Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CHCHD6 Gene

protein-coding GIFtS: 45
GCID: GC03P126423

coiled-coil-helix-coiled-coil-helix domain containing 6

Search for CHCHD6
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6¹ ²		Coiled Coil Helix Cristae Morphology 1²
CHCM1¹ ² ³		Coiled-Coil-Helix Cristae Morphology 1²
PPP1R23¹ ²		Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6, Mitochondrial²
Coiled Coil Helix Cristae Morphology Protein 1² ³		Protein Phosphatase 1, Regulatory Subunit 23²
MGC13016¹

External Ids:	HGNC: 28184¹	Entrez Gene: 84303²	Ensembl: ENSG00000159685⁷	UniProtKB: Q9BRQ6³

Export aliases for CHCHD6 gene to outside databases

Previous GC identifers: GC03P127744 GC03P127905 GC03P123803

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CHCH6_HUMAN, Q9BRQ6

Function: Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CHCHD6 gene promoter:
Oct-B1 Nkx3-1 Nkx3-1 v4 oct-B3 oct-B2 Nkx3-1 v1 Nkx3-1 v2 POU2F1 POU2F1a Nkx3-1 v3
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CHCHD6 promoter sequence

Search SABiosciences Chromatin IP Primers for CHCHD6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHCHD6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.3 Ensembl cytogenetic band: 3q21.3 HGNC cytogenetic band: 3q21.3

CHCHD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHCHD6 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P126423: view genomic region (about GC identifiers)

Start:	126,423,063 bp from pter	End:	126,679,249 bp from pter
Size:	256,187 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CHCH6_HUMAN, Q9BRQ6 (See protein sequence)

Recommended Name: Coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial

Size: 235 amino acids; 26458 Da

Subunit: Interacts with CHCHD3 and DISC1. Interacts with IMMT; the interaction is direct

Subcellular location: Mitochondrion inner membrane; Lipid-anchor (Probable)

Secondary accessions: D6R9U0 D6RIB4 H8Y0Y7

Explore the universe of human proteins at neXtProt for CHCHD6: NX_Q9BRQ6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BRQ6

CHCHD6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115719.1

ENSEMBL proteins:

ENSP00000290913 ENSP00000427517 ENSP00000422912 ENSP00000422787

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CHCHD6 OriGene Protein Over-expression Lysate: CHCHD6 OriGene Custom Protein Services for CHCHD6
	GenScript Custom Purified and Recombinant Proteins Services for CHCHD6
	Novus Biologicals CHCHD6 Protein Novus Biologicals CHCHD6 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CHCHD6

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IMP	--
GO:0005743	mitochondrial inner membrane	IDA	--

CHCHD6 for ontologies About GeneDecksing

CHCHD6 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for CHCHD6
	GenScript Custom Superior Antibodies Services for CHCHD6
	Novus Biologicals CHCHD6 Antibodies
	Search for Antibodies for CHCHD6 at Abcam
	Uscn Antibodies for CHCHD6
	Search ThermoFisher Antibodies for CHCHD6

Assay Products for CHCHD6:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CHCHD6
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CHCHD6

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CHCHD6 for domains About GeneDecksing

1 InterPro domain/family:

IPR007964 DUF737

Graphical View of Domain Structure for InterPro Entry Q9BRQ6

ProtoNet protein and cluster: Q9BRQ6

1 Blocks protein family: IPB010625 CHCH

UniProtKB/Swiss-Prot: CHCH6_HUMAN, Q9BRQ6

Similarity: Belongs to the CHCHD6 family

Similarity: Contains 1 CHCH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CHCH6_HUMAN, Q9BRQ6

Function: Required for maintaining mitochondrial crista morphology, ATP production and oxygen consumption

Induction: Down-regulated following genotoxic stress

miRNA Products:		OriGene 3'-UTR Clone: CHCHD6 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHCHD6
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CHCHD6:
		hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: CHCHD6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHCHD6 (see all 7) OriGene shRNA RFP: CHCHD6 OriGene siRNA: CHCHD6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHCHD6

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CHCHD6

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHCHD6 (NM_032343)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHCHD6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD6

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CHCHD6
		Search LifeMap BioReagents cell lines for CHCHD6

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CHCHD6

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--

CHCHD6 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CHCHD6

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/8 Interacting proteins for CHCHD6 (Q9BRQ6^{2, 3} ENSP00000290913⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
IMMT	Q16891², ENSP00000387262⁴	MINT-5007196 STRING: ENSP00000387262
CHCHD3	Q9NX63²	MINT-5007196
DNAJC11	Q9NVH1²	MINT-5007196
MTX1	Q13505²	MINT-5007196

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006974	response to DNA damage stimulus	IDA	--
GO:0042407	cristae formation	IMP	--

CHCHD6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHCHD6
Search CenterWatch for drugs/clinical trials and news about CHCHD6 / CHCH6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHCHD6 gene:

NM_032343.2

Unigene Cluster for CHCHD6:

Coiled-coil-helix-coiled-coil-helix domain containing 6

Hs.518119 [show with all ESTs]

Unigene Representative Sequence: BU146817

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000290913(uc003ejf.1) ENST00000503119 ENST00000508789(uc010hsj.1)

ENST00000514908 ENST00000513253 ENST00000515867 ENST00000504973 ENST00000510044

miRNA Products:		OriGene 3'-UTR Clone: CHCHD6 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CHCHD6
		1 QIAGEN miScript miRNA Assays for microRNA that regulate CHCHD6:
		hsa-miR-570
		SwitchGear 3'UTR luciferase reporter plasmid: CHCHD6 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHCHD6 (see all 7) OriGene shRNA RFP: CHCHD6 OriGene siRNA: CHCHD6
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHCHD6

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD6 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD6 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CHCHD6 (NM_032343)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHCHD6
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHCHD6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CHCHD6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHCHD6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHCHD6

Additional cDNA sequence:

AK310910.1 AK311056.1 BC006123.1 JF264889.1

10 DOTS entries:

DT.440950 DT.113352 DT.97859860 DT.120885873 DT.100730127 DT.120885891 DT.95277804 DT.91752016

DT.95344432 DT.97771851

24/178 AceView cDNA sequences (see all 178):

CD676241 BM713328 BM758187 AL522151 AI092411 BE265275 BQ185922 CF126500

AA688216 BM684502 NM_032343 AW628914 BM727213 BU740774 BC006123 AI890974

AI241133 BM674675 CD672888 BG205002 BM681429 BM931016 BM462603 BQ214808

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHCHD6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGACCACAGC

About this image

CHCHD6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Endocardial Tube Cells

Endocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CHCHD6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHCHD6

SOURCE GeneReport for Unigene cluster: Hs.518119

SABiosciences Custom PCR Arrays for CHCHD6

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHCHD6 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CHCHD6
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHCHD6
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHCHD6

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CHCHD6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CHCHD6 gene from 5/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Chchd6^{1 , 5}	coiled-coil-helix-coiled-coil-helix domain containing more^{1, 5}	78.01(n)¹ 68.51(a)¹		6 (39.91 cM)⁵ 66098¹ NM_025351.3¹ NP_079627.3¹ 89383146⁵
chicken (Gallus gallus)	Aves	CHCHD6¹	coiled-coil-helix-coiled-coil-helix domain containing more	60.26(n) 51.28(a)		416029 XM_414369.3 XP_414369.2
lizard (Anolis carolinensis)	Reptilia	CHCHD6⁶	--	42(a)	1 ↔ 1	2(166283538-166293377)
zebrafish (Danio rerio)	Actinopterygii	chchd6a¹	coiled-coil-helix-coiled-coil-helix domain containing more	53.45(n) 42.24(a)		449542 NM_001005584.1 NP_001005584.1
fruit fly (Drosophila melanogaster)	Insecta	l(3)03670⁶	lethal (3) 03670	18(a)	1 → many	3R(26878338-26879637)

ENSEMBL Gene Tree for CHCHD6 (if available)
TreeFam Gene Tree for CHCHD6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CHCHD6 gene

CHCHD3²

1 SIMAP similar gene for CHCHD6 using alignment to 4 protein entries: CHCH6_HUMAN (see all proteins):

CHCHD3

CHCHD6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75061206^1,2	C,	--	123804464(+)	`ACCCAG/ATAAAA`	1	--	us2k¹		2		CSA WA	120
rs11928317^1,2	H	--	123805302(+)	`CTGTCC/TTGACA`	1	--	us2k¹		0	--	--	--	--
rs116612771^1,2	C,F,	--	123805569(+)	`TGAGGG/ATTGAG`	1	--	us2k¹		1		NA	120
rs11713103^1,2	H	--	123806155(+)	`TTCAAA/CCCGTA`	1	--	us2k¹		0	--	--	--	--
rs73859586^1,2	C,	--	123806158(+)	`AAACCG/ATAATT`	1	--	us2k¹		2		WA	120
rs9289283^1,2	C,F,A,H,	--	123806406(+)	`AGCATC/TCAGAC`	1	--	nc-transcript-variant		15		NS EA NA WA CSA	1488
rs73199883^1,2	C,F,	--	123806499(+)	`TATCCC/TCTCCA`	1	--	nc-transcript-variant		1		NA	120
rs114083200^1,2	C,F,	--	123806529(+)	`TCATGC/TATTGC`	1	--	nc-transcript-variant		1		NA	120
rs1177579^1,2	A,H	--	123807252(-)	`CTCCAG/AAATAA`	1	--	nc-transcript-variant		8		NS EA NA	672
rs9809215^1,2	C,F,A,H,	--	126421345(+)	`AAAAGG/ATAATT`	1	--	us2k¹ tfbs³ trp³		19		NS EA NA WA CSA	2340

HapMap Linkage Disequilibrium report for CHCHD6 (126423063 - 126673063 bp, first 250kb of CHCHD6)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for CHCHD6
3 CNVs: 23662 68452 98439
3 Indels: 12332 41563 11208

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHCHD6

DNA2.0 Custom Variant and Variant Library Synthesis for CHCHD6

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CHCHD6 for disorders About MalaCards

CHCHD6 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: CHCHD6 (2 documents)

Export disorders for CHCHD6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CHCHD6 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CHCHD6)

Utopia: connect your pdf to the dynamic
world of online information

CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. (PubMed id 22228767)^{1, 2, 3} An J.... Sheikh M.S. (2012)
The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil-helix domain-containing protein 3 and 6 and DnaJC11. (PubMed id 17624330)^{1, 2, 3} Xie J....Capaldi R.A. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)
Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)¹ Trynka G....Wijmenga C. (2009)
Docking motif-guided mapping of the interactome of protein phosphatase-1. (PubMed id 19389623)¹ Hendrickx A.... Bollen M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84303	HGNC: 28184	AceView: CHCHD6	Ensembl:ENSG00000159685	euGenes: HUgn84303
ECgene: CHCHD6	H-InvDB: CHCHD6

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CHCHD6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CHCHD6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CHCHD6 gene:
Search GeneIP for patents involving CHCHD6

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for CHCHD6
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHCHD6		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHCHD6
	OriGene Protein Over-expression Lysate for CHCHD6		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CHCHD6		OriGene 3'-UTR Clone for CHCHD6
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD6		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD6
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CHCHD6		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CHCHD6		OriGene Custom Protein Services for CHCHD6
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHCHD6
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHCHD6
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHCHD6
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHCHD6
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHCHD6
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHCHD6

	GenScript Custom Purified and Recombinant Proteins Services for CHCHD6		GenScript cDNA clones with any tag delivered in your preferred vector for CHCHD6
	GenScript Custom Assay Services for CHCHD6		GenScript Custom Superior Antibodies Services for CHCHD6
	GenScript Custom overexpressing Cell Line Services for CHCHD6		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CHCHD6 promoter
	Search Chromatin IP Primers for CHCHD6
	RT² qPCR Primer Assay in human, mouse, rat CHCHD6
	Search GNC Networks for CHCHD6
	SABiosciences Custom PCR Arrays for CHCHD6

Search Tocris compounds for CHCHD6

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CHCHD6 antibodies
	CHCHD6 proteins
	CHCHD6 lysates

	Search for Antibodies for CHCHD6 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CHCHD6
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

CHCHD6 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CHCHD6

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CHCHD6

	SwitchGear 3'UTR luciferase reporter plasmids for CHCHD6
	SwitchGear Promoter luciferase reporter plasmids for CHCHD6

Search ThermoFisher Antibodies for CHCHD6

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD6

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CHCHD6 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CHCHD6 Gene

coiled-coil-helix-coiled-coil-helix domain containing 6

Aliases
for CHCHD6 gene

Summaries
for CHCHD6 gene

Genomic Views
for CHCHD6 gene

Proteins
for CHCHD6 gene

Protein Domains /
Families
for CHCHD6 gene

Function
for CHCHD6 gene

Pathways & Interactions
for CHCHD6 gene

Drugs & Compounds
for CHCHD6 gene

Transcripts
for CHCHD6 gene

Expression
for CHCHD6 gene

Orthologs
for CHCHD6 gene

Paralogs
for CHCHD6 gene

Genomic Variants
for CHCHD6 gene

Disorders / Diseases
for CHCHD6 gene

Publications
for CHCHD6 gene

External Searches for CHCHD6 gene

Genome Databases showing CHCHD6 gene

Other Databases showing CHCHD6 gene

Specialized Databases showing CHCHD6 gene

Intellectual Property
for CHCHD6 gene

Products
for CHCHD6 gene

View Random Gene

Advanced Search

Export list of displayed genes

CHCHD6 Gene

coiled-coil-helix-coiled-coil-helix domain containing 6

Aliasesfor CHCHD6 gene

Summariesfor CHCHD6 gene

Genomic Viewsfor CHCHD6 gene

Proteinsfor CHCHD6 gene

Protein Domains /Familiesfor CHCHD6 gene

Functionfor CHCHD6 gene

Pathways & Interactionsfor CHCHD6 gene

Drugs & Compoundsfor CHCHD6 gene

Transcriptsfor CHCHD6 gene

Expression for CHCHD6 gene

Orthologsfor CHCHD6 gene

Paralogsfor CHCHD6 gene

Genomic Variantsfor CHCHD6 gene

Disorders / Diseasesfor CHCHD6 gene

Publicationsfor CHCHD6 gene

External Searches for CHCHD6 gene

Genome Databases showing CHCHD6 gene

Other Databases showing CHCHD6 gene

Specialized Databases showing CHCHD6 gene

Intellectual Propertyfor CHCHD6 gene

Productsfor CHCHD6 gene

View Random Gene

Aliases
for CHCHD6 gene

Summaries
for CHCHD6 gene

Genomic Views
for CHCHD6 gene

Proteins
for CHCHD6 gene

Protein Domains /
Families
for CHCHD6 gene

Function
for CHCHD6 gene

Pathways & Interactions
for CHCHD6 gene

Drugs & Compounds
for CHCHD6 gene

Transcripts
for CHCHD6 gene

Expression
for CHCHD6 gene

Orthologs
for CHCHD6 gene

Paralogs
for CHCHD6 gene

Genomic Variants
for CHCHD6 gene

Disorders / Diseases
for CHCHD6 gene

Publications
for CHCHD6 gene

Intellectual Property
for CHCHD6 gene

Products
for CHCHD6 gene