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Aliases for CHKA Gene

Aliases for CHKA Gene

  • Choline Kinase Alpha 2 3
  • CHK 3 4 6
  • Ethanolamine Kinase 3 4
  • CHETK-Alpha 3 4
  • CKI 3 4
  • EK 3 4
  • CK 3 4
  • Choline Kinase 2
  • EC 2.7.1.32 4
  • EC 2.7.1.82 4

External Ids for CHKA Gene

Previous Symbols for CHKA Gene

  • CHK

Summaries for CHKA Gene

Entrez Gene Summary for CHKA Gene

  • The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHKA Gene

CHKA (Choline Kinase Alpha) is a Protein Coding gene. Diseases associated with CHKA include bronchiolitis obliterans organizing pneumonia and compartment syndrome. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and drug binding. An important paralog of this gene is CHKB.

UniProtKB/Swiss-Prot for CHKA Gene

  • Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Gene Wiki entry for CHKA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHKA Gene

Genomics for CHKA Gene

Genomic Location for CHKA Gene

Start:
68,052,859 bp from pter
End:
68,121,444 bp from pter
Size:
68,586 bases
Orientation:
Minus strand

Genomic View for CHKA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHKA Gene

Regulatory Elements for CHKA Gene

Proteins for CHKA Gene

  • Protein details for CHKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35790-CHKA_HUMAN
    Recommended name:
    Choline kinase alpha
    Protein Accession:
    P35790
    Secondary Accessions:
    • Q8NE29

    Protein attributes for CHKA Gene

    Size:
    457 amino acids
    Molecular mass:
    52249 Da
    Quaternary structure:
    • Heterodimer with CHKB (By similarity). Homodimer.

    Three dimensional structures from OCA and Proteopedia for CHKA Gene

    Alternative splice isoforms for CHKA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHKA Gene

Proteomics data for CHKA Gene at MOPED

Post-translational modifications for CHKA Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys195

Other Protein References for CHKA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHKA Gene

Domains for CHKA Gene

Protein Domains for CHKA Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CHKA_HUMAN
Family:
  • Belongs to the choline/ethanolamine kinase family.:
    • P35790
genes like me logo Genes that share domains with CHKA: view

No data available for Gene Families for CHKA Gene

Function for CHKA Gene

Molecular function for CHKA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.2 mM for choline {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=0.4 mM for ATP {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=12 mM for ethanolamine {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674};
UniProtKB/Swiss-Prot CatalyticActivity: ATP + choline = ADP + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot Function: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Enzyme Numbers (IUBMB) for CHKA Gene

Gene Ontology (GO) - Molecular Function for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004103 choline kinase activity IDA 19915674
GO:0004104 cholinesterase activity IEA --
GO:0004305 ethanolamine kinase activity IDA 19915674
GO:0004871 signal transducer activity TAS 10363580
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CHKA: view
genes like me logo Genes that share phenotypes with CHKA: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHKA Gene

Localization for CHKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHKA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHKA Gene COMPARTMENTS Subcellular localization image for CHKA gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHKA: view

Pathways for CHKA Gene

genes like me logo Genes that share pathways with CHKA: view

UniProtKB/Swiss-Prot P35790-CHKA_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1
  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3

Gene Ontology (GO) - Biological Process for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10363580
GO:0006644 phospholipid metabolic process TAS --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway TAS 10363580
genes like me logo Genes that share ontologies with CHKA: view

Compounds for CHKA Gene

(1079) HMDB Compounds for CHKA Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Choline
  • (2-Hydroxyethyl)trimethyl ammonium
62-49-7
PC(14:0/14:0)
  • Phosphatidylcholine(14:0/14:0)
Not Available
PC(14:0/14:1(9Z))
  • Phosphatidylcholine(14:0/14:1)
Not Available

(1) Drugbank Compounds for CHKA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Choline
  • Bilineurine
62-49-7 enzyme substrate

(80) Novoseek inferred chemical compound relationships for CHKA Gene

Compound -log(P) Hits PubMed IDs
creatinine 82.4 112
cyclocreatine 68.3 2
phosphocreatine 53.2 13
gemfibrozil 49.8 4
lipid 48.9 29
genes like me logo Genes that share compounds with CHKA: view

Transcripts for CHKA Gene

Unigene Clusters for CHKA Gene

Choline kinase alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHKA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d
SP1: - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for CHKA Gene

GeneLoc Exon Structure for
CHKA
ECgene alternative splicing isoforms for
CHKA

Expression for CHKA Gene

mRNA expression in normal human tissues for CHKA Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHKA Gene

SOURCE GeneReport for Unigene cluster for CHKA Gene Hs.77221

genes like me logo Genes that share expressions with CHKA: view

Orthologs for CHKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHKA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHKA 36
  • 99.74 (n)
  • 100 (a)
CHKA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHKA 36
  • 88.07 (n)
  • 91.5 (a)
CHKA 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHKA 36
  • 88.6 (n)
  • 91.3 (a)
CHKA 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chka 36
  • 86.39 (n)
  • 88.08 (a)
Chka 16
Chka 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHKA 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHKA 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chka 36
  • 86.44 (n)
  • 89.43 (a)
chicken
(Gallus gallus)
Aves CHKA 36
  • 75.88 (n)
  • 76 (a)
CHKA 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHKA 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12834 36
tropical clawed frog
(Silurana tropicalis)
Amphibia chka 36
  • 68.64 (n)
  • 72.35 (a)
zebrafish
(Danio rerio)
Actinopterygii chka 36
  • 70.11 (n)
  • 70.67 (a)
chka 37
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2201 37
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cka-1 37
  • 30 (a)
ManyToMany
cka-2 36
  • 51.96 (n)
  • 43.55 (a)
cka-2 37
  • 35 (a)
ManyToMany
ckb-1 37
  • 27 (a)
ManyToMany
ckb-2 37
  • 24 (a)
ManyToMany
ckb-3 37
  • 24 (a)
ManyToMany
ckb-4 37
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKI1 37
  • 17 (a)
ManyToMany
EKI1 37
  • 17 (a)
ManyToMany
EKI1 39
thale cress
(Arabidopsis thaliana)
eudicotyledons CK1 36
  • 46.39 (n)
  • 36.25 (a)
rice
(Oryza sativa)
Liliopsida Os01g0183000 36
  • 48.49 (n)
  • 38.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
Species with no ortholog for CHKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHKA Gene

ENSEMBL:
Gene Tree for CHKA (if available)
TreeFam:
Gene Tree for CHKA (if available)

Paralogs for CHKA Gene

Paralogs for CHKA Gene

Selected SIMAP similar genes for CHKA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHKA: view

Variants for CHKA Gene

Sequence variations from dbSNP and Humsavar for CHKA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1703431 -- 68,055,847(-) ggctg(A/G)tctcg intron-variant
rs1703432 -- 68,055,842(-) gtctc(A/G)aactc intron-variant
rs1703439 -- 68,080,361(+) ttttt(C/T)gcatt intron-variant
rs1793253 -- 68,078,961(-) tctcc(A/C)aaaaa intron-variant
rs2298838 -- 68,069,910(-) GTAGA(A/G)TGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHKA Gene

Variant ID Type Subtype PubMed ID
dgv394e1 CNV Complex 17122850
nsv469856 CNV Gain 16826518
dgv1203n71 CNV Loss 21882294
dgv1204n71 CNV Loss 21882294
nsv825963 CNV Gain 20364138
nsv469964 CNV Loss 18288195
dgv1207n71 CNV Loss 21882294
nsv897852 CNV Gain 21882294
dgv1208n71 CNV Loss 21882294
nsv897855 CNV Loss 21882294
nsv825965 CNV Gain 20364138
esv2677355 CNV Deletion 23128226
nsv371 CNV Loss 18451855

Relevant External Links for CHKA Gene

HapMap Linkage Disequilibrium report
CHKA

Disorders for CHKA Gene

(1) University of Copenhagen DISEASES for CHKA Gene

(85) Novoseek inferred disease relationships for CHKA Gene

Disease -log(P) Hits PubMed IDs
rhabdomyolysis 67.6 11
myopathy 62.8 6
lipid storage myopathy 56.9 1
myositis 46.2 4
polymyositis 46 5

Relevant External Links for CHKA

Genetic Association Database (GAD)
CHKA
Human Genome Epidemiology (HuGE) Navigator
CHKA
genes like me logo Genes that share disorders with CHKA: view

No data available for UniProtKB/Swiss-Prot for CHKA Gene

Publications for CHKA Gene

  1. Structure and function of choline kinase isoforms in mammalian cells. (PMID: 15003397) Aoyama C. … Ishidate K. (Prog. Lipid Res. 2004) 2 3 23
  2. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. (PMID: 19915674) Gallego-Ortega D. … Lacal J.C. (PLoS ONE 2009) 3 4 23
  3. Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation. (PMID: 1618328) Hosaka K. … Yamashita S. (FEBS Lett. 1992) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. CHKA and PCYT1A gene polymorphisms, choline intake and spina bifida risk in a California population. (PMID: 17184542) Enaw J.O. … Finnell R.H. (BMC Med 2006) 3 49

Products for CHKA Gene

  • Addgene plasmids for CHKA

Sources for CHKA Gene

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