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Aliases for CHERP Gene

Aliases for CHERP Gene

  • Calcium Homeostasis Endoplasmic Reticulum Protein 2 3 5
  • ERPROT 213-21 3 4
  • SCAF6 3 4
  • SR-Related CTD Associated Factor 6 3
  • SR-Related CTD-Associated Factor 6 4
  • Protein With Polyglutamine Repeat 3
  • ERPROT213-21 3
  • DAN16 3
  • DAN26 4
  • SRA1 3

External Ids for CHERP Gene

Previous GeneCards Identifiers for CHERP Gene

  • GC19M017122
  • GC19M017020
  • GC19M016473
  • GC19M016629
  • GC19M016197

Summaries for CHERP Gene

GeneCards Summary for CHERP Gene

CHERP (Calcium Homeostasis Endoplasmic Reticulum Protein) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding.

UniProtKB/Swiss-Prot for CHERP Gene

  • Involved in calcium homeostasis, growth and proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHERP Gene

Genomics for CHERP Gene

Regulatory Elements for CHERP Gene

Enhancers for CHERP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F016568 1.1 ENCODE 12.4 -29.7 -29662 7.6 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 C19orf44 SMIM7 ENSG00000269578 ENSG00000268743 TMEM38A ENSG00000268087 SIN3B ENSG00000267904 PLVAP CHERP
GH19F016577 0.2 ENCODE 12.3 -35.6 -35579 1.2 POLR2A EBF1 CHERP RN7SL146P ENSG00000141979 SMIM7 TMEM38A C19orf44 EPS15L1 PIR43667 GC19P018790
GH19F016492 0.6 ENCODE 12.1 +49.6 49609 0.8 MLX ARID4B ZNF48 YY1 FOS SP5 PPARG KAT8 SREBF1 MIER3 CHERP RN7SL146P CPAMD8 EPS15L1 CALR3
GH19F016489 0.8 Ensembl ENCODE 12.1 +53.4 53420 0.2 MLX ZFP64 FEZF1 THRB ZNF48 YY1 RARA SCRT2 KLF7 ZNF548 C19orf44 RN7SL146P CHERP ENSG00000269578 ENSG00000268743 CPAMD8 SMIM7 CALR3 EPS15L1
GH19F016607 1.1 Ensembl ENCODE 11.8 -71.4 -71371 13.0 HDGF PKNOX1 FEZF1 ZNF2 REST TSHZ1 ZNF623 TBX21 MYNN PBX2 C19orf44 EPS15L1 SMIM7 CALR3 SLC35E1 TMEM38A CHERP RN7SL146P CPAMD8 ENSG00000269044
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CHERP on UCSC Golden Path with GeneCards custom track

Promoters for CHERP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000215453 -70 2401 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for CHERP Gene

Chromosome:
19
Start:
16,517,889 bp from pter
End:
16,542,530 bp from pter
Size:
24,642 bases
Orientation:
Minus strand

Genomic View for CHERP Gene

Genes around CHERP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHERP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHERP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHERP Gene

Proteins for CHERP Gene

  • Protein details for CHERP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWX8-CHERP_HUMAN
    Recommended name:
    Calcium homeostasis endoplasmic reticulum protein
    Protein Accession:
    Q8IWX8
    Secondary Accessions:
    • O00302
    • Q4G0Y5
    • Q8WU30
    • Q99492

    Protein attributes for CHERP Gene

    Size:
    916 amino acids
    Molecular mass:
    103702 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB53327.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH21294.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA69591.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA69591.1; Type=Frameshift; Positions=450; Evidence={ECO:0000305};

neXtProt entry for CHERP Gene

Post-translational modifications for CHERP Gene

  • Ubiquitination at Lys 177
  • Modification sites at PhosphoSitePlus

Other Protein References for CHERP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for CHERP
  • Santa Cruz Biotechnology (SCBT) Antibodies for CHERP

No data available for DME Specific Peptides for CHERP Gene

Domains & Families for CHERP Gene

Gene Families for CHERP Gene

Suggested Antigen Peptide Sequences for CHERP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWX8

UniProtKB/Swiss-Prot:

CHERP_HUMAN :
  • Contains 1 CID domain.
  • Contains 1 SURP motif repeat.
Domain:
  • Contains 1 CID domain.
  • Contains 1 G-patch domain.
Similarity:
  • Contains 1 SURP motif repeat.
genes like me logo Genes that share domains with CHERP: view

Function for CHERP Gene

Molecular function for CHERP Gene

UniProtKB/Swiss-Prot Function:
Involved in calcium homeostasis, growth and proliferation.

Gene Ontology (GO) - Molecular Function for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005515 protein binding IPI 22365833
GO:0044325 ion channel binding IPI 21454501
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CHERP: view
genes like me logo Genes that share phenotypes with CHERP: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHERP Gene

Localization for CHERP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHERP Gene

Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Distributed throughout the cytoplasm and also localizes to the perinuclear region of both human erythroleukemia (HEL) cells and Jurkat cells. Colocalizes with ITPR1. {ECO:0000269 PubMed:10794731, ECO:0000269 PubMed:12656674, ECO:0000269 PubMed:8010949}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHERP Gene COMPARTMENTS Subcellular localization image for CHERP gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 10794731
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IDA 19946888
GO:0033017 sarcoplasmic reticulum membrane IEA,ISS --
GO:0048471 perinuclear region of cytoplasm IEA,IDA 12656674
genes like me logo Genes that share ontologies with CHERP: view

Pathways & Interactions for CHERP Gene

genes like me logo Genes that share pathways with CHERP: view

Pathways by source for CHERP Gene

Gene Ontology (GO) - Biological Process for CHERP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0006874 cellular calcium ion homeostasis IDA 10794731
GO:0007399 nervous system development TAS 8896557
GO:0008285 negative regulation of cell proliferation IDA 10794731
GO:0051209 release of sequestered calcium ion into cytosol IMP 12656674
genes like me logo Genes that share ontologies with CHERP: view

No data available for SIGNOR curated interactions for CHERP Gene

Drugs & Compounds for CHERP Gene

(3) Drugs for CHERP Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CHERP: view

Transcripts for CHERP Gene

Unigene Clusters for CHERP Gene

Calcium homeostasis endoplasmic reticulum protein:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHERP Gene

No ASD Table

Relevant External Links for CHERP Gene

GeneLoc Exon Structure for
CHERP
ECgene alternative splicing isoforms for
CHERP

Expression for CHERP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHERP Gene

Protein differential expression in normal tissues from HIPED for CHERP Gene

This gene is overexpressed in Lymph node (8.6) and Fetal ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHERP Gene



Protein tissue co-expression partners for CHERP Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHERP Gene:

CHERP

SOURCE GeneReport for Unigene cluster for CHERP Gene:

Hs.740364

mRNA Expression by UniProt/SwissProt for CHERP Gene:

Q8IWX8-CHERP_HUMAN
Tissue specificity: Expressed in brain, placenta, lung, liver, kidney, pancreas, cardiac and skeletal muscle, and in cultured HEL and Dami cells.
genes like me logo Genes that share expression patterns with CHERP: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHERP Gene

Orthologs for CHERP Gene

This gene was present in the common ancestor of animals.

Orthologs for CHERP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHERP 34 35
  • 95.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHERP 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHERP 34 35
  • 91.08 (n)
oppossum
(Monodelphis domestica)
Mammalia CHERP 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHERP 34 35
  • 90.28 (n)
rat
(Rattus norvegicus)
Mammalia Cherp 34
  • 86.29 (n)
mouse
(Mus musculus)
Mammalia Cherp 34 16 35
  • 85.12 (n)
chicken
(Gallus gallus)
Aves CHERP 34 35
  • 74.75 (n)
lizard
(Anolis carolinensis)
Reptilia CHERP 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cherp 34
  • 72.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia cherp-prov 34
zebrafish
(Danio rerio)
Actinopterygii cherp 34 35
  • 72.76 (n)
iktdsubc_2h12 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9770 34
fruit fly
(Drosophila melanogaster)
Insecta scaf6 35
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tag-65 35
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5488 35
  • 39 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2440 34
Species where no ortholog for CHERP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHERP Gene

ENSEMBL:
Gene Tree for CHERP (if available)
TreeFam:
Gene Tree for CHERP (if available)

Paralogs for CHERP Gene

No data available for Paralogs for CHERP Gene

Variants for CHERP Gene

Sequence variations from dbSNP and Humsavar for CHERP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10416645 -- 16,526,198(+) GGGAC(C/T)TTCAA intron-variant
rs10416753 -- 16,530,381(+) TGTTC(C/T)AGGAA intron-variant
rs10420418 -- 16,542,974(+) AACAT(C/G)CTCCT upstream-variant-2KB
rs1043447 -- 16,532,678(-) CTCCG(C/G)AACCG reference, synonymous-codon
rs1043448 -- 16,532,677(-) TCCGG(A/C)ACCGC reference, missense

Variation tolerance for CHERP Gene

Residual Variation Intolerance Score: 4.71% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 19.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHERP Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHERP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CHERP Gene

Disorders for CHERP Gene

Relevant External Links for CHERP

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHERP

No disorders were found for CHERP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHERP Gene

Publications for CHERP Gene

  1. Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation. (PMID: 10794731) LaPlante J.M. … Feinstein M.B. (Biochem. J. 2000) 2 3 4 22 64
  2. Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes. (PMID: 12656674) O'Rourke F.A. … Feinstein M.B. (Biochem. J. 2003) 3 4 22 64
  3. Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats. (PMID: 8896557) Imbert G. … Brice A. (Nat. Genet. 1996) 2 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for CHERP Gene

Sources for CHERP Gene

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