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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CHGA Gene

protein-coding GIFtS: 63
GCID: GC14P093389

chromogranin A (parathyroid secretory protein 1)

Explore 192 diseases affiliated with
CHGA via

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromogranin A (Parathyroid Secretory Protein 1)¹ ²		Betagranin (N-Terminal Fragment Of Chromogranin A)²
Pituitary Secretory Protein I² ³		Chromogranin-A¹
SP-I² ³		Parathyroid Secretory Protein 1²
CGA²		CgA³

External Ids:	HGNC: 1929¹	Entrez Gene: 1113²	Ensembl: ENSG00000100604⁷	OMIM: 118910⁵	UniProtKB: P10645³

Export aliases for CHGA gene to outside databases

Previous GC identifers: GC14P090896 GC14P087206 GC14P091379 GC14P092459 GC14P073571

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHGA:

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory

proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three

biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine

negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and

GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been

shown. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CMGA_HUMAN, P10645

Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas

Gene Wiki entry for CHGA (Chromogranin A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CHGA gene promoter:
CREB Sp1 deltaCREB NRSF form 1 Msx-1 NRSF form 2 Roaz
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHGA promoter sequence

Search SABiosciences Chromatin IP Primers for CHGA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHGA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q32

CHGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHGA gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P093389: view genomic region (about GC identifiers)

Start:	93,389,425 bp from pter	End:	93,401,638 bp from pter
Size:	12,214 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CMGA_HUMAN, P10645 (See protein sequence)

Recommended Name: Chromogranin-A precursor

Size: 457 amino acids; 50688 Da

Subunit: Interacts with SCG3 (By similarity)

Subcellular location: Cytoplasmic vesicle, secretory vesicle lumen (By similarity). Cytoplasmic vesicle, secretory

vesicle membrane (By similarity). Secreted. Note=Associated with the secretory granule membrane through direct

interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions (By similarity)

Miscellaneous: Binds calcium with a low-affinity

1 PDB 3D structure from and Proteopedia for CHGA:

1LV4 (3D)

Secondary accessions: B2R9E9 Q53FA8 Q6NR84 Q96E84 Q96GL7 Q9BQB5

Explore the universe of human proteins at neXtProt for CHGA: NX_P10645

Post-translational modifications:

Sulfated on tyrosine residues and/or contains sulfated glycans¹

O-glycosylated with core 1 or possibly core 8 glycans¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P10645

CHGA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001266.1

ENSEMBL proteins:

ENSP00000216492 ENSP00000450801 ENSP00000452293 ENSP00000334023

Human Recombinant Protein Products:

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	Novus Biologicals CHGA Proteins Novus Biologicals CHGA Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CHGA
	Uscn Proteins for CHGA

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0030141	secretory granule	IEA	--
GO:0030658	transport vesicle membrane	IEA	--

CHGA for ontologies About GeneDecksing

CHGA Antibody Products:

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	ThermoFisher Antibody for CHGA

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	Uscn ELISAs and CLIAs for CHGA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHGA for domains About GeneDecksing

3 InterPro domains/families:

IPR001819 Chromogranin_AB

IPR018054 Chromogranin_CS

IPR001990 Granin

Graphical View of Domain Structure for InterPro Entry P10645

ProtoNet protein and cluster: P10645

1 Blocks protein family: IPB001990 Chromogranin/secretogranin

UniProtKB/Swiss-Prot: CMGA_HUMAN, P10645

Similarity: Belongs to the chromogranin/secretogranin protein family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CMGA_HUMAN, P10645

Function: Pancreastatin strongly inhibits glucose induced insulin release from the pancreas

Genatlas biochemistry entry for CHGA:

chromogranin A (peptide hormones and neurotransmitters secretory protein I;precursor of pancreastatin and

vasostatin),overexpressed in sporadic endocrine tumors inflammatory,bowel disease,non endocrine pancreatic disease

miRNA Products:		OriGene 3'-UTR Clone: CHGA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHGA
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CHGA (see all 16):
		hsa-miR-124* hsa-miR-320a hsa-miR-137 hsa-miR-25 hsa-miR-92b hsa-miR-22 hsa-miR-577 hsa-miR-92a

		SwitchGear 3'UTR luciferase reporter plasmid: CHGA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHGA (see all 7) OriGene shRNA RFP: CHGA OriGene siRNA: CHGA
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CHGA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CHGA (NM_001275)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHGA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CHGA
		Search LifeMap BioReagents cell lines for CHGA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHGA

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--

CHGA for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CHGA:

Decreased viability of wild-ty

Animal Models:
Mouse knock-outs for CHGA: Chga^tm1Skmt Chga^tm1Gnh
7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Chga):

cardiovascular system	endocrine/exocrine gland	growth/size	homeostasis/metabolism	mortality/aging
renal/urinary system	reproductive system

CHGA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Selected targets of CREB1

Selected targets of CREB1

1.00

Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CHGA

Selected targets of CREB1

1 PharmGKB Pathway for CHGA

Sympathetic Nerve Pathway (Pre- and Post- Ganglionic Junction)

CHGA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CHGA

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/8 Interacting proteins for CHGA (P10645^{2, 3} ENSP00000216492⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC37	Q16543²^,³	MINT-8250822 I2D: score=2
NEK2	P51955²^,³	MINT-8263643 I2D: score=2
PFDN1	O60925²^,³	MINT-8265742 I2D: score=2
CHGB	P05060³, ENSP00000368244⁴	I2D: score=1 STRING: ENSP00000368244
SCG3	Q8WXD2³, ENSP00000220478⁴	I2D: score=1 STRING: ENSP00000220478

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008217	regulation of blood pressure	TAS	8406464

CHGA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CHGA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHGA

1 HMDB Compound for CHGA About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

10/122 Novoseek chemical compound relationships for CHGA gene (see all 122) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
secretoneurin	83.1	41	9891437 (4), 10999531 (4), 7952497 (4), 7535395 (3) (see all 21)
zm 336372	73.5	2	18299943 (1), 16603190 (1)
111in-pentetreotide	72.7	12	16231013 (4), 16917396 (1), 18765956 (1), 19561636 (1) (see all 6)
octreotide	68.1	39	17578828 (5), 19337629 (4), 17274678 (3), 17003646 (3) (see all 15)
catecholamine	64.9	90	11342539 (4), 7700724 (3), 12920656 (3), 1681748 (3) (see all 40)
smcc	59.2	1	18008084 (1)
lanreotide	53.4	5	11351350 (3), 12920656 (1)
acth	49.4	37	1928557 (2), 8396420 (2), 2117315 (1), 8606042 (1) (see all 30)
5-hydroxyindoleacetic acid	48	47	15161793 (6), 7547218 (6), 18209781 (4), 10463986 (3) (see all 16)
paraffin	47.8	14	1654075 (1), 17614779 (1), 8162254 (1), 10792483 (1) (see all 13)

Search CenterWatch for drugs/clinical trials and news about CHGA / CMGA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHGA gene:

NM_001275.3

Unigene Cluster for CHGA:

Chromogranin A (parathyroid secretory protein 1)

Hs.150793 [show with all ESTs]

Unigene Representative Sequence: NM_001275

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000216492(uc001ybc.4 uc001ybd.4) ENST00000556076 ENST00000553552

ENST00000334654 ENST00000553866 ENST00000556098 ENST00000556876

miRNA Products:		OriGene 3'-UTR Clone: CHGA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHGA
		8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate CHGA (see all 16):
		hsa-miR-124* hsa-miR-320a hsa-miR-137 hsa-miR-25 hsa-miR-92b hsa-miR-22 hsa-miR-577 hsa-miR-92a

		SwitchGear 3'UTR luciferase reporter plasmid: CHGA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHGA (see all 7) OriGene shRNA RFP: CHGA OriGene siRNA: CHGA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHGA

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHGA (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHGA OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHGA (NM_001275)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHGA

Additional cDNA sequence:

AK223381.1 AK313757.1 BC001059.2 BC006459.1 BC009384.2 BC012755.2 BC106953.1 BT006869.1

BX248263.1 J03483.1

15 DOTS entries:

DT.448614 DT.92452247 DT.100649357 DT.75161899 DT.100799484 DT.100873807 DT.120743784 DT.40123857

DT.100873808 DT.100873811 DT.120743772 DT.319042 DT.40123858 DT.91712465 DT.95279114

24/366 AceView cDNA sequences (see all 366):

BQ072205 BX464893 BE382706 CR623573 AA318960 AA976699 BX461228 CR599984

CR593864 Z39925 BE313497 AA319036 CD106587 BP341931 NM_001275 CR596293

CR599908 BX248263 CD107047 CR598626 BU580000 BQ070970 BM972304 BQ720211

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CHGA About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9
SP1:									-
SP2:									-										-		-
SP3:							-		-
SP4:
SP5:

ECgene alternative splicing isoforms for CHGA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHGA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCTCTCCT

About this image

CHGA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

ES04(HES-4) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Endocrine progenitors (Generation of pancre...)

Posterior foregut (Generation of pancre...)

Midbrain dopaminergic-like neurons (Generation of midbra...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CHGA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHGA

SOURCE GeneReport for Unigene cluster: Hs.150793

SABiosciences Expression via Pathway-Focused PCR Arrays including CHGA:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Angiogenic Growth Factors in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHGA Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHGA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CHGA gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CHGA¹	chromogranin A (parathyroid secretory protein 1)	59.05(n) 48.95(a)		423420 XM_421330.3 XP_421330.1
lizard (Anolis carolinensis)	Reptilia	CHGA⁶	--	39(a)	1 ↔ 1	1(11128182-11140200)
African clawed frog (Xenopus laevis)	Amphibia	Xl.1562²	Xenopus laevis transcribed sequence with weak similarity more	80.51(n)		BG346667.1
zebrafish (Danio rerio)	Actinopterygii	chga¹	chromogranin A	51.78(n) 39.61(a)		450039 NM_001006059.1 NP_001006059.1

ENSEMBL Gene Tree for CHGA (if available)
TreeFam Gene Tree for CHGA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CHGA gene

CHGB²

CHGA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150244309^1,2	C,	other	93397681(+)	`CAGACA/GGAGCC`	2	R G	mis¹		0	--	--	--	--
rs7147335^1,2	C,F,A,	--	93387482(+)	`CAAGAT/CACTGA`	1	--	us2k¹		11		NA WA CSA EA	372
rs11364640^1,2	C,	--	93387494(+)	`AGTGA-/TTTTTT`	1	--	us2k¹		2		NA CSA	4
rs6575303^1,2	C,F,H,	--	93387559(+)	`GGGCAC/TAATTC`	1	--	us2k¹		13		NA WA CSA EA	380
rs149523935^1,2		--	93387625(+)	`GAACTC/TTTTCA`	1	--	us2k¹		0	--	--	--	--
rs111830795^1,2	C,	--	93387652(+)	`ACCCAC/TGAAAC`	1	--	us2k¹		2		WA CSA	3
rs10659130^1,2	C,	--	93387662(+)	`actaaCTCT/- ctgtt`	1	--	us2k¹ tfbs³		1		CSA	2
rs151329861^1,2	C	--	93387664(+)	`TAACT-/CTCT GTTTC`	1	--	us2k¹		0	--	--	--	--
rs199896813^1,2	C	--	93387667(-)	`GAGGAA/GACAGT`	1	--	us2k¹		0	--	--	--	--
rs186729550^1,2		--	93387691(+)	`CCTGGA/CAACCA`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CHGA (93389425 - 93401638 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHGA: --
Human Gene Mutation Database (HGMD): CHGA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHGA

DNA2.0 Custom Variant and Variant Library Synthesis for CHGA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CHGA for disorders           About GeneDecksing

OMIM gene information: 118910    OMIM disorders: --

20/192 diseases for CHGA (see all 192):    About MalaCards

zollinger-ellison syndrome malignant peripheral nerve sheath tumor pure red-cell aplasia epithelioid malignant peripheral nerve sheath tumor

von hippel-lindau disease primary pigmented nodular adrenocortical disease multiple endocrine neoplasia islet cell tumor

primitive neuroectodermal tumor dysembryoplastic neuroepithelial tumor non-small cell lung carcinoma sclerosing hemangioma

neuroendocrine tumor temporal lobe epilepsy orthostatic hypotension central neurocytoma

parathyroid adenoma pulmonary sclerosing hemangioma pineocytoma somatostatinoma

12 diseases from the University of Copenhagen DISEASES database for CHGA:

Neuroendocrine tumor Carcinoma Prostate cancer Adenoma

Lung cancer Merkel cell carcinoma Gastritis Pancreatic cancer

Thyroid cancer Phaeochromocytoma Wermer syndrome Diarrhea

10/98 Novoseek disease relationships for CHGA gene (see all 98) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
carcinoid	91.4	245	15757862 (7), 16432362 (7), 1856109 (6), 18535873 (6) (see all 99)
neuroendocrine tumors	90.3	173	9253344 (4), 10569138 (3), 19845257 (3), 1413839 (3) (see all 92)
carcinoma neuroendocrine	89.3	23	8837344 (2), 14533935 (1), 11353063 (1), 18726606 (1) (see all 18)
small cell lung cancer	79.3	41	10460660 (3), 16159442 (2), 11288956 (2), 1315401 (2) (see all 29)
paraganglioma	76.4	15	7599788 (2), 8058707 (1), 17614779 (1), 2188235 (1) (see all 12)
tumors	76.4	792	15053236 (6), 12872342 (6), 17599769 (6), 16188147 (5) (see all 99)
pheochromocytoma	76	172	15850005 (10), 1988765 (7), 16918946 (7), 11116123 (6) (see all 52)
thyroid carcinoma medullary	73.7	29	9664908 (3), 18629788 (2), 11259096 (2), 1356053 (2) (see all 16)
prostatic adenocarcinoma	72.9	20	17285592 (3), 17914093 (2), 18204237 (2), 14990610 (2) (see all 11)
gastrinoma	72.6	22	8323758 (4), 11204811 (3), 12872342 (2), 12144588 (1) (see all 13)

Human Genome Epidemiology (HuGE) Navigator: CHGA (9 documents)

Export disorders for CHGA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CHGA gene, integrated from 9 sources (see all 1476):
(articles sorted by number of sources associating them with CHGA)

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Molecular cloning and primary structure of human chromogranin A (secretory protein I) cDNA. (PubMed id 3403545)^{1, 2, 3} Helman L.J.... Israel M.A. (1988)
Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. (PubMed id 14740315)^{1, 2, 9} Wen G.... Hamilton B.A. (2004)
Conformational preferences and activities of peptides from the catecholamine release-inhibitory (catestatin) region of chromogranin A. (PubMed id 14759560)^{1, 2, 9} Preece N.E.... O'Connor D.T. (2004)
Isolation and characterization of a tumor-derived human protein related to chromogranin A and its in vitro conversion to human pancreastatin-48. (PubMed id 2165909)^{1, 2, 9} Tamamura H.... Funakoshi S. (1990)
Identification and characterization of phosphorylated proteins in the human pituitary. (PubMed id 14997482)^{1, 2, 9} Giorgianni F.... Desiderio D.M. (2004)
The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy. (PubMed id 12442257)^{1, 2, 9} Orr D.F.... Shaw C. (2002)
Phosphorylation and O-glycosylation sites of human chromogranin A (CGA79-439) from urine of patients with carcinoid tumors. (PubMed id 9852066)^{1, 2, 9} Gadroy P.... Metz-Boutigue M.-H. (1998)
Phosphoproteomic analysis of the human pituitary. (PubMed id 16807684)^{1, 2} Beranova-Giorgianni S.... Giorgianni F. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Human chromogranin A gene. Molecular cloning, structural analysis, and neuroendocrine cell-specific expression. (PubMed id 8120054)^{1, 2} Mouland A.J.... Hendy G.N. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1113	HGNC: 1929	AceView: CHGA	Ensembl:ENSG00000100604	euGenes: HUgn1113
ECgene: CHGA	H-InvDB: CHGA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CHGA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CHGA	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CHGA gene
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Patent Information for CHGA gene:
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CHGA Gene

chromogranin A (parathyroid secretory protein 1)

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stable disease
LUNG TUMOR
Neurocytoma Central
Serotonin syndrome
nonmetastatic
Pituitary Tumors
GASTRIC TUMOR
Gastrinoma
Pineal Tumors
Somatostatinoma
Multiple tumors
PARATHYROID ADENOMA
LUNG CARCINOMA
Metaplasia
primary tumor
NSCLC
Nesidioblastosis
Stress Psychological
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THYROID CARCINOMA MEDULLARY
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ERYTHEMA MIGRATORY NECROLYTIC
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ADENOCARCINOMA GASTRIC
Carcinoma Non-Small Cell Lung
GASTRIC CARCINOMA
Hypercalcemia
endocrine neoplasm
Vipoma
Insulinoma
Multiple Endocrine Neoplasia Type 1
primitive neuroectodermal tumor PNET
prostate cancer
Tumors
Pheochromocytoma
Metastasis
prostatic adenocarcinoma
Carcinoma Ductal
pituitary adenoma nonfunctioning
Islet Cell Tumor
Cushing Syndrome
Senile Plaques
Gastritis Atrophic
Adenoma Adrenocortical
BREAST CARCINOMA
genetic hypertension
parathyroid hyperplasia
Hyperplasia
PITUITARY ADENOMA
Medullary Tumors
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epithelial tumor
METASTATIC CARCINOMA
Adenocarcinoma Tubular
Zollinger-Ellison Syndrome
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Ganglioglioma
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Glucagonoma
Paraganglioma
Cancer Lung
Carcinoma Signet Ring Cell
small cell lung cancer
aggressive behavior
Carcinoma Adrenocortical
Pineocytoma
Neuroendocrine Tumors
Carcinoma Large Cell
Carcinoma Undifferentiated
Carcinoma Mucinous
Pancreatic tumor
benign prostatic hyperplasia
Adenoma
Ganglioneuroma
Carcinoma Medullary
Picks Disease
Ewings sarcoma
Carcinoma Squamous Cell
Gastritis
HYPERPARATHYROIDISM PRIMARY
ADRENAL TUMOR
androgen suppression
neuroblastoma metastatic
liver metastases
Carcinoma Neuroendocrine
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Carcinoma Adenosquamous
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CHGA Gene

chromogranin A (parathyroid secretory protein 1)

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