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Aliases for CHD1L Gene

Aliases for CHD1L Gene

  • Chromodomain Helicase DNA Binding Protein 1 Like 2 3 5
  • Amplified In Liver Cancer Protein 1 3 4
  • Amplified In Liver Cancer 1 2 3
  • ALC1 3 4
  • Chromodomain-Helicase-DNA-Binding Protein 1-Like 3
  • EC 3.6.4.12 4
  • EC 3.6.1 61
  • CHDL 3

External Ids for CHD1L Gene

Previous GeneCards Identifiers for CHD1L Gene

  • GC01U990222
  • GC01P143439
  • GC01P144058
  • GC01P144221
  • GC01P143939
  • GC01P145180
  • GC01P146717
  • GC01P120126
  • GC01P147174

Summaries for CHD1L Gene

Entrez Gene Summary for CHD1L Gene

  • This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CHD1L Gene

CHD1L (Chromodomain Helicase DNA Binding Protein 1 Like) is a Protein Coding gene. Diseases associated with CHD1L include Postcholecystectomy Syndrome and Fibrosarcoma Of Bone. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Chromatin Regulation / Acetylation. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for CHD1L Gene

  • DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.

Gene Wiki entry for CHD1L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD1L Gene

Genomics for CHD1L Gene

Regulatory Elements for CHD1L Gene

Enhancers for CHD1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F147241 0.6 ENCODE 20.8 +1.1 1057 3.7 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 CHD1L FMO5 PIR58040
GH01F147272 0.9 Ensembl ENCODE 19.1 +31.5 31491 2.7 CTCF JUN MAX RAD21 FOXK2 SMC3 NFE2 FOS STAT1 ZNF654 ENSG00000237188 CHD1L FMO5 PDIA3P1 PRKAB2 PIR61684 PIR40868
GH01F147235 0.8 ENCODE 18.6 -4.2 -4218 5.0 PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 FOS PRKAB2 CHD1L FMO5 PDIA3P1 ENSG00000237188 GC01P147224
GH01F147245 0.6 ENCODE 16.2 +3.2 3201 0.2 BCOR CREB3L1 JUN ZMYM3 YBX1 ZNF2 CHAMP1 ZNF121 ZNF316 POLR2A CHD1L FMO5 PIR58040
GH01F147165 0.4 ENCODE 16.2 -72.5 -72534 8.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5 PRKAB2 CHD1L FMO5 ACP6 GC01P147160
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CHD1L on UCSC Golden Path with GeneCards custom track

Promoters for CHD1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000079678 659 2601 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS

Genomic Location for CHD1L Gene

Chromosome:
1
Start:
147,242,641 bp from pter
End:
147,295,766 bp from pter
Size:
53,126 bases
Orientation:
Plus strand

Genomic View for CHD1L Gene

Genes around CHD1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHD1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHD1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHD1L Gene

Proteins for CHD1L Gene

  • Protein details for CHD1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WJ1-CHD1L_HUMAN
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 1-like
    Protein Accession:
    Q86WJ1
    Secondary Accessions:
    • A5YM64
    • B4DDE1
    • B5MDZ7
    • Q53EZ3
    • Q5VXX7
    • Q6DD94
    • Q6PK83
    • Q86XH3
    • Q96HF7
    • Q96SP3
    • Q9BVJ1
    • Q9NVV8

    Protein attributes for CHD1L Gene

    Size:
    897 amino acids
    Molecular mass:
    100984 Da
    Quaternary structure:
    • Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).
    SequenceCaution:
    • Sequence=BAB55248.1; Type=Frameshift; Positions=597; Evidence={ECO:0000305};

    Alternative splice isoforms for CHD1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHD1L Gene

Selected DME Specific Peptides for CHD1L Gene

Q86WJ1:
  • NLTAADTVIF
  • YYKAILM
  • DEMGLGKT
  • DEAHRLK
  • HPYLFDG
  • FLLSTRA
  • LVVDEAH
  • HRVLLFSQMT
  • RAHRIGQ
  • YRGYSYER
  • GDVTHPQA

Post-translational modifications for CHD1L Gene

  • Ubiquitination at Lys 793
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CHD1L (CHD1L)

Domains & Families for CHD1L Gene

Suggested Antigen Peptide Sequences for CHD1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WJ1

UniProtKB/Swiss-Prot:

CHD1L_HUMAN :
  • The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 Macro domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with CHD1L: view

No data available for Gene Families for CHD1L Gene

Function for CHD1L Gene

Molecular function for CHD1L Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.

Enzyme Numbers (IUBMB) for CHD1L Gene

Gene Ontology (GO) - Molecular Function for CHD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IDA 19661379
GO:0003676 nucleic acid binding IEA --
GO:0004003 ATP-dependent DNA helicase activity TAS 19661379
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 19661379
genes like me logo Genes that share ontologies with CHD1L: view
genes like me logo Genes that share phenotypes with CHD1L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHD1L

miRNA for CHD1L Gene

miRTarBase miRNAs that target CHD1L

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHD1L Gene

Localization for CHD1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHD1L Gene

Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHD1L Gene COMPARTMENTS Subcellular localization image for CHD1L gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CHD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19661379
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CHD1L: view

Pathways & Interactions for CHD1L Gene

genes like me logo Genes that share pathways with CHD1L: view

Pathways by source for CHD1L Gene

Gene Ontology (GO) - Biological Process for CHD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
GO:0006281 DNA repair TAS 19661379
GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS --
GO:0006294 nucleotide-excision repair, preincision complex assembly TAS --
GO:0006295 nucleotide-excision repair, DNA incision, 3-to lesion TAS --
genes like me logo Genes that share ontologies with CHD1L: view

No data available for SIGNOR curated interactions for CHD1L Gene

Drugs & Compounds for CHD1L Gene

(3) Drugs for CHD1L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for CHD1L Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with CHD1L: view

Transcripts for CHD1L Gene

Unigene Clusters for CHD1L Gene

Chromodomain helicase DNA binding protein 1-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHD1L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: -
SP12:
SP13:
SP14: - -
SP15:

ExUns: 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CHD1L Gene

GeneLoc Exon Structure for
CHD1L
ECgene alternative splicing isoforms for
CHD1L

Expression for CHD1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHD1L Gene

Protein differential expression in normal tissues from HIPED for CHD1L Gene

This gene is overexpressed in Lymph node (22.5) and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CHD1L Gene



Protein tissue co-expression partners for CHD1L Gene

NURSA nuclear receptor signaling pathways regulating expression of CHD1L Gene:

CHD1L

SOURCE GeneReport for Unigene cluster for CHD1L Gene:

Hs.191164

mRNA Expression by UniProt/SwissProt for CHD1L Gene:

Q86WJ1-CHD1L_HUMAN
Tissue specificity: Frequently overexpressed in hepatomacellular carcinomas.
genes like me logo Genes that share expression patterns with CHD1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CHD1L Gene

Orthologs for CHD1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHD1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHD1L 34 35
  • 99.14 (n)
cow
(Bos Taurus)
Mammalia CHD1L 34 35
  • 90.34 (n)
dog
(Canis familiaris)
Mammalia CHD1L 34 35
  • 88.45 (n)
rat
(Rattus norvegicus)
Mammalia Chd1l 34
  • 86.07 (n)
mouse
(Mus musculus)
Mammalia Chd1l 34 16 35
  • 85.34 (n)
oppossum
(Monodelphis domestica)
Mammalia CHD1L 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHD1L 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHD1L 34 35
  • 72.61 (n)
lizard
(Anolis carolinensis)
Reptilia CHD1L 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii chd1l 34 35
  • 64.05 (n)
zgc56084 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ISW2 35
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G44980 34
  • 51.06 (n)
rice
(Oryza sativa)
Liliopsida Os03g0101700 34
  • 48.15 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToOne
Species where no ortholog for CHD1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHD1L Gene

ENSEMBL:
Gene Tree for CHD1L (if available)
TreeFam:
Gene Tree for CHD1L (if available)

Paralogs for CHD1L Gene

(10) SIMAP similar genes for CHD1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHD1L: view

No data available for Paralogs for CHD1L Gene

Variants for CHD1L Gene

Sequence variations from dbSNP and Humsavar for CHD1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10108178 -- 147,232,893(-) ACTTT(C/T)GGCAC intron-variant
rs10159076 -- 147,265,698(+) CAAAT(G/T)AGATA intron-variant, upstream-variant-2KB
rs1044848 -- 147,201,284(+) AGATA(A/C/G/T)CCCTG intron-variant, reference, missense
rs10453880 -- 147,222,097(+) AGGCA(C/T)GGTGG intron-variant
rs10465879 -- 147,226,102(+) ATTTA(C/T)CTTAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHD1L Gene

Variant ID Type Subtype PubMed ID
dgv327n100 CNV gain 25217958
dgv66e199 CNV deletion 23128226
esv2761299 CNV gain+loss 21179565
esv2761654 CNV loss 21179565
esv3894112 CNV loss 25118596
nsv1003688 CNV gain 25217958
nsv1005055 CNV loss 25217958
nsv1132304 CNV duplication 24896259
nsv437047 CNV loss 16327808
nsv509457 CNV insertion 20534489
nsv510962 OTHER complex 20534489
nsv547676 CNV gain 21841781

Variation tolerance for CHD1L Gene

Residual Variation Intolerance Score: 62.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.20; 92.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHD1L Gene

Human Gene Mutation Database (HGMD)
CHD1L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHD1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD1L Gene

Disorders for CHD1L Gene

MalaCards: The human disease database

(2) MalaCards diseases for CHD1L Gene - From: DISEASES

Disorder Aliases PubMed IDs
postcholecystectomy syndrome
fibrosarcoma of bone
  • fibrosarcoma of the bone
- elite association - COSMIC cancer census association via MalaCards
Search CHD1L in MalaCards View complete list of genes associated with diseases

Relevant External Links for CHD1L

Genetic Association Database (GAD)
CHD1L
Human Genome Epidemiology (HuGE) Navigator
CHD1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHD1L
genes like me logo Genes that share disorders with CHD1L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CHD1L Gene

Publications for CHD1L Gene

  1. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. (PMID: 19661379) Ahel D. … Boulton S.J. (Science 2009) 3 4 22 64
  2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  3. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. (PMID: 18023026) Ma N.-F. … Guan X.-Y. (Hepatology 2008) 3 4 64
  4. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for CHD1L Gene

Sources for CHD1L Gene

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