Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHD1 Gene

protein-coding   GIFtS: 64
GCID: GC05M098219

Chromodomain Helicase DNA Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromodomain Helicase DNA Binding Protein 11 2
CHD-12 3
ATP-Dependent Helicase CHD12 3
Chromodomain-Helicase-DNA-Binding Protein 12
EC 3.6.4.123
EC 3.6.18

External Ids:    HGNC: 19151   Entrez Gene: 11052   Ensembl: ENSG000001539227   OMIM: 6021185   UniProtKB: O146463   

Export aliases for CHD1 gene to outside databases

Previous GC identifers: GC05M097537 GC05M098601 GC05M098222 GC05M098267 GC05M093378


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHD1 Gene:
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains
and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin
structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CHD1 Gene: 
CHD1 (chromodomain helicase DNA binding protein 1) is a protein-coding gene. Diseases associated with CHD1 include cystic echinococcosis, and periventricular nodular heterotopia. GO annotations related to this gene include ATP-dependent DNA helicase activity and methylated histone residue binding. An important paralog of this gene is CHD6.

UniProtKB/Swiss-Prot: CHD1_HUMAN, O14646
Function: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the
transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also
required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription
termination step. Regulates negatively DNA replication. Not only involved in transcription-related
chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also
associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT
complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of
pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for
maintaining open chromatin and pluripotency in embryonic stem cells

Gene Wiki entry for CHD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_034772.6  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHD1 gene promoter:
         TBP   PPAR-gamma1   AML1a   POU3F1   HTF   PPAR-gamma2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q15-q21   Ensembl cytogenetic band:  5q21.1   HGNC cytogenetic band: 5q15-q21

CHD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHD1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M098219:  view genomic region     (about GC identifiers)

Start:
98,190,908 bp from pter      End:
98,262,240 bp from pter
Size:
71,333 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHD1_HUMAN, O14646 (See protein sequence)
Recommended Name: Chromodomain-helicase-DNA-binding protein 1  
Size: 1710 amino acids; 196688 Da
Subunit: Component of the SAGA complex (By similarity). Interacts with BCLAF1, NCoR, SRP20 and SAFB (By
similarity). Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF
complex and the U2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Is released into the cytoplasm when cells enter
mitosis and is reincorporated into chromatin during telophase-cytokinesis (By similarity)
6 PDB 3D structures from and Proteopedia for CHD1:
2B2T (3D)        2B2U (3D)        2B2V (3D)        2B2W (3D)        2B2Y (3D)        4B4C (3D)    
Secondary accessions: Q17RZ3
Alternative splicing: 2 isoforms:  O14646-1   O14646-2   

Explore the universe of human proteins at neXtProt for CHD1: NX_O14646

Explore proteomics data for CHD1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14646

  • 4/14 DME Specific Peptides for CHD1 (O14646) (see all 14)
     DEAHRLK  RAHRIGQ  TGTPLQN  ERMRPVK 

    CHD1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHD1 Protein Expression
    REFSEQ proteins: NP_001261.2  
    ENSEMBL proteins: 
     ENSP00000284049   ENSP00000422589   ENSP00000422225  

    Human Recombinant Protein Products for CHD1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CHD1
    GenScript Custom Purified and Recombinant Proteins Services for CHD1
    Novus Biologicals CHD1 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHD1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    CHD1 for ontologies           About GeneDecksing



    CHD1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CHD1
    R&D Systems Antibodies for CHD1
    Cell Signaling Technology (CST) Antibodies for CHD1  (CHD-1)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHD1
    GenScript Custom Superior Antibodies Services for CHD1
    Novus Biologicals CHD1 Antibodies
    Abcam antibodies for CHD1
    Cloud-Clone Corp. Antibodies for CHD1 
    Search ThermoFisher Antibodies for CHD1
    LSBio Antibodies in human, mouse, rat for CHD1 

    Assay Products for CHD1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHD1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHD1 
    Cloud-Clone Corp. CLIAs for CHD1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR000953 Chromo_domain/shadow
     IPR000330 SNF2_N
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS

    Graphical View of Domain Structure for InterPro Entry O14646

    ProtoNet protein and cluster: O14646

    4 Blocks protein domains:
    IPB000330 SNF2 related domain
    IPB000953 Chromo domain
    IPB001005 Myb DNA-binding domain
    IPB002464 ATP-dependent helicase


    UniProtKB/Swiss-Prot: CHD1_HUMAN, O14646
    Domain: The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3)
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 2 chromo domains
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    CHD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CHD1_HUMAN, O14646
    Function: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the
    transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also
    required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription
    termination step. Regulates negatively DNA replication. Not only involved in transcription-related
    chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also
    associated with histone deacetylase (HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT
    complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of
    pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for
    maintaining open chromatin and pluripotency in embryonic stem cells
    Catalytic activity: ATP + H(2)O = ADP + phosphate

         Genatlas biochemistry entry for CHD1:
    DNA binding protein with two chromatin organization (chromo) domains and a helicase ATPase domain,1,binding A.T
    tracts, released into cytoplasm during mitosis,component of the chromatin remodeling complex

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0004003ATP-dependent DNA helicase activity TAS9326634
    GO:0004386helicase activity ----
    GO:0005515protein binding IPI--
         
    CHD1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CHD1:
     Synthetic lethal with c-Myc af  Wnt reporter downregulated 

         1 MGI phenotypic allele for Chd1 (no phenotypes)

    CHD1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHD1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHD1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHD1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHD1:
    hsa-mir-30a (MIRT005127)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHD1
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate CHD1 (see all 68):
    hsa-miR-100* hsa-miR-4272 hsa-miR-30d hsa-miR-4275 hsa-miR-30a hsa-miR-489 hsa-miR-3613-3p hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidCHD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHD1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHD1
    Sirion Biotech Customized adenovirus for overexpression of CHD1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CHD1 (see all 5)
    OriGene ORF clones in mouse, rat for CHD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHD1 (NM_001270)
    Sino Biological Human cDNA Clone for CHD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHD1
    Search LifeMap BioReagents cell lines for CHD1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CHD1
        Chromatin Regulation / Acetylation




    CHD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/53 Interacting proteins for CHD1 (O146461, 3 ENSP000002840494) via UniProtKB, MINT, STRING, and/or I2D (see all 53)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3AP684313, ENSP000003502754I2D: score=1 STRING: ENSP00000350275
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    HIST1H3DP684313I2D: score=1 
    HIST1H3EP684313I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006338chromatin remodeling IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9326634

    CHD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CHD1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHD1

    1 DrugBank Compound for CHD1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Epirubicin-- 56420-45-2targetantagonist17139284 17016423

    1 Novoseek inferred chemical compound relationship for CHD1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 39.9 3 17433364 (2)

    Search CenterWatch for drugs/clinical trials and news about CHD1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHD1 gene: 
    NM_001270.2  

    Unigene Cluster for CHD1:

    Chromodomain helicase DNA binding protein 1
    Hs.643465  [show with all ESTs]
    Unigene Representative Sequence: NM_001270
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514344(uc010jbn.3) ENST00000512392 ENST00000284049(uc003knf.3)
    ENST00000512844 ENST00000513064 ENST00000505657 ENST00000511067 ENST00000508756
    ENST00000414220 ENST00000511628 ENST00000505982
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHD1
    8/68 QIAGEN miScript miRNA Assays for microRNAs that regulate CHD1 (see all 68):
    hsa-miR-100* hsa-miR-4272 hsa-miR-30d hsa-miR-4275 hsa-miR-30a hsa-miR-489 hsa-miR-3613-3p hsa-miR-4293
    SwitchGear 3'UTR luciferase reporter plasmidCHD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CHD1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHD1
    Clone
    Products:
         
    OriGene clones in human, mouse for CHD1 (see all 5)
    OriGene ORF clones in mouse, rat for CHD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHD1 (NM_001270)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CHD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHD1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHD1

    Additional mRNA sequence: 

    AF006513.1 AK094871.1 BC054860.1 BC117134.1 BX648767.1 

    8 DOTS entries:

    DT.91913190  DT.100660877  DT.444956  DT.444955  DT.100774400  DT.120836582  DT.91861675  DT.100672370 

    24/137 AceView cDNA sequences (see all 137):

    AU125712 AK094871 BX495008 AI990247 C01297 BQ719338 CB215482 AW468529 
    BM681939 AI088996 BM723433 AA758842 BM692646 BE048526 BX501917 AW075773 
    AA599181 CB242516 BE612384 AA343708 BU186631 AL710223 H99736 BM763132 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CHD1 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30a · 30b ^ 31 ^ 32 ^ 33a · 33b ^ 34 ^ 35 ^ 36 ^ 37a · 37b ^ 38
    SP1:                                                                                                            
    SP2:                                            -           -                                                   
    SP3:                                                                                                            
    SP4:                                                                                                            
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for CHD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCTGGAAAC
    CHD1 Expression
    About this image


    See CHD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHD1

    SOURCE GeneReport for Unigene cluster: Hs.643465
        SABiosciences Expression via Pathway-Focused PCR Array including CHD1: 
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CHD1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHD1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHD1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHD1 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chd11 , 5 chromodomain helicase DNA binding protein 11, 5 88.13(n)1
    96.02(a)1
      17 (8.95 cM)5
    126481  NM_007690.31  NP_031716.21 
     157049675 
    chicken
    (Gallus gallus)
    Aves CHD11 chromodomain helicase DNA binding protein 1 77.5(n)
    83.64(a)
      395783  NM_204941.1  NP_990272.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHD16
    Uncharacterized protein
    86(a)
    1 ↔ 1
    2(27407616-27455512)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.174482 Transcribed sequence with moderate similarity to protein more 81.32(n)    AL960736.2 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1735061 zgc:173506 71.67(n)
    81.18(a)
      563236  NM_001128298.2  NP_001121770.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Chd13 chromatin binding 54(a)   2 23C4   --
    worm
    (Caenorhabditis elegans)
    Secernentea H06O01.23
    chd-11
    chromodomain-helicase-DNA-biniding
    protein3
    Protein CHD-11
    48(a)3
    54.7(n)1
    48.1(a)1
      I(7017609-7023274)3
    1724321  NM_059593.51  NP_491994.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CHD16
    Chromatin remodeler that regulates various aspects...
    34(a)
    1 → many
    V(505392-509798)
    soybean
    (Glycine max)
    eudicotyledons 467604242   -- 77.88(n)  


    ENSEMBL Gene Tree for CHD1 (if available)
    TreeFam Gene Tree for CHD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHD1 gene
    CHD62  CHD52  CHD82  CHD92  CHD32  CHD42  CHD72  CHD22  
    3 SIMAP similar genes for CHD1 using alignment to 5 protein entries:     CHD1_HUMAN (see all proteins):
    CHD2    C17orf64    SMARCA5

    CHD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1549 SNPs in CHD1 are shown (see all 1549)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1495262211,2
    --98190458(+) AATATC/TTGTAG 1 -- ds50010--------
    rs171663971,2
    C,F,H--98190612(+) GCTGAA/GTATAA 1 -- ds500111Minor allele frequency- G:0.05NA NS EA WA 1340
    rs1835530071,2
    --98190644(+) TAAATA/GTAAAG 1 -- ds50010--------
    rs1887422811,2
    --98190662(+) TAATAA/GTATCT 1 -- ds50010--------
    rs1141725271,2
    F--98190690(+) GCCAAC/GAAAAA 1 -- ds50011Minor allele frequency- G:0.01NA 120
    rs1440564471,2
    C--98190737(+) ATAGTA/CTCCAA 1 -- ds50010--------
    rs1404803731,2
    --98190739(+) AGTCTA/CCAAAA 1 -- ds50010--------
    rs1447562541,2
    --98190801(+) TACTTC/TTTCTG 1 -- ds50010--------
    rs1474808481,2
    --98190830(+) AAAACA/GGGGGT 1 -- ds50010--------
    rs357365451,2
    C--98190841(+) AGGGGG/CCGGTG 1 -- ds50011Minor allele frequency- C:0.50NA 2

    HapMap Linkage Disequilibrium report for CHD1 (98190908 - 98262240 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CHD1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv507277CNV Insertion20534489
    dgv6224n71CNV Loss21882294
    nsv882414CNV Gain21882294


    Human Gene Mutation Database (HGMD): CHD1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CHD1
    DNA2.0 Custom Variant and Variant Library Synthesis for CHD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602118    OMIM disorders: --

    11 diseases for CHD1:    About MalaCards
    cystic echinococcosis    periventricular nodular heterotopia    echinococcosis    sinusitis
    gastric cancer    hepatocellular carcinoma    pancreatic cancer    prostate cancer
    pancreatitis    prostatitis    breast cancer


    CHD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHD1
    Human Genome Epidemiology (HuGE) Navigator: CHD1 (5 documents)

    Export disorders for CHD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHD1 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with CHD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the CHD family of proteins. (PubMed id 9326634)1, 2, 3 Woodage T.... Collins F.S. (1997)
    2. Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. (PubMed id 16263726)1, 2, 9 Sims R.J. III...Reinberg D. (2005)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Interleukin 10 polymorphisms differentially influence the risk of gastric cancer in East Asians and Caucasians. (PubMed id 20363151)1, 4 Won H.H....Lee K.A. (2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Double chromodomains cooperate to recognize the methylated histone H3 tail. (PubMed id 16372014)1, 2 Flanagan J.F.... Khorasanizadeh S. (2005)
    7. A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain. (PubMed id 8460153)1, 3 Delmas V....Perry R.P. (1993)
    8. DNA-binding and chromatin localization properties of CHD1. (PubMed id 7739555)1, 9 Stokes D.G. and Perry R.P. (1995)
    9. CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. (PubMed id 10199952)1, 9 Kelley D.E....Perry R.P. (1999)
    10. Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (PubMed id 18042460)2, 9 Sims R.J. III... Reinberg D. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1105 HGNC: 1915 AceView: CHD1 Ensembl:ENSG00000153922 euGenes: HUgn1105
    ECgene: CHD1 H-InvDB: CHD1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHD1 gene:
    Search GeneIP for patents involving CHD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CHD1
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CHD1 (CHD1)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHD1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CHD1  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHD1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CHD1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHD1   OriGene Custom Protein Services for CHD1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHD1
     QIAGEN SeqTarget long-range PCR primers for resequencing CHD1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHD1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHD1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHD1
     GenScript Custom Purified and Recombinant Proteins Services for CHD1 GenScript cDNA clones with any tag delivered in your preferred vector for CHD1
     GenScript Custom Assay Services for CHD1 GenScript Custom Superior Antibodies Services for CHD1
     GenScript Custom overexpressing Cell Line Services for CHD1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for CHD1  (CHD-1)

     Regulatory tfbs in CHD1 promoter
     Search Chromatin IP Primers for CHD1
     RT2 qPCR Primer Assay in human, mouse, rat CHD1
     GNC Network for CHD1
     SABiosciences PCR Arrays including human, mouse, rat CHD1
     Search Tocris compounds for CHD1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CHD1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CHD1 antibodies
     CHD1 proteins
     Antibodies for CHD1
     See all of Abcam's Antibodies, Kits and Proteins for CHD1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CHD1
     Antibodies for CHD1
     ELISAs for CHD1
     CLIAs for CHD1
     Search LifeMap BioReagents cell lines for CHD1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1
     SwitchGear 3'UTR luciferase reporter plasmids for CHD1
     SwitchGear Promoter luciferase reporter plasmids for CHD1
     Search ThermoFisher Antibodies for CHD1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CHD1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CHD1
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of CHD1
     LSBio Antibodies in human, mouse, rat for CHD1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHD1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4