CHD1 Gene
protein-coding GIFtS: 60
GCID: GC05M098219
|
|
chromodomain helicase DNA binding protein 1
| |
Aliases
for CHD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromodomain Helicase DNA Binding Protein 11 2 | | CHD-12 3 | | ATP-Dependent Helicase CHD12 3 | | Chromodomain-Helicase-DNA-Binding Protein 12 | | EC 3.6.4.123 | | EC 3.6.18 |
Export aliases for CHD1 gene to outside databasesPrevious GC identifers: GC05M097537 GC05M098601 GC05M098222 GC05M098267 GC05M093378 |
Summaries
for CHD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CHD1:
The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains andSNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structurethus altering access of the transcriptional apparatus to its chromosomal DNA template. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CHD1_HUMAN, O14646Function: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of thetranscription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also requiredfor efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription terminationstep. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but alsorequired to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase(HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as theU2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physicalbridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonicstem cells
Gene Wiki entry for CHD1
|
Genomic Views
for CHD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHD1 gene promoter:
TBP PPAR-gamma1 AML1a POU3F1 HTF PPAR-gamma2 YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q15-q21 Ensembl cytogenetic band: 5q21.1 HGNC cytogenetic band: 5q15-q21CHD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M098219: view genomic region
(about GC identifiers)
Start:
|
98,190,908 bp from pter |
End:
|
98,262,240 bp from pter |
Size:
|
71,333 bases |
Orientation:
|
minus strand |
|
Proteins
for CHD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHD1_HUMAN, O14646 (See
protein sequence)Recommended Name: Chromodomain-helicase-DNA-binding protein 1 Size: 1710 amino acids; 196688 Da
Subunit: Component of the SAGA complex (By similarity). Interacts with BCLAF1, NCoR, SRP20 and SAFB (By similarity).Specifically interacts with methylated H3K4me2 and H3K4me3. Interacts with the FACT complex, the PAF complex and theU2 snRNP. Interacts directly with PAF1, SFA3A1, SFA3A2, SFA3A3, SNF2 and SSRP1
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Is released into the cytoplasm when cells enter mitosisand is reincorporated into chromatin during telophase-cytokinesis (By similarity)
6 PDB 3D structures from  and Proteopedia  for CHD1:2B2T (3D)
2B2U (3D)
2B2V (3D)
2B2W (3D)
2B2Y (3D)
4B4C (3D)
Secondary accessions: Q17RZ3Alternative splicing: 2 isoforms: O14646-1 O14646-2 Explore the universe of human proteins at neXtProt for CHD1: NX_O14646
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14646
4/14 DME Specific Peptides for CHD1 (O14646) (see all 14)
CHD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001261.2
ENSEMBL proteins: ENSP00000284049 ENSP00000422589 ENSP00000422225
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
CHD1 for ontologies About GeneDecksing
CHD1 Antibody Products:
Assay Products for CHD1: |
Protein
Domains /
Families
for CHD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHD1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry O14646ProtoNet protein and cluster: O14646 4 Blocks protein families: IPB000330 SNF2 related domain IPB000953 Chromo domain IPB001005 Myb DNA-binding domain IPB002464 ATP-dependent helicase
UniProtKB/Swiss-Prot: CHD1_HUMAN, O14646Domain: The 2 chromodomains are involved in the binding to the histone H3 methyllysine at position 4 (H3K4me3)Similarity: Belongs to the SNF2/RAD54 helicase familySimilarity: Contains 2 chromo domainsSimilarity: Contains 1 helicase ATP-binding domainSimilarity: Contains 1 helicase C-terminal domain |
Function
for CHD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CHD1_HUMAN, O14646Function: ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of thetranscription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also requiredfor efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription terminationstep. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but alsorequired to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase(HDAC) activity (By similarity). Required for the bridging of SNF2, the FACT complex, the PAF complex as well as theU2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physicalbridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonicstem cellsCatalytic activity: ATP + H(2)O = ADP + phosphate Genatlas biochemistry entry for CHD1:DNA binding protein with two chromatin organization (chromo) domains and a helicase ATPase domain,1,binding A.T tracts,released into cytoplasm during mitosis,component of the chromatin remodeling complex
Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHD1 (NM_001270) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
CHD1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for CHD1:
Animal Models:
1 MGI phenotypic allele  for Chd1 (no phenotypes)
CHD1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CHD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Chromatin Regulation / Acetylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Cell Signaling Technology (CST) Pathway for CHD1
CHD1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CHD1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/47 Interacting proteins for CHD1 (O146461, 3 ENSP000002840494) via UniProtKB, MINT, STRING, and/or I2D (see all 47)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006338 | chromatin remodeling |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006357 | regulation of transcription from RNA polymerase II promoter |
TAS | 9326634 |
CHD1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CHD1 for compounds About GeneDecksing
 Browse Tocris compounds for CHD1
1 DrugBank Compound for CHD1 About this table
1 Novoseek chemical compound relationship for CHD1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lysine |
39.9 |
3 |
17433364 (2) |
Search CenterWatch for drugs/clinical trials and news about CHD1
|
Transcripts
for CHD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHD1 gene: NM_001270.2 Unigene Cluster for CHD1: Chromodomain helicase DNA binding protein 1 Hs.643465 [show with all ESTs]Unigene Representative Sequence: NM_00127011 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514344(uc010jbn.3) ENST00000512392 ENST00000284049(uc003knf.3)
ENST00000512844 ENST00000513064 ENST00000505657 ENST00000511067 ENST00000508756
ENST00000414220 ENST00000511628 ENST00000505982
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHD1 (NM_001270) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1 |
Additional cDNA sequence: AF006513.1 AK094871.1 BC054860.1 BC117134.1 BX648767.1 8 DOTS entries: DT.91913190 DT.100660877 DT.444956 DT.444955 DT.100774400 DT.120836582 DT.91861675 DT.100672370 24/137 AceView cDNA sequences (see all 137): H99736 AU125712 BU186631 BE612384 AI990247 BE048526 AW075773 AK094871 AL710223 BU173077 AA343708 BG036597 BM763132 BM728993 AA599181 BX495008 AA609977 BM692646 BQ436172 BX501917 CB242516 C01297 H80752 BM698633
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for CHD1 (see all 14) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b | ^ | 31 | ^ | 32 | ^ | 33a | · | 33b | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37a | · | 37b | ^ | 38 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CHD1
|
Expression
for CHD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTGGAAAC
About this image
See CHD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHD1
SOURCE GeneReport for Unigene cluster: Hs.643465
SABiosciences Expression via Pathway-Focused PCR Array including CHD1: | Epigenetic Chromatin Remodeling Factors in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHD1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1 |
Orthologs
for CHD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CHD1 gene from 9/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Chd11 , 5 |
chromodomain helicase DNA binding protein 11, 5 |
88.13(n)1
96.02(a)1 |
|
17 (8.95 cM)5
126481 NM_007690.31 NP_031716.21
157049675 |
chicken
(Gallus gallus) |
Aves |
CHD11 |
chromodomain helicase DNA binding protein 1 |
77.5(n)
83.64(a) |
|
395783 NM_204941.1 NP_990272.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CHD16 |
-- |
86(a) |
1 ↔ 1 |
2(27407616-27445544) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.174482 |
Transcribed sequence with moderate similarity to protein more |
81.32(n) |
|
AL960736.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:1735061 |
zgc:173506 |
71.67(n)
81.18(a) |
|
563236 NM_001128298.2 NP_001121770.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Chd13 |
chromatin binding |
54(a) |
|
2 23C4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
H06O01.23
chd-11 |
chromodomain-helicase-DNA-biniding protein3
Protein CHD-11 |
48(a)3
54.7(n)1
48.1(a)1 |
|
I(7017609-7023274)3
1724321 NM_059593.51 NP_491994.21 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
CHR56 |
chromatin remodeling 5 |
28(a) |
1 → many |
2(5544181-5556464) |
rice
(Oryza sativa) |
Liliopsida |
-- |
SNF2 family N-terminal domain containing protein, ... |
33(a) |
1 → many |
7(27824786-27833222) |
ENSEMBL Gene Tree for CHD1 (if available)
TreeFam Gene Tree for CHD1 (if available) |
Paralogs
for CHD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHD1 gene
- CHD62 CHD52 CHD82 CHD92 CHD32 CHD42 CHD72 CHD22
5 SIMAP similar genes for CHD1 using alignment to 5 protein entries: CHD1_HUMAN (see all proteins):CHD2 C17orf64 SMARCA5 HELLS SMARCA1
CHD1 for paralogs About GeneDecksing
|
Genomic Variants
for CHD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHD1 (98190908 - 98262240 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHD1: --
Human Gene Mutation Database (HGMD): CHD1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHD1 |
|
Disorders
/ Diseases
for CHD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CHD1 for disorders About GeneDecksing
OMIM gene information: 602118
OMIM disorders: --
8  diseases for CHD1: About MalaCardsperiventricular nodular heterotopia cystic echinococcosis heterotopia echinococcosis
hepatocellular carcinoma gastric cancer carcinoma malaria
Human Genome Epidemiology (HuGE) Navigator: CHD1 (5 documents)
Export disorders for CHD1 gene to outside databases
|
Publications
for CHD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHD1 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with CHD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the CHD family of proteins. (PubMed id 9326634)1, 2, 3 Woodage T.... Collins F.S. (1997)
- Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. (PubMed id 16263726)1, 2, 9 Sims R.J. III...Reinberg D. (2005)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Double chromodomains cooperate to recognize the methylated histone H3 tail. (PubMed id 16372014)1, 2 Flanagan J.F.... Khorasanizadeh S. (2005)
- A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain. (PubMed id 8460153)1, 3 Delmas V....Perry R.P. (1993)
- DNA-binding and chromatin localization properties of CHD1. (PubMed id 7739555)1, 9 Stokes D.G. and Perry R.P. (1995)
- CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. (PubMed id 10199952)1, 9 Kelley D.E....Perry R.P. (1999)
- Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. (PubMed id 18042460)2, 9 Sims R.J. III... Reinberg D. (2007)
- Molecular implications of evolutionary differences in CHD double chromodomains. (PubMed id 17433364)2, 9 Flanagan J.F....Khorasanizadeh S. (2007)
- Structural polymorphism of chromodomains in Chd1. (PubMed id 17098252)1, 9 Okuda M....Nishimura Y. (2007)
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External Searches for CHD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing CHD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing CHD1 gene
(According to HUGE)
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Specialized Databases showing CHD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for CHD1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for CHD1 gene:
Search GeneIP for patents involving CHD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for CHD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHD1 | | OriGene 3'-UTR Clone for CHD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHD1 | | OriGene Custom Protein Services for CHD1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHD1 |
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| | Antibodies & Assays for CHD1 (CHD-1) |
| | | | Search Tocris compounds for CHD1 |
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 | | | CHD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CHD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHD1 |
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