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Aliases for CHAMP1 Gene

Aliases for CHAMP1 Gene

  • Chromosome Alignment Maintaining Phosphoprotein 1 2 3
  • Zinc Finger Protein 828 2 3 4
  • C13orf8 3 4
  • ZNF828 3 4
  • CAMP 3 4
  • Chromosome Alignment-Maintaining Phosphoprotein 1 3
  • Chromosome Alignment-Maintaining Phosphoprotein 2
  • Chromosome 13 Open Reading Frame 8 2
  • KIAA1802 4
  • CHAMP 3

External Ids for CHAMP1 Gene

Previous HGNC Symbols for CHAMP1 Gene

  • C13orf8
  • ZNF828

Previous GeneCards Identifiers for CHAMP1 Gene

  • GC13P115080

Summaries for CHAMP1 Gene

GeneCards Summary for CHAMP1 Gene

CHAMP1 (Chromosome Alignment Maintaining Phosphoprotein 1) is a Protein Coding gene. Among its related pathways are Disease and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot for CHAMP1 Gene

  • Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.

Gene Wiki entry for CHAMP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAMP1 Gene

Genomics for CHAMP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CHAMP1 Gene

Start:
114,314,490 bp from pter
End:
114,327,328 bp from pter
Size:
12,839 bases
Orientation:
Plus strand

Genomic View for CHAMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAMP1 Gene

No data available for Regulatory Elements for CHAMP1 Gene

Proteins for CHAMP1 Gene

  • Protein details for CHAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JM3-CHAP1_HUMAN
    Recommended name:
    Chromosome alignment-maintaining phosphoprotein 1
    Protein Accession:
    Q96JM3
    Secondary Accessions:
    • B3KU06
    • Q6P181
    • Q8NC88
    • Q9BST0

    Protein attributes for CHAMP1 Gene

    Size:
    812 amino acids
    Molecular mass:
    89099 Da
    Quaternary structure:
    • Interacts with MAD2L2. Interacts with POGZ, CBX1, CBX3 and CBX5.
    SequenceCaution:
    • Sequence=BAB47431.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11273.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for CHAMP1 Gene

Proteomics data for CHAMP1 Gene at MOPED

Post-translational modifications for CHAMP1 Gene

  • Phosphorylated by CDK1. Mitotic phosphorylation is required for the attachment of spindle microtubules to the kinetochore.
  • Ubiquitination at Lys66
  • Modification sites at PhosphoSitePlus

Other Protein References for CHAMP1 Gene

No data available for DME Specific Peptides for CHAMP1 Gene

Domains for CHAMP1 Gene

Gene Families for CHAMP1 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for CHAMP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JM3

UniProtKB/Swiss-Prot:

CHAP1_HUMAN :
  • Q96JM3
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with CHAMP1: view

No data available for Suggested Antigen Peptide Sequences for CHAMP1 Gene

Function for CHAMP1 Gene

Molecular function for CHAMP1 Gene

UniProtKB/Swiss-Prot Function: Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore.

Gene Ontology (GO) - Molecular Function for CHAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 20850016
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CHAMP1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHAMP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHAMP1 Gene

Localization for CHAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHAMP1 Gene

Nucleus. Chromosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.

Gene Ontology (GO) - Cellular Components for CHAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 condensed chromosome kinetochore IDA 21063390
GO:0000793 condensed chromosome IDA 21063390
GO:0005634 nucleus IDA 21063390
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CHAMP1: view

No data available for Subcellular locations from COMPARTMENTS for CHAMP1 Gene

Pathways for CHAMP1 Gene

genes like me logo Genes that share pathways with CHAMP1: view

Pathways by source for CHAMP1 Gene

2 BioSystems pathways for CHAMP1 Gene
1 Reactome pathway for CHAMP1 Gene
2 KEGG pathways for CHAMP1 Gene

Interacting Proteins for CHAMP1 Gene

Gene Ontology (GO) - Biological Process for CHAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031134 sister chromatid biorientation IMP 21063390
GO:0034501 protein localization to kinetochore IMP 21063390
GO:0035372 protein localization to microtubule IMP 21063390
GO:0051315 attachment of mitotic spindle microtubules to kinetochore IMP 21063390
genes like me logo Genes that share ontologies with CHAMP1: view

Transcripts for CHAMP1 Gene

Unigene Clusters for CHAMP1 Gene

Chromosome alignment maintaining phosphoprotein 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CHAMP1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHAMP1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for CHAMP1 Gene

GeneLoc Exon Structure for
CHAMP1
ECgene alternative splicing isoforms for
CHAMP1

Expression for CHAMP1 Gene

mRNA expression in normal human tissues for CHAMP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CHAMP1 Gene

SOURCE GeneReport for Unigene cluster for CHAMP1 Gene Hs.7542

genes like me logo Genes that share expressions with CHAMP1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHAMP1 Gene

Orthologs for CHAMP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CHAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF828 35
  • 99.67 (n)
  • 99.63 (a)
ZNF828 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHAMP1 35
  • 89.51 (n)
  • 88.64 (a)
CHAMP1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHAMP1 35
  • 91.07 (n)
  • 91.98 (a)
CHAMP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Champ1 35
  • 78.86 (n)
  • 76.32 (a)
Champ1 36
  • 77 (a)
OneToOne
Zfp828 16
oppossum
(Monodelphis domestica)
Mammalia CHAMP1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHAMP1 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Champ1 35
  • 79.85 (n)
  • 77.85 (a)
chicken
(Gallus gallus)
Aves CHAMP1 35
  • 63.75 (n)
  • 57.96 (a)
CHAMP1 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHAMP1 36
  • 49 (a)
OneToOne
Species with no ortholog for CHAMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CHAMP1 Gene

ENSEMBL:
Gene Tree for CHAMP1 (if available)
TreeFam:
Gene Tree for CHAMP1 (if available)

Paralogs for CHAMP1 Gene

No data available for Paralogs for CHAMP1 Gene

Variants for CHAMP1 Gene

Sequence variations from dbSNP and Humsavar for CHAMP1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs2149431 -- 114,312,775(+) aaaaa(A/G)gaaaa upstream-variant-2KB
rs2402950 -- 114,312,771(+) aaaaa(A/G)aaaag upstream-variant-2KB
rs3764522 - 114,325,544(-) GAATA(C/G)AGCAG reference, missense
rs3813131 -- 114,324,544(+) TTCCC(A/G)GAAAC synonymous-codon, reference
rs3813132 -- 114,324,661(+) CGGAC(C/T)ACCTC synonymous-codon, reference

Relevant External Links for CHAMP1 Gene

HapMap Linkage Disequilibrium report
CHAMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CHAMP1 Gene

Disorders for CHAMP1 Gene

No disorders were found for CHAMP1 Gene.

No data available for UniProtKB/Swiss-Prot for CHAMP1 Gene

Publications for CHAMP1 Gene

  1. CAMP (C13orf8, ZNF828) is a novel regulator of kinetochore- microtubule attachment. (PMID: 21063390) Itoh G. … Tanaka K. (EMBO J. 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4

Products for CHAMP1 Gene

Sources for CHAMP1 Gene

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