Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CHCHD2 Gene

protein-coding   GIFtS: 53
GCID: GC07M056171

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2

(Previous name: chromosome 7 open reading frame 17)
(Previous symbol: C7orf17)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 21 2     HCV NS2 Trans-Regulated Protein2 3
C7orf171 2 3     Chromosome 7 Open Reading Frame 171
Aging-Associated Gene 10 Protein2 3     16.7kD Protein2
NS2TP2 3     Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 2,
Mitochondrial2

External Ids:    HGNC: 216451   Entrez Gene: 511422   Ensembl: ENSG000001061537   UniProtKB: Q9Y6H13   

Export aliases for CHCHD2 gene to outside databases

Previous GC identifers: GC07M055911 GC07M055943 GC07M056136 GC07M055983


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for CHCHD2 Gene:
CHCHD2 (coiled-coil-helix-coiled-coil-helix domain containing 2) is a protein-coding gene. Diseases associated with CHCHD2 include fanconi's anemia, and malaria. An important paralog of this gene is CHCHD10.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHCHD2 gene promoter:
         FOXF2   Pax-5   NRSF form 1   HEN1   CP2   FOXO4   SEF-1 (1)   NF-Y   CBF(2)   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHCHD2 promoter sequence
   Search Chromatin IP Primers for CHCHD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHCHD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11.2   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11.2

CHCHD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHCHD2 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M056171:  view genomic region     (about GC identifiers)

Start:
56,169,262 bp from pter      End:
56,174,269 bp from pter
Size:
5,008 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 56,173,513-56,178,434     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CHCH2_HUMAN, Q9Y6H1 (See protein sequence)
Recommended Name: Coiled-coil-helix-coiled-coil-helix domain-containing protein 2, mitochondrial precursor  
Size: 151 amino acids; 15513 Da
Secondary accessions: Q498C3 Q6NZ50

Explore the universe of human proteins at neXtProt for CHCHD2: NX_Q9Y6H1

Explore proteomics data for CHCHD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CHCHD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057223.1  
    ENSEMBL proteins: 
     ENSP00000378812  

    CHCHD2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CHCHD2
    GenScript Custom Purified and Recombinant Proteins Services for CHCHD2
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CHCHD2

    CHCHD2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CHCHD2
    Novus Biologicals CHCHD2 Antibody
    Abcam antibodies for CHCHD2
    Cloud-Clone Corp. Antibodies for CHCHD2
    ThermoFisher Antibody for CHCHD2
    LSBio Antibodies in human, mouse, rat for CHCHD2

    CHCHD2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CHCHD2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CHCHD2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CHCHD2
    Cloud-Clone Corp. CLIAs for CHCHD2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CHCHD: Coiled-coil-helix-coiled-coil-helix domain containing

    1 InterPro protein domain:
     IPR010625 CHCH

    Graphical View of Domain Structure for InterPro Entry Q9Y6H1

    ProtoNet protein and cluster: Q9Y6H1

    1 Blocks protein domain: IPB010625 CHCH

    UniProtKB/Swiss-Prot: CHCH2_HUMAN, Q9Y6H1
    Similarity: Contains 1 CHCH domain


    CHCHD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Phenotypes:
         1 GenomeRNAi human phenotype for CHCHD2:
     Decreased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHCHD2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHCHD2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CHCHD2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CHCHD2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CHCHD2:
    hsa-mir-320b (MIRT036209), hsa-mir-1229-3p (MIRT036288), hsa-mir-484 (MIRT041949), hsa-mir-92a-3p (MIRT049175), hsa-mir-221-3p (MIRT046923)

    Block miRNA regulation of human, mouse, rat CHCHD2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CHCHD2
    SwitchGear 3'UTR luciferase reporter plasmidCHCHD2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CHCHD2
    Predesigned siRNA for gene silencing in human, mouse, rat CHCHD2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CHCHD2

    Clone
    Products:
         
    OriGene clones in human, mouse for CHCHD2 (see all 7)
    OriGene ORF clones in mouse, rat for CHCHD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHCHD2 (NM_016139)
    Sino Biological Human cDNA Clone for CHCHD2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHCHD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CHCHD2
    Browse ESI BIO Cell Lines and PureStem Progenitors for CHCHD2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHCHD2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CHCH2_HUMAN, Q9Y6H1: Mitochondrion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    nucleus2
    cytosol1
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    CHCHD2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHCHD2
    Interactions:

        Search GeneGlobe Interaction Network for CHCHD2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CHCHD2 (Q9Y6H13 ENSP000003788124) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT1Q96EB63, ENSP000002120154I2D: score=2 STRING: ENSP00000212015
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    TAF12Q165143I2D: score=5 
    YBX1ENSP000003616264STRING: ENSP00000361626
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHCHD2 (CHCH2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CHCHD2 gene: 
    NM_016139.2  

    Unigene Clusters for CHCHD2:

    Coiled-coil-helix-coiled-coil-helix domain containing 2
    Hs.389996  [show with all ESTs], Hs.547257  [show with all ESTs]
    Unigene Representative Sequences: BM553650, BM471068
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395422(uc003tsa.3) ENST00000473095

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CHCHD2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CHCHD2
    SwitchGear 3'UTR luciferase reporter plasmidCHCHD2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CHCHD2
    Predesigned siRNA for gene silencing in human, mouse, rat CHCHD2
    Clone
    Products:
         
    OriGene clones in human, mouse for CHCHD2 (see all 7)
    OriGene ORF clones in mouse, rat for CHCHD2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CHCHD2 (NM_016139)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CHCHD2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CHCHD2
    OriGene qSTAR qPCR primer pairs in human, mouse for CHCHD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHCHD2
      QuantiTect SYBR Green Assays in human, mouse, rat CHCHD2
      QuantiFast Probe-based Assays in human, mouse, rat CHCHD2

    Additional mRNA sequence: 

    AY605046.1 AY633613.1 

    Selected DOTS entries (see all 37):

    DT.95292050  DT.95305151  DT.100679363  DT.100679366  DT.100679371  DT.120353  DT.87016294  DT.100679360 
    DT.99942367  DT.97862629  DT.92462189  DT.121122232  DT.121122293  DT.121354687  DT.121148236  DT.121122252 
    DT.121122239  DT.100679372  DT.87003640  DT.95291985  DT.95292053  DT.100039455  DT.100679367  DT.121122385 

    Selected AceView cDNA sequences (see all 1150):

    BM831650 BM312401 CA843130 AW405648 BM756638 CA943066 AW196833 BX099536 
    AA132204 CR603585 AJ712452 AA928308 BM831952 AA083578 BU838808 BQ632406 
    BU950012 BQ431563 CA843089 CB069471 CA942837 BM836054 CA776909 BM784755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CHCHD2 expression in normal human tissues (normalized intensities)      CHCHD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCTCCGG
    CHCHD2 Expression
    About this image


    CHCHD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Primary Oocyte Primary Follicle
     
     Gonad
             Primary Oocyte Primary Follicle
    CHCHD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHCHD2 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.389996 Hs.547257
        Custom PCR Arrays for CHCHD2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CHCHD2
    OriGene qSTAR qPCR primer pairs in human, mouse for CHCHD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHCHD2
    QuantiTect SYBR Green Assays in human, mouse, rat CHCHD2
    QuantiFast Probe-based Assays in human, mouse, rat CHCHD2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHCHD2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CHCHD2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chchd21 , 5 coiled-coil-helix-coiled-coil-helix domain containing more1, 5 83.11(n)1
    86.67(a)1
      5 (68.26 cM)5
    140041  NM_024166.61  NP_077128.21 
     1298811565 
    chicken
    (Gallus gallus)
    Aves CHCHD21 coiled-coil-helix-coiled-coil-helix domain containing more 75.66(n)
    77.78(a)
      417544  NM_001006218.1  NP_001006218.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia 480430002   -- 75.04(n)    48043000 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc732662 hypothetical protein MGC73266 75.18(n)   393740  BC059598.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50101 CG5010 61.22(n)
    54.08(a)
      32701  NM_132968.1  NP_573196.1 
    worm
    (Caenorhabditis elegans)
    Secernentea har-16
    Protein HAR-1 (har-1) mRNA, complete cds
    44(a)
    1 → many
    III(4152054-4152912) WBGene00007630
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MIC176
    Mitochondrial intermembrane space protein, require...
    35(a)
    1 → many
    XIII(272193-272663) YMR002W


    ENSEMBL Gene Tree for CHCHD2 (if available)
    TreeFam Gene Tree for CHCHD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CHCHD2 gene
    CHCHD102  
    2 SIMAP similar genes for CHCHD2 using alignment to 1 protein entry:     CHCH2_HUMAN:
    CHCHD2P9    CHCHD10

    CHCHD2 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for CHCHD2 (see all 13)
    PGOHUM00000248386 PGOHUM00000248553 PGOHUM00000234662 PGOHUM00000244108 PGOHUM00000244613


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CHCHD2 (see all 181)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407027141,2
    --56168797(+) CAAGCC/TTGCTT 1 -- int10--------
    rs1497038701,2
    --56169013(+) TTCTCC/TCGCCT 1 -- int10--------
    rs1127709581,2
    C,F--56169014(+) TCTCCA/CGCCTC 1 -- int11Minor allele frequency- C:0.00CSA 1
    rs132345041,2
    C--56169135(+) GCAGCT/CAGAAC 1 -- int15Minor allele frequency- C:0.03NA EA 394
    rs1899553091,2
    --56169181(+) GCTACA/TCCTTA 1 -- int10--------
    rs1933008791,2
    --56169182(+) CTACTC/GCTTAT 1 -- int10--------
    rs1847355581,2
    C--56169213(+) CAGATC/TTGGGA 1 -- int10--------
    rs1455053311,2
    C--56169246(+) GACTAC/TAGACT 1 -- int10--------
    rs1488847341,2
    --56169358(+) GCCCAA/GTCCCA 1 -- ut310--------
    rs84061,2
    C,F,A,H--56169419(-) TTCCTA/GGCTTC 1 -- ut31 ese324Minor allele frequency- G:0.21MN NS EA NA WA CSA 1563

    HapMap Linkage Disequilibrium report for CHCHD2 (56169262 - 56174269 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CHCHD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734447CNV Deletion23290073
    esv2734448CNV Deletion23290073
    dgv1201e199CNV Deletion23128226
    nsv526294CNV Gain19592680
    esv28230CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHCHD2
    DNA2.0 Custom Variant and Variant Library Synthesis for CHCHD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    3 diseases for CHCHD2:    About MalaCards
    fanconi's anemia    malaria    thyroiditis


    CHCHD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): CHCHD2
    Human Genome Epidemiology (HuGE) Navigator: CHCHD2 (1 document)

    Export disorders for CHCHD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CHCHD2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with CHCHD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (Blood 2009)
    8. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. (PubMed id 19343720)1 Law I.K....Wang Y. (Proteomics 2009)
    9. A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis. (PubMed id 19680543)1 Baughman J.M....Mootha V.K. (PLoS Genet. 2009)
    10. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. (PubMed id 17500595)1 Kaltenbach L.S....Hughes R.E. (PLoS Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51142 HGNC: 21645 AceView: CHCHD2 Ensembl:ENSG00000106153 euGenes: HUgn51142
    ECgene: CHCHD2 H-InvDB: CHCHD2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CHCHD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CHCHD2 gene:
    Search GeneIP for patents involving CHCHD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CHCHD2  
     OriGene qPCR primer pairs and template standards for CHCHD2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CHCHD2  
     OriGene qSTAR qPCR primer pairs in human, mouse for CHCHD2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CHCHD2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CHCHD2   OriGene Custom Protein Services for CHCHD2  

     
     
     Block miRNA regulation of human, mouse, rat CHCHD2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CHCHD2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHCHD2 Predesigned siRNA for gene silencing in human, mouse, rat CHCHD2
     QuantiFast Probe-based Assays in human, mouse, rat CHCHD2 QuantiTect SYBR Green Assays in human, mouse, rat CHCHD2
     Custom PCR Arrays for CHCHD2 Search Chromatin IP Primers for CHCHD2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHCHD2  Search GeneGlobe Interaction Network for CHCHD2
     Regulatory tfbs in CHCHD2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CHCHD2 GenScript cDNA clones with any tag delivered in your preferred vector for CHCHD2
     GenScript Custom Assay Services for CHCHD2 GenScript Custom overexpressing Cell Line Services for CHCHD2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CHCHD2 (CHCH2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CHCHD2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CHCHD2 antibodies
     Antibodies for CHCHD2
     See all of Abcam's Antibodies, Kits and Proteins for CHCHD2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CHCHD2
     Antibodies for CHCHD2
     ELISAs for CHCHD2
     CLIAs for CHCHD2



     Browse ESI BIO Cell Lines and PureStem Progenitors for CHCHD2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHCHD2
     SwitchGear 3'UTR luciferase reporter plasmids for CHCHD2
     SwitchGear Promoter luciferase reporter plasmids for CHCHD2
     ThermoFisher Antibody for CHCHD2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHCHD2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CHCHD2
     LSBio Antibodies in human, mouse, rat for CHCHD2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CHCHD2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4