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Aliases for CHIC1 Gene

Aliases for CHIC1 Gene

  • Cysteine Rich Hydrophobic Domain 1 2 3 5
  • Brain X-Linked Protein 3 4
  • BRX 3 4
  • Cysteine-Rich Hydrophobic Domain 1 Protein 3
  • Cysteine-Rich Hydrophobic Domain 1 2
  • Cystein-Rich Hydrophobic Domain 1 3

External Ids for CHIC1 Gene

Previous GeneCards Identifiers for CHIC1 Gene

  • GC0XP068596
  • GC0XP069957
  • GC0XU900457
  • GC0XP072566
  • GC0XP072699
  • GC0XP072782
  • GC0XP066415

Summaries for CHIC1 Gene

GeneCards Summary for CHIC1 Gene

CHIC1 (Cysteine Rich Hydrophobic Domain 1) is a Protein Coding gene. An important paralog of this gene is CHIC2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHIC1 Gene

Genomics for CHIC1 Gene

Regulatory Elements for CHIC1 Gene

Enhancers for CHIC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHIC1 on UCSC Golden Path with GeneCards custom track

Promoters for CHIC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHIC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHIC1 Gene

Chromosome:
X
Start:
73,563,148 bp from pter
End:
73,687,109 bp from pter
Size:
123,962 bases
Orientation:
Plus strand

Genomic View for CHIC1 Gene

Genes around CHIC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHIC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHIC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHIC1 Gene

Proteins for CHIC1 Gene

  • Protein details for CHIC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VXU3-CHIC1_HUMAN
    Recommended name:
    Cysteine-rich hydrophobic domain-containing protein 1
    Protein Accession:
    Q5VXU3
    Secondary Accessions:
    • A0PJZ2
    • B0QZ87
    • B9EGS5
    • Q5CZ84

    Protein attributes for CHIC1 Gene

    Size:
    224 amino acids
    Molecular mass:
    25616 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CHIC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHIC1 Gene

Proteomics data for CHIC1 Gene at MOPED

Post-translational modifications for CHIC1 Gene

Other Protein References for CHIC1 Gene

No data available for DME Specific Peptides for CHIC1 Gene

Domains & Families for CHIC1 Gene

Protein Domains for CHIC1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHIC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VXU3

UniProtKB/Swiss-Prot:

CHIC1_HUMAN :
  • Belongs to the CHIC family.
Family:
  • Belongs to the CHIC family.
genes like me logo Genes that share domains with CHIC1: view

No data available for Gene Families for CHIC1 Gene

Function for CHIC1 Gene

Phenotypes for CHIC1 Gene

genes like me logo Genes that share phenotypes with CHIC1: view

Animal Model Products

miRNA for CHIC1 Gene

miRTarBase miRNAs that target CHIC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHIC1 Gene

Localization for CHIC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHIC1 Gene

Cell membrane. Cytoplasmic vesicle. Note=Also present at a Golgi-like vesicular compartment and at scattered vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHIC1 Gene COMPARTMENTS Subcellular localization image for CHIC1 gene
Compartment Confidence
plasma membrane 4
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHIC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0016023 cytoplasmic, membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with CHIC1: view

Pathways & Interactions for CHIC1 Gene

SuperPathways for CHIC1 Gene

No Data Available

Interacting Proteins for CHIC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000362601%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000362601 for CHIC1 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CHIC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CHIC1 Gene

Drugs & Compounds for CHIC1 Gene

No Compound Related Data Available

Transcripts for CHIC1 Gene

Unigene Clusters for CHIC1 Gene

Cysteine-rich hydrophobic domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHIC1 Gene

No ASD Table

Relevant External Links for CHIC1 Gene

GeneLoc Exon Structure for
CHIC1
ECgene alternative splicing isoforms for
CHIC1

Expression for CHIC1 Gene

mRNA expression in normal human tissues for CHIC1 Gene

Protein differential expression in normal tissues from HIPED for CHIC1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CHIC1 Gene



SOURCE GeneReport for Unigene cluster for CHIC1 Gene Hs.496323

mRNA Expression by UniProt/SwissProt for CHIC1 Gene

Q5VXU3-CHIC1_HUMAN
Tissue specificity: Equally expressed in various parts of the brain.
genes like me logo Genes that share expression patterns with CHIC1: view

Protein tissue co-expression partners for CHIC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHIC1 Gene

Orthologs for CHIC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHIC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHIC1 35
  • 93.9 (n)
  • 95.98 (a)
CHIC1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHIC1 35
  • 93.7 (n)
  • 94.93 (a)
CHIC1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chic1 35
  • 89.99 (n)
  • 94.17 (a)
Chic1 16
Chic1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHIC1 35
  • 99.11 (n)
  • 100 (a)
CHIC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chic1 35
  • 89.88 (n)
  • 93.75 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves CHIC1 35
  • 83.42 (n)
  • 86.63 (a)
CHIC1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHIC1 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732617 35
  • 78.62 (n)
  • 82.07 (a)
zebrafish
(Danio rerio)
Actinopterygii chic1 35
  • 77.48 (n)
  • 90.73 (a)
chic1 36
  • 88 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5938 37
  • 58 (a)
CG5938 36
  • 63 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-266 35
  • 51.93 (n)
  • 49.28 (a)
tag-266 36
  • 43 (a)
OneToMany
Species with no ortholog for CHIC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHIC1 Gene

ENSEMBL:
Gene Tree for CHIC1 (if available)
TreeFam:
Gene Tree for CHIC1 (if available)

Paralogs for CHIC1 Gene

Paralogs for CHIC1 Gene

(1) SIMAP similar genes for CHIC1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHIC1: view

Variants for CHIC1 Gene

Sequence variations from dbSNP and Humsavar for CHIC1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747690571 -- 73,584,275(+) CTAGA(A/G)TGCGT intron-variant
rs747701756 -- 73,636,928(+) AATGC(A/G)GTATA intron-variant
rs747723210 -- 73,613,592(+) AAACC(C/T)ATTTT intron-variant
rs747730015 -- 73,578,597(+) TGTCA(-/ATT)ATTCT intron-variant
rs747738444 -- 73,628,195(+) CCTTT(A/G)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHIC1 Gene

Variant ID Type Subtype PubMed ID
nsv6958 CNV Loss 18451855
esv23979 CNV Loss 19812545
esv2490652 CNV Deletion 19546169
nsv499728 CNV Loss 21111241
nsv515213 CNV Loss 21397061

Variation tolerance for CHIC1 Gene

Gene Damage Index Score: 0.12; 2.71% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CHIC1 Gene

Disorders for CHIC1 Gene

Relevant External Links for CHIC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHIC1

No disorders were found for CHIC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHIC1 Gene

Publications for CHIC1 Gene

  1. Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. (PMID: 9321471) Simmler M.-C. … Avner P. (Mamm. Genome 1997) 2 3 4 67
  2. A new family of small, palmitoylated, membrane-associated proteins, characterized by the presence of a cysteine-rich hydrophobic motif. (PMID: 11257495) Cools J. … Marynen P. (FEBS Lett. 2001) 2 3
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CHIC1 Gene

Sources for CHIC1 Gene

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