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CHCHD1 Gene

protein-coding   GIFtS: 48
GCID: GC10P075541

Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 1

(Previous name: chromosome 10 open reading frame 34)
(Previous symbol: C10orf34)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 11 2     Chromosome 10 Open Reading Frame 341
C10orf341 2 3     C23602
Nuclear Protein C23602 3     Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 12
28S Ribosomal Protein S37, Mitochondrial2 3     MRPS373
MRP-S372 3     

External Ids:    HGNC: 235181   Entrez Gene: 1184872   Ensembl: ENSG000001725867   OMIM: 6088425   UniProtKB: Q96BP23   

Export aliases for CHCHD1 gene to outside databases

Previous GC identifers: GC10P074887 GC10P075211 GC10P069537


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CHCHD1 Gene:
CHCHD1 (coiled-coil-helix-coiled-coil-helix domain containing 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHCHD1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   NF-kappaB   E2F   E2F-1   USF-1   COMP1   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHCHD1 promoter sequence
   Search Chromatin IP Primers for CHCHD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHCHD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q22.2   Ensembl cytogenetic band:  10q22.2   HGNC cytogenetic band: 10q22.3

CHCHD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHCHD1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P075541:  view genomic region     (about GC identifiers)

Start:
75,541,805 bp from pter      End:
75,543,410 bp from pter
Size:
1,606 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CHCH1_HUMAN, Q96BP2 (See protein sequence)
Recommended Name: Coiled-coil-helix-coiled-coil-helix domain-containing protein 1  
Size: 118 amino acids; 13475 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins

Explore the universe of human proteins at neXtProt for CHCHD1: NX_Q96BP2

Explore proteomics data for CHCHD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys106
  • Modification sites at PhosphoSitePlus

  • See CHCHD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_976043.1  
    ENSEMBL proteins: 
     ENSP00000361928   ENSP00000361923  

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    Cloud-Clone Corp. Proteins for CHCHD1

     
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    antibodies-online proteins for CHCHD1 (2 products) 

     
    antibodies-online peptides for CHCHD1

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    antibodies-online antibodies for CHCHD1 (9 products) 

    CHCHD1 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CHCHD: Coiled-coil-helix-coiled-coil-helix domain containing

    2 InterPro protein domains:
     IPR010625 CHCH
     IPR009069 Cys_alpha_HP_mot_SF

    Graphical View of Domain Structure for InterPro Entry Q96BP2

    ProtoNet protein and cluster: Q96BP2

    UniProtKB/Swiss-Prot: CHCH1_HUMAN, Q96BP2
    Similarity: Contains 1 CHCH domain


    Find genes that share domains with CHCHD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CHCHD1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CHCHD1

    miRNA
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    Block miRNA regulation of human, mouse, rat CHCHD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHCHD1 (see all 9):
    hsa-miR-19b-2* hsa-miR-522 hsa-miR-3065-5p hsa-miR-3647-3p hsa-miR-224* hsa-miR-105 hsa-miR-19b-1* hsa-miR-19a*
    SwitchGear 3'UTR luciferase reporter plasmidCHCHD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CHCHD1

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    GenScript: all cDNA clones in your preferred vector: CHCHD1 (NM_203298)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHCHD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CHCH1_HUMAN, Q96BP2: Mitochondrion. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol3
    extracellular2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with CHCHD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHCHD1
    Interactions:

        Search GeneGlobe Interaction Network for CHCHD1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for CHCHD1 (Q96BP21, 2, 3 ENSP000003619234) via UniProtKB, MINT, STRING, and/or I2D (see all 244)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    ACAD9Q9H8452MINT-8079030
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHCHD1 (CHCH1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHCHD1 gene: 
    NM_203298.2  

    Unigene Cluster for CHCHD1:

    Coiled-coil-helix-coiled-coil-helix domain containing 1
    Hs.181174  [show with all ESTs]
    Unigene Representative Sequence: BM924828
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372837(uc001jvb.2) ENST00000372833(uc001jvc.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CHCHD1 (see all 9):
    hsa-miR-19b-2* hsa-miR-522 hsa-miR-3065-5p hsa-miR-3647-3p hsa-miR-224* hsa-miR-105 hsa-miR-19b-1* hsa-miR-19a*
    SwitchGear 3'UTR luciferase reporter plasmidCHCHD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CHCHD1
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHCHD1
    Primer
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    OriGene qPCR primer pairs and template standards for CHCHD1
    OriGene qSTAR qPCR primer pairs in human, mouse for CHCHD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CHCHD1
      QuantiTect SYBR Green Assays in human, mouse, rat CHCHD1
      QuantiFast Probe-based Assays in human, mouse, rat CHCHD1

    Additional mRNA sequence: 

    AK098720.1 BC015387.1 BC020852.1 

    4 DOTS entries:

    DT.453339  DT.101970431  DT.40124886  DT.100782586 

    Selected AceView cDNA sequences (see all 77):

    BM790198 BM980667 AA628654 BM129025 AI202556 BU678119 AI354326 BC015387 
    BQ129967 CD105257 AI992290 CR603253 AI827814 AA306748 CK905781 BF061723 
    NM_203298 CF130308 BM788534 BM787401 BX375070 AW188368 AK098720 BU508253 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CHCHD1    About this scheme

    ExUns: 1 ^ 2 ^ 3
    SP1:                  
    SP2:                  


    ECgene alternative splicing isoforms for CHCHD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHCHD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCTTTGG
    CHCHD1 Expression
    About this image

    CHCHD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHCHD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.181174
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CHCHD1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chchd11 , 5 coiled-coil-helix-coiled-coil-helix domain containing more1, 5 82.62(n)1
    83.76(a)1
      14 (11.53 cM)5
    661211  NM_025366.31  NP_079642.11 
     207030275 
    chicken
    (Gallus gallus)
    Aves CHCHD11 coiled-coil-helix-coiled-coil-helix domain containing more 58.08(n)
    52.58(a)
      423741  XM_421616.4  XP_421616.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHCHD16
    coiled-coil-helix-coiled-coil-helix domain contain...
    61(a)
    1 ↔ 1
    GL343196.1(1301525-1302818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.184722 Xenopus laevis transcribed sequence with strong similarity more 83.69(n)    BG347832.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chchd11 coiled-coil-helix-coiled-coil-helix domain containing more 53.05(n)
    49.46(a)
      557606  NM_001082814.1  NP_001076283.1 


    ENSEMBL Gene Tree for CHCHD1 (if available)
    TreeFam Gene Tree for CHCHD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHCHD1 gene

    Find genes that share paralogs with CHCHD1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CHCHD1
    PGOHUM00000237280


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHCHD1 (see all 76)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs40823391,2
    C,F,H--75539812(+) CAACAT/CGAATC 1 -- us2k126Minor allele frequency- C:0.13NS EA NA WA 2438
    rs1928277541,2
    --75539913(+) GGAGTA/GTGGAG 1 -- us2k10--------
    rs1156443991,2
    C,F--75539931(+) GCAAGG/TCTGCT 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1848724041,2
    --75539948(+) ATTACA/TGCAAG 1 -- us2k10--------
    rs1478370441,2
    --75540164(+) CAAGAC/GTAGTC 1 -- us2k10--------
    rs790560761,2
    F--75540172(+) GTCTGC/TGCAAC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1414321591,2
    C--75540173(+) TCTGCA/GCAACA 1 -- us2k10--------
    rs583909341,2
    C,F--75540221(+) CAGCCG/AGGTTT 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1901656011,2
    --75540351(+) GACCCC/GAAATC 1 -- us2k10--------
    rs2014440191,2
    C--75540399(+) ACAAG-/TATT  
            
    TATTG
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHCHD1 (75541805 - 75543410 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CHCHD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv825468CNV Gain20364138
    nsv831912CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHCHD1
    DNA2.0 Custom Variant and Variant Library Synthesis for CHCHD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608842    OMIM disorders: --


    Find genes that share disorders with CHCHD1           About GenesLikeMe

    Genetic Association Database (GAD): CHCHD1
    Human Genome Epidemiology (HuGE) Navigator: CHCHD1 (2 documents)

    Export disorders for CHCHD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHCHD1 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with CHCHD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C2360, a nuclear protein expressed in human proliferative cytotrophoblasts, is a representative member of a novel protein family with a conserved coiled coil-helix-coiled coil-helix domain. (PubMed id 15177562)1, 2, 9 Westerman B.A.... Oudejans C.B.M. (Genomics 2004)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. (PubMed id 23908630)2 Koc E.C.... Koc H. (Front. Physiol. 2013)
    5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Sequence variants in four candidate genes (NIPSNAP1, GBAS, CHCHD1 and METT11D1) in patients with combined oxidative phosphorylation system deficiencies. (PubMed id 24137763)1 Smits P....van den Heuvel L.P. (J. Inherit. Metab. Dis. 2010)
    9. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 118487 HGNC: 23518 AceView: CHCHD1 Ensembl:ENSG00000172586 euGenes: HUgn118487
    ECgene: CHCHD1 H-InvDB: CHCHD1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHCHD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHCHD1 gene:
    Search GeneIP for patents involving CHCHD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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