Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CHD1L Gene

protein-coding   GIFtS: 61
GCID: GC01P146717

Chromodomain Helicase DNA Binding Protein 1-Like

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chromodomain Helicase DNA Binding Protein 1-Like1 2     Amplified In Liver Cancer 12
ALC12 3 5     Chromodomain-Helicase-DNA-Binding Protein 1-Like2
Amplified In Liver Cancer Protein 12 3     EC 3.6.4.123
CHDL2     EC 3.6.18

External Ids:    HGNC: 19161   Entrez Gene: 95572   Ensembl: ENSG000001317787   OMIM: 6130395   UniProtKB: Q86WJ13   

Export aliases for CHD1L gene to outside databases

Previous GC identifers: GC01U990222 GC01P143439 GC01P144058 GC01P144221 GC01P143939 GC01P145180 GC01P120126


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CHD1L Gene:
This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose)
as it regulates chromatin relaxation following DNA damage. Several alternatively spliced transcripts variants
have been described for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for CHD1L Gene:
CHD1L (chromodomain helicase DNA binding protein 1-like) is a protein-coding gene. GO annotations related to this gene include ATP-dependent DNA helicase activity and nucleotide binding. An important paralog of this gene is SMARCA5.

UniProtKB/Swiss-Prot: CHD1L_HUMAN, Q86WJ1
Function: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA
damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to
catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon
poly(ADP-ribose)-binding

Gene Wiki entry for CHD1L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHD1L gene promoter:
         STAT5B   AML1a   MyoD   STAT5A   NF-kappaB   AREB6   Nkx6-1   NF-kappaB2   Msx-1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHD1L promoter sequence
   Search Chromatin IP Primers for CHD1L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHD1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q12   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

CHD1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHD1L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P146717:  view genomic region     (about GC identifiers)

Start:
146,714,291 bp from pter      End:
146,767,443 bp from pter
Size:
53,153 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CHD1L_HUMAN, Q86WJ1 (See protein sequence)
Recommended Name: Chromodomain-helicase-DNA-binding protein 1-like  
Size: 897 amino acids; 100984 Da
Subunit: Interacts with PARP1; interacts only when PARP1 is poly-ADP-ribosylated (PARylated)
Sequence caution: Sequence=BAB55248.1; Type=Frameshift; Positions=597;
Secondary accessions: A5YM64 Q53EZ3 Q5VXX7 Q6DD94 Q6PK83 Q86XH3 Q96HF7 Q96SP3 Q9BVJ1 Q9NVV8
Alternative splicing: 4 isoforms:  Q86WJ1-1   Q86WJ1-2   Q86WJ1-3   Q86WJ1-4   

Explore the universe of human proteins at neXtProt for CHD1L: NX_Q86WJ1

Explore proteomics data for CHD1L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys793
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CHD1L (Q86WJ1) (see all 11)
     DEAHRLK  RAHRIGQ  HPYLFDG  YYKAILM 


    See CHD1L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001243265.1  NP_001243266.1  NP_001243267.1  NP_004275.4  NP_078844.2  

    ENSEMBL proteins: 
     ENSP00000358262   ENSP00000389031   ENSP00000358263   ENSP00000355100  

    CHD1L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CHD1L
    OriGene Protein Over-expression Lysate for CHD1L
    OriGene MassSpec for CHD1L
    OriGene Custom Protein Services for CHD1L
    GenScript Custom Purified and Recombinant Proteins Services for CHD1L
    Novus Biologicals CHD1L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHD1L

     
    Search eBioscience for Proteins for CHD1L 

    CHD1L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CHD1L
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHD1L
    Novus Biologicals CHD1L Antibodies
    Abcam antibodies for CHD1L
    Cloud-Clone Corp. Antibodies for CHD1L
    ThermoFisher Antibodies for CHD1L
    LSBio Antibodies in human, mouse, rat for CHD1L

    CHD1L Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHD1L
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHD1L
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHD1L
    Cloud-Clone Corp. CLIAs for CHD1L
    Search eBioscience for ELISAs for CHD1L 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    Selected InterPro protein domains (see all 6):
     IPR000330 SNF2_N
     IPR002464 DNA/RNA_helicase_DEAH_CS
     IPR002589 Macro_dom
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd

    Graphical View of Domain Structure for InterPro Entry Q86WJ1

    ProtoNet protein and cluster: Q86WJ1

    3 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB002464 ATP-dependent helicase
    IPB002589 Protein of unknown function Appr-1


    UniProtKB/Swiss-Prot: CHD1L_HUMAN, Q86WJ1
    Domain: The macro domain mediates non-covalent poly(ADP-ribose)-binding and recruitment to DNA damage sites
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain
    Similarity: Contains 1 Macro domain


    Find genes that share domains with CHD1L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHD1L_HUMAN, Q86WJ1
    Function: DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA
    damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to
    catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon
    poly(ADP-ribose)-binding
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IDA19661379
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004003ATP-dependent DNA helicase activity TAS19661379
    GO:0004386helicase activity ----
         
    Find genes that share ontologies with CHD1L           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Chd1l (no phenotypes)

    Find genes that share phenotypes with CHD1L           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHD1L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHD1L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHD1L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHD1L

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHD1L:
    hsa-mir-320a (MIRT044802)

    Block miRNA regulation of human, mouse, rat CHD1L using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CHD1L
    SwitchGear 3'UTR luciferase reporter plasmidCHD1L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHD1L
    Predesigned siRNA for gene silencing in human, mouse, rat CHD1L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHD1L

    Clone
    Products:
         
    OriGene clones in human, mouse for CHD1L (see all 7)
    OriGene ORF clones in mouse, rat for CHD1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHD1L (NM_004284)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHD1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHD1L
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHD1L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CHD1L_HUMAN, Q86WJ1: Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by
    PARylated PARP1
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane4
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with CHD1L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHD1L
    Interactions:

        Search GeneGlobe Interaction Network for CHD1L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHD1L (Q86WJ12, 3 ENSP000003582624) via UniProtKB, MINT, STRING, and/or I2D (see all 823)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKDCP785272, 3, ENSP000003134204MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000313420
    API5Q9BZZ52, 3, ENSP000003993414MINT-7945693 I2D: score=1 STRING: ENSP00000399341
    PARP1P098742, 3, ENSP000003557594MINT-7947479 I2D: score=1 STRING: ENSP00000355759
    SUPT16HQ9Y5B92, 3, ENSP000002162974MINT-7947479 I2D: score=1 STRING: ENSP00000216297
    EIF4A1P608422, 3, ENSP000002938314MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000293831
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IMP19661379
    GO:0006281DNA repair TAS19661379
    GO:0006338chromatin remodeling IDA19661379
    GO:0006974cellular response to DNA damage stimulus IDA19661379
    GO:0032508DNA duplex unwinding TAS19661379

    Find genes that share ontologies with CHD1L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHD1L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CHD1L gene (5 alternative transcripts): 
    NM_001256336.1  NM_001256337.1  NM_001256338.1  NM_004284.4  NM_024568.2  

    Unigene Cluster for CHD1L:

    Chromodomain helicase DNA binding protein 1-like
    Hs.191164  [show with all ESTs]
    Unigene Representative Sequence: NM_004284
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488864 ENST00000369258(uc001epm.4 uc001epn.4 uc010ozo.2 uc010ozp.2 uc009wji.3)
    ENST00000467213(uc010ozq.1 uc009wjg.3) ENST00000492728 ENST00000485113
    ENST00000469625 ENST00000431239(uc009wjh.3) ENST00000369259(uc001epo.4)
    ENST00000361293
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHD1L using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CHD1L
    SwitchGear 3'UTR luciferase reporter plasmidCHD1L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHD1L
    Predesigned siRNA for gene silencing in human, mouse, rat CHD1L
    Clone
    Products:
         
    OriGene clones in human, mouse for CHD1L (see all 7)
    OriGene ORF clones in mouse, rat for CHD1L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHD1L (NM_004284)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHD1L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1L
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CHD1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHD1L
      QuantiTect SYBR Green Assays in human, mouse, rat CHD1L
      QuantiFast Probe-based Assays in human, mouse, rat CHD1L

    Additional mRNA sequence: 

    AF054177.1 AF537213.1 AK001342.1 AK026183.1 AK027631.1 AK223496.1 AK293157.1 AK297135.1 
    AK298424.1 AK303196.1 AK307400.1 BC001171.1 BC005038.1 BC008649.1 BC043501.1 BC053354.1 
    BC077717.1 CR749729.1 EF560738.1 NR_046070.1 XR_110824.3 

    Selected DOTS entries (see all 30):

    DT.102839184  DT.445087  DT.99955880  DT.91747138  DT.207954  DT.40286524  DT.100027596  DT.100795921 
    DT.455144  DT.121342654  DT.86848913  DT.100795925  DT.95262341  DT.100001336  DT.102826585  DT.121342596 
    DT.121342748  DT.75119316  DT.91747131  DT.92045039  DT.100027597  DT.100657655  DT.102839182  DT.75195946 

    Selected AceView cDNA sequences (see all 229):

    BG231737 AA573217 AA907338 BF931258 AI540539 BE894366 BE550268 BX110536 
    BG493799 CB119739 AI969160 BF931260 D17100 AI677643 N46402 BQ575755 
    AV648029 AA886210 BM750732 AL601649 BU541900 AU253905 BF683919 BV179710 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CHD1L (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14a · 14b ·
    SP1:                                                                                      -                 -           -           -           -     -         
    SP2:                                      -                                               -                 -           -           -           -     -         
    SP3:                                                                                      -                 -     -     -     -     -     -     -     -         
    SP4:                                -     -     -     -     -     -     -     -     -     -                 -           -           -           -     -         
    SP5:                                                                    -                 -                 -           -           -                           

    ExUns: 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23a · 23b ^ 24
    SP1:                                                  -                                       
    SP2:                                                  -                                       
    SP3:                                                  -                                       
    SP4:                                                  -                                       
    SP5:                                                                                          


    ECgene alternative splicing isoforms for CHD1L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CHD1L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCACGAAAGG
    CHD1L Expression
    About this image


    CHD1L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CHD1L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHD1L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191164

    UniProtKB/Swiss-Prot: CHD1L_HUMAN, Q86WJ1
    Tissue specificity: Frequently overexpressed in hepatomacellular carcinomas

        Custom PCR Arrays for CHD1L
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CHD1L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHD1L
    QuantiTect SYBR Green Assays in human, mouse, rat CHD1L
    QuantiFast Probe-based Assays in human, mouse, rat CHD1L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHD1L gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chd1l1 , 5 chromodomain helicase DNA binding protein 1-like1, 5 85.34(n)1
    87.64(a)1
      3 (42.17 cM)5
    680581  NM_026539.21  NP_080815.11 
     975607485 
    chicken
    (Gallus gallus)
    Aves CHD1L1 chromodomain helicase DNA binding protein 1-like 72.61(n)
    73.45(a)
      418338  XM_004938192.1  XP_004938249.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHD1L6
    chromodomain helicase DNA binding protein 1-like
    67(a)
    1 ↔ 1
    2(82699886-82747244)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc560842 similar to chromodomain helicase DNA binding protein more 74.92(n)   393283  BC050498.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ISW26
    ATP-dependent DNA translocase involved in chromati...
    23(a)
    1 → many
    XV(884514-887876) YOR304W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G449801 AT2G44980 51.06(n)
    44.9(a)
      819106  NM_201960.2  NP_973689.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g01017001 Os03g0101700 48.15(n)
    41.44(a)
      4331290  NM_001055191.1  NP_001048656.1 


    ENSEMBL Gene Tree for CHD1L (if available)
    TreeFam Gene Tree for CHD1L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CHD1L gene
    SMARCA52  SMARCA12  
    10 SIMAP similar genes for CHD1L using alignment to 2 protein entries:     CHD1L_HUMAN (see all proteins):
    SMARCA5    CHD5    CHD8    CHD9    CHD4    CHD2
    CHD3    HELLS    SMARCA1    SMARCA4

    Find genes that share paralogs with CHD1L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CHD1L (see all 1305)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs726910151,2
    C--146716857(+) AGACCC/GCACTG 6 -- int14Minor allele frequency- G:0.28CSA WA NA EA 360
    rs594027041,2
    C,F--146716962(+) TTTTCC/TGCTTC 6 -- int12Minor allele frequency- T:0.07WA 120
    rs1895168581,2
    --146716976(+) CTTAGC/GTACTA 6 -- int10--------
    rs120920161,2
    C--146716994(+) GGTCTC/GTGGGA 6 -- int18Minor allele frequency- G:0.22NA WA EA 368
    rs726910161,2
    C,F--146717027(+) TATCAT/CGGATT 6 -- int13Minor allele frequency- C:0.15WA NA EA 358
    rs1162790061,2
    C--146717213(+) TTGTGG/ATGATC 6 -- int11Minor allele frequency- A:0.01WA 118
    rs799821931,2
    C,F--146717254(+) AACCTA/GCCAAG 6 -- int11Minor allele frequency- G:0.23EA 120
    rs1431548251,2
    C--146717261(+) CAAGGA/GTAATT 6 -- int10--------
    rs113505391,2
    C--146717349(+) TCAAC-/TTTTTT 6 -- int1 trp30--------
    rs49503901,2
    C,F,A--146717370(+) AGATAG/AGGTCT 6 -- int18Minor allele frequency- A:0.42NA WA CSA EA 251

    HapMap Linkage Disequilibrium report for CHD1L (146714291 - 146767443 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CHD1L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717529CNV Deletion23290073
    dgv354n71CNV Loss21882294
    dgv355n71CNV Loss21882294
    nsv437047CNV Loss16327808
    nsv872259CNV Loss21882294
    nsv872257CNV Gain21882294
    nsv872255CNV Gain21882294
    nsv872251CNV Gain21882294
    nsv7181OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): CHD1L
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHD1L
    DNA2.0 Custom Variant and Variant Library Synthesis for CHD1L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613039    OMIM disorders: --


    Find genes that share disorders with CHD1L           About GenesLikeMe

    Genetic Association Database (GAD): CHD1L
    Human Genome Epidemiology (HuGE) Navigator: CHD1L (1 document)

    Export disorders for CHD1L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CHD1L gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with CHD1L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. (PubMed id 19661379)1, 2, 9 Ahel D....Boulton S.J. (Science 2009)
    2. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)
    3. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. (PubMed id 18023026)1, 2 Ma N.-F.... Guan X.-Y. (Hepatology 2008)
    4. A genome-wide association study identifies protein quantitative trait loci (pQTLs). (PubMed id 18464913)1, 4 Melzer D....Ferrucci L. (PLoS Genet. 2008)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 3 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    7. Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein. (PubMed id 23926104)1 Kulkarni A....Ganesan S. (J. Biol. Chem. 2013)
    8. CHD1L promotes tumor progression and predicts survival in colorectal carcinoma. (PubMed id 23746766)1 Ji X....Zhu Z. (J. Surg. Res. 2013)
    9. Expression of CHD1L in bladder cancer and its influence on prognosis and survival. (PubMed id 23807680)1 Tian F....Cheng W. (Tumour Biol. 2013)
    10. Activation of the SNF2 family ATPase ALC1 by poly(ADP-ribose) in a stable ALC1A^PARP1A^nucleosome intermediate. (PubMed id 23132853)1 Gottschalk A.J....Conaway R.C. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9557 HGNC: 1916 AceView: CHD1L Ensembl:ENSG00000131778 euGenes: HUgn9557
    ECgene: CHD1L H-InvDB: CHD1L

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CHD1L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHD1L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CHD1L gene:
    Search GeneIP for patents involving CHD1L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CHD1L (CHD1L)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHD1L  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CHD1L  
     OriGene MassSpec something-or-other for CHD1L   OriGene clones in human, mouse for CHD1L  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHD1L   OriGene Purified Protein for CHD1L  
     OriGene ORF clones in mouse, rat for CHD1L   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHD1L   OriGene Custom Protein Services for CHD1L  

     
     
     Block miRNA regulation of human, mouse, rat CHD1L using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CHD1L
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHD1L Predesigned siRNA for gene silencing in human, mouse, rat CHD1L
     QuantiFast Probe-based Assays in human, mouse, rat CHD1L QuantiTect SYBR Green Assays in human, mouse, rat CHD1L
     Custom PCR Arrays for CHD1L Search Chromatin IP Primers for CHD1L
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHD1L  Search GeneGlobe Interaction Network for CHD1L
     Regulatory tfbs in CHD1L promoter
     GenScript Custom Purified and Recombinant Proteins Services for CHD1L GenScript cDNA clones with any tag delivered in your preferred vector for CHD1L
     GenScript Custom Assay Services for CHD1L GenScript Custom overexpressing Cell Line Services for CHD1L
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CHD1L
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CHD1L antibodies
     CHD1L lysates
     Antibodies for CHD1L
     See all of Abcam's Antibodies, Kits and Proteins for CHD1L
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CHD1L
     Antibodies for CHD1L
     ELISAs for CHD1L
     CLIAs for CHD1L



     Browse ESI BIO Cell Lines and PureStem Progenitors for CHD1L
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1L
     SwitchGear 3'UTR luciferase reporter plasmids for CHD1L
     SwitchGear Promoter luciferase reporter plasmids for CHD1L
     ThermoFisher Antibodies for CHD1L
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1L
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHD1L
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHD1L
     LSBio Antibodies in human, mouse, rat for CHD1L
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CHD1L
      Search eBioscience for proteins for CHD1L
      Search eBioscience for elisas for CHD1L
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHD1L gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4