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CHEK2 Gene

protein-coding   GIFtS: 74
GCID: GC22M029083

Checkpoint Kinase 2

(Previous names: CHK2 (checkpoint, S.pombe) homolog, CHK2 checkpoint homolog...)
(Previous symbol: RAD53)
  See CHEK2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Checkpoint Kinase 21 2 3     CHK2 Checkpoint Homolog (S. Pombe)1
RAD531 2 3 5     HuCds12
CDS12 3 5     PP14252
CHK22 3 5     Checkpoint-Like Protein CHK22
Cds1 Homolog2 3     Serine/Threonine-Protein Kinase Chk22
CHK2 Checkpoint Homolog2 3     EC 2.7.11.13
hCds12 3     Hucds13
LFS22 5     EC 2.7.118
CHK2 (Checkpoint, S.Pombe) Homolog1     

External Ids:    HGNC: 166271   Entrez Gene: 112002   Ensembl: ENSG000001837657   OMIM: 6043735   UniProtKB: O960173   

Export aliases for CHEK2 gene to outside databases

Previous GC identifers: GC22M025779 GC22M027408 GC22M012048


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHEK2 Gene:
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical
cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor
suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to
DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the
encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to
stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein
interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this
gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated
with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to
sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of
serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Apr 2012)

GeneCards Summary for CHEK2 Gene:
CHEK2 (checkpoint kinase 2) is a protein-coding gene. Diseases associated with CHEK2 include breast and colorectal cancer, and chek2-related susceptibility to breast cancer. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity.

UniProtKB/Swiss-Prot: CHK2_HUMAN, O96017
Function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation
of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate
cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors
preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through
phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity
leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.
May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through
phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by
homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2)
through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the
phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate
inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce
degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the
transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic
spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in
some cancer cells

summary for CHEK2 Gene:
Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle.
Two subtypes have so far been identified, Chk1 and Chk2. They are essential components to delay cell cycle
progression in normal and damaged cells and can act at all three cell cycle checkpoints. Chks are activated
by phosphorylation. ATR kinase phosphorylates Chk1 in response to single strand DNA breaks and ATM kinase
phosphorylates Chk2 in response to double strand breaks. Chks phosphorylate Cdc25 phosphatase at Ser216,
which leads to Cdc25 sequestration in the cytoplasm. Therefore Cdc25 cannot remove the inhibitory
phosphorylation on mitotic promoting factor (MPF) and entry into mitosis is prohibited. In addition, Chks
have a role in the physiological stress of hypoxia/reoxygenation.

Gene Wiki entry for CHEK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHEK2 gene promoter:
         AML1a   p300   IRF-7A   STAT3   CUTL1   Pax-4a   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CHEK2 promoter sequence
   Search Chromatin IP Primers for CHEK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHEK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q12.1   Ensembl cytogenetic band:  22q12.1   HGNC cytogenetic band: 22q12.1

CHEK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHEK2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M029083:  view genomic region     (about GC identifiers)

Start:
29,083,731 bp from pter      End:
29,138,410 bp from pter
Size:
54,680 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CHK2_HUMAN, O96017 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Chk2  
Size: 543 amino acids; 60915 Da
Cofactor: Magnesium
Subunit: Homodimer. Homodimerization is part of the activation process but the dimer may dissociate following
activation. Interacts with PML. Interacts with TP53. Interacts with RB1; phosphorylates RB1. Interacts with
BRCA1. Interacts (phosphorylated at Thr-68) with MDC1; requires ATM-mediated phosphorylation of CHEK2. Interacts
with TP53BP1; modulates CHEK2 phosphorylation at Thr-68 in response to ionizing radiation. Interacts with CDC25A;
phosphorylates CDC25A and mediates its degradation in response to ionizing radiation. Interacts with CUL1;
mediates CHEK2 ubiquitination and regulation
Selected PDB 3D structures from and Proteopedia for CHEK2 (see all 38):
1GXC (3D)        2CN5 (3D)        2CN8 (3D)        2W0J (3D)        2W7X (3D)        2WTC (3D)    
Secondary accessions: A8K3Y9 B7ZBF3 B7ZBF4 B7ZBF5 Q6QA03 Q6QA04 Q6QA05 Q6QA06 Q6QA07 Q6QA08
Q6QA10 Q6QA11 Q6QA12 Q6QA13 Q9HBS5 Q9HCQ8 Q9UGF0 Q9UGF1
Alternative splicing: 13 isoforms:  O96017-1   O96017-2   O96017-3   O96017-4   O96017-5   O96017-6   O96017-7   O96017-8   
O96017-9   O96017-10   O96017-11   O96017-12   O96017-13   (Lacks enzymatic activity)

Explore the universe of human proteins at neXtProt for CHEK2: NX_O96017

Explore proteomics data for CHEK2 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylated at Ser-73 by PLK3 in response to DNA damage, promoting phosphorylation at Thr-68 by
    ATM and the G2/M transition checkpoint. Phosphorylation at Thr-68 induces homodimerization. Autophosphorylates at
    Thr-383 and Thr-387 in the T-loop/activation segment upon dimerization to become fully active and phosphorylate
    its substrates like for instance CDC25C. DNA damage-induced autophosphorylation at Ser-379 induces CUL1-mediated
    ubiquitination and regulates the pro-apoptotic function. Phosphorylation at Ser-456 also regulates
    ubiquitination. Phosphorylated by PLK41
  • Ubiquitinated. CUL1-mediated ubiquitination regulates the pro-apoptotic function. Ubiquitination may also regulate
    protein stability. Ubiquitinated by RNF8 via 'Lys-48'-linked ubiquitination1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for CHEK2 (O96017)
     IKITDFG  YLAPEVL  RDLKPEN 


    See CHEK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001005735.1  NP_001244316.1  NP_009125.1  NP_665861.1  

    ENSEMBL proteins: 
     ENSP00000416721   ENSP00000394430   ENSP00000402225   ENSP00000385747   ENSP00000329178  
     ENSP00000386087   ENSP00000372023   ENSP00000404567   ENSP00000412901   ENSP00000404400  
     ENSP00000384919   ENSP00000384835   ENSP00000397478   ENSP00000403659   ENSP00000390244  
     ENSP00000396903   ENSP00000408065   ENSP00000387451   ENSP00000381099   ENSP00000329012  
     ENSP00000372021   ENSP00000372006   ENSP00000442458   ENSP00000372007  
    Reactome Protein details: O96017

    CHEK2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CHEK2 Protein
    R&D Systems Recombinant & Natural Proteins for CHEK2 (Chk2)
    Enzo Life Sciences proteins for CHEK2
    OriGene Purified Protein for CHEK2
    OriGene Protein Over-expression Lysate for CHEK2
    OriGene MassSpec for CHEK2
    OriGene Custom Protein Services for CHEK2
    GenScript Custom Purified and Recombinant Proteins Services for CHEK2
    Novus Biologicals CHEK2 Proteins
    Novus Biologicals CHEK2 Lysates
    Sino Biological Recombinant Protein for CHEK2
    Sino Biological Cell Lysate for CHEK2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHEK2

     
    Search eBioscience for Proteins for CHEK2 

     
    antibodies-online proteins for CHEK2 (6 products) 

     
    antibodies-online peptides for CHEK2

    CHEK2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CHEK2
    R&D Systems Antibodies for CHEK2 (Chk2)
    Cell Signaling Technology (CST) Antibodies for CHEK2  (Chk2)
    OriGene Antibodies for CHEK2
    OriGene Custom Antibody Services for CHEK2
    Novus Biologicals CHEK2 Antibodies
    Abcam antibodies for CHEK2
    Cloud-Clone Corp. Antibodies for CHEK2
    ThermoFisher Antibody for CHEK2
    antibodies-online antibodies for CHEK2 (340 products) 

    CHEK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHEK2
    R&D Systems ELISAs for CHEK2 (Chk2)         (see all)
    GenScript Custom Assay Services for CHEK2
    Cell Signaling Technology (CST) Sandwich ELISA Kits for CHEK2 (Chk2)
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHEK2
    Cloud-Clone Corp. CLIAs for CHEK2
    Search eBioscience for ELISAs for CHEK2 
    antibodies-online kits for CHEK2 (7 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: checkpoint kinase 2
    RAD53 family

    Selected InterPro protein domains (see all 6):
     IPR008984 SMAD_FHA_domain
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O96017

    ProtoNet protein and cluster: O96017

    1 Blocks protein domain: IPB000253 Forkhead-associated (FHA)

    UniProtKB/Swiss-Prot: CHK2_HUMAN, O96017
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with CHEK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHK2_HUMAN, O96017
    Function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation
    of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate
    cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors
    preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through
    phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity
    leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.
    May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through
    phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by
    homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2)
    through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the
    phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate
    inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce
    degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the
    transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic
    spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in
    some cancer cells
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated through phosphorylation at Thr-68 by ATM in response to DNA double-strand breaks.
    Activation is modulated by several mediators including MDC1 and TP53BP1. Induces homodimerization with exchange
    of the T-loop/activation segment between protomers and transphosphorylation of the protomers. The
    autophosphorylated kinase dimer is fully active. Negatively regulated by PPM1D through dephosphorylation of
    Thr-68

         Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.11

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS9836640
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI11298456
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CHEK2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for CHEK2:
     Decreased substrate adherent c  Decreased telomerase activity  Increased apoptosis 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Chek2):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     tumorigenesis 

    Find genes that share phenotypes with CHEK2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CHEK2: Chek2tm1Nmt Chek2tm1Mak

       genOway: Develop your customized and physiologically relevant rodent model for CHEK2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHEK2:
    hsa-mir-324-5p (MIRT043107), hsa-mir-335-5p (MIRT019089)

    Block miRNA regulation of human, mouse, rat CHEK2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CHEK2
    SwitchGear 3'UTR luciferase reporter plasmidCHEK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHEK2
    Predesigned siRNA for gene silencing in human, mouse, rat CHEK2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHEK2

    Clone
    Products:
         
    OriGene clones in human, mouse for CHEK2 (see all 18)
    OriGene ORF clones in mouse, rat for CHEK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CHEK2 (NM_007194)
    Sino Biological Human cDNA Clone for CHEK2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHEK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHEK2
    Addgene plasmids for CHEK2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHEK2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHEK2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHEK2

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12057) for CHEK2 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHK2_HUMAN, O96017: Isoform 2: Nucleus. Note=Isoform 10 is present throughout the cell
    CHK2_HUMAN, O96017: Isoform 4: Nucleus
    CHK2_HUMAN, O96017: Isoform 7: Nucleus
    CHK2_HUMAN, O96017: Isoform 9: Nucleus
    CHK2_HUMAN, O96017: Isoform 12: Nucleus
    CHK2_HUMAN, O96017: Nucleus, PML body. Nucleus, nucleoplasm. Note=Recruited into PML bodies together with TP53
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781colocalizes with chromosome, telomeric region IDA15149599
    GO:0005654nucleoplasm TAS--
    GO:0016605PML body IDA12402044

    Find genes that share ontologies with CHEK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHEK2 About   (see all 29)  
    See pathways by source

    SuperPathContained pathways About
    1Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    2p53 signaling pathway
    DNA damage response0.41
    p53 signaling pathway0.41
    3p53 Signaling
    p53 Signaling0.38
    p53 Pathway0.38
    4CDK-mediated phosphorylation and removal of Cdc6
    p53-Independent DNA Damage Response0.91
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin Mediated Degradation of Phosphorylated Cdc25A0.91
    Cell Cycle Checkpoints0.58
    p53-Independent G1/S DNA damage checkpoint0.91
    5Apoptotic Pathways in Synovial Fibroblasts
    Mitochondrial Apoptosis0.85
    p53 Mediated Apoptosis0.84
    Cellular Apoptosis Pathway0.85


    Find genes that share SuperPaths with CHEK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CHEK2 (see all 12)
        BRCA1 Pathway
    Mitochondrial Apoptosis
    Molecular Mechanisms of Cancer
    p53 Mediated Apoptosis
    ATM Pathway

    2 Cell Signaling Technology (CST) Pathways for CHEK2
        Cell Cycle / Checkpoint Control
    DNA Damage

    1 Tocris Bioscience Pathway for CHEK2
        Apoptosis Pathway

    Selected GeneGo (Thomson Reuters) Pathways for CHEK2 (see all 6)
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage ATM/ATR regulation of G1/S checkpoint
    Cell cycle Regulation of G1/S transition (part 1)
    DNA damage Role of SUMO in p53 regulation
    DNA damage DNA-damage-induced responses

    Selected BioSystems Pathways for CHEK2 (see all 9)
        DNA damage response
    Cell cycle
    Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Prostate Cancer

    1 Sino Biological Pathway for CHEK2
        p53 Pathway

    2 Reactome Pathways for CHEK2
        Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
    G2/M DNA damage checkpoint

    1 PharmGKB Pathway for CHEK2
        Busulfan Pathway, Pharmacodynamics

    3 Kegg Pathways  (Kegg details for CHEK2):
        Cell cycle
    p53 signaling pathway
    HTLV-I infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHEK2 (see all 8): 
              DNA Damage Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat
              Cellular Senescence in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CHEK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHEK2 (O960171, 2, 3 ENSP000003720234) via UniProtKB, MINT, STRING, and/or I2D (see all 414)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC1P188871, 2, 3, ENSP000002628874EBI-1180783,EBI-947466 MINT-7295039 MINT-7294980 MINT-7294997 MINT-7294787 MINT-7295015 MINT-7295027 MINT-7294756 MINT-7294958 I2D: score=1 STRING: ENSP00000262887
    PER3P566451, 2, 3, ENSP000003550314EBI-1180783,EBI-2827813 MINT-8052850 MINT-8052875 I2D: score=1 STRING: ENSP00000355031
    MDM2Q009872, 3, ENSP000004172814MINT-58600 MINT-58601 MINT-58598 MINT-58602 MINT-58599 MINT-58604 I2D: score=3 STRING: ENSP00000417281
    KPNA2P522922, 3, ENSP000003324554MINT-62312 MINT-62310 MINT-62309 MINT-62308 MINT-62311 MINT-62313 I2D: score=2 STRING: ENSP00000332455
    TP53P046372, 3, ENSP000002693054MINT-58603 MINT-13742 MINT-6806523 I2D: score=4 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077DNA damage checkpoint TAS10617473
    GO:0000086G2/M transition of mitotic cell cycle IMP16481012
    GO:0006302double-strand break repair IMP18317453
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA12717439

    Find genes that share ontologies with CHEK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for CHEK2
    5 ApexBio Compounds for CHEK2     About this table
    CompoundAction CAS #
    AZD7762inhibitor of checkpoint kinases (Chks) [860352-01-8]
    CCT241533 hydrochloridepotent serine/threonine checkpoint kinase (Chk2) inhibitor. [1431697-96-9]
    CHIR-124potent inhibitor of Chk1[405168-58-3]
    LY2603618highly selective Chk 1 inhibitor[911222-45-2]
    MK-8776 (SCH-900776)potent and functionally selective inhibitor targeting Chk1[891494-63-6]

    Compounds for CHEK2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SB 218078Inhibitor of checkpoint kinase 1 (Chk1)[135897-06-2]
    NSC 109555 ditosylateSelective Chk2 inhibitor[66748-43-4]
    PF 477736Selective Chk1 inhibitor[952021-60-2]
    TCS 2312Potent Chk1 inhibitor[838823-31-7]

    3 HMDB Compounds for CHEK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    Selected Novoseek inferred chemical compound relationships for CHEK2 gene (see all 39)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    debromohymenialdisine 90.9 9 15078995 (1), 19177354 (1), 16794575 (1), 17616632 (1) (see all 6)
    sn 38 60.7 3 15699047 (1), 15213307 (1), 16535772 (1)
    caffeine 56.6 12 15620706 (2), 14757171 (1), 19536869 (1), 19705844 (1) (see all 10)
    neocarzinostatin 52 4 12386164 (2), 12654916 (1)
    threonine 51.4 16 12805407 (2), 18287812 (2), 19879149 (1), 16596250 (1) (see all 12)
    camptothecin 51.3 6 15699047 (2), 16905549 (1), 19557000 (1), 16150728 (1) (see all 5)
    irofulven 49.3 15 17118344 (5), 15269203 (5)
    aphidicolin 46.2 3 16732333 (1), 17118344 (1)
    se-methylselenocysteine 43 2 15213307 (1), 16535772 (1)
    serine 41.3 15 19879149 (1), 16596250 (1), 16940182 (1), 12663536 (1) (see all 13)



    Find genes that share compounds with CHEK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

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    REFSEQ mRNAs for CHEK2 gene (4 alternative transcripts): 
    NM_001005735.1  NM_001257387.1  NM_007194.3  NM_145862.2  

    Unigene Cluster for CHEK2:

    Checkpoint kinase 2
    Hs.291363  [show with all ESTs]
    Unigene Representative Sequence: AF217975
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000434810 ENST00000456369 ENST00000416671 ENST00000404276 ENST00000328354
    ENST00000472807 ENST00000405598 ENST00000382580(uc003adt.1) ENST00000448511
    ENST00000417588 ENST00000433728 ENST00000403642 ENST00000402731 ENST00000447421
    ENST00000433028 ENST00000464581 ENST00000491919 ENST00000425190
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHEK2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CHEK2
    SwitchGear 3'UTR luciferase reporter plasmidCHEK2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CHEK2
    Predesigned siRNA for gene silencing in human, mouse, rat CHEK2
    Clone
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    OriGene clones in human, mouse for CHEK2 (see all 18)
    OriGene ORF clones in mouse, rat for CHEK2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CHEK2 (NM_007194)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHEK2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHEK2
    Addgene plasmids for CHEK2 
    Primer
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    OriGene qPCR primer pairs and template standards for CHEK2
    OriGene qSTAR qPCR primer pairs in human, mouse for CHEK2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHEK2
      QuantiTect SYBR Green Assays in human, mouse, rat CHEK2
      QuantiFast Probe-based Assays in human, mouse, rat CHEK2
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-12057) for CHEK2 

    Additional mRNA sequence: 

    AB040105.1 AB164374.1 AF086904.1 AF096279.1 AF174135.1 AF217975.1 AJ131197.1 AJ783839.1 
    AK289360.1 AK290754.1 AY551295.1 AY551297.1 AY551299.1 AY551303.1 AY551304.1 BC004207.2 
    CR456418.1 

    17 DOTS entries:

    DT.92436481  DT.100881584  DT.100881588  DT.120637880  DT.40232891  DT.92436482  DT.401799  DT.92436483 
    DT.97779954  DT.100753434  DT.100881593  DT.102832620  DT.97839203  DT.100734571  DT.100842973  DT.100695166 
    DT.102832622 

    Selected AceView cDNA sequences (see all 54):

    BQ642442 AI141716 BM811398 BU069809 AA804625 AI796137 BQ054405 BC000004 
    BC065569 AI203804 AI826906 BI518530 NM_172002 CR456462 CB046828 BU195420 
    AI739537 BE327697 BU857730 BU858060 AW732206 BM852301 H93680 AI091767 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHEK2 (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
    SP1:                          -     -                                               -     -                 -                                                   
    SP2:                                            -     -                             -                       -                                                   
    SP3:                                            -     -                             -     -                 -                                                   
    SP4:                                            -     -                 -     -           -                 -                                                   
    SP5:                                            -     -                             -     -                 -                                         -     -   

    ExUns: 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                                                
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for CHEK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHEK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGCAGTGC
    CHEK2 Expression
    About this image

    CHEK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHEK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.291363

    UniProtKB/Swiss-Prot: CHK2_HUMAN, O96017
    Tissue specificity: High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low
    expression is found in other tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CHEK2 (see all 8): 
              DNA Damage Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat
              Cell Cycle in human mouse rat
              Cellular Senescence in human mouse rat
              Telomeres & Telomerase in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CHEK2
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    QuantiFast Probe-based Assays in human, mouse, rat CHEK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHEK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHEK2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chek21 , 5 checkpoint kinase 21, 5 84.49(n)1
    87.58(a)1
      5 (53.73 cM)5
    508831  NM_016681.31  NP_057890.11 
     1108400175 
    chicken
    (Gallus gallus)
    Aves CHEK21 checkpoint kinase 2 71.09(n)
    71.52(a)
      768913  NM_001080107.1  NP_001073576.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Cds12 protein kinase Cds1 76.34(n)    AF326574.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa66f082 wufa66f08 71.81(n)   336998  AF265346.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lok1 , 3 cell cycle checkpoint protein
    serine/threonine more3
    loki1
    42(a)3
    49.1(n)1
    42.16(a)1
      2 38B23
    352881  NM_165318.21  NP_724241.11 
    worm
    (Caenorhabditis elegans)
    Secernentea chk-21 , 3 chk-21 34(a)
    (best of 2)3
    45.36(n)1
    36.79(a)1
      V(19901240-19908076)3
    1803041  NM_001029100.31  NP_001024271.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DUN1(YDL101C)4
    RAD531
    Cell-cycle checkpoint serine-threonine kinase required more4
    RAD531
    49.06(n)1
    41.24(a)1
      4(281848-280307)4
    8559501  NP_015172.11  8514574 
     NP_010182.14 


    ENSEMBL Gene Tree for CHEK2 (if available)
    TreeFam Gene Tree for CHEK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHEK2 gene
    Selected SIMAP similar genes for CHEK2 using alignment to 12 protein entries:     CHK2_HUMAN (see all proteins) (see all similar genes):
    CHK2    AHSA1    OK/SW-cl.41    ZNF85    CLTA    TM4SF19
    C14orf105    STK32A    HUNK    ZNF66    CAMK1D    CAMK1G
    KIN27    PRKAA1    CAMK1    PRKD2    SEPSECS    ULK3

    Find genes that share paralogs with CHEK2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CHEK2 (see all 7)
    PGOHUM00000238744 PGOHUM00000246957 PGOHUM00000248821 PGOHUM00000262934 PGOHUM00000246381


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHEK2 (see all 1389)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436117471,2,,4
    C,FProstate cancer (PC)4 --13017518(+) TCAGGC/TGTTTA 8 H R mis12Minor allele frequency- T:0.00NA EU 5873
    rs1219087011,2,,4
    CProstate cancer (PC)4 other113042643(-) ACGCCG/ATCCTT 7 /H /R mis1 ut511Minor allele frequency- A:0.00NA 4542
    rs1378530101,2,,4
    CProstate cancer (PC)4 other113042644(-) AACGCC/TGTCCT 7 R C mis1 ut510--------
    rs1378530091,2,,4
    CProstate cancer (PC)4 other113042646(-) AAAACA/GCCGTC 7 H R mis1 ut510--------
    rs771309271,2,,4
    C,FProstate cancer (PC)4 --13042647(+) ACGGCG/ATTTTC 7 /R /C mis1 ut511Minor allele frequency- A:0.00NA 4542
    rs178838621,2,,4
    C,FAn osteogenic sarcoma sample4 other113052086(-) AGAACC/TTGAGG 7 P L mis1 ut51 ese34Minor allele frequency- T:0.00NS NA EU 5467
    VAR_0191114
    Prostate cancer (PC)4--see VAR_0191112 I F mis40--------
    VAR_0191014
    An osteogenic sarcoma sample4--see VAR_0191012 A S mis40--------
    VAR_0085544
    Li-Fraumeni syndrome 2 (LFS2)4--see VAR_0085542 R W mis40--------
    VAR_0191134
    Prostate cancer (PC)4--see VAR_0191132 T P mis40--------

    HapMap Linkage Disequilibrium report for CHEK2 (29083731 - 29138410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CHEK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2661639CNV Deletion23128226
    nsv517951CNV Loss19592680
    nsv459867CNV Loss19166990
    nsv834169CNV Loss17160897
    esv22533CNV Gain19812545
    nsv9895CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): CHEK2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHEK2
    DNA2.0 Custom Variant and Variant Library Synthesis for CHEK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604373   
    OMIM disorders: 609265  259500  114480  176807  
    UniProtKB/Swiss-Prot: CHK2_HUMAN, O96017
  • Li-Fraumeni syndrome 2 (LFS2) [MIM:609265]: A highly penetrant familial cancer syndrome that in its
    classic form is defined by the existence of a proband affected by a sarcoma before 45 years with a first degree
    relative affected by any tumor before 45 years and another first degree relative with any tumor before 45 years
    or a sarcoma at any age. Other clinical definitions for LFS have been proposed (PubMed:8118819 and
    PubMed:8718514) and called Li-Fraumeni like syndrome (LFL). In these families affected relatives develop a
    diverse set of malignancies at unusually early ages. Four types of cancers account for 80% of tumors occurring in
    TP53 germline mutation carriers: breast cancers, soft tissue and bone sarcomas, brain tumors (astrocytomas) and
    adrenocortical carcinomas. Less frequent tumors include choroid plexus carcinoma or papilloma before the age of
    15, rhabdomyosarcoma before the age of 5, leukemia, Wilms tumor, malignant phyllodes tumor, colorectal and
    gastric cancers. Note=The disease is caused by mutations affecting the gene represented in this entry
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate
    cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of
    prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma,
    prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid
    cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. Note=Disease susceptibility
    is associated with variations affecting the gene represented in this entry
  • Osteogenic sarcoma (OSRC) [MIM:259500]: A sarcoma originating in bone-forming cells, affecting the ends
    of long bones. Note=The gene represented in this entry may be involved in disease pathogenesis
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast
    neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common
    type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated
    by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different
    families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry (PubMed:12094328)

  • Selected diseases for CHEK2 (see all 26):    
    About MalaCards
    breast and colorectal cancer    chek2-related susceptibility to breast cancer    chek2-related susceptibility to breast and colorectal cancer    li-fraumeni syndrome, chek2-related
    prostate cancer 4    prostate cancer, hereditary, 5    prostate cancer 3    prostate cancer, progression of
    breast cancer    osteosarcoma    bilateral breast cancer    li-fraumeni syndrome
    osteosarcoma, somatic    prostate cancer, somatic    t-cell prolymphocytic leukemia    familial prostate cancer
    breast-ovarian cancer, familial, 2    prostate cancer    prostate cancer, progression and metastasis of    pancreas adenocarcinoma

    3 diseases from the University of Copenhagen DISEASES database for CHEK2:
    Breast cancer     Li-Fraumeni syndrome     Ovarian cancer

    Find genes that share disorders with CHEK2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CHEK2 gene (see all 43)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 89.3 60 12192050 (3), 11085506 (2), 16905549 (2), 16322218 (2) (see all 42)
    li-fraumeni syndrome 81 22 11053450 (2), 14648717 (1), 11248330 (1), 11011113 (1) (see all 15)
    nijmegen breakage syndrome 72.6 2 11438675 (1), 20173316 (1)
    germ-line mutation 69.4 12 17661168 (2), 14701743 (1), 11479205 (1), 16452051 (1) (see all 10)
    cancer 61.2 96 15361833 (4), 16024600 (3), 19876921 (3), 11746983 (3) (see all 52)
    breast cancer 54.6 128 11461078 (5), 16671833 (5), 11857075 (5), 18085035 (4) (see all 50)
    bilateral breast cancer 50.8 2 19372713 (2)
    tumors 45.6 105 12393693 (5), 15942682 (4), 17178848 (4), 16437383 (3) (see all 49)
    colon carcinoma 42.3 2 15326376 (1), 15048074 (1)
    ovarian cancer 42 16 14507240 (3), 19338682 (2), 16596250 (1), 17380889 (1) (see all 9)

    Genetic Association Database (GAD): CHEK2
    Human Genome Epidemiology (HuGE) Navigator: CHEK2 (149 documents)

    Export disorders for CHEK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHEK2 gene, integrated from 10 sources (see all 744):
    (articles sorted by number of sources associating them with CHEK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of two mutations in the CHEK2 gene with breast cancer. (PubMed id 15810020)1, 2, 4, 9 Bogdanova N.... Doerk T. (Int. J. Cancer 2005)
    2. Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype. (PubMed id 15818573)1, 2, 4, 9 van Puijenbroek M.... Morreau H. (J. Pathol. 2005)
    3. A novel founder CHEK2 mutation is associated with increased prostate cancer risk. (PubMed id 15087378)1, 2, 4, 9 Cybulski C.... Lubinski J. (Cancer Res. 2004)
    4. CHEK2 variants associate with hereditary prostate cancer. (PubMed id 14612911)1, 2, 4, 9 Seppaelae E.H.... Schleutker J. (Br. J. Cancer 2003)
    5. CHEK2 variant I157T may be associated with increased breast cancer risk. (PubMed id 15239132)1, 2, 4, 9 Kilpivaara O.... Nevanlinna H. (Int. J. Cancer 2004)
    6. Limited relevance of the CHEK2 gene in hereditary breast cancer. (PubMed id 15095295)1, 2, 4, 9 Dufault M.R.... Arnold N. (Int. J. Cancer 2004)
    7. CHEK2 is a multiorgan cancer susceptibility gene. (PubMed id 15492928)1, 2, 4, 9 Cybulski C.... Lubinski J. (Am. J. Hum. Genet. 2004)
    8. Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women. (PubMed id 15535844)1, 2, 4, 9 Friedrichsen D.M....Ostrander E.A. (Breast Cancer Res. 2004)
    9. Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population. (PubMed id 15649950)1, 2, 4 Shaag A....King M.-C. (Hum. Mol. Genet. 2005)
    10. CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours. (PubMed id 12454775)1, 2, 4 Sodha N....Eeles R.A. (Br. J. Cancer 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11200 HGNC: 16627 AceView: HSC20 Ensembl:ENSG00000183765 euGenes: HUgn11200
    ECgene: CHEK2 Kegg: 11200 H-InvDB: CHEK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHEK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHEK2 Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=CHEK2[genesymbol]
    NIEHS-SNPshttp://egp.gs.washington.edu/data/chek2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHEK2 gene:
    Search GeneIP for patents involving CHEK2

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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Purified and/or Recombinant CHEK2 Protein
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     OriGene Antibodies for CHEK2   OriGene RNAi products in human, mouse, rat for CHEK2  
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     Block miRNA regulation of human, mouse, rat CHEK2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CHEK2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHEK2 Predesigned siRNA for gene silencing in human, mouse, rat CHEK2
     QuantiFast Probe-based Assays in human, mouse, rat CHEK2 QuantiTect SYBR Green Assays in human, mouse, rat CHEK2
     PCR Arrays including human, mouse, rat CHEK2 Search Chromatin IP Primers for CHEK2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHEK2  GeneGlobe Interaction Network for CHEK2
     Regulatory tfbs in CHEK2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CHEK2 GenScript cDNA clones with any tag delivered in your preferred vector for CHEK2
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Antibodies & Assays for CHEK2  (Chk2)

     Tocris compounds for CHEK2
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     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
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     Drugs/Proteins for CHEK2
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CHEK2 antibodies
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     See all of Abcam's Antibodies, Kits and Proteins for CHEK2
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CHEK2
     Antibodies for CHEK2
     ELISAs for CHEK2
     CLIAs for CHEK2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CHEK2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHEK2
     SwitchGear 3'UTR luciferase reporter plasmids for CHEK2
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     ThermoFisher Antibody for CHEK2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHEK2
     ApexBio compounds for CHEK2
     Addgene plasmids for CHEK2
      Search eBioscience for proteins for CHEK2
      Search eBioscience for elisas for CHEK2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for CHEK2
     antibodies-online antibodies for CHEK2 (340 products)
     antibodies-online kits for CHEK2 (7 products)
     antibodies-online peptides for CHEK2
     antibodies-online proteins for CHEK2 (6 products)
           
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