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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CHCHD4 Gene

protein-coding   GIFtS: 50
GCID: GC03M014128

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 41 2     TIMM402
MIA402 3 5     Mitochondrial Intermembrane Space Import And Assembly 40 Homolog2
Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 42 3     Mitochondrial Intermembrane Space Import And Assembly Protein 402
Mitochondrial Intermembrane Space Import And Assembly 40 Homolog (S.
Cerevisiae)1
     Translocase Of Inner Mitochondrial Membrane 40 Homolog2
Translocase Of Inner Mitochondrial Membrane 40 Homolog (S. Cerevisiae)1     CHDH45

External Ids:    HGNC: 264671   Entrez Gene: 1314742   Ensembl: ENSG000001635287   OMIM: 6110775   UniProtKB: Q8N4Q13   

Export aliases for CHCHD4 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CHCHD4 Gene:
CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved
cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 (PubMed
16185709)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CHCHD4 Gene: 
CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4) is a protein-coding gene. Diseases associated with CHCHD4 include hypoxia, and among its related super-pathways are Post-translational protein modification. GO annotations related to this gene include protein disulfide oxidoreductase activity.

UniProtKB/Swiss-Prot: MIA40_HUMAN, Q8N4Q1
Function: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as
COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial
intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form
into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with
the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an
intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized
by GFER/ERV1 via a disulfide relay system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CHCHD4 gene promoter:
         AREB6   SRF   Sp1   AML1a   HFH-1   SRF (504 AA)   HNF-3beta   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHCHD4 promoter sequence
   Search SABiosciences Chromatin IP Primers for CHCHD4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHCHD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

CHCHD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHCHD4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M014128:  view genomic region     (about GC identifiers)

Start:
14,153,577 bp from pter      End:
14,166,371 bp from pter
Size:
12,795 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MIA40_HUMAN, Q8N4Q1 (See protein sequence)
Recommended Name: Mitochondrial intermembrane space import and assembly protein 40  
Size: 142 amino acids; 15996 Da
Subunit: Monomer. Can form homooligomers. Interacts with GFER and forms transient disulfide bonds with GFER
Subcellular location: Mitochondrion intermembrane space
2 PDB 3D structures from and Proteopedia for CHCHD4:
2K3J (3D)        2L0Y (3D)    
Secondary accessions: A8K3Z9 Q96AI2 Q96MY6
Alternative splicing: 2 isoforms:  Q8N4Q1-1   Q8N4Q1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHCHD4: NX_Q8N4Q1

Explore proteomics data for CHCHD4 at MOPED 

Post-translational modifications:

  • UniProtKB: Forms intrachain disulfide bridges, but exists in different redox states
  • View neXtProt modification sites for NX_Q8N4Q1

  • CHCHD4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CHCHD4 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001091972.1  NP_653237.1  

    ENSEMBL proteins: 
     ENSP00000295767   ENSP00000380122   ENSP00000402716  
    Reactome Protein details: Q8N4Q1
    Human Recombinant Protein Products for CHCHD4: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for CHCHD4 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005758mitochondrial intermembrane space IDA16185709

    CHCHD4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CHCHD: Coiled-coil-helix-coiled-coil-helix domain containing

    1 InterPro protein domain:
     IPR010625 CHCH

    Graphical View of Domain Structure for InterPro Entry Q8N4Q1

    ProtoNet protein and cluster: Q8N4Q1

    UniProtKB/Swiss-Prot: MIA40_HUMAN, Q8N4Q1
    Domain: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of
    MIA40 in mitochondria (Probable)
    Similarity: Contains 1 CHCH domain


    CHCHD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIA40_HUMAN, Q8N4Q1
    Function: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as
    COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial
    intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form
    into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with
    the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an
    intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized
    by GFER/ERV1 via a disulfide relay system

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015035protein disulfide oxidoreductase activity IMP19182799
         
    CHCHD4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHCHD4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CHCHD4 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHCHD4 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CHCHD4:
    hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHCHD4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHCHD4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CHCHD4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2        Reactome Pathways for CHCHD4
        Mitochondrial Protein Import
    Metabolism of proteins



    CHCHD4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHCHD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/19 Interacting proteins for CHCHD4 (Q8N4Q13 ENSP000002957674) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIAPIN1Q6FI813, ENSP000003779144I2D: score=1 STRING: ENSP00000377914
    PRKAB2O437413I2D: score=1 
    COX17ENSP000002610704STRING: ENSP00000261070
    TOMM20ENSP000003555664STRING: ENSP00000355566
    TOMM22ENSP000002160344STRING: ENSP00000216034
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0022417protein maturation by protein folding IMP--
    GO:0044267cellular protein metabolic process TAS--
    GO:0045041protein import into mitochondrial intermembrane space IMP16185709
    GO:0051084'de novo' posttranslational protein folding IMP--

    CHCHD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CHCHD4 (MIA40)

    Search CenterWatch for drugs/clinical trials and news about CHCHD4 / MIA40

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CHCHD4 gene (2 alternative transcripts): 
    NM_001098502.1  NM_144636.2  

    Unigene Cluster for CHCHD4:

    Coiled-coil-helix-coiled-coil-helix domain containing 4
    Hs.517815  [show with all ESTs]
    Unigene Representative Sequence: NM_144636
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295767(uc003byi.4 uc003byj.4) ENST00000396914 ENST00000420103

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CHCHD4:
    hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHCHD4 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHCHD4
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    Additional mRNA sequence: 

    AK056271.1 AK290764.1 BC017082.1 BC033775.1 

    5 DOTS entries:

    DT.40122565  DT.100779146  DT.100719274  DT.65286937  DT.95176755 

    24/71 AceView cDNA sequences (see all 71):

    CB116773 CR598522 CR618638 BG036838 AW245705 BG117561 AA633382 AL568974 
    BE856452 BM467480 NM_144636 CR598357 BF726085 BC017082 CR596652 BM840196 
    CR604058 AK056271 BU942404 BU849306 BQ214854 BU186563 BE890027 AI797699 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CHCHD4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:                          -                           
    SP3:                    -     -                           


    ECgene alternative splicing isoforms for CHCHD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CHCHD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCTACCT
    CHCHD4 Expression
    About this image


    See CHCHD4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CHCHD4

    SOURCE GeneReport for Unigene cluster: Hs.517815

    UniProtKB/Swiss-Prot: MIA40_HUMAN, Q8N4Q1
    Tissue specificity: Expressed in all tissues tested, suggesting an ubiquitous expression

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHCHD4 gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chchd41 , 5 coiled-coil-helix-coiled-coil-helix domain containing more1, 5 83.21(n)1
    87.77(a)1
      6 (40.53 cM)5
    721701  NM_133928.21  NP_598689.11 
     914642765 
    chicken
    (Gallus gallus)
    Aves CHCHD41 coiled-coil-helix-coiled-coil-helix domain containing more 75.85(n)
    86.23(a)
      416037  NM_001113759.1  NP_001107231.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHCHD46
    Uncharacterized protein
    78(a)
    1 ↔ 1
    2(169396645-169402464)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.295302 Xenopus laevis transcribed sequence with weak similarity more 80.22(n)    BU908037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chchd41 coiled-coil-helix-coiled-coil-helix domain containing more 76.79(n)
    84.82(a)
      445144  NM_001003538.1  NP_001003538.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG343171 CG34317 60.55(n)
    55.96(a)
      5740224  NM_143513.2  NP_651770.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK616.26
    ZK616.36
    (see all 4)
    Protein ZK616.3
    (see all 4)
    29(a)
    26(a)
    (see all 4)
    many → 1
    many → 1
    (see all 4)
    IV(5397837-5398589)
    IV(5397097-5397744)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MIA40(YKL195W)4 Essential protein of the mitochondrial intermembrane more   --   11(75821-77032) 853639  NP_012726.2 


    ENSEMBL Gene Tree for CHCHD4 (if available)
    TreeFam Gene Tree for CHCHD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CHCHD4 gene

    CHCHD4 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for CHCHD4
    PGOHUM00000245287 PGOHUM00000237531 PGOHUM00000233469 PGOHUM00000236305 PGOHUM00000236455


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/230 SNPs in CHCHD4 are shown (see all 230)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27313171,2
    C,F,A,H--14153194(-) GCTTAT/CCTGGG 2 -- int115Minor allele frequency- C:0.36NS EA NA WA CSA 766
    rs1391277181,2
    --14153216(+) TCCTCA/GTTTCA 2 -- int10--------
    rs1998162561,2
    C--14153243(+) GGCAAC/TTTTTT 2 -- int10--------
    rs1413684591,2
    --14153266(+) TAACAC/TATTTG 2 -- int10--------
    rs1469777421,2
    --14153377(+) TAGACA/TAACTG 2 -- int10--------
    rs1867790641,2
    --14153476(+) GTTTAA/CCAATA 2 -- int10--------
    rs731405951,2
    C,F--14153533(+) TTATAT/AAGAAA 2 -- int12Minor allele frequency- A:0.08WA 120
    rs11331181,2
    C--14153777(-) CCTTTC/TTAAGT 2 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs1488759191,2
    C--14153818(+) CATCC-/AAA   
      CACAGA
    AAACC
    2 -- cds10--------
    rs38144121,2
    C,F--14153844(+) CAACAC/GCTACA 2 -- ut311Minor allele frequency- G:0.04EA 120

    HapMap Linkage Disequilibrium report for CHCHD4 (14153577 - 14166371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CHCHD4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv3573CNV Deletion18987735
    esv2724947CNV Deletion23290073
    esv2724945CNV Deletion23290073
    nsv876550CNV Loss21882294
    esv34163CNV Loss18971310

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611077    OMIM disorders: --

    2 diseases for CHCHD4:    About MalaCards
    hypoxia    


    CHCHD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHCHD4
    Human Genome Epidemiology (HuGE) Navigator: CHCHD4 (1 document)

    Export disorders for CHCHD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CHCHD4 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with CHCHD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40. (PubMed id 23186364)1, 2 Sztolsztener M.E.... Chacinska A. (2013)
    2. Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia si gnaling and tumor progression. (PubMed id 22214851)1, 3 Yang J....Ashcroft M. (2012)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria. (PubMed id 19182799)1, 2 Banci L.... Tokatlidis K. (2009)
    5. Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space. (PubMed id 16185709)1, 2 Hofmann S....Bauer M.F. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (2013)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 131474 HGNC: 26467 AceView: CHCHD4 Ensembl:ENSG00000163528 euGenes: HUgn131474
    ECgene: CHCHD4 H-InvDB: CHCHD4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CHCHD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CHCHD4 gene:
    Search GeneIP for patents involving CHCHD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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