CHI3L1 Gene
protein-coding GIFtS: 60
GCID: GC01M203148
|
|
chitinase 3-like 1 (cartilage glycoprotein-39)
| |
Aliases
for CHI3L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chitinase 3-Like 1 (Cartilage Glycoprotein-39)1 2 | | YKL-402 3 | | GP391 2 5 | | HCGP-391 | | YKL401 2 5 | | ASRT72 5 | | Cartilage Glycoprotein 392 3 | | HC-Gp391 | | 39 KDa Synovial Protein2 3 | | HCGP-3P2 | | CGP-392 3 | | YYL-402 | | GP-392 3 | | Chitinase-3-Like Protein 12 |
Export aliases for CHI3L1 gene to outside databasesPrevious GC identifers: GC01M200831 GC01M198577 GC01M199614 GC01M200436 GC01M199879 GC01M201414 GC01M174313 |
Summaries
for CHI3L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHI3L1:
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungalcell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene encodes aglycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is secreted byactivated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a role in theprocess of inflammation and tissue remodeling. (provided by RefSeq, Sep 2009)
UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222Function: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or intissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in theirenvironment
Gene Wiki entry for CHI3L1
|
Genomic Views
for CHI3L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHI3L1 gene promoter:
c-Fos AP-1 ATF-2 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHI3L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHI3L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q32.1CHI3L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M203148: view genomic region
(about GC identifiers)
Start:
|
203,148,059 bp from pter |
End:
|
203,155,922 bp from pter |
Size:
|
7,864 bases |
Orientation:
|
minus strand |
|
Proteins
for CHI3L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222 (See
protein sequence)Recommended Name: Chitinase-3-like protein 1 precursor Size: 383 amino acids; 42625 Da
Subunit: Monomer
Subcellular location: Secreted, extracellular space
Caution: Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu whichis an active site residue. Therefore this protein lacks chitinase activity
6/8 PDB 3D structures from  and Proteopedia  for CHI3L1 (see all 8):1HJV (3D)
1HJW (3D)
1HJX (3D)
1LA7 (3D)
1NWR (3D)
1NWS (3D)
Secondary accessions: B2R7B0 P30923 Q8IVA4 Q96HI7Explore the universe of human proteins at neXtProt for CHI3L1: NX_P36222
Post-translational modifications:
Glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P36222
CHI3L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001267.2
ENSEMBL proteins: ENSP00000255409 ENSP00000385350
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CHI3L1 for ontologies About GeneDecksing
CHI3L1 Antibody Products:
Assay Products for CHI3L1: |
Protein
Domains /
Families
for CHI3L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHI3L1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P36222ProtoNet protein and cluster: P36222 3 Blocks protein families: IPB001223 Glycoside hydrolase IPB001579 Glycoside hydrolase IPB011583 Chitinase II
UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222Similarity: Belongs to the glycosyl hydrolase 18 family |
Function
for CHI3L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222Function: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or intissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in theirenvironment Genatlas biochemistry entry for CHI3L1:chitinase 3-like 1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHI3L1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHI3L1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHI3L1 (NM_001276) | |  | Sino Biological Human cDNA Clone for CHI3L1 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHI3L1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHI3L1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHI3L1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
CHI3L1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Chi3l1tm1Eli for CHI3L1
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Chi3l1):
CHI3L1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHI3L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Amino sugar and nucleotide sugar metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for CHI3L1):
CHI3L1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHI3L1
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for CHI3L1 (ENSP000002554094) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table
CHI3L1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHI3L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CHI3L1 for compounds About GeneDecksing
 Browse Tocris compounds for CHI3L1
2 DrugBank Compounds for CHI3L1 About this table
6 Novoseek chemical compound relationships for CHI3L1 gene About this table
Search CenterWatch for drugs/clinical trials and news about CHI3L1 / CH3L1
|
Transcripts
for CHI3L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHI3L1 gene: NM_001276.2 Unigene Cluster for CHI3L1: Chitinase 3-like 1 (cartilage glycoprotein-39) Hs.382202 [show with all ESTs]Unigene Representative Sequence: NM_0012765 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000255409(uc001gzi.2 uc001gzj.2) ENST00000473185(uc001gzk.1)
ENST00000404436 ENST00000478742 ENST00000472064
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHI3L1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHI3L1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHI3L1 (NM_001276) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHI3L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHI3L1 |
Additional cDNA sequence: AK130142.1 AK130200.1 AK225266.1 AK225584.1 AK312911.1 BC008568.1 BC038354.1 BC039132.1 BT007223.1 M80927.1 18 DOTS entries: DT.40296749 DT.315893 DT.100826059 DT.97808552 DT.100826057 DT.101984646 DT.95131737 DT.95220502 DT.121342414 DT.100826055 DT.95131781 DT.99956862 DT.99953221 DT.100031084 DT.100826062 DT.121342401 DT.121342404 DT.121342410 24/401 AceView cDNA sequences (see all 401): BG743506 CA439403 BP373883 BC008568 CR623103 CD678557 AU100131 AA282995 AW468457 CB152798 AA166961 BQ181277 BX102071 BQ181106 BM703613 BG675109 BQ710194 BG740681 AI903390 AI708952 CA415986 AA464977 BQ925412 BQ183165
GeneLoc Exon Structure
5/18 Alternative Splicing Database (ASD) splice patterns (SP) for CHI3L1 (see all 18) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9a | · | 9b | · | 9c | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | | | - | | - | | - | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | |
| ExUns: | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CHI3L1
|
Expression
for CHI3L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHI3L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATGGGCCC
About this image
See CHI3L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHI3L1
SOURCE GeneReport for Unigene cluster: Hs.382202
UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222Tissue specificity: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver.Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts
SABiosciences Expression via Pathway-Focused PCR Array including CHI3L1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHI3L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHI3L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHI3L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHI3L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHI3L1 |
Orthologs
for CHI3L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CHI3L1 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for CHI3L1 (if available)
TreeFam Gene Tree for CHI3L1 (if available) |
Paralogs
for CHI3L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHI3L1 gene
- CHIA2 CHIT12 CHI3L22 OVGP12
5 SIMAP similar genes for CHI3L1 using alignment to 5 protein entries: CH3L1_HUMAN (see all proteins):CHI3L2 CHIA CHIT1 OVGP1 FLJ00314
CHI3L1 for paralogs About GeneDecksing
|
Genomic Variants
for CHI3L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHI3L1 (203148059 - 203155922 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHI3L1: --
Human Gene Mutation Database (HGMD): CHI3L1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHI3L1 |
|
Disorders
/ Diseases
for CHI3L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHI3L1 for disorders About GeneDecksing
OMIM gene information: 601525
OMIM disorders: 181500 611960
UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222
A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7)[MIM:611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea,bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopicdermatitis
20/83  diseases for CHI3L1 (see all 83): About MalaCardsextraskeletal myxoid chondrosarcoma central nervous system lymphoma myxoid chondrosarcoma chitotriosidase deficiency
food allergy inflammatory bowel disease chronic obstructive pulmonary disease lupus erythematosus
ankylosing spondylitis rheumatoid arthritis myocardial infarction ischemic heart disease
atrial fibrillation malignant glioma acute myocardial infarction squamous cell carcinoma of the head and neck
systemic lupus erythematosus renal cell carcinoma squamous cell carcinoma spondylitis
1 disease from the University of Copenhagen DISEASES database for CHI3L1:Arthritis 10/36 Novoseek disease relationships for CHI3L1 gene (see all 36) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glioblastoma |
65.1 |
24 |
15867231 (5), 15788675 (4), 12957359 (3), 19255724 (3) (see all 9) |
| osteoarthritis |
62.9 |
9 |
15730740 (1), 11300743 (1), 20422912 (1), 10380840 (1) (see all 7) |
| rheumatoid arthritis |
61.7 |
27 |
11136874 (2), 15569925 (2), 19003601 (2), 15059280 (1) (see all 18) |
| inflammation |
50.5 |
42 |
16153848 (3), 19908331 (3), 20010462 (2), 17631744 (2) (see all 24) |
| liver fibrosis |
48.8 |
10 |
18217402 (4), 16188216 (3), 9200292 (2), 19003601 (1) |
| osteoarthritis hip |
46.9 |
1 |
11005786 (1) |
| osteoarthritis knee |
43.5 |
1 |
19308408 (1) |
| recurrent breast cancer |
39.3 |
2 |
14555515 (1), 7577068 (1) |
| inflammatory bowel diseases |
38.7 |
5 |
12825867 (1), 19908331 (1), 10873965 (1), 19003601 (1) |
| spondylitis |
38.4 |
1 |
12951872 (1) |
Human Genome Epidemiology (HuGE) Navigator: CHI3L1 (20 documents)
Export disorders for CHI3L1 gene to outside databases
|
Publications
for CHI3L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHI3L1 gene, integrated from 9 sources (see all 245):
(articles sorted by number of sources associating them with CHI3L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. (PubMed id 8245017)1, 2, 3, 9 Hakala B.E.... Recklies A.D. (1993)
- Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. (PubMed id 9244440)1, 2, 3 Rehli M....Andreesen R. (1997)
- Crystal structure and carbohydrate-binding properties of the human cartilage glycoprotein-39. (PubMed id 12851408)1, 2, 9 Fusetti F.... Dijkstra B.W. (2003)
- Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes. (PubMed id 12775711)1, 2, 9 Houston D.R.... van Aalten D.M.F. (2003)
- Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. (PubMed id 9492324)1, 2, 9 Renkema G.H....Aerts J.M. (1998)
- Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. (PubMed id 18403759)1, 2 Ober C.... Chupp G.L. (2008)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Human synovial cells secrete a 39 kDa protein similar to a bovine mammary protein expressed during the non-lactating period. (PubMed id 2375755)1, 2 Nyirkos P. and Golds E.E. (1990)
- Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization. (PubMed id 10772238)1, 9 Connor J.R....Gowen M. (2000)
|
External Searches for CHI3L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHI3L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHI3L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHI3L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CHI3L1 gene:
Search GeneIP for patents involving CHI3L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHI3L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHI3L1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHI3L1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHI3L1 | | | OriGene Protein Over-expression Lysate for CHI3L1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHI3L1 | | OriGene 3'-UTR Clone for CHI3L1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHI3L1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHI3L1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CHI3L1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHI3L1 | | OriGene Custom Protein Services for CHI3L1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHI3L1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHI3L1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHI3L1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHI3L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHI3L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHI3L1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CHI3L1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CHI3L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHI3L1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CHI3L1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHI3L1 |
|
|
|
|
