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CHGA Gene

protein-coding   GIFtS: 65
GCID: GC14P093389

Chromogranin A (Parathyroid Secretory Protein 1)

  See CHGA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromogranin A (Parathyroid Secretory Protein 1)1 2     CGA2
Pituitary Secretory Protein I2 3     Betagranin (N-Terminal Fragment Of Chromogranin A)2
SP-I2 3     chromogranin-A2
pancreastatin1     Parathyroid Secretory Protein 12
parastatin1     CgA3
vasostatin1     

External Ids:    HGNC: 19291   Entrez Gene: 11132   Ensembl: ENSG000001006047   OMIM: 1189105   UniProtKB: P106453   

Export aliases for CHGA gene to outside databases

Previous GC identifers: GC14P090896 GC14P087206 GC14P091379 GC14P092459 GC14P073571


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHGA Gene:
The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory
proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to
three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or
paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin,
WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these
molecules have not been shown. (provided by RefSeq, Jul 2008)

GeneCards Summary for CHGA Gene:
CHGA (chromogranin A (parathyroid secretory protein 1)) is a protein-coding gene. Diseases associated with CHGA include cushing's syndrome, and gastric small cell carcinoma.

UniProtKB/Swiss-Prot: CMGA_HUMAN, P10645
Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas

Gene Wiki entry for CHGA (Chromogranin A) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NT_187601.1  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHGA gene promoter:
         CREB   Sp1   deltaCREB   NRSF form 1   Msx-1   NRSF form 2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHGA promoter sequence
   Search Chromatin IP Primers for CHGA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHGA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32

CHGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHGA gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P093389:  view genomic region     (about GC identifiers)

Start:
93,389,425 bp from pter      End:
93,401,638 bp from pter
Size:
12,214 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CMGA_HUMAN, P10645 (See protein sequence)
Recommended Name: Chromogranin-A precursor  
Size: 457 amino acids; 50688 Da
Subunit: Interacts with SCG3 (By similarity)
Miscellaneous: Binds calcium with a low-affinity
1 PDB 3D structure from and Proteopedia for CHGA:
1LV4 (3D)    
Secondary accessions: B2R9E9 Q53FA8 Q6NR84 Q96E84 Q96GL7 Q9BQB5

Explore the universe of human proteins at neXtProt for CHGA: NX_P10645

Explore proteomics data for CHGA at MOPED

Post-translational modifications: 

  • Sulfated on tyrosine residues and/or contains sulfated glycans1
  • O-glycosylated with core 1 or possibly core 8 glycans1
  • Glycosylation2 at Asn110, Thr181, Thr183, Thr251
  • Modification sites at PhosphoSitePlus

  • See CHGA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001266.1  
    ENSEMBL proteins: 
     ENSP00000216492   ENSP00000450801   ENSP00000334023  

    CHGA Human Recombinant Protein Products:

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    Novus Biologicals CHGA Proteins
    Novus Biologicals CHGA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CHGA
    Cloud-Clone Corp. Proteins for CHGA

     
    Search eBioscience for Proteins for CHGA 

    CHGA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CHGA
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHGA
    Cloud-Clone Corp. CLIAs for CHGA
    Search eBioscience for ELISAs for CHGA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001819 Chromogranin_AB
     IPR018054 Chromogranin_CS
     IPR001990 Granin

    Graphical View of Domain Structure for InterPro Entry P10645

    ProtoNet protein and cluster: P10645

    1 Blocks protein domain: IPB001990 Chromogranin/secretogranin

    UniProtKB/Swiss-Prot: CMGA_HUMAN, P10645
    Similarity: Belongs to the chromogranin/secretogranin protein family


    Find genes that share domains with CHGA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CMGA_HUMAN, P10645
    Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas

         Genatlas biochemistry entry for CHGA:
    chromogranin A (peptide hormones and neurotransmitters secretory protein I;precursor of pancreastatin and
    vasostatin),overexpressed in sporadic endocrine tumors inflammatory,bowel disease,non endocrine pancreatic
    disease

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CHGA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CHGA:
     Decreased viability of wild-ty 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chga):
     cardiovascular system  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  mortality/aging 
     renal/urinary system  reproductive system 

    Find genes that share phenotypes with CHGA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CHGA: Chgatm1Skmt Chgatm1Gnh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHGA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHGA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHGA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHGA

    miRNA
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    miRTarBase miRNAs that target CHGA:
    hsa-mir-335-5p (MIRT018742)

    Block miRNA regulation of human, mouse, rat CHGA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHGA (see all 16):
    hsa-miR-124* hsa-miR-320a hsa-miR-137 hsa-miR-25 hsa-miR-92b hsa-miR-22 hsa-miR-577 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidCHGA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CHGA
    Predesigned siRNA for gene silencing in human, mouse, rat CHGA

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CHGA (NM_001275)
    Sino Biological Human cDNA Clone for CHGA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHGA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHGA

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHGA

    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-13875) for CHGA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CMGA_HUMAN, P10645: Cytoplasmic vesicle, secretory vesicle lumen (By similarity). Cytoplasmic vesicle, secretory
    vesicle membrane (By similarity). Secreted. Note=Associated with the secretory granule membrane through direct
    interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytoskeleton3
    cytosol2
    nucleus2
    plasma membrane2
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0030141secretory granule IEA--
    GO:0030658transport vesicle membrane IEA--
    GO:0048471perinuclear region of cytoplasm IDA--

    Find genes that share ontologies with CHGA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHGA About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of CREB1
    Selected targets of CREB1

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CHGA
        GnRH Signaling



        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHGA: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CHGA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CHGA (P106452, 3 ENSP000002164924) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC37Q165432, 3MINT-8250822 I2D: score=2 
    NEK2P519552, 3MINT-8263643 I2D: score=2 
    PFDN1O609252, 3MINT-8265742 I2D: score=2 
    CHGBP050603, ENSP000003682444I2D: score=1 STRING: ENSP00000368244
    SCG3Q8WXD23, ENSP000002204784I2D: score=1 STRING: ENSP00000220478
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008217regulation of blood pressure TAS8406464

    Find genes that share ontologies with CHGA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHGA (CMGA)

    1 HMDB Compound for CHGA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for CHGA gene (see all 122)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    secretoneurin 83.1 41 9891437 (4), 10999531 (4), 7952497 (4), 7535395 (3) (see all 21)
    zm 336372 73.5 2 18299943 (1), 16603190 (1)
    111in-pentetreotide 72.7 12 16231013 (4), 16917396 (1), 18765956 (1), 19561636 (1) (see all 6)
    octreotide 68.1 39 17578828 (5), 19337629 (4), 17274678 (3), 17003646 (3) (see all 15)
    catecholamine 64.9 90 11342539 (4), 7700724 (3), 12920656 (3), 1681748 (3) (see all 40)
    smcc 59.2 1 18008084 (1)
    lanreotide 53.4 5 11351350 (3), 12920656 (1)
    acth 49.4 37 1928557 (2), 8396420 (2), 2117315 (1), 8606042 (1) (see all 30)
    5-hydroxyindoleacetic acid 48 47 15161793 (6), 7547218 (6), 18209781 (4), 10463986 (3) (see all 16)
    paraffin 47.8 14 1654075 (1), 17614779 (1), 8162254 (1), 10792483 (1) (see all 13)



    Find genes that share compounds with CHGA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHGA gene: 
    NM_001275.3  

    Unigene Cluster for CHGA:

    Chromogranin A (parathyroid secretory protein 1)
    Hs.150793  [show with all ESTs]
    Unigene Representative Sequence: NM_001275
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216492(uc001ybc.4 uc001ybd.4) ENST00000556076 ENST00000334654
    ENST00000553866 ENST00000556098 ENST00000556876
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CHGA (see all 16):
    hsa-miR-124* hsa-miR-320a hsa-miR-137 hsa-miR-25 hsa-miR-92b hsa-miR-22 hsa-miR-577 hsa-miR-92a
    SwitchGear 3'UTR luciferase reporter plasmidCHGA 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: CHGA (NM_001275)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CHGA
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA6-13875) for CHGA 

    Additional mRNA sequence: 

    AK223381.1 AK313757.1 BC001059.2 BC006459.1 BC009384.2 BC012755.2 BC106953.1 BT006869.1 
    BX248263.1 J03483.1 

    15 DOTS entries:

    DT.448614  DT.92452247  DT.100649357  DT.75161899  DT.100799484  DT.100873807  DT.120743784  DT.40123857 
    DT.100873808  DT.100873811  DT.120743772  DT.319042  DT.40123858  DT.91712465  DT.95279114 

    Selected AceView cDNA sequences (see all 366):

    CR596293 BX464893 BU580000 CD106587 CD108140 CR598626 BQ072205 AV703669 
    CR623696 NM_001275 BX404028 BQ070970 CR602096 BP349630 AA318960 AW470949 
    CR623573 Z39925 CR599984 BQ720211 CR613413 CR616206 CD108264 CR593864 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CHGA    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
    SP1:                          -                                                         
    SP2:                          -                             -     -                     
    SP3:                    -     -                                                         
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for CHGA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHGA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTCTCCT
    CHGA Expression
    About this image


    CHGA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 7 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud
             Islets of Langerhans
             Pancreatic endoderm/endocrine precursor-like cells
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
             Midbrain dopaminergic-like neurons
     
     Testis (Reproductive System)
             XY Germ Cells Testis Cord
     
     Neurons
             Midbrain dopaminergic-like neurons
     
     Gonad
             XY Germ Cells Testis Cord
    CHGA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHGA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.150793
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHGA: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHGA
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    QuantiFast Probe-based Assays in human, mouse, rat CHGA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHGA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CHGA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chga1 , 5 chromogranin A1, 5 76.02(n)1
    71.46(a)1
      12 (51.66 cM)5
    126521  NM_007693.11  NP_031719.11 
     1025549695 
    chicken
    (Gallus gallus)
    Aves CHGA6
    chromogranin A (parathyroid secretory protein 1)
    43(a)
    1 ↔ 1
    5(44155021-44165632)
    lizard
    (Anolis carolinensis)
    Reptilia CHGA6
    chromogranin A (parathyroid secretory protein 1)
    40(a)
    1 ↔ 1
    1(11127559-11153033)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.15622 Xenopus laevis transcribed sequence with weak similarity more 80.51(n)    BG346667.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chga6
    chromogranin A
    31(a)
    1 ↔ 1
    20(27049808-27075598) ENSDARG00000008829


    ENSEMBL Gene Tree for CHGA (if available)
    TreeFam Gene Tree for CHGA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for CHGA (see all 414)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502443091,2
    Cuntested193397681(+) CAGACA/GGAGCC 2 R G mis10--------
    rs71473351,2
    C,F,A--93387482(+) CAAGAT/CACTGA 1 -- us2k111Minor allele frequency- C:0.19NA WA CSA EA 372
    rs113646401,2
    C--93387494(+) AGTGA-/TTTTTT 1 -- us2k12Minor allele frequency- T:0.25NA CSA 4
    rs65753031,2
    C,F,H--93387559(+) gggcaC/Taattc 1 -- us2k113Minor allele frequency- T:0.14NA WA CSA EA 380
    rs1495239351,2
    --93387625(+) GAACTC/TTTTCA 1 -- us2k10--------
    rs1118307951,2
    C--93387652(+) ACCCAC/TGAAAC 1 -- us2k12Minor allele frequency- T:0.33WA CSA 3
    rs106591301,2
    C--93387662(+) actaaCTCT/-  
            
    ctgtt
    1 -- us2k1 tfbs31Minor allele frequency- -:0.00CSA 2
    rs671329001,2
    C--93387663(+) CTAAC-/CCT   
      C
    /CTCT
    TGTTT
    1 -- us2k10--------
    rs669288811,2
    C--93387664(+) TAACT-/CCT   
      C
    /CTCT
    GTTTC
    1 -- us2k11NA 2
    rs1998968131,2
    C--93387667(-) GAGGAA/GACAGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHGA (93389425 - 93401638 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CHGA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749027CNV Deletion23290073
    nsv902203CNV Loss21882294
    nsv902202CNV Loss21882294
    nsv902200CNV Loss21882294
    nsv85624CNV Loss16902084
    nsv902201CNV Loss21882294
    nsv1400CNV Loss18451855

    Human Gene Mutation Database (HGMD): CHGA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHGA
    DNA2.0 Custom Variant and Variant Library Synthesis for CHGA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118910    OMIM disorders: --

    Selected diseases for CHGA (see all 53):    
    About MalaCards
    cushing's syndrome    gastric small cell carcinoma    autoimmune atrophic gastritis    lymphocytic colitis
    neuroendocrine tumor    tubular adenocarcinoma    goblet cell carcinoid    large cell carcinoma
    non-secreting paraganglioma    atrophic gastritis    islet cell tumor    small cell carcinoma
    acinar cell carcinoma    cutaneous neuroendocrine carcinoma    small cell neuroendocrine carcinoma    gastrointestinal neuroendocrine tumor
    malignant peripheral nerve sheath tumor    pancreatoblastoma    neuroendocrine carcinoma    female breast carcinoma

    12 diseases from the University of Copenhagen DISEASES database for CHGA:
    Neuroendocrine tumor     Carcinoma     Prostate cancer     Adenoma
    Lung cancer     Merkel cell carcinoma     Gastritis     Pancreatic cancer
    Thyroid cancer     Phaeochromocytoma     Wermer syndrome     Diarrhea

    Find genes that share disorders with CHGA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CHGA gene (see all 98)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoid 91.4 245 15757862 (7), 16432362 (7), 1856109 (6), 18535873 (6) (see all 99)
    neuroendocrine tumors 90.3 173 9253344 (4), 10569138 (3), 19845257 (3), 1413839 (3) (see all 92)
    carcinoma neuroendocrine 89.3 23 8837344 (2), 14533935 (1), 11353063 (1), 18726606 (1) (see all 18)
    small cell lung cancer 79.3 41 10460660 (3), 16159442 (2), 11288956 (2), 1315401 (2) (see all 29)
    paraganglioma 76.4 15 7599788 (2), 8058707 (1), 17614779 (1), 2188235 (1) (see all 12)
    tumors 76.4 792 15053236 (6), 12872342 (6), 17599769 (6), 16188147 (5) (see all 99)
    pheochromocytoma 76 172 15850005 (10), 1988765 (7), 16918946 (7), 11116123 (6) (see all 52)
    thyroid carcinoma medullary 73.7 29 9664908 (3), 18629788 (2), 11259096 (2), 1356053 (2) (see all 16)
    prostatic adenocarcinoma 72.9 20 17285592 (3), 17914093 (2), 18204237 (2), 14990610 (2) (see all 11)
    gastrinoma 72.6 22 8323758 (4), 11204811 (3), 12872342 (2), 12144588 (1) (see all 13)

    Genetic Association Database (GAD): CHGA
    Human Genome Epidemiology (HuGE) Navigator: CHGA (9 documents)

    Export disorders for CHGA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHGA gene, integrated from 10 sources (see all 1490):
    (articles sorted by number of sources associating them with CHGA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA. (PubMed id 3403545)1, 2, 3 Helman L.J.... Israel M.A. (J. Biol. Chem. 1988)
    2. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. (PubMed id 17438154)1, 4, 9 Rao F....O'Connor D.T. (Circulation 2007)
    3. Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. (PubMed id 14740315)1, 2, 9 Wen G.... Hamilton B.A. (Am. J. Hum. Genet. 2004)
    4. Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A. (PubMed id 14759560)1, 2, 9 Preece N.E.... O'Connor D.T. (Regul. Pept. 2004)
    5. Isolation and characterization of a tumor-derived human protein related to chromogranin A and its in vitro conversion to human pancreastatin-48. (PubMed id 2165909)1, 2, 9 Tamamura H.... Funakoshi S. (Eur. J. Biochem. 1990)
    6. Chromogranin A polymorphisms are associated with hypertensive renal disease. (PubMed id 18235090)1, 4, 9 Salem R.M....O'Connor D.T. (J. Am. Soc. Nephrol. 2008)
    7. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. (PubMed id 19017515)1, 4, 9 Chen Y....O'Connor D.T. (J. Am. Coll. Cardiol. 2008)
    8. Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. (PubMed id 17438153)1, 4, 9 Lillie E.O....O'Connor D.T. (Circulation 2007)
    9. Identification and characterization of phosphorylated proteins in the human pituitary. (PubMed id 14997482)1, 2, 9 Giorgianni F.... Desiderio D.M. (Proteomics 2004)
    10. The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy. (PubMed id 12442257)1, 2, 9 Orr D.F.... Shaw C. (Proteomics 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1113 HGNC: 1929 AceView: CHGA Ensembl:ENSG00000100604 euGenes: HUgn1113
    ECgene: CHGA H-InvDB: CHGA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHGA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHGA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHGA gene:
    Search GeneIP for patents involving CHGA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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