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Aliases for CHD1L Gene

Aliases for CHD1L Gene

  • Chromodomain Helicase DNA Binding Protein 1-Like 2 3
  • ALC1 3 4 6
  • Amplified In Liver Cancer Protein 1 3 4
  • Amplified In Liver Cancer 1 2 3
  • Chromodomain-Helicase-DNA-Binding Protein 1-Like 3
  • EC 3.6.4.12 4
  • EC 3.6.1 63
  • CHDL 3

External Ids for CHD1L Gene

Previous GeneCards Identifiers for CHD1L Gene

  • GC01U990222
  • GC01P143439
  • GC01P144058
  • GC01P144221
  • GC01P143939
  • GC01P145180
  • GC01P146717
  • GC01P120126

Summaries for CHD1L Gene

Entrez Gene Summary for CHD1L Gene

  • This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants have been described for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CHD1L Gene

CHD1L (Chromodomain Helicase DNA Binding Protein 1-Like) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and ATP-dependent DNA helicase activity. An important paralog of this gene is SMARCA1.

UniProtKB/Swiss-Prot for CHD1L Gene

  • DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.

Gene Wiki entry for CHD1L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHD1L Gene

Genomics for CHD1L Gene

Regulatory Elements for CHD1L Gene

Genomic Location for CHD1L Gene

Start:
147,172,804 bp from pter
End:
147,295,766 bp from pter
Size:
122,963 bases
Orientation:
Plus strand

Genomic View for CHD1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHD1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHD1L Gene

Proteins for CHD1L Gene

  • Protein details for CHD1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WJ1-CHD1L_HUMAN
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 1-like
    Protein Accession:
    Q86WJ1
    Secondary Accessions:
    • A5YM64
    • B4DDE1
    • B5MDZ7
    • Q53EZ3
    • Q5VXX7
    • Q6DD94
    • Q6PK83
    • Q86XH3
    • Q96HF7
    • Q96SP3
    • Q9BVJ1
    • Q9NVV8

    Protein attributes for CHD1L Gene

    Size:
    897 amino acids
    Molecular mass:
    100984 Da
    Quaternary structure:
    • Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated).
    SequenceCaution:
    • Sequence=BAB55248.1; Type=Frameshift; Positions=597; Evidence={ECO:0000305};

    Alternative splice isoforms for CHD1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHD1L Gene

Proteomics data for CHD1L Gene at MOPED

Post-translational modifications for CHD1L Gene

  • Ubiquitination at Lys793
  • Modification sites at PhosphoSitePlus

Domains for CHD1L Gene

Suggested Antigen Peptide Sequences for CHD1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WJ1

UniProtKB/Swiss-Prot:

CHD1L_HUMAN :
  • Q86WJ1
Domain:
  • The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 Macro domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with CHD1L: view

No data available for Gene Families for CHD1L Gene

Function for CHD1L Gene

Molecular function for CHD1L Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot Function: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.

Enzyme Numbers (IUBMB) for CHD1L Gene

Gene Ontology (GO) - Molecular Function for CHD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IDA 19661379
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0004003 ATP-dependent DNA helicase activity TAS 19661379
GO:0005515 protein binding IPI 19661379
genes like me logo Genes that share ontologies with CHD1L: view

miRNA for CHD1L Gene

miRTarBase miRNAs that target CHD1L

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHD1L Gene

Localization for CHD1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHD1L Gene

Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHD1L Gene COMPARTMENTS Subcellular localization image for CHD1L gene
Compartment Confidence
nucleus 5
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for CHD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19661379
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with CHD1L: view

Pathways for CHD1L Gene

SuperPathways for CHD1L Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHD1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006281 DNA repair TAS 19661379
GO:0006338 chromatin remodeling IDA 19661379
GO:0006974 cellular response to DNA damage stimulus IDA 19661379
GO:0032508 DNA duplex unwinding TAS 19661379
genes like me logo Genes that share ontologies with CHD1L: view

No data available for Pathways by source for CHD1L Gene

Transcripts for CHD1L Gene

Unigene Clusters for CHD1L Gene

Chromodomain helicase DNA binding protein 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHD1L Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ·
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - - - - -
SP6: - - - - - -
SP7: - - - - - - - -
SP8: -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: -
SP12:
SP13:
SP14: - -
SP15:

ExUns: 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1: -
SP2: -
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for CHD1L Gene

GeneLoc Exon Structure for
CHD1L
ECgene alternative splicing isoforms for
CHD1L

Expression for CHD1L Gene

mRNA expression in normal human tissues for CHD1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHD1L Gene

SOURCE GeneReport for Unigene cluster for CHD1L Gene Hs.191164

mRNA Expression by UniProt/SwissProt for CHD1L Gene

Q86WJ1-CHD1L_HUMAN
Tissue specificity: Frequently overexpressed in hepatomacellular carcinomas.
genes like me logo Genes that share expressions with CHD1L: view

No data available for mRNA differential expression in normal tissues for CHD1L Gene

Orthologs for CHD1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHD1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHD1L 35
  • 99.14 (n)
  • 99 (a)
CHD1L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHD1L 35
  • 90.34 (n)
  • 91.61 (a)
CHD1L 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHD1L 35
  • 88.45 (n)
  • 88.04 (a)
CHD1L 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chd1l 35
  • 85.34 (n)
  • 87.64 (a)
Chd1l 16
Chd1l 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHD1L 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHD1L 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chd1l 35
  • 86.07 (n)
  • 88.18 (a)
chicken
(Gallus gallus)
Aves CHD1L 35
  • 72.61 (n)
  • 73.45 (a)
CHD1L 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHD1L 36
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii chd1l 35
  • 64.05 (n)
  • 66.51 (a)
chd1l 36
  • 55 (a)
OneToOne
zgc56084 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ISW2 36
  • 23 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G44980 35
  • 51.06 (n)
  • 44.9 (a)
rice
(Oryza sativa)
Liliopsida Os03g0101700 35
  • 48.15 (n)
  • 41.44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToOne
Species with no ortholog for CHD1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHD1L Gene

ENSEMBL:
Gene Tree for CHD1L (if available)
TreeFam:
Gene Tree for CHD1L (if available)

Paralogs for CHD1L Gene

Paralogs for CHD1L Gene

Selected SIMAP similar genes for CHD1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHD1L: view

Variants for CHD1L Gene

Sequence variations from dbSNP and Humsavar for CHD1L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2452 -- 147,281,706(-) ATTAA(A/G)AAGCC intron-variant
rs6537 -- 147,295,639(-) CCAAA(C/T)TGAAA utr-variant-3-prime
rs6538 -- 147,295,672(-) AGGTA(C/T)CAAAA utr-variant-3-prime, nc-transcript-variant
rs720609 -- 147,181,448(-) CAATC(A/G)AAAGA intron-variant
rs953087 -- 147,267,881(+) GATAA(G/T)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHD1L Gene

Variant ID Type Subtype PubMed ID
nsv7181 OTHER Inversion 18451855
nsv872251 CNV Gain 21882294
nsv872255 CNV Gain 21882294
nsv872257 CNV Gain 21882294
nsv437047 CNV Loss 16327808
nsv872259 CNV Loss 21882294
esv2717529 CNV Deletion 23290073
dgv354n71 CNV Loss 21882294
dgv355n71 CNV Loss 21882294

Relevant External Links for CHD1L Gene

HapMap Linkage Disequilibrium report
CHD1L
Human Gene Mutation Database (HGMD)
CHD1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHD1L Gene

Disorders for CHD1L Gene

Relevant External Links for CHD1L

Genetic Association Database (GAD)
CHD1L
Human Genome Epidemiology (HuGE) Navigator
CHD1L
genes like me logo Genes that share disorders with CHD1L: view

No data available for UniProtKB/Swiss-Prot for CHD1L Gene

Publications for CHD1L Gene

  1. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. (PMID: 19661379) Ahel D. … Boulton S.J. (Science 2009) 3 4 23
  2. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. (PMID: 18023026) Ma N.-F. … Guan X.-Y. (Hepatology 2008) 3 4
  3. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PMID: 18464913) Melzer D. … Ferrucci L. (PLoS Genet. 2008) 3 48
  4. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for CHD1L Gene

Sources for CHD1L Gene

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