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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CHKA Gene

protein-coding GIFtS: 61
GCID: GC11M067820

choline kinase alpha

(Previous name: choline kinase )
(Previous symbol: CHK)

Explore 109 diseases affiliated with
CHKA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Choline Kinase Alpha¹ ²		CK² ³
CHK¹ ² ³		EK² ³
CKI¹ ² ³		Choline Kinase¹
Ethanolamine Kinase² ³		EC 2.7.1.32³
CHETK-Alpha¹		EC 2.7.1.82³

External Ids:	HGNC: 1937¹	Entrez Gene: 1119²	Ensembl: ENSG00000110721⁷	OMIM: 118491⁵	UniProtKB: P35790³

Export aliases for CHKA gene to outside databases

Previous GC identifers: GC11M067596 GC11M067576 GC11M064155

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHKA:

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded

by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes

the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CHKA_HUMAN, P35790

Function: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step

in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and

ethanolamine. Has higher activity with choline

Gene Wiki entry for CHKA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CHKA gene promoter:
AP-1 ATF-2 NRSF form 1 c-Jun NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHKA promoter sequence

Search SABiosciences Chromatin IP Primers for CHKA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHKA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.1

CHKA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHKA gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M067820: view genomic region (about GC identifiers)

Start:	67,820,326 bp from pter	End:	67,888,858 bp from pter
Size:	68,533 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHKA_HUMAN, P35790 (See protein sequence)

Recommended Name: Choline kinase alpha

Size: 457 amino acids; 52249 Da

Subunit: Heterodimer with CHKB (By similarity). Homodimer

Subcellular location: Cytoplasm

6 PDB 3D structures from and Proteopedia for CHKA:

2CKO (3D)

2CKP (3D)

2CKQ (3D)

2I7Q (3D)

3F2R (3D)

3G15 (3D)

Secondary accessions: Q8NE29

Alternative splicing: 2 isoforms: P35790-1 P35790-2

Explore the universe of human proteins at neXtProt for CHKA: NX_P35790

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35790

CHKA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001268.2 NP_997634.1

ENSEMBL proteins:

ENSP00000265689 ENSP00000432631 ENSP00000348454 ENSP00000435032

Reactome Protein details: P35790
Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005829	cytosol	TAS	--

CHKA for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHKA for domains About GeneDecksing

2 InterPro domains/families:

IPR011009 Kinase-like_dom

IPR026712 Cho/Etha_kinase

Graphical View of Domain Structure for InterPro Entry P35790

ProtoNet protein and cluster: P35790

1 Blocks protein family: IPB002573 Choline/ethanolamine kinase

UniProtKB/Swiss-Prot: CHKA_HUMAN, P35790

Similarity: Belongs to the choline/ethanolamine kinase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CHKA_HUMAN, P35790

Function: Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step

in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and

ethanolamine. Has higher activity with choline

Catalytic activity: ATP + choline = ADP + phosphocholine

Catalytic activity: ATP + ethanolamine = ADP + O-phosphoethanolamine

Biophysicochemical properties: Kinetic parameters: KM=0.2 mM for choline; KM=0.4 mM for ATP; KM=12 mM for ethanolamine;

Enzyme Numbers (IUBMB): EC 2.7.1.32¹ EC 2.7.1.82¹

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CHKA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHKA
		8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate CHKA (see all 29):
		hsa-miR-30c hsa-miR-607 hsa-miR-199b-3p hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-200a hsa-miR-487a hsa-miR-485-3p

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHKA

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004103	choline kinase activity	IDA	19915674
GO:0004104	cholinesterase activity	IEA	--
GO:0004305	ethanolamine kinase activity	IDA	19915674
GO:0004871	signal transducer activity	TAS	10363580
GO:0005524	ATP binding	IEA	--

CHKA for ontologies About GeneDecksing

Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Chka):

homeostasis/metabolism

liver/biliary system

mortality/aging

CHKA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycerophospholipid biosynthesis

	Glycerophospholipid biosynthesis	1.00			Glycerophospholipid metabolism	0.54
	Phospholipid metabolism	0.64

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Synthesis of PE

Synthesis of PE

1.00

Synthesis of PC

0.30

Acetylcholine Synthesis

Acetylcholine Synthesis

1.00

choline biosynthesis III

phosphatidylcholine biosynthesis I

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for CHKA

	Acetylcholine Synthesis
	phosphatidylcholine biosynthesis I

5/6 Reactome Pathways for CHKA (see all 6)

	Glycerophospholipid biosynthesis
	Metabolism
	Phospholipid metabolism
	Synthesis of PE
	Synthesis of PC

2 Kegg Pathways (Kegg details for CHKA):

	Glycerophospholipid metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: CHKA_HUMAN, P35790

Pathway: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1

Pathway: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine:

step 1/3

CHKA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CHKA

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/10 Interacting proteins for CHKA (P35790³ ENSP00000265689⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FCHSD2	O94868³, ENSP00000386722⁴	I2D: score=1 STRING: ENSP00000386722
RCC1	P18754³, ENSP00000362937⁴	I2D: score=1 STRING: ENSP00000362937
ACHE	ENSP00000303211⁴	STRING: ENSP00000303211
CHAT	ENSP00000337103⁴	STRING: ENSP00000337103
PCYT1A	ENSP00000292823⁴	STRING: ENSP00000292823

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	10363580
GO:0006644	phospholipid metabolic process	TAS	--
GO:0006646	phosphatidylethanolamine biosynthetic process	TAS	--
GO:0006656	phosphatidylcholine biosynthetic process	TAS	--
GO:0006657	CDP-choline pathway	TAS	10363580

CHKA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CHKA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHKA

10/1079 HMDB Compounds for CHKA (see all 1079) About this table

Compound	Synonyms	CAS #	PubMed Ids
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Choline	(2-Hydroxyethyl)trimethyl ammonium (see all 19)	62-49-7	--
PC(14:0/14:0)	Phosphatidylcholine(14:0/14:0) (see all 8)	--	--
PC(14:0/14:1(9Z))	Phosphatidylcholine(14:0/14:1) (see all 14)	--	--
PC(14:0/15:0)	GPCho(14:0/15:0) (see all 8)	--	--
PC(14:0/16:0)	GPCho(30:0) (see all 8)	--	--
PC(14:0/16:1(9Z))	1-myristoyl-2-palmitoleoyl-sn-glycero-3-phosphocholine (see all 14)	--	--
PC(14:0/18:0)	1-myristoyl-2-stearoyl-sn-glycero-3-phosphocholine (see all 8)	--	--
PC(14:0/18:1(11Z))	Phosphatidylcholine(14:0/18:1w7) (see all 14)	--	--

1 DrugBank Compound for CHKA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Choline	Bilineurine (see all 7)	62-49-7	enzyme	substrate	16322253 16144842 17007874 17236204

10/80 Novoseek chemical compound relationships for CHKA gene (see all 80) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
creatinine	82.4	303	8732503 (3), 19112826 (3), 7882493 (2), 12849672 (2) (see all 99)
cyclocreatine	68.3	6	9277372 (2)
phosphocreatine	53.2	19	19112826 (2), 7739220 (2), 7882493 (1), 12849672 (1) (see all 11)
gemfibrozil	49.8	6	1492008 (2), 15900215 (1), 19934390 (1)
lipid	48.9	30	10734332 (2), 12607822 (2), 2175569 (1), 16178496 (1) (see all 27)
guanidinoacetate	46.3	5	17407807 (3), 16773469 (2)
aspartate	46	22	7976144 (1), 2089182 (1), 10920544 (1), 19317652 (1) (see all 22)
choline	45.5	35	11752077 (3), 10822168 (2), 16820874 (2), 18056454 (2) (see all 18)
phosphorylcholine	42.5	14	18056454 (4), 15003397 (2), 18172309 (1), 10363580 (1) (see all 5)
lovastatin	41.8	12	9322808 (3), 1492008 (2), 10999499 (1), 8725265 (1) (see all 6)

Search CenterWatch for drugs/clinical trials and news about CHKA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHKA gene (2 alternative transcripts):

NM_001277.2 NM_212469.1

Unigene Cluster for CHKA:

Choline kinase alpha

Hs.77221 [show with all ESTs]

Unigene Representative Sequence: AK054792

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000265689(uc001onj.3 uc001onk.3) ENST00000533728 ENST00000525155

ENST00000356135 ENST00000533910 ENST00000528235 ENST00000531341 ENST00000530730

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Additional cDNA sequence:

AK054792.1 AL834403.1 BC036471.2 D10704.1

17 DOTS entries:

DT.97816371 DT.87018001 DT.100749792 DT.441457 DT.95273279 DT.91665552 DT.100641700 DT.100773742

DT.91970788 DT.92402015 DT.120694515 DT.120694558 DT.86856215 DT.92449514 DT.95273276 DT.95303221

DT.95360346

24/156 AceView cDNA sequences (see all 156):

BU686771 NM_212469 BE857452 W76463 BQ708716 BG765406 AU131093 BQ637411

AA767660 BQ639677 BQ338888 BP369810 CB108651 NM_001277 CD358050 BQ674878

BF058897 CK430329 BF514960 AW016490 BI039685 AW592513 AV707021 BC036471

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CHKA (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13a	·	13b	·	13c	·	13d	^	14a	·	14b	·	14c	·	14d
SP1:					-																						-		-		-		-
SP2:					-		-																				-		-		-		-
SP3:
SP4:
SP5:																																	-

ECgene alternative splicing isoforms for CHKA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHKA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGTGGCCACG

About this image
See CHKA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHKA

SOURCE GeneReport for Unigene cluster: Hs.77221

SABiosciences Custom PCR Arrays for CHKA

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHKA gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CHKA¹	choline kinase alpha	75.37(n) 76.44(a)		423112 XM_421045.3 XP_421045.3
lizard (Anolis carolinensis)	Reptilia	CHKA⁶	--	77(a)	1 ↔ 1	1(75045835-75076842)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12834²	Xenopus laevis transcribed sequence with weak similarity more	78.32(n)		BJ073689.1
zebrafish (Danio rerio)	Actinopterygii	chka¹	choline kinase alpha	70.11(n) 70.67(a)		558499 NM_001044865.1 NP_001038330.1
fruit fly (Drosophila melanogaster)	Insecta	CG2201⁶	--	25(a)	1 → many	2L(21614232-21623627)
worm (Caenorhabditis elegans)	Secernentea	cka-2⁶ cka-1⁶ (see all 6)	Choline Kinase A family member (cka-1) (see all 6)	34(a) 29(a) (see all 6)	many ↔ many many ↔ many (see all 6)	X(4286713-4291466) IV(9731718-9737602)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATCK1⁶ AT1G74320⁶ (see all 3)	protein kinase domain-containing protein (see all 3)	30(a) 29(a) (see all 3)	many ↔ many many ↔ many (see all 3)	1(26971223-26973464) 1(27940673-27943204)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	phosphotransferase, putative, expressed (see all 3)	31(a) 29(a) (see all 3)	many ↔ many many ↔ many (see all 3)	1(4394154-4396000) 5(26521988-26525724)

ENSEMBL Gene Tree for CHKA (if available)
TreeFam Gene Tree for CHKA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CHKA gene

CHKB² ETNK1² CHKB-CPT1B² ETNK2²

2 SIMAP similar genes for CHKA using alignment to 3 protein entries: CHKA_HUMAN (see all proteins):

CHKB ETNK2

CHKA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs184625527^1,2		--	67819849(+)	`CTCGTA/GTGGAC`	2	--	ds500¹		0	--	--	--	--
rs187378930^1,2		--	67819969(+)	`ATTCAA/GTTTGG`	2	--	ds500¹		0	--	--	--	--
rs192708480^1,2		--	67820040(+)	`CCAGCC/TGCTCA`	2	--	ds500¹		0	--	--	--	--
rs113962336^1,2		--	67820067(+)	`GCACTG/TCTCCC`	2	--	ds500¹		1		CSA	2
rs138088391^1,2		--	67820141(+)	`GGGGAA/TGAAGA`	2	--	ds500¹		0	--	--	--	--
rs200345751^1,2		--	67820147(+)	`GAAGA-/GGA GGAGGTGGAGG`	2	--	ds500¹		0	--	--	--	--
rs184862396^1,2		--	67820258(+)	`CCTCCA/GTGGGC`	2	--	ds500¹		0	--	--	--	--
rs189324550^1,2		--	67820326(+)	`TGAGGC/TTGGGT`	2	--	ut3¹		0	--	--	--	--
rs11481^1,2	C,F,A,H,	--	67820335(-)	`AAAATT/AAAAAC`	2	--	ut3¹		14		EA NA WA CSA	422
rs118031971^1,2		--	67820400(+)	`TTCAAA/GTAAGA`	2	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for CHKA (67820326 - 67888858 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CHKA
2 CNVs: 2931 3856

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CHKA for disorders           About GeneDecksing

OMIM gene information: 118491    OMIM disorders: --

20/109 diseases for CHKA (see all 109):    About MalaCards

acyl-coa dehydrogenase bronchiolitis obliterans organizing pneumonia churg-strauss syndrome pseudohypoparathyroidism type ib

neuroleptic malignant syndrome focal segmental glomerulosclerosis creatine phosphokinase papillary serous carcinoma of the peritoneum

bronchiolitis obliterans myocardial infarction compartment syndrome duchenne muscular dystrophy

acute myocardial infarction muscular dystrophy spina bifida pseudohypoparathyroidism

orofacial cleft squamous cell carcinoma congenital muscular dystrophy carnitine deficiency

1 disease from the University of Copenhagen DISEASES database for CHKA:

Cancer

10/85 Novoseek disease relationships for CHKA gene (see all 85) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
rhabdomyolysis	67.6	12	1996798 (2), 7555662 (1), 8334797 (1), 8935369 (1) (see all 10)
myopathy	62.8	7	11388581 (1), 12766976 (1), 8725265 (1), 1470677 (1) (see all 6)
lipid storage myopathy	56.9	1	10723193 (1)
myositis	46.2	4	19934390 (2), 16102434 (1), 10084410 (1)
polymyositis	46	5	20459937 (3), 2265497 (1), 19498309 (1)
metastasis	43.1	13	11455556 (2), 18067640 (2), 15498190 (2), 15914276 (1) (see all 9)
crush syndrome	43.1	6	19317652 (3), 11172437 (1)
tumors	42.5	78	9208116 (4), 16355400 (3), 15938530 (3), 9704623 (2) (see all 43)
cancer	40.6	44	16820874 (2), 20522957 (2), 9988223 (1), 11752077 (1) (see all 28)
breast cancer	39.5	12	19417625 (2), 1696538 (1), 9704623 (1), 9828843 (1) (see all 10)

Human Genome Epidemiology (HuGE) Navigator: CHKA (5 documents)

Export disorders for CHKA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CHKA gene, integrated from 9 sources (see all 468):
(articles sorted by number of sources associating them with CHKA)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation. (PubMed id 1618328)^{1, 2, 3} Hosaka K.... Yamashita S. (1992)
Structure and function of choline kinase isoforms in mammalian cells. (PubMed id 15003397)^{1, 3, 9} Aoyama C....Ishidate K. (2004)
Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. (PubMed id 19915674)^{1, 2, 9} Gallego-Ortega D.... Lacal J.C. (2009)
Crystal structures of human choline kinase isoforms i n complex with hemicholinium-3: single amino acid near the active site influenc es inhibitor sensitivity. (PubMed id 20299452)^{1, 2} Hong B.S....Park H.W. (2010)
Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. (PubMed id 17007874)^{2, 7} Malito E.... Lavie A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Generation and characterization of monoclonal antibodies against choline kinase alpha and their potential use as diagnostic tools in cancer. (PubMed id 16820874)^{1, 9} Gallego-Ortega D....Lacal J.C. (2006)
A critical role for choline kinase-alpha in the aggre ssiveness of bladder carcinomas. (PubMed id 19448670)^{1, 9} Hernando E....RamA-rez de Molina A. (2009)
Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy. (PubMed id 18296102)^{1, 9} Ramirez de Molina A....Lacal J.C. (2008)
Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. (PubMed id 18172309)^{1, 9} Glunde K....Bhujwalla Z.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1119	HGNC: 1937	AceView: CHKA	Ensembl:ENSG00000110721	euGenes: HUgn1119
ECgene: CHKA	Kegg: 1119	H-InvDB: CHKA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CHKA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CHKA	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CHKA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CHKA gene:
Search GeneIP for patents involving CHKA

GeneCards and IP:
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choline kinase alpha

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Fatty Liver
Acute myocardial infarction
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aggressiveness
Hyperlipidemia
ADENOCARCINOMA LUNG
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OVARIAN CARCINOMA
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CHKA Gene

choline kinase alpha

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