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Aliases for CHGB Gene

Aliases for CHGB Gene

  • Chromogranin B 2 3 5
  • Secretogranin B 2 3
  • Secretogranin I 3 4
  • SCG1 3 4
  • CGB 3 4
  • SgI 3 4
  • Secretogranin 1 2
  • Secretogranin-1 3
  • Chromogranin-B 4

External Ids for CHGB Gene

Previous HGNC Symbols for CHGB Gene

  • SCG1

Previous GeneCards Identifiers for CHGB Gene

  • GC20P005880
  • GC20P005840
  • GC20P005887
  • GC20P005848

Summaries for CHGB Gene

Entrez Gene Summary for CHGB Gene

  • This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This protein may serve as a precursor for regulatory peptides. [provided by RefSeq, Jan 2009]

GeneCards Summary for CHGB Gene

CHGB (Chromogranin B) is a Protein Coding gene. Diseases associated with CHGB include Mixed Ductal-Endocrine Carcinoma and Glucagonoma. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for CHGB Gene

  • Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

Gene Wiki entry for CHGB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHGB Gene

Genomics for CHGB Gene

Regulatory Elements for CHGB Gene

Enhancers for CHGB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G005861 1.5 Ensembl ENCODE dbSUPER 17.2 -47.2 -47214 4.9 PKNOX1 FOXA2 ZNF133 SIN3A FEZF1 ZNF2 GLIS2 CBX5 GATA2 FOS CHGB RNU1-55P MCM8 TRMT6 C20orf196 GC20P005890
GH20G005845 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.3 -65.0 -65039 2.4 INSM2 KLF17 FEZF1 BMI1 ZBTB40 ZEB1 ZNF366 SCRT2 RELB IKZF2 CHGB RNU1-55P TRMT6 MCM8 GC20P005890 C20orf196
GH20G005834 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -75.4 -75398 3.0 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 SLC30A9 FOS SP5 RNU1-55P CHGB TRMT6 MCM8 GC20P005890 C20orf196
GH20G005843 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -67.3 -67263 1.4 PKNOX1 FOXA2 SIN3A GLIS2 CBX5 FOS ZNF263 SP3 JUNB TSHZ1 RNU1-55P CHGB MCM8 TRMT6 GC20P005890 C20orf196
GH20G005674 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.2 -236.1 -236128 2.4 PKNOX1 FOXA2 ATF1 CREB3L1 ARNT TCF12 ZNF766 CBX5 ELK1 GATA2 GPCPD1 CHGB TRMT6 LOC105372514
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHGB on UCSC Golden Path with GeneCards custom track

Promoters for CHGB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000134124 372 601 HNRNPUL1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143

Genomic Location for CHGB Gene

Chromosome:
20
Start:
5,911,328 bp from pter
End:
5,925,361 bp from pter
Size:
14,034 bases
Orientation:
Plus strand

Genomic View for CHGB Gene

Genes around CHGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHGB Gene

Proteins for CHGB Gene

  • Protein details for CHGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05060-SCG1_HUMAN
    Recommended name:
    Secretogranin-1
    Protein Accession:
    P05060
    Secondary Accessions:
    • A8K021
    • Q59EU9
    • Q6IBS6
    • Q9BQV6
    • Q9UC25
    • Q9UJA6

    Protein attributes for CHGB Gene

    Size:
    677 amino acids
    Molecular mass:
    78276 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD92949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CHGB Gene

Post-translational modifications for CHGB Gene

  • Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity).
  • O-glycosylated.
  • Glycosylation at Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for CHGB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CHGB (Chromogranin B)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CHGB

No data available for DME Specific Peptides for CHGB Gene

Domains & Families for CHGB Gene

Gene Families for CHGB Gene

Protein Domains for CHGB Gene

Suggested Antigen Peptide Sequences for CHGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05060

UniProtKB/Swiss-Prot:

SCG1_HUMAN :
  • Belongs to the chromogranin/secretogranin protein family.
Family:
  • Belongs to the chromogranin/secretogranin protein family.
genes like me logo Genes that share domains with CHGB: view

Function for CHGB Gene

Molecular function for CHGB Gene

GENATLAS Biochemistry:
chromogranin B (catecholamine and norepenephrine secretory protein)
UniProtKB/Swiss-Prot Function:
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.

Gene Ontology (GO) - Molecular Function for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 3608978
GO:0005515 protein binding IPI 20195357
genes like me logo Genes that share ontologies with CHGB: view

Phenotypes for CHGB Gene

genes like me logo Genes that share phenotypes with CHGB: view

Animal Models for CHGB Gene

MGI Knock Outs for CHGB:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHGB

miRNA for CHGB Gene

miRTarBase miRNAs that target CHGB

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHGB Gene

Localization for CHGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHGB Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHGB gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
golgi apparatus 2
plasma membrane 1
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0030141 secretory granule IEA --
genes like me logo Genes that share ontologies with CHGB: view

Pathways & Interactions for CHGB Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with CHGB: view

No data available for Pathways by source and SIGNOR curated interactions for CHGB Gene

Drugs & Compounds for CHGB Gene

(11) Drugs for CHGB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for CHGB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHGB: view

Transcripts for CHGB Gene

mRNA/cDNA for CHGB Gene

Unigene Clusters for CHGB Gene

Chromogranin B (secretogranin 1):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHGB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
SP1: - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6:
SP7: - - - - -

Relevant External Links for CHGB Gene

GeneLoc Exon Structure for
CHGB
ECgene alternative splicing isoforms for
CHGB

Expression for CHGB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHGB Gene

This gene is overexpressed in Pituitary (x18.6), Brain - Cerebellar Hemisphere (x9.1), Brain - Cerebellum (x6.1), and Adrenal Gland (x4.4).

Protein differential expression in normal tissues from HIPED for CHGB Gene

This gene is overexpressed in Cerebrospinal fluid (35.5) and Adrenal (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHGB Gene



NURSA nuclear receptor signaling pathways regulating expression of CHGB Gene:

CHGB

SOURCE GeneReport for Unigene cluster for CHGB Gene:

Hs.516874

mRNA Expression by UniProt/SwissProt for CHGB Gene:

P05060-SCG1_HUMAN
Tissue specificity: Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver.

Evidence on tissue expression from TISSUES for CHGB Gene

  • Nervous system(5)
  • Adrenal gland(4.8)
  • Pancreas(4.7)
  • Lung(4.2)
  • Liver(4)
  • Stomach(2.5)
  • Intestine(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with CHGB: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHGB Gene

Orthologs for CHGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHGB 34 35
  • 99.11 (n)
dog
(Canis familiaris)
Mammalia CHGB 34 35
  • 83.74 (n)
cow
(Bos Taurus)
Mammalia CHGB 34 35
  • 78.6 (n)
mouse
(Mus musculus)
Mammalia Chgb 34 16 35
  • 76.28 (n)
rat
(Rattus norvegicus)
Mammalia Chgb 34
  • 76.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHGB 35
  • 44 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHGB 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHGB 34 35
  • 53.66 (n)
lizard
(Anolis carolinensis)
Reptilia CHGB 35
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19044 34
Species where no ortholog for CHGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CHGB Gene

ENSEMBL:
Gene Tree for CHGB (if available)
TreeFam:
Gene Tree for CHGB (if available)

Paralogs for CHGB Gene

No data available for Paralogs for CHGB Gene

Variants for CHGB Gene

Sequence variations from dbSNP and Humsavar for CHGB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs193921088 Uncertain significance 5,923,452(+) AGAGA(A/C)GAGAA reference, missense
rs1000203594 -- 5,909,921(+) GCGAT(A/C)CACTC upstream-variant-2KB
rs1000245093 -- 5,915,011(+) TTTCA(C/T)GTCTG intron-variant
rs1000255913 -- 5,910,238(+) AAAAG(A/G)ATTTG upstream-variant-2KB
rs1000354322 -- 5,920,751(+) GCCCC(A/G)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHGB Gene

Variant ID Type Subtype PubMed ID
nsv525940 CNV loss 19592680
nsv833905 CNV gain 17160897

Variation tolerance for CHGB Gene

Residual Variation Intolerance Score: 69.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHGB Gene

Human Gene Mutation Database (HGMD)
CHGB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHGB Gene

Disorders for CHGB Gene

MalaCards: The human disease database

(7) MalaCards diseases for CHGB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
mixed ductal-endocrine carcinoma
glucagonoma
  • glucagonoma syndrome
pheochromocytoma
  • pheochromocytoma, modifier of
collagenous colitis
  • microscopic colitis, collagenous type
neuroendocrine tumor
  • neuroendocrine neoplasm
- elite association - COSMIC cancer census association via MalaCards
Search CHGB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHGB

Genetic Association Database (GAD)
CHGB
Human Genome Epidemiology (HuGE) Navigator
CHGB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHGB
genes like me logo Genes that share disorders with CHGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHGB Gene

Publications for CHGB Gene

  1. Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. (PMID: 20007371) Gros-Louis F. … Julien J.P. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 22 46 64
  2. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PMID: 18180394) Fung M.M. … O'Connor D.T. (Circulation 2008) 3 22 46 64
  3. Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population. (PMID: 15219467) Iijima Y. … Arinami T. (Biol. Psychiatry 2004) 3 22 46 64
  4. Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing. (PMID: 1882087) Gill B.M. … O'Connor D.T. (Regul. Pept. 1991) 3 4 22 64
  5. The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region. (PMID: 3608978) Benedum U.M. … Huttner W.B. (EMBO J. 1987) 2 3 4 64

Products for CHGB Gene

Sources for CHGB Gene

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