CHCHD5 Gene
protein-coding GIFtS: 38
GCID: GC02P113341
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coiled-coil-helix-coiled-coil-helix domain containing 5(Previous name: chromosome 2 open reading frame 9 )
(Previous symbol: C2orf9)
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Aliases
for CHCHD5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 51 2 | | Chromosome 2 Open Reading Frame 91 | | C2orf91 2 3 | | Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 52 | | MIC141 2 | | Mitochondrial Intermembrane Space Cysteine Motif Protein Of 14 KDa Homolog2 | | MGC111041 | | |
Export aliases for CHCHD5 gene to outside databasesPrevious GC identifers: GC02P113437 GC02P113058 GC02P105796 |
Summaries
for CHCHD5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CHCHD5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHCHD5 gene promoter:
AP-4 c-Ets-1 NF-YB CBF-A CBF-B FOXO1a CP1A NF-Y CBF(2) FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHCHD5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHCHD5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q13 Ensembl cytogenetic band: 2q13 HGNC cytogenetic band: 2q14.1CHCHD5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P113341: view genomic region
(about GC identifiers)
Start:
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113,341,817 bp from pter |
End:
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113,346,852 bp from pter |
Size:
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5,036 bases |
Orientation:
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plus strand |
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Proteins
for CHCHD5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHCH5_HUMAN, Q9BSY4 (See
protein sequence)Recommended Name: Coiled-coil-helix-coiled-coil-helix domain-containing protein 5 Size: 110 amino acids; 12395 Da
Subunit: Monomer
Subcellular location: Mitochondrion intermembrane space (Potential)
1 PDB 3D structure from  and Proteopedia  for CHCHD5:2LQL (3D)
Secondary accessions: Q585T4Explore the universe of human proteins at neXtProt for CHCHD5: NX_Q9BSY4
CHCHD5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115685.1
ENSEMBL proteins: ENSP00000325655 ENSP00000412731 ENSP00000386994
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005758 | mitochondrial intermembrane space |
IEA | -- |
CHCHD5 for ontologies About GeneDecksing
CHCHD5 Antibody Products:
Assay Products for CHCHD5: |
Protein
Domains /
Families
for CHCHD5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHCHD5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BSY4ProtoNet protein and cluster: Q9BSY4 1 Blocks protein family: IPB010625 CHCH
UniProtKB/Swiss-Prot: CHCH5_HUMAN, Q9BSY4Similarity: Contains 1 CHCH domain |
Function
for CHCHD5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHCHD5 (NM_032309) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHCHD5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD5 |
6 GenomeRNAi human phenotypes for CHCHD5:
|
Pathways & Interactions
for CHCHD5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHCHD5
|
Drugs & Compounds
for CHCHD5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CHCHD5
Search CenterWatch for drugs/clinical trials and news about CHCHD5 / CHCH5
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Transcripts
for CHCHD5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHCHD5 gene: NM_032309.2 Unigene Cluster for CHCHD5: Coiled-coil-helix-coiled-coil-helix domain containing 5 Hs.375707 [show with all ESTs]Unigene Representative Sequence: AK0246315 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000489052 ENST00000324913(uc002thz.1) ENST00000454841 ENST00000409719(uc002tia.2)
ENST00000469030
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHCHD5 (NM_032309) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHCHD5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD5 |
Additional cDNA sequence: AK024631.1 AK312219.1 BC004498.2 11 DOTS entries: DT.453478 DT.87015011 DT.95372616 DT.100780138 DT.100780140 DT.91715213 DT.97770700 DT.95372613 DT.434366 DT.91732061 DT.97845860 24/132 AceView cDNA sequences (see all 132): CR621804 CR625580 BM563093 BI522654 F03119 BM694303 AW468823 AI435438 BX380845 BU688796 BX400108 BF112002 AI885087 H09012 AI918339 BG489819 AA845436 BM423469 AI042354 AK096990 AI470555 AI749125 AI306421 F28807
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CHCHD5 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|
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| SP1: | | | | | | | - | | - | | | | - | | | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for CHCHD5
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Expression
for CHCHD5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHCHD5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCCGGCTT
About this image
See CHCHD5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHCHD5
SOURCE GeneReport for Unigene cluster: Hs.375707
SABiosciences Custom PCR Arrays for CHCHD5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHCHD5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHCHD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHCHD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHCHD5 |
Orthologs
for CHCHD5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CHCHD5 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for CHCHD5 (if available)
TreeFam Gene Tree for CHCHD5 (if available) |
Paralogs
for CHCHD5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CHCHD5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHCHD5 (113341817 - 113346852 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHCHD5: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHCHD5 |
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Disorders
/ Diseases
for CHCHD5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CHCHD5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHCHD5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CHCHD5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Structural characterization of CHCHD5 and CHCHD7: two atypical human twin CX9C proteins. (PubMed id 22842048)1, 2, 3 Banci L.... Winkelmann J. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CHCHD5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CHCHD5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHCHD5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHCHD5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHCHD5 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CHCHD5 gene:
Search GeneIP for patents involving CHCHD5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHCHD5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for CHCHD5 | | OriGene shRNA RFP for CHCHD5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHCHD5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHCHD5 | | | OriGene Protein Over-expression Lysate for CHCHD5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHCHD5 | | OriGene 3'-UTR Clone for CHCHD5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHCHD5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CHCHD5 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHCHD5 | | OriGene Custom Protein Services for CHCHD5 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHCHD5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHCHD5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHCHD5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHCHD5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHCHD5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHCHD5 |
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 | | | CHCHD5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for CHCHD5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD5 |
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