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CHI3L1 Gene

protein-coding   GIFtS: 61
GCID: GC01M203148

Chitinase 3-Like 1 (Cartilage Glycoprotein-39)

  See CHI3L1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chitinase 3-Like 1 (Cartilage Glycoprotein-39)1 2     ASRT72 5
Cartilage Glycoprotein 392 3     GP392 5
39 KDa Synovial Protein2 3     YKL402 5
CGP-392 3     HC-gp392
GP-392 3     HCGP-3P2
YKL-402 3     YYL-402
hCGP-392 3     Chitinase-3-Like Protein 12

External Ids:    HGNC: 19321   Entrez Gene: 11162   Ensembl: ENSG000001330487   OMIM: 6015255   UniProtKB: P362223   

Export aliases for CHI3L1 gene to outside databases

Previous GC identifers: GC01M200831 GC01M198577 GC01M199614 GC01M200436 GC01M199879 GC01M201414 GC01M174313


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHI3L1 Gene:
Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and
fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This gene
encodes a glycoprotein member of the glycosyl hydrolase 18 family. The protein lacks chitinase activity and is
secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. The protein is thought to play a
role in the process of inflammation and tissue remodeling. (provided by RefSeq, Sep 2009)

GeneCards Summary for CHI3L1 Gene:
CHI3L1 (chitinase 3-like 1 (cartilage glycoprotein-39)) is a protein-coding gene. Diseases associated with CHI3L1 include asthma-related traits 7, and pelvic inflammatory disease. GO annotations related to this gene include extracellular matrix structural constituent and chitin binding. An important paralog of this gene is CHIA.

UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222
Function: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens,
or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes
in their environment

Gene Wiki entry for CHI3L1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHI3L1 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHI3L1 promoter sequence
   Search Chromatin IP Primers for CHI3L1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHI3L1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

CHI3L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHI3L1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M203148:  view genomic region     (about GC identifiers)

Start:
203,148,059 bp from pter      End:
203,155,922 bp from pter
Size:
7,864 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222 (See protein sequence)
Recommended Name: Chitinase-3-like protein 1 precursor  
Size: 383 amino acids; 42625 Da
Subunit: Monomer
Caution: Although it belongs to the glycosyl hydrolase 18 family, Leu-140 is present instead of the conserved Glu
which is an active site residue. Therefore this protein lacks chitinase activity
Selected PDB 3D structures from and Proteopedia for CHI3L1 (see all 8):
1HJV (3D)        1HJW (3D)        1HJX (3D)        1LA7 (3D)        1NWR (3D)        1NWS (3D)    
Secondary accessions: B2R7B0 P30923 Q8IVA4 Q96HI7

Explore the universe of human proteins at neXtProt for CHI3L1: NX_P36222

Explore proteomics data for CHI3L1 at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Asn60
  • Modification sites at PhosphoSitePlus

  • See CHI3L1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001267.2  
    ENSEMBL proteins: 
     ENSP00000255409   ENSP00000385350  

    CHI3L1 Human Recombinant Protein Products:

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    Sino Biological Recombinant Protein for CHI3L1
    Sino Biological Cell Lysate for CHI3L1
    ProSpec Recombinant Protein for CHI3L1
    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for CHI3L1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR011583 Chitinase_II
     IPR017853 Glycoside_hydrolase_SF
     IPR001223 Glyco_hydro18cat
     IPR028538 CHI3L1
     IPR013781 Glyco_hydro_catalytic_dom

    Graphical View of Domain Structure for InterPro Entry P36222

    ProtoNet protein and cluster: P36222

    3 Blocks protein domains:
    IPB001223 Glycoside hydrolase
    IPB001579 Glycoside hydrolase
    IPB011583 Chitinase II


    UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222
    Similarity: Belongs to the glycosyl hydrolase 18 family


    Find genes that share domains with CHI3L1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CH3L1_HUMAN, P36222
    Function: Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens,
    or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes
    in their environment

         Genatlas biochemistry entry for CHI3L1:
    chitinase 3-like 1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004553hydrolase activity, hydrolyzing O-glycosyl compounds ----
    GO:0004568NOT chitinase activity IDA8245017
    GO:0005201extracellular matrix structural constituent NAS8245017
    GO:0008061chitin binding IDA12775711
         
    Find genes that share ontologies with CHI3L1           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chi3l1):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with CHI3L1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chil1tm1Eli for CHI3L1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHI3L1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CH3L1_HUMAN, P36222: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum4
    lysosome1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix NAS8245017
    GO:0005615extracellular space IDA8245017
    GO:0005737cytoplasm ISS--
    GO:0005783endoplasmic reticulum ISS--

    Find genes that share ontologies with CHI3L1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CHI3L1: 
              Allergy & Asthma in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CHI3L1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for CHI3L1 (ENSP000002554094) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HEXBENSP000002614164STRING: ENSP00000261416
    NAGKENSP000002442044STRING: ENSP00000244204
    HEXAENSP000002680974STRING: ENSP00000268097
    RENBPENSP000003773034STRING: ENSP00000377303
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process IEA--
    GO:0006032chitin catabolic process IEA--
    GO:0006954inflammatory response IEP16234240
    GO:0007250activation of NF-kappaB-inducing kinase activity ISS--
    GO:0009612response to mechanical stimulus IEP--

    Find genes that share ontologies with CHI3L1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHI3L1 (CH3L1)

    2 DrugBank Compounds for CHI3L1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target--10592235
    Beta-D-Mannose-- 7322-31-8target--10592235

    6 Novoseek inferred chemical compound relationships for CHI3L1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chitin 64.4 8 12851408 (3), 9492324 (2), 17392594 (1), 19003601 (1) (see all 5)
    hyaluronic acid 41.3 23 16188216 (4), 18371145 (3), 19934106 (1), 16396978 (1) (see all 5)
    p003 27.2 2 11005786 (1), 17236752 (1)
    nitric oxide 0 10 17631744 (4), 17368882 (1)
    estrogen 0 3 14555515 (3)
    cycloheximide 0 1 11315922 (1)



    Find genes that share compounds with CHI3L1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHI3L1 gene: 
    NM_001276.2  

    Unigene Cluster for CHI3L1:

    Chitinase 3-like 1 (cartilage glycoprotein-39)
    Hs.382202  [show with all ESTs]
    Unigene Representative Sequence: NM_001276
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000473185(uc001gzk.1) ENST00000255409(uc001gzi.2 uc001gzj.2)
    ENST00000404436 ENST00000478742 ENST00000472064
    miRNA
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    hsa-miR-24 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidCHI3L1 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat CHI3L1
      QuantiFast Probe-based Assays in human, mouse, rat CHI3L1

    Additional mRNA sequence: 

    AK130142.1 AK130200.1 AK225266.1 AK225584.1 AK312911.1 BC008568.1 BC038354.1 BC039132.1 
    BT007223.1 M80927.1 

    18 DOTS entries:

    DT.40296749  DT.315893  DT.100826059  DT.97808552  DT.100826057  DT.101984646  DT.95131737  DT.95220502 
    DT.121342414  DT.100826055  DT.95131781  DT.99956862  DT.99953221  DT.100031084  DT.100826062  DT.121342401 
    DT.121342404  DT.121342410 

    Selected AceView cDNA sequences (see all 401):

    BM703613 AI708952 AI903390 BQ710144 BC008568 AW086114 BG696335 AU100131 
    AA465046 N39595 CR623103 AW468457 BQ710194 BG743506 BQ183165 BG743108 
    BQ181277 CB133072 CB152798 AA464977 CB132956 BT007223 BM702158 BG740681 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHI3L1 (see all 18)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d · 8e · 8f ^ 9a · 9b · 9c ^
    SP1:                          -                 -           -     -     -                                   -     -                             -               
    SP2:                          -     -           -           -     -     -                                   -     -                                             
    SP3:                          -                 -           -     -                                                                                             
    SP4:                          -                 -           -     -     -                 -                                                                     
    SP5:                                            -           -     -                                         -     -                                             

    ExUns: 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for CHI3L1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHI3L1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATGGGCCC
    CHI3L1 Expression
    About this image


    CHI3L1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
     
     Eye (Sensory Organs)
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Lung (Respiratory System)
     
     Bone (Muscoskeletal System)
    CHI3L1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHI3L1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.382202

    UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222
    Tissue specificity: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver.
    Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts

        Pathway & Disease-focused RT2 Profiler PCR Array including CHI3L1: 
              Allergy & Asthma in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHI3L1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHI3L1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chi3l15
    Chil11
    chitinase 3-like 15
    chitinase-like 11
    78.86(n)1
    73.68(a)1
      1 (58.15 cM)5
    126541  NM_007695.31  NP_031721.21 
     1341821765 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    51(a)
    many ↔ many
    AAWZ02040495(1046-5269)
    zebrafish
    (Danio rerio)
    Actinopterygii BC045331.12   -- 73.07(n)    BC045331.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG18693 heparin binding 45(a)
    (best of 12)
      63B1   --
    worm
    (Caenorhabditis elegans)
    Secernentea cht-16
    Protein CHT-1 (cht-1) mRNA, complete cds
    24(a)
    1 → many
    X(3397608-3400017) WBGene00000503
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CTS26
    Putative chitinase, functionally complements A. go...
    21(a)
    1 → many
    IV(1219413-1220948) YDR371W


    ENSEMBL Gene Tree for CHI3L1 (if available)
    TreeFam Gene Tree for CHI3L1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHI3L1 gene
    CHIA2  CHIT12  CHI3L22  OVGP12  
    5 SIMAP similar genes for CHI3L1 using alignment to 5 protein entries:     CH3L1_HUMAN (see all proteins):
    CHI3L2    CHIA    CHIT1    OVGP1    FLJ00314

    Find genes that share paralogs with CHI3L1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHI3L1 (see all 332)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127553201,2
    H--174321557(+) CCGTGT/GCtttt 1 -- us2k1 trp34Minor allele frequency- G:0.00NS EA 394
    rs1998189581,2
    --203156436(+) TTTTT-/TCTTTTT 1 -- us2k10--------
    rs1162868851,2
    F--209684621(+) CACTCT/CGCAGG 1 -- ds50011Minor allele frequency- C:0.01WA 118
    rs9033571,2
    C,F,A,H--209684655(-) TCATGC/TACCCT 1 -- ds500121Minor allele frequency- T:0.40EA NA MN NS WA CSA 1254
    rs22979441,2
    C--209684657(+) GGTGCA/GTGAGA 1 -- ds50015Minor allele frequency- G:0.12NA WA EA 244
    rs22979451,2
    C,F,H--209684707(+) TCAGGG/TCTTTC 1 -- ds500113Minor allele frequency- T:0.08EA NS NA WA 3002
    rs1834253421,2
    --209684760(+) CAGAAG/TAGAGG 1 -- ds50010--------
    rs175311681,2
    C,F--209684891(+) AGGCCA/CTCAGC 1 -- ds50015Minor allele frequency- C:0.02NA 264
    rs556988611,2
    C--209684981(+) CATGGC/TGGCCT 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1888234131,2
    --209685072(+) TGGGCA/GCTCAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CHI3L1 (203148059 - 203155922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHI3L1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873110CNV Loss21882294
    nsv832370CNV Loss17160897

    Human Gene Mutation Database (HGMD): CHI3L1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHI3L1
    DNA2.0 Custom Variant and Variant Library Synthesis for CHI3L1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601525   
    OMIM disorders: 181500  611960  
    UniProtKB/Swiss-Prot: CH3L1_HUMAN, P36222
  • Asthma-related traits 7 (ASRT7) [MIM:611960]: Asthma-related traits include clinical symptoms of asthma,
    such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test,
    serum IgE levels, atopy and atopic dermatitis. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry

  • 9 diseases for CHI3L1:    
    About MalaCards
    asthma-related traits 7    pelvic inflammatory disease    myxoid chondrosarcoma    schizophrenia
    food allergy    central nervous system lymphoma    extraskeletal myxoid chondrosarcoma    spondylitis
    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for CHI3L1:
    Rheumatoid arthritis     Osteoarthritis

    Find genes that share disorders with CHI3L1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CHI3L1 gene (see all 36)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glioblastoma 65.1 24 15867231 (5), 15788675 (4), 12957359 (3), 19255724 (3) (see all 9)
    osteoarthritis 62.9 9 15730740 (1), 11300743 (1), 20422912 (1), 10380840 (1) (see all 7)
    rheumatoid arthritis 61.7 27 11136874 (2), 15569925 (2), 19003601 (2), 15059280 (1) (see all 18)
    inflammation 50.5 42 16153848 (3), 19908331 (3), 20010462 (2), 17631744 (2) (see all 24)
    liver fibrosis 48.8 10 18217402 (4), 16188216 (3), 9200292 (2), 19003601 (1)
    osteoarthritis hip 46.9 1 11005786 (1)
    osteoarthritis knee 43.5 1 19308408 (1)
    recurrent breast cancer 39.3 2 14555515 (1), 7577068 (1)
    inflammatory bowel diseases 38.7 5 12825867 (1), 19908331 (1), 10873965 (1), 19003601 (1)
    spondylitis 38.4 1 12951872 (1)

    Genetic Association Database (GAD): CHI3L1
    Human Genome Epidemiology (HuGE) Navigator: CHI3L1 (20 documents)

    Export disorders for CHI3L1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHI3L1 gene, integrated from 10 sources (see all 278):
    (articles sorted by number of sources associating them with CHI3L1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human cartilage gp-39, a major secretory product of articular chondrocytes and synovial cells, is a mammalian member of a chitinase protein family. (PubMed id 8245017)1, 2, 3, 9 Hakala B.E.... Recklies A.D. (J. Biol. Chem. 1993)
    2. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. (PubMed id 18403759)1, 2, 4 Ober C.... Chupp G.L. (N. Engl. J. Med. 2008)
    3. Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. (PubMed id 9244440)1, 2, 3 Rehli M.... Andressen R. (Genomics 1997)
    4. A CHI3L1 gene polymorphism is associated with serum levels of YKL-40, a novel sarcoidosis marker. (PubMed id 17236752)1, 4, 9 Kruit A....van den Bosch J.M. (Respir Med 2007)
    5. Genetic variation in the promoter region of chitinase 3-like 1 is associated with atopy. (PubMed id 19106306)1, 4, 9 Sohn M.H....Lee M.G. (Am. J. Respir. Crit. Care Med. 2009)
    6. Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. (PubMed id 17160890)1, 4, 9 Zhao X....He L. (Am. J. Hum. Genet. 2007)
    7. The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis. (PubMed id 20051317)1, 4, 9 Ohi K....Takeda M. (Schizophr. Res. 2010)
    8. Association of polymorphisms of the CHI3L1 gene with asthma and atopy: a populations-based study of 6514 Danish adults. (PubMed id 19568425)1, 4, 9 Rathcke C.N....Linneberg A. (PLoS ONE 2009)
    9. Chitinase-3-like 1 (CHI3L1) gene and schizophrenia: genetic association and a potential functional mechanism. (PubMed id 18281018)1, 4, 9 Yang M.S....Corvin A. (Biol. Psychiatry 2008)
    10. No association of (-131C--&gt;G) variant of CHI3L1 gene with risk of glioblastoma and prognosis. (PubMed id 19255724)1, 4, 9 Boisselier B....Sanson M. (J. Neurooncol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1116 HGNC: 1932 AceView: CHI3L1 Ensembl:ENSG00000133048 euGenes: HUgn1116
    ECgene: CHI3L1 H-InvDB: CHI3L1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHI3L1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHI3L1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHI3L1 gene:
    Search GeneIP for patents involving CHI3L1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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