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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHERP Gene

protein-coding   GIFtS: 54
GCID: GC19M016629

Calcium Homeostasis Endoplasmic Reticulum Protein

Alzheimer's & Parkinson's Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Calcium Homeostasis Endoplasmic Reticulum Protein1 2     ERPROT213-212
SCAF62 3     SRA12
ERPROT 213-212 3     Protein With Polyglutamine Repeat2
SR-Related CTD-Associated Factor 62 3     SR-Related CTD Associated Factor 62
DAN162     DAN263

External Ids:    HGNC: 169301   Entrez Gene: 105232   Ensembl: ENSG000000858727   UniProtKB: Q8IWX83   

Export aliases for CHERP gene to outside databases

Previous GC identifers: GC19M017122 GC19M017020 GC19M016473 GC19M016489 GC19M016197


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CHERP Gene: 
CHERP (calcium homeostasis endoplasmic reticulum protein) is a protein-coding gene. Diseases associated with CHERP include spinocerebellar ataxia type 8, and spinocerebellar ataxia type 3, and among its related super-pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include ion channel binding and RNA binding.

UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8
Function: Involved in calcium homeostasis, growth and proliferation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011295.11  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHERP gene promoter:
         NF-1   LHX3b/Lhx3b   Pax-6   Pax-2   MIF-1   Pax-2a   XBP-1   GATA-2   RORalpha1   LHX3a/Lhx3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHERP promoter sequence
   Search SABiosciences Chromatin IP Primers for CHERP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHERP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.1   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.1

CHERP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHERP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M016629:  view genomic region     (about GC identifiers)

Start:
16,628,700 bp from pter      End:
16,653,341 bp from pter
Size:
24,642 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8 (See protein sequence)
Recommended Name: Calcium homeostasis endoplasmic reticulum protein  
Size: 916 amino acids; 103702 Da
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Distributed throughout
the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat
cells. Colocalizes with ITPR1
Sequence caution: Sequence=AAB53327.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH21294.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA69591.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAA69591.1; Type=Frameshift;
Positions=450;
Secondary accessions: O00302 Q4G0Y5 Q8WU30 Q99492

Explore the universe of human proteins at neXtProt for CHERP: NX_Q8IWX8

Explore proteomics data for CHERP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IWX8

  • CHERP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHERP Protein Expression
    REFSEQ proteins: NP_006378.3  
    ENSEMBL proteins: 
     ENSP00000439856   ENSP00000198939  

    Human Recombinant Protein Products for CHERP: 
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    OriGene Protein Over-expression Lysate for CHERP
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CHERP
    GenScript Custom Purified and Recombinant Proteins Services for CHERP
    Novus Biologicals CHERP Proteins
    Novus Biologicals CHERP Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHERP 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10794731
    GO:0033017sarcoplasmic reticulum membrane ISS--
    GO:0048471perinuclear region of cytoplasm IDA12656674

    CHERP for ontologies           About GeneDecksing



    CHERP Antibody Products: 
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    Cloud-Clone Corp. Antibodies for CHERP 
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    Assay Products for CHERP: 
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    Cloud-Clone Corp. ELISAs for CHERP 
    Cloud-Clone Corp. CLIAs for CHERP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPATCH: G patch domain containing

    5 InterPro protein domains:
     IPR006569 CID_dom
     IPR000061 Surp
     IPR006903 RNA_pol_II-bd
     IPR000467 G_patch_dom
     IPR008942 ENTH_VHS

    Graphical View of Domain Structure for InterPro Entry Q8IWX8

    ProtoNet protein and cluster: Q8IWX8

    3 Blocks protein domains:
    IPB000061 SWAP/Surp
    IPB000467 D111/G-patch domain
    IPB006569 Regulation of nuclear pre-mRNA protein


    UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8
    Similarity: Contains 1 CID domain
    Similarity: Contains 1 G-patch domain
    Similarity: Contains 1 SURP motif repeat


    CHERP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHERP_HUMAN, Q8IWX8
    Function: Involved in calcium homeostasis, growth and proliferation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0044325ion channel binding IPI--
         
    CHERP for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHERP:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHERP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHERP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHERP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHERP 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHERP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CHERP (see all 9):
    hsa-miR-3671 hsa-miR-607 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548v hsa-miR-16-1* hsa-miR-551b* hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidCHERP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHERP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHERP

    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CHERP 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHERP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHERP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    Spliceosome0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for CHERP):
        Spliceosome


    CHERP for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHERP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/37 Interacting proteins for CHERP (Q8IWX82, 3 ENSP000001989394) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LUC7LQ9NQ292, ENSP000002938724MINT-8334769 MINT-8331481 STRING: ENSP00000293872
    DHX8Q145622, ENSP000002624154MINT-8334648 MINT-8331448 STRING: ENSP00000262415
    U2AF2P263682, ENSP000003078634MINT-8334142 MINT-8331437 STRING: ENSP00000307863
    FRA10AC1Q70Z532, ENSP000003604884MINT-8331459 MINT-8334670 STRING: ENSP00000360488
    SNRNP27Q8WVK22, ENSP000002442274MINT-8331470 MINT-8334725 STRING: ENSP00000244227
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing IEA--
    GO:0006874cellular calcium ion homeostasis IDA10794731
    GO:0007399nervous system development TAS8896557
    GO:0008285negative regulation of cell proliferation IDA10794731
    GO:0051209release of sequestered calcium ion into cytosol IMP12656674

    CHERP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHERP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHERP

    1 HMDB Compound for CHERP    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    3 Novoseek inferred chemical compound relationships for CHERP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamine 89.4 189 17028181 (5), 12676955 (5), 11751688 (4), 15470501 (4) (see all 95)
    testosterone 12.6 1 11751688 (1)
    calcium 0 7 12656674 (2), 10794731 (1)

    Search CenterWatch for drugs/clinical trials and news about CHERP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHERP gene: 
    NM_006387.5  

    Unigene Cluster for CHERP:

    Calcium homeostasis endoplasmic reticulum protein
    Hs.740364  [show with all ESTs]
    Unigene Representative Sequence: NM_006387
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546361(uc010xpg.1 uc002nei.1) ENST00000198939 ENST00000597261
    ENST00000544299 ENST00000600432 ENST00000546538(uc002nej.3) ENST00000551747


    miRNA
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    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate CHERP (see all 9):
    hsa-miR-3671 hsa-miR-607 hsa-miR-27a hsa-miR-513a-5p hsa-miR-548v hsa-miR-16-1* hsa-miR-551b* hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidCHERP 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHERP
    Clone
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    GenScript: all cDNA clones in your preferred vector: CHERP (NM_006387)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHERP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHERP
    Sirion Biotech Customized lentivirus for stable overexpression of CHERP 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHERP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHERP

    Additional mRNA sequence: 

    AB209730.1 AF536542.1 AK296883.1 AK298408.1 BC001552.2 BC021294.2 U94836.2 Y08265.1 

    19 DOTS entries:

    DT.97804090  DT.95090896  DT.100781339  DT.318015  DT.97811429  DT.92445379  DT.92004744  DT.91652495 
    DT.99994208  DT.121500561  DT.100706502  DT.40132863  DT.95254795  DT.100883373  DT.101958784  DT.121500661 
    DT.95254782  DT.86837691  DT.97846751 

    24/361 AceView cDNA sequences (see all 361):

    AI858550 BE276629 BX331460 BU682502 AA131669 BM783902 BX106296 AA887727 
    CA394103 CR602259 BI029115 Z39812 BI820034 CB241570 AI685290 CF993915 
    H75745 BU839481 BI908372 BE279395 BQ434588 BM849488 AI262272 AW978303 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHERP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCAGCCTGG
    CHERP Expression
    About this image


    See CHERP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHERP

    SOURCE GeneReport for Unigene cluster: Hs.740364

    UniProtKB/Swiss-Prot: CHERP_HUMAN, Q8IWX8
    Tissue specificity: Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and
    in cultured HEL and Dami cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHERP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHERP gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cherp1 , 5 calcium homeostasis endoplasmic reticulum protein1, 5 85.74(n)1
    95.51(a)1
      8 (35.08 cM)5
    279671  NM_138585.31  NP_613051.31 
     724604895 
    chicken
    (Gallus gallus)
    Aves CHERP1 calcium homeostasis endoplasmic reticulum protein 76.79(n)
    89.62(a)
      420144  XM_001233543.2  XP_001233544.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHERP6
    Uncharacterized protein
    86(a)
    1 ↔ 1
    AAWZ02036422(6857-21185)
    African clawed frog
    (Xenopus laevis)
    Amphibia cherp-prov2 calcium homeostasis endoplasmic reticulum protein 76.24(n)    BC046715.1 
    zebrafish
    (Danio rerio)
    Actinopterygii iktdsubc_2h122 iktdsubc_2h12 77.12(n)   337851  AF536545.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta scaf61 BP1047 49.46(n)
    41.3(a)
      3346235  NM_001014589.3  NP_001014589.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tag-651 Protein TAG-65 39.46(n)
    30.47(a)
      179857  NM_073985.3  NP_506386.1 


    ENSEMBL Gene Tree for CHERP (if available)
    TreeFam Gene Tree for CHERP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/498 SNPs in CHERP are shown (see all 498)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433077671,2
    --16632665(+) CATAGC/TTGCTC 1 -- int10--------
    rs1829426641,2
    --16632684(+) ATGACA/GGTCAC 1 -- int10--------
    rs1876153471,2
    --16632856(+) CCTGGA/GGCCCC 1 -- int10--------
    rs1145574391,2
    F--16632876(+) ATCCTT/CCTTCT 1 -- int11Minor allele frequency- C:0.03WA 118
    rs124616081,2
    C,F,H--16632895(+) TCTGTC/TCTCCT 1 -- int115Minor allele frequency- T:0.05NS EA NA WA 1748
    rs557462581,2
    C,F--16632968(+) GGCTCC/TGTGAA 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1928905631,2
    --16633131(+) GTGGCA/GTGATC 1 -- int10--------
    rs1849522361,2
    --16633136(+) GTGATC/TTCGGC 1 -- int10--------
    rs1397264361,2
    --16633161(+) GCCTCC/TCGGGT 1 -- int10--------
    rs72510141,2
    C,A--16633261(+) GAGACG/AGGGTT 1 -- int11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for CHERP (16628700 - 16653341 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CHERP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911167CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHERP
    DNA2.0 Custom Variant and Variant Library Synthesis for CHERP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    20/21 diseases for CHERP (see all 21):    About MalaCards
    spinocerebellar ataxia type 8    spinocerebellar ataxia type 3    spinocerebellar ataxia type 7    spinocerebellar degeneration
    oculopharyngeal muscular dystrophy    hereditary ataxia    hepatic encephalopathy    machado-joseph disease
    spinal-bulbar muscular atrophy    huntington's disease    spinocerebellar ataxia    muscular atrophy
    ataxia    parkinson's disease    fanconi's anemia    muscular dystrophy
    anemia    hepatitis    retinitis    leukemia


    CHERP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/13 Novoseek inferred disease relationships for CHERP gene (see all 13)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spinocerebellar ataxias 84.9 4 15198995 (1), 16791428 (1), 11511401 (1), 16831871 (1)
    spinocerebellar ataxia type 1 83.1 1 10624951 (1)
    huntington disease 81.6 7 15198995 (1), 19240033 (1), 16311254 (1), 17939755 (1) (see all 6)
    neurodegenerative diseases 81.1 9 16461359 (1), 11606565 (1), 11487572 (1), 17939755 (1) (see all 8)
    machado-joseph disease 80.3 1 9292723 (1)
    spinocerebellar ataxia type 7 75.2 1 11487572 (1)
    neurodegeneration 70.1 2 17447526 (1), 14622574 (1)
    spinocerebellar degenerations 69.5 1 11511401 (1)
    promyelocytic leukemia 55.9 1 16461359 (1)
    parkinson disease 39.6 1 11511401 (1)


    Export disorders for CHERP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHERP gene, integrated from 9 sources (see all 131):
    (articles sorted by number of sources associating them with CHERP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation. (PubMed id 10794731)1, 2, 3, 9 Laplante J.M....Feinstein M.B. (2000)
    2. Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. (PubMed id 8896557)1, 2, 3 Imbert G.... Brice A. (1996)
    3. Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes. (PubMed id 12656674)1, 2, 9 O'Rourke F.A.... Feinstein M.B. (2003)
    4. Re-evaluation of the role of calcium homeostasis endop lasmic reticulum protein (CHERP) in cellular calcium signaling. (PubMed id 23148228)1 Lin-Moshier Y....Marchant J.S. (2013)
    5. Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress. (PubMed id 22751105)1 Chu L....Tomasson M.H. (2012)
    6. Dynamic protein-protein interaction wiring of the huma n spliceosome. (PubMed id 22365833)1 Hegele A....Stelzl U. (2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10523 HGNC: 16930 AceView: CHERP Ensembl:ENSG00000085872 euGenes: HUgn10523
    ECgene: CHERP Kegg: 10523 H-InvDB: CHERP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHERP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHERP gene:
    Search GeneIP for patents involving CHERP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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