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CHIC1 Gene

protein-coding   GIFtS: 41
GCID: GC0XP072782

Cysteine-Rich Hydrophobic Domain 1

  Search for CHIC1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cysteine-Rich Hydrophobic Domain 11 2
Brain X-Linked Protein2 3
BRX2 3
Cystein-Rich Hydrophobic Domain 12
Cysteine-Rich Hydrophobic Domain 1 Protein2

External Ids:    HGNC: 19341   Entrez Gene: 533442   Ensembl: ENSG000002041167   UniProtKB: Q5VXU33   

Export aliases for CHIC1 gene to outside databases

Previous GC identifers: GC0XP068596 GC0XP069957 GC0XU900457 GC0XP072566 GC0XP072699 GC0XP066415


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CHIC1 Gene:
CHIC1 (cysteine-rich hydrophobic domain 1) is a protein-coding gene. An important paralog of this gene is CHIC2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHIC1 gene promoter:
         POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   Gfi-1   HNF-1A   N-Myc   FAC1   HNF-1   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CHIC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHIC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2   Ensembl cytogenetic band:  Xq13.2   HGNC cytogenetic band: Xq13.2

CHIC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHIC1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP072782:  view genomic region     (about GC identifiers)

Start:
72,782,984 bp from pter      End:
72,906,937 bp from pter
Size:
123,954 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHIC1_HUMAN, Q5VXU3 (See protein sequence)
Recommended Name: Cysteine-rich hydrophobic domain 1 protein  
Size: 224 amino acids; 25616 Da
Caution: It is uncertain whether Met-1 or Met-8 is the initiator
Secondary accessions: A0PJZ2 B0QZ87 B9EGS5 Q5CZ84
Alternative splicing: 2 isoforms:  Q5VXU3-1   Q5VXU3-2   

Explore the universe of human proteins at neXtProt for CHIC1: NX_Q5VXU3

Explore proteomics data for CHIC1 at MOPED

Post-translational modifications: 

  • Palmitoylated (By similarity)1
  • Ubiquitination2 at Lys176
  • Modification sites at PhosphoSitePlus

  • See CHIC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001034929.2  
    ENSEMBL proteins: 
     ENSP00000362603   ENSP00000362601   ENSP00000432985   ENSP00000473482  

    CHIC1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CHIC1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CHIC1
    GenScript Custom Purified and Recombinant Proteins Services for CHIC1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHIC1

     
    Search eBioscience for Proteins for CHIC1 

    CHIC1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHIC1
    Novus Biologicals CHIC1 Antibody
    Search for Antibodies for CHIC1 at Abcam
    Cloud-Clone Corp. Antibodies for CHIC1
    Search ThermoFisher Antibodies for CHIC1
    LSBio Antibodies in human, mouse, rat for CHIC1

    CHIC1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHIC1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHIC1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHIC1
    Cloud-Clone Corp. CLIAs for CHIC1
    Search eBioscience for ELISAs for CHIC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019383 Golgin_A_7/ERF4

    Graphical View of Domain Structure for InterPro Entry Q5VXU3

    ProtoNet protein and cluster: Q5VXU3

    UniProtKB/Swiss-Prot: CHIC1_HUMAN, Q5VXU3
    Similarity: Belongs to the CHIC family


    Find genes that share domains with CHIC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Chic1):
     normal 

    Find genes that share phenotypes with CHIC1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHIC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHIC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHIC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHIC1

    miRNA
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    Block miRNA regulation of human, mouse, rat CHIC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHIC1 (see all 168):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-106a hsa-miR-128 hsa-miR-134 hsa-miR-519a hsa-miR-3916 hsa-miR-3622b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHIC1
    Predesigned siRNA for gene silencing in human, mouse, rat CHIC1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHIC1

    Clone
    Products:
         
    OriGene clones in human, mouse for CHIC1 (see all 6)
    OriGene ORF clones in mouse, rat for CHIC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHIC1 (NM_001039840)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHIC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHIC1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CHIC1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHIC1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHIC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHIC1_HUMAN, Q5VXU3: Cell membrane (By similarity). Cytoplasmic vesicle (By similarity). Note=Also present at a
    Golgi-like vesicular compartment and at scattered vesicles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    plasma membrane2
    endoplasmic reticulum1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IEA--

    Find genes that share ontologies with CHIC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHIC1
    Interactions:

        Search GeneGlobe Interaction Network for CHIC1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for CHIC1 (ENSP000003626014) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHIC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHIC1 gene: 
    NM_001039840.2  

    Unigene Cluster for CHIC1:

    Cysteine-rich hydrophobic domain 1
    Hs.496323  [show with all ESTs]
    Unigene Representative Sequence: NM_001039840
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373504 ENST00000373502(uc004ebk.4 uc010nlo.3 uc004ebl.4 uc011mql.2)
    ENST00000498407 ENST00000498318
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHIC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHIC1 (see all 168):
    hsa-miR-411* hsa-miR-576-3p hsa-miR-106a hsa-miR-128 hsa-miR-134 hsa-miR-519a hsa-miR-3916 hsa-miR-3622b-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHIC1
    Predesigned siRNA for gene silencing in human, mouse, rat CHIC1
    Clone
    Products:
         
    OriGene clones in human, mouse for CHIC1 (see all 6)
    OriGene ORF clones in mouse, rat for CHIC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHIC1 (NM_001039840)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHIC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHIC1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CHIC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHIC1
      QuantiTect SYBR Green Assays in human, mouse, rat CHIC1
      QuantiFast Probe-based Assays in human, mouse, rat CHIC1

    Additional mRNA sequence: 

    AK057786.1 AK295903.1 AK297768.1 AL832095.1 BC050300.1 BC127727.1 BC127728.1 BC136691.1 
    BC136692.1 CR627010.1 CR936642.1 Y11897.1 

    5 DOTS entries:

    DT.121295095  DT.109408  DT.100748111  DT.121295072  DT.91907317 

    Selected AceView cDNA sequences (see all 46):

    BC050300 BU166259 AI017400 BU520824 AA918471 CB044853 AI580377 AA581996 
    CR627010 AI745136 AW268816 AL832095 BX508030 N90842 CB044854 Y11897 
    AA062610 AI801579 BU952692 AV700331 AA305080 BI439741 BI670507 BI918113 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHIC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTTGCAT
    CHIC1 Expression
    About this image

    CHIC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHIC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.496323

    UniProtKB/Swiss-Prot: CHIC1_HUMAN, Q5VXU3
    Tissue specificity: Equally expressed in various parts of the brain

        Custom PCR Arrays for CHIC1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CHIC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHIC1
    QuantiTect SYBR Green Assays in human, mouse, rat CHIC1
    QuantiFast Probe-based Assays in human, mouse, rat CHIC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHIC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHIC1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chic11 , 5 cysteine-rich hydrophobic domain 11, 5 89.99(n)1
    94.17(a)1
      X (46.08 cM)5
    122121  NM_009767.21  NP_033897.11 
     1033564765 
    chicken
    (Gallus gallus)
    Aves CHIC11 cysteine-rich hydrophobic domain 1 83.42(n)
    86.63(a)
      422318  NM_001031122.1  NP_001026293.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHIC16
    cysteine-rich hydrophobic domain 1
    78(a)
    1 ↔ 1
    GL343735.1(233241-245329)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1017326171 cysteine-rich hydrophobic domain 1 protein-like 78.62(n)
    82.07(a)
      101732617  XM_004916833.1  XP_004916890.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chic11 cysteine-rich hydrophobic domain 1 77.48(n)
    90.73(a)
      564524  NM_001201463.1  NP_001188392.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG59383   -- 58(a)   97F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2661 tag-266 51.93(n)
    49.28(a)
      175219  NM_064826.3  NP_497227.1 


    ENSEMBL Gene Tree for CHIC1 (if available)
    TreeFam Gene Tree for CHIC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHIC1 gene
    CHIC22  
    1 SIMAP similar gene for CHIC1 using alignment to 3 protein entries:     CHIC1_HUMAN (see all proteins):
    CHIC2

    Find genes that share paralogs with CHIC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHIC1 (see all 1486)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24867801,2
    H--72784976(+) CACGGT/GTTTAC 1 -- int14Minor allele frequency- G:0.00NS EA 418
    rs1891545451,2
    --72785459(+) AATGTC/TTTGGG 1 -- int10--------
    rs1814911101,2
    --72785585(+) AATCTC/TATTCT 1 -- int10--------
    rs120101561,2
    C,F,H--72785630(+) TTTCTG/CGCATA 1 -- int15Minor allele frequency- C:0.14NS EA NA 420
    rs1856906751,2
    --72785636(+) GCATAC/GGAGTG 1 -- int10--------
    rs1494055691,2
    --72785794(+) TCAAAC/GTCAGT 1 -- int10--------
    rs1905363811,2
    --72786501(+) GTTTTC/GTCTTT 1 -- int10--------
    rs1447660301,2
    --72786513(+) CCCCTA/CTCTGA 1 -- int10--------
    rs1810489941,2
    C--72786703(+) ACAGGA/CCTTCA 1 -- int10--------
    rs1860398261,2
    --72786729(+) ACAGAA/GAATAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for CHIC1 (72782984 - 72906937 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CHIC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2490652CNV Deletion19546169
    nsv515213CNV Loss21397061
    nsv6958CNV Loss18451855
    nsv499728CNV Loss21111241
    esv23979CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHIC1
    DNA2.0 Custom Variant and Variant Library Synthesis for CHIC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHIC1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with CHIC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. (PubMed id 9321471)1, 2, 3 Simmler M.-C....Avner P. (Mamm. Genome 1997)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. (PubMed id 11257495)1, 3 Cools J.... Marynen P. (FEBS Lett. 2001)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53344 HGNC: 1934 AceView: CHIC1 Ensembl:ENSG00000204116 euGenes: HUgn53344
    ECgene: CHIC1 H-InvDB: CHIC1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHIC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHIC1 gene:
    Search GeneIP for patents involving CHIC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHIC1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CHIC1  
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     OriGene Custom Antibody Services for CHIC1   OriGene Custom Protein Services for CHIC1  

     
     
     Block miRNA regulation of human, mouse, rat CHIC1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CHIC1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHIC1 Predesigned siRNA for gene silencing in human, mouse, rat CHIC1
     QuantiFast Probe-based Assays in human, mouse, rat CHIC1 QuantiTect SYBR Green Assays in human, mouse, rat CHIC1
     Custom PCR Arrays for CHIC1 Search Chromatin IP Primers for CHIC1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHIC1  Search GeneGlobe Interaction Network for CHIC1
     Regulatory tfbs in CHIC1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CHIC1 GenScript cDNA clones with any tag delivered in your preferred vector for CHIC1
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
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     Search Tocris compounds for CHIC1
     Browse Sino Biological Proteins
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Search for Antibodies for CHIC1 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CHIC1
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     Proteins for CHIC1
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     CLIAs for CHIC1



     Browse ESI BIO Cell Lines and PureStem Progenitors for CHIC1
     Gene Synthesis
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for CHIC1
     Browse SwitchGear Promoter luciferase reporter plasmids for CHIC1
     Search ThermoFisher Antibodies for CHIC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHIC1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHIC1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHIC1
     LSBio Antibodies in human, mouse, rat for CHIC1
    Customized transgenic rodents for:
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     Browse compounds at ApexBio
     Search Addgene for plasmids for CHIC1
      Search eBioscience for proteins for CHIC1
      Search eBioscience for elisas for CHIC1
      eBioscience FlowRNA Probe Sets
           
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