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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHD9 Gene

protein-coding   GIFtS: 56
GCID: GC16P053041

Chromodomain Helicase DNA Binding Protein 9

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromodomain Helicase DNA Binding Protein 91 2     PPAR-Alpha-Interacting Complex Protein 320 KDa2 3
Chromatin-Related Mesenchymal Modulator2 3     AD0132
Chromatin-Remodeling Factor CHROM12 3     Chromatin Remodeling Factor CHROM12
Kismet Homolog 22 3     Chromodomain-Helicase-DNA-Binding Protein 92
Peroxisomal Proliferator-Activated Receptor A-Interacting Complex 320 KDa
Protein2 3
     Ciprofibrate Bound Protein P2402
CHD-92 3     PPAR{Gamma}-Interacting Cofactor 320 KDa2
CReMM2 3     proteinx00082
KISH22 3     EC 3.6.4.123
PRIC3202 3     KIAA03083
ATP-Dependent Helicase CHD92 3     EC 3.6.18

External Ids:    HGNC: 257011   Entrez Gene: 802052   Ensembl: ENSG000001772007   UniProtKB: Q3L8U13   

Export aliases for CHD9 gene to outside databases

Previous GC identifers: GC16P051646 GC16P051747 GC16P038976


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CHD9 Gene: 
CHD9 (chromodomain helicase DNA binding protein 9) is a protein-coding gene. Diseases associated with CHD9 include gamma chain deficiency, and among its related super-pathways are Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) and Metabolic pathways. GO annotations related to this gene include helicase activity and ATP binding. An important paralog of this gene is CHD6.

UniProtKB/Swiss-Prot: CHD9_HUMAN, Q3L8U1
Function: Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a
ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA.
Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of
progenitors during osteogenesis (By similarity)

Gene Wiki entry for CHD9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHD9 gene promoter:
         STAT1   p53   Pax-5   AML1a   STAT5A   C/EBPalpha   GATA-1   FAC1   STAT3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHD9 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHD9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

CHD9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHD9 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P053041:  view genomic region     (about GC identifiers)

Start:
53,088,945 bp from pter      End:
53,363,062 bp from pter
Size:
274,118 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHD9_HUMAN, Q3L8U1 (See protein sequence)
Recommended Name: Chromodomain-helicase-DNA-binding protein 9  
Size: 2897 amino acids; 326022 Da
Subunit: Interacts with PPARA. Probably interacts with ESR1 and NR1I3
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAF24170.1; Type=Erroneous translation; Note=Wrong choice of frame;
Sequence=BAB14112.1; Type=Erroneous initiation;
Secondary accessions: B2RTU2 B9ZVQ0 O15025 Q1WF12 Q6DTK9 Q9H9V7 Q9UHM2
Alternative splicing: 3 isoforms:  Q3L8U1-1   Q3L8U1-2   Q3L8U1-3   

Explore the universe of human proteins at neXtProt for CHD9: NX_Q3L8U1

Explore proteomics data for CHD9 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on serine and tyrosine residues
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3L8U1

  • 4/43 DME Specific Peptides for CHD9 (Q3L8U1) (see all 43)
     GAEEKIL  DSDWNPQ  KASFVAS  MCRRVCR 

    CHD9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHD9 Protein Expression
    REFSEQ proteins: NP_079410.4  
    ENSEMBL proteins: 
     ENSP00000457466   ENSP00000456793   ENSP00000455307   ENSP00000457929   ENSP00000381522  
     ENSP00000460155   ENSP00000457355   ENSP00000456415   ENSP00000462685   ENSP00000462008  
     ENSP00000396345  
    Reactome Protein details: Q3L8U1
    Human Recombinant Protein Products for CHD9: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHD9 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--

    CHD9 for ontologies           About GeneDecksing



    CHD9 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CHD9 

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    Cloud-Clone Corp. ELISAs for CHD9 
    Cloud-Clone Corp. CLIAs for CHD9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR000953 Chromo_domain/shadow
     IPR000330 SNF2_N
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR006576 BRK_domain

    Graphical View of Domain Structure for InterPro Entry Q3L8U1

    ProtoNet protein and cluster: Q3L8U1

    3 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB000953 Chromo domain
    IPB006576 Domain in transcription and CHROMO domain helicase


    UniProtKB/Swiss-Prot: CHD9_HUMAN, Q3L8U1
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 2 chromo domains
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    CHD9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHD9_HUMAN, Q3L8U1
    Function: Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a
    ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T-rich DNA.
    Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of
    progenitors during osteogenesis (By similarity)
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding IPI16554032
    GO:0005524ATP binding IEA--
         
    CHD9 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHD9 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHD9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHD9 

    miRNA
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    miRTarBase miRNAs that target CHD9:
    hsa-mir-210 (MIRT003181)

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    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate CHD9 (see all 140):
    hsa-miR-124* hsa-miR-376b hsa-miR-106a hsa-miR-519a hsa-miR-208b hsa-miR-376a* hsa-miR-92b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidCHD9 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHD9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)0.74
    Fatty acid, triacylglycerol, and ketone body metabolism0.52
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for CHD9
        Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
    Metabolism
    Fatty acid, triacylglycerol, and ketone body metabolism
    Metabolism of lipids and lipoproteins



    CHD9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHD9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/103 Interacting proteins for CHD9 (Q3L8U11, 3 ENSP000003815224) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPARAQ078691, 3, ENSP000002627354EBI-960730,EBI-78615 I2D: score=1 STRING: ENSP00000262735
    MED19A0JLT23, ENSP000003373404STRING: ENSP00000337340 I2D: score=1 
    NR3C1P041503, ENSP000002315094I2D: score=1 STRING: ENSP00000231509
    ESR1P033723, ENSP000002062494I2D: score=2 STRING: ENSP00000206249
    RXRAP197933, ENSP000004196924I2D: score=1 STRING: ENSP00000419692
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0016568chromatin modification IEA--
    GO:0044255cellular lipid metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--

    CHD9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHD9

    Search CenterWatch for drugs/clinical trials and news about CHD9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHD9 gene: 
    NM_025134.4  

    Unigene Clusters for CHD9:

    Chromodomain helicase DNA binding protein 9
    Hs.59159  [show with all ESTs], Hs.622347
    Unigene Representative Sequences: DQ333316, AY243504
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000566029(uc002egy.3 uc002ehb.3 uc002ehf.3 uc010cbw.3)
    ENST00000561869 ENST00000565832 ENST00000564582 ENST00000564845 ENST00000563410
    ENST00000398510 ENST00000562785 ENST00000564255 ENST00000565803(uc002ehd.2)
    ENST00000569794 ENST00000565442 ENST00000562791 ENST00000569225(uc002ehe.1)
    ENST00000219084 ENST00000565119 ENST00000562806 ENST00000564600
    miRNA
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    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate CHD9 (see all 140):
    hsa-miR-124* hsa-miR-376b hsa-miR-106a hsa-miR-519a hsa-miR-208b hsa-miR-376a* hsa-miR-92b hsa-miR-520b
    SwitchGear 3'UTR luciferase reporter plasmidCHD9 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHD9

    Additional mRNA sequence: AY243504.1 

    24/25 DOTS entries (see all 25):

    DT.40234597  DT.451990  DT.100744035  DT.120682003  DT.100018802  DT.97763956  DT.95268432  DT.40296262 
    DT.100698940  DT.40237799  DT.304267  DT.91702075  DT.100684135  DT.100697831  DT.75136672  DT.86839773 
    DT.120682027  DT.40280710  DT.95268431  DT.97788608  DT.120681981  DT.120682081  DT.307234  DT.407404 

    24/240 AceView cDNA sequences (see all 240):

    AA187134 AA418399 AK022582 BF063386 AW194982 BX954276 CF143532 AI961562 
    BX113577 AW473068 AW167036 BU633178 AI383165 AK092208 CR609999 BU166728 
    AL597384 AI675058 AI377264 CB163655 AA496960 AW439132 CA393611 R79591 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for CHD9 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                  -                                                         
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                  -                                                                                                         

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b ^ 37
    SP1:                                                  -     -                                               -                     
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CHD9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHD9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAATATGGT
    CHD9 Expression
    About this image


    See CHD9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHD9

    SOURCE GeneReport for Unigene clusters: Hs.59159 Hs.622347

    UniProtKB/Swiss-Prot: CHD9_HUMAN, Q3L8U1
    Tissue specificity: Widely expressed at low levels. In bone marrow, expression is restricted to osteoprogenitor
    cells adjacent to mature osteoblasts

        SABiosciences Expression via Pathway-Focused PCR Arrays including CHD9: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat
              PPAR Targets in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHD9 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chd91 , 5 chromodomain helicase DNA binding protein 91, 5 87.63(n)1
    91.83(a)1
      8 (44.25 cM)5
    1091511  NM_177224.21  NP_796198.11 
     908288355 
    chicken
    (Gallus gallus)
    Aves CHD91 chromodomain helicase DNA binding protein 9 81.29(n)
    86.47(a)
      415722  XM_414088.3  XP_414088.3 
    lizard
    (Anolis carolinensis)
    Reptilia CHD96
    chromodomain helicase DNA binding protein 9
    81(a)
    1 ↔ 1
    LGc(363118-428314)
    zebrafish
    (Danio rerio)
    Actinopterygii chd91 chromodomain helicase DNA binding protein 9 65.48(n)
    72.04(a)
      572355  XM_001922501.3  XP_001922536.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta kis6
    kismet
    17(a)
    1 → many
    2L(210735-250823)
    worm
    (Caenorhabditis elegans)
    Secernentea chd-76
    Protein CHD-7
    25(a)
    1 → many
    I(4685868-4698575)


    ENSEMBL Gene Tree for CHD9 (if available)
    TreeFam Gene Tree for CHD9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHD9 gene
    CHD62  CHD52  CHD42  CHD12  CHD72  CHD82  CHD32  CHD22  
    11 SIMAP similar genes for CHD9 using alignment to 10 protein entries:     CHD9_HUMAN (see all proteins):
    CHD2    CHD8    CHD7    CHD6    SMARCA5    CHD5
    DKFZp434K213    DKFZp434P202    CHD1L    HELLS    SMARCA1

    CHD9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4954 SNPs in CHD9 are shown (see all 4954)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs129257431,2
    A--53086961(+) ctgctC/Tctcct 1 -- us2k10--------
    rs129212741,2
    A--53086967(+) ctcctC/Gctctt 1 -- us2k10--------
    rs129257561,2
    A--53086974(+) tcttcC/Ttcctc 1 -- us2k10--------
    rs287519231,2
    --53087168(+) CTCCTC/GCTGCT 1 -- us2k10--------
    rs106813841,2
    C--53087173(+) CTCCTCCT/-GCTCC 1 -- cds11Minor allele frequency- -:0.00NA 2
    rs3688439171,2
    C--53087183(+) CTCCTC/GCTCCT 1 -- us2k10--------
    rs133318311,2
    C,F--53087196(+) tcctcC/Tttctc 1 -- us2k14Minor allele frequency- T:0.06WA NA EA 360
    rs1904198471,2
    --53087215(+) CCTCCC/TTGTCC 1 -- us2k10--------
    rs1912385721,2
    --53087244(+) CACTTC/TGACCA 1 -- us2k10--------
    rs80550631,2
    A,H--53087294(+) CACACT/ACACAC 1 -- us2k14Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for CHD9 (53088945 - 53338945 bp, first 250kb of CHD9)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for CHD9 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671644CNV Deletion23128226
    esv1370771CNV Insertion17803354
    nsv510419CNV Loss20534489
    nsv833232CNV Loss17160897
    nsv9443CNV Loss18304495
    nsv827652CNV Loss20364138
    nsv906665CNV Loss21882294
    esv21460CNV Loss19812545
    nsv906666CNV Loss21882294
    nsv483048CNV Gain15286789

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CHD9:    About MalaCards
    gamma chain deficiency    


    CHD9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHD9
    Human Genome Epidemiology (HuGE) Navigator: CHD9 (1 document)

    Export disorders for CHD9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHD9 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with CHD9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex. (PubMed id 16554032)1, 2 Surapureddi S.... Reddy J.K. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Characterization and functional analysis of CReMM, a novel chromodomain helicase DNA-binding protein. (PubMed id 16095617)1, 2 Shur I. and Benayahu D. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 80205 HGNC: 25701 AceView: CHD9 Ensembl:ENSG00000177200 euGenes: HUgn80205
    ECgene: CHD9 H-InvDB: CHD9

    (According to HUGE)
    About This Section
    HUGE: KIAA0308

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHD9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHD9 gene:
    Search GeneIP for patents involving CHD9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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