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Aliases & Descriptions for FOXN3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases C14orf116 2 , 3 CHES1 2 , 3 , 5 PRO1635 2
Descriptions Checkpoint suppressor 1 1 , 2 , 3 chromosome 14 open reading frame 116 1 forkhead box N3 2
Search outside databases for aliases for FOXN3 gene
Summaries for FOXN3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
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EntrezGene summary for FOXN3 : This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints areeukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activatinga MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting indistinct isoforms. [provided by RefSeq] UniProtKB/Swiss-Prot: FOXN3_HUMAN, O00409 Function : Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cyclearrests (checkpoints)
Gene Wiki entry for FOXN3
Genomic Location for FOXN3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q31.3 Ensembl cytogenetic band: 14q32.11 HGNC cytogenetic band: 14q24.3-q31 FOXN3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14M088692:
(about GC identifiers )
Start:
88,692,269 bp from pter
End:
89,155,247 bp from pter
Size:
462,979 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000014.7 NT_026437.11 Proteins for FOXN3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: FOXN3_HUMAN, O00409 (See
protein sequence )Recommended Name: Forkhead box protein N3 Size : 490 amino acids; 53835 Da
Subunit : Interacts through its C-terminus with the C-terminus of SNW1/SKIP
Subcellular location : Nucleus (Probable)
Secondary accessions : Q96II7 Q9UIE7Alternative splicing : 2 isoforms : O00409-1 O00409-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001078940.1 NP_005188.2 ENSEMBL proteins: ENSP00000343288 ENSP00000261302 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: FOXN3 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for FOXN3: Assays for FOXN3:
Protein
Domains/ Families for FOXN3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O00409 ProtoNet protein and cluster: O00409
UniProtKB/Swiss-Prot: FOXN3_HUMAN, O00409 Similarity : Contains 1 fork-head DNA-binding domain
Gene Function for FOXN3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005197 Applied Biosystems Silencer ® siRNAs for FOXN3 Sigma-Aldrich siRNA for FOXN3 Sigma-Aldrich shRNA for FOXN3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001085471                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001085471                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001085471  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001085471 UniProtKB/Swiss-Prot: FOXN3_HUMAN, O00409 Function : Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cyclearrests (checkpoints)
4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for FOXN3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Interacting protein for FOXN3 (O00409 1 ) via UniProtKB, MINT, and/or STRING About this table 5 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for FOXN3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
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Transcripts for FOXN3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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RNAi Products from Invitrogen ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005197 Sigma-Aldrich siRNA for FOXN3 Sigma-Aldrich shRNA for FOXN3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001085471 NM_005197
REFSEQ mRNAs for FOXN3 gene (2 alternative transcripts): NM_001085471.1 NM_005197.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001085471 NM_005197
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001085471                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001085471                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001085471  
Additional cDNA sequence: AK055175.1 AK123929.1 AK225967.1 AK308053.1 AK314098.1 BC007506.2 BC010227.1 BC010460.1 U68723.1
23 DOTS entries : DT.95364202 DT.100780283 DT.99975505 DT.101960788 DT.120784181 DT.120784076 DT.92430326 DT.121089966 DT.40121707 DT.91702420 DT.120784334 DT.91702406 DT.100795350 DT.118147 DT.120784245 DT.92430313 DT.120783936 DT.121290117 DT.91702408 DT.95076327 DT.100780286 DT.120783971 DT.120784219
24/276 AceView cDNA sequences (see all 276
):AI652220 AW241326 AI684446 BQ186358 AI084011 BE855907 BU172864 AI078525 NM_005197 AW072318 F10648 AA280130 BQ027624 AL704050 BX117138 AI056946 BM916964 BQ186502 BX283610 H23740 AA947170 AA481039 BX117076 AI917297
Unigene Cluster for FOXN3: Forkhead box N3 Hs.434286 [show with all ESTs ] Unigene Representative Sequence: NM_005197 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for FOXN3 ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 SP1 :     -       -     -   -       SP2 :     -       -     -         SP3 :                       SP4 :           -            
About this scheme ECgene alternative splicing isoforms for FOXN3 2 Ensembl transcripts including schematic representations : ENST00000345097
ENST00000261302
Expression for FOXN3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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FOXN3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for FOXN3 1 / 2
15 probe-sets matching FOXN3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAACTCCAGASOURCE GeneReport for Unigene cluster: Hs.434286
Orthologs for FOXN3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for FOXN3 gene from 5 species
About this table Species with no ortholog for FOXN3 ENSEMBL Gene Tree for FOXN3 Paralogs for FOXN3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for FOXN3 gene FOXM1 2 FOXN2 2
SNPs/Variants for FOXN3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for FOXN3 (up to first 250kb)
Disorders & Mutations for FOXN3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 602628 2 Novoseek disease relationships for FOXN3 gene
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Medical News for FOXN3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for FOXN3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/19 PubMed articles for FOXN3 gene (see all 19
): Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA. (PubMed id 9154802) 1, 2, 3, 4 Pati D.... Plon S.E. (1997) CHES1/FOXN3 interacts with Ski-interacting protein and acts as a transcriptional repressor. (PubMed id 16102918) 1, 3, 4 Scott K.L. and Plon S.E. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 3, 4 Heilig R.... Weissenbach J. (2003) Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response. (PubMed id 16951149) 1, 3 Busygina V....Bale A.E. (2006) A child with deletion (14)(q24.3q32.13) and auditory neuropathy. (PubMed id 18074379) 3 Schlade-Bartusiak K....Cox D.W. (2008) Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets. (PubMed id 17983802) 3 Katoh H....Shibata T. (2007) A protein interaction framework for human mRNA degradation. (PubMed id 15231747) 3 Lehner B. and Sanderson C.M. (2004) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 3 Suzuki Y.... Sugano S. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004)
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Genome Databases showing FOXN3
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Specialized Databases showing FOXN3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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