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Aliases for CHERP Gene

Aliases for CHERP Gene

  • Calcium Homeostasis Endoplasmic Reticulum Protein 2 3
  • SR-Related CTD-Associated Factor 6 3 4
  • ERPROT 213-21 3 4
  • SCAF6 3 4
  • SR-Related CTD Associated Factor 6 3
  • Protein With Polyglutamine Repeat 3
  • ERPROT213-21 3
  • DAN16 3
  • DAN26 4
  • SRA1 3

External Ids for CHERP Gene

Previous GeneCards Identifiers for CHERP Gene

  • GC19M017122
  • GC19M017020
  • GC19M016473
  • GC19M016629
  • GC19M016197

Summaries for CHERP Gene

GeneCards Summary for CHERP Gene

CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein) is a Protein Coding gene. Diseases associated with CHERP include spinocerebellar ataxia 7 and spinocerebellar ataxia 2. Among its related pathways are GPCR Pathway and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for CHERP Gene

  • Involved in calcium homeostasis, growth and proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHERP Gene

Genomics for CHERP Gene

Regulatory Elements for CHERP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHERP Gene

16,517,889 bp from pter
16,542,530 bp from pter
24,642 bases
Minus strand

Genomic View for CHERP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHERP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHERP Gene

Proteins for CHERP Gene

  • Protein details for CHERP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Calcium homeostasis endoplasmic reticulum protein
    Protein Accession:
    Secondary Accessions:
    • O00302
    • Q4G0Y5
    • Q8WU30
    • Q99492

    Protein attributes for CHERP Gene

    916 amino acids
    Molecular mass:
    103702 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB53327.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH21294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA69591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA69591.1; Type=Frameshift; Positions=450; Evidence={ECO:0000305};

neXtProt entry for CHERP Gene

Proteomics data for CHERP Gene at MOPED

Post-translational modifications for CHERP Gene

  • Ubiquitination at Lys 177
  • Modification sites at PhosphoSitePlus

Other Protein References for CHERP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHERP Gene

Domains & Families for CHERP Gene

Gene Families for CHERP Gene

Suggested Antigen Peptide Sequences for CHERP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CID domain.
  • Contains 1 SURP motif repeat.
  • Contains 1 CID domain.
  • Contains 1 G-patch domain.
  • Contains 1 SURP motif repeat.
genes like me logo Genes that share domains with CHERP: view

Function for CHERP Gene

Molecular function for CHERP Gene

UniProtKB/Swiss-Prot Function:
Involved in calcium homeostasis, growth and proliferation.

Gene Ontology (GO) - Molecular Function for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 22365833
GO:0044325 ion channel binding IPI 21454501
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CHERP: view
genes like me logo Genes that share phenotypes with CHERP: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CHERP Gene

Localization for CHERP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHERP Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. {ECO:0000269 PubMed:10794731, ECO:0000269 PubMed:12656674, ECO:0000269 PubMed:8010949}.

Subcellular locations from

Jensen Localization Image for CHERP Gene COMPARTMENTS Subcellular localization image for CHERP gene
Compartment Confidence
endoplasmic reticulum 4
nucleus 2

Gene Ontology (GO) - Cellular Components for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10794731
GO:0016020 membrane IDA 19946888
GO:0033017 sarcoplasmic reticulum membrane ISS --
GO:0048471 perinuclear region of cytoplasm IDA 12656674
genes like me logo Genes that share ontologies with CHERP: view

Pathways & Interactions for CHERP Gene

SuperPathways for CHERP Gene

Superpath Contained pathways
1 GPCR Pathway
2 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with CHERP: view

Pathways by source for CHERP Gene

1 Qiagen pathway for CHERP Gene
1 KEGG pathway for CHERP Gene

Gene Ontology (GO) - Biological Process for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0006874 cellular calcium ion homeostasis IDA 10794731
GO:0007399 nervous system development TAS 8896557
GO:0008285 negative regulation of cell proliferation IDA 10794731
GO:0051209 release of sequestered calcium ion into cytosol IMP 12656674
genes like me logo Genes that share ontologies with CHERP: view

No data available for SIGNOR curated interactions for CHERP Gene

Drugs & Compounds for CHERP Gene

(3) Drugs for CHERP Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Testosterone Approved, Investigational Pharma Endogenous androgen receptor agonist 453
Calcium Nutra 0
glutamine Nutra 137
genes like me logo Genes that share compounds with CHERP: view

Transcripts for CHERP Gene

Unigene Clusters for CHERP Gene

Calcium homeostasis endoplasmic reticulum protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHERP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHERP Gene

No ASD Table

Relevant External Links for CHERP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHERP Gene

mRNA expression in normal human tissues for CHERP Gene

Protein differential expression in normal tissues from HIPED for CHERP Gene

This gene is overexpressed in Lymph node (8.6) and Fetal ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHERP Gene

SOURCE GeneReport for Unigene cluster for CHERP Gene Hs.740364

mRNA Expression by UniProt/SwissProt for CHERP Gene

Tissue specificity: Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and in cultured HEL and Dami cells.
genes like me logo Genes that share expression patterns with CHERP: view

Protein tissue co-expression partners for CHERP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHERP Gene

Orthologs for CHERP Gene

This gene was present in the common ancestor of animals.

Orthologs for CHERP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHERP 35
  • 91.08 (n)
  • 97.16 (a)
  • 97 (a)
(Canis familiaris)
Mammalia CHERP 35
  • 90.28 (n)
  • 98.25 (a)
  • 95 (a)
(Mus musculus)
Mammalia Cherp 35
  • 85.12 (n)
  • 93.98 (a)
Cherp 16
Cherp 36
  • 93 (a)
(Pan troglodytes)
Mammalia CHERP 35
  • 95.3 (n)
  • 94.82 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Cherp 35
  • 86.29 (n)
  • 95.4 (a)
(Monodelphis domestica)
Mammalia CHERP 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia CHERP 36
  • 95 (a)
(Gallus gallus)
Aves CHERP 35
  • 74.75 (n)
  • 87.26 (a)
  • 82 (a)
(Anolis carolinensis)
Reptilia CHERP 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia cherp 35
  • 72.21 (n)
  • 81.16 (a)
African clawed frog
(Xenopus laevis)
Amphibia cherp-prov 35
(Danio rerio)
Actinopterygii cherp 35
  • 72.76 (n)
  • 75.11 (a)
iktdsubc_2h12 35
cherp 36
  • 72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9770 35
fruit fly
(Drosophila melanogaster)
Insecta scaf6 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea tag-65 36
  • 27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2440 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5488 36
  • 39 (a)
Species with no ortholog for CHERP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHERP Gene

Gene Tree for CHERP (if available)
Gene Tree for CHERP (if available)

Paralogs for CHERP Gene

No data available for Paralogs for CHERP Gene

Variants for CHERP Gene

Sequence variations from dbSNP and Humsavar for CHERP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1043447 -- 16,532,678(-) CTCCG(C/G)AACCG synonymous-codon, reference
rs1043448 - 16,532,677(-) TCCGG(A/C)ACCGC reference, missense
rs1043481 -- 16,523,139(-) GGCCC(A/G)CCCCA reference, synonymous-codon
rs1127281 -- 16,530,882(-) ACCAC(A/T)GCCAG splice-acceptor-variant
rs2112864 -- 16,541,742(-) CCACA(C/G)GATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHERP Gene

Variant ID Type Subtype PubMed ID
nsv911167 CNV Loss 21882294

Variation tolerance for CHERP Gene

Residual Variation Intolerance Score: 4.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHERP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHERP Gene

Disorders for CHERP Gene

MalaCards: The human disease database

(4) MalaCards diseases for CHERP Gene - From: NovoSeek and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 7
  • spinocerebellar ataxia type 7
spinocerebellar ataxia 2
  • amyotrophic lateral sclerosis 13
spinocerebellar ataxia 1
  • spinocerebellar ataxia type 1
huntington disease
  • congenital anomalies of kidney and urinary tract 2
- elite association
Search CHERP in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHERP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CHERP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHERP Gene

Publications for CHERP Gene

  1. Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation. (PMID: 10794731) LaPlante J.M. … Feinstein M.B. (Biochem. J. 2000) 2 23 67
  2. A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation. (PMID: 20159555) Hageman J. … Kampinga H.H. (Mol. Cell 2010) 23 67
  3. Polyglutamine toxicity in non-neuronal cells. (PMID: 20231860) Bradford J.W. … Li X.J. (Cell Res. 2010) 23 67
  4. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. (PMID: 20348093) Wang A.M. … Lieberman A.P. (J. Biol. Chem. 2010) 23 67
  5. SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition. (PMID: 19240033) Noh J.-Y. … Jung Y.-K. (J. Biol. Chem. 2009) 23 67

Products for CHERP Gene

Sources for CHERP Gene

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