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CHGB Gene

protein-coding   GIFtS: 59
GCID: GC20P005891

Chromogranin B (Secretogranin 1)


(Previous symbol: SCG1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromogranin B (Secretogranin 1)1 2     secretogranin-12
SCG11 2 3 5     sgI2
Secretogranin B1 2     CgB3
Secretogranin I2 3     Chromogranin-B3
cgB2     SgI3
chromogranin-B2     

External Ids:    HGNC: 19301   Entrez Gene: 11142   Ensembl: ENSG000000891997   OMIM: 1189205   UniProtKB: P050603   

Export aliases for CHGB gene to outside databases

Previous GC identifers: GC20P005880 GC20P005840 GC20P005887 GC20P005848


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHGB Gene:
This gene encodes a tyrosine-sulfated secretory protein abundant in peptidergic endocrine cells and neurons. This
protein may serve as a precursor for regulatory peptides. (provided by RefSeq, Jan 2009)

GeneCards Summary for CHGB Gene:
CHGB (chromogranin B (secretogranin 1)) is a protein-coding gene. Diseases associated with CHGB include female breast carcinoma, and silent pituitary adenoma. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot: SCG1_HUMAN, P05060
Function: Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other
biologically active peptides

Gene Wiki entry for CHGB (Secretoneurin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHGB gene promoter:
         AP-1   AP-2alpha isoform 3   AML1a   NRSF form 1   AP-2alpha isoform 2   NRSF form 2   AP-2alpha isoform 4   AP-2alpha   RSRFC4   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHGB promoter sequence
   Search Chromatin IP Primers for CHGB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p12.3   Ensembl cytogenetic band:  20p12.3   HGNC cytogenetic band: 20p12.3

CHGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHGB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P005891:  view genomic region     (about GC identifiers)

Start:
5,891,974 bp from pter      End:
5,906,007 bp from pter
Size:
14,034 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: SCG1_HUMAN, P05060 (See protein sequence)
Recommended Name: Secretogranin-1 precursor  
Size: 677 amino acids; 78276 Da
Sequence caution: Sequence=BAD92949.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K021 Q59EU9 Q6IBS6 Q9BQV6 Q9UC25 Q9UJA6

Explore the universe of human proteins at neXtProt for CHGB: NX_P05060

Explore proteomics data for CHGB at MOPED

Post-translational modifications: 

  • Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in
    different tissues (By similarity)1
  • O-glycosylated1
  • Glycosylation2 at Asn315
  • Modification sites at PhosphoSitePlus

  • See CHGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001810.2  
    ENSEMBL proteins: 
     ENSP00000368244   ENSP00000416643  

    CHGB Human Recombinant Protein Products:

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    OriGene Custom MassSpec
    OriGene Custom Protein Services for CHGB
    GenScript Custom Purified and Recombinant Proteins Services for CHGB
    Novus Biologicals CHGB Protein
    Novus Biologicals CHGB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CHGB
    Cloud-Clone Corp. Proteins for CHGB

    CHGB Antibody Products:

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    Abcam antibodies for CHGB
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    LSBio Antibodies in human, mouse, rat for CHGB

    CHGB Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHGB
    Cloud-Clone Corp. CLIAs for CHGB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001819 Chromogranin_AB
     IPR018054 Chromogranin_CS
     IPR001990 Granin

    Graphical View of Domain Structure for InterPro Entry P05060

    ProtoNet protein and cluster: P05060

    1 Blocks protein domain: IPB001990 Chromogranin/secretogranin

    UniProtKB/Swiss-Prot: SCG1_HUMAN, P05060
    Similarity: Belongs to the chromogranin/secretogranin protein family


    CHGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: SCG1_HUMAN, P05060
    Function: Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other
    biologically active peptides

         Genatlas biochemistry entry for CHGB:
    chromogranin B (catecholamine and norepenephrine secretory protein)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity TAS3608978
    GO:0005515protein binding IPI--
         
    CHGB for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chgb):
     endocrine/exocrine gland  homeostasis/metabolism  nervous system 

    CHGB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CHGB: Chgbtm1Wbh Chgbtm1Ribo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHGB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHGB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHGB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHGB

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHGB:
    hsa-mir-375 (MIRT019922)

    Block miRNA regulation of human, mouse, rat CHGB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CHGB
    SwitchGear 3'UTR luciferase reporter plasmidCHGB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHGB
    Predesigned siRNA for gene silencing in human, mouse, rat CHGB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHGB

    Clone
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    OriGene clones in human, mouse for CHGB (see all 6)
    OriGene ORF clones in mouse, rat for CHGB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHGB (NM_001819)
    Sino Biological Human cDNA Clone for CHGB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHGB

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHGB
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHGB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHGB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    SCG1_HUMAN, P05060: Secreted. Note=Neuroendocrine and endocrine secretory granules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum2
    cytoskeleton1
    cytosol1
    golgi apparatus1
    lysosome1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030141secretory granule IEA--

    CHGB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CHGB: 
              Parkinson's Disease in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CHGB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for CHGB (P050601, 2, 3 ENSP000003682444) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTENP604842, 3, ENSP000003610214MINT-63918 I2D: score=5 STRING: ENSP00000361021
    TUBB2AQ138852, 3, ENSP000003697034MINT-64589 I2D: score=3 STRING: ENSP00000369703
    RAC2P151532, 3, ENSP000002490714MINT-8267918 I2D: score=2 STRING: ENSP00000249071
    ATXN2Q997002, 3MINT-65287 I2D: score=5 
    CBFBQ139512, 3MINT-65560 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHGB (SCG1)

    Selected Novoseek inferred chemical compound relationships for CHGB gene (see all 17)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    secretoneurin 92.1 20 11931350 (3), 9891437 (2), 14724070 (2), 18448176 (2) (see all 12)
    peptidylglycine 57.3 1 7865135 (1)
    inositol 1,4,5 trisphosphate 42.6 7 12438140 (1), 17395556 (1), 18020452 (1), 18420944 (1) (see all 5)
    catecholamine 36.3 8 20359597 (2), 15138309 (1), 18180394 (1), 14637105 (1)
    dithiothreitol 26.8 15 8491204 (4), 7834494 (3), 10409115 (2), 8082769 (2)
    oligonucleotide 13.9 2 7551295 (1)
    calcium 8.98 22 8663344 (4), 18020452 (1), 18420944 (1), 17997581 (1) (see all 10)
    norepinephrine 0.612 1 8978502 (1)
    sucrose 0 1 9535898 (1)
    threonine 0 2 1601888 (1)



    CHGB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHGB gene: 
    NM_001819.2  

    Unigene Cluster for CHGB:

    Chromogranin B (secretogranin 1)
    Hs.516874  [show with all ESTs]
    Unigene Representative Sequence: NM_001819
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378961(uc002wmg.3 uc010zqz.2) ENST00000455042 ENST00000488832

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHGB using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CHGB
    SwitchGear 3'UTR luciferase reporter plasmidCHGB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHGB
    Predesigned siRNA for gene silencing in human, mouse, rat CHGB
    Clone
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    OriGene clones in human, mouse for CHGB (see all 6)
    OriGene ORF clones in mouse, rat for CHGB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHGB (NM_001819)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHGB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHGB
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHGB
    OriGene qSTAR qPCR primer pairs in human, mouse for CHGB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHGB
      QuantiTect SYBR Green Assays in human, mouse, rat CHGB
      QuantiFast Probe-based Assays in human, mouse, rat CHGB

    Additional mRNA sequence: 

    AB209712.1 AK054871.1 AK225125.1 AK289386.1 AK293536.1 AK312237.1 BC000375.2 CR456726.1 
    Y00064.1 

    13 DOTS entries:

    DT.117082  DT.100877878  DT.100877870  DT.100877876  DT.95077028  DT.95288716  DT.100877885  DT.100877887 
    DT.120811216  DT.91945588  DT.95070611  DT.92445291  DT.95070612 

    Selected AceView cDNA sequences (see all 377):

    CA949929 BM681923 BI712493 BU073302 BQ417412 BU947569 AA679125 BG656520 
    AA319410 AA319567 R39078 AA584885 CD251136 AA318621 BQ130625 BM508066 
    BU789210 BM565579 CA776205 BX110297 AI150171 BM857542 BC000375 BM930895 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHGB (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b
    SP1:                                -     -                                                         
    SP2:                                      -                 -                                       
    SP3:                                -     -                 -                                       
    SP4:                                                        -                                       
    SP5:                          -     -     -     -           -                                       


    ECgene alternative splicing isoforms for CHGB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATGACAA
    CHGB Expression
    About this image


    CHGB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Eye (Sensory Organs)
             Retina
     
     Adrenal Gland (Endocrine System)
    CHGB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHGB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516874

    UniProtKB/Swiss-Prot: SCG1_HUMAN, P05060
    Tissue specificity: Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver

        Pathway & Disease-focused RT2 Profiler PCR Array including CHGB: 
              Parkinson's Disease in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHGB
    OriGene qSTAR qPCR primer pairs in human, mouse for CHGB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHGB
    QuantiTect SYBR Green Assays in human, mouse, rat CHGB
    QuantiFast Probe-based Assays in human, mouse, rat CHGB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHGB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CHGB gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chgb1 , 5 chromogranin B1, 5 76.28(n)1
    65.71(a)1
      2 (64.74 cM)5
    126531  NM_007694.41  NP_031720.11 
     1327812785 
    chicken
    (Gallus gallus)
    Aves CHGB1 chromogranin B (secretogranin 1) 53.66(n)
    38.54(a)
      421312  XM_419377.4  XP_419377.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHGB6
    chromogranin B (secretogranin 1)
    22(a)
    1 ↔ 1
    AAWZ02036810(5056-21166)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.190442 Transcribed sequence with weak similarity to protein more 71.47(n)    BX773071.1 


    ENSEMBL Gene Tree for CHGB (if available)
    TreeFam Gene Tree for CHGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHGB (see all 468)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs568479611,2
    C,F--5890001(+) TCAGCG/ACATCT 1 -- us2k11Minor allele frequency- A:0.16WA 118
    rs1408166301,2
    --5890063(+) TGCAGA/TTCTGC 1 -- us2k10--------
    rs2361361,2
    C,F,O,A,H--5890071(+) TGCAGC/TCAAAG 1 -- us2k1 tfbs312Minor allele frequency- T:0.45NA WA CSA EA 686
    rs1156995921,2
    C,F--5890134(+) TTTAAA/GCAGAC 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs2361371,2
    C,F,A,H--5890145(+) TCTTTC/TGTGCC 1 -- us2k122Minor allele frequency- T:0.42NS EA NA WA CSA 2399
    rs730831881,2
    C,F--5890247(+) TTCCCT/CGAATG 1 -- us2k12Minor allele frequency- C:0.03WA NA 238
    rs1152337661,2
    F--5890329(+) AGGAAG/ATTGTA 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs2361381,2
    C,F,H--5890360(+) ctagtT/Cacttc 1 -- us2k116Minor allele frequency- C:0.15NS EA NA WA CSA 768
    rs1853439551,2
    --5890410(+) ATCACA/GGTACA 1 -- us2k10--------
    rs61398681,2
    C,A--5890457(+) CTTTTC/TTTTCT 1 -- us2k1 trp34Minor allele frequency- T:0.12NA WA CSA 8

    HapMap Linkage Disequilibrium report for CHGB (5891974 - 5906007 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHGB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv525940CNV Loss19592680
    nsv833905CNV Gain17160897

    Human Gene Mutation Database (HGMD): CHGB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHGB
    DNA2.0 Custom Variant and Variant Library Synthesis for CHGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118920    OMIM disorders: --

    Selected diseases for CHGB (see all 39):    
    About MalaCards
    female breast carcinoma    silent pituitary adenoma    glucagonoma    parathyroid adenoma
    phaeochromocytoma    prolactinoma    neuroendocrine tumor    paraganglioma
    pheochromocytoma    prostate adenocarcinoma    pancreatic endocrine tumors    multiple endocrine neoplasia
    temporal lobe epilepsy    neuroendocrine carcinoma    pituitary adenoma    pituitary tumors
    frontotemporal dementia    neurologic diseases    adenoma    primitive neuroectodermal tumor


    CHGB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CHGB gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoid 63.9 19 7891024 (2), 9891437 (2), 7599788 (2), 1856109 (1) (see all 9)
    neuroendocrine tumors 60.5 6 1928556 (1), 7551295 (1), 10697270 (1)
    pheochromocytoma 55.9 15 1882087 (3), 15601318 (3), 9037129 (2), 1437706 (1) (see all 8)
    pituitary adenoma 48.6 6 1552186 (2), 8396420 (2), 8669489 (1), 1928557 (1)
    prolactinoma 45.7 3 1342950 (1), 2294779 (1)
    multiple endocrine neoplasia 45.3 2 7891024 (1), 17639059 (1)
    glucagonoma 43.9 6 1954895 (4), 7952497 (1)
    thyroid carcinoma medullary 39.1 3 9664908 (1), 19215381 (1)
    adenoma 35 17 8396420 (3), 14586070 (2), 7680355 (2), 8669489 (2) (see all 7)
    parathyroid adenoma 33.9 3 1342950 (1), 2294779 (1)

    Genetic Association Database (GAD): CHGB
    Human Genome Epidemiology (HuGE) Navigator: CHGB (11 documents)

    Export disorders for CHGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHGB gene, integrated from 10 sources (see all 211):
    (articles sorted by number of sources associating them with CHGB)
        Utopia: connect your pdf to the dynamic
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    1. The primary structure of human secretogranin I (chromogranin B): comparison with chromogranin A reveals homologous terminal domains and a large intervening variable region. (PubMed id 3608978)1, 2, 3 Benedum U.M.... Huttner W.B. (EMBO J. 1987)
    2. Chromogranin B: isolation from pheochromocytoma, N-terminal sequence, tissue distribution and secretory vesicle processing. (PubMed id 1882087)1, 2, 9 Gill B.M.... O'Connor D.T. (Regul. Pept. 1991)
    3. Association between chromogranin b gene polymorphisms and schizophrenia in the Japanese population. (PubMed id 15219467)1, 4, 9 Iijima Y....Arinami T. (Biol. Psychiatry 2004)
    4. Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. (PubMed id 20007371)1, 4, 9 Gros-Louis F....Julien J.P. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. (PubMed id 18180394)1, 4, 9 Fung M.M....O'Connor D.T. (Circulation 2008)
    6. Identification and characterization of phosphorylated proteins in the human pituitary. (PubMed id 14997482)1, 2, 9 Giorgianni F.... Desiderio D.M. (Proteomics 2004)
    7. Polymorphisms of chromogranin B gene associated with schizophrenia in Chinese Han population. (PubMed id 11959426)1, 4, 9 Zhang B....He L. (Neurosci. Lett. 2002)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. P413L CHGB is not associated with ALS susceptibility or age at onset in a Dutch population. (PubMed id 20431044)1, 4 van Vught P.W....van den Berg L.H. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    10. Autonomic function in hypertension; role of genetic variation at the catecholamine storage vesicle protein chromogranin B. (PubMed id 20011129)1, 4 Zhang K....O'Connor D.T. (Circ Cardiovasc Genet 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1114 HGNC: 1930 AceView: CHGB Ensembl:ENSG00000089199 euGenes: HUgn1114
    ECgene: CHGB H-InvDB: CHGB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHGB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHGB gene:
    Search GeneIP for patents involving CHGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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