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Aliases for CHIC2 Gene

Aliases for CHIC2 Gene

  • Cysteine-Rich Hydrophobic Domain 2 2 3
  • BTL 3 4
  • Cysteine-Rich Hydrophobic Domain 2 Protein 3
  • BRX-Like Translocated In Leukemia 3
  • Cystein-Rich Hydrophobic Domain 2 3
  • BrX-Like Translocated In Leukemia 4

External Ids for CHIC2 Gene

Previous GeneCards Identifiers for CHIC2 Gene

  • GC04M054686
  • GC04M054845
  • GC04M054725
  • GC04M054791
  • GC04M054716
  • GC04M054570
  • GC04M054875
  • GC04M050822

Summaries for CHIC2 Gene

Entrez Gene Summary for CHIC2 Gene

  • This gene encodes a member of the CHIC family of proteins. The encoded protein contains a cysteine-rich hydrophobic (CHIC) motif, and is localized to vesicular structures and the plasma membrane. This gene is associated with some cases of acute myeloid leukemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHIC2 Gene

CHIC2 (Cysteine-Rich Hydrophobic Domain 2) is a Protein Coding gene. Diseases associated with CHIC2 include leukemia, acute myeloid and calcific tendinitis. An important paralog of this gene is CHIC1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHIC2 Gene

Genomics for CHIC2 Gene

Regulatory Elements for CHIC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHIC2 Gene

54,008,373 bp from pter
54,065,427 bp from pter
57,055 bases
Minus strand

Genomic View for CHIC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHIC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHIC2 Gene

Proteins for CHIC2 Gene

  • Protein details for CHIC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cysteine-rich hydrophobic domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R639

    Protein attributes for CHIC2 Gene

    165 amino acids
    Molecular mass:
    19254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHIC2 Gene

Proteomics data for CHIC2 Gene at MOPED

Post-translational modifications for CHIC2 Gene

  • Palmitoylation in the CHIC motif is required for membrane association.
  • Ubiquitination at Lys 77 and Lys 117
  • Modification sites at PhosphoSitePlus

Other Protein References for CHIC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHIC2 Gene

Domains & Families for CHIC2 Gene

Protein Domains for CHIC2 Gene


Suggested Antigen Peptide Sequences for CHIC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CHIC family.
  • Belongs to the CHIC family.
genes like me logo Genes that share domains with CHIC2: view

No data available for Gene Families for CHIC2 Gene

Function for CHIC2 Gene

Gene Ontology (GO) - Molecular Function for CHIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with CHIC2: view

Phenotypes for CHIC2 Gene

GenomeRNAi human phenotypes for CHIC2:
genes like me logo Genes that share phenotypes with CHIC2: view

Animal Model Products

miRNA for CHIC2 Gene

miRTarBase miRNAs that target CHIC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CHIC2 Gene

Localization for CHIC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHIC2 Gene

Cell membrane. Cytoplasmic vesicle. Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles.

Subcellular locations from

Jensen Localization Image for CHIC2 Gene COMPARTMENTS Subcellular localization image for CHIC2 gene
Compartment Confidence
golgi apparatus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for CHIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular IBA --
GO:0005794 Golgi apparatus --
GO:0005798 Golgi-associated vesicle IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with CHIC2: view

Pathways & Interactions for CHIC2 Gene

SuperPathways for CHIC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHIC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006893 Golgi to plasma membrane transport IBA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with CHIC2: view

No data available for Pathways by source and SIGNOR curated interactions for CHIC2 Gene

Drugs & Compounds for CHIC2 Gene

No Compound Related Data Available

Transcripts for CHIC2 Gene

Unigene Clusters for CHIC2 Gene

Cysteine-rich hydrophobic domain 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHIC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHIC2 Gene

No ASD Table

Relevant External Links for CHIC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHIC2 Gene

mRNA expression in normal human tissues for CHIC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHIC2 Gene

This gene is overexpressed in Whole Blood (x6.1).

Protein differential expression in normal tissues from HIPED for CHIC2 Gene

This gene is overexpressed in Placenta (32.1), CD4 Tcells (11.3), Retina (7.4), and Liver (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHIC2 Gene

SOURCE GeneReport for Unigene cluster for CHIC2 Gene Hs.335393

genes like me logo Genes that share expression patterns with CHIC2: view

Protein tissue co-expression partners for CHIC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHIC2 Gene

Orthologs for CHIC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHIC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHIC2 36
  • 100 (a)
CHIC2 35
  • 99.6 (n)
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia CHIC2 36
  • 81 (a)
(Mus musculus)
Mammalia Chic2 36
  • 99 (a)
Chic2 16
Chic2 35
  • 95.96 (n)
  • 99.39 (a)
(Monodelphis domestica)
Mammalia CHIC2 36
  • 100 (a)
(Canis familiaris)
Mammalia CHIC2 36
  • 91 (a)
CHIC2 35
  • 99.47 (n)
  • 100 (a)
(Bos Taurus)
Mammalia CHIC2 36
  • 100 (a)
CHIC2 35
  • 97.98 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Chic2 35
  • 95.76 (n)
  • 99.39 (a)
(Gallus gallus)
Aves CHIC2 36
  • 99 (a)
CHIC2 35
  • 92.32 (n)
  • 98.79 (a)
(Anolis carolinensis)
Reptilia CHIC2 36
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.32435 35
tropical clawed frog
(Silurana tropicalis)
Amphibia chic2 35
  • 87.47 (n)
  • 94.55 (a)
(Danio rerio)
Actinopterygii chic2 36
  • 90 (a)
zgc55670 35
chic2 35
  • 78.62 (n)
  • 93.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5938 36
  • 63 (a)
CG5938 35
  • 62.8 (n)
  • 69.57 (a)
CG5938 37
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001278 35
  • 61.01 (n)
  • 67.88 (a)
(Caenorhabditis elegans)
Secernentea tag-266 36
  • 44 (a)
Species with no ortholog for CHIC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHIC2 Gene

Gene Tree for CHIC2 (if available)
Gene Tree for CHIC2 (if available)

Paralogs for CHIC2 Gene

Paralogs for CHIC2 Gene

(1) SIMAP similar genes for CHIC2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHIC2: view

Variants for CHIC2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CHIC2 Gene

Variant ID Type Subtype PubMed ID
nsv879018 CNV Loss 21882294
nsv879019 CNV Loss 21882294

Variation tolerance for CHIC2 Gene

Residual Variation Intolerance Score: 43.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHIC2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for CHIC2 Gene

Disorders for CHIC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CHIC2 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
calcific tendinitis
- elite association
Search CHIC2 in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving CHIC2 is found in a form of acute myeloid leukemia (AML). Translocation t(4;12)(q12;p13) with ETV6.

Relevant External Links for CHIC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CHIC2: view

No data available for Genatlas for CHIC2 Gene

Publications for CHIC2 Gene

  1. Characterization of the amplicon on chromosomal segment 4q12 in glioblastoma multiforme. (PMID: 17504929) Holtkamp N. … von Deimling A. (Neuro-oncology 2007) 23 67
  2. A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. (PMID: 11257495) Cools J. … Marynen P. (FEBS Lett. 2001) 23 67
  3. A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation. (PMID: 10706884) Iijima Y. … Sato Y. (Blood 2000) 23 67
  4. Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). (PMID: 10477709) Cools J. … Marynen P. (Blood 1999) 2 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for CHIC2 Gene

Sources for CHIC2 Gene

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