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CHEK1 Gene

protein-coding   GIFtS: 71

GC11P125001
CHK1 checkpoint homolog (S. pombe)
(Previous names: CHK1 (checkpoint, S.pombe) homolog )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for CHEK1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CHK1 1, 2, 3, 5
EC 2.7.11.1 3
Descriptions
CHK1 (checkpoint, S.pombe) homolog 1
CHK1 checkpoint homolog (S. pombe) 2
Checkpoint, S. pombe, homolog of, 1 2
checkpoint kinase 1 2
External Ids
HGNC: 19251
Entrez Gene: 11112
UniProtKB: O147573
Ensembl: ENSG000001495547
Search outside databases for aliases for CHEK1 gene

Previous GC identifers: GC11P127497 GC11P127009 GC11P125529 GC11P125033

Summaries
for CHEK1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CHK1_HUMAN, O14757
Function: Required for checkpoint mediated cell cycle arrest in response to DNA damage or the
presence of unreplicated DNA. May also negatively regulate cell cycle progression during
unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and
phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and
phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit
CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and
'Ser-293' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased
inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.
Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with
chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at
'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor
ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate
multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and
enhances suppression of cellular proliferation

Gene Wiki entry for CHEK1

Genomic Location
for CHEK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CHEK1 gene  

Entrez Gene cytogenetic band: 11q24-q24   Ensembl cytogenetic band:  11q24.2   HGNC cytogenetic band: 11q24.2

CHEK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P125001:     (about GC identifiers)

Start:
 125,001,547 bp from pter
End:
 125,030,847 bp from pter
Size:
 29,301 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000011.8  NT_033899.7  

Proteins
for CHEK1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: CHK1_HUMAN, O14757 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Chk1  
Size: 476 amino acids; 54420 Da
Subunit: Interacts with BRCA1, CLSPN, PPM1D, RAD51, TIMELESS, XPO1/CRM1 and YWHAZ/14-3-3 zeta
Subcellular location: Nucleus. Cytoplasm. Note=Nuclear export is mediated at least in part by
XPO1/CRM1. Also localizes to the centrosome specifically during interphase, where it may protect
centrosomal CDC2 kinase from inappropriate activation by cytoplasmic CDC25B
PDB structures from and Proteopedia :
1IA8 (3D)    1NVQ (3D)    1NVR (3D)    1NVS (3D)    1ZLT (3D)    1ZYS (3D)    2AYP (3D)    2BR1 (3D)    
2BRB (3D)    2BRG (3D)    2BRH (3D)    2BRM (3D)    2BRN (3D)    2BRO (3D)    2C3J (3D)    2C3K (3D)    
2C3L (3D)    2CGU (3D)    2CGV (3D)    2CGW (3D)    2CGX (3D)    2E9N (3D)    2E9O (3D)    2E9P (3D)    
2E9U (3D)    2E9V (3D)    2GDO (3D)    2GHG (3D)    2HOG (3D)    2HXL (3D)    2HXQ (3D)    2HY0 (3D)    
2QHM (3D)    2QHN (3D)    2R0U (3D)    2YWP (3D)    3F9N (3D)    

Post-translational modifications:

  • Phosphorylated by ATR in a RAD17-dependent manner in response to ultraviolet irradiation and
    inhibition of DNA replication. Phosphorylated by ATM in response to ionizing irradiation. ATM and
    ATR can both phosphorylate Ser-317 and Ser-345 and this results in enhanced kinase activity.
    Phosphorylation at Ser-345 also increases binding to 14-3-3 proteins and promotes nuclear
    retention. Conversely, dephosphorylation at Ser-345 by PPM1D may contribute to exit from
    checkpoint mediated cell cycle arrest. May also be phosphorylated at Ser-280 by AKT1/PKB, which
    may promote mono and/or diubiquitination. Also phosphorylated at undefined residues during mitotic
    arrest, which results in decreased activity1
  • Ubiquitinated. Mono or diubiquitination promotes nuclear exclusion (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001107593.1  NP_001107594.1  NP_001265.2  


    ENSEMBL proteins: 
    ENSP00000278916 


    Human Recombinant Proteins 
    Invitrogen human recombinant proteins for CHEK1
    Millipore Purified and/or Recombinant CHEK1 Protein
    Sigma-Aldrich Proteins for CHEK1  
    R&D Systems Recombinant & Natural Proteins for CHEK1 (Chk1)
    Enzo Life Sciences proteins for CHEK1
    Recombinant Proteins from Abcam (Chk1)
    Human Recombinant Proteins from Abnova (CHEK1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000794 condensed nuclear chromosome TAS9382850
    GO:0005634 nucleus IEA--
    GO:0005654 nucleoplasm EXP9278512 12399544
    GO:0005657 replication fork IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for CHEK1: 
    Invitrogen Antibodies for CHEK1
    Millipore Mono- and Polyclonal Antibodies for the study of CHEK1
    Sigma-Aldrich Antibody Arrays and Antibodies for CHEK1
    R&D Systems Antibodies for CHEK1 (Chk1)
    Cell Signaling Technology (CST) Antibodies for CHEK1  (Chk1)
    Antibodies from Abcam (Chk1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (CHEK1)
    Novus Biologicals Antibodies for CHEK1

    Assays for CHEK1: 
    Invitrogen Assays for CHEK1
    Millipore Kits and Assays for the Analysis of CHEK1
    Browse R&D Systems for biochemical assays
    Cell Signaling Technology (CST) Sandwich ELISA Kits for CHEK1 (Chk1)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for CHEK1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro domains/families (see all 6 ):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser_thr_pkinase
     IPR008271 Ser_thr_pkin_AS
     IPR000719 Prot_kinase_core
     IPR017442 Se/Thr_pkinase-rel


       GeneDecks  CHEK1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O14757

    ProtoNet protein and cluster: O14757

    UniProtKB/Swiss-Prot: CHK1_HUMAN, O14757
    Domain: The autoinhibitory region (AIR) inhibits the activity of the kinase domain
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1
    subfamily
    Similarity: Contains 1 protein kinase domain

    Gene Function
    for CHEK1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CHEK1)
    Millipore RNAi Products for the Analysis of CHEK1 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (CHEK1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001274

                  Applied Biosystems Silencer® siRNAs for CHEK1

                  Sigma-Aldrich siRNA and siRNA Panels for CHEK1  
                         Sigma-Aldrich shRNA Panels and shRNA for CHEK1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001114121
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001114121
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001114121 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001274

    UniProtKB/Swiss-Prot: CHK1_HUMAN, O14757
    Function: Required for checkpoint mediated cell cycle arrest in response to DNA damage or the
    presence of unreplicated DNA. May also negatively regulate cell cycle progression during
    unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and
    phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and
    phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit
    CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and
    'Ser-293' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased
    inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression.
    Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with
    chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at
    'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor
    ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate
    multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and
    enhances suppression of cellular proliferation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Genatlas biochemistry entry for CHEK1:
    checkpoint,S pombe homolog 1,component of the G2/M checkpoint,phosphorylating and inactivating
    CDC25C,required for cell cycle arrest in reponse to DNA damage,in association with 14.3.3 proteins
    (YWHA*),altered in colon and endometrial tumors

    6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Chek1):

    cellularembryogenesisendocrine/exocrine glandlethality-prenatal/perinatalreproductive system
    tumorigenesis

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0005515 protein binding IPI11836499 15798197 16330544 16963448 17157788 17292828
    GO:0005524 ATP binding IEA--
    GO:0016740 transferase activity IEA--
    About this table

    Pathways & Interactions
    for CHEK1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5 Invitrogen iPath™ Online BioAtlas - Pathways for CHEK1 (Maps provided by GeneGo):
     Cdc25 regulation of cell cycle
     S-phase DNA damage response
     ATM/ATR regulation of G1/S checkpoint
     DNA damage response in inhibition of CDK1 during G2
     ATM/ATR regulation of G2/M checkpoint

       GeneDecks  CHEK1 for the pathways selected above  
    About GeneDecksing

    4 Millipore Pathways for CHEK1
     DNA damage ATM/ATR regulation of G1/S checkpoint
     Cell cycle Role of 14-3-3 proteins in cell cycle regulation
     DNA damage DNA-damage-induced responses
     Cell cycle Role of SCF complex in cell cycle regulation

       GeneDecks  CHEK1 for the pathways selected above  
    About GeneDecksing

    5/7 Sigma-Aldrich "Your Favorite Gene" Pathways for  CHEK1  (Your Favorite Gene powered by Ingenuity) (see all 7 ) 
     Role of CHK Proteins in Cell Cycle Checkpoint Control
     Molecular Mechanisms of Cancer
     Cell Cycle: G2/M DNA Damage Checkpoint Regulation
     p53 Signaling
     ATM Signaling

       GeneDecks  CHEK1 for the pathways selected above  
    About GeneDecksing

    2 Cell Signaling Technology (CST) Pathways for CHEK1: 
     Cell Cycle Control: G2/M DNA Damage Checkpoint
     Akt/PKB Signaling

       GeneDecks  CHEK1 for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for CHEK1):
     hsa04110 Cell cycle
     hsa04115 p53 signaling pathway

       GeneDecks  CHEK1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  CHEK1 


    5/102 Interacting proteins for CHEK1 (O147571, 2 ENSP000002789163) via UniProtKB, MINT, and/or STRING (see all 102 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RB1P064002, ENSP000002671633MINT-4793782 MINT-4793761 MINT-4793746 STRING (score=.811)
    CDC25AP303041, ENSP000003037063EBI-974488, EBI-747671 STRING (score=.999)
    CDC25CP303071, ENSP000003216563EBI-974488, EBI-974439 STRING (score=.999)
    CLSPNQ9HAW41, ENSP000003623173EBI-974488, EBI-1369377 STRING (score=.999)
    TP53P046372, ENSP000002693053MINT-1958329 STRING (score=.999)
    About this table

    5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000077 DNA damage checkpoint TAS9278511
    GO:0000079 regulation of cyclin-dependent protein kinase activity TAS9278511
    GO:0000086 G2/M transition of mitotic cell cycle IEA--
    GO:0006260 DNA replication EXP12791985
    GO:0006281 DNA repair IEA--
    About this table

    Drugs & Compounds
    for CHEK1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Compounds for CHEK1 available from Tocris Bioscience
    CompoundAction CAS number
    SB 218078Inhibitor of checkpoint kinase 1 (Chk1)[135897-06-2]
    TCS 2312 dihydrochloridePotent Chk1 inhibitor[838823-32-8]
    PD 407824Selective inhibitor of Chk1 and Wee1[622864-54-4]
    About this table


    10/24 Novoseek chemical compound relationships for CHEK1 gene (see all 24 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    isogranulatimide 87.90 9 15486189 (4), 17134696 (3), 17582773 (1)
    debromohymenialdisine 84.64 4 15078995 (1), 19177354 (1), 16289938 (1)
    karenitecin 76.85 14 11536038 (4), 12150968 (3), 10692484 (2)
    rpa 2 67.14 4 15197179 (1), 11731442 (1), 18289945 (1)
    17-(allylamino)-17-demethoxygeldanamycin 64.84 17 15784732 (3), 14570880 (3), 18820127 (2), 15699047 (1) (see all 6)
    bpde 61.77 16 11864911 (5), 17630511 (3), 16912045 (2), 19139065 (1) (see all 5)
    threonine 44.84 14 18694366 (1), 15539958 (1), 17517898 (1), 15951851 (1) (see all 13)
    mnng 41.91 4 15647386 (3), 15994368 (1)
    wortmannin 30.22 4 12959929 (1), 11912127 (1), 14751515 (1), 15533933 (1)
    indole 19.78 1 17722905 (1)
    About this table


    Transcripts
    for CHEK1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (CHEK1)
    Millipore RNAi Products for the Analysis of CHEK1 Gene knock-down
    Abnova Chimera RNAi Products for Gene knock-down (CHEK1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001274

                  Sigma-Aldrich siRNA and siRNA Panels for CHEK1  
                         Sigma-Aldrich shRNA Panels and shRNA for CHEK1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001114121  NM_001114122  NM_001274  

    REFSEQ mRNAs for CHEK1 gene (3 alternative transcripts): 

    NM_001114121.1   NM_001114122.1   NM_001274.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001114121  NM_001114122  NM_001274  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001114121
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001114121
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001114121 

    Additional cDNA sequence: 

    AB451222.1 AB451345.1 AF016582.1 AF032874.1 AK292549.1 AK293143.1 AK299783.1 AK300082.1 
    BC004202.2 BC017575.1 CR591943.1 CR597063.1 CR609507.1 CR612881.1 

    14 DOTS entries:

    DT.97767236  DT.92430103  DT.100787847  DT.95072818  DT.120738698  DT.99943016  DT.100784077  DT.40265649 
    DT.100784075  DT.100787845  DT.91905269  DT.120738635  DT.120738562  DT.97858582 

    24/143 AceView cDNA sequences (see all 143 ):

    AF016582 BP368064 R06653 CR609507 CR591943 BQ919396 BQ424951 BM458297 
    BX425856 AF032874 CR597063 CR612881 BX352948 BX345096 BM478961 AA281116 
    AI081591 AL515222 BX383978 N99369 BQ071454 AA513363 CA441277 AA352836 

    highest scoring ESTs for CHEK1:

    AF016582 AA513363 AA962684 AI280123 BG211479 BG216281 BG218896 H67490 AF032874 BC004202 

    Unigene Cluster for CHEK1:

    CHK1 checkpoint homolog (S. pombe)
    Hs.24529  [show with all ESTs]
    Unigene Representative Sequence: NM_001114122


    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for CHEK1 (see all 11 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^
    SP1:                                                  -                                                                                                         
    SP2:                                                                    -                                                                                       
    SP3:                    -     -     -     -     -     -                                                                                                         
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -     -                 -                                                                                       

    ExUns: 15 ^ 16
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            

    About this scheme

    ECgene alternative splicing isoforms for CHEK1

    1 Ensembl transcript including schematic representation:
    ENST00000278916  

    Expression
    for CHEK1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CHEK1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CHEK1

    1 / 2 / 3

    5 probe-sets matching CHEK1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		38920_at2, 3 U95-A 1 0.50 1.00 1.00 1.00 AF016582 1.00 0.90 0.95 1

    		205394_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001274 0.60 1.00 0.82 1

    		205393_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_001274 0.60 1.00 0.82 1

    		205394_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		205393_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTGATTTAAT

    SOURCE GeneReport for Unigene cluster: Hs.24529

    Expression variation in blood from EXPOLDB for CHEK1

    UniProtKB/Swiss-Prot: CHK1_HUMAN, O14757
    Tissue specificity: Expressed ubiquitously with the most abundant expression in thymus, testis,
    small intestine and colon

    Orthologs
    for CHEK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for CHEK1 gene from 5/18 species (see all 18 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 CHEK11   -- CHK1 checkpoint homolog (S. pombe) 93.02(n)
    97.14(a)    		 609767  XM_847098.1  XP_852191.1 
    chimpanzee
    (Pan troglodytes)    		 CHEK11   -- CHK1 checkpoint homolog (S. pombe) 99.79(n)
    99.79(a)    		 739836  XM_001145968.1  XP_001145968.1 
    cow
    (Bos taurus)    		 CHEK11   -- CHK1 checkpoint homolog (S. pombe) 92.58(n)
    95.8(a)    		 513678  XM_591405.3  XP_591405.2 
    rat
    (Rattus norvegicus)    		 Chek11   -- CHK1 checkpoint homolog (S. pombe) 88.66(n)
    94.33(a)    		 140583  NM_080400.1  NP_536325.1 
    mouse
    (Mus musculus)    		 Chek11, 5 95
    		 checkpoint kinase 1 homolog (S. pombe)1, 5 89.08(n)1
    93.28(a)1    		 126491  NM_007691.31  NP_031717.21 
     AF0165835  AF0328755  (see all 17)
    About this table        Species with no ortholog for CHEK1

    ENSEMBL Gene Tree for CHEK1

    Paralogs
    for CHEK1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CHEK1 gene
    SBK22  SBK12  HUNK2  

    SNPs/Variants
    for CHEK1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/239 NCBI SNPs in CHEK1 are shown (see all 239 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 112)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs37313941,2
    		A,C,F,H125001488(+) CCCATA/TCCGCT 1 -- ng518Minor allele frequency- T:0.11NS EU EA WA NA 712
    rs5583511,2
    		A,C,F,H125000474(-) AGTGTG/ATGTGG 3 -- ng51 ut5116Minor allele frequency- A:0.43EA NA MN EU WA 3686
    rs5065041,2
    		A,C,F,H125030405(-) CCAAAC/TCTTCT 3 I/V mis1 ese321Minor allele frequency- T:0.02MN CSAM EA NA EU WA 1852
    rs37313951,2
    		A,C,F,H125001609(+) CTCTGG/AGGCCT 1 -- ut51 ese314Minor allele frequency- A:0.13NS EU EA WA NA 1382
    rs5557521,2
    		C,F,H125000731(-) CGCTTC/ACAGGC 3 -- ng51 ut517Minor allele frequency- A:0.17NA EU EA WA 560
    rs22984831,2
    		C,F,H125000232(-) CGTACG/ATCATT 1 -- ng5112Minor allele frequency- A:0.16EA NA EU WA 2284
    --
    rs37314801,2
    		C,F125030800(+) ATATT-/TCTT  
                CCATG     		2 -- ut311Minor allele frequency- TCTT:0.34NS 174
    rs358174041,2
    		C125010588(+) GAAAGA/TAAAAA 3 E/V mis14Minor allele frequency- T:0.00EU EA WA 418
    --
    rs112201681,2
    		A124999651(+) acacgC/Tgtgag 1 -- ng510--------
    --
    rs92826581,2
    		F125030486(+) ATTCTT/GCCTAG 2 -- ut31 ese35Minor allele frequency- G:0.01MN CSAM EA 408
    About this table

    HapMap Linkage Disequilibrium images for CHEK1 (up to first 250kb)

    Disorders & Mutations
    for CHEK1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 603078

    10/27 Novoseek disease relationships for CHEK1 gene (see all 27 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    ataxia telangiectasia 87.85 28 17297454 (2), 11572854 (1), 17644383 (1), 18066095 (1) (see all 24)
    cancer 51.60 45 16842237 (3), 15608676 (3), 17019715 (2), 18642443 (2) (see all 22)
    fanconis anemia 49.64 2 18029388 (1), 18424430 (1)
    tumors 43.20 77 14570880 (3), 18159231 (3), 16927022 (3), 17019715 (2) (see all 44)
    colon carcinoma 42.29 7 15326376 (1), 17722905 (1), 18593931 (1), 17582773 (1) (see all 7)
    leukemia l1210 39.66 4 17722905 (1), 17582773 (1), 17502122 (1), 16996169 (1)
    lymphoid neoplasm 36.64 2 15526025 (2)
    colon cancer 34.36 13 18671143 (1), 18566216 (1), 18679694 (1), 18159231 (1) (see all 6)
    glioblastoma 24.15 3 16099423 (2), 15930307 (1)
    osteosarcoma 19.76 2 15705874 (1), 17260016 (1)
    About this table

    Human Genome Epidemiology Navigator: CHEK1 (10 documents)

    Medical News
    for CHEK1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for CHEK1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/485 PubMed articles for CHEK1 gene (see all 485 ):

    Search for CHEK1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CHEK1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 1111 HGNC: 1925 AceView: CHEK1 Ensembl:ENSG00000149554 euGenes: HUgn1111
    ECgene: CHEK1 H-InvDB: CHEK1

    Other Databases showing CHEK1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing CHEK1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for CHEK1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/chek1/

    Licensable Technologies
    for CHEK1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for CHEK1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CHEK1:
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    		  Free SNP selection tool



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     Tocris compounds for CHEK1




     Proteins for CHEK1
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for CHEK1

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