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CHAF1B Gene

protein-coding   GIFtS: 59
GCID: GC21P037757

Chromatin Assembly Factor 1, Subunit B (P60)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Chromatin Assembly Factor 1, Subunit B (P60)1 2     CAF-I 60 KDa Subunit2 3
M-Phase Phosphoprotein 71 2 3     CAF-I P602 3
CAF1A2 3 5     Chromatin Assembly Factor I1
Human Chromatin Assembly Factor-I P60 Subunit2 11     P60 Subunit1
Chromatin Assembly Factor I P60 Subunit2 3     CAF-12
CAF1P602 3     CAF-IP602
MPHOSPH72 3     CAF12
MPP72 3     Chromatin Assembly Factor 1 Subunit B2
CAF-1 Subunit B2 3     

External Ids:    HGNC: 19111   Entrez Gene: 82082   Ensembl: ENSG000001592597   OMIM: 6012455   UniProtKB: Q131123   

Export aliases for CHAF1B gene to outside databases

Previous GC identifers: GC21P034335 GC21P034418 GC21P036678 GC21P036679 GC21P023233


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHAF1B Gene:
Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA.
CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to
the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially
phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during
mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may
also be involved in DNA repair. (provided by RefSeq, Jul 2008)

GeneCards Summary for CHAF1B Gene:
CHAF1B (chromatin assembly factor 1, subunit B (p60)) is a protein-coding gene. GO annotations related to this gene include chromatin binding and histone binding.

UniProtKB/Swiss-Prot: CAF1B_HUMAN, Q13112
Function: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles
histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process,
bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin
precursor subsequent to DNA replication to complete the histone octamer

Gene Wiki entry for CHAF1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHAF1B gene promoter:
         HFH-3   Nkx2-2   STAT5A   Tal-1beta   LCR-F1   E47   FOXI1   FAC1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHAF1B promoter sequence

   Search Chromatin IP Primers for CHAF1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHAF1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.13   Ensembl cytogenetic band:  21q22.12   HGNC cytogenetic band: 21q22.2
Nature(405: 311-319) cytogenetic band:   21q22.13
CHAF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHAF1B gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P037757:   GeneLoc Nature:405,311-319
Start:
37,757,676 bp from pter       23,334,828 bp from centromere
End:
37,791,313 bp from pter 23,365,571 bp from centromere
Size:
33,638 bases 30,744 bases
Orientation:
plus strand plus strand

Whole chromosome sequencing:
cDNA sequence: U20980
genomic clones: KB5G11


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAF1B_HUMAN, Q13112 (See protein sequence)
Recommended Name: Chromatin assembly factor 1 subunit B  
Size: 559 amino acids; 61493 Da
Subunit: Subunit of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B.
Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. In G2 and S phase also monomeric
CHAF1B is detected
Developmental stage: Active complex is found in G1, S and G2 phases
Secondary accessions: Q99548

Explore the universe of human proteins at neXtProt for CHAF1B: NX_Q13112

Explore proteomics data for CHAF1B at MOPED

Post-translational modifications: 

  • Differentially phosphorylated during cell cycle. During mitosis the p60 subunit of inactive CAF-1 is
    hyperphosphorylated and displaced into the cytosol. Progressivly dephosphorylated from G1 to S and G2 phase.
    Phosphorylated p60 is recruited to chromatin undergoing DNA repair after UV irradiation in G1, S or G2 phases1
  • Ubiquitination2 at Lys211, Lys234, Lys385, Lys494
  • Modification sites at PhosphoSitePlus

  • See CHAF1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005432.1  
    ENSEMBL proteins: 
     ENSP00000315700  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR001632 Gprotein_B
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q13112

    ProtoNet protein and cluster: Q13112

    2 Blocks protein domains:
    IPB001632 Beta G-protein (transducin) signature
    IPB001680 G-protein beta WD-40 repeat signature


    UniProtKB/Swiss-Prot: CAF1B_HUMAN, Q13112
    Similarity: Belongs to the WD repeat HIR1 family
    Similarity: Contains 7 WD repeats


    Find genes that share domains with CHAF1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAF1B_HUMAN, Q13112
    Function: Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles
    histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process,
    bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin
    precursor subsequent to DNA replication to complete the histone octamer

         Genatlas biochemistry entry for CHAF1B:
    chromatin assembly factor 1 subunit B,p60,histone chaperone assembling nucleosomes,on replicating DNA

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding TAS7600578
    GO:0005515protein binding ----
    GO:0042393histone binding NAS7600578
    GO:0051082unfolded protein binding TAS7600578
         
    Find genes that share ontologies with CHAF1B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CHAF1B:
     Decreased G3BP1 protein expres  Wnt reporter upregulated 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CHAF1B
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    2 qRT-PCR Assays for microRNAs that regulate CHAF1B:
    hsa-miR-516b hsa-miR-34b
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAF1B_HUMAN, Q13112: Nucleus. Cytoplasm. Note=DNA replication foci. Cytoplasmic in M phase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS9614144
    GO:0005654colocalizes with nucleoplasm IDA16780588
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS9614144
    GO:0005829colocalizes with cytosol IDA16780588

    Find genes that share ontologies with CHAF1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHAF1B
    Interactions:

        GeneGlobe Interaction Network for CHAF1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHAF1B (Q131122, 3 ENSP000003157004) via UniProtKB, MINT, STRING, and/or I2D (see all 142)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4BP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4CP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4DP628052, 3MINT-7220359 I2D: score=2 
    HIST1H4EP628052, 3MINT-7220359 I2D: score=2 
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    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--
    GO:0006335DNA replication-dependent nucleosome assembly TAS7600578
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with CHAF1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CHAF1B (CAF1B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHAF1B gene: 
    NM_005441.2  

    Unigene Cluster for CHAF1B:

    Chromatin assembly factor 1, subunit B (p60)
    Hs.75238  [show with all ESTs]
    Unigene Representative Sequence: NM_005441
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314103(uc002yvj.3) ENST00000480486 ENST00000481458
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate CHAF1B:
    hsa-miR-516b hsa-miR-34b
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      QuantiTect SYBR Green Assays in human, mouse, rat CHAF1B
      QuantiFast Probe-based Assays in human, mouse, rat CHAF1B

    Additional mRNA sequence: 

    AJ001856.1 AK092781.1 AK313152.1 BC001143.1 BC021218.2 U20980.1 X98262.1 

    6 DOTS entries:

    DT.114283  DT.99928033  DT.114282  DT.101957749  DT.95103371  DT.91760581 

    Selected AceView cDNA sequences (see all 103):

    BE792667 BP365327 CA489373 CR597529 BI256357 AL561489 AL554979 BM550351 
    BP353233 BM550731 BG390662 BX436477 NM_005441 BC021218 R39347 AK092781 
    BM477513 BF509884 BM808292 BX090123 CA454762 BE266830 U20980 T16685 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHAF1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHAF1B Expression
    About this image


    CHAF1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CHAF1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHAF1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75238
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CHAF1B gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chaf1b1 , 5 chromatin assembly factor 1, subunit B (p60)1, 5 81.84(n)1
    84.41(a)1
      16 (54.96 cM)5
    1107491  NM_028083.41  NP_082359.11 
     938839015 
    chicken
    (Gallus gallus)
    Aves CHAF1B1 chromatin assembly factor 1, subunit B (p60) 74.07(n)
    77.24(a)
      418514  NM_001008677.2  NP_001008677.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHAF1B6
    chromatin assembly factor 1, subunit B (p60)
    71(a)
    1 ↔ 1
    3(141421629-141435924)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77812 Xenopus laevis transcribed sequence with moderate similarity more 77.81(n)    BJ615996.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.35222 Danio rerio mRNA similar to chromatin assembly factor more 76.65(n)    BC045906.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Caf1-1051 , 3 chromatin assembly/disassembly
    histone-specific more3
    Caf1-1051
    39(a)3
    55.18(n)1
    49.21(a)1
      47A93
    361071  NM_136745.51  NP_610589.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71G12B.1b3   -- 33(a)
    (best of 2)
      I(1823455-1825906)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CAC2(YML102W)4 Component of the chromatin assembly complex (with Rlf2p more   --   13(68294-69700) 854869  NP_013605.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FAS21 FAS2 53.13(n)
    45.18(a)
      836584  NM_203262.2  NP_974991.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01082001 Os08g0108200 53.13(n)
    44.75(a)
      4344464  NM_001067339.1  NP_001060804.1 


    ENSEMBL Gene Tree for CHAF1B (if available)
    TreeFam Gene Tree for CHAF1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHAF1B gene

    Find genes that share paralogs with CHAF1B           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CHAF1B
    PGOHUM00000243727


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHAF1B (see all 738)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807009141,2
    --37755743(+) AATGCC/TTTGAG 1 -- us2k10--------
    rs9685991,2
    H--37755760(-) GCTTCG/AAAAAA 1 -- us2k14Minor allele frequency- A:0.00NS EA 416
    rs1381493801,2
    C--37755775(+) TTAAG-/AGTT  
            
    AGTCC
    1 -- us2k10--------
    rs1864680721,2
    --37755801(+) TTTCAC/TTATTA 1 -- us2k10--------
    rs1154131331,2
    C,F--37755919(+) AGTTAG/CAATTG 1 -- us2k11Minor allele frequency- C:0.09WA 118
    rs2186271,2
    C,A,H--37756035(-) CGGGAG/AGCGGG 1 -- us2k12Minor allele frequency- A:0.00NA 4
    rs1897170731,2
    --37756060(+) TCTTGC/TCTCAG 1 -- us2k10--------
    rs1502070941,2
    C--37756191(+) TCCGCC/TCACCT 1 -- us2k10--------
    rs713266821,2
    C--37756299(+) TTTTTT/-GAGAA 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1816561661,2
    --37756580(+) GAGACA/GCGAAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CHAF1B (37757676 - 37791313 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CHAF1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33578CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHAF1B
    DNA2.0 Custom Variant and Variant Library Synthesis for CHAF1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601245    OMIM disorders: --


    Find genes that share disorders with CHAF1B           About GenesLikeMe


    Export disorders for CHAF1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHAF1B gene, integrated from 10 sources (see all 77):
    (articles sorted by number of sources associating them with CHAF1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication. (PubMed id 7600578)1, 2, 3 Kaufman P.D.... Stillman B. (Cell 1995)
    2. Nucleosome assembly activity and intracellular localization of human CAF-1 changes during the cell division cycle. (PubMed id 9614144)1, 2, 9 Marheineke K. and Krude T. (J. Biol. Chem. 1998)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair. (PubMed id 10893180)1, 2 Ridgway P. and Almouzni G. (J. Cell Sci. 2000)
    6. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    7. Recruitment of phosphorylated chromatin assembly factor 1 to chromatin after UV irradiation of human cells. (PubMed id 9813080)1, 2 Martini E.... Almouzni G. (J. Cell Biol. 1998)
    8. The gene encoding the p60 subunit of chromatin assembly factor I (CAF1P60) maps to human chromosome 21q22.2, a region associated with some of the major features of Down syndrome. (PubMed id 8792829)1, 3 Katsanis N. and Fisher E.M. (Hum. Genet. 1996)
    9. Identification of novel M phase phosphoproteins by expression cloning. (PubMed id 8885239)1, 2 Matsumoto-Taniura N....Westendorf J.M. (Mol. Biol. Cell 1996)
    10. Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. (PubMed id 11897662)1, 9 Mello J.A....Almouzni G. (EMBO Rep. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8208 HGNC: 1911 AceView: CHAF1B Ensembl:ENSG00000159259 euGenes: HUgn8208
    ECgene: CHAF1B H-InvDB: CHAF1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHAF1B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHAF1B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHAF1B gene:
    Search GeneIP for patents involving CHAF1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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