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Aliases for CHGB Gene

Aliases for CHGB Gene

  • Chromogranin B 2 3
  • Secretogranin B 2 3
  • Secretogranin I 3 4
  • Chromogranin-B 3 4
  • SCG1 3 4
  • CGB 3 4
  • SgI 3 4
  • Secretogranin 1 2

External Ids for CHGB Gene

Previous HGNC Symbols for CHGB Gene

  • SCG1

Previous GeneCards Identifiers for CHGB Gene

  • GC20P005880
  • GC20P005840
  • GC20P005887
  • GC20P005848

Summaries for CHGB Gene

Entrez Gene Summary for CHGB Gene

  • This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

GeneCards Summary for CHGB Gene

CHGB (Chromogranin B) is a Protein Coding gene. Diseases associated with CHGB include mixed ductal-endocrine carcinoma and glucagonoma. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for CHGB Gene

  • Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides

Gene Wiki entry for CHGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHGB Gene

Genomics for CHGB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHGB Gene

Chromosome:
20
Start:
5,911,328 bp from pter
End:
5,925,361 bp from pter
Size:
14,034 bases
Orientation:
Plus strand

Genomic View for CHGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHGB Gene

Proteins for CHGB Gene

  • Protein details for CHGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05060-SCG1_HUMAN
    Recommended name:
    Secretogranin-1
    Protein Accession:
    P05060
    Secondary Accessions:
    • A8K021
    • Q59EU9
    • Q6IBS6
    • Q9BQV6
    • Q9UC25
    • Q9UJA6

    Protein attributes for CHGB Gene

    Size:
    677 amino acids
    Molecular mass:
    78276 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CHGB Gene

Proteomics data for CHGB Gene at MOPED

Post-translational modifications for CHGB Gene

  • Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
  • O-glycosylated.
  • Glycosylation at Asn 315
  • Modification sites at PhosphoSitePlus

Other Protein References for CHGB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CHGB (Chromogranin B)

No data available for DME Specific Peptides for CHGB Gene

Domains & Families for CHGB Gene

Gene Families for CHGB Gene

Protein Domains for CHGB Gene

Suggested Antigen Peptide Sequences for CHGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05060

UniProtKB/Swiss-Prot:

SCG1_HUMAN :
  • Belongs to the chromogranin/secretogranin protein family.
Family:
  • Belongs to the chromogranin/secretogranin protein family.
genes like me logo Genes that share domains with CHGB: view

Function for CHGB Gene

Molecular function for CHGB Gene

GENATLAS Biochemistry:
chromogranin B (catecholamine and norepenephrine secretory protein)
UniProtKB/Swiss-Prot Function:
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides

Gene Ontology (GO) - Molecular Function for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 3608978
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with CHGB: view

Phenotypes for CHGB Gene

genes like me logo Genes that share phenotypes with CHGB: view

Animal Models for CHGB Gene

MGI Knock Outs for CHGB:

Animal Model Products

miRNA for CHGB Gene

miRTarBase miRNAs that target CHGB

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHGB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CHGB Gene

Localization for CHGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHGB Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHGB Gene COMPARTMENTS Subcellular localization image for CHGB gene
Compartment Confidence
extracellular 5
golgi apparatus 2
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with CHGB: view

Pathways & Interactions for CHGB Gene

SuperPathways for CHGB Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHGB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CHGB Gene

Drugs & Compounds for CHGB Gene

(11) Drugs for CHGB Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Dopamine Approved Pharma Full agonist, Agonist 2814
Norepinephrine Approved Pharma 206
Potassium Experimental Pharma 0
Sucrose Experimental Pharma 0

(6) Additional Compounds for CHGB Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CATECHOLAMINE
dithiothreitol
inositol 1,4,5 trisphosphate
Oligonucleotide
Peptidylglycine
genes like me logo Genes that share compounds with CHGB: view

Transcripts for CHGB Gene

mRNA/cDNA for CHGB Gene

Unigene Clusters for CHGB Gene

Chromogranin B (secretogranin 1):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHGB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHGB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6:
SP7: - - - - -

Relevant External Links for CHGB Gene

GeneLoc Exon Structure for
CHGB
ECgene alternative splicing isoforms for
CHGB

Expression for CHGB Gene

mRNA expression in normal human tissues for CHGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHGB Gene

This gene is overexpressed in Pituitary (x18.6), Brain - Cerebellar Hemisphere (x9.1), Brain - Cerebellum (x6.1), and Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CHGB Gene

This gene is overexpressed in Cerebrospinal fluid (35.5) and Adrenal (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHGB Gene



SOURCE GeneReport for Unigene cluster for CHGB Gene Hs.516874

mRNA Expression by UniProt/SwissProt for CHGB Gene

P05060-SCG1_HUMAN
Tissue specificity: Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.
genes like me logo Genes that share expression patterns with CHGB: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for CHGB Gene

Orthologs for CHGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHGB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHGB 35
  • 78.6 (n)
  • 68.6 (a)
CHGB 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHGB 35
  • 83.74 (n)
  • 75 (a)
CHGB 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chgb 35
  • 76.28 (n)
  • 65.71 (a)
Chgb 16
Chgb 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHGB 35
  • 99.11 (n)
  • 98.23 (a)
CHGB 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chgb 35
  • 76.21 (n)
  • 66.42 (a)
oppossum
(Monodelphis domestica)
Mammalia CHGB 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHGB 36
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHGB 35
  • 53.66 (n)
  • 38.54 (a)
CHGB 36
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHGB 36
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19044 35
Species with no ortholog for CHGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CHGB Gene

ENSEMBL:
Gene Tree for CHGB (if available)
TreeFam:
Gene Tree for CHGB (if available)

Paralogs for CHGB Gene

No data available for Paralogs for CHGB Gene

Variants for CHGB Gene

Sequence variations from dbSNP and Humsavar for CHGB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2821 -- 5,925,133(+) TTTAT(A/C)TACCC utr-variant-3-prime
rs236136 -- 5,909,425(+) TGCAG(C/T)CAAAG upstream-variant-2KB
rs236137 -- 5,909,499(+) TCTTT(C/T)GTGCC upstream-variant-2KB
rs236138 -- 5,909,714(+) ctagt(C/T)acttc upstream-variant-2KB
rs236139 -- 5,910,283(+) CCTCG(C/T)TTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHGB Gene

Variant ID Type Subtype PubMed ID
nsv833905 CNV Gain 17160897
nsv525940 CNV Loss 19592680

Variation tolerance for CHGB Gene

Residual Variation Intolerance Score: 69.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHGB Gene

HapMap Linkage Disequilibrium report
CHGB
Human Gene Mutation Database (HGMD)
CHGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHGB Gene

Disorders for CHGB Gene

MalaCards: The human disease database

(6) MalaCards diseases for CHGB Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
mixed ductal-endocrine carcinoma
glucagonoma
  • glucagonoma syndrome
collagenous colitis
  • microscopic colitis, collagenous type
pheochromocytoma
  • pheochromocytoma, modifier of
von hippel-lindau syndrome
  • von hippel-lindau syndrome, modifier of
- elite association
Search CHGB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHGB

Genetic Association Database (GAD)
CHGB
Human Genome Epidemiology (HuGE) Navigator
CHGB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHGB
genes like me logo Genes that share disorders with CHGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHGB Gene

Publications for CHGB Gene

  1. Chromogranins A and B and secretogranin II as prohormones for regulatory peptides from the diffuse neuroendocrine system. (PMID: 20217490) Helle K.B. (Results Probl Cell Differ 2010) 23 67
  2. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension. (PMID: 20359597) Zhang K. … O'Connor D.T. (J. Am. Coll. Cardiol. 2010) 23 67
  3. Defective secretion of islet hormones in chromogranin-B deficient mice. (PMID: 20126668) ObermA1ller S. … Barg S. (PLoS ONE 2010) 23 67
  4. Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. (PMID: 20007371) Gros-Louis F. … Julien J.P. (Proc. Natl. Acad. Sci. U.S.A. 2009) 23 67
  5. Proteolytic fragments of chromogranins A and B represent major soluble components of chromaffin granules, illustrated by two-dimensional proteomics with NH(2)-terminal Edman peptide sequencing and MALDI-TOF MS. (PMID: 19405523) Lee J.C. … Hook V. (Biochemistry 2009) 23 67

Products for CHGB Gene

Sources for CHGB Gene

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