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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHERP Gene

protein-coding   GIFtS: 51
GCID: GC19M016629

calcium homeostasis endoplasmic reticulum protein
 Explore 23 diseases affiliated with
CHERP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CHERP    

Aliases
for CHERP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Calcium Homeostasis Endoplasmic Reticulum Protein1 2     SR-Related CTD-Associated Factor 62 3
DAN161 2     SRA12
ERPROT213-211 2     Protein With Polyglutamine Repeat2
SCAF62 3     SR-Related CTD Associated Factor 62
ERPROT 213-212 3     DAN263

External Ids:    HGNC: 169301   Entrez Gene: 105232   Ensembl: ENSG000000858727   UniProtKB: Q8IWX83   

Export aliases for CHERP gene to outside databases

Previous GC identifers: GC19M017122 GC19M017020 GC19M016473 GC19M016489 GC19M016197


Summaries
for CHERP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8
Function: Involved in calcium homeostasis, growth and proliferation




Genomic Views
for CHERP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHERP gene promoter:
         NF-1   LHX3b/Lhx3b   Pax-6   Pax-2   MIF-1   Pax-2a   XBP-1   GATA-2   RORalpha1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHERP promoter sequence
   Search SABiosciences Chromatin IP Primers for CHERP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHERP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1

CHERP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHERP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M016629:  view genomic region     (about GC identifiers)

Start:
 16,628,700 bp from pter      End:
 16,653,341 bp from pter
Size:
 24,642 bases      Orientation:
 minus strand

Proteins
for CHERP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8 (See protein sequence)
Recommended Name: Calcium homeostasis endoplasmic reticulum protein  
Size: 916 amino acids; 103702 Da
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Distributed throughout the
cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells.
Colocalizes with ITPR1
Sequence caution: Sequence=AAB53327.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH21294.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA69591.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA69591.1; Type=Frameshift;
Positions=450;
Secondary accessions: O00302 Q4G0Y5 Q8WU30 Q99492

Explore the universe of human proteins at neXtProt for CHERP: NX_Q8IWX8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IWX8

    • CHERP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006378.3  
    ENSEMBL proteins: 
     ENSP00000439856   ENSP00000198939  

    Human Recombinant Protein Products: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CHERP
    OriGene Custom Protein Services for CHERP 
    GenScript Custom Purified and Recombinant Proteins Services for CHERP
    Novus Biologicals CHERP Proteins
    Novus Biologicals CHERP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CHERP

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10794731
    GO:0033017sarcoplasmic reticulum membrane ISS--
    GO:0048471perinuclear region of cytoplasm IDA12656674


    CHERP for ontologies           About GeneDecksing



    CHERP Antibody Products: 
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    Uscn Antibodies for CHERP
    ThermoFisher Antibodies for CHERP

    Assay Products for CHERP: 
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    Uscn ELISAs and CLIAs for CHERP

    Protein Domains /
    Families
    for CHERP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CHERP for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR006569 RNA_polymerase_II_lsu_CTD
     IPR000061 Surp
     IPR006903 RNA_pol_II-bd
     IPR000467 G_patch_dom
     IPR008942 ENTH_VHS

    Graphical View of Domain Structure for InterPro Entry Q8IWX8

    ProtoNet protein and cluster: Q8IWX8

    3 Blocks protein families:
    IPB000061 SWAP/Surp
    IPB000467 D111/G-patch domain
    IPB006569 Regulation of nuclear pre-mRNA protein


    UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8
    Similarity: Contains 1 CID domain
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 1 SURP motif repeat


    Function
    for CHERP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8
    Function: Involved in calcium homeostasis, growth and proliferation

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHERP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CHERP (see all 9):
    hsa-miR-3671 hsa-miR-607 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548v hsa-miR-16-1* hsa-miR-551b* hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: CHERP 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHERP (see all 7)
    OriGene shRNA RFP: CHERP
    OriGene siRNA: CHERP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHERP

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CHERP

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHERP (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CHERP (NM_006387)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHERP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHERP 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CHERP
    Search LifeMap BioReagents cell lines for CHERP

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHERP

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0044325ion channel binding IPI--


    CHERP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CHERP:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for CHERP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA Splicing - Major Pathway
    		Spliceosome0.31

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    1         Kegg Pathway  (Kegg details for CHERP):
        Spliceosome


    CHERP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHERP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for CHERP (Q8IWX82, 3 ENSP000001989394) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LUC7LQ9NQ292, ENSP000002938724MINT-8334769 MINT-8331481 STRING: ENSP00000293872
    DHX8Q145622, ENSP000002624154MINT-8334648 MINT-8331448 STRING: ENSP00000262415
    U2AF2P263682, ENSP000003078634MINT-8334142 MINT-8331437 STRING: ENSP00000307863
    FRA10AC1Q70Z532, ENSP000003604884MINT-8331459 MINT-8334670 STRING: ENSP00000360488
    SNRNP27Q8WVK22, ENSP000002442274MINT-8331470 MINT-8334725 STRING: ENSP00000244227
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--
    GO:0006874cellular calcium ion homeostasis IDA10794731
    GO:0007399nervous system development TAS8896557
    GO:0008285negative regulation of cell proliferation IDA10794731
    GO:0051209release of sequestered calcium ion into cytosol IMP12656674


    CHERP for ontologies           About GeneDecksing



    Drugs & Compounds
    for CHERP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHERP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHERP

    1 HMDB Compound for CHERP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    3 Novoseek chemical compound relationships for CHERP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 89.4 189 17028181 (5), 12676955 (5), 11751688 (4), 15470501 (4) (see all 95)
    testosterone 12.6 1 11751688 (1)
    calcium 0 7 12656674 (2), 10794731 (1)

    Search CenterWatch for drugs/clinical trials and news about CHERP 

    Transcripts
    for CHERP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CHERP gene: 
    NM_006387.5  

    Unigene Cluster for CHERP:

    Calcium homeostasis endoplasmic reticulum protein
    Hs.740364  [show with all ESTs]
    Unigene Representative Sequence: NM_006387
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546361(uc010xpg.1 uc002nei.1) ENST00000198939 ENST00000544299
    ENST00000546538(uc002nej.3) ENST00000551747

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CHERP
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHERP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CHERP (see all 9):
    hsa-miR-3671 hsa-miR-607 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548v hsa-miR-16-1* hsa-miR-551b* hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: CHERP 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHERP (see all 7)
    OriGene shRNA RFP: CHERP
    OriGene siRNA: CHERP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHERP
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHERP (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHERP (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CHERP (NM_006387)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHERP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHERP 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHERP
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHERP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHERP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHERP

    Additional cDNA sequence: 

    AB209730.1 AF536542.1 AK296883.1 AK298408.1 BC001552.2 BC021294.2 U94836.2 Y08265.1 

    19 DOTS entries:

    DT.97804090  DT.95090896  DT.100781339  DT.318015  DT.97811429  DT.92445379  DT.92004744  DT.91652495 
    DT.99994208  DT.121500561  DT.100706502  DT.40132863  DT.95254795  DT.100883373  DT.101958784  DT.121500661 
    DT.95254782  DT.86837691  DT.97846751 

    24/361 AceView cDNA sequences (see all 361):

    CF593909 AI348577 AI262272 BI908372 BI763944 BQ434588 AI024437 CB241570 
    BM545482 NM_006387 AW978303 CF593296 CB163182 BI029115 BE741277 BX331460 
    BE675623 BQ045157 AA213835 BI820034 BM711737 AW058464 AA887727 BM692273 

    GeneLoc Exon Structure


    Expression
    for CHERP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHERP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCAGCCTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CHERP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHERP

    SOURCE GeneReport for Unigene cluster: Hs.740364

    UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8
    Tissue specificity: Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and in
    cultured HEL and Dami cells

        SABiosciences Custom PCR Arrays for CHERP
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHERP

    Orthologs
    for CHERP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHERP gene from 9/27 species (see all 27)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cherp1 , 5 calcium homeostasis endoplasmic reticulum protein1, 5 85.74(n)1
    95.51(a)1    		   8 (35.08 cM)5
    279671  NM_138585.31  NP_613051.31 
     724604895 
    chicken
    (Gallus gallus)    		 Aves CHERP1 calcium homeostasis endoplasmic reticulum protein 76.79(n)
    89.62(a)    		   420144  XM_001233543.2  XP_001233544.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CHERP6
    		 --
    		 83(a)
    		 1 ↔ 1
    		 AAWZ02036422(12187-21185)
    African clawed frog
    (Xenopus laevis)    		 Amphibia cherp-prov2 calcium homeostasis endoplasmic reticulum protein 76.24(n)    BC046715.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii iktdsubc_2h122 iktdsubc_2h12 77.12(n)   337851  AF536545.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta scaf61 BP1047 49.46(n)
    41.3(a)    		   3346235  NM_001014589.3  NP_001014589.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea tag-651 Protein TAG-65 39.46(n)
    30.47(a)    		   179857  NM_073985.3  NP_506386.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G312006
    		 SWAP/Surp domain-containing protein
    		 19(a)
    		 1 ↔ 1
    		 4(15161636-15164914)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 surp module family protein, putative, expressed
    		 20(a)
    		 1 ↔ 1
    		 6(28451965-28455731)


    ENSEMBL Gene Tree for CHERP (if available)
    TreeFam Gene Tree for CHERP (if available) 

    Paralogs
    for CHERP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHERP gene
    ZRANB22  

    CHERP for paralogs           About GeneDecksing



    Genomic Variants
    for CHERP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/426 NCBI SNPs in CHERP are shown (see all 426)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1885519581,2
    		--16628236(+) GGTGGA/GGGCAG 2 -- int10--------
    rs1421429681,2
    		C,--16628260(+) GATGG-/ACACACA 2 -- int10--------
    rs1449264441,2
    		--16628321(+) GCTGCA/GGTGAG 2 -- int10--------
    rs1490608751,2
    		--16628343(+) CCTCTA/GAGCCA 2 -- int10--------
    rs1927523641,2
    		--16628393(+) GCTCTA/GTGACA 2 -- int10--------
    rs1437738551,2
    		--16628483(+) AGCTCC/TACCCA 2 -- int10--------
    rs754132701,2
    		F,--16628549(+) CTGCTC/TGAGGG 2 -- int12Minor allele frequency- T:0.03WA EA 238
    rs1468531211,2
    		--16628579(+) CAGCAC/TGCTGG 2 -- int10--------
    rs285419521,2
    		C,--16628776(+) GTTTAC/TGTTTT 2 -- ut31 int1 ese31Minor allele frequency- T:0.01WA 118
    rs1843995711,2
    		--16628827(+) ATCTAC/GAACAA 2 -- int1 ut310--------

    HapMap Linkage Disequilibrium report for CHERP (16628700 - 16653341 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CHERP: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHERP
    DNA2.0 Custom Variant and Variant Library Synthesis for CHERP

    Disorders / Diseases
    for CHERP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CHERP for disorders           About GeneDecksing

    20/23 diseases for CHERP (see all 23):    About MalaCards
    spinal-bulbar muscular atrophy    machado-joseph disease    spinocerebellar ataxia type 7    spinocerebellar ataxia
    spinocerebellar ataxia type 8    oculopharyngeal muscular dystrophy    spinocerebellar ataxia type 3    spinocerebellar degeneration
    muscular atrophy    muscular dystrophy    hepatic encephalopathy    ataxia
    neurodegenerative disease    fanconi's anemia    huntington's disease    hereditary ataxia
    parkinson's disease    neurodegeneration    anemia    hepatitis

    10/13 Novoseek disease relationships for CHERP gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spinocerebellar ataxias 84.9 4 15198995 (1), 16791428 (1), 11511401 (1), 16831871 (1)
    spinocerebellar ataxia type 1 83.1 1 10624951 (1)
    huntington disease 81.6 7 15198995 (1), 19240033 (1), 16311254 (1), 17939755 (1) (see all 6)
    neurodegenerative diseases 81.1 9 16461359 (1), 11606565 (1), 11487572 (1), 17939755 (1) (see all 8)
    machado-joseph disease 80.3 1 9292723 (1)
    spinocerebellar ataxia type 7 75.2 1 11487572 (1)
    neurodegeneration 70.1 2 17447526 (1), 14622574 (1)
    spinocerebellar degenerations 69.5 1 11511401 (1)
    promyelocytic leukemia 55.9 1 16461359 (1)
    parkinson disease 39.6 1 11511401 (1)


    Export disorders for CHERP gene to outside databases

    Publications
    for CHERP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHERP gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with CHERP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation. (PubMed id 10794731)1, 2, 3, 9 Laplante J.M....Feinstein M.B. (2000)
    2. Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. (PubMed id 8896557)1, 2, 3 Imbert G.... Brice A. (1996)
    3. Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes. (PubMed id 12656674)1, 2, 9 O'Rourke F.A.... Feinstein M.B. (2003)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for CHERP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing CHERP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10523 HGNC: 16930 AceView: CHERP Ensembl:ENSG00000085872 euGenes: HUgn10523
    ECgene: CHERP Kegg: 10523 H-InvDB: CHERP

    Other Databases showing CHERP gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CHERP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHERP Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CHERP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CHERP gene:
    Search GeneIP for patents involving CHERP

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