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Aliases for CHAF1B Gene

Aliases for CHAF1B Gene

  • Chromatin Assembly Factor 1 Subunit B 2 3 5
  • M-Phase Phosphoprotein 7 2 3 4
  • Human Chromatin Assembly Factor-I P60 Subunit 2 3
  • Chromatin Assembly Factor 1, Subunit B (P60) 2 3
  • Chromatin Assembly Factor I P60 Subunit 3 4
  • CAF-I 60 KDa Subunit 3 4
  • CAF-1 Subunit B 3 4
  • CAF-I P60 3 4
  • MPHOSPH7 3 4
  • CAF1P60 3 4
  • CAF1A 3 4
  • MPP7 3 4
  • Chromatin Assembly Factor I 2
  • P60 Subunit 2
  • CAF-IP60 3
  • CAF-1 3
  • CAF1 3

External Ids for CHAF1B Gene

Previous GeneCards Identifiers for CHAF1B Gene

  • GC21P034335
  • GC21P034418
  • GC21P036678
  • GC21P036679
  • GC21P037757
  • GC21P023233

Summaries for CHAF1B Gene

Entrez Gene Summary for CHAF1B Gene

  • Chromatin assembly factor I (CAF-I) is required for the assembly of histone octamers onto newly-replicated DNA. CAF-I is composed of three protein subunits, p50, p60, and p150. The protein encoded by this gene corresponds to the p60 subunit and is required for chromatin assembly after replication. The encoded protein is differentially phosphorylated in a cell cycle-dependent manner. In addition, it is normally found in the nucleus except during mitosis, when it is released into the cytoplasm. This protein is a member of the WD-repeat HIR1 family and may also be involved in DNA repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHAF1B Gene

CHAF1B (Chromatin Assembly Factor 1 Subunit B) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CHAF1B Gene

  • Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.

Gene Wiki entry for CHAF1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAF1B Gene

Genomics for CHAF1B Gene

Regulatory Elements for CHAF1B Gene

Genomic Location for CHAF1B Gene

Chromosome:
21
Start:
36,377,057 bp from pter
End:
36,419,015 bp from pter
Size:
41,959 bases
Orientation:
Plus strand

Genomic View for CHAF1B Gene

Genes around CHAF1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHAF1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHAF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAF1B Gene

Proteins for CHAF1B Gene

  • Protein details for CHAF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13112-CAF1B_HUMAN
    Recommended name:
    Chromatin assembly factor 1 subunit B
    Protein Accession:
    Q13112
    Secondary Accessions:
    • Q99548

    Protein attributes for CHAF1B Gene

    Size:
    559 amino acids
    Molecular mass:
    61493 Da
    Quaternary structure:
    • Subunit of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. In G2 and S phase also monomeric CHAF1B is detected.

neXtProt entry for CHAF1B Gene

Proteomics data for CHAF1B Gene at MOPED

Post-translational modifications for CHAF1B Gene

  • Differentially phosphorylated during cell cycle. During mitosis the p60 subunit of inactive CAF-1 is hyperphosphorylated and displaced into the cytosol. Progressivly dephosphorylated from G1 to S and G2 phase. Phosphorylated p60 is recruited to chromatin undergoing DNA repair after UV irradiation in G1, S or G2 phases.
  • Ubiquitination at Lys 211, Lys 234, Lys 385, and Lys 494
  • Modification sites at PhosphoSitePlus

Other Protein References for CHAF1B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CHAF1B Gene

Domains & Families for CHAF1B Gene

Gene Families for CHAF1B Gene

Suggested Antigen Peptide Sequences for CHAF1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13112

UniProtKB/Swiss-Prot:

CAF1B_HUMAN :
  • Belongs to the WD repeat HIR1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat HIR1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with CHAF1B: view

Function for CHAF1B Gene

Molecular function for CHAF1B Gene

GENATLAS Biochemistry:
chromatin assembly factor 1 subunit B,p60,histone chaperone assembling nucleosomes,on replicating DNA
UniProtKB/Swiss-Prot Function:
Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.
genes like me logo Genes that share phenotypes with CHAF1B: view

Animal Model Products

miRNA for CHAF1B Gene

miRTarBase miRNAs that target CHAF1B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CHAF1B Gene

Localization for CHAF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHAF1B Gene

Nucleus. Cytoplasm. Note=DNA replication foci. Cytoplasmic in M phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHAF1B Gene COMPARTMENTS Subcellular localization image for CHAF1B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for CHAF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 9614144
genes like me logo Genes that share ontologies with CHAF1B: view

Pathways & Interactions for CHAF1B Gene

SuperPathways for CHAF1B Gene

No Data Available

Gene Ontology (GO) - Biological Process for CHAF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with CHAF1B: view

No data available for Pathways by source and SIGNOR curated interactions for CHAF1B Gene

Drugs & Compounds for CHAF1B Gene

No Compound Related Data Available

Transcripts for CHAF1B Gene

Unigene Clusters for CHAF1B Gene

Chromatin assembly factor 1, subunit B (p60):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHAF1B Gene

No ASD Table

Relevant External Links for CHAF1B Gene

GeneLoc Exon Structure for
CHAF1B
ECgene alternative splicing isoforms for
CHAF1B

Expression for CHAF1B Gene

mRNA expression in normal human tissues for CHAF1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHAF1B Gene

This gene is overexpressed in Muscle - Skeletal (x6.6).

Protein differential expression in normal tissues from HIPED for CHAF1B Gene

This gene is overexpressed in Lung (31.2), Testis (18.5), and Ovary (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHAF1B Gene



SOURCE GeneReport for Unigene cluster for CHAF1B Gene Hs.75238

genes like me logo Genes that share expression patterns with CHAF1B: view

Protein tissue co-expression partners for CHAF1B Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CHAF1B Gene

Orthologs for CHAF1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHAF1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHAF1B 36
  • 100 (a)
OneToOne
CHAF1B 35
  • 99.52 (n)
  • 99.64 (a)
cow
(Bos Taurus)
Mammalia CHAF1B 36
  • 84 (a)
OneToOne
CHAF1B 35
  • 83.48 (n)
  • 86.4 (a)
dog
(Canis familiaris)
Mammalia CHAF1B 35
  • 86.96 (n)
  • 91.14 (a)
CHAF1B 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chaf1b 16
Chaf1b 36
  • 82 (a)
OneToOne
Chaf1b 35
  • 81.84 (n)
  • 84.41 (a)
oppossum
(Monodelphis domestica)
Mammalia CHAF1B 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHAF1B 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chaf1b 35
  • 82.02 (n)
  • 84.77 (a)
chicken
(Gallus gallus)
Aves CHAF1B 35
  • 74.07 (n)
  • 77.24 (a)
CHAF1B 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHAF1B 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7781 35
tropical clawed frog
(Silurana tropicalis)
Amphibia chaf1b 35
  • 66.98 (n)
  • 69.33 (a)
zebrafish
(Danio rerio)
Actinopterygii chaf1b 36
  • 56 (a)
OneToOne
chaf1b 35
  • 74.02 (n)
  • 77.94 (a)
Dr.3522 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007544 35
  • 51.16 (n)
  • 44.38 (a)
fruit fly
(Drosophila melanogaster)
Insecta Caf1-105 36
  • 31 (a)
OneToOne
Caf1-105 37
  • 39 (a)
Caf1-105 35
  • 55.18 (n)
  • 49.21 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.1a 37
  • 33 (a)
Y71G12B.1b 37
  • 33 (a)
chaf-2 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAC2 36
  • 34 (a)
OneToOne
CAC2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons FAS2 35
  • 53.13 (n)
  • 45.18 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.11475 35
rice
(Oryza sativa)
Liliopsida Os08g0108200 35
  • 53.13 (n)
  • 44.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
Species with no ortholog for CHAF1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHAF1B Gene

ENSEMBL:
Gene Tree for CHAF1B (if available)
TreeFam:
Gene Tree for CHAF1B (if available)

Paralogs for CHAF1B Gene

Pseudogenes.org Pseudogenes for CHAF1B Gene

genes like me logo Genes that share paralogs with CHAF1B: view

No data available for Paralogs for CHAF1B Gene

Variants for CHAF1B Gene

Sequence variations from dbSNP and Humsavar for CHAF1B Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs74900401 - 36,415,317(+) CCTTA(A/C/T)AGACG reference, missense, stop-gained
rs8596 -- 36,416,582(+) TTAAC(A/G)TAGTA utr-variant-3-prime
rs218623 -- 36,378,958(-) ATGGC(C/T)AATGT intron-variant
rs218624 -- 36,379,076(-) AGTTT(C/T)TGGGT intron-variant
rs218625 -- 36,381,472(-) TATTA(C/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHAF1B Gene

Variant ID Type Subtype PubMed ID
esv33578 CNV Loss 17666407

Variation tolerance for CHAF1B Gene

Residual Variation Intolerance Score: 22.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.87; 67.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHAF1B Gene

HapMap Linkage Disequilibrium report
CHAF1B
Human Gene Mutation Database (HGMD)
CHAF1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHAF1B Gene

Disorders for CHAF1B Gene

Relevant External Links for CHAF1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHAF1B

No disorders were found for CHAF1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHAF1B Gene

Publications for CHAF1B Gene

  1. The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication. (PMID: 7600578) Kaufman P.D. … Stillman B. (Cell 1995) 2 3 4 67
  2. New histone incorporation marks sites of UV repair in human cells. (PMID: 17081972) Polo S.E. … Almouzni G. (Cell 2006) 3 23
  3. Silencing of chromatin assembly factor 1 in human cells leads to cell death and loss of chromatin assembly during DNA synthesis. (PMID: 15024074) Nabatiyan A. … Krude T. (Mol. Cell. Biol. 2004) 3 23
  4. Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway. (PMID: 11897662) Mello J.A. … Almouzni G. (EMBO Rep. 2002) 3 23
  5. Requirement of Cyclin/Cdk2 and protein phosphatase 1 activity for chromatin assembly factor 1-dependent chromatin assembly during DNA synthesis. (PMID: 10938080) Keller C. … Krude T. (J. Biol. Chem. 2000) 3 23

Products for CHAF1B Gene

Sources for CHAF1B Gene

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