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Aliases for CHGA Gene

Aliases for CHGA Gene

  • Chromogranin A 2 3 5
  • Parathyroid Secretory Protein 1 2 3
  • Pituitary Secretory Protein I 3 4
  • SP-I 3 4
  • CGA 3 4
  • Betagranin (N-Terminal Fragment Of Chromogranin A) 3
  • Chromogranin-A 3
  • Pancreastatin 2
  • Chromofungin 3
  • Vasostatin 2
  • Parastatin 2
  • Catestatin 3

External Ids for CHGA Gene

Previous GeneCards Identifiers for CHGA Gene

  • GC14P090896
  • GC14P087206
  • GC14P091379
  • GC14P092459
  • GC14P093389
  • GC14P073571

Summaries for CHGA Gene

Entrez Gene Summary for CHGA Gene

  • The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CHGA Gene

CHGA (Chromogranin A) is a Protein Coding gene. Diseases associated with CHGA include Neuroendocrine Tumor and Atrophic Gastritis. Among its related pathways are Defensins and Innate Immune System.

UniProtKB/Swiss-Prot for CHGA Gene

  • Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.

  • Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).

  • Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.

Gene Wiki entry for CHGA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHGA Gene

Genomics for CHGA Gene

Regulatory Elements for CHGA Gene

Enhancers for CHGA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G093038 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 +125.8 125849 19.8 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YY1 CBX5 ZNF143 FOS CHGA ITPK1 ITPK1-AS1 GC14P093068 PIR52280
GH14G092846 1.5 FANTOM5 Ensembl ENCODE 11.5 -75.5 -75489 1.4 HDAC1 ATF1 ZSCAN4 TCF12 GATA2 EGR1 FOS RELB IKZF2 CREM TMEM251 CHGA UNC79 RIN3 MOAP1 BTBD7 GON7 PIR36925 GC14P092880 GC14P092879
GH14G093030 1.5 Ensembl ENCODE dbSUPER 10.6 +112.1 112115 7.5 HDGF FOXA2 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 TCF12 ZNF121 ITPK1-AS1 CHGA ITPK1 GC14P093068 PIR52280
GH14G093018 1.3 Ensembl ENCODE dbSUPER 11 +96.8 96813 2.5 SOX13 TBP DRAP1 TFAP4 SAP130 ZMYM3 EBF1 ZNF644 ZNF48 RAD21 CHGA ITPK1 GC14P093068 ITPK1-AS1 PIR52280
GH14G093132 1.3 Ensembl ENCODE dbSUPER 10.7 +210.9 210947 2.0 TBP ARID4B RAD21 RARA YY1 RCOR1 CEBPB NR2F2 ZNF579 STAT3 MOAP1 TMEM251 CHGA ITPK1 CYB5AP3 GC14P093119
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHGA on UCSC Golden Path with GeneCards custom track

Genomic Location for CHGA Gene

Chromosome:
14
Start:
92,922,589 bp from pter
End:
92,935,293 bp from pter
Size:
12,705 bases
Orientation:
Plus strand

Genomic View for CHGA Gene

Genes around CHGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHGA Gene

Proteins for CHGA Gene

  • Protein details for CHGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10645-CMGA_HUMAN
    Recommended name:
    Chromogranin-A
    Protein Accession:
    P10645
    Secondary Accessions:
    • B2R9E9
    • Q53FA8
    • Q6NR84
    • Q96E84
    • Q96GL7
    • Q9BQB5

    Protein attributes for CHGA Gene

    Size:
    457 amino acids
    Molecular mass:
    50688 Da
    Quaternary structure:
    • Interacts with SCG3.
    Miscellaneous:
    • Binds calcium with a low-affinity.

    Three dimensional structures from OCA and Proteopedia for CHGA Gene

neXtProt entry for CHGA Gene

Post-translational modifications for CHGA Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity (PubMed:10781584). Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides (PubMed:17991725).
  • Sulfated on tyrosine residues and/or contains sulfated glycans.
  • Glycosylation at posLast=110110, posLast=181181, Thr183, and posLast=251251
  • Modification sites at PhosphoSitePlus

Other Protein References for CHGA Gene

Antibody Products

  • R&D Systems Antibodies for CHGA (Chromogranin A)

Assay Products

  • Cloud-Clone Corp Assay Kits for CHGA

No data available for DME Specific Peptides for CHGA Gene

Domains & Families for CHGA Gene

Gene Families for CHGA Gene

Protein Domains for CHGA Gene

Suggested Antigen Peptide Sequences for CHGA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10645

UniProtKB/Swiss-Prot:

CMGA_HUMAN :
  • Belongs to the chromogranin/secretogranin protein family.
Family:
  • Belongs to the chromogranin/secretogranin protein family.
genes like me logo Genes that share domains with CHGA: view

Function for CHGA Gene

Molecular function for CHGA Gene

GENATLAS Biochemistry:
chromogranin A (peptide hormones and neurotransmitters secretory protein I;precursor of pancreastatin and vasostatin),overexpressed in sporadic endocrine tumors inflammatory,bowel disease,non endocrine pancreatic disease
UniProtKB/Swiss-Prot Function:
Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas.
UniProtKB/Swiss-Prot Function:
Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).
UniProtKB/Swiss-Prot Function:
Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
genes like me logo Genes that share phenotypes with CHGA: view

Animal Models for CHGA Gene

MGI Knock Outs for CHGA:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHGA

miRNA for CHGA Gene

miRTarBase miRNAs that target CHGA

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHGA Gene

Localization for CHGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHGA Gene

Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. {ECO:0000250}.
Serpinin: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250 UniProtKB:P26339}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHGA gene
Compartment Confidence
extracellular 5
cytoskeleton 3
nucleus 3
cytosol 3
lysosome 3
plasma membrane 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CHGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space ISS --
GO:0016020 membrane IEA --
GO:0030133 transport vesicle IEA --
GO:0030141 secretory granule IEA,ISS --
genes like me logo Genes that share ontologies with CHGA: view

Pathways & Interactions for CHGA Gene

genes like me logo Genes that share pathways with CHGA: view

Pathways by source for CHGA Gene

3 Reactome pathways for CHGA Gene

Gene Ontology (GO) - Biological Process for CHGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002026 regulation of the force of heart contraction ISS --
GO:0002551 mast cell chemotaxis IDA 21214543
GO:0006996 organelle organization ISS --
GO:0008217 regulation of blood pressure TAS 8406464
GO:0019730 antimicrobial humoral response TAS --
genes like me logo Genes that share ontologies with CHGA: view

No data available for SIGNOR curated interactions for CHGA Gene

Drugs & Compounds for CHGA Gene

(63) Drugs for CHGA Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(59) Additional Compounds for CHGA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHGA: view

Transcripts for CHGA Gene

Unigene Clusters for CHGA Gene

Chromogranin A (parathyroid secretory protein 1):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHGA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for CHGA Gene

GeneLoc Exon Structure for
CHGA
ECgene alternative splicing isoforms for
CHGA

Expression for CHGA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHGA Gene

mRNA differential expression in normal tissues according to GTEx for CHGA Gene

This gene is overexpressed in Pituitary (x10.6), Brain - Frontal Cortex (BA9) (x6.5), Stomach (x5.6), Adrenal Gland (x5.4), and Brain - Cortex (x5.1).

Protein differential expression in normal tissues from HIPED for CHGA Gene

This gene is overexpressed in Cerebrospinal fluid (37.4) and Islet of Langerhans (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHGA Gene



Protein tissue co-expression partners for CHGA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHGA Gene:

CHGA

SOURCE GeneReport for Unigene cluster for CHGA Gene:

Hs.150793

mRNA Expression by UniProt/SwissProt for CHGA Gene:

P10645-CMGA_HUMAN
Tissue specificity: GE-25 is found in the brain.

Evidence on tissue expression from TISSUES for CHGA Gene

  • Pancreas(4.9)
  • Nervous system(4.9)
  • Adrenal gland(4.8)
  • Stomach(4.7)
  • Liver(4.5)
  • Thyroid gland(3.6)
  • Intestine(3.2)
  • Lung(2.6)
  • Blood(2.3)
  • Gall bladder(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with CHGA: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CHGA Gene

Orthologs for CHGA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHGA 34 35
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia CHGA 34 35
  • 84.45 (n)
dog
(Canis familiaris)
Mammalia CHGA 34 35
  • 83.25 (n)
mouse
(Mus musculus)
Mammalia Chga 34 16 35
  • 76.02 (n)
rat
(Rattus norvegicus)
Mammalia Chga 34
  • 72.89 (n)
oppossum
(Monodelphis domestica)
Mammalia CHGA 35
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHGA 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHGA 35
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHGA 35
  • 40 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1562 34
zebrafish
(Danio rerio)
Actinopterygii chga 35
  • 31 (a)
OneToOne
Species where no ortholog for CHGA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHGA Gene

ENSEMBL:
Gene Tree for CHGA (if available)
TreeFam:
Gene Tree for CHGA (if available)

Paralogs for CHGA Gene

No data available for Paralogs for CHGA Gene

Variants for CHGA Gene

Sequence variations from dbSNP and Humsavar for CHGA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000019911 -- 92,932,744(+) GCTGG(A/G)GGCCA reference, missense
rs1000032868 -- 92,927,693(+) GATTC(A/G)GCAAG intron-variant
rs1000051650 -- 92,933,303(+) ACACC(G/T)GATGT intron-variant
rs1000144031 -- 92,921,404(+) GTTTG(A/C)GACAG upstream-variant-2KB
rs1000428786 -- 92,927,301(+) TCAGG(C/G)GTTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHGA Gene

Variant ID Type Subtype PubMed ID
esv2749027 CNV deletion 23290073
esv3892576 CNV loss 25118596
nsv1151960 CNV deletion 26484159
nsv1400 CNV deletion 18451855
nsv85624 CNV deletion 16902084

Variation tolerance for CHGA Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.93; 87.21% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHGA Gene

Human Gene Mutation Database (HGMD)
CHGA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHGA Gene

Disorders for CHGA Gene

MalaCards: The human disease database

(154) MalaCards diseases for CHGA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuroendocrine tumor
  • neuroendocrine neoplasm
atrophic gastritis
  • gastric atrophy
acinar cell carcinoma
  • acinic cell carcinoma
tubular adenocarcinoma
  • tubular carcinoma
mixed ductal-endocrine carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search CHGA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHGA

Genetic Association Database (GAD)
CHGA
Human Genome Epidemiology (HuGE) Navigator
CHGA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHGA
genes like me logo Genes that share disorders with CHGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHGA Gene

Publications for CHGA Gene

  1. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. (PMID: 17438154) Rao F. … O'Connor D.T. (Circulation 2007) 3 4 22 46 64
  2. Chromogranin A polymorphisms are associated with hypertensive renal disease. (PMID: 18235090) Salem R.M. … O'Connor D.T. (J. Am. Soc. Nephrol. 2008) 3 22 46 64
  3. Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. (PMID: 19017515) Chen Y. … O'Connor D.T. (J. Am. Coll. Cardiol. 2008) 3 22 46 64
  4. Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. (PMID: 17438153) Lillie E.O. … O'Connor D.T. (Circulation 2007) 3 22 46 64
  5. New antimicrobial activity for the catecholamine release-inhibitory peptide from chromogranin A. (PMID: 15723172) Briolat J. … Metz-Boutigue M.H. (Cell. Mol. Life Sci. 2005) 3 4 22 64

Products for CHGA Gene

Sources for CHGA Gene

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