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Aliases for CHKA Gene

Aliases for CHKA Gene

  • Choline Kinase Alpha 2 3
  • Ethanolamine Kinase 3 4
  • CHETK-Alpha 3 4
  • CHK 3 4
  • CKI 3 4
  • EK 3 4
  • CK 3 4
  • Choline Kinase 2
  • EC 2.7.1.32 4
  • EC 2.7.1.82 4

External Ids for CHKA Gene

Previous HGNC Symbols for CHKA Gene

  • CHK

Previous GeneCards Identifiers for CHKA Gene

  • GC11M067596
  • GC11M067576
  • GC11M067820
  • GC11M064155

Summaries for CHKA Gene

Entrez Gene Summary for CHKA Gene

  • The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHKA Gene

CHKA (Choline Kinase Alpha) is a Protein Coding gene. Diseases associated with CHKA include chanarin-dorfman syndrome and small cell carcinoma of the bladder. Among its related pathways are Metabolism and Glycerophospholipid biosynthesis. GO annotations related to this gene include protein homodimerization activity and signal transducer activity. An important paralog of this gene is CHKB.

UniProtKB/Swiss-Prot for CHKA Gene

  • Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Gene Wiki entry for CHKA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHKA Gene

Genomics for CHKA Gene

Regulatory Elements for CHKA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHKA Gene

Chromosome:
11
Start:
68,052,859 bp from pter
End:
68,121,444 bp from pter
Size:
68,586 bases
Orientation:
Minus strand

Genomic View for CHKA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHKA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHKA Gene

Proteins for CHKA Gene

  • Protein details for CHKA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35790-CHKA_HUMAN
    Recommended name:
    Choline kinase alpha
    Protein Accession:
    P35790
    Secondary Accessions:
    • Q8NE29

    Protein attributes for CHKA Gene

    Size:
    457 amino acids
    Molecular mass:
    52249 Da
    Quaternary structure:
    • Heterodimer with CHKB (By similarity). Homodimer.

    Three dimensional structures from OCA and Proteopedia for CHKA Gene

    Alternative splice isoforms for CHKA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHKA Gene

Proteomics data for CHKA Gene at MOPED

Post-translational modifications for CHKA Gene

  • Ubiquitination at Lys 195
  • Modification sites at PhosphoSitePlus

Other Protein References for CHKA Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CHKA (CHKA)

No data available for DME Specific Peptides for CHKA Gene

Domains & Families for CHKA Gene

Protein Domains for CHKA Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CHKA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35790

UniProtKB/Swiss-Prot:

CHKA_HUMAN :
  • Belongs to the choline/ethanolamine kinase family.
Family:
  • Belongs to the choline/ethanolamine kinase family.
genes like me logo Genes that share domains with CHKA: view

No data available for Gene Families for CHKA Gene

Function for CHKA Gene

Molecular function for CHKA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.2 mM for choline {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=0.4 mM for ATP {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674}; KM=12 mM for ethanolamine {ECO:0000269 PubMed:17007874, ECO:0000269 PubMed:19915674};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + choline = ADP + phosphocholine.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ethanolamine = ADP + O-phosphoethanolamine.
UniProtKB/Swiss-Prot Function:
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.

Enzyme Numbers (IUBMB) for CHKA Gene

Gene Ontology (GO) - Molecular Function for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004103 choline kinase activity IDA 19915674
GO:0004104 cholinesterase activity IEA --
GO:0004305 ethanolamine kinase activity IDA 19915674
GO:0004871 signal transducer activity TAS 10363580
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CHKA: view
genes like me logo Genes that share phenotypes with CHKA: view

Animal Model Products

miRNA for CHKA Gene

miRTarBase miRNAs that target CHKA

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHKA

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CHKA Gene

Localization for CHKA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHKA Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHKA Gene COMPARTMENTS Subcellular localization image for CHKA gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CHKA: view

Pathways & Interactions for CHKA Gene

genes like me logo Genes that share pathways with CHKA: view

Pathways by source for CHKA Gene

UniProtKB/Swiss-Prot P35790-CHKA_HUMAN

  • Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1
  • Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3

Gene Ontology (GO) - Biological Process for CHKA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 10363580
GO:0006644 phospholipid metabolic process TAS --
GO:0006646 phosphatidylethanolamine biosynthetic process TAS --
GO:0006656 phosphatidylcholine biosynthetic process TAS --
GO:0006657 CDP-choline pathway TAS 10363580
genes like me logo Genes that share ontologies with CHKA: view

No data available for SIGNOR curated interactions for CHKA Gene

Drugs & Compounds for CHKA Gene

(49) Drugs for CHKA Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Choline Approved Nutra Enzyme, substrate 122
Adenosine triphosphate Approved Nutra 0
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Colchicine Approved Pharma Antagonist Tubulin Inhibitor 103
Dexamethasone Approved, Investigational Pharma Agonist 1806

(37) Additional Compounds for CHKA Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7, 63-89-8
Phosphatidylcholines Group B
  • 1-(1-Enyl-palmitoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(16:0/18:4)
  • GPCho(16:0/18:4n3)
  • GPCho(16:0/18:4w3)
  • GPCho(34:4)
88542-95-4
4-Hydroxynonenal
  • 4-Hydroxy-2,3-nonenal
  • 4-Hydroxy-2-Nonenal
  • 4-Hydroxynon-2-enal
  • 4-Hydroxynonenal
  • trans-4-Hydroxy-2-nonenal
75899-68-2
genes like me logo Genes that share compounds with CHKA: view

Transcripts for CHKA Gene

Unigene Clusters for CHKA Gene

Choline kinase alpha:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHKA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHKA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c · 14d
SP1: - - - - -
SP2: - - - - - -
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for CHKA Gene

GeneLoc Exon Structure for
CHKA
ECgene alternative splicing isoforms for
CHKA

Expression for CHKA Gene

mRNA expression in normal human tissues for CHKA Gene

Protein differential expression in normal tissues from HIPED for CHKA Gene

This gene is overexpressed in Lung (55.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHKA Gene



SOURCE GeneReport for Unigene cluster for CHKA Gene Hs.77221

genes like me logo Genes that share expression patterns with CHKA: view

Protein tissue co-expression partners for CHKA Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHKA Gene

Orthologs for CHKA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHKA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHKA 35
  • 88.07 (n)
  • 91.5 (a)
CHKA 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHKA 35
  • 88.6 (n)
  • 91.3 (a)
CHKA 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chka 35
  • 86.39 (n)
  • 88.08 (a)
Chka 16
Chka 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHKA 35
  • 99.74 (n)
  • 100 (a)
CHKA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chka 35
  • 86.44 (n)
  • 89.43 (a)
oppossum
(Monodelphis domestica)
Mammalia CHKA 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHKA 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHKA 35
  • 75.88 (n)
  • 76 (a)
CHKA 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHKA 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chka 35
  • 68.64 (n)
  • 72.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12834 35
zebrafish
(Danio rerio)
Actinopterygii chka 35
  • 70.11 (n)
  • 70.67 (a)
chka 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2201 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cka-2 35
  • 51.96 (n)
  • 43.55 (a)
cka-1 36
  • 30 (a)
ManyToMany
cka-2 36
  • 35 (a)
ManyToMany
ckb-1 36
  • 27 (a)
ManyToMany
ckb-2 36
  • 24 (a)
ManyToMany
ckb-3 36
  • 24 (a)
ManyToMany
ckb-4 36
  • 25 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CKI1 36
  • 17 (a)
ManyToMany
EKI1 36
  • 17 (a)
ManyToMany
EKI1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons CK1 35
  • 46.39 (n)
  • 36.25 (a)
rice
(Oryza sativa)
Liliopsida Os01g0183000 35
  • 48.49 (n)
  • 38.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for CHKA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHKA Gene

ENSEMBL:
Gene Tree for CHKA (if available)
TreeFam:
Gene Tree for CHKA (if available)

Paralogs for CHKA Gene

Paralogs for CHKA Gene

(2) SIMAP similar genes for CHKA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHKA: view

Variants for CHKA Gene

Sequence variations from dbSNP and Humsavar for CHKA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2512608 -- 68,086,206(+) CTACT(C/T)GGGAA intron-variant
rs2512611 -- 68,074,902(+) TCTCA(C/T)AGGAG intron-variant
rs2512612 -- 68,077,412(+) GGGGG(C/T)TGGAC intron-variant
rs2512613 -- 68,083,969(+) GCCGG(C/G/T)GGGGG intron-variant, upstream-variant-2KB
rs3133327 -- 68,087,165(+) GAAAC(C/G)AAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHKA Gene

Variant ID Type Subtype PubMed ID
dgv394e1 CNV Complex 17122850
nsv469856 CNV Gain 16826518
dgv1203n71 CNV Loss 21882294
dgv1204n71 CNV Loss 21882294
nsv825963 CNV Gain 20364138
nsv469964 CNV Loss 18288195
dgv1207n71 CNV Loss 21882294
nsv897852 CNV Gain 21882294
dgv1208n71 CNV Loss 21882294
nsv897855 CNV Loss 21882294
nsv825965 CNV Gain 20364138
esv2677355 CNV Deletion 23128226
nsv371 CNV Loss 18451855

Variation tolerance for CHKA Gene

Residual Variation Intolerance Score: 28.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHKA Gene

HapMap Linkage Disequilibrium report
CHKA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHKA Gene

Disorders for CHKA Gene

MalaCards: The human disease database

(6) MalaCards diseases for CHKA Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
chanarin-dorfman syndrome
  • cds
small cell carcinoma of the bladder
  • poorly differentiated neuroendocrine carcinoma of the bladder
microinvasive gastric cancer
  • early gastric cancer
muscle disorders
  • myopathy
leukomalacia
- elite association
Search CHKA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHKA

Genetic Association Database (GAD)
CHKA
Human Genome Epidemiology (HuGE) Navigator
CHKA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHKA
genes like me logo Genes that share disorders with CHKA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHKA Gene

Publications for CHKA Gene

  1. Structure and function of choline kinase isoforms in mammalian cells. (PMID: 15003397) Aoyama C. … Ishidate K. (Prog. Lipid Res. 2004) 2 23 67
  2. Gemfibrozil-induced myositis in a patient with normal renal function. (PMID: 19934390) Hahn M. … McFarland M.S. (Ann Pharmacother 2010) 23 67
  3. Beware of 'normal' creatine kinase levels in HIV-associated polymyositis. (PMID: 20459937) Kenyon C. … Heckmann J.M. (S. Afr. Med. J. 2010) 23 67
  4. Nutritional supplementation, performance, and oxidative stress in college soccer players. (PMID: 20300015) Arent S.M. … Greenwood J.C. (J Strength Cond Res 2010) 23 67
  5. Development and validation of a sensitive immunoassay for the skeletal muscle isoform of creatine kinase. (PMID: 18976957) Lo K.R. … Ingram J.R. (J Sci Med Sport 2010) 23 67

Products for CHKA Gene

Sources for CHKA Gene

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