CHD4 Gene
protein-coding GIFtS: 63
GCID: GC12M006679
|
|
chromodomain helicase DNA binding protein 4
| |
Aliases
for CHD4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromodomain Helicase DNA Binding Protein 41 2 | | Mi-2 Autoantigen 218 KDa Protein2 3 | | Mi-2b1 2 | | Chromodomain-Helicase-DNA-Binding Protein 42 | | Mi2-BETA1 2 | | EC 3.6.4.123 | | CHD-42 3 | | Mi2-Beta1 | | ATP-Dependent Helicase CHD42 3 | | EC 3.6.18 |
Export aliases for CHD4 gene to outside databasesPrevious GC identifers: GC12M006534 GC12M006653 GC12M006558 GC12M006549 GC12M006533 |
Summaries
for CHD4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHD4:
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosomeremodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients withdermatomyositis develop antibodies against this protein. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CHD4_HUMAN, Q14839Function: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin bydeacetylating histones
Gene Wiki entry for CHD4
|
Genomic Views
for CHD4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHD4 gene promoter:
E2F-3a E2F-4 E2F-5 E2F-2 GATA-2 Max E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHD4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13CHD4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M006679: view genomic region
(about GC identifiers)
Start:
|
6,679,248 bp from pter |
End:
|
6,716,642 bp from pter |
Size:
|
37,395 bases |
Orientation:
|
minus strand |
|
Proteins
for CHD4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHD4_HUMAN, Q14839 (See
protein sequence)Recommended Name: Chromodomain-helicase-DNA-binding protein 4 Size: 1912 amino acids; 218005 Da
Subunit: Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interactsdirectly with IKFZ1 in the NuRD complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interactswith KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (Bysimilarity). Interacts with ZGPAT; the interaction is direct. Interacts with PCNT
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, centrosome. Note=Associates with centrosomes in interphase
Miscellaneous: One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis
5 PDB 3D structures from  and Proteopedia  for CHD4:1MM2 (3D)
1MM3 (3D)
2EE1 (3D)
2L5U (3D)
2L75 (3D)
Secondary accessions: Q8IXZ5Alternative splicing: 2 isoforms: Q14839-1 Q14839-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CHD4: NX_Q14839
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14839
4/21 DME Specific Peptides for CHD4 (Q14839) (see all 21)
CHD4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001264.2
ENSEMBL proteins: ENSP00000440392 ENSP00000440542 ENSP00000437506 ENSP00000444614 ENSP00000312419 ENSP00000349508
Human Recombinant Protein Products for CHD4:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CHD4 for ontologies About GeneDecksing
CHD4 Antibody Products:
Assay Products for CHD4: |
Protein
Domains /
Families
for CHD4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHD4 for domains About GeneDecksing
5/17 InterPro domains/families (see all 17):Graphical View of Domain Structure for InterPro Entry Q14839ProtoNet protein and cluster: Q14839 5/7 Blocks protein families (see all 7): IPB000330 SNF2 related domain IPB000953 Chromo domain IPB001841 Zn-finger IPB001965 Zn-finger-like IPB002464 ATP-dependent helicase
UniProtKB/Swiss-Prot: CHD4_HUMAN, Q14839Similarity: Belongs to the SNF2/RAD54 helicase familySimilarity: Contains 2 chromo domainsSimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domainSimilarity: Contains 2 PHD-type zinc fingers |
Function
for CHD4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CHD4_HUMAN, Q14839Function: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin bydeacetylating histonesCatalytic activity: ATP + H(2)O = ADP + phosphate Genatlas biochemistry entry for CHD4:DNA binding protein with two chromatin organization (chromo) domains,and a helicase domain,4,component of the chromatinremodeling complex
Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table
CHD4 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for CHD4:
4 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Chd4):
CHD4 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out Chd4tm1.2Kge for CHD4
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHD4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHD4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHD4 (NM_001273) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHD4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD4 |
|
Pathways & Interactions
for CHD4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcription_Sin3 and NuRD in transcription regulation | | | 2 | Signaling events mediated by HDAC Class I | | | 3 | DNA Methylation and Transcriptional Repression | | | 4 | Chromatin Regulation / Acetylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for CHD4
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CHD4
1 
Cell Signaling Technology (CST) Pathway for CHD4
1  GeneGo (Thomson Reuters) Pathway for CHD4
1  BioSystems Pathway for CHD4
CHD4 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHD4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/677 Interacting proteins for CHD4 (Q148391, 2, 3 ENSP000003495084) via UniProtKB, MINT, STRING, and/or I2D (see all 677)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 9326634 | | GO:0016568 | chromatin modification |
IEA | -- |
CHD4 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHD4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CHD4
Search CenterWatch for drugs/clinical trials and news about CHD4
|
Transcripts
for CHD4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHD4 gene: NM_001273.2 Unigene Cluster for CHD4: Chromodomain helicase DNA binding protein 4 Hs.162233 [show with all ESTs]Unigene Representative Sequence: BC03859616 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000544484 ENST00000544040 ENST00000535717 ENST00000542717 ENST00000536301
ENST00000540960 ENST00000537634 ENST00000545083 ENST00000536999 ENST00000535810
ENST00000545942 ENST00000430771 ENST00000545584 ENST00000539431 ENST00000309577(uc001qpp.3)
ENST00000357008(uc001qpn.3 uc001qpo.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHD4 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHD4
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHD4 (NM_001273) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHD4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD4 |
Additional cDNA sequence: AK128741.1 BC014964.1 BC025962.1 BC038596.1 CR936680.1 X86691.1 24/36 DOTS entries (see all 36): DT.450173 DT.91770737 DT.92066676 DT.101965737 DT.100039470 DT.121195024 DT.100831846 DT.95122233 DT.121194989 DT.121195105 DT.100831848 DT.95122343 DT.100831851 DT.121195138 DT.97814519 DT.100039469 DT.100831843 DT.75111364 DT.92040119 DT.95122287 DT.100032934 DT.100831845 DT.102835948 DT.121194993 24/213 AceView cDNA sequences (see all 213): BM711408 BQ943412 BQ215798 BE043063 CA397022 BX374570 BE080730 CN484262 BQ877361 BU855947 BQ893361 BQ437443 BQ880111 AU130723 BM556759 AI806023 BQ425890 T11014 BQ687173 T08340 AI630849 BQ431808 BQ953179 BC025962
GeneLoc Exon Structure
5/33 Alternative Splicing Database (ASD) splice patterns (SP) for CHD4 (see all 33) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13a | · | 13b | ^ | 14a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 14b | · | 14c | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18 | ^ | 19a | · | 19b | ^ | 20a | · | 20b | ^ | 21a | · | 21b | ^ | 22 | ^ | 23a | · | 23b | ^ | 24a | · | 24b | ^ | 25 | ^ | 26a | · | 26b | · | 26c | · | 26d | ^ | 27 | ^ | 28a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 28b | ^ | 29a | · | 29b | · | 29c | ^ | 30a | · | 30b | · | 30c | ^ | 31a | · | 31b | ^ | 32a | · | 32b | · | 32c | ^ | 33a | · | 33b | · | 33c | · | 33d | ^ | 34a | · | 34b | ^ | 35a | · | 35b | ^ | 36a | · | 36b | ^ | 37 | ^ | 38a | · | 38b | · | 38c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 39a | · | 39b | ^ | 40 | ^ | 41 | ^ | 42a | · | 42b | ^ | 43 | ^ | 44a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CHD4
|
Expression
for CHD4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGCAGTAGC
About this image
See CHD4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHD4
SOURCE GeneReport for Unigene cluster: Hs.162233
SABiosciences Expression via Pathway-Focused PCR Arrays including CHD4:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHD4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHD4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD4 |
Orthologs
for CHD4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CHD4 gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CHD41 |
chromodomain helicase DNA binding protein 4 |
79.15(n)
92.03(a) |
|
418278 XM_003640441.1 XP_003640489.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CHD46 |
-- |
90(a) |
1 ↔ 1 |
GL343381.1(735255-763912) |
African clawed frog
(Xenopus laevis) |
Amphibia |
b230399n07-prov2 |
chromodomain helicase DNA binding protein 4 |
78.57(n) |
|
BC046866.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.271882 |
Transcribed sequence with moderate similarity to protein more |
79.65(n) |
|
CA473451.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Mi-21 , 3 |
chromatin assembly/disassembly ATP dependent
DNA more3
CG8103-PA1 |
62(a)
(best of 2)3
61.01(n)1
61.37(a)1 |
|
401701 NM_001014591.21 NP_001014591.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
let-4181 |
Protein LET-418 |
56.81(n)
56.51(a) |
|
178970 NM_072122.3 NP_504523.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PKR26GYM6 |
CHD3-type chromatin-remodeling factor PICKLE |
35(a)34(a) |
many ↔ manymany ↔ many |
4(15431350-15438678) 2(10713807-10723986) |
rice
(Oryza sativa) |
Liliopsida |
Os.109052 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
70.83(n) |
|
NM_187372.1 |
ENSEMBL Gene Tree for CHD4 (if available)
TreeFam Gene Tree for CHD4 (if available) |
Paralogs
for CHD4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHD4 gene
- CHD62 CHD52 CHD82 CHD32 CHD92 CHD12 CHD72 CHD22
13 SIMAP similar genes for CHD4 using alignment to 5 protein entries: CHD4_HUMAN (see all proteins):DKFZp434P202 DKFZp434K213 AIRE CHD5 CHD3 SHPRH
SP110 PHF21A SMARCA5 CHD1L CHD8 HELLS
SMARCA1
CHD4 for paralogs About GeneDecksing
|
Genomic Variants
for CHD4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHD4 (6679248 - 6716642 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CHD4
2 Indels: 45071 25057 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHD4 |
|
Disorders
/ Diseases
for CHD4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHD4 for disorders About GeneDecksing
OMIM gene information: 603277
OMIM disorders: --
3  diseases for CHD4: About MalaCardsdermatomyositis hematopoiesis breast cancer
1 disease from the University of Copenhagen DISEASES database for CHD4:Right bundle branch block Export disorders for CHD4 gene to outside databases
|
Publications
for CHD4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHD4 gene, integrated from 9 sources (see all 105):
(articles sorted by number of sources associating them with CHD4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The major dermatomyositis specific Mi-2 autoantigen is a presumed helicase involved in transcriptional activation. (PubMed id 7575689)1, 2, 3 Seelig H.P.... Genth E. (1995)
- Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. (PubMed id 10545197)1, 2, 9 Schmidt D.R. and Schreiber S.L. (1999)
- Mi-2 beta associates with BRG1 and RET finger protein at the distinct regions with transcriptional activating and repressing abilities. (PubMed id 14530259)1, 2, 9 Shimono Y....Takahashi M. (2003)
- Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. (PubMed id 9804427)1, 2, 9 Tong J.K....Schreiber S.L. (1998)
- ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. (PubMed id 19644445)1, 2 Li R.... Shang Y. (2009)
- Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. (PubMed id 17626165)1, 2 Sillibourne J.E....Doxsey S.J. (2007)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Engineering a protein scaffold from a PHD finger. (PubMed id 12842043)1, 2 Kwan A.H.Y....Mackay J.P. (2003)
- Two forms of the major antigenic protein of the derma tomyositis-specific Mi-2 autoantigen. (PubMed id 8843877)1, 3 Seelig H.P....Frank M.B. (1996)
|
External Searches for CHD4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHD4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHD4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHD4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CHD4 gene:
Search GeneIP for patents involving CHD4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHD4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHD4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHD4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHD4 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHD4 | | OriGene 3'-UTR Clone for CHD4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHD4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHD4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHD4 | | OriGene Custom Protein Services for CHD4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHD4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHD4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHD4 |
| |
 |  |  |  | |
| | Antibodies & Assays for CHD4 (CHD-4) |
| | | | Search Tocris compounds for CHD4 |
| |  |  |  |  | | | | | | Recombinant Protein for CHD4 |
|
 |
 |
 |
 | | | CHD4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD4 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for CHD4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD4 |
| |  | |
|
|
|
