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CHDH Gene

protein-coding   GIFtS: 60
GCID: GC03M053850

Choline Dehydrogenase

  Search for CHDH
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Choline Dehydrogenase1 2     Choline Dehydrogenase, Mitochondrial2
CDH2 3     CHDH45
CHD2 3     MIA405
EC 1.1.99.13 8     

External Ids:    HGNC: 242881   Entrez Gene: 553492   Ensembl: ENSG000000163917   OMIM: 6110775   UniProtKB: Q8NE623   

Export aliases for CHDH gene to outside databases

Previous GC identifers: GC03M053019 GC03M053706 GC03M053808 GC03M053826


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHDH Gene:
The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in
this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this
gene, but the full-length nature of only one has been characterized to date. (provided by RefSeq, Dec 2010)

GeneCards Summary for CHDH Gene:
CHDH (choline dehydrogenase) is a protein-coding gene. GO annotations related to this gene include flavin adenine dinucleotide binding and choline dehydrogenase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHDH gene promoter:
         Tal-1beta   ITF-2   NF-kappaB   NF-kappaB1   GATA-2   YY1   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHDH promoter sequence
   Search Chromatin IP Primers for CHDH

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHDH


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21

CHDH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHDH gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M053850:  view genomic region     (about GC identifiers)

Start:
53,846,362 bp from pter      End:
53,880,420 bp from pter
Size:
34,059 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CHDH_HUMAN, Q8NE62 (See protein sequence)
Recommended Name: Choline dehydrogenase, mitochondrial precursor  
Size: 594 amino acids; 65358 Da
Cofactor: FAD (By similarity)
Secondary accessions: Q9NY17

Explore the universe of human proteins at neXtProt for CHDH: NX_Q8NE62

Explore proteomics data for CHDH at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CHDH (Q8NE62) (see all 6)
     VLLLEAG  VDASIMP  VYVRGHA  NLQDHLE 


    See CHDH Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060867.2  
    ENSEMBL proteins: 
     ENSP00000319851   ENSP00000418273   ENSP00000419863  

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    Cloud-Clone Corp. Proteins for CHDH

     
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    Search eBioscience for ELISAs for CHDH 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012132 GMC_OxRdtase
     IPR007867 GMC_OxRtase_C
     IPR000172 GMC_OxRdtase_N

    Graphical View of Domain Structure for InterPro Entry Q8NE62

    ProtoNet protein and cluster: Q8NE62

    1 Blocks protein domain: IPB000172 Glucose-methanol-choline oxidoreductase

    UniProtKB/Swiss-Prot: CHDH_HUMAN, Q8NE62
    Similarity: Belongs to the GMC oxidoreductase family


    Find genes that share domains with CHDH           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHDH_HUMAN, Q8NE62
    Catalytic activity: Choline + acceptor = betaine aldehyde + reduced acceptor

         Enzyme Number (IUBMB): EC 1.1.99.11 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008812choline dehydrogenase activity IEA--
    GO:0016614oxidoreductase activity, acting on CH-OH group of donors ----
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
    GO:0050660flavin adenine dinucleotide binding IEA--
         
    Find genes that share ontologies with CHDH           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CHDH:
     Decreased homologous recombina  Increased G1 DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chdh):
     cellular  reproductive system 

    Find genes that share phenotypes with CHDH           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chdhtm1Zei for CHDH

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHDH
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHDH

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHDH
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHDH

    miRNA
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    miRTarBase miRNAs that target CHDH:
    hsa-mir-193b-3p (MIRT016262), hsa-mir-192-5p (MIRT026237)

    Block miRNA regulation of human, mouse, rat CHDH using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CHDH:
    hsa-miR-1276 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHDH 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CHDH

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHDH


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHDH_HUMAN, Q8NE62: Mitochondrion inner membrane (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--

    Find genes that share ontologies with CHDH           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHDH About    
    See pathways by source

    SuperPathContained pathways About
    1Glycine, serine and threonine metabolism
    choline degradation I0.00
    Glycine, serine and threonine metabolism
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with CHDH           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CHDH
        choline degradation I


    2 Kegg Pathways  (Kegg details for CHDH):
        Glycine, serine and threonine metabolism
    Metabolic pathways

    UniProtKB/Swiss-Prot: CHDH_HUMAN, Q8NE62
    Pathway: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline
    (cytochrome c reductase route): step 1/1

        Pathway & Disease-focused RT2 Profiler PCR Array including CHDH: 

              Amino Acid Metabolism II in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CHDH

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHDH (Q8NE622, 3 ENSP000003198514) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL8P629172, 3, ENSP000002625844MINT-8252516 I2D: score=2 STRING: ENSP00000262584
    SEZ6Q53EL92, 3, ENSP000003534404MINT-8252527 I2D: score=2 STRING: ENSP00000353440
    SDR39U1Q9NRG73, ENSP000003823274I2D: score=1 STRING: ENSP00000382327
    MDFIQ997503I2D: score=1 
    ALDH7A1ENSP000003871234STRING: ENSP00000387123
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006066alcohol metabolic process ----
    GO:0016117carotenoid biosynthetic process ----
    GO:0019285glycine betaine biosynthetic process from choline IEA--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with CHDH           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHDH

    9 HMDB Compounds for CHDH    About this table
    CompoundSynonyms CAS #PubMed Ids
    Betaine(Carboxymethyl)trimethylammonium hydroxide inner salt (see all 31)107-43-7--
    Betaine aldehyde(Formylmethyl)trimethylammonium (see all 8)7418-61-3--
    Choline(2-Hydroxyethyl)trimethyl ammonium (see all 19)62-49-7--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--
    N1-AcetylspermineN'-Acetylspermine (see all 6)25593-72-0--
    NorspermidineN-(3-aminopropyl)-1,3-Propanediamine (see all 28)56-18-8--
    Putrescine1,4-Butanediamine (see all 8)110-60-1--
    Spermidine1,5,10-Triazadecane (see all 15)124-20-9--
    Spermine1,5,10,14-Tetraazatetradecane (see all 18)71-44-3--

    1 DrugBank Compound for CHDH    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CholineBilineurine (see all 7)62-49-7enzymesubstrate17629908 17147620 17375117 16920841 16816108

    3 Novoseek inferred chemical compound relationships for CHDH gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    betaine aldehyde 90.6 2 8160802 (1), 10505788 (1)
    betaine 72.7 3 10653964 (2), 8160802 (1)
    choline 72.6 15 15302401 (2), 10653964 (2), 16816108 (1), 20031640 (1) (see all 7)



    Find genes that share compounds with CHDH           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHDH gene: 
    NM_018397.4  

    Unigene Cluster for CHDH:

    Choline dehydrogenase
    Hs.126688  [show with all ESTs]
    Unigene Representative Sequence: NM_018397
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315251(uc003dgz.3) ENST00000481668 ENST00000467802
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CHDH:
    hsa-miR-1276 hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCHDH 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat CHDH

    Additional mRNA sequence: 

    AJ272267.1 AK055402.1 AK297575.1 BC034502.1 

    4 DOTS entries:

    DT.207016  DT.209376  DT.95270119  DT.95270117 

    Selected AceView cDNA sequences (see all 127):

    AI733810 BG060119 C20981 AA582580 BF197431 AI241086 AA134288 BM052814 
    AK055402 AW469152 CB147231 AI792632 BM769931 BM142449 AI285166 BE464406 
    BF430927 BI765156 AI564145 BF435866 AI650346 AI631914 AA302739 BV205595 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CHDH    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8 ^ 9
    SP1:                                                                    -               
    SP2:                                -                                                   
    SP3:                                                                                    


    ECgene alternative splicing isoforms for CHDH

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHDH expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHDH Expression
    About this image


    CHDH expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Gonad
             Primordial Germ Cells Allantois
             Primordial germ cell-like cells
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    CHDH Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHDH Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.126688
        Pathway & Disease-focused RT2 Profiler PCR Array including CHDH: 
              Amino Acid Metabolism II in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHDH

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHDH gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chdh1 , 5 choline dehydrogenase1, 5 83.14(n)1
    83.93(a)1
      14 (18.40 cM)5
    2188651  NM_001136240.11  NP_001129712.11 
     300090235 
    chicken
    (Gallus gallus)
    Aves CHDH1 choline dehydrogenase 67.35(n)
    77.57(a)
      415993  XM_004944570.1  XP_004944627.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHDH6
    choline dehydrogenase
    70(a)
    1 ↔ 1
    2(160504753-160531282)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.319692 Xenopus laevis transcribed sequence 78.87(n)    CF547537.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chdh1 choline dehydrogenase 70.39(n)
    74.29(a)
      100331020  XM_002663255.2  XP_002663301.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG95213 choline dehydrogenase 41(a)
    (best of 14)
      12F6   --
    worm
    (Caenorhabditis elegans)
    Secernentea C34C6.41 , 3 choline dehydrogenase3
    C34C6.41
    55(a)3
    52.98(n)1
    57.82(a)1
      II(8696551-8698849)3
    1743901  NM_063445.51  NP_495846.11 


    ENSEMBL Gene Tree for CHDH (if available)
    TreeFam Gene Tree for CHDH (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHDH (see all 741)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829418981,2
    --53782436(+) AGCCCC/TGAGAC 1 -- ds50010--------
    rs1878558481,2
    --53782518(+) TGGCCA/GGTTTA 1 -- ds50010--------
    rs111303811,2
    C,F,A,H--53782531(+) ATTTTC/TTTTCT 1 -- ds500113Minor allele frequency- T:0.48NS EA NA CSA WA 772
    rs1915670301,2
    --53782549(+) CTCTTC/TGAACA 1 -- ds50010--------
    rs1396206721,2
    C--53782550(+) TCTTC-/GAACAA 1 -- ds50010--------
    rs1833508481,2
    --53782550(+) TCTTCA/GAACAA 1 -- ds50010--------
    rs1875380031,2
    C--53782623(+) GTGATG/TGGTTT 1 -- ds50010--------
    rs1921242291,2
    C--53782650(+) TCGAAC/GGTTTT 1 -- ds50010--------
    rs2008564061,2
    --53782683(+) TGTCG-/GACGCCCC 1 -- ds50010--------
    rs2020310621,2
    --53782684(+) GTCGG-/ACGCCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CHDH (53846362 - 53880420 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CHDH:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876803CNV Loss21882294
    nsv876805CNV Loss21882294
    dgv283n21CNV Loss19592680
    nsv876804CNV Gain21882294

    Human Gene Mutation Database (HGMD): CHDH
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHDH
    DNA2.0 Custom Variant and Variant Library Synthesis for CHDH

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611077    OMIM disorders: --


    Find genes that share disorders with CHDH           About GenesLikeMe

    Genetic Association Database (GAD): CHDH
    Human Genome Epidemiology (HuGE) Navigator: CHDH (9 documents)

    Export disorders for CHDH gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHDH gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with CHDH)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common genetic polymorphisms affect the human requirement for the nutrient choline. (PubMed id 16816108)1, 4, 7, 9 da Costa K.A....Zeisel S.H. (FASEB J. 2006)
    2. Associations of folate and choline metabolism gene polymorphisms with orofacial clefts. (PubMed id 19737740)1, 4 Mostowska A....Jagodzinski P.P. (J. Med. Genet. 2010)
    3. Polymorphisms located in the region containing BHMT and BHMT2 genes as maternal protective factors for orofacial clefts. (PubMed id 20662904)1, 4 Mostowska A....Jagodzinski P.P. (Eur. J. Oral Sci. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Choline metabolism and risk of breast cancer in a population-based study. (PubMed id 18230680)1, 4 Xu X....Chen J. (FASEB J. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cystathionine beta-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population. (PubMed id 20175737)1, 9 Kumar J....Sengupta S. (Biomarkers 2010)
    8. Single nucleotide polymorphisms in homocysteine metabolism pathway genes: association of CHDH A119C and MTHFR C677T with hyperhomocysteinemia. (PubMed id 20031640)1, 9 Kumar J....Sengupta S. (Circ Cardiovasc Genet 2009)
    9. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PubMed id 24144296)1 Cheng C.Y....Baird P.N. (Am. J. Hum. Genet. 2013)
    10. Phosphatidylethanolamine N-methyltransferase and choline dehydrogenase gene polymorphisms are associated with human sperm concentration. (PubMed id 22387881)1 Lazaros L....Georgiou I. (Asian J. Androl. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55349 HGNC: 24288 AceView: CHDH Ensembl:ENSG00000016391 euGenes: HUgn55349
    ECgene: CHDH Kegg: 55349 H-InvDB: CHDH

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHDH Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHDH gene:
    Search GeneIP for patents involving CHDH

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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