks protein family: IPB005024 Eukaryotic protein of unknown function DUF279
UniProtKB/Swiss-Prot: CHM1B_HUMAN, Q7LBR1Similarity: Belongs to the SNF7 family |
Function
for CHMP1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CHM1B_HUMAN, Q7LBR1Function: Probable peripherally associated component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins intoMVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limitingmembrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such asstimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequentialfunction of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membranebefore the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events,such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses).ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4Band SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP1B |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
CHMP1B for ontologies About GeneDecksing
|
Pathways & Interactions
for CHMP1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Endocytosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for CHMP1B):
CHMP1B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHMP1B
5/25 Interacting proteins for CHMP1B (Q7LBR11, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
CHMP1B for ontologies About GeneDecksing
|
Drugs & Compounds
for CHMP1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CHMP1B
Search CenterWatch for drugs/clinical trials and news about CHMP1B / CHM1B
|
Transcripts
for CHMP1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHMP1B gene: NM_020412.4 Unigene Cluster for CHMP1B: Charged multivesicular body protein 1B Hs.656244 [show with all ESTs]Unigene Representative Sequence: NM_0204122 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000526991(uc002kqe.3) ENST00000588284
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP1B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHMP1B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHMP1B (NM_020412) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHMP1B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP1B |
Additional cDNA sequence: AF281064.1 AJ227887.1 AK314068.1 BC012733.2 BC065933.1 12 DOTS entries: DT.456010 DT.100807602 DT.100710406 DT.95100288 DT.121097667 DT.95339044 DT.97823223 DT.100807591 DT.102842686 DT.121097637 DT.75163694 DT.95149101 24/217 AceView cDNA sequences (see all 217): BE877631 BU627541 CR595824 AI453160 CF131956 CA398228 AI564294 CR595721 BC065933 BQ723453 CD369914 C04706 AL548185 AA830305 BU161149 CB070114 NM_020412 BM512172 CR609374 AL546791 BM844154 AA399458 AW022811 CB130551
GeneLoc Exon Structure
|
Expression
for CHMP1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHMP1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGTGTATTC
About this image
See CHMP1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHMP1B
SOURCE GeneReport for Unigene cluster: Hs.656244
UniProtKB/Swiss-Prot: CHM1B_HUMAN, Q7LBR1Tissue specificity: Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain
SABiosciences Custom PCR Arrays for CHMP1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHMP1B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHMP1B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHMP1B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHMP1B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP1B |
Orthologs
for CHMP1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CHMP1B gene from 6/24 species (see all 24) About this table
ENSEMBL Gene Tree for CHMP1B (if available)
TreeFam Gene Tree for CHMP1B (if available) |
Paralogs
for CHMP1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHMP1B gene
- CHMP1A2
2 SIMAP similar genes for CHMP1B using alignment to 1 protein entry: CHM1B_HUMAN:CHMP1A CHMP2A
CHMP1B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CHMP1B
PGOHUM00000258429
|
Genomic Variants
for CHMP1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CHMP1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHMP1B for disorders About GeneDecksing
OMIM gene information: 606486
OMIM disorders: --
7  diseases for CHMP1B: About MalaCardsspastic paraplegia hereditary spastic paraplegia paraplegia spasticity
bipolar disorder conjunctivitis malaria
Genetic Association Database (GAD): CHMP1B
Human Genome Epidemiology (HuGE) Navigator: CHMP1B (2 documents)
Export disorders for CHMP1B gene to outside databases
|
Publications
for CHMP1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHMP1B gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with CHMP1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The hereditary spastic paraplegia protein spastin interacts with the ESCRT-III complex-associated endosomal protein CHMP1B. (PubMed id 15537668)1, 2, 3 Reid E....Sanderson C.M. (2005)
- Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B. (PubMed id 18997780)1, 2, 9 Yang D.... Hurley J.H. (2008)
- Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A. (PubMed id 16174732)1, 2, 9 Scott A....Sundquist W.I. (2005)
- Biochemical analyses of human IST1 and its function in cytokinesis. (PubMed id 19129479)1, 2 Bajorek M....Sundquist W.I. (2009)
- ESCRT-III recognition by VPS4 ATPases. (PubMed id 17928862)1, 2 Stuchell-Brereton M.D.... Sundquist W.I. (2007)
- A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. (PubMed id 16730941)1, 2 Tsang H.T.H....Sanderson C.M. (2006)
- Association analysis of CHMP1.5 genetic variation and bipolar disorder. (PubMed id 16094257)1, 4 McNabb L.D....Berrettini W.H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The protein network of HIV budding. (PubMed id 14505570)1, 2 von Schwedler U.K.... Sundquist W.I. (2003)
- Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. (PubMed id 14519844)1, 2 Martin-Serrano J.... Bieniasz P.D. (2003)
|
External Searches for CHMP1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHMP1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHMP1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHMP1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHMP1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CHMP1B gene:
Search GeneIP for patents involving CHMP1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHMP1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | | | Recombinant Protein for CHMP1B |
|
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 | | | CHMP1B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHMP1B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHMP1B |
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