Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

CHKB Gene

protein-coding GIFtS: 61
GCID: GC22M051017

Choline Kinase Beta

(Previous name: choline kinase-like)
(Previous symbol: CHKL)

See CHKB-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Choline Kinase Beta¹ ² ³		EK² ³
CHKL¹ ² ³ ⁵		MDCMC² ⁵
CKEKB² ³ ⁵		Choline Kinase-Like¹
EKB² ³ ⁵		Choline/Ethanolamine Kinase²
Choline Kinase-Like Protein² ³		EC 2.7.1.32³
Ethanolamine Kinase Beta² ³		EC 2.7.1.82³
CHETK² ³		Choline/Ethanolamine Kinase Beta³
CK² ³		Ethanolamine Kinase³
CKB² ³

External Ids:	HGNC: 1938¹	Entrez Gene: 1120²	Ensembl: ENSG00000100288⁷	OMIM: 612395⁵	UniProtKB: Q9Y259³

Export aliases for CHKB gene to outside databases

Previous GC identifers: GC22M049149 GC22M049298 GC22M049307 GC22M049364 GC22M051007 GC22M033908

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CHKB Gene:

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to

phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of

phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources

and their recombinant gene products have been shown to have EK activity also, indicating that both activities

reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine

kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus

that include exons from the downstream CPT1B locus. (provided by RefSeq, Jun 2009)

GeneCards Summary for CHKB Gene:

CHKB (choline kinase beta) is a protein-coding gene. Diseases associated with CHKB include spermatic cord torsion, and japanese spotted fever. GO annotations related to this gene include ethanolamine kinase activity and choline kinase activity. An important paralog of this gene is CHKA.

UniProtKB/Swiss-Prot: CHKB_HUMAN, Q9Y259

Function: Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine

biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with

ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis

Gene Wiki entry for CHKB Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence at NCBI GenBank:

NC_000022.10 NC_018933.2 NT_011526.8

Regulatory elements:

Regulatory transcription factor binding sites in the CHKB gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHKB promoter sequence

Search Chromatin IP Primers for CHKB

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHKB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.33 Ensembl cytogenetic band: 22q13.33 HGNC cytogenetic band: 22q13.33

CHKB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHKB gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22M051017: view genomic region (about GC identifiers)

Start:	51,017,378 bp from pter	End:	51,039,884 bp from pter
Size:	22,507 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CHKB_HUMAN, Q9Y259 (See protein sequence)

Recommended Name: Choline/ethanolamine kinase

Size: 395 amino acids; 45271 Da

Subunit: Homodimer, and heterodimer with CHKA

Miscellaneous: This protein is produced by a bicistronic gene which also produces the CPT1B protein from a

non-overlapping reading frame

Sequence caution: Sequence=AAB03342.2; Type=Erroneous gene model prediction;

3 PDB 3D structures from and Proteopedia for CHKB:

2IG7 (3D)

3FEG (3D)

3LQ3 (3D)

Secondary accessions: A0PJM6 Q13388

Alternative splicing: 2 isoforms: Q9Y259-1 Q9Y259-2

Explore the universe of human proteins at neXtProt for CHKB: NX_Q9Y259

Explore proteomics data for CHKB at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See CHKB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005189.2

ENSEMBL proteins:

ENSP00000384400

Reactome Protein details: Q9Y259

CHKB Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CHKB (Choline Kinase beta)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins for CHKB OriGene Protein Over-expression Lysate for CHKB OriGene MassSpec for CHKB OriGene Custom Protein Services for CHKB
	GenScript Custom Purified and Recombinant Proteins Services for CHKB
	Novus Biologicals CHKB Protein Novus Biologicals CHKB Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for CHKB
	antibodies-online proteins for CHKB (4 products)
	antibodies-online peptides for CHKB

CHKB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for CHKB OriGene Custom Antibody Services for CHKB
	Novus Biologicals CHKB Antibodies
	Abcam antibodies for CHKB
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for CHKB
	antibodies-online antibodies for CHKB (30 products)

CHKB Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for CHKB
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CHKB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for CHKB
	antibodies-online kits for CHKB (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

1 InterPro protein domain:

IPR011009 Kinase-like_dom

Graphical View of Domain Structure for InterPro Entry Q9Y259

ProtoNet protein and cluster: Q9Y259

1 Blocks protein domain: IPB002573 Choline/ethanolamine kinase

UniProtKB/Swiss-Prot: CHKB_HUMAN, Q9Y259

Similarity: Belongs to the choline/ethanolamine kinase family

Find genes that share domains with CHKB About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: CHKB_HUMAN, Q9Y259

Function: Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine

biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with

ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis

Catalytic activity: ATP + choline = ADP + phosphocholine

Catalytic activity: ATP + ethanolamine = ADP + O-phosphoethanolamine

Biophysicochemical properties: Kinetic parameters: KM=0.57 mM for choline; KM=2.9 mM for ethanolamine;

Enzyme Numbers (IUBMB): EC 2.7.1.32¹ EC 2.7.1.82¹

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004103	choline kinase activity	IDA	19915674
GO:0004305	ethanolamine kinase activity	IDA	19915674
GO:0005524	ATP binding	IEA	--
GO:0016772	transferase activity, transferring phosphorus-containing groups	--	--

Find genes that share ontologies with CHKB About GenesLikeMe

Phenotypes:
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Chkb):

behavior/neurological	homeostasis/metabolism	limbs/digits/tail	muscle	nervous system
skeleton

Find genes that share phenotypes with CHKB About GenesLikeMe

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for CHKB

miRNA Products:		miRTarBase miRNAs that target CHKB: hsa-let-7b-5p (MIRT052190), hsa-mir-196b-5p (MIRT042674), hsa-mir-92a-3p (MIRT049124), hsa-mir-320a (MIRT044642), hsa-mir-346 (MIRT042718), hsa-mir-324-5p (MIRT043074), hsa-mir-744-5p (MIRT037448), hsa-mir-935 (MIRT036653), hsa-mir-1260b (MIRT052723)

		Block miRNA regulation of human, mouse, rat CHKB using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate CHKB:
		hsa-miR-146b-3p hsa-miR-4254 hsa-miR-874 hsa-miR-4308
		SwitchGear 3'UTR luciferase reporter plasmid: CHKB 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CHKB
		Predesigned siRNA for gene silencing in human, mouse, rat CHKB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CHKB

Clone Products:		OriGene clones in human, mouse for CHKB (see all 12) OriGene ORF clones in mouse, rat for CHKB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHKB (NM_005198)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHKB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHKB
		Addgene plasmids for CHKB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CHKB
		Browse ESI BIO Cell Lines and PureStem Progenitors for CHKB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHKB

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	5
peroxisome	3
cytosol	2
nucleus	2
extracellular	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

Find genes that share ontologies with CHKB About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for CHKB About

See pathways by source

Powered
by

SuperPath

Contained pathways About

Glycerophospholipid biosynthesis

Glycerophospholipid biosynthesis	0.64	Synthesis of PE	0.00
Phospholipid metabolism	0.64	Synthesis of PC	0.00
Glycerophospholipid metabolism	0.62

Metabolism

	Metabolism	0.38			Metabolism of lipids and lipoproteins	0.37
	Metabolic pathways	0.38

Mitochondrial LC-Fatty Acid Beta-Oxidation

Fatty Acid Beta Oxidation

0.35

Find genes that share SuperPaths with CHKB About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for CHKB

Fatty Acid Beta Oxidation

2 Reactome Pathways for CHKB

	Synthesis of PE
	Synthesis of PC

2 Kegg Pathways (Kegg details for CHKB):

	Glycerophospholipid metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: CHKB_HUMAN, Q9Y259

Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from

ethanolamine: step 1/3

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for CHKB
Interactions:

Search GeneGlobe Interaction Network for CHKB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CHKB (Q9Y259³ ENSP00000384400⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 82)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000206286	Q8N1B4³	I2D: score=1
ENSG00000224455	Q8N1B4³	I2D: score=1
ENSG00000225590	Q8N1B4³	I2D: score=1
ENSG00000228425	Q8N1B4³	I2D: score=1
ENSG00000236014	Q8N1B4³	I2D: score=1

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006646	phosphatidylethanolamine biosynthetic process	TAS	--
GO:0006656	phosphatidylcholine biosynthetic process	TAS	--
GO:0006657	CDP-choline pathway	IDA	19915674
GO:0044281	small molecule metabolic process	TAS	--

Find genes that share ontologies with CHKB About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for CHKB

6 HMDB Compounds for CHKB About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Choline	(2-Hydroxyethyl)trimethyl ammonium (see all 19)	62-49-7	--
Ethanolamine	1-Amino-2-hydroxyethane (see all 28)	141-43-5	--
O-Phosphoethanolamine	Phosphoryethanolamine (see all 28)	1071-23-4	--
Phosphorylcholine	Choline phosphate (see all 5)	3616-04-4	--

1 DrugBank Compound for CHKB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Choline	Bilineurine (see all 7)	62-49-7	enzyme	substrate	16371353 17236204

Selected Novoseek inferred chemical compound relationships for CHKB gene (see all 146) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
creatinine	95.3	1967	16324360 (4), 7736901 (3), 1764545 (3), 8873665 (3), 16267412 (3), 19177312 (3), 15675966 (3), 8797846 (2), 11932978 (2), 15306159 (2), 18381844 (2), 11258919 (2), 18572501 (2), 19534642 (2), 9914824 (2), 16463683 (2), 8504533 (2), 8463436 (2), 19421954 (2), 19049907 (2), 18652070 (2), 12139472 (2), 10336050 (2), 10596995 (2), 11502426 (2), 9538931 (2), 8129954 (2), 1446953 (2), 19139478 (2), 16516077 (2), 14650900 (2), 12181291 (2), 7695079 (2), 19826299 (2), 19734738 (2), 16537817 (2), 11978494 (2), 10460186 (2), 8894555 (2), 7594364 (2), 7923134 (2), 18371999 (2), 16633902 (2), 16609694 (2), 16679975 (2), 15619503 (2), 15115182 (2), 9736821 (2), 19332189 (2), 15504039 (2), 1859839 (2), 17333358 (2), 16388789 (2), 15861991 (2), 2337989 (1), 2366828 (1), 2115819 (1), 2385106 (1), 2102148 (1), 1993778 (1), 2004455 (1), 2030419 (1), 2050939 (1), 2051619 (1), 1711638 (1), 1877684 (1), 1909638 (1), 1655986 (1), 1952045 (1), 1961130 (1), 1768547 (1), 7752822 (1), 1790538 (1), 1536162 (1), 1597518 (1), 1606705 (1), 1386455 (1), 1470014 (1), 8469346 (1), 8472675 (1), 9216454 (1), 9152783 (1), 9132484 (1), 9003404 (1), 8985522 (1), 8958744 (1), 8814507 (1), 8800027 (1), 8712096 (1), 9810285 (1), 9809943 (1), 9777141 (1), 9746337 (1), 9745852 (1), 9659712 (1), 9635103 (1), 9596294 (1), 9479037 (1), 11018813 (1) (see top 4)
cyclocreatine	75.9	17	7923134 (3), 11745437 (2), 8042860 (1), 9888469 (1), 15748292 (1), 7670140 (1) (see top 4)
lactate	75.5	270	11108185 (3), 8557926 (3), 17650795 (3), 8358570 (2), 19057981 (2), 18001483 (2), 14642073 (2), 11710665 (2), 19131276 (2), 16324360 (2), 10485308 (2), 8319387 (2), 1655986 (1), 8273732 (1), 8608170 (1), 8985522 (1), 9152783 (1), 9283529 (1), 10029337 (1), 10905753 (1), 16388789 (1), 16505080 (1), 15535901 (1), 15754570 (1), 15306159 (1), 15302083 (1), 12578257 (1), 11789206 (1), 11189913 (1), 11266197 (1), 11104450 (1), 11018439 (1), 10611993 (1), 10573315 (1), 9458147 (1), 8925809 (1), 8526813 (1), 2371189 (1), 20508471 (1), 20411076 (1), 20373468 (1), 20203358 (1), 19782586 (1), 19787388 (1), 19254158 (1), 19077734 (1), 18337328 (1), 16519604 (1), 15565394 (1), 14694721 (1), 15155430 (1), 12750582 (1), 12688092 (1), 11960939 (1), 11549049 (1), 11156284 (1), 15636711 (1), 14652498 (1), 12577113 (1), 16032182 (1), 11533559 (1), 11240563 (1), 9459838 (1), 8833714 (1), 7776386 (1), 18184391 (1), 16394956 (1), 16328090 (1), 16481153 (1), 15976792 (1), 8353946 (1), 2357826 (1), 8678628 (1), 18971188 (1), 18663991 (1), 18305954 (1), 16998448 (1), 16572331 (1), 10370734 (1), 9641361 (1), 10682571 (1), 9212520 (1), 9005684 (1), 7538922 (1), 7967583 (1), 2228562 (1), 17532314 (1), 17126438 (1), 17402398 (1), 17239027 (1), 16505786 (1), 16151835 (1), 15143718 (1), 12921602 (1), 2311208 (1), 20306756 (1), 19457763 (1), 19223671 (1), 18021985 (1) (see top 4)
aspartate	71.7	140	19254158 (2), 19421954 (2), 12639201 (2), 14642073 (2), 15812463 (2), 1470014 (1), 8985522 (1), 9132484 (1), 9216454 (1), 9745852 (1), 10661020 (1), 12405670 (1), 15754570 (1), 15535901 (1), 18588751 (1), 2371189 (1), 8374980 (1), 9291634 (1), 10573315 (1), 10611993 (1), 11104450 (1), 12921602 (1), 2357826 (1), 20517747 (1), 18971188 (1), 18663991 (1), 16519604 (1), 16225097 (1), 15565394 (1), 15155430 (1), 12688092 (1), 10606828 (1), 9130176 (1), 8997467 (1), 8504533 (1), 1424434 (1), 1939492 (1), 2363384 (1), 2330742 (1), 18572209 (1), 11269976 (1), 9681595 (1), 9604030 (1), 9139272 (1), 10148188 (1), 1601350 (1), 19131276 (1), 18776092 (1), 17472818 (1), 12482620 (1), 7671876 (1), 7916242 (1), 8365392 (1), 1434588 (1), 2088650 (1), 2378136 (1), 8078622 (1), 19883162 (1), 17635574 (1), 17701751 (1), 16679975 (1), 15223701 (1), 16297323 (1), 19755312 (1), 19139478 (1), 18543598 (1), 18087083 (1), 16860175 (1), 16775544 (1), 12848792 (1), 16324360 (1), 16026778 (1), 14505535 (1), 15895207 (1), 15226782 (1), 14757204 (1), 12902208 (1), 10048552 (1), 18184391 (1), 15214854 (1), 12577113 (1), 12405702 (1), 9638076 (1), 9459838 (1), 8833714 (1), 2378131 (1), 10941812 (1), 10370734 (1), 10336050 (1), 10596995 (1), 10682571 (1), 9465772 (1), 9250517 (1), 9212520 (1), 20109103 (1), 20203358 (1), 15364008 (1), 16505786 (1), 17158079 (1) (see top 4)
alpha-hydroxybutyrate	71.2	9	2046229 (1), 9453514 (1), 10370734 (1), 18971188 (1), 2357826 (1), 1424434 (1), 10690308 (1), 9681595 (1), 19883162 (1) (see top 4)
phosphocreatine	69.3	60	19332463 (4), 8276423 (3), 9746337 (2), 8635232 (2), 11979563 (2), 8692275 (2), 1877684 (1), 8075616 (1), 12701805 (1), 15234108 (1), 9764442 (1), 18652071 (1), 11502426 (1), 9538931 (1), 16813275 (1), 8410707 (1), 19333390 (1), 17967437 (1), 14608589 (1), 11708401 (1), 9239671 (1), 18673182 (1), 7858128 (1), 18652070 (1), 8145276 (1), 16390274 (1), 9230121 (1), 1579047 (1), 11734556 (1), 9479037 (1) (see top 4)
alanine	50.5	62	12639201 (2), 9216454 (1), 11018813 (1), 15754570 (1), 15535901 (1), 8374980 (1), 8526813 (1), 9291634 (1), 10573315 (1), 10611993 (1), 15364008 (1), 16505786 (1), 17899190 (1), 20109103 (1), 7538922 (1), 10336050 (1), 10941812 (1), 15565394 (1), 7671876 (1), 7934584 (1), 2088650 (1), 16297323 (1), 19139478 (1), 18087083 (1), 16860175 (1), 16775544 (1), 11269976 (1), 20298135 (1), 20186101 (1), 17302377 (1), 16537817 (1), 15586397 (1), 11766073 (1), 11476029 (1), 10460186 (1), 8894531 (1), 1361697 (1), 17853285 (1), 18371999 (1), 18458712 (1), 17635574 (1), 16679975 (1), 15223701 (1), 12482620 (1), 1601350 (1), 17472818 (1), 16324360 (1), 15226782 (1), 16225097 (1), 16519604 (1), 20517747 (1), 7588456 (1), 8833714 (1), 9459838 (1), 12577113 (1), 8504533 (1), 9130176 (1), 10606828 (1), 10048552 (1) (see top 4)
adp	41.4	27	8276423 (3), 8797846 (2), 9479037 (1), 9746337 (1), 12701805 (1), 10692338 (1), 9309661 (1), 8692275 (1), 9538931 (1), 18375588 (1), 19228404 (1), 9366273 (1), 12181291 (1), 16813275 (1), 16793278 (1) (see top 4)
dantrolene	40.3	14	14649364 (3), 14719706 (3), 15717469 (2), 7486044 (2), 17868276 (1) (see top 4)
atp	40.3	98	10387096 (4), 19332463 (4), 9764442 (3), 15647364 (3), 9479037 (2), 8548904 (2), 9746337 (2), 19049907 (2), 8873665 (2), 9309661 (2), 2385106 (1), 11734556 (1), 17029789 (1), 1579047 (1), 11467829 (1), 19333390 (1), 17967437 (1), 17392597 (1), 9239671 (1), 8692275 (1), 10737943 (1), 9516180 (1), 14744260 (1), 9914824 (1), 9555058 (1), 7858128 (1), 7923134 (1), 19370404 (1), 16609694 (1), 11571592 (1), 10561506 (1), 9538931 (1), 1950416 (1), 18979206 (1), 18780799 (1), 18673182 (1), 11978494 (1), 18309274 (1), 16793278 (1), 16813275 (1), 10806211 (1), 7670140 (1), 8410707 (1), 19409453 (1), 19228404 (1), 15504039 (1), 10820214 (1), 17333358 (1), 12701805 (1), 1877684 (1), 8358570 (1), 8797846 (1) (see top 4)

Find genes that share compounds with CHKB About GenesLikeMe

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for CHKB gene (2 alternative transcripts):

NM_005198.4 NM_152253.1

Unigene Cluster for CHKB:

Choline kinase beta

Hs.654827 [show with all ESTs]

Unigene Representative Sequence: NM_005198

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000406938(uc003bmv.3) ENST00000492582(uc003bmt.2) ENST00000464225

ENST00000471515 ENST00000484266 ENST00000481673 ENST00000479003 ENST00000468532

ENST00000489453 ENST00000476289 ENST00000463053 ENST00000465842

miRNA Products:		Block miRNA regulation of human, mouse, rat CHKB using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate CHKB:
		hsa-miR-146b-3p hsa-miR-4254 hsa-miR-874 hsa-miR-4308
		SwitchGear 3'UTR luciferase reporter plasmid: CHKB 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for CHKB
		Predesigned siRNA for gene silencing in human, mouse, rat CHKB

Clone Products:		OriGene clones in human, mouse for CHKB (see all 12) OriGene ORF clones in mouse, rat for CHKB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHKB (NM_005198)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHKB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHKB
		Addgene plasmids for CHKB

Primer Products:		OriGene qPCR primer pairs and template standards for CHKB OriGene qSTAR qPCR primer pairs in human, mouse for CHKB
		Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat CHKB
		QuantiTect SYBR Green Assays in human, mouse, rat CHKB
		QuantiFast Probe-based Assays in human, mouse, rat CHKB

Additional mRNA sequence:

AB029886.1 AK314324.1 AL096780.1 AL096781.1 BC024286.1 BC050443.1 BC082263.1 BC101488.1

BC113521.1 BC141974.1 BC150582.1 CR456419.1

23 DOTS entries:

DT.100838063 DT.444144 DT.100866086 DT.95264267 DT.102835430 DT.95239121 DT.91825945 DT.97770629

DT.97791231 DT.100835220 DT.95073240 DT.97846203 DT.100866077 DT.100662643 DT.100767679 DT.120661725

DT.120661774 DT.87003770 DT.91978213 DT.120661788 DT.100653056 DT.100703190 DT.100866072

Selected AceView cDNA sequences (see all 50):

AW163316 CD364730 BM702182 BI494180 AA761255 BX331471 BM695582 BX355944

BX346470 W72661 AA149411 T53978 BE247467 AW771894 AA743869 AI268288

BU726575 AA465477 W73539 BM923362 W76418 AW612501 BX391233 AW157517

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHKB (see all 29) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	·
SP1:																			-		-				-				-																		-		-		-
SP2:
SP3:
SP4:
SP5:									-				-						-		-				-				-

ExUns:	13c	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d	^	16a	·	16b	·	16c	^	17a	·	17b	·	17c	·	17d	·	17e	^	18a	·	18b	·	18c	·	18d	^	19a	·	19b	·	19c	^	20a	·	20b	^	21a	·	21b	^
SP1:	-		-		-		-		-																		-		-																				-
SP2:							-		-																		-		-																				-
SP3:							-		-																		-		-																				-
SP4:																											-		-																				-
SP5:

ExUns:	22a	·	22b	·	22c	^	23a	·	23b	^	24	^	25a	·	25b	^	26a	·	26b	^	27a	·	27b	^	28	^	29	^	30	^	31a	·	31b	^	32	^	33a	·	33b	·	33c	^	34a	·	34b
SP1:							-		-				-										-																		-
SP2:							-		-				-										-																-		-
SP3:							-		-				-										-
SP4:							-		-				-										-																-		-
SP5:

ECgene alternative splicing isoforms for CHKB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

CHKB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTGGCAGGC

About this image

CHKB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 5) fully expand


Brain (Nervous System) fully expand to see all 5 entries
Cerebral Cortex

Neural Tube (Nervous System) fully expand to see all 3 entries
Metencephalon

Eye (Sensory Organs)
Lens

Heart (Cardiovascular System)

Placenta (Extraembryonic Tissues)

CHKB Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

CHKB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.654827

Custom PCR Arrays for CHKB

Primer Products:		OriGene qPCR primer pairs and template standards for CHKB OriGene qSTAR qPCR primer pairs in human, mouse for CHKB
		Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat CHKB
		QuantiTect SYBR Green Assays in human, mouse, rat CHKB
		QuantiFast Probe-based Assays in human, mouse, rat CHKB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHKB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHKB gene from Selected species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Chkb^{1 , 5}	choline kinase beta^{1, 5}	85.11(n)¹ 86.04(a)¹		15 (44.89 cM)⁵ 12651¹ NM_007692.6¹ NP_031718.1¹ 89416405⁵
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	65(a)	1 → many	AAWZ02039146(163-9342)
tropical clawed frog (Xenopus tropicalis)	Amphibia	chkb¹	choline kinase beta	60.59(n) 65.24(a)		100145186 NM_001126676.1 NP_001120148.1
zebrafish (Danio rerio)	Actinopterygii	chkb¹	choline kinase beta	62.95(n) 63.14(a)		563589 NM_001100012.2 NP_001093482.1
fruit fly (Drosophila melanogaster)	Insecta	CG2201¹	CG2201	49.46(n) 39.73(a)		35417 NM_165387.3 NP_724349.1
worm (Caenorhabditis elegans)	Secernentea	cka-1¹	cka-1	49.95(n) 43.32(a)		177807 NM_001136377.2 NP_001129849.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	EKI1⁶ CKI1⁶	Ethanolamine kinase, primarily responsible for pho... Choline kinase, catalyzing the first step in phosp...	16(a) 16(a)	many ↔ many many ↔ many	IV(751631-753235) YDR147W XII(408445-410193) YLR133W
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G74320¹	AT1G74320	46.89(n) 36.34(a)		843772 NM_106092.3 NP_177572.2
rice (Oryza sativa)	Liliopsida	Os05g0535400¹	Os05g0535400	50(n) 34.62(a)		9268113 NM_001187573.1 NP_001174502.1

ENSEMBL Gene Tree for CHKB (if available)
TreeFam Gene Tree for CHKB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for CHKB gene

CHKA² ETNK1² CHKB-CPT1B² ETNK2²

2 SIMAP similar genes for CHKB using alignment to 1 protein entry: CHKB_HUMAN:

CHKA ETNK2

Find genes that share paralogs with CHKB About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs131754^1,2	C	--	33913778(-)	`TTTTT-/TTTT /TTTTTGAGAC`	1	--	us2k¹		0	--	--	--	--
rs963980^1,2	C,F,H	--	34965120(-)	`CAATGT/GGAGGT`	1	--	us2k¹		12		MN NA WA CSA	437
rs114371803^1,2	C,F	--	34965176(+)	`CCCCAG/AGCTAG`	1	--	us2k¹		1		WA	118
rs79830034^1,2	C	--	34965362(+)	`AAATCG/TGAGTC`	1	--	us2k¹		0	--	--	--	--
rs131755^1,2	C,F,A,H	--	34965522(-)	`accacA/Gcccgg`	1	--	us2k¹		7		NS NA WA EA	484
rs6010015^1,2	C,A	--	34965524(+)	`GGGCGT/CGGTGG`	1	--	us2k¹		5		WA CSA NA EA	244
rs6010016^1,2	C,A	--	34965572(+)	`CGGGCG/AGATCA`	1	--	us2k¹ tfbs³		2		WA CSA	3
rs181294186^1,2		--	34965646(+)	`ACAAAA/GATTAG`	1	--	us2k¹		0	--	--	--	--
rs2283674^1,2	C,F	--	34965703(+)	`GAGGCG/ATGACA`	1	--	us2k¹		6		NA WA CSA EA	363
rs185977127^1,2	C	--	34965760(+)	`CTGAGC/G/TGACAG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CHKB (51017378 - 51039884 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for CHKB (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
nsv914559	CNV	Loss	21882294
nsv915495	CNV	Loss	21882294
nsv914561	CNV	Loss	21882294
dgv5062n71	CNV	Loss	21882294
dgv5068n71	CNV	Loss	21882294
nsv914525	CNV	Loss	21882294
nsv914543	CNV	Loss	21882294
nsv834239	CNV	Loss	17160897
dgv5066n71	CNV	Loss	21882294
nsv471224	CNV	Loss	18288195

Human Gene Mutation Database (HGMD): CHKB

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing CHKB

DNA2.0 Custom Variant and Variant Library Synthesis for CHKB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 612395
OMIM disorders: 602541
Selected diseases for CHKB (see all 46):
About MalaCards

spermatic cord torsion japanese spotted fever cytoplasmic body myopathy fainting

cardiac rupture distal muscular dystrophy adult dermatomyositis proximal spinal muscular atrophy

compartment syndrome muscular dystrophy, congenital, megaconial type chkb-related muscle diseases acute myocardial infarction

myositis gas gangrene creatine phosphokinase, elevated serum pericardial effusion

neuroleptic malignant syndrome chondroblastoma endometritis myoblastoma

1 inferred disease relationship from the University of Copenhagen DISEASES database for CHKB:

Sleep disorder

Find genes that share disorders with CHKB About GenesLikeMe

Selected Novoseek inferred disease relationships for CHKB gene (see all 97) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rhabdomyolysis	84	82	19534642 (4), 20014178 (4), 1952045 (2), 14655521 (2) (see all 46)
acute myocardial infarction	78.9	102	11253625 (3), 7666339 (3), 8164150 (2), 8937582 (2) (see all 79)
creatine phosphokinase, elevated serum	78.6	4	9141928 (1), 16502425 (1), 11993531 (1), 11532557 (1)
myopathy	76.3	60	15367725 (3), 19078624 (2), 17327290 (2), 19833260 (2) (see all 48)
polymyositis	71.8	18	8480146 (2), 2088650 (2), 9745852 (1), 7914924 (1) (see all 13)
myositis	71.7	30	7474450 (3), 8480146 (2), 17763431 (2), 11317279 (1) (see all 22)
myocardial infarction	70.7	87	18328834 (3), 8557926 (3), 19050596 (2), 9115102 (2) (see all 61)
muscular dystrophy duchenne	65.3	8	10825803 (2), 9829280 (1), 11269976 (1), 11532557 (1) (see all 7)
infarct	64.1	94	16645412 (7), 19050596 (4), 15546288 (4), 9453514 (4) (see all 47)
neuroleptic malignant syndrome	60.2	6	8101383 (1), 16453254 (1), 16145285 (1), 19952877 (1) (see all 6)

Genetic Association Database (GAD): CHKB
Human Genome Epidemiology (HuGE) Navigator: CHKB (7 documents)

Export disorders for CHKB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for CHKB gene, integrated from 10 sources (see all 1090):
(articles sorted by number of sources associating them with CHKB)

Utopia: connect your pdf to the dynamic
world of online information

Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)^{1, 4} RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia). (PubMed id 19404393)^{1, 4} Miyagawa T....Tokunaga K. (PLoS ONE 2009)
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. (PubMed id 18996102)^{1, 4} RuaA+o G....Hanks S. ( international journal of clinical chemistry 2009)
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. (PubMed id 19915674)^{1, 2} Gallego-Ortega D.... Lacal J.C. (PLoS ONE 2009)
Variant between CPT1B and CHKB associated with susceptibility to narcolepsy. (PubMed id 18820697)^{1, 4} Miyagawa T....Tokunaga K. (Nat. Genet. 2008)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (Genome Biol. 2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Structure and function of choline kinase isoforms in mammalian cells. (PubMed id 15003397)^{1, 3} Aoyama C....Ishidate K. (Prog. Lipid Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 1120	HGNC: 1938	AceView: CHKB	Ensembl:ENSG00000100288	euGenes: HUgn1120
ECgene: CHKB	Kegg: 1120	H-InvDB: CHKB

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for CHKB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CHKB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for CHKB gene:
Search GeneIP for patents involving CHKB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Recombinant/Natural Proteins for CHKB (Choline Kinase beta)		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for CHKB		OriGene RNAi products in human, mouse, rat for CHKB
	OriGene qPCR primer pairs and template standards for CHKB		OriGene Protein Over-expression Lysate for CHKB
	OriGene MassSpec for CHKB		OriGene clones in human, mouse for CHKB
	OriGene qSTAR qPCR primer pairs in human, mouse for CHKB		OriGene Purified Protein for CHKB
	OriGene ORF clones in mouse, rat for CHKB		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CHKB		OriGene Custom Protein Services for CHKB

	Block miRNA regulation of human, mouse, rat CHKB using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing CHKB
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHKB		Predesigned siRNA for gene silencing in human, mouse, rat CHKB
	QuantiFast Probe-based Assays in human, mouse, rat CHKB		QuantiTect SYBR Green Assays in human, mouse, rat CHKB
	Custom PCR Arrays for CHKB		Search Chromatin IP Primers for CHKB
	Search Pre-validated RT² qPCR Primer Assays in human, mouse, rat CHKB		Search GeneGlobe Interaction Network for CHKB
	Regulatory tfbs in CHKB promoter

	GenScript Custom Purified and Recombinant Proteins Services for CHKB		GenScript cDNA clones with any tag delivered in your preferred vector for CHKB
	GenScript Custom Assay Services for CHKB		GenScript Custom overexpressing Cell Line Services for CHKB
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for CHKB

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CHKB antibodies
	CHKB proteins
	CHKB lysates

	Antibodies for CHKB
	See all of Abcam's Antibodies, Kits and Proteins for CHKB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Browse ESI BIO Cell Lines and PureStem Progenitors for CHKB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHKB

	SwitchGear 3'UTR luciferase reporter plasmids for CHKB
	SwitchGear Promoter luciferase reporter plasmids for CHKB

ThermoFisher Antibodies for CHKB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHKB

Browse compounds at ApexBio

Addgene plasmids for CHKB

	Search eBioscience for proteins for CHKB
	Search eBioscience for elisas for CHKB
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for CHKB

	antibodies-online antibodies for CHKB (30 products)
	antibodies-online kits for CHKB (6 products)
	antibodies-online peptides for CHKB
	antibodies-online proteins for CHKB (4 products)

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CHKB gene at Home site.

Version: 3.12.300 21 Jan 2015
hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

CHKB Gene

Choline Kinase Beta

Aliases
for CHKB gene

Summaries
for CHKB gene

Genomic Views
for CHKB gene

Proteins
for CHKB gene

CHKB Human Recombinant Protein Products:

CHKB Antibody Products:

CHKB Assay Products:

Domains /
Families
for CHKB gene

Function
for CHKB gene

Localization
for CHKB gene

Pathways & Interactions
for CHKB gene

Drugs & Compounds
for CHKB gene

Transcripts
for CHKB gene

Expression
for CHKB gene

Orthologs
for CHKB gene

Paralogs
for CHKB gene

Genomic Variants
for CHKB gene

Disorders / Diseases
for CHKB gene

Publications
for CHKB gene

External Searches for CHKB gene

Genome Databases showing CHKB gene

Other Databases showing CHKB gene

Specialized Databases showing CHKB gene

Intellectual Property
for CHKB gene

Products
for CHKB gene

View Random Gene

Limb girdle
LGMD2I
MIYOSHI MYOPATHY
MYOPATHY, CONGENITAL
Pericardial Effusion
Acute myocardial infarction
dysplasia
Rhabdomyolysis
Colitis Ulcerative
Pregnancy Tubal
Myocardial Ischemia
Ischemia
Metaplasia
Anterior myocardial infarction
Edema
HYPOTHYROIDISM PRIMARY
Schizophrenia
Asthma
Neuromuscular Diseases
cell damage
Hemolysis
Epidermoid Cyst
Poisoning
Cardiomyopathy
Acute Psychosis
Sporadic Inclusion Body Myositis
Shock
Cardiac Death
effusion
Coronary Vasospasm
Malnutrition
Compartment Syndromes
Inflammation
Neuroleptic Malignant Syndrome
Arrhythmia
Muscular Dystrophy Duchenne
Cysts
metabolic acidosis
Anemia
psychiatric disorder
Renal Failure
Rheumatoid Arthritis
Tumors
Metastasis
Necrosis
metabolic disorder
Renal Failure Acute
FIBRILLATION
Coronary Heart Disease
Tachycardia
Chronic Disease
Melanoma
Coronary Occlusion
Parkinson Disease
Muscular Dystrophies
Cardiac Rupture
Atrial Fibrillation
McArdles Disease
Meningitis Aseptic
INFARCT
Abortion Missed
Hypothyroidism
Alzheimers Disease
Heart Failure Congestive
Ventricular Dysfunction Left
Contracture
Myopathies Idiopathic Inflammatory
Dermatomyositis
MUSCLE NECROSIS
Myocarditis
Myopathy
Amyotrophic Lateral Sclerosis
Myocardial Infarction
HEART FAILURE
Multiple Organ Failure
Coronary Artery Disease
Response Acute Phase
Heart Diseases
HIV Infections
Liver Dysfunction
Scar
Mitochondrial Myopathies
Picks Disease
SMA III
Atrophy
Hematoma
Pregnancy Ectopic
Cholesteatoma Middle Ear
Myositis
Myotonic Dystrophy
Hashimotos Thyroiditis
CREATINE PHOSPHOKINASE, ELEVATED SERUM
DISTAL MUSCULAR DYSTROPHY
Dilated Cardiomyopathy
Polymyositis
Cardiac Arrest
Ventricular Fibrillation

GeneCards Plus

Advanced Search

Export list of displayed genes

CHKB Gene

Choline Kinase Beta

Aliasesfor CHKB gene

Summariesfor CHKB gene

Genomic Viewsfor CHKB gene

Proteinsfor CHKB gene

CHKB Human Recombinant Protein Products:

CHKB Antibody Products:

CHKB Assay Products:

Domains /Familiesfor CHKB gene

Functionfor CHKB gene

Localizationfor CHKB gene

Pathways & Interactionsfor CHKB gene

Drugs & Compoundsfor CHKB gene

Transcriptsfor CHKB gene

Expression for CHKB gene

Orthologsfor CHKB gene

Paralogsfor CHKB gene

Genomic Variantsfor CHKB gene

Disorders / Diseasesfor CHKB gene

Publicationsfor CHKB gene

External Searches for CHKB gene

Genome Databases showing CHKB gene

Other Databases showing CHKB gene

Specialized Databases showing CHKB gene

Intellectual Propertyfor CHKB gene

Productsfor CHKB gene

View Random Gene

Aliases
for CHKB gene

Summaries
for CHKB gene

Genomic Views
for CHKB gene

Proteins
for CHKB gene

Domains /
Families
for CHKB gene

Function
for CHKB gene

Localization
for CHKB gene

Pathways & Interactions
for CHKB gene

Drugs & Compounds
for CHKB gene

Transcripts
for CHKB gene

Expression
for CHKB gene

Orthologs
for CHKB gene

Paralogs
for CHKB gene

Genomic Variants
for CHKB gene

Disorders / Diseases
for CHKB gene

Publications
for CHKB gene

Intellectual Property
for CHKB gene

Products
for CHKB gene