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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHD6 Gene

protein-coding   GIFtS: 54
GCID: GC20M040030

Chromodomain Helicase DNA Binding Protein 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromodomain Helicase DNA Binding Protein 61 2     Chromodomain-Helicase-DNA-Binding Protein 62
Radiation-Induced Gene B Protein2 3     Helicase C-Terminal Domain- And SNF2 N-Terminal Domain-Containing Protein2
CHD-62 3     EC 3.6.4.123
CHD52 3     KIAA13353
RIGB2 3     EC 3.6.18
ATP-Dependent Helicase CHD62 3     

External Ids:    HGNC: 190571   Entrez Gene: 841812   Ensembl: ENSG000001241777   UniProtKB: Q8TD263   

Export aliases for CHD6 gene to outside databases

Previous GC identifers: GC20M039721 GC20M040669 GC20M040716 GC20M039464 GC20M036768


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHD6 Gene:
This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two
chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin
to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member
of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional
repressor and is involved in the cellular repression of influenza virus replication. (provided by RefSeq, Jul
2013)

GeneCards Summary for CHD6 Gene: 
CHD6 (chromodomain helicase DNA binding protein 6) is a protein-coding gene. Diseases associated with CHD6 include pitt-hopkins syndrome, and developmental coordination disorder. GO annotations related to this gene include chromatin binding and ATP-dependent helicase activity. An important paralog of this gene is CHD5.

UniProtKB/Swiss-Prot: CHD6_HUMAN, Q8TD26
Function: Probable transcription regulator




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHD6 gene promoter:
         TBP   ER-alpha   E2F-4   E2F-3a   E2F-5   E2F-2   Evi-1   E2F   E2F-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHD6 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHD6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q12   Ensembl cytogenetic band:  20q12   HGNC cytogenetic band: 20q12

CHD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHD6 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M040030:  view genomic region     (about GC identifiers)

Start:
40,030,741 bp from pter      End:
40,247,133 bp from pter
Size:
216,393 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHD6_HUMAN, Q8TD26 (See protein sequence)
Recommended Name: Chromodomain-helicase-DNA-binding protein 6  
Size: 2715 amino acids; 305412 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAK56405.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAN59903.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15325.1;
Type=Miscellaneous discrepancy; Note=The sequence differs from position 1528 onward for unknown reasons;
Sequence=CAI21743.1; Type=Erroneous gene model prediction; Sequence=CAI22254.1; Type=Erroneous gene model
prediction;
1 PDB 3D structure from and Proteopedia for CHD6:
2EPB (3D)    
Secondary accessions: Q5JYQ0 Q5TGZ9 Q5TH00 Q5TH01 Q8IZR2 Q8WTY0 Q9H4H6 Q9H6D4 Q9NTT7 Q9P2L1
Alternative splicing: 3 isoforms:  Q8TD26-1   Q8TD26-2   Q8TD26-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHD6: NX_Q8TD26

Explore proteomics data for CHD6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TD26

  • 4/37 DME Specific Peptides for CHD6 (Q8TD26) (see all 37)
     GIHGPFL  GAEEKIL  DSDWNPQ  KASFVAS 

    CHD6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHD6 Protein Expression
    REFSEQ proteins: NP_115597.3  
    ENSEMBL proteins: 
     ENSP00000362330   ENSP00000404637   ENSP00000362319   ENSP00000392503   ENSP00000308684  

    Human Recombinant Protein Products for CHD6: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHD6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS12592387

    CHD6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/10 InterPro protein domains (see all 10):
     IPR000953 Chromo_domain/shadow
     IPR000330 SNF2_N
     IPR001005 SANT/Myb
     IPR023780 Chromo_domain
     IPR002464 DNA/RNA_helicase_DEAH_CS

    Graphical View of Domain Structure for InterPro Entry Q8TD26

    ProtoNet protein and cluster: Q8TD26

    4 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB000953 Chromo domain
    IPB002464 ATP-dependent helicase
    IPB006576 Domain in transcription and CHROMO domain helicase


    UniProtKB/Swiss-Prot: CHD6_HUMAN, Q8TD26
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 2 chromo domains
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    CHD6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHD6_HUMAN, Q8TD26
    Function: Probable transcription regulator
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding NAS12592387
    GO:0004386helicase activity ----
    GO:0005515protein binding ----
         
    CHD6 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Chd6):
     behavior/neurological  no phenotypic analysis 

    CHD6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Chd6tm1.2Fier for CHD6

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHD6 
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate CHD6 (see all 45):
    hsa-miR-15a hsa-miR-374a hsa-miR-650 hsa-miR-218 hsa-miR-424 hsa-miR-3613-3p hsa-miR-3612 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidCHD6 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/8 Interacting proteins for CHD6 (Q8TD262, 3 ENSP000003623304) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZFYVE9O954052, 3MINT-62050 I2D: score=3 
    NFE2L2Q162363, ENSP000003802524I2D: score=1 STRING: ENSP00000380252
    CHD3Q128733, ENSP000003697164I2D: score=1 STRING: ENSP00000369716
    ARAFP103983, ENSP000003662444I2D: score=3 STRING: ENSP00000366244
    TOLLIPQ9H0E23, ENSP000003147334I2D: score=3 STRING: ENSP00000314733
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006338chromatin remodeling NAS12592387
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS12592387
    GO:0007399nervous system development NAS12592387

    CHD6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHD6

    Search CenterWatch for drugs/clinical trials and news about CHD6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHD6 gene: 
    NM_032221.4  

    Unigene Cluster for CHD6:

    Chromodomain helicase DNA binding protein 6
    Hs.740645  [show with all ESTs]
    Unigene Representative Sequence: NM_032221
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373233(uc002xjz.1 uc002xkb.1 uc002xka.1 uc002xkd.2)
    ENST00000480022 ENST00000440697 ENST00000476641 ENST00000470470 ENST00000373222(uc002xkc.3)
    ENST00000482596 ENST00000440647 ENST00000309279
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHD6
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate CHD6 (see all 45):
    hsa-miR-15a hsa-miR-374a hsa-miR-650 hsa-miR-218 hsa-miR-424 hsa-miR-3613-3p hsa-miR-3612 hsa-miR-15b
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    Additional mRNA sequence: 

    AB037756.2 AF525085.1 AK091551.1 AK098144.1 AK296955.1 AY034072.1 BC012516.1 BC021907.1 
    BC039860.1 BC040016.1 CR749575.1 

    18 DOTS entries:

    DT.454782  DT.91754297  DT.97776189  DT.99964693  DT.100827804  DT.75139920  DT.91743864  DT.91973049 
    DT.97846470  DT.433435  DT.91945805  DT.120802089  DT.120802096  DT.65287467  DT.91754296  DT.92414739 
    DT.97824786  DT.99936870 

    24/208 AceView cDNA sequences (see all 208):

    AB037756 BM973992 BG059766 BQ018949 AI674871 CD676498 AK098144 BP345468 
    AI278680 BM988023 AI801470 AW150646 AI492625 AA436366 BQ029010 BX112863 
    BE670889 BF344174 AW025853 AA456310 BM672200 BU619922 CA433577 AA456300 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for CHD6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                    -     -     -     -                                                                                                                     
    SP2:                    -                 -     -                                                                                                               
    SP3:                                                                          -     -                                                                           
    SP4:                                                                                                                                                            
    SP5:                    -     -     -     -     -                                                                                                               

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36 ^ 37 ^ 38a · 38b ^ 39 ^ 40a · 40b
    SP1:                                                                                                              -                           
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for CHD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGAAAAAA
    CHD6 Expression
    About this image


    See CHD6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHD6

    SOURCE GeneReport for Unigene cluster: Hs.740645

    UniProtKB/Swiss-Prot: CHD6_HUMAN, Q8TD26
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including CHD6: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CHD6 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chd61 , 5 chromodomain helicase DNA binding protein 61, 5 87.53(n)1
    88.91(a)1
      2 (80.98 cM)5
    713891  NM_173368.21  NP_775544.21 
     1609469785 
    chicken
    (Gallus gallus)
    Aves CHD61 chromodomain helicase DNA binding protein 6 72.45(n)
    75.17(a)
      419127  XM_003642445.1  XP_003642493.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHD66
    Uncharacterized protein
    68(a)
    1 ↔ 1
    4(134972594-135042555)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.162572 Xenopus laevis transcribed sequences 76.16(n)    BJ068564.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chd61 chromodomain helicase DNA binding protein 6 65.82(n)
    68.69(a)
      570753  XM_694268.5  XP_699360.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta kis6
    kismet
    16(a)
    1 → many
    2L(210735-250823)
    worm
    (Caenorhabditis elegans)
    Secernentea chd-76
    Protein CHD-7
    24(a)
    1 → many
    I(4685868-4698575)


    ENSEMBL Gene Tree for CHD6 (if available)
    TreeFam Gene Tree for CHD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHD6 gene
    CHD52  CHD92  CHD42  CHD12  CHD72  CHD82  CHD32  CHD22  
    4 SIMAP similar genes for CHD6 using alignment to 3 protein entries:     CHD6_HUMAN (see all proteins):
    CHD8    CHD9    CHD7    HELLS

    CHD6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4380 SNPs in CHD6 are shown (see all 4380)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1499705721,2
    Cuntested136856269(+) GGGGCA/GATAAT 2 I syn10--------
    rs1453541661,2
    --36768717(+) AGAAGC/TCTGAA 1 -- ds50010--------
    rs1900108221,2
    --36768745(+) TACAGA/TTTCCA 1 -- ds50010--------
    rs1476579311,2
    C--36768829(+) AGGTTA/GTAAGT 1 -- ds50010--------
    rs26645461,2
    C--36768892(+) ACAAAA/GAAAAC 1 -- ut310--------
    rs60653491,2
    H--36768948(+) CAAGAT/CACAGG 1 -- ut31 ese34Minor allele frequency- C:0.00NS EA 420
    rs10477721,2
    C,F,H--36769010(-) TATCAA/CGTAGA 1 -- ut3117Minor allele frequency- C:0.11MN NS EA NA WA 2516
    rs1822857261,2
    C--36769209(+) TTATAA/GACCAT 1 -- ut310--------
    rs1144249561,2
    C,F--36769232(+) GATGTC/TATTAA 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs119060441,2
    C,H--36769392(+) TGCTCG/ATTTTA 1 -- ut311Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for CHD6 (40030741 - 40247133 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CHD6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2460578CNV Deletion19546169
    nsv3382CNV Insertion18451855
    esv268315CNV Insertion20981092
    nsv510786CNV Loss20534489
    nsv3381CNV Loss18451855
    nsv833984CNV Loss17160897
    nsv178957CNV Loss16902084


    Human Gene Mutation Database (HGMD): CHD6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHD6
    DNA2.0 Custom Variant and Variant Library Synthesis for CHD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for CHD6:    About MalaCards
    pitt-hopkins syndrome    developmental coordination disorder    brachydactyly    mental retardation

    1 disease from the University of Copenhagen DISEASES database for CHD6:
    Developmental coordination disorder

    CHD6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHD6
    Human Genome Epidemiology (HuGE) Navigator: CHD6 (2 documents)

    Export disorders for CHD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHD6 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with CHD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases. (PubMed id 11889561)1, 2, 3 Schuster E.F. and Stoeger R.J. (2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    8. CHD6, a cellular repressor of influenza virus replicat ion, is degraded in human alveolar epithelial cells and mice lungs during infect ion. (PubMed id 23408615)1 Alfonso R....Nieto A. (2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    10. Multiple loci influencing hippocampal degeneration ide ntified by genome scan. (PubMed id 22745009)1 Melville S.A....Farrer L.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84181 HGNC: 19057 AceView: CHD6 Ensembl:ENSG00000124177 euGenes: HUgn84181
    ECgene: CHD6 H-InvDB: CHD6

    (According to HUGE)
    About This Section
    HUGE: KIAA1335

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHD6 gene:
    Search GeneIP for patents involving CHD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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