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Aliases for CHGA Gene

Aliases for CHGA Gene

  • Chromogranin A 2 3
  • Parathyroid Secretory Protein 1 2 3
  • Pituitary Secretory Protein I 3 4
  • SP-I 3 4
  • CGA 3 4
  • Betagranin (N-Terminal Fragment Of Chromogranin A) 3
  • Chromogranin-A 3
  • Pancreastatin 2
  • Chromofungin 3
  • Vasostatin 2
  • Parastatin 2
  • Catestatin 3

External Ids for CHGA Gene

Summaries for CHGA Gene

Entrez Gene Summary for CHGA Gene

  • The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CHGA Gene

CHGA (Chromogranin A) is a Protein Coding gene. Diseases associated with CHGA include atrophic gastritis and lymphocytic colitis. Among its related pathways are Signaling by GPCR and Signaling by GPCR.

UniProtKB/Swiss-Prot for CHGA Gene

  • Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas

  • Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).

  • Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.

Gene Wiki entry for CHGA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHGA Gene

Genomics for CHGA Gene

Genomic Location for CHGA Gene

Start:
92,923,080 bp from pter
End:
92,935,293 bp from pter
Size:
12,214 bases
Orientation:
Plus strand

Genomic View for CHGA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHGA Gene

Regulatory Elements for CHGA Gene

Proteins for CHGA Gene

  • Protein details for CHGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10645-CMGA_HUMAN
    Recommended name:
    Chromogranin-A
    Protein Accession:
    P10645
    Secondary Accessions:
    • B2R9E9
    • Q53FA8
    • Q6NR84
    • Q96E84
    • Q96GL7
    • Q9BQB5

    Protein attributes for CHGA Gene

    Size:
    457 amino acids
    Molecular mass:
    50688 Da
    Quaternary structure:
    • Interacts with SCG3.
    Miscellaneous:
    • Binds calcium with a low-affinity

    Three dimensional structures from OCA and Proteopedia for CHGA Gene

neXtProt entry for CHGA Gene

Proteomics data for CHGA Gene at MOPED

Post-translational modifications for CHGA Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Proteolytic processing gives rise to an additional longer form of catestatin (residues 358-390) which displays a less potent catecholamine release-inhibitory activity (PubMed:10781584). Plasmin-mediated proteolytic processing can give rise to additional shorter and longer forms of catestatin peptides (PubMed:17991725).
  • Sulfated on tyrosine residues and/or contains sulfated glycans
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn110, Thr181, Thr183, and Thr251

Other Protein References for CHGA Gene

No data available for DME Specific Peptides for CHGA Gene

Domains for CHGA Gene

Protein Domains for CHGA Gene

Suggested Antigen Peptide Sequences for CHGA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10645

UniProtKB/Swiss-Prot:

CMGA_HUMAN
Family:
  • Belongs to the chromogranin/secretogranin protein family.:
    • P10645
genes like me logo Genes that share domains with CHGA: view

No data available for Gene Families for CHGA Gene

Function for CHGA Gene

Molecular function for CHGA Gene

GENATLAS Biochemistry: chromogranin A (peptide hormones and neurotransmitters secretory protein I;precursor of pancreastatin and vasostatin),overexpressed in sporadic endocrine tumors inflammatory,bowel disease,non endocrine pancreatic disease
UniProtKB/Swiss-Prot Function: Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas
UniProtKB/Swiss-Prot Function: Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522).
UniProtKB/Swiss-Prot Function: Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.

Gene Ontology (GO) - Molecular Function for CHGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CHGA: view
genes like me logo Genes that share phenotypes with CHGA: view

Animal Models for CHGA Gene

MGI Knock Outs for CHGA:

miRNA for CHGA Gene

miRTarBase miRNAs that target CHGA

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CHGA Gene

Localization for CHGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHGA Gene

Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle membrane. Secreted. Note=Associated with the secretory granule membrane through direct interaction to SCG3 that in turn binds to cholesterol-enriched lipid rafts in intragranular conditions. {ECO:0000250}.
Serpinin: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Pyroglutaminated serpinin localizes to secretory vesicle. {ECO:0000250 UniProtKB:P26339}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHGA Gene COMPARTMENTS Subcellular localization image for CHGA gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 2
nucleus 2
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CHGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0016020 membrane --
GO:0030141 secretory granule IEA --
GO:0030658 transport vesicle membrane IEA --
GO:0042629 mast cell granule IDA 21214543
genes like me logo Genes that share ontologies with CHGA: view

Pathways for CHGA Gene

genes like me logo Genes that share pathways with CHGA: view

Gene Ontology (GO) - Biological Process for CHGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002551 mast cell chemotaxis IDA 21214543
GO:0008217 regulation of blood pressure TAS 8406464
GO:0031640 killing of cells of other organism IEA --
GO:0032762 mast cell cytokine production IDA 21214543
GO:0033604 negative regulation of catecholamine secretion IDA 15326220
genes like me logo Genes that share ontologies with CHGA: view

Compounds for CHGA Gene

(1) HMDB Compounds for CHGA Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(122) Novoseek inferred chemical compound relationships for CHGA Gene

Compound -log(P) Hits PubMed IDs
secretoneurin 83.1 37
zm 336372 73.5 2
111in-pentetreotide 72.7 9
octreotide 68.1 29
catecholamine 64.9 61
genes like me logo Genes that share compounds with CHGA: view

Transcripts for CHGA Gene

Unigene Clusters for CHGA Gene

Chromogranin A (parathyroid secretory protein 1):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHGA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5:

Relevant External Links for CHGA Gene

GeneLoc Exon Structure for
CHGA
ECgene alternative splicing isoforms for
CHGA

Expression for CHGA Gene

mRNA expression in normal human tissues for CHGA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHGA Gene

This gene is overexpressed in Pituitary (10.6), Brain - Frontal Cortex (BA9) (6.5), Stomach (5.6), Adrenal Gland (5.4), and Brain - Cortex (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CHGA Gene

SOURCE GeneReport for Unigene cluster for CHGA Gene Hs.150793

mRNA Expression by UniProt/SwissProt for CHGA Gene

P10645-CMGA_HUMAN
Tissue specificity: GE-25 is found in the brain.
genes like me logo Genes that share expressions with CHGA: view

Orthologs for CHGA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHGA 35
  • 99.64 (n)
  • 100 (a)
CHGA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHGA 35
  • 84.45 (n)
  • 79.24 (a)
CHGA 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHGA 35
  • 83.25 (n)
  • 74.51 (a)
CHGA 36
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chga 35
  • 76.02 (n)
  • 71.46 (a)
Chga 16
Chga 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHGA 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHGA 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chga 35
  • 72.89 (n)
  • 69.25 (a)
chicken
(Gallus gallus)
Aves CHGA 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHGA 36
  • 40 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1562 35
zebrafish
(Danio rerio)
Actinopterygii chga 36
  • 31 (a)
OneToOne
Species with no ortholog for CHGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHGA Gene

ENSEMBL:
Gene Tree for CHGA (if available)
TreeFam:
Gene Tree for CHGA (if available)

Paralogs for CHGA Gene

No data available for Paralogs for CHGA Gene

Variants for CHGA Gene

Sequence variations from dbSNP and Humsavar for CHGA Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7610 -- 92,934,971(-) GCAGC(A/G)TCCGG utr-variant-3-prime
rs729939 -- 92,932,824(+) GAGGA(A/G)GAGGG synonymous-codon, reference
rs729940 - 92,932,756(+) CCTCC(C/T)GGGAG reference, missense
rs735726 -- 92,928,234(-) GAAAA(A/T)CACTC intron-variant
rs750678 -- 92,934,534(-) ATGGT(C/T)CCGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHGA Gene

Variant ID Type Subtype PubMed ID
nsv902200 CNV Loss 21882294
nsv1400 CNV Loss 18451855
nsv902201 CNV Loss 21882294
esv2749027 CNV Deletion 23290073
nsv85624 CNV Loss 16902084
nsv902202 CNV Loss 21882294
nsv902203 CNV Loss 21882294

Relevant External Links for CHGA Gene

HapMap Linkage Disequilibrium report
CHGA
Human Gene Mutation Database (HGMD)
CHGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHGA Gene

Disorders for CHGA Gene

(98) Novoseek inferred disease relationships for CHGA Gene

Disease -log(P) Hits PubMed IDs
carcinoid 91.4 163
neuroendocrine tumors 90.3 123
carcinoma neuroendocrine 89.3 19
small cell lung cancer 79.3 34
paraganglioma 76.4 13

Relevant External Links for CHGA

Genetic Association Database (GAD)
CHGA
Human Genome Epidemiology (HuGE) Navigator
CHGA
genes like me logo Genes that share disorders with CHGA: view

No data available for UniProtKB/Swiss-Prot for CHGA Gene

Publications for CHGA Gene

  1. Catecholamine release-inhibitory peptide catestatin (chromogranin A(352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. (PMID: 17438154) Rao F. … O'Connor D.T. (Circulation 2007) 3 4 23 48
  2. Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology. (PMID: 14740315) Wen G. … Hamilton B.A. (Am. J. Hum. Genet. 2004) 3 4 23
  3. Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function. (PMID: 17438153) Lillie E.O. … O'Connor D.T. (Circulation 2007) 3 23 48
  4. The spectrum of endogenous human chromogranin A-derived peptides identified using a modified proteomic strategy. (PMID: 12442257) Orr D.F. … Shaw C. (Proteomics 2002) 3 4 23
  5. The catecholamine release-inhibitory "catestatin" fragment of chromogranin a: naturally occurring human variants with different potencies for multiple chromaffin cell nicotinic cholinergic responses. (PMID: 15326220) Mahata S.K. … O'Connor D.T. (Mol. Pharmacol. 2004) 3 4 23

Products for CHGA Gene

Sources for CHGA Gene

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