CHIC1 Gene
protein-coding GIFtS: 41
GCID: GC0XP072782
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cysteine-rich hydrophobic domain 1
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Aliases
for CHIC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cysteine-Rich Hydrophobic Domain 11 2 | | BRX1 2 3 | | Brain X-Linked Protein2 3 | | Cystein-Rich Hydrophobic Domain 12 | | Cysteine-Rich Hydrophobic Domain 1 Protein2 |
Export aliases for CHIC1 gene to outside databasesPrevious GC identifers: GC0XP068596 GC0XP069957 GC0XU900457 GC0XP072566 GC0XP072699 GC0XP066415 |
Summaries
for CHIC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CHIC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHIC1 gene promoter:
POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) Nkx2-5 POU3F2 Gfi-1 HNF-1A N-Myc FAC1 HNF-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHIC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHIC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.2 Ensembl cytogenetic band: Xq13.2 HGNC cytogenetic band: Xq13.2CHIC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP072782: view genomic region
(about GC identifiers)
Start:
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72,782,984 bp from pter |
End:
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72,906,937 bp from pter |
Size:
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123,954 bases |
Orientation:
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plus strand |
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Proteins
for CHIC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHIC1_HUMAN, Q5VXU3 (See
protein sequence)Recommended Name: Cysteine-rich hydrophobic domain 1 protein Size: 224 amino acids; 25616 Da
Subcellular location: Cell membrane (By similarity). Cytoplasmic vesicle (By similarity). Note=Also present at aGolgi-like vesicular compartment and at scattered vesicles (By similarity)
Caution: It is uncertain whether Met-1 or Met-8 is the initiator
Secondary accessions: A0PJZ2 B0QZ87 B9EGS5 Q5CZ84Alternative splicing: 2 isoforms: Q5VXU3-1 Q5VXU3-2 Explore the universe of human proteins at neXtProt for CHIC1: NX_Q5VXU3
Post-translational modifications:
Palmitoylated (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VXU3
CHIC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001034929.2
ENSEMBL proteins: ENSP00000362601 ENSP00000432985 ENSP00000362603
Human Recombinant Protein Products for CHIC1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016023 | cytoplasmic membrane-bounded vesicle |
IEA | -- |
CHIC1 for ontologies About GeneDecksing
CHIC1 Antibody Products:
Assay Products for CHIC1: |
Protein
Domains /
Families
for CHIC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHIC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q5VXU3ProtoNet protein and cluster: Q5VXU3 UniProtKB/Swiss-Prot: CHIC1_HUMAN, Q5VXU3Similarity: Belongs to the CHIC family |
Function
for CHIC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Chic1):
CHIC1 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHIC1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHIC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHIC1 (NM_001039840) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHIC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHIC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHIC1 |
|
Pathways & Interactions
for CHIC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHIC1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for CHIC1 (ENSP000003626014) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for CHIC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CHIC1
Search CenterWatch for drugs/clinical trials and news about CHIC1
|
Transcripts
for CHIC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHIC1 gene: NM_001039840.2 Unigene Cluster for CHIC1: Cysteine-rich hydrophobic domain 1 Hs.496323 [show with all ESTs]Unigene Representative Sequence: NM_0010398404 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373502(uc004ebk.4 uc010nlo.3 uc004ebl.4 uc011mql.2)
ENST00000498407 ENST00000498318 ENST00000373504
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHIC1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHIC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHIC1 (NM_001039840) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHIC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHIC1 |
Additional cDNA sequence: AK057786.1 AK295903.1 AK297768.1 AL832095.1 BC050300.1 BC127727.1 BC127728.1 BC136691.1 BC136692.1 CR627010.1 CR936642.1 Y11897.1 5 DOTS entries: DT.121295095 DT.109408 DT.100748111 DT.121295072 DT.91907317 24/46 AceView cDNA sequences (see all 46): AA581996 AI580377 CR627010 CB044853 AI017400 BC050300 AI745136 BU166259 BU520824 AA918471 AW268816 AA305080 BG113485 N90842 BU952692 CB044854 CA867185 BI439741 Y11897 BI670507 BF038278 BE893831 AW083224 AI801579
GeneLoc Exon Structure
|
Expression
for CHIC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHIC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATCTTGCAT
About this image
See CHIC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHIC1
SOURCE GeneReport for Unigene cluster: Hs.496323
UniProtKB/Swiss-Prot: CHIC1_HUMAN, Q5VXU3Tissue specificity: Equally expressed in various parts of the brain
SABiosciences Custom PCR Arrays for CHIC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHIC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHIC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHIC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHIC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHIC1 |
Orthologs
for CHIC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHIC1 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for CHIC1 (if available)
TreeFam Gene Tree for CHIC1 (if available) |
Paralogs
for CHIC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHIC1 gene
- CHIC22
1 SIMAP similar gene for CHIC1 using alignment to 2 protein entries: CHIC1_HUMAN (see all proteins):CHIC2
CHIC1 for paralogs About GeneDecksing
|
Genomic Variants
for CHIC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHIC1 (72782984 - 72906937 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for CHIC1
6 CNVs: 83596 96763 96764 103258 67991 37058
1 Indel: 83597 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHIC1 |
|
Disorders
/ Diseases
for CHIC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHIC1 for disorders About GeneDecksing
2  diseases for CHIC1: About MalaCardsleukemia lymphoid leukemia
Export disorders for CHIC1 gene to outside databases
|
Publications
for CHIC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHIC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CHIC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. (PubMed id 9321471)1, 2, 3 Simmler M.-C....Avner P. (1997)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. (PubMed id 11257495)1, 3 Cools J.... Marynen P. (2001)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CHIC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHIC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHIC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHIC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHIC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CHIC1 gene:
Search GeneIP for patents involving CHIC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHIC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHIC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHIC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHIC1 | | | OriGene Protein Over-expression Lysate for CHIC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHIC1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHIC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHIC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHIC1 | | OriGene Custom Protein Services for CHIC1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHIC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHIC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHIC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHIC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHIC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHIC1 |
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 |  |  |  | |
| | | | Search Tocris compounds for CHIC1 |
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 | | | CHIC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHIC1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CHIC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHIC1 |
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