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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHD3 Gene

protein-coding   GIFtS: 62
GCID: GC17P007788

Chromodomain Helicase DNA Binding Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromodomain Helicase DNA Binding Protein 31 2     Mi2-ALPHA2
Mi-2 Autoantigen 240 KDa Protein2 3     ZFH2
Zinc Finger Helicase2 3     Chromodomain-Helicase-DNA-Binding Protein 32
CHD-32 3     Zinc-Finger Helicase (Snf2-Like)2
ATP-Dependent Helicase CHD32 3     EC 3.6.4.123
hZFH2 3     Mi2-alpha3
Mi-2a2     EC 3.6.18

External Ids:    HGNC: 19181   Entrez Gene: 11072   Ensembl: ENSG000001700047   OMIM: 6021205   UniProtKB: Q128733   

Export aliases for CHD3 gene to outside databases

Previous GC identifers: GC17P008257 GC17P008659 GC17P007730 GC17P007988 GC17P007992 GC17P007732 GC17U900584


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHD3 Gene:
This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo
(chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the
components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the
remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including
transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three
alternatively spliced transcripts encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for CHD3 Gene: 
CHD3 (chromodomain helicase DNA binding protein 3) is a protein-coding gene. Diseases associated with CHD3 include dermatomyositis, and mental retardation, and among its related super-pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include ATP-dependent DNA helicase activity and helicase activity. An important paralog of this gene is CHD6.

UniProtKB/Swiss-Prot: CHD3_HUMAN, Q12873
Function: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by
deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for
spindle organization and centrosome integrity

Gene Wiki entry for CHD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHD3 gene promoter:
         Egr-3   PPAR-alpha   AREB6   Pax-5   HFH-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CHD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

CHD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHD3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007788:  view genomic region     (about GC identifiers)

Start:
7,788,123 bp from pter      End:
7,816,078 bp from pter
Size:
27,956 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHD3_HUMAN, Q12873 (See protein sequence)
Recommended Name: Chromodomain-helicase-DNA-binding protein 3  
Size: 2000 amino acids; 226592 Da
Subunit: Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex.
Interacts with TRIM28 and SERBP1. Interacts (via its C-terminal) with HABP4. Interacts with PCNT; the interaction
regulates centrosome integrity
Subcellular location: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associates
with centrosomes in interphase and mitosis
Miscellaneous: One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis
Sequence caution: Sequence=AAB87383.1; Type=Miscellaneous discrepancy; Note=Differs from position 1967 onward for
unknown reasons;
Secondary accessions: D3DTQ9 E9PG89 Q9Y4I0
Alternative splicing: 3 isoforms:  Q12873-1   Q12873-2   Q12873-3   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for CHD3: NX_Q12873

Explore proteomics data for CHD3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12873

  • 4/23 DME Specific Peptides for CHD3 (Q12873) (see all 23)
     DEAHRLK  TGTPLQN  NQSKFFR  FLLSTRA 

    CHD3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHD3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001005271.2  NP_001005273.1  NP_005843.2  

    ENSEMBL proteins: 
     ENSP00000369716   ENSP00000350907   ENSP00000332628   ENSP00000405861   ENSP00000458861  
     ENSP00000467547   ENSP00000395252   ENSP00000459321   ENSP00000411959  

    Human Recombinant Protein Products for CHD3: 
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    Novus Biologicals CHD3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHD3 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9688266
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA17626165
    GO:0005813centrosome IDA17626165
    GO:0016581NuRD complex IDA17827154

    CHD3 for ontologies           About GeneDecksing



    CHD3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CHD3
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CHD3  (CHD-3 iso3)
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    Novus Biologicals CHD3 Antibodies
    Abcam antibodies for CHD3
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    ThermoFisher Antibody for CHD3
    LSBio Antibodies in human, mouse, rat for CHD3 

    Assay Products for CHD3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHD3 
    Cloud-Clone Corp. CLIAs for CHD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PHF: Zinc fingers, PHD-type

    5/20 InterPro protein domains (see all 20):
     IPR009463 DUF1087
     IPR001841 Znf_RING
     IPR001965 Znf_PHD
     IPR000953 Chromo_domain/shadow
     IPR000330 SNF2_N

    Graphical View of Domain Structure for InterPro Entry Q12873

    ProtoNet protein and cluster: Q12873

    5/7 Blocks protein domains (see all 7):
    IPB000330 SNF2 related domain
    IPB000953 Chromo domain
    IPB001841 Zn-finger
    IPB001965 Zn-finger-like
    IPB002464 ATP-dependent helicase


    UniProtKB/Swiss-Prot: CHD3_HUMAN, Q12873
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 2 chromo domains
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 2 PHD-type zinc fingers


    CHD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHD3_HUMAN, Q12873
    Function: Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by
    deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for
    spindle organization and centrosome integrity
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for CHD3:
    DNA binding protein with two chromatin organization (chromo) domains,and a helicase domain,3,component of the
    chromatin remodeling complex

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004003ATP-dependent DNA helicase activity TAS9326634
    GO:0004386helicase activity NAS9688266
    GO:0005515protein binding IPI12505151
         
    CHD3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHD3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHD3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHD3 

    miRNA
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    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CHD3 (see all 27):
    hsa-miR-485-5p hsa-miR-2110 hsa-miR-575 hsa-miR-450b-3p hsa-miR-548l hsa-miR-3150a-3p hsa-miR-877* hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidCHD3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHD3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35
    2Signaling events mediated by HDAC Class I
    Signaling events mediated by HDAC Class I
    3Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CHD3
        Transcription Sin3 and NuRD in transcription regulation


    1 Cell Signaling Technology (CST) Pathway for CHD3
        Chromatin Regulation / Acetylation

    1 GeneGo (Thomson Reuters) Pathway for CHD3
        Transcription Sin3 and NuRD in transcription regulation

    1 BioSystems Pathway for CHD3
        Signaling events mediated by HDAC Class I



    CHD3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/760 Interacting proteins for CHD3 (Q128731, 2, 3 ENSP000003697164) via UniProtKB, MINT, STRING, and/or I2D (see all 760)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006333chromatin assembly or disassembly IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent NAS9688266
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9326634
    GO:0007051spindle organization IDA17626165

    CHD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHD3

    Search CenterWatch for drugs/clinical trials and news about CHD3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHD3 gene (3 alternative transcripts): 
    NM_001005271.2  NM_001005273.2  NM_005852.3  

    Unigene Cluster for CHD3:

    Chromodomain helicase DNA binding protein 3
    Hs.25601  [show with all ESTs]
    Unigene Representative Sequence: NM_001005271
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380358(uc002gjd.2) ENST00000358181(uc002gjf.2 uc002gjg.1)
    ENST00000330494(uc002gje.2) ENST00000570758 ENST00000574022 ENST00000452447
    ENST00000572579 ENST00000571249 ENST00000479080 ENST00000470531(uc002gjh.2)
    ENST00000466233 ENST00000473376 ENST00000572750 ENST00000439235 ENST00000573936
    ENST00000449744 ENST00000481999(uc002gjj.2)
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHD3
    8/27 QIAGEN miScript miRNA Assays for microRNAs that regulate CHD3 (see all 27):
    hsa-miR-485-5p hsa-miR-2110 hsa-miR-575 hsa-miR-450b-3p hsa-miR-548l hsa-miR-3150a-3p hsa-miR-877* hsa-miR-890
    SwitchGear 3'UTR luciferase reporter plasmidCHD3 3' UTR sequence
    Inhib. RNA
    Products:
         
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHD3
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD3
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHD3

    Additional mRNA sequence: 

    AF064844.1 AK096555.1 AK125928.1 AK296725.1 AK296937.1 AK308362.1 BC110648.1 U08379.1 
    U91543.1 

    24 DOTS entries:

    DT.101955781  DT.91789628  DT.95236710  DT.445459  DT.91907399  DT.92447872  DT.120935860  DT.101957495 
    DT.92447865  DT.86850991  DT.92447876  DT.92447869  DT.100666962  DT.92447864  DT.100790238  DT.120935990 
    DT.121289811  DT.100678541  DT.100821703  DT.92447861  DT.92476134  DT.95226693  DT.97769182  DT.120935877 

    GeneLoc Exon Structure

    5/27 Alternative Splicing Database (ASD) splice patterns (SP) for CHD3 (see all 27)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16a · 16b ^ 17a · 17b · 17c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b ^ 19 ^ 20 ^ 21a · 21b · 21c ^ 22a · 22b ^ 23a · 23b · 23c · 23d ^ 24a · 24b · 24c ^ 25a · 25b ^ 26a · 26b ^ 27 ^ 28a · 28b · 28c ^ 29 ^ 30 ^
    SP1:                                                                                                        -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                -     -                 -                                                   

    ExUns: 31a · 31b ^ 32a · 32b ^ 33a · 33b ^ 34a · 34b ^ 35a · 35b · 35c ^ 36a · 36b · 36c ^ 37a · 37b · 37c · 37d ^ 38 ^ 39a · 39b
    SP1:                                                                                -     -                                       
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CHD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHD3 expression in normal human tissues (normalized intensities)      CHD3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAACCCCC
    CHD3 Expression
    About this image


    CHD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/24 selected tissues (see all 24) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             superior temporal gyrus   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Epithelium (Reproductive System)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See CHD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHD3

    SOURCE GeneReport for Unigene cluster: Hs.25601

    UniProtKB/Swiss-Prot: CHD3_HUMAN, Q12873
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Array including CHD3: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHD3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chd31 , 5 chromodomain helicase DNA binding protein 31, 5 91(n)1
    97.51(a)1
      11 (42.53 cM)5
    2168481  NM_146019.31  NP_666131.31 
     693432735 
    lizard
    (Anolis carolinensis)
    Reptilia CHD36
    chromodomain helicase DNA binding protein 3
    82(a)
    1 ↔ 1
    GL343784.1(58286-133887)
    zebrafish
    (Danio rerio)
    Actinopterygii chd31 chromodomain helicase DNA binding protein 3 71.83(n)
    77.87(a)
      568230  XM_691549.5  XP_696641.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta Mi-23 chromatin assembly/disassembly ATP
    dependent DNA more
    61(a)
    (best of 2)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea chd-36
    let-4186
    Protein let-418
    49(a)
    47(a)
    many ↔ many
    many ↔ many
    X(12846430-12852601)
    V(5826833-5832861)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CHD16
    Chromatin remodeler that regulates various aspects...
    24(a)
    1 → many
    V(505392-509798)


    ENSEMBL Gene Tree for CHD3 (if available)
    TreeFam Gene Tree for CHD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHD3 gene
    CHD62  CHD52  CHD92  CHD42  CHD12  CHD72  CHD82  CHD22  
    9 SIMAP similar genes for CHD3 using alignment to 8 protein entries:     CHD3_HUMAN (see all proteins):
    DKFZp434K213    DKFZp434P202    CHD5    CHD4    AIRE    SMARCA5
    CHD1L    HELLS    SMARCA1

    CHD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/667 SNPs in CHD3 are shown (see all 667)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs340098841,2
    C--7782259(+) AGACT-/G/GT  
            
    ATGAA
    3 -- int11NA 2
    rs732336461,2
    C,F--7786181(+) CCGCCG/AAAGAT 1 -- us2k13Minor allele frequency- A:0.19WA NA 240
    rs1924358781,2
    --7786218(+) GTAGAA/GGAATA 1 -- us2k10--------
    rs1834549351,2
    --7786253(+) GCATGC/GAATGG 1 -- us2k10--------
    rs1885095201,2
    C--7786547(+) ATAACC/TCCTAC 1 -- us2k10--------
    rs37442531,2
    C,F,H--7786699(+) GATTTG/TACTCT 1 -- us2k112Minor allele frequency- T:0.15EA NS 3020
    rs1928857621,2
    --7786707(+) TCTTTC/GCTCTT 1 -- us2k10--------
    rs1480169681,2
    --7786754(+) TTCTCA/GAGTCA 1 -- us2k10--------
    rs1850721641,2
    --7787035(+) TGTGAC/TTTCAA 1 -- us2k10--------
    rs2002242571,2
    C--7787151(+) AAAAA-/AGCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHD3 (7788123 - 7816078 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CHD3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2715608CNV Deletion23290073
    nsv833351CNV Loss17160897
    nsv457660CNV Loss19166990
    nsv907654CNV Loss21882294
    dgv510n67CNV Gain20364138


    Human Gene Mutation Database (HGMD): CHD3
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602120    OMIM disorders: --

    4 diseases for CHD3:    About MalaCards
    dermatomyositis    mental retardation    retinitis    breast cancer


    CHD3 for disorders           About GeneDecksing


    Export disorders for CHD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHD3 gene, integrated from 9 sources (see all 87):
    (articles sorted by number of sources associating them with CHD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the CHD family of proteins. (PubMed id 9326634)1, 2, 3 Woodage T.... Collins F.S. (1997)
    2. Molecular analysis of a major antigenic region of the 240 kD protein of Mi-2 autoantigen. (PubMed id 7560064)1, 2, 3 Ge Q.... Targoff I.N. (1995)
    3. Identification of a human 17p-located cDNA encoding a protein of the Snf2-like helicase family. (PubMed id 9688266)1, 2, 9 Aubry F.... Galibert F. (1998)
    4. Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3. (PubMed id 12505151)1, 2, 9 Lemos T.A.... Kobarg J. (2003)
    5. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. (PubMed id 9804427)1, 2, 9 Tong J.K....Schreiber S.L. (1998)
    6. Chromatin remodeling proteins interact with pericentrin to regulate centrosome integrity. (PubMed id 17626165)1, 2 Sillibourne J.E....Doxsey S.J. (2007)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD. (PubMed id 11230151)1, 2 Schultz D.C.... Rauscher F.J. III (2001)
    9. The C-terminal region of CHD3/ZFH interacts with the CIDD region of the Ets transcription factor ERM and represses transcription of the human presenilin 1 gene. (PubMed id 17489097)1, 9 Pastorcic M. and Das H.K. (2007)
    10. Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules. (PubMed id 14609633)1, 9 Lee B.H....Arikawa J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1107 HGNC: 1918 Ensembl:ENSG00000170004 euGenes: HUgn1107 ECgene: CHD3
    H-InvDB: CHD3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHD3 gene:
    Search GeneIP for patents involving CHD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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