Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHCHD6 Gene

Aliases for CHCHD6 Gene

  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6 2 3
  • CHCM1 3 4 6
  • Coiled-Coil-Helix Cristae Morphology Protein 1 3 4
  • Coiled-Coil-Helix Cristae Morphology 1 2 3
  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6, Mitochondrial 3
  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 6 4
  • Coiled Coil Helix Cristae Morphology Protein 1 3
  • Protein Phosphatase 1, Regulatory Subunit 23 3
  • Coiled Coil Helix Cristae Morphology 1 3
  • MICOS Complex Subunit MIC25 3
  • Protein Phosphatase 1 2
  • Regulatory Subunit 23 2
  • PPP1R23 3
  • MIC25 4

External Ids for CHCHD6 Gene

Previous GeneCards Identifiers for CHCHD6 Gene

  • GC03P127744
  • GC03P127905
  • GC03P126423
  • GC03P123803

Summaries for CHCHD6 Gene

GeneCards Summary for CHCHD6 Gene

CHCHD6 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 6) is a Protein Coding gene. An important paralog of this gene is CHCHD3.

UniProtKB/Swiss-Prot for CHCHD6 Gene

  • Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHCHD6 Gene

Genomics for CHCHD6 Gene

Regulatory Elements for CHCHD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHCHD6 Gene

Start:
126,704,220 bp from pter
End:
126,960,420 bp from pter
Size:
256,201 bases
Orientation:
Plus strand

Genomic View for CHCHD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHCHD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHCHD6 Gene

Proteins for CHCHD6 Gene

  • Protein details for CHCHD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRQ6-MIC25_HUMAN
    Recommended name:
    MICOS complex subunit MIC25
    Protein Accession:
    Q9BRQ6
    Secondary Accessions:
    • D6R9U0
    • D6RIB4
    • H8Y0Y7

    Protein attributes for CHCHD6 Gene

    Size:
    235 amino acids
    Molecular mass:
    26458 Da
    Quaternary structure:
    • Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MINOS1/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27 and IMMT/MIC60. The complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2, and with HSPA9. Interacts with DISC1.

neXtProt entry for CHCHD6 Gene

Proteomics data for CHCHD6 Gene at MOPED

Post-translational modifications for CHCHD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHCHD6 Gene

No data available for DME Specific Peptides for CHCHD6 Gene

Domains for CHCHD6 Gene

Gene Families for CHCHD6 Gene

HGNC:
  • CHCHD :Coiled-coil-helix-coiled-coil-helix domain containing
  • PPP1R :Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

Protein Domains for CHCHD6 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHCHD6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRQ6

UniProtKB/Swiss-Prot:

MIC25_HUMAN :
  • Q9BRQ6
Domain:
  • Contains 1 CHCH domain.
Family:
  • Belongs to the MICOS complex subunit Mic19 family. Metazoan Mic25 subfamily.
genes like me logo Genes that share domains with CHCHD6: view

Function for CHCHD6 Gene

Molecular function for CHCHD6 Gene

UniProtKB/Swiss-Prot Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
UniProtKB/Swiss-Prot Induction: Down-regulated following genotoxic stress.

Gene Ontology (GO) - Molecular Function for CHCHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22228767
genes like me logo Genes that share ontologies with CHCHD6: view

Animal Model Products

CRISPR Products

miRNA for CHCHD6 Gene

miRTarBase miRNAs that target CHCHD6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHCHD6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHCHD6 Gene

Localization for CHCHD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHCHD6 Gene

Mitochondrion inner membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHCHD6 Gene COMPARTMENTS Subcellular localization image for CHCHD6 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CHCHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IMP 22228767
GO:0005743 mitochondrial inner membrane IDA 22228767
genes like me logo Genes that share ontologies with CHCHD6: view

Pathways for CHCHD6 Gene

SuperPathways for CHCHD6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHCHD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 22228767
GO:0042407 cristae formation IMP 22228767
genes like me logo Genes that share ontologies with CHCHD6: view

No data available for Pathways by source for CHCHD6 Gene

Transcripts for CHCHD6 Gene

Unigene Clusters for CHCHD6 Gene

Coiled-coil-helix-coiled-coil-helix domain containing 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHCHD6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHCHD6 Gene

No ASD Table

Relevant External Links for CHCHD6 Gene

GeneLoc Exon Structure for
CHCHD6
ECgene alternative splicing isoforms for
CHCHD6

Expression for CHCHD6 Gene

mRNA expression in normal human tissues for CHCHD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHCHD6 Gene

SOURCE GeneReport for Unigene cluster for CHCHD6 Gene Hs.518119

genes like me logo Genes that share expressions with CHCHD6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHCHD6 Gene

Orthologs for CHCHD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHCHD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHCHD6 35
  • 99.15 (n)
  • 98.72 (a)
CHCHD6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHCHD6 35
  • 74.17 (n)
  • 61.47 (a)
CHCHD6 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHCHD6 35
  • 82.54 (n)
  • 76.62 (a)
CHCHD6 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chchd6 35
  • 77.87 (n)
  • 67.66 (a)
Chchd6 16
Chchd6 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHCHD6 36
  • 38 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chchd6 35
  • 77.25 (n)
  • 66.09 (a)
chicken
(Gallus gallus)
Aves CHCHD6 35
  • 63.36 (n)
  • 57.21 (a)
lizard
(Anolis carolinensis)
Reptilia CHCHD6 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chchd6 35
  • 56.13 (n)
  • 49.57 (a)
zebrafish
(Danio rerio)
Actinopterygii chchd6a 35
  • 53.22 (n)
  • 42.06 (a)
chchd6a 36
  • 38 (a)
OneToMany
chchd6b 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5473 36
  • 25 (a)
OneToMany
Species with no ortholog for CHCHD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHCHD6 Gene

ENSEMBL:
Gene Tree for CHCHD6 (if available)
TreeFam:
Gene Tree for CHCHD6 (if available)

Paralogs for CHCHD6 Gene

Paralogs for CHCHD6 Gene

Selected SIMAP similar genes for CHCHD6 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CHCHD6: view

Variants for CHCHD6 Gene

Sequence variations from dbSNP and Humsavar for CHCHD6 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs724885 -- 126,842,471(+) GCTCA(A/G)GATGG intron-variant
rs730257 -- 126,917,513(+) CCTCC(A/G)TTTCC intron-variant
rs732462 -- 126,926,131(-) TTAGA(C/G)AGCCT intron-variant
rs734506 -- 126,925,703(+) TGGAC(A/G)CTGCT intron-variant
rs745941 -- 126,925,581(+) TGAGC(A/C)GCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHCHD6 Gene

Variant ID Type Subtype PubMed ID
nsv829718 CNV Gain 17160897
esv33263 CNV Gain 17666407
esv2666675 CNV Deletion 23128226
esv268512 CNV Insertion 20981092
esv2660854 CNV Deletion 23128226
esv2552936 CNV Loss 19546169
esv22081 CNV Loss 19812545
nsv821409 CNV Deletion 20802225
nsv511217 CNV Loss 21212237
esv1444905 CNV Deletion 17803354
esv2725875 CNV Deletion 23290073
esv2725876 CNV Deletion 23290073
nsv829719 CNV Gain 17160897
nsv877445 CNV Loss 21882294
nsv3986 CNV Insertion 18451855
esv2725877 CNV Deletion 23290073
esv1002711 CNV Deletion 20482838
nsv526947 CNV Loss 19592680
esv2725878 CNV Deletion 23290073
esv2725879 CNV Deletion 23290073
esv3701 CNV Deletion 18987735
esv2725880 CNV Deletion 23290073
esv2666215 CNV Deletion 23128226
nsv237087 CNV Loss 16902084
esv2725881 CNV Deletion 23290073
nsv460846 CNV Loss 19166990

Relevant External Links for CHCHD6 Gene

HapMap Linkage Disequilibrium report
CHCHD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHCHD6 Gene

Disorders for CHCHD6 Gene

Relevant External Links for CHCHD6

Genetic Association Database (GAD)
CHCHD6
Human Genome Epidemiology (HuGE) Navigator
CHCHD6
genes like me logo Genes that share disorders with CHCHD6: view

No data available for UniProtKB/Swiss-Prot for CHCHD6 Gene

Publications for CHCHD6 Gene

  1. The mitochondrial inner membrane protein mitofilin exists as a complex with SAM50, metaxins 1 and 2, coiled-coil-helix coiled-coil- helix domain-containing protein 3 and 6 and DnaJC11. (PMID: 17624330) Xie J. … Capaldi R.A. (FEBS Lett. 2007) 2 3 4
  2. CHCM1/CHCHD6, a novel mitochondrial protein linked to regulation of mitofilin and mitochondrial cristae morphology. (PMID: 22228767) An J. … Sheikh M.S. (J. Biol. Chem. 2012) 2 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for CHCHD6 Gene

Sources for CHCHD6 Gene

Back to Top

Content