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Aliases for CHCHD1 Gene

Aliases for CHCHD1 Gene

  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 1 2 3
  • 28S Ribosomal Protein S37, Mitochondrial 3 4
  • Nuclear Protein C2360 3 4
  • C10orf34 3 4
  • MRP-S37 3 4
  • Coiled-Coil-Helix-Coiled-Coil-Helix Domain-Containing Protein 1 3
  • Chromosome 10 Open Reading Frame 34 2
  • MRPS37 4
  • C2360 3

External Ids for CHCHD1 Gene

Previous HGNC Symbols for CHCHD1 Gene

  • C10orf34

Previous GeneCards Identifiers for CHCHD1 Gene

  • GC10P074887
  • GC10P075211
  • GC10P075541
  • GC10P069537

Summaries for CHCHD1 Gene

GeneCards Summary for CHCHD1 Gene

CHCHD1 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHCHD1 Gene

Genomics for CHCHD1 Gene

Regulatory Elements for CHCHD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHCHD1 Gene

73,782,047 bp from pter
73,783,652 bp from pter
1,606 bases
Plus strand

Genomic View for CHCHD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHCHD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHCHD1 Gene

Proteins for CHCHD1 Gene

  • Protein details for CHCHD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
    Protein Accession:
    Secondary Accessions:

    Protein attributes for CHCHD1 Gene

    118 amino acids
    Molecular mass:
    13475 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

neXtProt entry for CHCHD1 Gene

Proteomics data for CHCHD1 Gene at MOPED

Post-translational modifications for CHCHD1 Gene

  • Ubiquitination at Lys106
  • Modification sites at PhosphoSitePlus

Other Protein References for CHCHD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHCHD1 Gene

Domains for CHCHD1 Gene

Gene Families for CHCHD1 Gene

  • CHCHD :Coiled-coil-helix-coiled-coil-helix domain containing

Protein Domains for CHCHD1 Gene


Suggested Antigen Peptide Sequences for CHCHD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q96BP2
  • Contains 1 CHCH domain.
genes like me logo Genes that share domains with CHCHD1: view

Function for CHCHD1 Gene

Gene Ontology (GO) - Molecular Function for CHCHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with CHCHD1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHCHD1 Gene

Localization for CHCHD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHCHD1 Gene

Mitochondrion. Nucleus.

Subcellular locations from

Jensen Localization Image for CHCHD1 Gene COMPARTMENTS Subcellular localization image for CHCHD1 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3
extracellular 2

Gene Ontology (GO) - Cellular Components for CHCHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with CHCHD1: view

Pathways for CHCHD1 Gene

SuperPathways for CHCHD1 Gene

No Data Available

Interacting Proteins for CHCHD1 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: Q96BP2-CHCH1_HUMAN ENSP00000361923 for CHCHD1 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for CHCHD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with CHCHD1: view

No data available for Pathways by source for CHCHD1 Gene

Transcripts for CHCHD1 Gene

mRNA/cDNA for CHCHD1 Gene

(77) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHCHD1 Gene

Coiled-coil-helix-coiled-coil-helix domain containing 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHCHD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHCHD1 Gene

ExUns: 1 ^ 2 ^ 3

Relevant External Links for CHCHD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHCHD1 Gene

mRNA expression in normal human tissues for CHCHD1 Gene

Protein differential expression in normal tissues for CHCHD1 Gene

This gene is overexpressed in Breast (29.3) and Pancreas (26.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHCHD1 Gene

SOURCE GeneReport for Unigene cluster for CHCHD1 Gene Hs.181174

genes like me logo Genes that share expressions with CHCHD1: view

Expression partners for CHCHD1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHCHD1 Gene

Orthologs for CHCHD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHCHD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CHCHD1 35
  • 87.29 (n)
  • 85.59 (a)
  • 86 (a)
(Canis familiaris)
Mammalia CHCHD1 35
  • 85.03 (n)
  • 84.75 (a)
  • 85 (a)
(Mus musculus)
Mammalia Chchd1 35
  • 82.62 (n)
  • 83.76 (a)
Chchd1 16
Chchd1 36
  • 83 (a)
(Pan troglodytes)
Mammalia CHCHD1 35
  • 99.72 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Chchd1 35
  • 83.33 (n)
  • 83.9 (a)
(Monodelphis domestica)
Mammalia CHCHD1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia CHCHD1 36
  • 56 (a)
(Gallus gallus)
Aves CHCHD1 35
  • 58.08 (n)
  • 52.58 (a)
  • 44 (a)
(Anolis carolinensis)
Reptilia CHCHD1 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chchd1 35
  • 57.46 (n)
  • 53.85 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18472 35
(Danio rerio)
Actinopterygii chchd1 35
  • 53.05 (n)
  • 49.46 (a)
chchd1 36
  • 42 (a)
Species with no ortholog for CHCHD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHCHD1 Gene

Gene Tree for CHCHD1 (if available)
Gene Tree for CHCHD1 (if available)

Paralogs for CHCHD1 Gene Pseudogenes for CHCHD1 Gene

genes like me logo Genes that share paralogs with CHCHD1: view

No data available for Paralogs for CHCHD1 Gene

Variants for CHCHD1 Gene

Sequence variations from dbSNP and Humsavar for CHCHD1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1061969 -- 73,780,952(-) AGAAC(A/T)TTTGG upstream-variant-2KB
rs4082339 -- 73,780,054(+) CAACA(C/T)GAATC upstream-variant-2KB
rs4745722 -- 73,782,828(+) AATTG(C/T)TAGCT intron-variant
rs11000776 -- 73,783,461(+) CCCTA(A/G)GAGCA utr-variant-3-prime
rs11319379 -- 73,781,702(+) CGCCA(-/C)CCCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CHCHD1 Gene

Variant ID Type Subtype PubMed ID
nsv831912 CNV Gain 17160897
nsv825468 CNV Gain 20364138

Relevant External Links for CHCHD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHCHD1 Gene

Disorders for CHCHD1 Gene

Relevant External Links for CHCHD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for CHCHD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CHCHD1 Gene

Publications for CHCHD1 Gene

  1. C2360, a nuclear protein expressed in human proliferative cytotrophoblasts, is a representative member of a novel protein family with a conserved coiled coil-helix-coiled coil-helix domain. (PMID: 15177562) Westerman B.A. … Oudejans C.B.M. (Genomics 2004) 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3

Products for CHCHD1 Gene

Sources for CHCHD1 Gene

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