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Aliases for CHID1 Gene

Aliases for CHID1 Gene

  • Chitinase Domain Containing 1 2 3 5
  • Stabilin-1-Interacting Chitinase-Like Protein 3 4
  • SI-CLP 3 4
  • Stabilin-1 Interacting Chitinase-Like Protein 3
  • GL008 3
  • SICLP 3

External Ids for CHID1 Gene

Previous GeneCards Identifiers for CHID1 Gene

  • GC11M000683

Summaries for CHID1 Gene

GeneCards Summary for CHID1 Gene

CHID1 (Chitinase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include hydrolase activity, hydrolyzing O-glycosyl compounds and chitinase activity.

UniProtKB/Swiss-Prot for CHID1 Gene

  • Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHID1 Gene

Genomics for CHID1 Gene

Regulatory Elements for CHID1 Gene

Promoters for CHID1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHID1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHID1 Gene

Chromosome:
11
Start:
867,859 bp from pter
End:
915,058 bp from pter
Size:
47,200 bases
Orientation:
Minus strand

Genomic View for CHID1 Gene

Genes around CHID1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHID1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHID1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHID1 Gene

Proteins for CHID1 Gene

  • Protein details for CHID1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BWS9-CHID1_HUMAN
    Recommended name:
    Chitinase domain-containing protein 1
    Protein Accession:
    Q9BWS9
    Secondary Accessions:
    • B3KWB0
    • Q8NBM9
    • Q96CZ3
    • Q96S93
    • Q96SK0
    • Q9BY52

    Protein attributes for CHID1 Gene

    Size:
    393 amino acids
    Molecular mass:
    44941 Da
    Quaternary structure:
    • Interacts with STAB1.

    Three dimensional structures from OCA and Proteopedia for CHID1 Gene

    Alternative splice isoforms for CHID1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHID1 Gene

Proteomics data for CHID1 Gene at MOPED

Post-translational modifications for CHID1 Gene

  • Ubiquitination at Lys 361
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for CHID1 Gene

Domains & Families for CHID1 Gene

Gene Families for CHID1 Gene

Protein Domains for CHID1 Gene

Suggested Antigen Peptide Sequences for CHID1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BWS9

UniProtKB/Swiss-Prot:

CHID1_HUMAN :
  • Belongs to the glycosyl hydrolase 18 family.
Family:
  • Belongs to the glycosyl hydrolase 18 family.
genes like me logo Genes that share domains with CHID1: view

Function for CHID1 Gene

Molecular function for CHID1 Gene

UniProtKB/Swiss-Prot Function:
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL4/interleukin-4 and dexamethasone in the macrophages. Up-regulated by glucocorticoid.

Gene Ontology (GO) - Molecular Function for CHID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16357325
genes like me logo Genes that share ontologies with CHID1: view
genes like me logo Genes that share phenotypes with CHID1: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHID1 Gene

Localization for CHID1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHID1 Gene

Secreted. Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHID1 Gene COMPARTMENTS Subcellular localization image for CHID1 gene
Compartment Confidence
endosome 5
extracellular 5
golgi apparatus 5
lysosome 5
nucleus 5
vacuole 5
cytoskeleton 2
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA 16357325
GO:0005802 trans-Golgi network IDA 16357325
genes like me logo Genes that share ontologies with CHID1: view

Pathways & Interactions for CHID1 Gene

SuperPathways for CHID1 Gene

No Data Available

Interacting Proteins for CHID1 Gene

Selected Interacting proteins: Q9BWS9-CHID1_HUMAN for CHID1 Gene via I2D

Symbol External ID(s) Details
STAB1

Gene Ontology (GO) - Biological Process for CHID1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006032 chitin catabolic process IEA,IBA --
genes like me logo Genes that share ontologies with CHID1: view

No data available for Pathways by source and SIGNOR curated interactions for CHID1 Gene

Drugs & Compounds for CHID1 Gene

No Compound Related Data Available

Transcripts for CHID1 Gene

Unigene Clusters for CHID1 Gene

Chitinase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHID1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9: -

Relevant External Links for CHID1 Gene

GeneLoc Exon Structure for
CHID1
ECgene alternative splicing isoforms for
CHID1

Expression for CHID1 Gene

mRNA expression in normal human tissues for CHID1 Gene

Protein differential expression in normal tissues from HIPED for CHID1 Gene

This gene is overexpressed in Spleen (8.5), Peripheral blood mononuclear cells (7.3), and Salivary gland (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CHID1 Gene



SOURCE GeneReport for Unigene cluster for CHID1 Gene Hs.144468

mRNA Expression by UniProt/SwissProt for CHID1 Gene

Q9BWS9-CHID1_HUMAN
Tissue specificity: Expressed in cells of monocytic, T, B and epithelial origin.
genes like me logo Genes that share expression patterns with CHID1: view

Protein tissue co-expression partners for CHID1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHID1 Gene

Orthologs for CHID1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHID1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHID1 36
  • 98 (a)
OneToOne
CHID1 35
  • 99.69 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia CHID1 35
  • 84.31 (n)
  • 82.7 (a)
CHID1 36
  • 57 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHID1 36
  • 90 (a)
OneToOne
CHID1 35
  • 87.7 (n)
  • 90.08 (a)
mouse
(Mus musculus)
Mammalia Chid1 16
Chid1 36
  • 89 (a)
OneToOne
Chid1 35
  • 86.77 (n)
  • 89.82 (a)
oppossum
(Monodelphis domestica)
Mammalia CHID1 36
  • 35 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHID1 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chid1 35
  • 87.53 (n)
  • 90.59 (a)
chicken
(Gallus gallus)
Aves CHID1 35
  • 66.33 (n)
  • 66.92 (a)
CHID1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHID1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chid1 35
  • 64.8 (n)
  • 63.36 (a)
zebrafish
(Danio rerio)
Actinopterygii chid1 36
  • 55 (a)
OneToOne
chid1 35
  • 57.72 (n)
  • 55.5 (a)
wufb02e07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008124 35
  • 52.47 (n)
  • 44.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8460 36
  • 39 (a)
OneToOne
CG8460 35
  • 51.79 (n)
  • 42.78 (a)
worm
(Caenorhabditis elegans)
Secernentea chil-10 36
  • 27 (a)
OneToMany
chil-14 36
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G01040 35
  • 49.95 (n)
  • 40.52 (a)
rice
(Oryza sativa)
Liliopsida Os01g0619800 35
  • 49.77 (n)
  • 42.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2914 36
  • 46 (a)
OneToOne
Species with no ortholog for CHID1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHID1 Gene

ENSEMBL:
Gene Tree for CHID1 (if available)
TreeFam:
Gene Tree for CHID1 (if available)

Paralogs for CHID1 Gene

genes like me logo Genes that share paralogs with CHID1: view

No data available for Paralogs for CHID1 Gene

Variants for CHID1 Gene

Sequence variations from dbSNP and Humsavar for CHID1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1127800 - 870,467(-) GCCCC(A/G)GATGG reference, missense
rs6682 - 870,446(+) CTGAG(A/C/G)CCTGG reference, missense
rs1127813 -- 882,455(-) gaggc(C/G)aaatt intron-variant, utr-variant-3-prime
rs3201761 -- 868,414(-) cctaa(A/G)aatag utr-variant-3-prime
rs3201764 -- 868,410(-) aaaat(A/G)gaaaa utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CHID1 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
dgv946n71 CNV Loss 21882294
essv11734 CNV CNV 17122850
nsv896599 CNV Loss 21882294
nsv832044 CNV Loss 17160897
nsv896636 CNV Loss 21882294
nsv896638 CNV Gain 21882294
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226
esv32950 CNV Gain 17666407
esv1667682 CNV Insertion 17803354
esv2743879 CNV Deletion 23290073
esv2743880 CNV Deletion 23290073
dgv332e1 CNV Complex 17122850
nsv428244 CNV Loss 18775914
essv22587 CNV CNV 17122850
esv2671662 CNV Deletion 23128226
nsv896639 CNV Loss 21882294
esv2663667 CNV Deletion 23128226

Variation tolerance for CHID1 Gene

Residual Variation Intolerance Score: 19.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHID1 Gene

HapMap Linkage Disequilibrium report
CHID1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHID1 Gene

Disorders for CHID1 Gene

Relevant External Links for CHID1

Genetic Association Database (GAD)
CHID1
Human Genome Epidemiology (HuGE) Navigator
CHID1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHID1

No disorders were found for CHID1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHID1 Gene

Publications for CHID1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. (PMID: 25241909) Lee J. … Silverman E.K. (Respir. Res. 2014) 3
  5. Human secreted stabilin-1-interacting chitinase-like protein aggravates the inflammation associated with rheumatoid arthritis and is a potential macrophage inflammatory regulator in rodents. (PMID: 24470346) Xiao W. … Zheng X. ( 2014) 3

Products for CHID1 Gene

Sources for CHID1 Gene

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