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Aliases for CHIC1 Gene

Aliases for CHIC1 Gene

  • Cysteine Rich Hydrophobic Domain 1 2 3 5
  • Brain X-Linked Protein 3 4
  • BRX 3 4
  • Cysteine-Rich Hydrophobic Domain-Containing Protein 1 3
  • Cysteine-Rich Hydrophobic Domain 1 2

External Ids for CHIC1 Gene

Previous GeneCards Identifiers for CHIC1 Gene

  • GC0XP068596
  • GC0XP069957
  • GC0XU900457
  • GC0XP072566
  • GC0XP072699
  • GC0XP072782
  • GC0XP066415

Summaries for CHIC1 Gene

Entrez Gene Summary for CHIC1 Gene

  • This gene encodes a cysteine-rich hydrophobic (CHIC) domain-containing protein, and is one of the few protein-coding genes found near the X-inactivation center. Studies in mouse indicate that the mouse ortholog of this gene is subject to X-inactivation in mouse. Experiments with other CHIC domain-containing family members show that the cysteine residues are palmitoylated post-translationally, resulting in membrane association. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

GeneCards Summary for CHIC1 Gene

CHIC1 (Cysteine Rich Hydrophobic Domain 1) is a Protein Coding gene. An important paralog of this gene is CHIC2.

Additional gene information for CHIC1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHIC1 Gene

Genomics for CHIC1 Gene

Regulatory Elements for CHIC1 Gene

Enhancers for CHIC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH073943 1.2 ENCODE 45.6 +381.4 381392 2.2 MLX FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZC3H11A FTX ENSG00000271199 RAB11FIP1P1 JPX DDX3P1 RN7SL648P CHIC1 ENSG00000228906 TOMM20P4 ENSG00000271533
GH0XH072713 1 ENCODE 21.9 -848.7 -848705 2.6 ATF1 ARNT SIN3A GLI4 ZNF2 GLIS2 ZNF548 SP3 SP5 TSHZ1 RTL5 CHIC1 HDAC8 PHKA1 ENSG00000273788 GC0XM072728
GH0XH073850 1.1 ENCODE 12.2 +288.5 288527 2.3 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF302 ZNF143 ZNF548 RAB11FIP1P1 JPX ENSG00000271199 RN7SL648P FTX DDX3P1 ENSG00000234969 ENSG00000271533 MKRN5P TOMM20P4
GH0XH074449 1 Ensembl ENCODE 12.2 +887.8 887825 2.9 ZSCAN26 NFIB MAX ZNF195 FEZF1 ZIC2 ZNF664 GATA3 SCRT2 ZNF19 ENSG00000271199 ENSG00000234969 MKRN5P SLC16A2 CHIC1 ENSG00000271533 GC0XM074453
GH0XH073576 0.6 ENCODE 8.2 +14.3 14307 2 RFX1 JUN CEBPB BMI1 EP300 RFX5 JUND MAFK TCF7L2 CHIC1 FAM226B NAP1L6 PIR39676
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHIC1 on UCSC Golden Path with GeneCards custom track

Promoters for CHIC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247235 352 2200 HDGF GLI4 ZNF2 YY1 ZNF207 SP3 YY2 SREBF1 SMARCA4 NBN

Genomic Locations for CHIC1 Gene

Genomic Locations for CHIC1 Gene
chrX:73,563,148-73,687,109
(GRCh38/hg38)
Size:
123,962 bases
Orientation:
Plus strand
chrX:72,782,984-72,906,937
(GRCh37/hg19)

Genomic View for CHIC1 Gene

Genes around CHIC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHIC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHIC1 Gene

Proteins for CHIC1 Gene

  • Protein details for CHIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXU3-CHIC1_HUMAN
    Recommended name:
    Cysteine-rich hydrophobic domain-containing protein 1
    Protein Accession:
    Q5VXU3
    Secondary Accessions:
    • A0PJZ2
    • B0QZ87
    • B9EGS5
    • Q5CZ84

    Protein attributes for CHIC1 Gene

    Size:
    224 amino acids
    Molecular mass:
    25616 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CHIC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHIC1 Gene

Post-translational modifications for CHIC1 Gene

No data available for DME Specific Peptides for CHIC1 Gene

Domains & Families for CHIC1 Gene

Gene Families for CHIC1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CHIC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHIC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VXU3

UniProtKB/Swiss-Prot:

CHIC1_HUMAN :
  • Belongs to the CHIC family.
Family:
  • Belongs to the CHIC family.
genes like me logo Genes that share domains with CHIC1: view

Function for CHIC1 Gene

Phenotypes for CHIC1 Gene

genes like me logo Genes that share phenotypes with CHIC1: view

miRNA for CHIC1 Gene

miRTarBase miRNAs that target CHIC1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHIC1 Gene

Localization for CHIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHIC1 Gene

Cell membrane. Cytoplasmic vesicle. Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHIC1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CHIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with CHIC1: view

Pathways & Interactions for CHIC1 Gene

SuperPathways for CHIC1 Gene

No Data Available

Interacting Proteins for CHIC1 Gene

Gene Ontology (GO) - Biological Process for CHIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
genes like me logo Genes that share ontologies with CHIC1: view

No data available for Pathways by source and SIGNOR curated interactions for CHIC1 Gene

Drugs & Compounds for CHIC1 Gene

No Compound Related Data Available

Transcripts for CHIC1 Gene

Unigene Clusters for CHIC1 Gene

Cysteine-rich hydrophobic domain 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHIC1 Gene

No ASD Table

Relevant External Links for CHIC1 Gene

GeneLoc Exon Structure for
CHIC1
ECgene alternative splicing isoforms for
CHIC1

Expression for CHIC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHIC1 Gene

Protein differential expression in normal tissues from HIPED for CHIC1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHIC1 Gene



Protein tissue co-expression partners for CHIC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHIC1 Gene:

CHIC1

SOURCE GeneReport for Unigene cluster for CHIC1 Gene:

Hs.496323

mRNA Expression by UniProt/SwissProt for CHIC1 Gene:

Q5VXU3-CHIC1_HUMAN
Tissue specificity: Equally expressed in various parts of the brain.

Evidence on tissue expression from TISSUES for CHIC1 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CHIC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHIC1 Gene

Orthologs for CHIC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHIC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHIC1 33 34
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia CHIC1 33 34
  • 93.9 (n)
dog
(Canis familiaris)
Mammalia CHIC1 33 34
  • 93.7 (n)
mouse
(Mus musculus)
Mammalia Chic1 33 16 34
  • 89.99 (n)
rat
(Rattus norvegicus)
Mammalia Chic1 33
  • 89.88 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves CHIC1 33 34
  • 83.42 (n)
lizard
(Anolis carolinensis)
Reptilia CHIC1 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732617 33
  • 78.62 (n)
zebrafish
(Danio rerio)
Actinopterygii chic1 33 34
  • 77.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5938 35 34
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea tag-266 33 34
  • 51.93 (n)
Species where no ortholog for CHIC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHIC1 Gene

ENSEMBL:
Gene Tree for CHIC1 (if available)
TreeFam:
Gene Tree for CHIC1 (if available)

Paralogs for CHIC1 Gene

Paralogs for CHIC1 Gene

(1) SIMAP similar genes for CHIC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHIC1: view

Variants for CHIC1 Gene

Sequence variations from dbSNP and Humsavar for CHIC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs864622038 Uncertain significance 73,577,441(+) AATTT(C/T)CCTCC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000030205 -- 73,593,787(+) TATGG(G/T)CATTT intron-variant
rs1000032735 -- 73,620,975(+) TGCTT(A/G)TTTTT intron-variant
rs1000061785 -- 73,686,731(+) GAACA(A/G)GATAT utr-variant-3-prime
rs1000092527 -- 73,581,847(+) GTAAT(-/G)TTTTT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CHIC1 Gene

Variant ID Type Subtype PubMed ID
nsv6958 CNV deletion 18451855
nsv515213 CNV loss 21397061
nsv499728 CNV loss 21111241
esv2490652 CNV deletion 19546169
esv23979 CNV loss 19812545

Variation tolerance for CHIC1 Gene

Gene Damage Index Score: 0.12; 2.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHIC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHIC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHIC1 Gene

Disorders for CHIC1 Gene

Relevant External Links for CHIC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHIC1

No disorders were found for CHIC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHIC1 Gene

Publications for CHIC1 Gene

  1. Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. (PMID: 9321471) Simmler MC … Avner P (Mammalian genome : official journal of the International Mammalian Genome Society 1997) 2 3 4 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. (PMID: 11257495) Cools J … Marynen P (FEBS letters 2001) 2 3 60
  5. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60

Products for CHIC1 Gene

Sources for CHIC1 Gene

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