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Aliases for CHD4 Gene

Aliases for CHD4 Gene

  • Chromodomain Helicase DNA Binding Protein 4 2 3 5
  • Mi-2 Autoantigen 218 KDa Protein 3 4
  • ATP-Dependent Helicase CHD4 3 4
  • Mi2-BETA 3 4
  • CHD-4 3 4
  • Chromodomain-Helicase-DNA-Binding Protein 4 3
  • EC 3.6.4.12 4
  • EC 3.6.1 58
  • SIHIWES 3
  • Mi-2b 3

External Ids for CHD4 Gene

Previous GeneCards Identifiers for CHD4 Gene

  • GC12M006534
  • GC12M006653
  • GC12M006558
  • GC12M006549
  • GC12M006679
  • GC12M006533

Summaries for CHD4 Gene

Entrez Gene Summary for CHD4 Gene

  • The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. Somatic mutations in this gene are associated with serous endometrial tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for CHD4 Gene

CHD4 (Chromodomain Helicase DNA Binding Protein 4) is a Protein Coding gene. Diseases associated with CHD4 include Sifrim-Hitz-Weiss Syndrome and Dermatomyositis. Among its related pathways are Chromatin organization and PI3K-Akt signaling pathway. GO annotations related to this gene include hydrolase activity and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is CHD5.

UniProtKB/Swiss-Prot for CHD4 Gene

  • Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

Gene Wiki entry for CHD4 Gene

Additional gene information for CHD4 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD4 Gene

Genomics for CHD4 Gene

Regulatory Elements for CHD4 Gene

Enhancers for CHD4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006940 1.9 FANTOM5 ENCODE dbSUPER 75.9 -346.2 -346183 25 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ZNF384 CHD4 ENSG00000219410 ENSG00000247853 SPSB2 NCAPD2 SCARNA12 ING4 ENSG00000256967 EMG1
GH12H006459 1.4 Ensembl ENCODE dbSUPER 70.7 +145.3 145333 6 HDGF PKNOX1 ZFP64 BMI1 ZNF143 ZNF207 ATF7 ETV6 RUNX3 CREM ZNF384 ENSG00000219410 CHD4 ENSG00000247853 TAPBPL MRPL51 VAMP1 P3H3 NOP2 SCARNA12
GH12H006923 1.7 FANTOM5 ENCODE dbSUPER 51.6 -319.7 -319675 6 HDGF ARID4B SIN3A ZNF2 YY1 ZNF143 FOS DEK PAF1 SP3 ZNF384 CHD4 ENSG00000219410 LRRC23 ENSG00000247853 SCARNA12 EMG1 PHB2 RPL13P5 NCAPD2
GH12H006530 1.4 ENCODE dbSUPER 54.6 +70.4 70381 12 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF384 CHD4 ENSG00000219410 NCAPD2 ENSG00000247853 NOP2 SPSB2 MRPL51 ENSG00000256967 ING4
GH12H006602 1.7 FANTOM5 ENCODE dbSUPER 38.8 +1.7 1749 7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF384 ENSG00000219410 ENSG00000247853 CHD4 NOP2 ING4 NCAPD2 SPSB2 EMG1 SCARNA12
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHD4 on UCSC Golden Path with GeneCards custom track

Promoters for CHD4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048323 876 2001 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 GLIS2 ZNF207 ATF7 RUNX3

Genomic Location for CHD4 Gene

Chromosome:
12
Start:
6,570,082 bp from pter
End:
6,607,476 bp from pter
Size:
37,395 bases
Orientation:
Minus strand

Genomic View for CHD4 Gene

Genes around CHD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHD4 Gene

Proteins for CHD4 Gene

  • Protein details for CHD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14839-CHD4_HUMAN
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 4
    Protein Accession:
    Q14839
    Secondary Accessions:
    • Q8IXZ5

    Protein attributes for CHD4 Gene

    Size:
    1912 amino acids
    Molecular mass:
    218005 Da
    Quaternary structure:
    • Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (By similarity). Interacts directly with IKFZ1 in the NuRD complex. Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex (PubMed:9804427, PubMed:10204490, PubMed:15454082). Part of a complex containing ATR and HDAC2 (PubMed:10545197). Interacts with TRIM27 (PubMed:14530259). Interacts with ZGPAT; the interaction is direct (PubMed:19644445). Interacts with BCL6 (PubMed:15454082). Interacts with BRD4 (PubMed:21555454). Interacts with PCNT (PubMed:17626165). Interacts with SETX (PubMed:23149945). Interacts with HDAC1 (PubMed:27616479).
    Miscellaneous:
    • One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis.

    Three dimensional structures from OCA and Proteopedia for CHD4 Gene

    Alternative splice isoforms for CHD4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHD4 Gene

Selected DME Specific Peptides for CHD4 Gene

Q14839:
  • AGNKPANAVLHKVL
  • RWQDIQND
  • DEMGLGKT
  • DEAHRLK
  • TGTPLQN
  • VLLTSYELI
  • KMMLTHLVVRPG
  • ETFADGVPREGLSRQ
  • GHRVLIF
  • NQSKFFR
  • FLLSTRA
  • YKYERIDGGITG
  • NEYLSSFKVA
  • AGGLGINL
  • FLYSLYKEGH
  • RVLIFSQM
  • PEGKWSCPHCE
  • RAHRIGQ
  • DSDWNPH
  • GLGKTVQ
  • LSTRAGGLG

Post-translational modifications for CHD4 Gene

  • Ubiquitination at Lys504, posLast=10571057, Lys1092, posLast=18371837, Lys1852, posLast=18551855, and Lys1865
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CHD4 (CHD-4)

Domains & Families for CHD4 Gene

Gene Families for CHD4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for CHD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14839

UniProtKB/Swiss-Prot:

CHD4_HUMAN :
  • Belongs to the SNF2/RAD54 helicase family.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with CHD4: view

Function for CHD4 Gene

Molecular function for CHD4 Gene

GENATLAS Biochemistry:
DNA binding protein with two chromatin organization (chromo) domains,and a helicase domain,4,component of the chromatin remodeling complex
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones.

Enzyme Numbers (IUBMB) for CHD4 Gene

Phenotypes From GWAS Catalog for CHD4 Gene

Gene Ontology (GO) - Molecular Function for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000978 contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 contributes_to RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 22926524
GO:0003677 DNA binding TAS 9326634
genes like me logo Genes that share ontologies with CHD4: view
genes like me logo Genes that share phenotypes with CHD4: view

Animal Models for CHD4 Gene

MGI Knock Outs for CHD4:

Animal Model Products

CRISPR Products

miRNA for CHD4 Gene

miRTarBase miRNAs that target CHD4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHD4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHD4 Gene

Localization for CHD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHD4 Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates with centrosomes in interphase. {ECO:0000250 UniProtKB:Q6PDQ2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHD4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 17626165
GO:0005813 centrosome IDA 17626165
genes like me logo Genes that share ontologies with CHD4: view

Pathways & Interactions for CHD4 Gene

genes like me logo Genes that share pathways with CHD4: view

Pathways by source for CHD4 Gene

Gene Ontology (GO) - Biological Process for CHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006325 chromatin organization IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9326634
genes like me logo Genes that share ontologies with CHD4: view

No data available for SIGNOR curated interactions for CHD4 Gene

Drugs & Compounds for CHD4 Gene

(3) Drugs for CHD4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
ATP Nutra Agonist 0

(1) Additional Compounds for CHD4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CHD4: view

Transcripts for CHD4 Gene

Unigene Clusters for CHD4 Gene

Chromodomain helicase DNA binding protein 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CHD4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CHD4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d ^ 13a · 13b ^ 14a ·
SP1:
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SP13:
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SP18:
SP19: - - - - - - - - - - - - - - - - - - - - - -
SP20:
SP21:
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SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - -
SP30: - - -
SP31: -
SP32: -
SP33:

ExUns: 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b · 26c · 26d ^ 27 ^ 28a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
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SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - - - - - - - - - - - - - - - - - - - - -
SP20:
SP21:
SP22: -
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

ExUns: 28b ^ 29a · 29b · 29c ^ 30a · 30b · 30c ^ 31a · 31b ^ 32a · 32b · 32c ^ 33a · 33b · 33c · 33d ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37 ^ 38a · 38b · 38c ^
SP1:
SP2: -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - - -
SP20:
SP21:
SP22:
SP23: -
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

ExUns: 39a · 39b ^ 40 ^ 41 ^ 42a · 42b ^ 43 ^ 44a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25: -
SP26:
SP27:
SP28:
SP29:
SP30:
SP31:
SP32:
SP33:

Relevant External Links for CHD4 Gene

GeneLoc Exon Structure for
CHD4
ECgene alternative splicing isoforms for
CHD4

Expression for CHD4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHD4 Gene

Protein differential expression in normal tissues from HIPED for CHD4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.5) and Lymph node (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHD4 Gene



Protein tissue co-expression partners for CHD4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CHD4 Gene:

CHD4

SOURCE GeneReport for Unigene cluster for CHD4 Gene:

Hs.162233

Evidence on tissue expression from TISSUES for CHD4 Gene

  • Skin(4.6)
  • Liver(4.5)
  • Nervous system(4.4)
  • Lung(3.7)
  • Eye(3.3)
  • Intestine(3.3)
  • Pancreas(2.9)
  • Heart(2.5)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with CHD4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHD4 Gene

Orthologs for CHD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHD4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHD4 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHD4 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHD4 33 34
  • 94.07 (n)
cow
(Bos Taurus)
Mammalia CHD4 33 34
  • 92.14 (n)
rat
(Rattus norvegicus)
Mammalia Chd4 33
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Chd4 33 16 34
  • 91.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHD4 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHD4 33 34
  • 78.84 (n)
lizard
(Anolis carolinensis)
Reptilia CHD4 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chd4 33
  • 75.12 (n)
Str.16957 33
African clawed frog
(Xenopus laevis)
Amphibia b230399n07-prov 33
zebrafish
(Danio rerio)
Actinopterygii chd4b 34
  • 76 (a)
OneToMany
chd4a 33 34
  • 73.18 (n)
Dr.27188 33
fruit fly
(Drosophila melanogaster)
Insecta Chd3 35 34
  • 54 (a)
Mi-2 34 35
  • 54 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea let-418 33 34
  • 59.33 (n)
chd-3 34
  • 50 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHD1 34
  • 25 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons PKR2 33
  • 53.18 (n)
rice
(Oryza sativa)
Liliopsida Os.10905 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8509 34
  • 57 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2842 33
Species where no ortholog for CHD4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHD4 Gene

ENSEMBL:
Gene Tree for CHD4 (if available)
TreeFam:
Gene Tree for CHD4 (if available)

Paralogs for CHD4 Gene

Paralogs for CHD4 Gene

genes like me logo Genes that share paralogs with CHD4: view

Variants for CHD4 Gene

Sequence variations from dbSNP and Humsavar for CHD4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs201992075 Pathogenic, Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159] 6,581,131(+) AACAA(C/T)GACCT downstream-variant-500B, reference, missense
VAR_077146 Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159]
VAR_077147 Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159]
VAR_077148 Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159]
VAR_077149 Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159]

Structural Variations from Database of Genomic Variants (DGV) for CHD4 Gene

Variant ID Type Subtype PubMed ID
esv1065323 CNV deletion 17803354
esv2027881 CNV deletion 18987734
esv2675369 CNV deletion 23128226
nsv1068116 CNV deletion 25765185
nsv1070086 CNV deletion 25765185
nsv1110891 OTHER inversion 24896259
nsv509452 CNV insertion 20534489
nsv826210 CNV gain 20364138
nsv826211 CNV gain 20364138
nsv832322 CNV loss 17160897
nsv973982 CNV duplication 23825009

Variation tolerance for CHD4 Gene

Residual Variation Intolerance Score: 0.524% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.09; 50.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHD4 Gene

Human Gene Mutation Database (HGMD)
CHD4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHD4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD4 Gene

Disorders for CHD4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CHD4 Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sifrim-hitz-weiss syndrome
  • sihiwes
dermatomyositis
  • amyopathic dermatomyositis
cellular schwannoma
  • cellular neurinoma
- elite association - COSMIC cancer census association via MalaCards
Search CHD4 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CHD4_HUMAN
  • Sifrim-Hitz-Weiss syndrome (SIHIWES) [MIM:617159]: An autosomal dominant syndrome characterized by mental retardation, variable congenital defects affecting cardiac, skeletal, and urogenital systems. Short stature, macrocephaly, hearing impairment, and facial dysmorphism are present in some patients. {ECO:0000269 PubMed:27479907, ECO:0000269 PubMed:27616479}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CHD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHD4
genes like me logo Genes that share disorders with CHD4: view

No data available for Genatlas for CHD4 Gene

Publications for CHD4 Gene

  1. Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. (PMID: 14530259) Shimono Y … Takahashi M (The Journal of biological chemistry 2003) 3 4 22 60
  2. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PMID: 10545197) Schmidt DR … Schreiber SL (Biochemistry 1999) 3 4 22 60
  3. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. (PMID: 9804427) Tong JK … Schreiber SL (Nature 1998) 3 4 22 60
  4. The major dermatomyositis-specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. (PMID: 7575689) Seelig HP … Genth E (Arthritis and rheumatism 1995) 2 3 4 60
  5. CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex. (PMID: 27235397) Low JK … Mackay JP (The Journal of biological chemistry 2016) 2 3 60

Products for CHD4 Gene