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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHCHD5 Gene

protein-coding   GIFtS: 43
GCID: GC02P113341

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 5

(Previous name: chromosome 2 open reading frame 9)
(Previous symbol: C2orf9)
  Search for CHCHD5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 51 2     MIC142
C2orf91 2 3     Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 52
Chromosome 2 Open Reading Frame 91     Mitochondrial Intermembrane Space Cysteine Motif Protein Of 14 KDa Homolog2
Mitochondrial Intermembrane Space Cysteine Motif Protein Of 14 KDa Homolog
(S. Cerevisiae)1
     

External Ids:    HGNC: 178401   Entrez Gene: 842692   Ensembl: ENSG000001256117   UniProtKB: Q9BSY43   

Export aliases for CHCHD5 gene to outside databases

Previous GC identifers: GC02P113437 GC02P113058 GC02P105796


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CHCHD5 Gene: 
CHCHD5 (coiled-coil-helix-coiled-coil-helix domain containing 5) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022135.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHCHD5 gene promoter:
         AP-4   c-Ets-1   NF-YB   CBF-A   CBF-B   FOXO1a   CP1A   NF-Y   CBF(2)   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHCHD5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHCHD5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHCHD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q13   Ensembl cytogenetic band:  2q13   HGNC cytogenetic band: 2q14.1

CHCHD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHCHD5 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P113341:  view genomic region     (about GC identifiers)

Start:
113,341,817 bp from pter      End:
113,346,852 bp from pter
Size:
5,036 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CHCH5_HUMAN, Q9BSY4 (See protein sequence)
Recommended Name: Coiled-coil-helix-coiled-coil-helix domain-containing protein 5  
Size: 110 amino acids; 12395 Da
Subunit: Monomer
Subcellular location: Mitochondrion intermembrane space (Potential)
1 PDB 3D structure from and Proteopedia for CHCHD5:
2LQL (3D)    
Secondary accessions: Q585T4

Explore the universe of human proteins at neXtProt for CHCHD5: NX_Q9BSY4

Explore proteomics data for CHCHD5 at MOPED 

CHCHD5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CHCHD5 Protein Expression

REFSEQ proteins: NP_115685.1  
ENSEMBL proteins: 
 ENSP00000325655   ENSP00000412731   ENSP00000386994  

Human Recombinant Protein Products for CHCHD5: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005758mitochondrial intermembrane space IEA--

CHCHD5 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
CHCHD: Coiled-coil-helix-coiled-coil-helix domain containing

1 InterPro protein domain:
 IPR010625 CHCH

Graphical View of Domain Structure for InterPro Entry Q9BSY4

ProtoNet protein and cluster: Q9BSY4

1 Blocks protein domain: IPB010625 CHCH

UniProtKB/Swiss-Prot: CHCH5_HUMAN, Q9BSY4
Similarity: Contains 1 CHCH domain


CHCHD5 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     6 GenomeRNAi human phenotypes for CHCHD5:
 Decreased viability with pacli  G2 arrest  Increased G2M DNA content, inc  Increased HPV18 LCR reporter a 
 Increased gamma-H2AX phosphory  Increased number of cells in m 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section




Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHCHD5

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CHCHD5 (CHCH5)

Search CenterWatch for drugs/clinical trials and news about CHCHD5 / CHCH5

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CHCHD5 gene: 
NM_032309.2  

Unigene Cluster for CHCHD5:

Coiled-coil-helix-coiled-coil-helix domain containing 5
Hs.375707  [show with all ESTs]
Unigene Representative Sequence: AK024631
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000489052 ENST00000324913(uc002thz.1) ENST00000454841 ENST00000409719(uc002tia.2)
ENST00000469030
miRNA
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHCHD5

Additional mRNA sequence: 

AK024631.1 AK312219.1 BC004498.2 

11 DOTS entries:

DT.453478  DT.87015011  DT.95372616  DT.100780138  DT.100780140  DT.91715213  DT.97770700  DT.95372613 
DT.434366  DT.91732061  DT.97845860 

24/132 AceView cDNA sequences (see all 132):

BM694303 AW468823 F03119 BX380845 BI522654 CR625580 BX400108 CR621804 
BU688796 AI435438 BF112002 AI885087 BM563093 BM993430 AI885186 BQ771639 
BI917104 AI039804 AA845436 BE728850 BC004498 BM702285 CA335815 F28807 

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CHCHD5 (see all 6)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1:                    -     -           -           -               
SP2:                          -           -           -               
SP3:                                      -           -               
SP4:                          -                       -               
SP5:                          -           -                           


ECgene alternative splicing isoforms for CHCHD5

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CHCHD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGCCCGGCTT
CHCHD5 Expression
About this image


See CHCHD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHCHD5

SOURCE GeneReport for Unigene cluster: Hs.375707
    SABiosciences Custom PCR Arrays for CHCHD5
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHCHD5
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHCHD5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CHCHD5 gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Chchd51 , 5 coiled-coil-helix-coiled-coil-helix domain containing more1, 5 85.76(n)1
90(a)1
  2 (62.72 cM)5
661701  NM_025395.31  NP_079671.11 
 1291297005 
chicken
(Gallus gallus)
Aves CHCHD51 coiled-coil-helix-coiled-coil-helix domain containing more 69.1(n)
60.42(a)
  770886  XM_001232275.2  XP_001232276.1 
lizard
(Anolis carolinensis)
Reptilia CHCHD56
Uncharacterized protein
62(a)
1 ↔ 1
GL343198.1(4343420-4344829)
zebrafish
(Danio rerio)
Actinopterygii LOC1000006461 coiled-coil-helix-coiled-coil-helix domain-containing more 58.78(n)
48.39(a)
  100000646  XM_001334662.3  XP_001334698.1 


ENSEMBL Gene Tree for CHCHD5 (if available)
TreeFam Gene Tree for CHCHD5 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/157 SNPs in CHCHD5 are shown (see all 157)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1466573651,2
C--113340085(+) CGTAG-/AATTTT 1 -- us2k10--------
rs58334501,2
C--113340086(+) TTTTT-/T/TT  
        
GAGAC
1 -- us2k1 trp30--------
rs573390411,2
C--113340106(+) TTGAGG/ACAGAG 1 -- us2k11Minor allele frequency- A:0.50NA 2
rs1834747031,2
C--113340184(+) TCTCGC/TGCCTC 1 -- us2k10--------
rs348650091,2
C,F--113340189(+) TGCCTC/TAACCT 1 -- us2k14Minor allele frequency- T:0.11NA WA 242
rs1145817731,2
F--113340206(+) TAGCTC/TCAGGA 1 -- us2k11Minor allele frequency- T:0.05WA 118
rs1399870181,2
--113340240(+) TGGCTA/CATTTT 1 -- us2k10--------
rs1435073871,2
--113340412(+) TATGTA/CTTTGT 1 -- us2k10--------
rs1881930011,2
--113340497(+) CTCTTC/GAGCCT 1 -- us2k10--------
rs1915428001,2
--113340592(+) GTTAAC/TTTTTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CHCHD5 (113341817 - 113346852 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for CHCHD5:    About this table     
Variant IDTypeSubtypePubMed ID
esv2720537CNV Deletion23290073
nsv874877CNV Loss21882294
nsv458997CNV Gain19166990

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CHCHD5 for disorders           About MalaCards

CHCHD5 for disorders           About GeneDecksing

Genetic Association Database (GAD): CHCHD5

Export disorders for CHCHD5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CHCHD5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CHCHD5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structural characterization of CHCHD5 and CHCHD7: two atypical human twin CX9C proteins. (PubMed id 22842048)1, 2, 3 Banci L.... Winkelmann J. (2012)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 84269 HGNC: 17840 AceView: CHCHD5 Ensembl:ENSG00000125611 euGenes: HUgn84269
ECgene: CHCHD5 H-InvDB: CHCHD5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CHCHD5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CHCHD5 gene:
Search GeneIP for patents involving CHCHD5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 inGenious Targeting Laboratory - Custom generated mouse model solutions for CHCHD5
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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