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CHCHD4 Gene

protein-coding   GIFtS: 51
GCID: GC03M014153

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 41 2     TIMM402
MIA402 3 5     Mitochondrial Intermembrane Space Import And Assembly 40 Homolog2
Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 42 3     Mitochondrial Intermembrane Space Import And Assembly Protein 402
Mitochondrial Intermembrane Space Import And Assembly 40 Homolog (S.
Cerevisiae)1
     Translocase Of Inner Mitochondrial Membrane 40 Homolog2
Translocase Of Inner Mitochondrial Membrane 40 Homolog (S. Cerevisiae)1     CHDH45

External Ids:    HGNC: 264671   Entrez Gene: 1314742   Ensembl: ENSG000001635287   OMIM: 6110775   UniProtKB: Q8N4Q13   

Export aliases for CHCHD4 gene to outside databases

Previous GC identifer: GC03M014128


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHCHD4 Gene:
CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved
cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 (PubMed
16185709)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CHCHD4 Gene:
CHCHD4 (coiled-coil-helix-coiled-coil-helix domain containing 4) is a protein-coding gene. Diseases associated with CHCHD4 include hypoxia, and malaria. GO annotations related to this gene include protein disulfide oxidoreductase activity.

UniProtKB/Swiss-Prot: MIA40_HUMAN, Q8N4Q1
Function: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as
COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial
intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form
into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with
the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an
intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized
by GFER/ERV1 via a disulfide relay system




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHCHD4 gene promoter:
         AREB6   SRF   Sp1   AML1a   HFH-1   SRF (504 AA)   HNF-3beta   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHCHD4 promoter sequence
   Search Chromatin IP Primers for CHCHD4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHCHD4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.1   Ensembl cytogenetic band:  3p25.1   HGNC cytogenetic band: 3p25.1

CHCHD4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHCHD4 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M014153:  view genomic region     (about GC identifiers)

Start:
14,153,577 bp from pter      End:
14,166,371 bp from pter
Size:
12,795 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MIA40_HUMAN, Q8N4Q1 (See protein sequence)
Recommended Name: Mitochondrial intermembrane space import and assembly protein 40  
Size: 142 amino acids; 15996 Da
Subunit: Monomer. Can form homooligomers. Interacts with GFER and forms transient disulfide bonds with GFER
2 PDB 3D structures from and Proteopedia for CHCHD4:
2K3J (3D)        2L0Y (3D)    
Secondary accessions: A8K3Z9 Q96AI2 Q96MY6
Alternative splicing: 2 isoforms:  Q8N4Q1-1   Q8N4Q1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CHCHD4: NX_Q8N4Q1

Explore proteomics data for CHCHD4 at MOPED

Post-translational modifications: 

  • Forms intrachain disulfide bridges, but exists in different redox states1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CHCHD4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001091972.1  NP_653237.1  

    ENSEMBL proteins: 
     ENSP00000295767   ENSP00000380122   ENSP00000402716  
    Reactome Protein details: Q8N4Q1

    CHCHD4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHCHD: Coiled-coil-helix-coiled-coil-helix domain containing

    1 InterPro protein domain:
     IPR010625 CHCH

    Graphical View of Domain Structure for InterPro Entry Q8N4Q1

    ProtoNet protein and cluster: Q8N4Q1

    UniProtKB/Swiss-Prot: MIA40_HUMAN, Q8N4Q1
    Domain: The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of
    MIA40 in mitochondria (Probable)
    Similarity: Contains 1 CHCH domain


    CHCHD4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MIA40_HUMAN, Q8N4Q1
    Function: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as
    COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial
    intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form
    into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with
    the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an
    intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized
    by GFER/ERV1 via a disulfide relay system

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015035protein disulfide oxidoreductase activity IMP19182799
         
    CHCHD4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CHCHD4:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHCHD4
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    miRNA
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    miRTarBase miRNAs that target CHCHD4:
    hsa-mir-378a-3p (MIRT043892)

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    1 qRT-PCR Assays for microRNA that regulate CHCHD4:
    hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHCHD4 3' UTR sequence
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MIA40_HUMAN, Q8N4Q1: Mitochondrion intermembrane space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3
    extracellular2
    golgi apparatus1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005758mitochondrial intermembrane space IDA16185709

    CHCHD4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHCHD4 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    2Mitochondrial Protein Import
    Mitochondrial Protein Import

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CHCHD4
        Mitochondrial protein import



    CHCHD4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHCHD4
    Interactions:

        Search GeneGlobe Interaction Network for CHCHD4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHCHD4 (Q8N4Q13 ENSP000002957674) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CIAPIN1Q6FI813, ENSP000003779144I2D: score=1 STRING: ENSP00000377914
    PRKAB2O437413I2D: score=1 
    COX17ENSP000002610704STRING: ENSP00000261070
    TOMM20ENSP000003555664STRING: ENSP00000355566
    TOMM22ENSP000002160344STRING: ENSP00000216034
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006626protein targeting to mitochondrion TAS--
    GO:0022417protein maturation by protein folding IMP--
    GO:0044267cellular protein metabolic process TAS--
    GO:0045041protein import into mitochondrial intermembrane space IMP16185709
    GO:0051084'de novo' posttranslational protein folding IMP--

    CHCHD4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHCHD4 (MIA40)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CHCHD4 gene (2 alternative transcripts): 
    NM_001098502.1  NM_144636.2  

    Unigene Cluster for CHCHD4:

    Coiled-coil-helix-coiled-coil-helix domain containing 4
    Hs.517815  [show with all ESTs]
    Unigene Representative Sequence: NM_144636
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000295767(uc003byi.4 uc003byj.4) ENST00000396914 ENST00000420103

    miRNA
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    Block miRNA regulation of human, mouse, rat CHCHD4 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CHCHD4:
    hsa-miR-628-5p
    SwitchGear 3'UTR luciferase reporter plasmidCHCHD4 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CHCHD4
      QuantiFast Probe-based Assays in human, mouse, rat CHCHD4

    Additional mRNA sequence: 

    AK056271.1 AK290764.1 BC017082.1 BC033775.1 

    5 DOTS entries:

    DT.40122565  DT.100779146  DT.100719274  DT.65286937  DT.95176755 

    Selected AceView cDNA sequences (see all 71):

    AA633382 CR596652 CR598522 NM_144636 BC017082 AW245705 AK056271 BF726085 
    BE856452 CB116773 BM840196 BM467480 CR618638 CR604058 CR598357 AL568974 
    BG036838 BG117561 BG110476 AW005986 BX406943 BX279819 BU849306 BG392290 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for CHCHD4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                                      
    SP2:                          -                           
    SP3:                    -     -                           


    ECgene alternative splicing isoforms for CHCHD4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHCHD4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTCTACCT
    CHCHD4 Expression
    About this image

    CHCHD4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHCHD4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517815

    UniProtKB/Swiss-Prot: MIA40_HUMAN, Q8N4Q1
    Tissue specificity: Expressed in all tissues tested, suggesting an ubiquitous expression

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHCHD4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chchd41 , 5 coiled-coil-helix-coiled-coil-helix domain containing more1, 5 83.69(n)1
    86.33(a)1
      6 (40.53 cM)5
    721701  NM_133928.21  NP_598689.11 
     914642765 
    chicken
    (Gallus gallus)
    Aves CHCHD41 coiled-coil-helix-coiled-coil-helix domain containing more 76.09(n)
    84.06(a)
      416037  NM_001113759.1  NP_001107231.1 
    lizard
    (Anolis carolinensis)
    Reptilia CHCHD46
    coiled-coil-helix-coiled-coil-helix domain contain...
    76(a)
    1 ↔ 1
    2(169396645-169402464)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.295302 Xenopus laevis transcribed sequence with weak similarity more 80.22(n)    BU908037.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chchd41 coiled-coil-helix-coiled-coil-helix domain containing more 77.57(n)
    86.92(a)
      445144  NM_001003538.1  NP_001003538.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG79501 CG7950 61(n)
    60(a)
      43579  NM_143513.3  NP_651770.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MIA40(YKL195W)4 Essential protein of the mitochondrial intermembrane more   --   11(75821-77032) 853639  NP_012726.2 


    ENSEMBL Gene Tree for CHCHD4 (if available)
    TreeFam Gene Tree for CHCHD4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHCHD4 gene

    CHCHD4 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for CHCHD4
    PGOHUM00000245287 PGOHUM00000237531 PGOHUM00000233469 PGOHUM00000236305 PGOHUM00000236455


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHCHD4 (see all 230)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs27313171,2
    C,F,A,H--14153194(-) GCTTAT/CCTGGG 2 -- int115Minor allele frequency- C:0.36NS EA NA WA CSA 766
    rs1391277181,2
    --14153216(+) TCCTCA/GTTTCA 2 -- int10--------
    rs1998162561,2
    C--14153243(+) GGCAAC/TTTTTT 2 -- int10--------
    rs1413684591,2
    --14153266(+) TAACAC/TATTTG 2 -- int10--------
    rs1469777421,2
    --14153377(+) TAGACA/TAACTG 2 -- int10--------
    rs1867790641,2
    --14153476(+) GTTTAA/CCAATA 2 -- int10--------
    rs731405951,2
    C,F--14153533(+) TTATAT/AAGAAA 2 -- int12Minor allele frequency- A:0.08WA 120
    rs11331181,2
    C--14153777(-) CCTTTC/TTAAGT 2 -- ut313Minor allele frequency- T:0.00MN NA 188
    rs1488759191,2
    C--14153818(+) CATCC-/AAA   
      CACAGA
    AAACC
    2 -- cds10--------
    rs38144121,2
    C,F--14153844(+) CAACAC/GCTACA 2 -- ut311Minor allele frequency- G:0.04EA 120

    HapMap Linkage Disequilibrium report for CHCHD4 (14153577 - 14166371 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CHCHD4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv3573CNV Deletion18987735
    esv2724947CNV Deletion23290073
    esv2724945CNV Deletion23290073
    nsv876550CNV Loss21882294
    esv34163CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611077    OMIM disorders: --

    2 diseases for CHCHD4:    
    About MalaCards
    hypoxia    malaria


    CHCHD4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CHCHD4
    Human Genome Epidemiology (HuGE) Navigator: CHCHD4 (1 document)

    Export disorders for CHCHD4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHCHD4 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CHCHD4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Disulfide bond formation: sulfhydryl oxidase ALR controls mitochondrial biogenesis of human MIA40. (PubMed id 23186364)1, 2 Sztolsztener M.E.... Chacinska A. (Traffic 2013)
    2. Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression. (PubMed id 22214851)1, 3 Yang J....Ashcroft M. (J. Clin. Invest. 2012)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria. (PubMed id 19182799)1, 2 Banci L.... Tokatlidis K. (Nat. Struct. Mol. Biol. 2009)
    5. Functional and mutational characterization of human MIA40 acting during import into the mitochondrial intermembrane space. (PubMed id 16185709)1, 2 Hofmann S....Bauer M.F. (J. Mol. Biol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells. (PubMed id 23676665)1 Fischer M....Riemer J. (Mol. Biol. Cell 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131474 HGNC: 26467 AceView: CHCHD4 Ensembl:ENSG00000163528 euGenes: HUgn131474
    ECgene: CHCHD4 H-InvDB: CHCHD4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHCHD4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHCHD4 gene:
    Search GeneIP for patents involving CHCHD4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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