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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHD1L Gene

protein-coding   GIFtS: 59
GCID: GC01P146717

Chromodomain Helicase DNA Binding Protein 1-Like

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromodomain Helicase DNA Binding Protein 1-Like1 2     Amplified In Liver Cancer 12
ALC12 3 5     Chromodomain-Helicase-DNA-Binding Protein 1-Like2
Amplified In Liver Cancer Protein 12 3     EC 3.6.4.123
CHDL2     EC 3.6.18

External Ids:    HGNC: 19161   Entrez Gene: 95572   Ensembl: ENSG000001317787   OMIM: 6130395   UniProtKB: Q86WJ13   

Export aliases for CHD1L gene to outside databases

Previous GC identifers: GC01U990222 GC01P143439 GC01P144058 GC01P144221 GC01P143939 GC01P145180 GC01P120126


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHD1L Gene:
This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose)
as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants
have been described for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for CHD1L Gene: 
CHD1L (chromodomain helicase DNA binding protein 1-like) is a protein-coding gene. Diseases associated with CHD1L include fibrosarcoma of bone, and postcholecystectomy syndrome. GO annotations related to this gene include ATP-dependent DNA helicase activity and nucleotide binding. An important paralog of this gene is SMARCA5.

UniProtKB/Swiss-Prot: CHD1L_HUMAN, Q86WJ1
Function: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA
damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to
catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon
poly(ADP-ribose)-binding

Gene Wiki entry for CHD1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_167185.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHD1L gene promoter:
         STAT5B   AML1a   MyoD   STAT5A   NF-kappaB   AREB6   Nkx6-1   NF-kappaB2   Msx-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHD1L promoter sequence
   Search SABiosciences Chromatin IP Primers for CHD1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q12   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

CHD1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHD1L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P146717:  view genomic region     (about GC identifiers)

Start:
146,714,291 bp from pter      End:
146,767,443 bp from pter
Size:
53,153 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHD1L_HUMAN, Q86WJ1 (See protein sequence)
Recommended Name: Chromodomain-helicase-DNA-binding protein 1-like  
Size: 897 amino acids; 100984 Da
Subunit: Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated)
Subcellular location: Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by
PARylated PARP1
Sequence caution: Sequence=BAB55248.1; Type=Frameshift; Positions=597;
Secondary accessions: A5YM64 Q53EZ3 Q5VXX7 Q6DD94 Q6PK83 Q86XH3 Q96HF7 Q96SP3 Q9BVJ1 Q9NVV8
Alternative splicing: 4 isoforms:  Q86WJ1-1   Q86WJ1-2   Q86WJ1-3   Q86WJ1-4   

Explore the universe of human proteins at neXtProt for CHD1L: NX_Q86WJ1

Explore proteomics data for CHD1L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86WJ1

  • 4/11 DME Specific Peptides for CHD1L (Q86WJ1) (see all 11)
     DEAHRLK  RAHRIGQ  HPYLFDG  YYKAILM 

    CHD1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHD1L Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001243265.1  NP_001243266.1  NP_001243267.1  NP_004275.4  NP_078844.2  

    ENSEMBL proteins: 
     ENSP00000358262   ENSP00000389031   ENSP00000358263   ENSP00000355100  

    Human Recombinant Protein Products for CHD1L: 
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    Cloud-Clone Corp. Proteins for CHD1L 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    CHD1L for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000330 SNF2_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR002589 A1pp
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q86WJ1

    ProtoNet protein and cluster: Q86WJ1

    3 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB002464 ATP-dependent helicase
    IPB002589 Protein of unknown function Appr-1


    UniProtKB/Swiss-Prot: CHD1L_HUMAN, Q86WJ1
    Domain: The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 Macro domain


    CHD1L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHD1L_HUMAN, Q86WJ1
    Function: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA
    damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to
    catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon
    poly(ADP-ribose)-binding
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IDA19661379
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004003ATP-dependent DNA helicase activity TAS19661379
    GO:0004386helicase activity ----
         
    CHD1L for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Chd1l (no phenotypes)

    CHD1L for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHD1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/800 Interacting proteins for CHD1L (Q86WJ12, 3 ENSP000003582624) via UniProtKB, MINT, STRING, and/or I2D (see all 800)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKDCP785272, 3, ENSP000003134204MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000313420
    API5Q9BZZ52, 3, ENSP000003993414MINT-7945693 I2D: score=1 STRING: ENSP00000399341
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    SUPT16HQ9Y5B92, 3, ENSP000002162974MINT-7947479 I2D: score=1 STRING: ENSP00000216297
    EIF4A1P608422, 3, ENSP000002938314MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000293831
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IMP19661379
    GO:0006281DNA repair TAS19661379
    GO:0006338chromatin remodeling IDA19661379
    GO:0006974response to DNA damage stimulus IDA19661379

    CHD1L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHD1L

    Search CenterWatch for drugs/clinical trials and news about CHD1L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHD1L gene (5 alternative transcripts): 
    NM_001256336.1  NM_001256337.1  NM_001256338.1  NM_004284.4  NM_024568.2  

    Unigene Cluster for CHD1L:

    Chromodomain helicase DNA binding protein 1-like
    Hs.191164  [show with all ESTs]
    Unigene Representative Sequence: NM_004284
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488864 ENST00000369258(uc001epm.4 uc001epn.4 uc010ozo.2 uc010ozp.2 uc009wji.3)
    ENST00000467213(uc010ozq.1 uc009wjg.3) ENST00000492728 ENST00000485113
    ENST00000469625 ENST00000431239(uc009wjh.3) ENST00000369259(uc001epo.4)
    ENST00000361293
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF054177.1 AF537213.1 AK001342.1 AK026183.1 AK027631.1 AK223496.1 AK293157.1 AK297135.1 
    AK298424.1 AK303196.1 AK307400.1 BC001171.1 BC005038.1 BC008649.1 BC043501.1 BC053354.1 
    BC077717.1 CR749729.1 EF560738.1 NR_046070.1 XR_110824.3 

    24/30 DOTS entries (see all 30):

    DT.102839184  DT.445087  DT.99955880  DT.91747138  DT.207954  DT.40286524  DT.100027596  DT.100795921 
    DT.455144  DT.121342654  DT.86848913  DT.100795925  DT.95262341  DT.100001336  DT.102826585  DT.121342596 
    DT.121342748  DT.75119316  DT.91747131  DT.92045039  DT.100027597  DT.100657655  DT.102839182  DT.75195946 

    24/229 AceView cDNA sequences (see all 229):

    BE550268 D17100 AI540539 BG493799 BX110536 N46402 AA907338 AI969160 
    BG231737 AI677643 AA573217 CB119739 BF931260 BF931258 BE894366 AU253905 
    AW151810 BU541900 AK026183 BG059917 AA625991 BQ228993 BG821446 BM829255 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for CHD1L (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ·
    SP1:                                                                                      -                 -           -           -           -     -         
    SP2:                                      -                                               -                 -           -           -           -     -         
    SP3:                                                                                      -                 -     -     -     -     -     -     -     -         
    SP4:                                -     -     -     -     -     -     -     -     -     -                 -           -           -           -     -         
    SP5:                                                                    -                 -                 -           -           -                           

    ExUns: 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24
    SP1:                                                  -                                       
    SP2:                                                  -                                       
    SP3:                                                  -                                       
    SP4:                                                  -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CHD1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHD1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACGAAAGG
    CHD1L Expression
    About this image


    See CHD1L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHD1L

    SOURCE GeneReport for Unigene cluster: Hs.191164

    UniProtKB/Swiss-Prot: CHD1L_HUMAN, Q86WJ1
    Tissue specificity: Frequently overexpressed in hepatomacellular carcinomas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHD1L gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chd1l1 , 5 chromodomain helicase DNA binding protein 1-like1, 5 85.34(n)1
    87.64(a)1
      3 (42.17 cM)5
    680581  NM_026539.21  NP_080815.11 
     975607485 
    chicken
    (Gallus gallus)
    Aves CHD1L1 chromodomain helicase DNA binding protein 1-like 72.41(n)
    72.95(a)
      418338  XM_416560.3  XP_416560.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHD1L6
    chromodomain helicase DNA binding protein 1-like
    68(a)
    1 ↔ 1
    2(82699886-82747244)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560842 similar to chromodomain helicase DNA binding protein more 74.92(n)   393283  BC050498.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ISW16
    Member of the imitation-switch (ISWI) class of ATP...
    25(a)
    1 ↔ 1
    II(708150-711539)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G449801 SNF2 and helicase domain-containing protein 51.15(n)
    44.9(a)
      819106  NM_201960.2  NP_973689.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g01017001 hypothetical protein 47.84(n)
    41.18(a)
      4331290  NM_001055191.1  NP_001048656.1 


    ENSEMBL Gene Tree for CHD1L (if available)
    TreeFam Gene Tree for CHD1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHD1L gene
    SMARCA52  SMARCA12  
    10 SIMAP similar genes for CHD1L using alignment to 2 protein entries:     CHD1L_HUMAN (see all proteins):
    SMARCA5    CHD5    CHD8    CHD9    CHD4    CHD2
    CHD3    HELLS    SMARCA1    SMARCA4

    CHD1L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1305 SNPs in CHD1L are shown (see all 1305)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0429544
    ----see VAR_0429542 R P mis40--------
    rs726910151,2
    C--146716857(+) AGACCC/GCACTG 6 -- int14Minor allele frequency- G:0.28CSA WA NA EA 360
    rs594027041,2
    C,F--146716962(+) TTTTCC/TGCTTC 6 -- int12Minor allele frequency- T:0.07WA 120
    rs1895168581,2
    --146716976(+) CTTAGC/GTACTA 6 -- int10--------
    rs120920161,2
    C--146716994(+) GGTCTC/GTGGGA 6 -- int18Minor allele frequency- G:0.22NA WA EA 368
    rs726910161,2
    C,F--146717027(+) TATCAT/CGGATT 6 -- int13Minor allele frequency- C:0.15WA NA EA 358
    rs1162790061,2
    C--146717213(+) TTGTGG/ATGATC 6 -- int11Minor allele frequency- A:0.01WA 118
    rs799821931,2
    C,F--146717254(+) AACCTA/GCCAAG 6 -- int11Minor allele frequency- G:0.23EA 120
    rs1431548251,2
    C--146717261(+) CAAGGA/GTAATT 6 -- int10--------
    rs113505391,2
    C--146717349(+) TCAAC-/TTTTTT 6 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for CHD1L (146714291 - 146767443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CHD1L:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717529CNV Deletion23290073
    dgv354n71CNV Loss21882294
    dgv355n71CNV Loss21882294
    nsv437047CNV Loss16327808
    nsv872259CNV Loss21882294
    nsv872257CNV Gain21882294
    nsv872255CNV Gain21882294
    nsv872251CNV Gain21882294
    nsv7181OTHER Inversion18451855


    Human Gene Mutation Database (HGMD): CHD1L
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHD1L
    DNA2.0 Custom Variant and Variant Library Synthesis for CHD1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613039    OMIM disorders: --

    12 diseases for CHD1L:    About MalaCards
    fibrosarcoma of bone    postcholecystectomy syndrome    choanal atresia    fibrosarcoma
    hypercholesterolemia    esophageal adenocarcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    pneumonia    hepatocellular carcinoma    esophagitis    adenocarcinoma


    CHD1L for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHD1L
    Human Genome Epidemiology (HuGE) Navigator: CHD1L (1 document)

    Export disorders for CHD1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHD1L gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with CHD1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. (PubMed id 19661379)1, 2, 9 Ahel D....Boulton S.J. (2009)
    2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    3. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. (PubMed id 18023026)1, 2 Ma N.-F.... Guan X.-Y. (2008)
    4. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 3 Mao M.... Chen Z. (1998)
    7. Activation of the SNF2 family ATPase ALC1 by poly(ADP- ribose) in a stable ALC1^PARP1^nucleosome intermediate. (PubMed id 23132853)1 Gottschalk A.J....Conaway R.C. (2012)
    8. CHD1L: a new candidate gene for congenital anomalies o f the kidneys and urinary tract (CAKUT). (PubMed id 22146311)1 Brockschmidt A....Weber R.G. (2012)
    9. PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1. (PubMed id 23045548)1 Pines A....Mullenders L. (2012)
    10. CHD1L protein is overexpressed in human ovarian carcin omas and is a novel predictive biomarker for patients survival. (PubMed id 23020525)1 He W.P....Yang G.F. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9557 HGNC: 1916 AceView: CHD1L Ensembl:ENSG00000131778 euGenes: HUgn9557
    ECgene: CHD1L H-InvDB: CHD1L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHD1L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHD1L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHD1L gene:
    Search GeneIP for patents involving CHD1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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