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Aliases for CHEK1 Gene

Aliases for CHEK1 Gene

  • Checkpoint Kinase 1 2 3
  • CHK1 3 4 6
  • Cell Cycle Checkpoint Kinase 3 4
  • CHK1 Checkpoint Homolog 3 4
  • Checkpoint Kinase-1 3 4
  • EC 2.7.11.1 4 63
  • Serine/Threonine-Protein Kinase Chk1 3
  • Checkpoint, S. Pombe, Homolog Of, 1 3
  • CHK1 (Checkpoint, S.Pombe) Homolog 2
  • CHK1 Checkpoint Homolog (S. Pombe) 2
  • EC 2.7.11 63
  • Chk1-S 3

External Ids for CHEK1 Gene

Previous GeneCards Identifiers for CHEK1 Gene

  • GC11P127497
  • GC11P127009
  • GC11P125529
  • GC11P125033
  • GC11P125001
  • GC11P125495
  • GC11P121436

Summaries for CHEK1 Gene

Entrez Gene Summary for CHEK1 Gene

  • The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CHEK1 Gene

CHEK1 (Checkpoint Kinase 1) is a Protein Coding gene. Diseases associated with CHEK1 include hypoxia. Among its related pathways are PI-3K cascade and Signaling by GPCR. GO annotations related to this gene include identical protein binding and histone kinase activity (H3-T11 specific).

UniProtKB/Swiss-Prot for CHEK1 Gene

  • Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at Ser-178 and Thr-507 and phosphorylation of CDC25C at Ser-216 creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 promotes proteolysis of CDC25A. Phosphorylation of CDC25A at Ser-76 primes the protein for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at Thr-309, which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at Ser-743, which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA. May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes. May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest

  • Isoform 2: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition

Tocris Summary for CHEK1 Gene

  • Checkpoint kinases (Chks) are serine/threonine kinases that are involved in the control of the cell cycle. Two subtypes have so far been identified, Chk1 and Chk2. They are essential components to delay cell cycle progression in normal and damaged cells and can act at all three cell cycle checkpoints. Chks are activated by phosphorylation. ATR kinase phosphorylates Chk1 in response to single strand DNA breaks and ATM kinase phosphorylates Chk2 in response to double strand breaks. Chks phosphorylate Cdc25 phosphatase at Ser216, which leads to Cdc25 sequestration in the cytoplasm. Therefore Cdc25 cannot remove the inhibitory phosphorylation on mitotic promoting factor (MPF) and entry into mitosis is prohibited. In addition, Chks have a role in the physiological stress of hypoxia/reoxygenation.

Gene Wiki entry for CHEK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHEK1 Gene

Genomics for CHEK1 Gene

Regulatory Elements for CHEK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHEK1 Gene

Start:
125,625,136 bp from pter
End:
125,676,255 bp from pter
Size:
51,120 bases
Orientation:
Plus strand

Genomic View for CHEK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHEK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHEK1 Gene

Proteins for CHEK1 Gene

  • Protein details for CHEK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14757-CHK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase Chk1
    Protein Accession:
    O14757
    Secondary Accessions:
    • A8K934
    • B4DDD0
    • B4DSK3
    • B5BTY6
    • F5H7S4
    • H2BI51

    Protein attributes for CHEK1 Gene

    Size:
    476 amino acids
    Molecular mass:
    54434 Da
    Quaternary structure:
    • Interacts (phosphorylated by ATR) with RAD51. Interacts with and phosphorylates CLSPN, an adapter protein that regulates the ATR-dependent phosphorylation of CHEK1. Interacts with BRCA1. Interacts with and phosphorylates CDC25A, CDC25B and CDC25C. Interacts with FBXO6, which regulates CHEK1. Interacts with PPM1D, which regulates CHEK1 through dephosphorylation. Interacts with TIMELESS; DNA damage-dependent. Interacts with FEM1B; activates CHEK1 in response to stress. Interacts with TLK1. Interacts with XPO1 and YWHAZ. Isoform 1 associates with isoform 2, the interaction is disrupted upon phosphorylation by ATR.

    Three dimensional structures from OCA and Proteopedia for CHEK1 Gene

    Alternative splice isoforms for CHEK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHEK1 Gene

Proteomics data for CHEK1 Gene at MOPED

Post-translational modifications for CHEK1 Gene

  • Phosphorylated by ATR in a RAD17-dependent manner in response to ultraviolet irradiation and inhibition of DNA replication. Phosphorylated by ATM in response to ionizing irradiation. ATM and ATR can both phosphorylate Ser-317 and Ser-345 and this results in enhanced kinase activity. Phosphorylation at Ser-345 induces a change in the conformation of the protein, activates the kinase activity and is a prerequisite for interaction with FBXO6 and subsequent ubiquitination at Lys-436. Phosphorylation at Ser-345 also increases binding to 14-3-3 proteins and promotes nuclear retention. Conversely, dephosphorylation at Ser-345 by PPM1D may contribute to exit from checkpoint mediated cell cycle arrest. Phosphorylation at Ser-280 by AKT1/PKB, may promote mono and/or diubiquitination. Also phosphorylated at undefined residues during mitotic arrest, resulting in decreased activity.
  • Ubiquitinated. Mono or diubiquitination promotes nuclear exclusion (By similarity). The activated form (phosphorylated on Ser-345) is polyubiquitinated at Lys-436 by some SCF-type E3 ubiquitin ligase complex containing FBXO6 promoting its degradation. Ubiquitination and degradation are required to terminate the checkpoint and ensure that activated CHEK1 does not accumulate as cells progress through S phase, when replication forks encounter transient impediments during normal DNA replication.
  • Ubiquitination at Lys180, Lys244, Lys313, and Lys436
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CHEK1 (Chk1)

Protein Products

Domains for CHEK1 Gene

Gene Families for CHEK1 Gene

Suggested Antigen Peptide Sequences for CHEK1 Gene

Graphical View of Domain Structure for InterPro Entry

O14757

UniProtKB/Swiss-Prot:

CHK1_HUMAN :
  • O14757
Domain:
  • The autoinhibitory region (AIR) inhibits the activity of the kinase domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.
genes like me logo Genes that share domains with CHEK1: view

Function for CHEK1 Gene

Molecular function for CHEK1 Gene

GENATLAS Biochemistry: checkpoint,S pombe homolog 1,component of the G2/M checkpoint,phosphorylating and inactivating CDC25C,required for cell cycle arrest in reponse to DNA damage,in association with 14.3.3 proteins (YWHA*),altered in colon and endometrial tumors
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated through phosphorylation predominantly by ATR but also by ATM in response to DNA damage or inhibition of DNA replication. Activation is modulated by several mediators including CLSPN, BRCA1 and FEM1B
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at Ser-178 and Thr-507 and phosphorylation of CDC25C at Ser-216 creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at Ser-76, Ser-124, Ser-178, Ser-279 and Ser-293 promotes proteolysis of CDC25A. Phosphorylation of CDC25A at Ser-76 primes the protein for subsequent phosphorylation at Ser-79, Ser-82 and Ser-88 by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CDC25 leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Also phosphorylates NEK6. Binds to and phosphorylates RAD51 at Thr-309, which promotes the release of RAD51 from BRCA2 and enhances the association of RAD51 with chromatin, thereby promoting DNA repair by homologous recombination. Phosphorylates multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and promotes cell cycle arrest and suppression of cellular proliferation. Also promotes repair of DNA cross-links through phosphorylation of FANCE. Binds to and phosphorylates TLK1 at Ser-743, which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may enhance chromatin assembly both in the presence or absence of DNA damage. May also play a role in replication fork maintenance through regulation of PCNA. May regulate the transcription of genes that regulate cell-cycle progression through the phosphorylation of histones. Phosphorylates histone H3.1 (to form H3T11ph), which leads to epigenetic inhibition of a subset of genes. May also phosphorylate RB1 to promote its interaction with the E2F family of transcription factors and subsequent cell cycle arrest
UniProtKB/Swiss-Prot Function: Isoform 2: Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition

Enzyme Numbers (IUBMB) for CHEK1 Gene

Gene Ontology (GO) - Molecular Function for CHEK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IMP 22024163
GO:0004674 protein serine/threonine kinase activity IDA 16963448
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 11836499
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CHEK1: view
genes like me logo Genes that share phenotypes with CHEK1: view

Animal Models for CHEK1 Gene

MGI Knock Outs for CHEK1:

Animal Model Products

CRISPR Products

No data available for Transcription Factor Targeting and HOMER Transcription for CHEK1 Gene

Localization for CHEK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHEK1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Nuclear export is mediated at least in part by XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHEK1 Gene COMPARTMENTS Subcellular localization image for CHEK1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CHEK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 colocalizes_with chromosome, telomeric region IDA 15149599
GO:0000785 chromatin ISS --
GO:0000794 condensed nuclear chromosome IDA 9382850
GO:0005615 extracellular space IDA 23580065
GO:0005634 nucleus IDA 15311285
genes like me logo Genes that share ontologies with CHEK1: view

Pathways for CHEK1 Gene

genes like me logo Genes that share pathways with CHEK1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CHEK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000077 DNA damage checkpoint IMP 19716789
GO:0000086 G2/M transition of mitotic cell cycle IEA --
GO:0006260 DNA replication TAS --
GO:0006281 DNA repair IMP 19716789
GO:0006468 protein phosphorylation --
genes like me logo Genes that share ontologies with CHEK1: view

Compounds for CHEK1 Gene

Compound Products

(5) Tocris Compounds for CHEK1 Gene

Compound Action Cas Number
AZD 7762 hydrochloride Potent and selective ATP-competitive inhibitor of Chk1 and Chk2 [1246094-78-9]
NSC 109555 ditosylate Selective Chk2 inhibitor [66748-43-4]
PF 477736 Selective Chk1 inhibitor [952021-60-2]
SB 218078 Inhibitor of checkpoint kinase 1 (Chk1) [135897-06-2]
TCS 2312 Potent Chk1 inhibitor [838823-31-7]

(5) ApexBio Compounds for CHEK1 Gene

Compound Action Cas Number
AZD7762 inhibitor of checkpoint kinases (Chks) [860352-01-8]
CCT241533 hydrochloride potent serine/threonine checkpoint kinase (Chk2) inhibitor. [1431697-96-9]
CHIR-124 potent inhibitor of Chk1 [405168-58-3]
LY2603618 highly selective Chk 1 inhibitor [911222-45-2]
MK-8776 (SCH-900776) potent and functionally selective inhibitor targeting Chk1. [891494-63-6]

(2) HMDB Compounds for CHEK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(56) Novoseek inferred chemical compound relationships for CHEK1 Gene

Compound -log(P) Hits PubMed IDs
isogranulatimide 88.9 9
7-hydroxystaurosporine 83.2 8
debromohymenialdisine 82.7 3
karenitecin 75.7 9
hydroxyurea 70.8 21
genes like me logo Genes that share compounds with CHEK1: view

Transcripts for CHEK1 Gene

Unigene Clusters for CHEK1 Gene

Checkpoint kinase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHEK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHEK1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^
SP1: -
SP2: -
SP3: - - - - - -
SP4:
SP5: - - - - - - -
SP6: - - - - -
SP7: -
SP8: -
SP9: - -
SP10: - -
SP11:

ExUns: 15 ^ 16
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for CHEK1 Gene

GeneLoc Exon Structure for
CHEK1
ECgene alternative splicing isoforms for
CHEK1

Expression for CHEK1 Gene

mRNA expression in normal human tissues for CHEK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHEK1 Gene

SOURCE GeneReport for Unigene cluster for CHEK1 Gene Hs.24529

mRNA Expression by UniProt/SwissProt for CHEK1 Gene

O14757-CHK1_HUMAN
Tissue specificity: Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon.
genes like me logo Genes that share expressions with CHEK1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CHEK1 Gene

Orthologs for CHEK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CHEK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHEK1 35
  • 99.72 (n)
  • 99.58 (a)
CHEK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHEK1 35
  • 92.51 (n)
  • 95.59 (a)
CHEK1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHEK1 35
  • 92.95 (n)
  • 96.92 (a)
CHEK1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chek1 35
  • 89.01 (n)
  • 93.07 (a)
Chek1 16
Chek1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHEK1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHEK1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chek1 35
  • 88.59 (n)
  • 94.12 (a)
chicken
(Gallus gallus)
Aves STT3A 35
  • 69.83 (n)
  • 84.6 (a)
STT3A 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHEK1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398191 35
tropical clawed frog
(Silurana tropicalis)
Amphibia chek1 35
  • 71.19 (n)
  • 78.18 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1073 35
zebrafish
(Danio rerio)
Actinopterygii chek1 35
  • 63.88 (n)
  • 65.27 (a)
chek1 36
  • 66 (a)
OneToOne
efnb1 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008118 35
  • 54.67 (n)
  • 54.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta grp 35
  • 53.82 (n)
  • 50.44 (a)
grp 36
  • 44 (a)
OneToOne
grp 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea chk-1 35
  • 47.8 (n)
  • 41.14 (a)
chk-1 36
  • 27 (a)
OneToMany
kin-33 36
  • 18 (a)
OneToMany
kin-34 36
  • 30 (a)
OneToMany
R02C2.1 36
  • 30 (a)
OneToMany
R02C2.6 36
  • 30 (a)
OneToMany
Y43D4A.6 36
  • 32 (a)
OneToMany
R02C2.1 37
  • 37 (a)
DC2.7a 37
  • 33 (a)
Y43D4A.6 37
  • 40 (a)
DC2.7b 37
  • 38 (a)
R02C2.2 37
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL185C 35
  • 44.76 (n)
  • 34.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHK1 35
  • 45.68 (n)
  • 34.37 (a)
CHK1 36
  • 20 (a)
OneToOne
CHK1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01276g 35
  • 44.84 (n)
  • 32.96 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08346 35
  • 47.47 (n)
  • 36.58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes chk1 35
  • 45.82 (n)
  • 33.89 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1196 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for CHEK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHEK1 Gene

ENSEMBL:
Gene Tree for CHEK1 (if available)
TreeFam:
Gene Tree for CHEK1 (if available)

Paralogs for CHEK1 Gene

genes like me logo Genes that share paralogs with CHEK1: view

No data available for Paralogs for CHEK1 Gene

Variants for CHEK1 Gene

Sequence variations from dbSNP and Humsavar for CHEK1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs471164 -- 125,650,315(-) gaaac(A/C)aagta intron-variant
rs471269 -- 125,650,281(-) caacc(A/C)aaact intron-variant
rs473526 -- 125,671,120(-) agacc(A/C)gcttg intron-variant
rs473613 -- 125,671,087(-) tctac(A/C)aaaag intron-variant
rs474360 -- 125,668,670(-) agact(A/G)aggca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHEK1 Gene

Variant ID Type Subtype PubMed ID
esv32964 CNV Gain+Loss 17666407

Relevant External Links for CHEK1 Gene

HapMap Linkage Disequilibrium report
CHEK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHEK1 Gene

Disorders for CHEK1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CHEK1 Gene including...

Search for CHEK1 Gene in MalaCards »

(4) University of Copenhagen DISEASES for CHEK1 Gene

(28) Novoseek inferred disease relationships for CHEK1 Gene

Disease -log(P) Hits PubMed IDs
ataxia telangiectasia 87.7 25
fanconis anemia 55.8 3
cancer 55.2 42
colon carcinoma 49.2 8
tumors 46.5 66

Relevant External Links for CHEK1

Genetic Association Database (GAD)
CHEK1
Human Genome Epidemiology (HuGE) Navigator
CHEK1
genes like me logo Genes that share disorders with CHEK1: view

No data available for UniProtKB/Swiss-Prot for CHEK1 Gene

Publications for CHEK1 Gene

  1. Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. (PMID: 9382850) Flaggs G. … Carr A.M. (Curr. Biol. 1997) 2 3 4 23
  2. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. (PMID: 11390642) Zhao H. … Piwnica-Worms H. (Mol. Cell. Biol. 2001) 3 4 23
  3. Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing. (PMID: 11535615) Feijoo C. … Smythe C. (J. Cell Biol. 2001) 3 4 23
  4. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. (PMID: 10859164) Liu Q. … Elledge S.J. (Genes Dev. 2000) 3 4 23
  5. Determination of substrate motifs for human Chk1 and hCds1/Chk2 by the oriented peptide library approach. (PMID: 11821419) O'Neill T. … Rathbun G.A. (J. Biol. Chem. 2002) 3 4 23

Products for CHEK1 Gene

  • Addgene plasmids for CHEK1

Sources for CHEK1 Gene

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