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CHKB-CPT1B Gene

protein-coding   GIFtS: 20
GCID: GC22M051010

CHKB-CPT1B Readthrough (NMD Candidate)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CHKB-CPT1B Readthrough (NMD Candidate)1 2
CHKL-CPT1B2

External Ids:    HGNC: 419981   Entrez Gene: 3865932   Ensembl: ENSG000002544137   UniProtKB: H3BT564   

Export aliases for CHKB-CPT1B gene to outside databases

Previous GC identifers: GC22M049297 GC22M049355 GC22M051009


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHKB-CPT1B Gene:
The genes CHKB and CPT1B are adjacent on chromosome 22 and read-through transcripts are expressed that include
exons from both loci. The read-through transcripts are candidates for nonsense-mediated mRNA decay (NMD) and are
unlikely to express proteins. (provided by RefSeq, Jun 2009)

GeneCards Summary for CHKB-CPT1B Gene:
CHKB-CPT1B (CHKB-CPT1B readthrough (NMD candidate)) is a protein-coding gene. An important paralog of this gene is CHKA.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CHKB-CPT1B
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHKB-CPT1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.33

CHKB-CPT1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHKB-CPT1B gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M051010:  view genomic region     (about GC identifiers)

Start:
51,007,290 bp from pter      End:
51,021,428 bp from pter
Size:
14,139 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
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UniProtKB/TrEMBL: H3BT56 (See protein sequence)
Recommended Name: Protein CHKB-CPT1B  
Size: 60 amino acids; 7003 Da
Secondary accessions: J3KQX7


ENSEMBL proteins: 
 ENSP00000457031  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR011009 Kinase-like_dom

Graphical View of Domain Structure for InterPro Entry H3BT56

ProtoNet protein and cluster: H3BT56


Find genes that share domains with CHKB-CPT1B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016772transferase activity, transferring phosphorus-containing groups ----
     
Find genes that share ontologies with CHKB-CPT1B           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CHKB-CPT1B

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHKB-CPT1B
Interactions:

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000492556(uc003bmp.3 uc021wsc.1 uc003bmu.3) ENST00000453634
ENST00000452668
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CHKB-CPT1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CHKB-CPT1B Expression
About this image

CHKB-CPT1B Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for CHKB-CPT1B gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia BC0906275 cDNA sequence BC090627   --   15 (44.89 cM) 89416405 
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein

1 → many
AAWZ02039146(163-9342)
zebrafish
(Danio rerio)
Actinopterygii chkb6
choline kinase beta
8(a)
1 → many
18(7784768-7803549) ENSDARG00000063167
fruit fly
(Drosophila melanogaster)
Insecta CG22016
--
3(a)
1 → many
2L(21614232-21623627)
worm
(Caenorhabditis elegans)
Secernentea cka-26
ckb-46
(see all 6)
Protein CKB-4 (ckb-4) mRNA, complete cds
(see all 6)
6(a)
4(a)
(see all 6)
many ↔ many
many ↔ many
(see all 6)
X(4286737-4291490) WBGene00000510
V(2106398-2109387) WBGene00000514
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EKI16
CKI16
Ethanolamine kinase, primarily responsible for pho...
Choline kinase, catalyzing the first step in phosp...
2(a)
2(a)
many ↔ many
many ↔ many
IV(751631-753235) YDR147W
XII(408445-410193) YLR133W


ENSEMBL Gene Tree for CHKB-CPT1B (if available)
TreeFam Gene Tree for CHKB-CPT1B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CHKB-CPT1B gene
CHKA2  CHKB2  ETNK12  ETNK22  
1 SIMAP similar gene for CHKB-CPT1B using alignment to 1 protein entry:     H3BT56_HUMAN:
ETNK2

Find genes that share paralogs with CHKB-CPT1B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) Selected variations for CHKB-CPT1B (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
nsv914559CNV Loss21882294
nsv915495CNV Loss21882294
nsv914561CNV Loss21882294
dgv5062n71CNV Loss21882294
dgv5068n71CNV Loss21882294
esv33185CNV Loss17666407
nsv914525CNV Loss21882294
nsv914543CNV Loss21882294
nsv834239CNV Loss17160897
dgv5066n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CHKB-CPT1B gene integrated from 10 sources:
(articles sorted by number of sources associating them with CHKB-CPT1B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  2. Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. (PubMed id 18820697)1 Miyagawa T....Tokunaga K. (Nat. Genet. 2008)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  4. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1 Hirosawa M.... Ohara O. (DNA Res. 2001)
  5. Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I. (PubMed id 10918069)1 Yamazaki N.... Terada H. (J. Biol. Chem. 2000)
  6. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PubMed id 10493829)1 Loftus B.J.... Adams M.D. (Genomics 1999)
  7. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 386593 HGNC: 41998 Ensembl:ENSG00000254413 euGenes: HUgn386593 ECgene: CHKB-CPT1B
H-InvDB: CHKB-CPT1B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CHKB-CPT1B gene:
Search GeneIP for patents involving CHKB-CPT1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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