Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHD9 Gene

Aliases for CHD9 Gene

  • Chromodomain Helicase DNA Binding Protein 9 2 3
  • Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 320 KDa Protein 3 4
  • PPAR-Alpha-Interacting Complex Protein 320 KDa 3 4
  • Chromatin-Related Mesenchymal Modulator 3 4
  • Chromatin-Remodeling Factor CHROM1 3 4
  • ATP-Dependent Helicase CHD9 3 4
  • Kismet Homolog 2 3 4
  • PRIC320 3 4
  • CHD-9 3 4
  • CReMM 3 4
  • KISH2 3 4
  • Chromodomain-Helicase-DNA-Binding Protein 9 3
  • PPAR{Gamma}-Interacting Cofactor 320 KDa 3
  • Chromatin Remodeling Factor CHROM1 3
  • Ciprofibrate Bound Protein P240 3
  • Proteinx0008 3
  • EC 3.6.4.12 4
  • KIAA0308 4
  • EC 3.6.1 63
  • AD013 3

External Ids for CHD9 Gene

Previous GeneCards Identifiers for CHD9 Gene

  • GC16P051646
  • GC16P051747
  • GC16P038976

Summaries for CHD9 Gene

GeneCards Summary for CHD9 Gene

CHD9 (Chromodomain Helicase DNA Binding Protein 9) is a Protein Coding gene. Among its related pathways are L1CAM interactions and Metabolism. GO annotations related to this gene include helicase activity. An important paralog of this gene is CHD1.

UniProtKB/Swiss-Prot for CHD9 Gene

  • Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).

Gene Wiki entry for CHD9 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD9 Gene

Genomics for CHD9 Gene

Regulatory Elements for CHD9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHD9 Gene

Start:
53,054,993 bp from pter
End:
53,329,150 bp from pter
Size:
274,158 bases
Orientation:
Plus strand

Genomic View for CHD9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHD9 Gene

Proteins for CHD9 Gene

  • Protein details for CHD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3L8U1-CHD9_HUMAN
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 9
    Protein Accession:
    Q3L8U1
    Secondary Accessions:
    • B2RTU2
    • B9ZVQ0
    • O15025
    • Q1WF12
    • Q6DTK9
    • Q9H9V7
    • Q9UHM2

    Protein attributes for CHD9 Gene

    Size:
    2897 amino acids
    Molecular mass:
    326022 Da
    Quaternary structure:
    • Interacts with PPARA. Probably interacts with ESR1 and NR1I3.
    SequenceCaution:
    • Sequence=AAF24170.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAB14112.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CHD9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHD9 Gene

Proteomics data for CHD9 Gene at MOPED

Post-translational modifications for CHD9 Gene

Domains for CHD9 Gene

Graphical View of Domain Structure for InterPro Entry

Q3L8U1

UniProtKB/Swiss-Prot:

CHD9_HUMAN :
  • Q3L8U1
Domain:
  • Contains 2 chromo domains.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with CHD9: view

No data available for Gene Families for CHD9 Gene

Function for CHD9 Gene

Molecular function for CHD9 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA. Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis (By similarity).

Enzyme Numbers (IUBMB) for CHD9 Gene

Gene Ontology (GO) - Molecular Function for CHD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 16554032
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with CHD9: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHD9

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHD9 Gene

Localization for CHD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHD9 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHD9 Gene COMPARTMENTS Subcellular localization image for CHD9 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for CHD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CHD9: view

Pathways for CHD9 Gene

genes like me logo Genes that share pathways with CHD9: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CHD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
GO:0044255 cellular lipid metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with CHD9: view

Transcripts for CHD9 Gene

Unigene Clusters for CHD9 Gene

Chromodomain helicase DNA binding protein 9:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHD9

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CHD9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHD9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1:
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9: - - -
SP10: - -

ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37
SP1: - - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for CHD9 Gene

GeneLoc Exon Structure for
CHD9
ECgene alternative splicing isoforms for
CHD9

Expression for CHD9 Gene

mRNA expression in normal human tissues for CHD9 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHD9 Gene

SOURCE GeneReport for Unigene cluster for CHD9 Gene Hs.59159

mRNA Expression by UniProt/SwissProt for CHD9 Gene

Q3L8U1-CHD9_HUMAN
Tissue specificity: Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor cells adjacent to mature osteoblasts.
genes like me logo Genes that share expressions with CHD9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHD9 Gene

Orthologs for CHD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHD9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHD9 35
  • 99.6 (n)
  • 99.76 (a)
CHD9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHD9 35
  • 93.17 (n)
  • 95.52 (a)
CHD9 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHD9 35
  • 93.43 (n)
  • 96.01 (a)
CHD9 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chd9 35
  • 87.14 (n)
  • 91.07 (a)
Chd9 16
Chd9 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CHD9 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chd9 35
  • 82.95 (n)
  • 85.21 (a)
chicken
(Gallus gallus)
Aves CHD9 35
  • 80.84 (n)
  • 85.94 (a)
CHD9 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHD9 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii chd9 35
  • 62.22 (n)
  • 66.59 (a)
chd9 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta kis 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea chd-7 36
  • 27 (a)
OneToMany
Species with no ortholog for CHD9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CHD9 Gene

ENSEMBL:
Gene Tree for CHD9 (if available)
TreeFam:
Gene Tree for CHD9 (if available)

Paralogs for CHD9 Gene

Paralogs for CHD9 Gene

genes like me logo Genes that share paralogs with CHD9: view

Variants for CHD9 Gene

Sequence variations from dbSNP and Humsavar for CHD9 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs42312 -- 53,063,721(+) agaga(C/T)ggggt intron-variant
rs42363 -- 53,063,735(+) accat(G/T)ttagc intron-variant
rs1072684 -- 53,163,196(-) GTATA(C/T)GGGAA intron-variant
rs1073454 -- 53,162,130(-) ACACA(C/T)AGTTT intron-variant
rs1080313 -- 53,140,954(-) CTGCA(C/G)ATAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHD9 Gene

Variant ID Type Subtype PubMed ID
nsv833232 CNV Loss 17160897
nsv833233 CNV Gain 17160897
nsv510419 CNV Loss 20534489
nsv906665 CNV Loss 21882294
esv21460 CNV Loss 19812545
esv1370771 CNV Insertion 17803354
nsv906666 CNV Loss 21882294
esv2671644 CNV Deletion 23128226
nsv483048 CNV Gain 15286789
nsv9443 CNV Loss 18304495
nsv827652 CNV Loss 20364138

Relevant External Links for CHD9 Gene

HapMap Linkage Disequilibrium report
CHD9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD9 Gene

Disorders for CHD9 Gene

Relevant External Links for CHD9

Genetic Association Database (GAD)
CHD9
Human Genome Epidemiology (HuGE) Navigator
CHD9
genes like me logo Genes that share disorders with CHD9: view

No data available for UniProtKB/Swiss-Prot for CHD9 Gene

Publications for CHD9 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein. (PMID: 16095617) Shur I. … Benayahu D. (J. Mol. Biol. 2005) 3 4
  5. PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex. (PMID: 16554032) Surapureddi S. … Reddy J.K. (Biochem. Biophys. Res. Commun. 2006) 3 4

Products for CHD9 Gene

Sources for CHD9 Gene

Back to Top

Content