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Aliases for CHI3L2 Gene

Aliases for CHI3L2 Gene

  • Chitinase 3-Like 2 2 3
  • Chondrocyte Protein 39 3 4
  • YKL-39 3 4
  • YKL39 3 6
  • Chitinase-3-Like Protein 2 3
  • CHIL2 3

External Ids for CHI3L2 Gene

Summaries for CHI3L2 Gene

Entrez Gene Summary for CHI3L2 Gene

  • The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is secreted and is involved in cartilage biogenesis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for CHI3L2 Gene

CHI3L2 (Chitinase 3-Like 2) is a Protein Coding gene. GO annotations related to this gene include chitinase activity and chitin binding. An important paralog of this gene is CHIT1.

UniProtKB/Swiss-Prot for CHI3L2 Gene

  • Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHI3L2 Gene

Genomics for CHI3L2 Gene

Genomic Location for CHI3L2 Gene

Start:
111,200,771 bp from pter
End:
111,243,440 bp from pter
Size:
42,670 bases
Orientation:
Plus strand

Genomic View for CHI3L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHI3L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHI3L2 Gene

Regulatory Elements for CHI3L2 Gene

Proteins for CHI3L2 Gene

  • Protein details for CHI3L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15782-CH3L2_HUMAN
    Recommended name:
    Chitinase-3-like protein 2
    Protein Accession:
    Q15782
    Secondary Accessions:
    • A6NNY3
    • B4DPR7
    • Q15749
    • Q15783
    • Q5VUV7
    • Q96F97

    Protein attributes for CHI3L2 Gene

    Size:
    390 amino acids
    Molecular mass:
    43501 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB04534.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAC50597.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CHI3L2 Gene

    Alternative splice isoforms for CHI3L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHI3L2 Gene

Proteomics data for CHI3L2 Gene at MOPED

Post-translational modifications for CHI3L2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys199, Lys329, Lys340, Lys345, and Lys384
  • Glycosylation at Asn35

No data available for DME Specific Peptides for CHI3L2 Gene

Domains for CHI3L2 Gene

UniProtKB/Swiss-Prot:

CH3L2_HUMAN
Family:
  • Belongs to the glycosyl hydrolase 18 family.:
    • Q15782
genes like me logo Genes that share domains with CHI3L2: view

No data available for Gene Families for CHI3L2 Gene

Function for CHI3L2 Gene

Molecular function for CHI3L2 Gene

GENATLAS Biochemistry: chitinase 3-like 2,expressed in chondrocytes,synovial cell,lung,heart
UniProtKB/Swiss-Prot Function: Lectin that binds chitooligosaccharides and other glycans with high affinity, but not heparin. Has no chitinase activity.

Gene Ontology (GO) - Molecular Function for CHI3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds --
GO:0004568 NOT chitinase activity IDA 22742450
GO:0008061 chitin binding IDA 22742450
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with CHI3L2: view

miRNA for CHI3L2 Gene

miRTarBase miRNAs that target CHI3L2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHI3L2 Gene

Localization for CHI3L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHI3L2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHI3L2 Gene COMPARTMENTS Subcellular localization image for CHI3L2 gene
Compartment Confidence
extracellular 4
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CHI3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
genes like me logo Genes that share ontologies with CHI3L2: view

Pathways for CHI3L2 Gene

SuperPathways for CHI3L2 Gene

No Data Available

Interacting Proteins for CHI3L2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000358763%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000300289%0d%0a
Selected Interacting proteins: ENSP00000358763 for CHI3L2 Gene via STRING

Gene Ontology (GO) - Biological Process for CHI3L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006032 NOT chitin catabolic process IBA --
GO:0006955 immune response IBA --
genes like me logo Genes that share ontologies with CHI3L2: view

No data available for Pathways by source for CHI3L2 Gene

Transcripts for CHI3L2 Gene

Unigene Clusters for CHI3L2 Gene

Chitinase 3-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHI3L2 Gene

No ASD Table

Relevant External Links for CHI3L2 Gene

GeneLoc Exon Structure for
CHI3L2
ECgene alternative splicing isoforms for
CHI3L2

Expression for CHI3L2 Gene

mRNA expression in normal human tissues for CHI3L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHI3L2 Gene

This gene is overexpressed in Minor Salivary Gland (8.2) and Lung (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHI3L2 Gene

SOURCE GeneReport for Unigene cluster for CHI3L2 Gene Hs.514840

mRNA Expression by UniProt/SwissProt for CHI3L2 Gene

Q15782-CH3L2_HUMAN
Tissue specificity: Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
genes like me logo Genes that share expressions with CHI3L2: view

Orthologs for CHI3L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHI3L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHI3L2 36
  • 99.4 (n)
  • 99.23 (a)
CHI3L2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHI3L2 36
  • 87.99 (n)
  • 88.25 (a)
CHI3L2 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHI3L2 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 36 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 45 (a)
OneToMany
-- 37
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cht7 37
  • 17 (a)
OneToMany
Cht3 38
  • 37 (a)
CG10531 38
  • 37 (a)
CG9357 38
  • 38 (a)
CG3044 38
  • 29 (a)
Chit 38
  • 26 (a)
Idgf4 38
  • 26 (a)
Cht1 38
  • 36 (a)
Cht2 38
  • 34 (a)
CG2989 38
  • 40 (a)
worm
(Caenorhabditis elegans)
Secernentea cht-1 37
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CTS2 37
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8046 37
  • 21 (a)
OneToMany
Species with no ortholog for CHI3L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for CHI3L2 Gene

ENSEMBL:
Gene Tree for CHI3L2 (if available)
TreeFam:
Gene Tree for CHI3L2 (if available)

Paralogs for CHI3L2 Gene

Paralogs for CHI3L2 Gene

Pseudogenes.org Pseudogenes for CHI3L2 Gene

genes like me logo Genes that share paralogs with CHI3L2: view

Variants for CHI3L2 Gene

Sequence variations from dbSNP and Humsavar for CHI3L2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs8535 -- 111,243,307(+) CCAGG(A/C)TGGCC utr-variant-3-prime
rs13721 - 111,241,360(+) TCACG(A/C/T)GGCTC synonymous-codon, reference, missense
rs755467 -- 111,227,801(+) GGAAA(G/T)TTGGT intron-variant, upstream-variant-2KB
rs942690 -- 111,238,285(-) GAAGA(A/G)ATTTA intron-variant
rs942693 -- 111,241,536(-) GCCTC(A/G)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHI3L2 Gene

Variant ID Type Subtype PubMed ID
nsv10639 CNV Gain 18304495
nsv463250 CNV Loss 19166990

Relevant External Links for CHI3L2 Gene

HapMap Linkage Disequilibrium report
CHI3L2
Human Gene Mutation Database (HGMD)
CHI3L2

Disorders for CHI3L2 Gene

Relevant External Links for CHI3L2

Genetic Association Database (GAD)
CHI3L2
Human Genome Epidemiology (HuGE) Navigator
CHI3L2
genes like me logo Genes that share disorders with CHI3L2: view

No data available for UniProtKB/Swiss-Prot for CHI3L2 Gene

Publications for CHI3L2 Gene

  1. Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. (PMID: 8702629) Hu B. … Price P.A. (J. Biol. Chem. 1996) 2 3 4 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. (PMID: 12435396) Steck E. … Richter W. (Biochem. Biophys. Res. Commun. 2002) 3 23
  4. Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties. (PMID: 22742450) Schimpl M. … van Aalten D.M. (Biochem. J. 2012) 3 4
  5. Human YKL39 (chitinase 3-like protein 2), an osteoarthritis-associated gene, enhances proliferation and type II collagen expression in ATDC5 cells. (PMID: 23291184) Miyatake K. … Muneta T. (Biochem. Biophys. Res. Commun. 2013) 3

Products for CHI3L2 Gene

Sources for CHI3L2 Gene

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