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CHFR Gene

protein-coding GIFtS: 59

GC12M131927

checkpoint with forkhead and ring finger domains
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.3.2.- ^³
FLJ10796 ^¹, ²
FLJ33629 ^²
RNF116 ^²
RNF196 ^¹, ², ³

Descriptions
Checkpoint with forkhead and RING finger domains protein ^³
RING finger protein 196 ^³
checkpoint with forkhead and ring finger domains ^²

External Ids
HGNC: 20455¹
Entrez Gene: 55743²
UniProtKB: Q96EP1³
Ensembl: ENSG00000072609⁷

Search outside databases for aliases for CHFR gene

Previous GC identifers: GC12M130925 GC12M132970 GC12M133041 GC12M131655 GC12M132027

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CHFR_HUMAN, Q96EP1

Function: E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when

they are exposed to microtubule poisons. Acts in early prophase before chromosome condensation,

when the centrosome move apart from each other along the periphery of the nucleus. Probably

promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific

ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated

at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling

cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress

caused by microtubule poisons

Gene Wiki entry for CHFR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CHFR gene

Entrez Gene cytogenetic band: 12q24.33 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.33

CHFR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M131927: (about GC identifiers)

Start:	131,927,011 bp from pter
End:	131,974,257 bp from pter
Size:	47,247 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_024477.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CHFR_HUMAN, Q96EP1 (See protein sequence)

Recommended Name: E3 ubiquitin-protein ligase CHFR

Size: 664 amino acids; 73386 Da

Subcellular location: Nucleus

Developmental stage: Weakly expressed in G1 phase, and highly expressed during S phase

Caution: PubMed:11807090 and PubMed:11912157 report that it can ubiquitinate and promote the

degradation of substrates. PubMed:11807090 reports that, in Xenopus extracts, it ubiquitinates

PLK, a protein kinase involved in mitotic progression. However, as experiments have been done

either in vitro or with extracts from Xenopus, there is actually little evidence for a role for

CHFR in protein degradation in vivo

PDB structure from and Proteopedia :

1LGP (3D)

1LGQ (3D)

Secondary accessions: A6NEN5 Q96SL3 Q9NRT4 Q9NT32 Q9NVD5

Alternative splicing: 3 isoforms: Q96EP1-1 Q96EP1-2 Q96EP1-3

Post-translational modifications:

Autoubiquitinated in vitro¹

Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated by PKB.

Phosphorylation may affect its E3 ligase activity¹

REFSEQ proteins: NP_060693.1

ENSEMBL proteins:

ENSP00000266880 ENSP00000320557

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CHFR)
	Human Recombinant Proteins from Abnova (CHFR)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	10935642
GO:0005634	nucleus	IEA	--

About this table

Antibodies for CHFR:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CHFR
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (CHFR), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CHFR)
	Novus Biologicals Antibodies for CHFR

Assays for CHFR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q96EP1

ProtoNet protein and cluster: Q96EP1

2 Blocks protein families:

IPB000253 Forkhead-associated (FHA)

IPB001841 Zn-finger

UniProtKB/Swiss-Prot: CHFR_HUMAN, Q96EP1

Domain: The FHA domain may be required to interact with phosphorylated proteins

Similarity: Contains 1 FHA domain

Similarity: Contains 1 RING-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHFR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHFR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018223

Applied Biosystems Silencer® siRNAs for CHFR

Sigma-Aldrich siRNA and siRNA Panels for CHFR

Sigma-Aldrich shRNA Panels and shRNA for CHFR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CHFR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018223
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018223
untagged cDNA clone in CMV expression vector: NM_018223

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018223

UniProtKB/Swiss-Prot: CHFR_HUMAN, Q96EP1

Function: E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when

they are exposed to microtubule poisons. Acts in early prophase before chromosome condensation,

when the centrosome move apart from each other along the periphery of the nucleus. Probably

promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific

ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated

at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling

cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress

caused by microtubule poisons

Enzyme Number (IUBMB): EC 6.3.2.-

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Chfr):

cellular

homeostasis/metabolism

life span-post-weaning/aging

tumorigenesis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18504434
GO:0008270	zinc ion binding	IEA	--
GO:0016874	ligase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: CHFR_HUMAN, Q96EP1

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for CHFR

5/49 Interacting proteins for CHFR (ENSP00000266880³ Q96EP1^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TPT1	P13693¹	EBI-718923, EBI-1783169
BRD4	O60885²	MINT-63187
EEF1G	P26641²	MINT-65139
ITGAE	P38570²	MINT-65140
WDR47	O94967²	MINT-65138

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	IEA	--
GO:0007093	mitotic cell cycle checkpoint	TAS	10935642
GO:0019941	modification-dependent protein catabolic process	IEA	--
GO:0051301	cell division	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CHFR

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CHFR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CHFR)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018223

Sigma-Aldrich siRNA and siRNA Panels for CHFR

Sigma-Aldrich shRNA Panels and shRNA for CHFR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018223

REFSEQ mRNAs for CHFR gene:

NM_018223.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018223

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018223
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018223
                                 untagged cDNA clone in CMV expression vector: NM_018223

Additional cDNA sequence:

AF170724.1 AK001658.1 AK027687.1 AK054917.1 AK090948.1 AK097671.1 AK302785.1 AK304333.1

AL137561.1 BC012072.1 CR625905.1

24/29 DOTS entries (see all 29 ):

DT.91745950 DT.95373888 DT.91938691 DT.100785161 DT.121214174 DT.121214046 DT.92030999 DT.95373893

DT.92019957 DT.100027451 DT.100655031 DT.100662721 DT.121214189 DT.91745952 DT.95130462 DT.100785163

DT.100785165 DT.115285 DT.100644971 DT.100696626 DT.121213895 DT.121213963 DT.121214089 DT.40122609

24/141 AceView cDNA sequences (see all 141 ):

AU134937 L06148 AB027133 AI366659 BG677300 BU521351 BG680920 AI370484

BM558904 AL044812 BE764999 CR625905 AA351608 BQ887242 BQ073354 CB117189

AW005470 BG679233 BG740693 AU132825 BQ936072 AJ707343 BU148471 BM541730

highest scoring ESTs for CHFR:

AF170724 AI967983 AK001658 AK027687 AU132825 BI769973 BQ887242 BQ924736 BQ936072 BU148471

Unigene Cluster for CHFR:

Checkpoint with forkhead and ring finger domains

Hs.656770 [show with all ESTs]

Unigene Representative Sequence: BC012072

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CHFR (see all 14 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	·	16c	^
SP1:					-						-						-		-				-				-		-																		-		-
SP2:					-						-						-		-								-		-																		-		-
SP3:					-						-						-		-				-		-				-																		-		-
SP4:											-						-		-				-		-		-		-																		-		-
SP5:																																											-		-		-		-

ExUns:	17a	·	17b	^	18a	·	18b	^	19a	·	19b	^	20	^	21	^	22a	·	22b	·	22c	·	22d	·	22e	·	22f
SP1:	-		-						-
SP2:	-		-						-
SP3:	-		-						-
SP4:	-								-
SP5:	-		-						-

About this scheme

ECgene alternative splicing isoforms for CHFR

2 Ensembl transcripts including schematic representations:

ENST00000266880 ENST00000315585

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CHFR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CHFR

¹ / ² / ³

6 probe-sets matching CHFR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57330_s_at²^{, 3}	U95-C	1	1.00	1.00	0.94	1.11	R55179	0.40	1.00	0.76	1
63859_at²^{, 3}	U95-C	1	1.00	1.00	0.99	0.89	AI967983	0.80	0.88	0.84	1
223931_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF170724	0.80	0.88	0.84	1
218803_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_018223	0.60	0.83	0.73	1
223931_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218803_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CHFR for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCATCTGGAA

SOURCE GeneReport for Unigene cluster: Hs.656770
UniProtKB/Swiss-Prot: CHFR_HUMAN, Q96EP1
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CHFR gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CHFR¹	--	checkpoint with forkhead and ring finger domains	81.8(n) 81.31(a)	477434 XM_843543.1 XP_848636.1
rat (Rattus norvegicus)	Chfr¹	--	checkpoint with forkhead and ring finger domains	80.41(n) 81.32(a)	288734 NM_001009258.1 NP_001009258.1
mouse (Mus musculus)	Chfr^{1, 5}	5⁵	checkpoint with forkhead and ring finger domains^{1, 5}	80.68(n)¹ 80.68(a)¹	231600¹ NM_172717.2¹ NP_766305.1¹ AI850707⁵ AK039281⁵ (see all 21)
chicken (Gallus gallus)	CHFR¹	--	checkpoint with forkhead and ring finger domains	68.82(n) 73.3(a)	416792 XM_415086.2 XP_415086.2
zebrafish (Danio rerio)	si:dkey-69h6.7¹	--	si:dkey-69h6.7	60.1(n) 58.44(a)	564271 NM_001100015.1 NP_001093485.1

About this table Species with no ortholog for CHFR

ENSEMBL Gene Tree for CHFR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/442 NCBI SNPs in CHFR are shown (see all 442 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 88)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2306536^1,2	A,C,F,H	131933735(+)	`AGCCAC/TGAGGC`	1	V/M	mis¹ ese³		11		EA MN EU WA NA	1844
--	rs1045979^1,2	C,F,H,O	131928142(-)	`GACAAG/ACACGT`	1	--	ut3¹ ese³		6		EA MN EU WA	2100
	rs3741490^1,2	A,C,F,H	131927981(+)	`CACCAC/TGAGCC`	1	--	ut3¹ ese³		5		EA EU WA	1902
	rs2306541^1,2	C,F,H	131938315(+)	`GCTCCG/ACTCTC`	1	V/A	mis¹		9		EA EU WA	2318
	rs3741489^1,2	C,F,H	131927875(+)	`ACTTCT/CGCTTT`	1	--	ut3¹ ese³		12		EA EU WA NA	2460
	rs3741494^1,2	C,F,H	131974573(+)	`ACGGTC/TCATCT`	1	--	ng3¹		15		EA MN EU WA	3984
	rs8021^1,2	C,F,H	131927358(-)	`AGCCCA/GGGGCT`	1	--	ut3¹ ese³		3		MN EU	490
	rs4758909^1,2	C,F,H	131927862(+)	`TTCCTG/AAAAAC`	1	--	ut3¹		11		EU EA WA NA	974
	rs15638^1,2	A,C	131927435(+)	`GGCCGC/TGGTCA`	1	--	ut3¹ ese³		0	--	--	--	--
--	rs1046130^1,2	C	131927037(-)	`ATATTC/TTAATA`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for CHFR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605209

UniProtKB/Swiss-Prot: CHFR_HUMAN, Q96EP1

Defects in CHFR may be involved in colon, lung and esophageal cancers and non small cell

lung carcinomas (NSCLC). In addition, CHFR gene is silenced in many primary cancers because of CpG

methylation and deacetylated histones on its promoter region. This however raises the question of

whether CHFR silencing is a consequence or a cause of primary cancers

1 Novoseek disease relationship for CHFR gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	0.00	2	15631682 (1), 10935642 (1)

About this table

Human Gene Mutation Database: CHFR
Human Genome Epidemiology Navigator: CHFR (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/49 PubMed articles for CHFR gene (see all 49 ):

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition. (PubMed id 11807090)^{1, 2, 3, 4} Kang D....Fang G. (2002)
Chfr defines a mitotic stress checkpoint that delays entry into metaphase. (PubMed id 10935642)^{1, 2, 3, 4} Scolnick D.M. and Halazonetis T.D. (2000)
Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity. (PubMed id 11912157)^{1, 3, 4} Chaturvedi P.... Zhou B.-B. (2002)
The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. (PubMed id 14562038)^{1, 3, 4} Bothos J.... Halazonetis T.D. (2003)
Promotion of mitosis by activated protein kinase B after DNA damage involves polo-like kinase 1 and checkpoint protein CHFR. (PubMed id 14638868)^{1, 3, 4} Shtivelman E. (2003)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
CHFR-associated early G2/M checkpoint defects in breast cancer cells. (PubMed id 14694445)^{3, 4} Erson A.E. and Petty E.M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer. (PubMed id 12538348)^{3, 4} Corn P.G.... El-Deiry W.S. (2003)
Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer. (PubMed id 14695171)^{3, 4} Satoh A.... Imai K. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55743	HGNC: 20455	AceView: GOLGA3	Ensembl:ENSG00000072609	euGenes: HUgn55743
ECgene: CHFR	H-InvDB: CHFR

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CHFR	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CHFR
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CHFR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CHFR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CHFR		Antibodies for CHFR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CHFR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CHFR)
	Antibodies (CHFR)
	Chimera RNAi (CHFR)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CHFR)
	Antibodies (CHFR)

Search OriGene for CHFR

Search Tocris compounds for CHFR

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Antibodies for CHFR

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CHFR Gene at Home site.
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CHFR Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for CHFR

Summaries
for CHFR

Genomic Location
for CHFR

Proteins
for CHFR

Protein Domains/
Families
for CHFR

Gene Function
for CHFR

Pathways & Interactions
for CHFR

Drugs & Compounds
for CHFR

Transcripts
for CHFR

Expression
for CHFR

Orthologs
for CHFR

Paralogs
for CHFR

SNPs/Variants
for CHFR

Disorders & Mutations
for CHFR

Medical News
for CHFR

Publications
for CHFR

Search for CHFR

Genome Databases showing CHFR

Other Databases showing CHFR

Specialized Databases showing CHFR

Licensable Technologies
for CHFR

Services
for CHFR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CHFR Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor CHFR

Summariesfor CHFR

Genomic Locationfor CHFR

Proteinsfor CHFR

Protein Domains/Familiesfor CHFR

Gene Functionfor CHFR

Pathways & Interactionsfor CHFR

Drugs & Compoundsfor CHFR

Transcriptsfor CHFR

Expression for CHFR

Orthologsfor CHFR

Paralogsfor CHFR

SNPs/Variantsfor CHFR

Disorders & Mutationsfor CHFR

Medical Newsfor CHFR

Publicationsfor CHFR

Search for CHFR

Genome Databases showing CHFR

Other Databases showing CHFR

Specialized Databases showing CHFR

Licensable Technologiesfor CHFR

Servicesfor CHFR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CHFR

Summaries
for CHFR

Genomic Location
for CHFR

Proteins
for CHFR

Protein Domains/
Families
for CHFR

Gene Function
for CHFR

Pathways & Interactions
for CHFR

Drugs & Compounds
for CHFR

Transcripts
for CHFR

Expression
for CHFR

Orthologs
for CHFR

Paralogs
for CHFR

SNPs/Variants
for CHFR

Disorders & Mutations
for CHFR

Medical News
for CHFR

Publications
for CHFR

Licensable Technologies
for CHFR

Services
for CHFR